Digital Commons Network^™

Monroe Work's Contributions To Public Sociology, Leonard A. Steverson, Gabrielle S. Kelly, Emma R. Torres

The Journal of Public and Professional Sociology

Abstract

Monroe Work was a Chicago School trained sociologist, criminologist, and researcher who, despite not being well-known in the social sciences, produced a body of research that is exemplified in what is now known as public sociology. Work was associated with prominent sociologist and activist W.E.B. Du Bois while working in Savannah, Georgia, and later with Booker T. Washington, with whom he worked at the Tuskegee Institute, heading the records and research department. Work was a talented researcher who worked behind the scenes with both Du Bois and Washington to provide needed research in a time of intense racial conflict. …

Opioid Use Disorder In Region 9 Of Louisiana: Using Labeling Theory To Understand The Layperson's Perception, Sara Elizabeth Dupree-Wolf

Walden Dissertations and Doctoral Studies

The overall research problem in this research study was that there were no current data related to the layperson's perception of opioid use disorder using labeling theory in Region 9 of Louisiana. This study is essential because opioid use disorder affects people worldwide, and the number of people diagnosed with opioid use disorder rises annually. Annually, thousands of people overdose, with a plethora of these overdoses resulting in death, due to opiate use. These deaths are unnecessary because there are treatment options and resources available. However, stigma and fear keep people from accessing potentially lifesaving resources. The purpose was to …

A Mechanistic Exploration Of How Neighborhood Crime Exposure Relates To Neonatal Brain Function, Early Externalizing Behaviors, And Callous-Unemotional Traits, Rebecca Brady

Arts & Sciences Graduate Student Theses and Dissertations

Pregnancy through early childhood is a period of tremendous neural and behavioral development. Neuronal birth and migration occur prenatally and result in the formation of neonatal functional and structural networks. These early brain networks are a building block for postnatal development wherein infants rapidly learn a variety of new skills, including socioemotional skills such as emotion regulation and moral understanding. During the acquisition of these skills, even typically developing toddlers can act aggressively or impulsively; however, toddlers with high levels of externalizing behaviors are more likely to develop clinical externalizing disorders later in childhood and adolescence. As such, it is …

A Pilot Academic Support Mechanism For Biomedical Sciences Graduate Program Students, Julie G. In, Kathryn M. Frietze

HSC Education Days

No abstract provided.

Ecological Influences On Informal Property Rights: Experimental Evidence, Erik O. Kimbrough

Economics Faculty Articles and Research

This paper explores the possibility that informal property right systems evolve unique features as a function of the characteristics of the resources over which they are established. We develop an experimental environment that allows us to test this hypothesis by comparing the emergence of property in (virtual) land when resource yields are either high- or low-variance and renewable or non-renewable. Previous research suggests that high-variance resources may lead to relatively insecure claims to property. Intuition suggests that this may be amplified when those resources are renewable. The experiments confirm that informal property rights adapt to resource characteristics in a manner …

Impact Of Developmental State, P53 Status, And Interferon Signaling On Glioblastoma Cell Response To Radiation And Temozolomide Treatment, Artem D. Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais S. Sabedot, Katherine Gurdziel, Susan M. Irtenkauf, Laura A. Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen L. Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila M. Poisson, Houtan Noushmehr, Douglas Ruden, Ana C. De Carvalho

Neurosurgery Articles

Glioblastoma (GBM) tumors exhibit extensive genomic, epigenomic, and transcriptional diversity, with significant intratumoral heterogeneity, complicating standard treatment approaches involving radiation (RT) and the DNA-alkylating agent temozolomide (TMZ). In this study, we employed an integrative multi-omics approach, including targeted proteomics, transcriptomics, genomics, and DNA methylation profiling, to investigate the response of a representative panel of GBM patient-derived cancer stem cells (CSCs) to astrocytic differentiation and RT and TMZ treatments. Differentiated CSC progenies retained the expression of key stemness genes and survival pathways, while activating the BMP-Smad signaling pathway and upregulating extracellular matrix components. This was associated with increased resistance to TMZ, …

The Diamond, February 7, 2025, Dordt University

Dordt Diamond

• Front Page: Dordt Theatre Department Attends KCACTF 57; Saved by Grace: Rival Teams United in Remembrance of Aden De Jong; Dordt Students React to Airliner Plane and Helicopter Crash in Washington DC
• News: New Locations for PLIA Trips; Op-Ed: Winter Boots, Virtue Signals, and Censorship?
• Feature: "Learning About Movies" Dr. Matthews' Online Engagement with Cinema; "Flow with the Father" Kicks Off New Women's Ministry; Senior Spotlights; Dordt Sustainability Efforts
• Opinion: The Bachelor - It's Back on TV, But Why?; Nosferatu Review; A Broken Cycle: Laundry at Dordt Needs to Change; Why Do the Chiefs Keep Winning? …

Implementation Of Resiliency Training In The Biomedical Science Graduate Program First Year Curriculum, Kathryn M. Frietze

HSC Education Days

No abstract provided.

Alternative Antimicrobial Strategies For Neonatal Infections, Anna Desmond

Theses

Neonatal infections, a significant contributor to infant morbidity and mortality worldwide, are predominantly caused by pathogenic bacteria. Globally, bacterial sepsis accounts for 11.3% of neonatal deaths with Group B Streptococcus (GBS) being the leading cause, along with Escherichia coli, and coagulase negative staphylococci (CoNS). Neonatal infections caused by antibiotic resistant bacteria is now a worldwide concern, further increasing mortality rates and associated healthcare costs. Therefore, there is an urgent need to develop alternative antimicrobial strategies to combat resistance and/or enhance the efficacy of existing antibiotics. The overall aim of this thesis was to investigate alternative antimicrobial strategies for treating and …

Options For Sustainable High Seas Fisheries Management In The Southwest Atlantic, Cornell Overfield, Jessica Yllemo

International Law Studies

The Southwest Atlantic lacks a regional fishery management organization, leaving one of the world’s largest squid fisheries at risk of overfishing during high seas migrations. This article reviews measures available to coastal States as they seek to protect regional ecosystems and their economic interests. The ideal policy response is to conclude a regional fisheries management organization covering squid and other key regional stocks. This body should follow best practices and include the relevant coastal and fishing States. Other options that provide some value for managing regional fishing and its environmental consequences include reviving and expanding catch information sharing, ratifying and …

Tdp43 Negtively Regulates Tbk1-Medicated Ifn1 Production Through Irf7 Pathway In Neurodegenerative Diseases, Wenjuan Zhang, Zhen Yi, Daihe Yang, Yifan Hao, Feng Zhou, Guohua Song, Cao Huang, Yun Zhou, Bo Huang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mutations in the genes encoding TAR DNA-binding protein 43 (TDP43) or TANK- binding kinase 1 (TBK1) have been strongly associated with neurological disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. TDP43 is a key component of pathological protein aggregates found in more than 90% of ALS cases, while TBK1 plays a critical role in innate immune signaling and autophagy. Despite these associations, the precise molecular mechanisms linking TDP43 or TBK1 dysfunction to neurodegeneration remain poorly understood. The present study examined the impact of TDP43 on TBK1-mediated type I interferon (IFN1) production in HEK-293T cells. The findings demonstrated that co-expression …

Additional Geographic Records Of Dekay’S Brownsnake (Storeria Dekayi) In Nebraska, Including A Late Seasonal Observation And Likely Range Expansion, Lauren Bahe, Dan D. Fogell, Keith Geluso

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Dekay’s Brownsnake (Storeria dekayi) occurs across much of eastern North America, inhabiting diverse environments such as marshes, woodlands, woodland edges, and urban areas. In Nebraska, recent studies documented its presence beyond the extreme southeastern region of the state, indicating a potential range expansion to the west and north. Our study continues to update its distribution with four additional county records. Two counties, Franklin and Harlan, represent the farthest west observations for Dekay’s Brownsnake in the state, further indicating a likely westward expansion. An observation from 6 December 2023 also represents the latest seasonal observation in the state. Despite …

Predictors Of Treatment Adherence Among Individuals With Bipolar Disorder And Comorbid Substance Use Disorders, Monique Dawn Romeo

Walden Dissertations and Doctoral Studies

Individuals with bipolar disorder (BD) require lifelong treatment to manage their symptoms, and many also struggle with comorbid substance use disorders (BD-SUD) that complicate treatment adherence. Despite these challenges, there has been limited research on what factors predict successful treatment adherence in this population. This study was thus conducted to identify key predictors of adherence among individuals with BD-SUD. Several factors were examined, including age, gender, type of substance used at admission, opioid medication-assisted therapy, length of stay in inpatient psychiatric care, type of discharge service, and participation in self-help groups before discharge. The study applied a donut model framework …

The Impacts Of Software Development Methodologies On New Model Success Rate In The U.S. Automotive Industry, Marquita Aleatrice Tucker

Walden Dissertations and Doctoral Studies

Since 2017, the U.S. automotive industry has experienced a decrease in new-model launch success rate. A single 12-month delay in a new vehicle launch may cost a manufacturer up to $200 million. One component of automotive product development is software development. The research problem was a lack of understanding of the challenges with software development methodologies from the perspective of software developers, preventing managers from implementing methodologies, policies, and processes to improve the rates of successful new model launches. The purpose and the research questions were focused on exploring the lived experiences of software developers in the U.S. automotive industry …

Probing For Intentions: The Early Readiness Potential Does Not Reflect Awareness Of Motor Preparation, Jake Gavenas, Aaron Schurger, Uri Maoz

Psychology Faculty Articles and Research

Voluntary actions are typically preceded by the readiness potential (RP), a negative midfrontal electroencephalography (EEG) deflection that begins ~2 s before movement. What cognitive and neural process the RP reflects and how it relates to conscious intention remain unclear due to conflicting findings. We investigated the neural basis and cognitive significance of the RP in a novel probe-based paradigm. Contrary to prior reports, we found that pre-probe RP buildups were not related to reported awareness of motor preparation. Computational modeling suggested that the best explanation for these results is via metacognitive access to stochastic accumulation. Reported preparation was also related …

Therapeutic Targeting Of The Janus Kinase/Signal Transducer And Activator Of Transcription Pathway In Cutaneous T-Cell Lymphoma, Alisha Kashyap, Julia Dai, Xiao Ni

Faculty, Staff and Student Publications

Background/Objectives: Cutaneous T-cell lymphoma (CTCL) is a rare group of non-Hodgkin lymphomas characterized by the clonal expansion of malignant T cells. While current treatments can alleviate symptoms and significant progress has been made in treating leukemic CTCL, a definitive cure remains elusive. Dysregulation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is a key driver of CTCL pathogenesis. As a result, therapeutic strategies targeting JAK/STAT signaling have gained momentum, with the increasing use of JAK inhibitors and other agents that effectively suppress this pathway. These immune-modulating therapies have broad effects on physiological processes, inflammation, and …

Child Sexual Abuse And Mental Health: The Role Of Intrusive Thoughts And Spiritual Warfare, Sheriese S. Sanchez

Doctoral Dissertations and Projects

A number of psychological issues are experienced by individuals who have experienced CSA, including depression, anxiety, and bipolar disorder, as well as intrusive thoughts contribute to the perpetuation of the mental health problem. Studies have shown that spiritual practices, such as prayer, meditation, reading the Bible, and reciting scripture affirmations, can improve mental health, improving one’s psychological well-being. Further, intrusive thoughts may be initiated by dark spiritual influences. Despite ongoing research, there is a lack of integration between disciplines of science and biblical truth concerning the impact of immaterial spiritual dimensions on psychological states. To understand intrusive thoughts, one must …

The Communication Theory Of Argumentativeness: A Study Analyzing Argumentativeness And Demographics, Monika Joanna Yates

Doctoral Dissertations and Projects

Quantitative research regarding the communication theory of argumentativeness is presented. The communication theory of argumentativeness, with its established argumentativeness conceptualization, scale, and measure, is central. The argumentativeness conceptualization, scale, and measure are used to posit argumentativeness groupings, which are then analyzed along with demographics within argumentativeness groupings. The following research questions are posed and answered: What is the distribution of argumentativeness within the general population? Are there identifiable segments/groupings of argumentativeness within the general population? Are there certain demographic characteristics that accompany the argumentativeness groupings of low, middle, and high argumentativeness measures? The conclusion finds: there are identifiable argumentativeness groupings; …

Ontological Overtones Of Participatory Soteriology In Romans 8:1-17, Derek E. Wilder

Doctoral Dissertations and Projects

The burgeoning scholarly interest in the concepts of deification and Paul’s “in Christ” participatory soteriology necessitates a deeper exploration of their interrelation with the indwelling of the Holy Spirit. Regardless of the increase in recent scholarship, the connection between participation in Christ and the indwelling of the Holy Spirit remains underexplored. This study examines the relationship between deification, Pauline participatory soteriology, and pneumatology through an exegetical analysis of Romans 8:1–17. This exegetical framework posits that the believer’s union with Christ initiates a profound ontological metamorphosis, actualized through the Holy Spirit’s immanent indwelling and transcendent relational dynamic. The pneumatological dimension of …

Beyond The Closed-Forest Paradigm: Cross-Scale Vegetation Structure In Temperate Europe Before The Late-Quaternary Megafauna Extinctions, Elena A. Pearce, Florence Mazier, Charles W. Davison, Oliver Baines, Szymon Czyzewski, Ralph Fyfe, K Binka, Steve Boreham, Jacques Louis De Beaulieu, Cunhai Gao, Wojciech Granoszewski, Anna Hrynowiecka, Małgorzata Malkiewicz, Tim Mighall, Bożena Noryśkiewicz, Irena Agnieszka Pidek, Jaqueline Strahl, Hanna Winter, Jens Christian Svenning

School of Geography, Earth and Environmental Sciences

The Last Interglacial (∼129,000–116,000 years ago) provides key insights into temperate European vegetation dynamics before significant anthropogenic impacts. Using LOVE (Local Vegetation Estimates) and REVEALS (Regional Estimates of VEgetation Abundance from Large Sites) models, this study reconstructs vegetation patterns across local (∼9 km²) and regional (∼100 km²) scales. Local landscapes presented a heterogeneous mosaic, with averages of 17 % open vegetation, 21 % closed forests, and 63 % light woodlands, reflecting high fine-scale heterogeneity. Importantly, weak local-regional correlations highlight the importance of localised drivers. Longitude and, to a lesser extent, precipitation explained some variation in local vegetation openness, but heterogeneity …

A Statistical Framework For Multi-Trait Rare Variant Analysis In Large-Scale Whole-Genome Sequencing Studies, Xihao Li, Han Chen, Margaret Sunitha Selvaraj, Eric Van Buren, John Blangero, Joanne E. Curran, Michael C. Mahaney, Ravi Duggirala, Juan M. Peralta, Harald Hh Goring

School of Medicine Publications

Large-scale whole-genome sequencing (WGS) studies have improved our understanding of the contributions of coding and noncoding rare variants to complex human traits. Leveraging association effect sizes across multiple traits in WGS rare variant association analysis can improve statistical power over single-trait analysis, and also detect pleiotropic genes and regions. Existing multi-trait methods have limited ability to perform rare variant analysis of large-scale WGS data. We propose MultiSTAAR, a statistical framework and computationally scalable analytical pipeline for functionally informed multi-trait rare variant analysis in large-scale WGS studies. MultiSTAAR accounts for relatedness, population structure and correlation among phenotypes by jointly analyzing multiple …

Corn Tolerance To Florpyrauxifen-Benzyl Rates And Its Mixture With Atrazine And Mesotrione, Amar Godar, Jason K. Norsworthy, L. Tom Barber

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Florpyrauxifen-benzyl is a new synthetic auxin herbicide labeled in rice with a broad spectrum of control, typically more potent on broadleaf weeds. It has garnered some interest as a potential broadleaf weed control option for use in corn at low rates. Field experiments were conducted in Fayetteville, Arkansas, from 2019 through 2021 to examine the response of corn to postemergence applications of florpyrauxifen-benzyl at three rates (7.5, 15, and 30 g ae ha-1), as well as mixtures of the herbicide with atrazine (at half or full rate), mesotrione, or a combination of atrazine (at half rate) and mesotrione. Injury and …

Worldview And Moral Injury: An Exploratory Multiple Case Study On Behavioral Health Providers’ Descriptions Of Moral Injury, Mark C. Lane Jr

Doctoral Dissertations and Projects

The concept of Moral Injury continues to gain research traction in the helping professional fields. Researchers continue to debate different components of Moral Injury. Defining, assessing, and treating Moral Injury captures much of the psychological literature. Despite this, standardized holistic conceptualization and treatment have yet to be realized. Worldview influences all aspects of every endeavor in human life. As such, this qualitative exploratory multiple case study from a Christian post-positivist position explored how Department of Defense or Veteran Affairs behavioral health providers’ worldview influences their descriptions of the construct of Moral Injury, its morbidity, and how behavioral health providers choose …

Understanding The Relationship Between Food And Connection To God, Angela M. Hall

Doctoral Dissertations and Projects

A person’s relationship with God is a personal one, as is the choice of the food we eat. Today we see more and more people struggle with unhealthy relationships with food. And our relationship with food affects more than just our physical health. Food and diet can play a role in how we hear from God. The present qualitative study aimed to understand the relationship between food and connection to God. Specifically, this study aimed to explain lived experiences with food and if diet affected connection to God. A total of twelve Christian, adult men and women participated in 1:1 …

Fort Hays State University Tiger Weekly, February 08, 2025, University Relations

Tiger Weekly Newsletters

No abstract provided.

A Synthetic Chronogenetic Gene Circuit For Programmed Circadian Drug Delivery, Lara Pferdehirt, Anna R Damato, Kristin L Lenz, Maria F Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D Herzog, Farshid Guilak

2020-Current year OA Pubs

Circadian medicine, the delivery of therapeutic interventions based on an individual's daily rhythms, has shown improved efficacy and reduced side-effects for various treatments. Rheumatoid arthritis and other inflammatory diseases are characterized by diurnal changes in cytokines, leading to inflammatory flares, with peak disease activity in the early morning. Using a combination of synthetic biology and tissue engineering, we developed circadian-based gene circuits, termed "chronogenetics", that express a prescribed transgene downstream of the core clock gene promoter, Period2 (Per2). Gene circuits were transduced into induced pluripotent stem cells that were tissue-engineered into cartilage constructs. Our anti-inflammatory chronogenetic constructs produced therapeutic concentrations …

Taking Point: Getting Dual Enrollment Programs Started In Your State, Shadh Molla

ERAU SMART@ER Educators Conference

While the GAI Dual-Enrollment program is a smashing success, running in many Florida high schools, it is only beginning to take hold in other states. This session will explore how the program got started in the state of Ohio, and how it has expanded. Attendees will be equipped with tips and strategies to get the ERAU/GAI Dual-Enrollment started in their own states. Session repeated on Friday at 11:00.

2025 Sdsu Data Science Symposium Workshop Abstracts, South Dakota State University

SDSU Data Science Symposium

Document containing information on the three workshops to be held from 1:00 - 5:00 pm on February 6th, 2025.

2025 Sdsu Data Science Symposium Abstracts, South Dakota State University

SDSU Data Science Symposium

Abstracts for keynotes, invited sessions, and posters for the 2025 SDSU Data Symposium.

Comprehensive Sumo Proteomic Analyses Identify Hiv Latency-Associated Proteins In Microglia., Fergan Imbert, Dianne Langford

Rowan-Virtua School of Osteopathic Medicine Departmental Research

SUMOylation, the post-translational modification of proteins by small ubiquitin-like modifiers, plays a critical role in regulating various cellular processes, including innate immunity. This modification is essential for modulating immune responses and influencing signaling pathways that govern the activation and function of immune cells. Recent studies suggest that SUMOylation also contributes to the pathophysiology of central nervous system (CNS) viral infections, where it contributes to the host response and viral replication dynamics. Here, we explore the multifaceted role of SUMOylation in innate immune signaling and its implications for viral infections within the CNS. Notably, we present novel proteomic analyses aimed at …