Digital Commons Network^™

Differential Impact Of Lymphatic Outflow Pathways On Cerebrospinal Fluid Homeostasis, Zachary Papadopoulos, Leon C D Smyth, Igor Smirnov, Daniel A Gibson, Jasmin Herz, Jonathan Kipnis

2020-Current year OA Pubs

Dysfunctional lymphatic drainage from the central nervous system (CNS) has been linked to neuroinflammatory and neurodegenerative disorders, but our understanding of the lymphatic contribution to CNS fluid autoregulation remains limited. Here, we studied forces that drive the outflow of the cerebrospinal fluid (CSF) into the deep and superficial cervical lymph nodes (dcLN and scLN) and tested how the blockade of lymphatic networks affects CNS fluid homeostasis. Outflow to the dcLN occurred spontaneously in the absence of lymphatic pumping and was coupled to intracranial pressure (ICP), whereas scLN drainage was driven by pumping. Impaired dcLN drainage led to elevated CSF outflow …

Impacts Of Changing Temperatures On The Water Budget In The Great Salt Lake Basin, Grace Affram, Jihad Othman, Reza Morovati, Saddy Pineda Castellanos, Sajad Khoshnoodmotlagh, Diana Dunn, Braedon Dority, Katherine Osorio Diaz, Cody Ratterman, Wei Zhang

Plants, Soils and Climate Student Research

Quantifying the water budget in the Great Salt Lake (GSL) basin is a nontrivial task, especially under a changing climate that contributes to increasing temperatures and a shift towards more rainfall and less snowfall. This study examines the potential impacts of temperature thresholds on the water budget in the GSL, emphasizing the influence on snowmelt, evapotranspiration (ET), and runoff under varying climate warming scenarios. Current hydrological models such as the Variable Infiltration Capacity (VIC) model use a universal temperature threshold to partition snowfall and rainfall across different regions. Previous studies have argued that there is a wide range of thresholds …

The Effect Of Cigarette Smoking And Heated Tobacco Products On Different Denture Materials; An In Vitro Study., Sara Fikry, Mahmoud Ankily Dr, Fatma Makkeyah Dr, Mohamed Shamel Dr, Eman Khedr Dr, Sara Motaz Dr, Ayman Amin Dr

Dentistry

Abstract Purpose This study compares the effect of conventional cigarette smoke versus heated tobacco on the discoloration, surface roughness, and bacterial colonization of different oral prosthesis materials. Materials and methods A total of one hundred and twenty disc-shaped samples made of four different denture base materials were prepared to represent different denture bases to assess the surface roughness and biofilm formation; group (CA): conventional heat-cured acrylic resin (Acrostone, Egypt), group (FA): flexible acrylic resin (Valplast International Corp, USA), group (TA): heat-cured acrylic resin reinforced with titanium nanoparticles (TA nanoparticles, Nanogate, Egypt), and group (PA): 3D printed acrylic resin (Nexdent, The …

Defining The Role Of Adjuvant Radiotherapy For Biliary Tract Cancers: A Site-Specific Propensity-Matched Analysis, Yongwoo David Seo, Belkacem Acidi, Andrew Newton, Antony Haddad, Yi-Ju Chiang, Rainna Coelho, Timothy E Newhook, Ching-Wei D Tzeng, Yun Shin Chun, Ethan B Ludmir, Eugene J Koay, Milind Javle, Jean Nicolas Vauthey, Hop S Tran Cao

Faculty, Staff and Student Publications

Background: Biliary tract cancers (BTCs) have distinct tumor biology but share a poor prognosis, with a 5-year-survival-rate of 5-19%. Surgical resection is the only potential cure, but recurrences are common. The role of adjuvant radiotherapy (XRT) remains unclear.

Methods: Using the National Cancer Database (2006-2018), we analyzed resected non-metastatic BTCs. Patients who survived beyond 90 days post-surgery were included, while those with R2 resections or neoadjuvant therapy were excluded. Propensity matching was performed based on predictors of adjuvant radiation, age, and sex. Survival outcomes were compared between no adjuvant therapy, chemotherapy alone, and XRT ± chemotherapy.

Results: …

Investigating The In Vivo Effects Of Anti-Prion Protein Nanobodies On Prion Disease With Aav Vector, Jingjing Zhang, Mengfei Wang, Dan Wang, Xiangyi Zhang, Yue Ma, Els Pardon, Jan Steyaert, Romany Abskharon, Fei Wang, Jiyan Ma

Faculty, Staff and Student Publications

Prion diseases are fatal neurodegenerative disorders affecting humans and animals, and the central pathogenic event is the conversion of normal prion protein (PrPC) into the pathogenic PrPSc isoform. Previous studies have identified nanobodies that specifically recognize PrPC and inhibit the PrPC to PrPSc conversion in vitro. In this study, we investigated the potential for in vivo expression of anti-PrPC nanobodies and evaluated their impact on prion disease. The coding sequences of three nanobodies were packaged into recombinant adeno-associated virus (rAAV) and were administered via intracerebroventricular (ICV) injection in newborn mice. We found that the expression of these nanobodies remained robust …

Dairy Consumption And The Colonic Mucosa-Associated Gut Microbiota In Humans-A Preliminary Investigation, Ellie Chen, Nadim J Ajami, Donna L White, Yanhong Liu, Shawn Gurwara, Kristi Hoffman, David Y Graham, Hashem B El-Serag, Joseph F Petrosino, Li Jiao

Faculty, Staff and Students Publications

Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota.

Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut microbiota and the self-reported intake of total dairy, milk, cheese, and yogurt. A total of 97 colonic mucosal biopsies collected from 34 polyp-free individuals were analyzed. Dairy consumption in the past year was assessed using a food frequency questionnaire. The 16S rRNA gene V4 region was amplified and sequenced. Operational taxonomic unit (OTU) classification was performed using the UPARSE and SILVA databases. OTU diversity and relative abundance were compared …

Cardiovascular Disease In Adults With Osteogenesis Imperfecta: Clinical Characteristics, Care Recommendations, And Research Priorities Identified Using A Modified Delphi Technique, Lars Folkestad, Siddharth K Prakash, Sandesh C S Nagamani, Niels Holmark Andersen, Erin Carter, Jannie Dahl Hald, Riley J Johnson, Bente Langdahl, Eleanor M Perfetto, Cathleen Raggio, Stuart H Ralston, Robert A Sandhaus, Oliver Semler, Laura Tosi, Eric Orwoll

Faculty, Staff and Student Publications

Osteogenesis imperfecta (OI) is a multisystem disorder most often caused by pathogenic variants in genes that encode type I collagen. Type I collagen is abundant not only in bone but also in multiple tissues including skin, tendons, cornea, blood vessels, and heart. Thus, OI can be expected to affect cardiovascular system, and there are numerous reports of cardiovascular disease (CVD) in people with OI. However, there is no consensus on how CVD in OI should be assessed or managed. To fill this gap, a multidisciplinary group was convened to develop clinical guidance. The work included a systematic review of the …

Volume 37-1 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 37-1 Complete Issue

Place And Cultural Identity Among Guatemalan Indians: "The Fragility Of Goodness", Edward Davis

The Geographical Bulletin

Place experience may be more important to culture groups in war-torn and impoverished countries than to those in stable, developed regions. There is evidence from diverse sources that place experiences are directly relevant to the distinct Indian identities found within Guatemala's western highlands. Individual municipios often are distinct in their clothing, language and attachment to the land. A rereading of ethnographies gathered during the last few decades, along with new survey data, suggest that place and identity are strongly linked, possibly in part as a response to a history of violence and oppression in the region.

A Review On Exploring Artificial Intelligence Applications, Advancements, Issues, And Future Challenges, Sajid Naeem, Novman Nabeel, Waseem Beg, Shujaat Ali, Rajiv N. Kanojiya, Satish S. Mandawade, Chetan R. Yewale, Sc Kulkarni, Vt Salunke, Av Patil

Polytechnic Journal

Artificial intelligence (AI) is a transformative technology with diverse applications that is transforming several industries. AI is the use of systems and technology to replicate human intelligence and solve common real-world issues. Machine learning (ML) and deep learning are AI technologies that use algorithms to more accurately predict occurrences without the need for human intervention. Explainable Artificial Intelligence (XAI) refers to AI that can explain decisions or forecasts to human users. XAI seeks to improve AI systems' transparency, trustworthiness, and accountability, particularly when utilized in high-risk applications such as healthcare, finance, or security. This review article provides a thorough overview …

Woody Plant Reinvasion Shortens The Lifespan Of Grassland Restoration Treatments, Dillon T. Fogarty, Michele Beadle, Craig R. Allen, Christine Bielski, Dirac Twidwell

Biology Student Work

An important question in restoration ecology is whether restored ecological regimes are more vulnerable to transitions back to a degraded state. In woody-invaded grasslands, high-intensity fire can collapse woody plant communities and induce a shift back to a grass-dominated regime. Yet, legacies from woody-dominated regimes often persist and it remains unclear whether restored regimes are at heightened vulnerability to reinvasion. In this study, we utilize a 17-year history of fire-based restoration in Nebraska's Loess Canyons Experimental Landscape to determine whether restored grassland regimes experience faster rates of Juniperus virginiana (eastern redcedar) reinvasion compared to the initial invasion process in adjacent …

Effects Of Initial Foot Position On Neuromuscular And Biomechanical Control During The Stand-To-Sit Movement: Implications For Rehabilitation Strategies, Woohyoung Jeon, Ashley Dalby, Xuanliang Neil Dong, Chung-Hyun Goh

Health & Kinesiology Faculty Publications and Presentations

Background: Initial foot position (IFP) is one of the important movement strategies that influence neuromuscular and biomechanical control during sit-to-stand (STS) movements. Similarly, stand-to-sit (StandTS) is vital in rehabilitation settings for evaluating strength and balance control during descending movements. Understanding how IFP impacts changes in biomechanical and neuromuscular movement control factors during StandTS can provide valuable insights for designing effective rehabilitation programs.

Methods: Twelve healthy young adults participated in this study, examining three symmetric IFPs: (1) REF (reference); (2) wide: each foot was shifted outwards by 30% from REF; (3) TO (toes-out): symmetric toes-out angle of 30° from REF. Kinematic …

February 2025 Quicknotes, Southern Adventist University

QuickNotes – Advancement e-Newsletter

QuickNotes is an e-newsletter that comes from Advancement at Southern Adventist University. The February 2023 edition features information the ivory comb exhibit, MLK Service Day, and a new scholarship.

Magnetus: A Magnetized Plasma Research Ecosystem, N. C. Hurst, M. Abler, Michael R. Brown, J. Juno, E. G. Kostadinova, N. A. Murphy, J. Olson, D. M. Orlov, D. B. Schaeffer, D. A. Schaffner, E. E. Scime, T. M. Tenbarge, S. C. Thakur

Physics & Astronomy Faculty Works

MagNetUS is a network of scientists and research groups that coordinates and advocates for fundamental magnetized plasma research in the USA. Its primary goal is to bring together a broad community of researchers and the experimental and numerical tools they use in order to facilitate the sharing of ideas, resources and common tasks. Discussed here are the motivation and goals for this network and details of its formation, history and structure. An overview of associated experimental facilities and numerical projects is provided, along with examples of scientific topics investigated therein. Finally, a vision for the future of the organization is …

Uaa Report And Findings, National Technology & Engineering Solutions Of Sandia, Llc (Ntess) And Department Of Energy (Doe)

Tijeras Arroyo Use Attainability Analysis

Between 2018 and 2023 NTESS and DOE conducted a UAA for the Rio Grande to Four Hills Reach of Tijeras Arroyo (AU NM-9000.A_070). The UAA was conducted to formally evaluate whether the Rio Grande to Four Hills Bridge reach of Tijeras Arroyo exhibits characteristics of an ephemeral water body under 20.6.4.97 NMAC. Based on the information presented in the UAA, the Rio Grande to Four Hills Bridge reach of Tijeras Arroyo (AU NM-9000.A_070) exhibits characteristics of an ephemeral water body. NTESS and DOE intend to petition the New Mexico Water Quality Control Commission for an amendment of the reach’s classification …

Research Update - February 2025, Office Of Research

Research Update

No abstract provided.

Daily Announcements February 2025, Wofford College. Office Of Marketing And Communications

Communications Office Daily Announcements

No abstract provided.

Uaa Public Involvement, National Technology & Engineering Solutions Of Sandia, Llc (Ntess) And Department Of Energy (Doe), U.S. Department Of Energy

Tijeras Arroyo Use Attainability Analysis

Between 2018 and 2023 NTESS and DOE conducted a UAA for the Rio Grande to Four Hills Reach of Tijeras Arroyo (AU NM-9000.A_070). The UAA was conducted to formally evaluate whether the Rio Grande to Four Hills Bridge reach of Tijeras Arroyo exhibits characteristics of an ephemeral water body under 20.6.4.97 NMAC. Based on the information presented in the UAA, the Rio Grande to Four Hills Bridge reach of Tijeras Arroyo (AU NM-9000.A_070) exhibits characteristics of an ephemeral water body. NTESS and DOE intend to petition the New Mexico Water Quality Control Commission for an amendment of the reach’s classification …

Operationalizing And Measuring Climate Change Adaptation Success, Henry A. Bartelet, Michele L. Barnes, Lalu A.A. Bakti, Graeme S. Cumming

Quantitative Methods and Information Technology Faculty Publications

In a context of rapid global change, understanding whether and how adaptation to climate change can be considered successful has become an important research gap within the climate change adaptation literature. Although definitions of adaptation success have been formulated, it remains unclear how they can be operationalized and tested empirically. To address this gap, we operationalized one of the most prominent definitions of successful adaptation within the academic literature, which describes success as adaptations that support reductions in risk and vulnerability without compromising sustainability. Specifically, drawing on data collected from 209 coral reef tourism operators across 28 locations and eight …

3d Printing Insect Models For K-12 Education, Henry L. Whittemore, Jason Oliver, Karla M. Addesso

Extension Publications

No abstract provided.

An Approach To Estimate Angling Effort, Catch, And Harvest Of Burbot Lota Lota, Collin J. Mitchell

Biology Graduate Theses

Once commonly thought of as a nuisance, Burbot Lota lota are now being frequently targeted by anglers in Minnesota. However, the amount of angling effort directed at Burbot, the distribution of effort, catch, and harvest are unknown. Historically, creel surveys have been used to estimate angling effort, catch, and harvest. Additionally, digital cameras have been used independently and supplementally to estimate angling effort, catch, and harvest. In this study, we estimate angling effort, catch, and harvest of Burbot using creel survey techniques and motion-activated digital cameras on Bad Medicine Lake, Minnesota, while also investigating and exploring the limitations of these …

A Numerical Assessment Of Ocean Alkalinity Enhancement Efficiency On A River-Dominated Continental Shelf—A Case Study In The Northern Gulf Of Mexico, Yanda Ou, Z. George Xue, Xinping Hu

Faculty Publications

A robust high-resolution coupled hydrodynamic-biogeochemical model was applied to the northern Gulf of Mexico to assess the efficiency of river- and ocean-sourced ocean alkalinity enhancement (OAE). Sensitivity tests indicate that the effectiveness of OAE-induced CO2 uptake is primarily influenced by the amount of alkalinity introduced and local wind-driven mixing, with the former determining the overall uptake and the latter affecting short-term variability. Compared to ocean-sourced OAE (direct ocean release), river-sourced OAE (elevated river alkalinity) is more effective and sustainable. River-sourced OAE has higher CO2 uptake efficiency with reduced spatial and temporal uncertainty and greater overall CO2 uptake. For river-sourced OAE, …

An Integrated Global-To-Regional Scale Workflow For Simulating Climate Change Impacts On Marine Ecosystems, Kelly Ortega-Cisneros, Denisse Fierros-Arcos, Max Lindmark, Camilla Novaglio, Phoebe Woodworth-Jefcoats, Tyler D. Eddy, Marta Coll, Elizabeth Fulton, Ricardo Oliveros-Ramos, Jonathan Reum, Yunne Jai Shin, Cathy Bulman, Leonardo Capitani, Samik Datta, Kieran Murphy, Alice Rogers, Lynne Shannon, George A. Whitehouse, Ezekiel Adekoya, Beatriz S. Dias, Alba Fuster-Alonso, Cecilie Hansen, Bérengère Husson, Vidette Mcgregor, Alaia Morell, Hem Nalini Morzaria Luna, Jazel Ouled-Cheikh, James Ruzicka, Jeroen Steenbeek, Ilaria Stollberg, Roshni C. Subramaniam, Vivitskaia Tulloch, Andrea Bryndum-Buchholz

Faculty Publications

As the urgency to evaluate the impacts of climate change on marine ecosystems increases, there is a need to develop robust projections and improve the uptake of ecosystem model outputs in policy and planning. Standardizing input and output data is a crucial step in evaluating and communicating results, but can be challenging when using models with diverse structures, assumptions, and outputs that address region-specific issues. We developed an implementation framework and workflow to standardize the climate and fishing forcings used by regional models contributing to the Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) and to facilitate comparative analyses across …

Family Structure And Parents’ Perceptions Of The Importance Of Youth Developmental Assets: Challenging The Deficit Orientation Of Structurally Diverse Families, Jonathon J. Beckmeyer, Luke T. Russell, Gabrielle C. Kline

Faculty Publications - Family and Consumer Sciences

Critical family scholars have highlighted that structurally diverse families (e.g. stepfamilies, single-parent families) are often unfairly viewed through a deficit-comparison lens. This includes assumptions that these families are less optimal contexts for raising children than married different-sex nuclear families or hold different parenting and family values. In the present study, we sought to challenge that assumption by having parents rate the importance of developmental assets for their adolescent children and then comparing perceived importance across family structures. To do so we used data from 354 parents (24.6% single-parent families, 16.7% stepfamilies, 58.8% two-biological/adoptive parent families). We found that the overwhelming …

Tremblings, February 2025, Western Aspen Alliance

Tremblings

Bridging Conservation Science With Native Meaning

James Calabaza, Indigenous Lands Director; Trees, Water & People

Last fall, I had the privilege of collaborating with the Western Aspen Alliance and other partners to carry out a 3-day workshop focused on quaking aspen genetics, fire ecology, and co-stewardship. Held at Rocky Mountain Biological Laboratory (Gothic, Colorado), the workshop brought together academics, NGOs, federal agencies, and Tribal members to share diverse perspectives on aspen's significance and management futures.

February 2025 Cafe Newsletter, Center For Advancing Faculty Excellence

CAFE Faculty Newsletters

No abstract provided.

What We Mean When We Say Semantic: Toward A Multidisciplinary Semantic Glossary, Jamie Reilly, Cory Shain, Valentina Borghesani, Philipp Kuhnke, Gabriella Vigliocco, Jonathan E. Peelle, Bradford Z. Mahon, Laurel J. Buxbaum, Asifa Majid, Marc Brysbaert, Anna M. Borghi, Simon De Deyne, Guy Dove, Liuba Papeo, Penny M. Pexman, David Poeppel, Gary Lupyan, Paulo Boggio, Gregory Hickok, Laura Gwilliams, Leonardo Fernandino, Daniel Mirman, Evangelia G. Chrysikou, Chaleece W. Sandberg, Sebastian J. Crutch, Liina Pylkkänen, Eiling Yee, Rebecca L. Jackson, Jennifer M. Rodd, Marina Bedny, Louise Connell, Markus Kiefer, David Kemmerer, Greig De Zubicaray, Elizabeth Jefferies, Dermot Lynott, Cynthia S. Q. Siew, Rutvik H. Desai, Ken Mcrae, Michele T. Diaz, Marianna Bolognesi, Evelina Fedorenko, Swathi Kiran, Maria Montefinese, Jeffrey R. Binder, Melvin J. Yap, Gesa Hartwigsen, Jessica Cantlon, Yanchao Bi, Paul Hoffman, Frank E. Garcea, David Vinson

Moss-Magee Rehabilitation Papers

Tulving characterized semantic memory as a vast repository of meaning that underlies language and many other cognitive processes. This perspective on lexical and conceptual knowledge galvanized a new era of research undertaken by numerous fields, each with their own idiosyncratic methods and terminology. For example, "concept" has different meanings in philosophy, linguistics, and psychology. As such, many fundamental constructs used to delineate semantic theories remain underspecified and/or opaque. Weak construct specificity is among the leading causes of the replication crisis now facing psychology and related fields. Term ambiguity hinders cross-disciplinary communication, falsifiability, and incremental theory-building. Numerous cognitive subdisciplines (e.g., vision, …

Childhood Religious Participation As Mediator For Posttraumatic Symptoms And A Joyful Disposition In Adulthood, Kara S. Mccoy

Walden Dissertations and Doctoral Studies

Individuals who have experienced trauma may have varying life experience outcomes based on trauma histories and other factors. Little to no study has been done to determine whether childhood religious involvement can be a mediating factor. The purpose of this quantitative study was to test if any potential mediating effects exist between childhood religious attendance, the presence of joyfulness in life, and adult posttraumatic symptoms. The theoretical framework utilized in this study was Kenneth Pargament’s theory of religious coping. Data were collected in a secure fashion utilizing Survey Monkey, and all participants voluntarily answered questions that utilized the short posttraumatic …

The Role Of Marine Co2 Removal In Combating Climate Change, Sarah Vican, Meghan Gavin, Wil Burns, Douglas Edwards, Romany M. Webb

Sabin Center for Climate Change Law

Combating climate change requires not only rapid reduction of greenhouse gas emissions, but also removal of significant amounts of carbon dioxide (CO2) from the atmosphere. CO2 removal (CDR) comes in many different forms, but climate scientists and policymakers are focusing on the potentially important role of large-scale use of emerging ocean-based techniques, often referred to as marine CDR (mCDR). In the United States, mCDR in domestic waters is governed by a patchwork of laws and regulations. There are also major uncertainties concerning regulation of mCDR in the open ocean, where international treaty regimes have struggled to develop coherent rules. On …

Reducing Pollution From Concentrated Animal Feeding Operations By Enforcing National Pollutant Discharge Elimination System Permit Requirements Under The Clean Water Act, Shelby White

Colorado Environmental Law Journal

No abstract provided.