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Delphi-Driven Consensus Definition For Mesenchymal Stromal Cells And Clinical Reporting Guidelines For Mesenchymal Stromal Cell-Based Therapeutics, Laurent Renesme, Kelly D. Cobey, Manoj M. Lalu, Tania M. Bubela, Raghavan Chinnadurai, John De Vos, Rod Dunbar, Dean Fergusson, Daniel Freund, Jacques Galipeau

Office of the Provost

Background aims: Despite promising results in pre-clinical studies, mesenchymal stromal cells (MSCs) face significant challenges in clinical translation. A scoping review by our group highlighted two key issues contributing to this gap: (i) lack of a clear and consensus definition for MSCs and (ii) under-reporting of critical parameters in MSC clinical studies. To address these issues, we conducted a modified Delphi study to establish and implement a consensus definition for MSCs and develop reporting guidelines for MSC clinical studies.
Methods: A steering committee of 22 international experts, including stakeholders from different MSC research fields, participated in the three Delphi rounds. …

Environmental Monitoring Report: For Work To Be Performed: July 1, 2023 Through June 30, 2024, Tennessee. Department Of Environment And Conservation

Environmental Monitoring Reports

This FY2024 EMR presents results for independent projects, originally defined in TDEC’s FY2024 Environmental Monitoring Plan (EMP) and subsequently completed over the course of FY2024 period of performance.

Potential Effects Of Statistical Complexity Measure In Improving The Fault Diagnosis Performance Under Speed Fluctuations, S. Sowmya, M. Saimurugan, N. Kannan, Immanuel A. Edinbarough

Informatics and Engineering Systems Faculty Publications

Many research studies are performed in extracting non-stationary signal properties such as instantaneous frequency (IF) and envelope to diagnose machinery faults under time-varying speed conditions. But accurate IF extraction is difficult from such complex fluctuating signals to identify the faults efficiently. Therefore, this paper proposes the Statistical Complexity Measure (SCM) as a feature that evaluates the randomness and complexity without any additional requirement, providing an outstanding result in multi-component fault detection under speed fluctuations. Primarily, the influence of SCM is proved by ranking the features with the help of the Random Forest (RF) algorithm. The fault classification of individual signal …

Environmental Monitoring Plan: For Work To Be Performed: July 1, 2025, Through June 30, 2026, Tennessee. Department Of Environment And Conservation.

Environmental Monitoring Plans

The Tennessee Department of Enviornment and Conservation, Division of Remediation, Oak Ridge (TDEC DoR-OR), provides the annual Fiscal Year 2026 EMP for the period of July 1, 2025, through June 30, 2026. This report is submitted as a comprehensive plan for TDEC DoR-OR monitoring and assessment activities across the Oak Ridge Reservation, Oak Ridge, Tennessee, (ORR) in accordance with terms of both the Environmental Surveillance and Oversight Agreement (ESOA), as well as in support of activities being conducted under the Federal Facilities Agreement (FFA).

Inhibition Of Lysine Deacetylase Activity Impacts Formation Of The Vitamin D Receptor Activation Complex, Shannon Dwyer

Theses and Dissertations

The vitamin D endocrine system is responsible for the regulation of many biological processes including bone metabolism, calcium homeostasis, cell proliferation and cell differentiation. Alterations to the vitamin D signaling pathway are associated with several diseases including bone diseases, diabetes, cardiovascular diseases, autoimmune diseases, and cancer. Vitamin D precursors are chemically modified to become the biologically active hormone, calcitriol. Calcitriol binds to the vitamin D receptor (VDR), a member of the nuclear hormone receptor (NHR) superfamily. VDR forms a heterodimer with retinoid X receptor (RXR) and together they bind to promoters containing vitamin D response elements (VDREs) to activate transcription …

Consequences Of Oxidative Dna Damage: Base-Pair Dissociation, Singlet Oxygenation And Dna-Protein Crosslinking, May Myat Moe

Dissertations, Theses, and Capstone Projects

8-Oxo-2′-deoxyguanosine (OG) is a common DNA lesion resulting from oxidatively generated damage and pairs with complementary cytidine (C) in Watson Crick base-pairing within duplex DNA. The WC-OG·C lesion, if not recognized or repaired, not only leads to G⋅C→T⋅A transversion mutations (through Hoogsteen (HG) base pairing of OG⋅A), but also renders the base pair being more vlunerable to ionizing radiation and singlet oxygen (1O2) damage. Leveraging on our previous accomplishments on the study of gas-phase reactions of 1O2 with 2′-deoxyguanosine radical cations, my research thesis expanded to the investigation of reaction dynamics of 9-methyl-8-oxoguanine (9MOG) radical cations. The experiments of following …

The Role Of Secondary And Tertiary Structure In The Cap-Independent Translation Of Fgf-9 And Hif-1-Alpha, Amanda Michelle Whittaker

Dissertations, Theses, and Capstone Projects

Under normoxic conditions, eukaryotes initiate translation of RNA through eIF4E recognition of the 5’ cap. However, under cellular stress, eukaryotic translation must be initiated through a 4E-independent, or “cap-independent” mechanism, involving eukaryotic initiation factor 4G (eIF4G) binding directly to the 5’ untranslated regions (5’ UTR) of the RNA. eIF4G binding then recruits the ribosome to the transcript. While this mechanism is useful for translation of apoptotic transcripts and transcripts involved in cell survival, cap-independent translation is also utilized by oncogenic RNA for tumorigenesis. Previous work by our lab and others has categorized this recruitment and initiation mechanism as either internal-ribosome-entry-site …

When College Is Not Working Out: Obstacles To Community College Completion, Elisabeth Lackner

Dissertations, Theses, and Capstone Projects

My dissertation investigates what contributes to low community college completion rates, what college interventions may be working to support students, what are the experiences of the students, and how did the COVID-19 pandemic impact these dynamics. I am guided by the assumption that multi-dimensional inequalities including low level of social capital constitute a cumulative disadvantage for many students to be able to persist and to graduate. The dissertation includes quantitative and qualitative data types measuring inequalities outside and inside of college with two large student record data sets from one minority-serving open-access public community college and data from a student …

Constructing A Parameterized Stimuli Space Suitable To Induce Controlled Changes In Human And Machine Perceptual Systems, Andrew Frankel

Dissertations, Theses, and Capstone Projects

Traditional computer vision applications focus on objective tasks, such as object detection, classification, or segmentation. Much of human experience is inherently subjective, such as our personal response to artwork. Individualized experiences are challenging to replicate in a controlled laboratory environment, as those experiences depend on the unique history and internal models of the observer. This work presents a technique to construct a 2-dimensional parameterized stimuli space suitable to induce controlled changes in the perceptual systems of both human and machine observers. Our contributions are threefold:

1. Using a balanced dataset of 8,800 fine art images spanning 11 art movements and 88 …

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Studies On The Synthesis, Function, And Properties Of Troponoids, John-Charles A. Baucom

Dissertations, Theses, and Capstone Projects

Troponoids are a unique class of non-benzenoid aromatic compounds with a wide range of demonstrated applications in pharmaceuticals and molecular sensing. The cycloheptatrienone scaffold possesses a noteworthy degree of tunability as a function of ring oxygenation. This manuscript describes our efforts toward a better understanding of the physical consequences of the scaffold to better utilize the motif. Chapter the first discusses our efforts at elucidating the mechanism of troponoid inhibition of the Hepatitis B virus reverse transcriptase RNAse H enzymatic domain. Using homology modeling in conjunction with traditional in vitro assays we were able to establish the likely mechanism of …

The Effects Of Irrelevant Parameters In Language Acquisition, Yukun Zhang

Dissertations, Theses, and Capstone Projects

This paper investigates the effects of sententially irrelevant syntactic information on language acquisition models and introduces a new variant of the variational learner (VL) called the early decision variational learner (EDVL). EDVL accelerates convergence by locking in parameter values once they reach a threshold, in contrast to VL’s continued adjustments until all parameter values reach threshold. Both learners are grounded in the generative approach to language acquisition. We examine both learners' responses when they only update their parameter values when the input contain the relevant information to determin the parameter value such as prepositions, wh-words, and auxiliary verbs. Chapter 1 …

Tracing The Sources Of Nitrogen In Submarine Groundwater Discharge And Primary Producers In The Great South Bay Estuary, Nia H. Rene

Dissertations, Theses, and Capstone Projects

The primary aim of this research was to elucidate the impact of submarine groundwater discharge (SGD) and septic effluent on coastal primary producers in the Great South Bay (GSB). The study focused on three main objectives: assessing the impact of precipitation patterns on SGD, tracing nitrogen sources into the GSB, and determining the impact of these nitrogen sources on coastal primary producers. The research revealed that current precipitation patterns significantly influence SGD across different seasons, highlighting the seasonal variability in groundwater discharge and its implications for nutrient loading in coastal waters. A suite of tracers was employed to identify and …

Characterizing The Nutrition-Gut Microbiome-Host Physiology Axis To Examine Flexibility In A Fruit-Specialist Primate, Nina Beeby

Dissertations, Theses, and Capstone Projects

Nutrition and, increasingly, microbiota are recognized in shaping all aspects of animal behavioral ecology and physiology. Since diet and nutrition shape not only animal physiology but also gut microbiota, and these microbiota serve as suppliers of and competitors to host nutrition, this raises questions of how these complex nutritional and microbial environments synergistically affect animal physiology. Examining this nutrition-gut microbiome-host physiology axis has immense potential to unveil how these intricate relationships contribute to animals’ responses to environmental change at multiple scales. Most of what we know about primate responses to environmental change is based upon studies examining one or few …

Advancing Structural And Textual Guidance In Medical Image Segmentation: A Journey From Fully Supervised To Weakly Supervised Learning, Jiaqi Yang

Dissertations, Theses, and Capstone Projects

Accurate segmentation of medical images is essential for clinical diagnosis, enabling precise measurement, monitoring, and analysis of anatomical structures. While advanced models have achieved impressive per-pixel performance under fully supervised settings, ensuring fine-scale structural completeness remains a challenge, particularly for complex biomedical structures where coherence and integrity are critical. Fully supervised methods also face inherent limitations due to their reliance on extensive pixel-level annotations. These annotations are labor-intensive, costly, and often suffer from low inter-expert agreement, especially in cases like OCT images where small lesions and unclear boundaries make precise labeling difficult. This underscores the challenge of acquiring large, high-quality …

Taming Biological Complexity Through The Use Of Symmetries, Luis A. Álvarez-García

Dissertations, Theses, and Capstone Projects

The study of biological systems is, inherently, the study of very complex systems. This is essentially due to the fact that they are made up of numerous, often very complicated, interactions between an extensive number of components. Often necessitating an abundance of quantitative parameters and details for a precise description. The human brain for ex- ample, consisting of ∼ 80 billion neurons with ∼ 800 to 100 trillion connections between them, each of them depending on a large set of parameters. Even simpler examples such as bacterial organisms, such as E. coli and B. subtilis, which we focus on …

Development Of Soil Survey Methods For Urban Areas, Kohinoor Begum

Dissertations, Theses, and Capstone Projects

Urban soils are the foundation of urban ecosystems and play a vital role in long-term urban sustainability and resiliency. Accurate soil surveys of urban areas should be done at higher resolution since extensive human activities often result in urban soil being highly disturbed and spatially variable. Besides heterogeneity, one of the unique and challenging aspects of urban soil is the nature and properties of its organic carbon with a significant percentage of black carbon (a particulate product of incomplete combustion), which is less biologically active. Thus, in order to determine the ability of a soil to support biological activity and …

Novel Alchemical Methodologies For Modeling Molecular Binding, Solmaz Azimi

Dissertations, Theses, and Capstone Projects

Molecular recognition is fundamental to all biological and biochemical processes. Understanding the interactions between molecules is the foundation for drug discovery and development, for understanding biological processes, and for the design of biosensors and nanomaterials. There is tremendous interest in the development of computer models to predict molecular association equilibria. In structure-based drug discovery enterprises, predicting the strength and selectivity of a small molecule to a biological target can advance target identification, aid ligand design, and accelerate high-throughput screening of drug compounds. This work focuses on free energy models, a class of computational methodologies grounded on the fundamental physical and …

Quantified Lives: Data, Bias, And The Cost Of Categorization, Colin F. Geraghty

Dissertations, Theses, and Capstone Projects

This project critically examines how statistical methods and data visualization have historically been used to categorize, rank, and control human populations. By exploring the works of key figures like Francis Galton, Karl Pearson, and R.A. Fisher, it traces the evolution of categorization frameworks from their eugenic roots to modern applications in artificial intelligence and global metrics like the World Happiness Report. Through interactive visualizations and historical analysis, the project invites users to question the legitimacy of these frameworks and reflect on their impact on society. At its core, this work emphasizes the need to move beyond rigid classification systems, challenging …

Chatgpt Didn’T Write This: Evaluating The Impact Of Llms With A Case Study In Grading Cuny Language Immersion Program Student Essays, Benjamin Inbar

Dissertations, Theses, and Capstone Projects

This study evaluates the capabilities and limitations of large language models (LLMs), specifically OpenAI’s ChatGPT-4o, in grading essays from students in the City University of New York’s Language Immersion Program. The program serves English language learners with diverse linguistic and demographic backgrounds, offering intensive language instruction to prepare students for academic success in college. Using a dataset of 30 pre- and post-program essays scored by program instructors and ChatGPT-4o under three paradigms, this research explores the alignment between human and AI-generated scores across five rubric-based competency areas. Findings reveal that ChatGPT-4o aligns moderately with human grading, with the strongest agreement …

Characterizing Malaria Infections In Caribbean Lizards: Parasite Niche Expansion & Host Response, Sarah J. Pangburn

Dissertations, Theses, and Capstone Projects

Malaria is historically one of the most severe parasitic human diseases and is still responsible for over half a million deaths annually. Plasmodium species, the causative agents of malaria, are often characterized by two hallmark features of their asexual stages: the invasion of vertebrate red blood cells and the presence of hemozoin pigment as a byproduct of host hemoglobin digestion. Despite their evolutionary relatedness to mammalian Plasmodium, wildlife malaria parasites are understudied, leaving their vast genetic diversity to be explored. Lizard-infective malaria parasites, for example, include over 100 species of Plasmodium and present a diverse array of phenotypes, some …

Mad At The System: The Mental Health Act Uk: Power And Control Of Racialized Women, Maithreyi Rajeshkumar

Dissertations, Theses, and Capstone Projects

Whilst experiences of madness are multiple, fluid and multi-dimensional across spiritual and collective dimensions globally, the categorization and regulation of ‘madness’ have direct foundations in European colonial-capitalist-patriarchal frameworks, policies and systems. This work focuses on the institutions and structures of power, turning UK legislation and those who are trying to reform or change it, into objects of study. A particular piece of United Kingdom legislation is the primary case study for this work – the Mental Health Act 1983 which covers the rights, assessment and treatment of people diagnosed with a ‘mental disorder’. Women, who are detained under this Act …

Defending Children’S Data Privacy: Strategies For The 21st Century, Zoë Macdonald

UC Law Journal

Children’s use of social media has been linked to an overwhelming number of adverse effects on their mental health, privacy, and well-being. There is a general consensus among parents, researchers, and lawmakers that children’s online protections must be expanded. However, recent legislative efforts to effect change have been met with consistent failure. Recently, California, Arkansas, and Texas passed new legislation intended to bolster existing protections and expand child privacy online. The Arkansas law and portions of the California and Texas laws do not pass constitutional muster under current case law, and all three federal district courts articulated their inability to …

Perceptual Complexity As Normalized Shannon Entropy, Norberto M. Grzywacz

Psychology: Faculty Publications and Other Works

Complexity is one of the most important variables in how the brain performs decision making based on esthetic values. Multiple definitions of perceptual complexity have been proposed, with one of the most fruitful being the Normalized Shannon Entropy one. However, the Normalized Shannon Entropy definition has theoretical gaps that we address in this article. Focusing on visual perception, we first address whether normalization fully corrects for the effects of measurement resolution on entropy. The answer is negative, but the remaining effects are minor, and we propose alternate definitions of complexity, correcting this problem. Related to resolution, we discuss the ideal …

Earliest Ancient Maya Salt Production In Southern Belize: Excavations At Jay-Yi Nah, Heather Mckillop, E. Cory Sills

Faculty Publications

Salt works along the Yucatan coasts of Mexico and Belize provide a record of salt production for inland trade during the height of Late Classic Maya civilisation (AD 550-800). At the Paynes Creek Salt Works in Belize, production focused on the creation of salt cakes by boiling brine in pots supported over fires in dedicated salt kitchens. Underwater excavations at the Early Classic (AD 250-550) site of Jay-yi Nah now indicate there was a longer and evolving tradition of salt making in the area, one that initially employed large, incurved bowls to meet local or down-the-line trade needs before inland …

Evaluating Donor-Recipient Sex Mismatch In Anterior Cruciate Ligament Reconstruction With Allograft: Outcomes At 2 Years Postoperatively, Connor Crutchfield, Natalie Lowenstein, Chilan Leite, Christian Lattermann, Elizabeth Matzkin

SKMC Student Presentations and Publications

BACKGROUND: Female patients tend to suffer a greater risk of reinjury and worse patient-reported outcome measures (PROMs) after anterior cruciate ligament reconstruction (ACLR) than male patients, regardless of the graft type used.

PURPOSE/HYPOTHESIS: This study explored the role of donor-recipient sex mismatching to help explain these sex-based dispar- ities in outcomes after ACLR with an allograft. The hypothesis was that allograft donor-recipient sex mismatch would adversely affect surgical outcomes at a 2-year follow-up, with male-to-female graft donations yielding the lowest rates of success.

STUDY DESIGN: Cohort study; Level of evidence, 3.

METHODS: Patients who underwent primary ACLR with an allograft …

Childhood Religious Participation As Mediator For Posttraumatic Symptoms And A Joyful Disposition In Adulthood, Kara S. Mccoy

Walden Dissertations and Doctoral Studies

Individuals who have experienced trauma may have varying life experience outcomes based on trauma histories and other factors. Little to no study has been done to determine whether childhood religious involvement can be a mediating factor. The purpose of this quantitative study was to test if any potential mediating effects exist between childhood religious attendance, the presence of joyfulness in life, and adult posttraumatic symptoms. The theoretical framework utilized in this study was Kenneth Pargament’s theory of religious coping. Data were collected in a secure fashion utilizing Survey Monkey, and all participants voluntarily answered questions that utilized the short posttraumatic …

Cultivating Consumption Of Biobased Product, Nima Nejadrezaei

Doctoral

Consumers play a critical role in transitioning towards bioeconomy. However, their positive attitudes and interest in biobased products often do not lead to actual usage because of the complexity of the decision-making process. Despite the bioeconomy’s importance, research on consumer behaviour regarding biobased products remains limited. This study bridged gaps by examining consumer perspectives on biobased products. It sought to identify factors influencing consumer perspectives and develop an integrative model where acceptance preceded actual use. Focusing on consumers from the Republic of Ireland, a test market with strong government commitment to the bioeconomy, private sector and research centre investments and …

Characterizing Phosphorus Removal And Recovery Performance Of A 3d Printed Iron-Embedded Polylactic Acid Composite, Colin B. Wilson, Anthony J. Parolari, Andrew Hiestand, Brooke K. Mayer, Allison Murray

Civil and Environmental Engineering Faculty Research and Publications

Green infrastructure (GI) has been heralded as a solution for reducing phosphorus (P) pollution through increasing stormwater runoff infiltration and improving water quality. Despite its global implementation, GI struggles to improve the effluent water quality discharged from these systems consistently. This research evaluates the P removal performance and recovery potential of iron-embedded polylactic acid (PLA) composites through a novel application of three-dimensional (3D) printed representative unit cells (RUC) that could be used to improve effluent quality in GI. The RUC required chemical oxidation to convert the embedded iron to hematite (Fe₂⁢O₃) to facilitate P adsorption. Batch …

Review Of Before Borders: A Legal And Literary History Of Naturalization, Melissa J. Ganz

English Faculty Research and Publications

No abstract provided.

Writ 101.19: College Writing I Plus, Jennifer A. Corbin

University of Montana Course Syllabi, 2021-2025

No abstract provided.