Digital Commons Network^™

A Tale Of Diplomacy And Equity: India’S Strive Towards Covid-19 Vaccine Pricing And Procurement, Samrudh Kopparam

Journal of Law and Public Policy

No abstract provided.

Vaccine Crisis And Patent Rights—Issues And Challenges: A Global Perspective, Kshitij Kumar Rai, Sakshi Agarwal

Journal of Law and Public Policy

No abstract provided.

Kate Fields Full Interview Transcript, Urban Green Lab, Tennessee State University

Hear from Kate Fields - Native Nashvillian Feeding the Flocks

No abstract provided.

An Ontology-Based Rare Disease Common Data Model Harmonising International Registries, Fhir, And Phenopackets., Adam S L Graefe, Miriam R Hübner, Filip Rehburg, Steffen Sander, Sophie A I Klopfenstein, Samer Alkarkoukly, Ana Grönke, Annic Weyersberg, Daniel Danis, Jana Zschüntzsch, Elisabeth F Nyoungui, Susanna Wiegand, Peter Kühnen, Peter N Robinson, Oya Beyan, Sylvia Thun

Faculty Research 2025

Although rare diseases (RDs) affect over 260 million individuals worldwide, low data quality and scarcity challenge effective care and research. This work aims to harmonise the Common Data Set by European Rare Disease Registry Infrastructure, Health Level 7 Fast Healthcare Interoperability Base Resources, and the Global Alliance for Genomics and Health Phenopacket Schema into a novel rare disease common data model (RD-CDM), laying the foundation for developing international RD-CDMs aligned with these data standards. We developed a modular-based GitHub repository and documentation to account for flexibility, extensions and further development. Recommendations on the model's cardinalities are given, inviting further refinement …

Carboxymethyl Cellulose Assisted Reforming Of Poly Acrylic Acid Co Methyl Methacrylate Composite For Wastewater Treatment And Effective Hosting Of Antimicrobial Silver, Ahmed Mokhtar, Hassan Nageh, Salah Abdo Hassan, Mohamed Mekewi, Atef Samir Darwesh

Dentistry

Herein, novel polymer composite is fabricated by hybridizing poly (acrylic acid-co-methyl methacrylate) filaments with carboxymethyl cellulose, which efficiently reorients and strictly ties the fibrous chains to form polymeric units of plate-like morphology. This innovative hybrid polymer composite is analyzed using XRD, FT-IR, swelling and contact angle studies, DLS, AFM, and SEM. Removal efficiency of such polymer composite is scrutinized in colored wastewater treatment. Langmuir and pseudo-first-order kinetic models best describe safranine dye removal from wastewater, adopting exothermic adsorption progression with elevated capacity (~ 59.47 mg/g) and accelerated rate (~ 1.06 h− 1). Such polymer composite exhibits persistent removal efficiency of …

Exploring The Relationship Between Psychiatric Illness And Dermatological Disorders: A Narrative Review, Alan D. Kaye, Rahib K. Islam, Abigayle M. Castine, Grace C. Wester, William T. Barham, Catherine G. Nguyen, Elena Plakotaris, Bradley Dorius, Julian Kim, Patricia Griffin, Amber Edinoff, Sahar Shekoohi, Giustino Varrassi

School of Medicine Faculty Publications

The interplay between psychiatric conditions and dermatological disorders is complex and multifaceted, often resulting in significant challenges for both diagnosis and treatment. This narrative review examines associations between specific psychiatric conditions, trichotillomania, attention deficit hyperactivity disorder, schizophrenia, bipolar disorder, and various dermatological disorders. The present investigation delves into pathophysiological mechanisms, clinical presentations, and management strategies of these comorbid conditions. Psychiatric disorders can exacerbate dermatological conditions through mechanical trauma, medication side effects, and stress-induced exacerbations, while dermatological disorders can lead to significant psychiatric morbidity. The biopsychosocial approach, emphasizing the importance of integrated care involving dermatologists and mental health professionals, is crucial …

Quantitative Characterization And Prediction Of The Binding Determinants And Immune Escape Hotspots For Groups Of Broadly Neutralizing Antibodies Against Omicron Variants: Atomistic Modeling Of The Sars-Cov-2 Spike Complexes With Antibodies, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Nishank Raisinghani, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

A growing body of experimental and computational studies suggests that the cross-neutralization antibody activity against Omicron variants may be driven by the balance and tradeoff between multiple energetic factors and interaction contributions of the evolving escape hotspots involved in antigenic drift and convergent evolution. However, the dynamic and energetic details quantifying the balance and contribution of these factors, particularly the balancing nature of specific interactions formed by antibodies with epitope residues, remain largely uncharacterized. In this study, we performed molecular dynamics simulations, an ensemble-based deep mutational scanning of SARS-CoV-2 spike residues, and binding free energy computations for two distinct groups …

Legal Dimensions Of Rights Of Nature Applied In The Context Of The River Plym: River Plym Project Phase 1 Appendix, Jason Lowther

School of Law, Humanities and Social Sciences

This review of the literature and legal framing of so-called river rights – loosely understood by reference to the extension of certain characteristics or a particular status upon the river – has been collated in the context of the River Plym-citizenship advocacy project. It aims to examine the legal and policy potential for the attribution of ‘rights’ upon the River Plym. It does so by outlining the challenges facing the waterway, in common with many others, and noting the limitations of the current regulatory systems applied to it. The paper then offers a commentary of legal alternatives to the current …

Exploring The Connection Between Rna Splicing And Intellectual Disability, Anthony Caputo, Ashleigh E. Schaffer

Faculty Scholarship

Intellectual disability (ID) is a broad diagnostic category that encompasses individuals with impaired cognitive ability. While these disorders have heterogeneous causes, recent developments in next-generation sequencing (NGS) are revealing the prevalence of genetic etiologies. In particular, germline mutations in genes that affect RNA splicing are increasingly common causes of ID disorders. Research to elucidate the functional relationship between splicing and neurodevelopment is critical since molecular therapeutics require a nuanced understanding of the pathological mechanism. In this review, we first summarize the trends that have led to the discovery of the RNA splicing–ID relationship, then discuss recent progress and future directions …

The Development Of Optical Sensing Techniques As Digital Tools To Predict The Sensory Quality Of Red Meat: A Review, Georgios Anagnostou, Alessandro Ferragina, Emily C. Crofton, Jesus Maria Frias Celayeta, Ruth M. Hamill

Research Outputs: 2025-Present

No abstract provided.

Large Range Sizes Link Fast Life Histories With High Species Richness Across Wet Tropical Tree Floras, Timothy R. Baker, Stephen Adu-Bredu, Kofi Affum-Baffoe, Shin-Ichiro Aiba, Sophie Fauset, Perpetra Akite, Miguel Alexiades, Everton Almeida, Edmar Almeida De Oliveira, Esteban Alvarez Davila, Christian Amani, Ana Andrade, Luiz Aragao, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Peter Ashton, Suspense A. Averti Ifo, Gerardo A. C. Aymard, Michel Baisie, William Balee, Michael Balinga, Lindsay F. Banin, Olaf Banki, Christopher Baraloto, Jorcely Barroso, Hans Beeckman, Jean-Francois Bastin, Serge Begne, Natacha Nssi Bengone

School of Geography, Earth and Environmental Sciences

Understanding how the traits of lineages are related to diversification is key for elucidating the origin of variation in species richness. Here, we test whether traits are related to species richness among lineages of trees from all major biogeographical settings of the lowland wet tropics. We explore whether variation in mortality rate, breeding system and maximum diameter are related to species richness, either directly or via associations with range size, among 463 genera that contain wet tropical forest trees. For Amazonian genera, we also explore whether traits are related to species richness via variation among genera in mean species-level range …

Motor Pool Selectivity Of Neuromuscular Degeneration In Type I Spinal Muscular Atrophy Is Conserved Between Human And Mouse, Justin C Lee, Wendy K Chung, David J Pisapia, Christopher E Henderson

Faculty, Staff and Students Publications

Spinal muscular atrophy (SMA) is caused by low levels of the survival motor neuron (SMN) protein. Even though SMN is ubiquitously expressed, the disease selectively affects motor neurons, leading to progressive muscle weakness. Even among motor neurons, certain motor units appear more clinically resistant to SMA. To quantitatively survey selective resistance, we studied extensive neuromuscular autopsies of Type I SMA patients and age-matched controls. We found highly divergent degrees of degeneration of neighboring motor units, even within individual cranial nerves or a single anatomical area such as the neck. Examination of a Type I SMA patient maintained on life support …

The Catch Effort Of Spiny Lobster (Panulirus Argus) On South Caicos, British West Indies, Edward J. Burge Jr

The Geographical Bulletin

The spiny lobster, Panulirus argus, which inhabits bank around South Caicos, Turks and Caicos Islands, is the most economically important crustacean in the Caribbean region. In recent years concern regarding overfishing has become prominent. In this study 46 boat loads of specimens, with catches derived from 11 fishing sites were surveyed for data sets including size, sex, and amount from each site. The catch-per-unit effort calculated for each site revealed that individual diving ability and ease of harvest were the greatest determinants for choice of fishing site. Environmental conditions of spiny lobster habitats; such as, water depth and direction of …

Temporal And Spatial Changes In Beaver Pond Locations, Eastern Glacier National Park, Montana, U.S.A., Ross K. Meentemeyer, David R. Butler

The Geographical Bulletin

Sequential aerial photographs from 1966, 1973, 1984, and 1991 were used to map the number and distribution of beaver ponds in a portion of eastern Glacier National Park, Montana. The most stable ponds were located on deltaic environments. Ponds located on intermittent streams were somewhat less stable. A general equilibrium of pond number and site location exists in the study area throughoutthe 25-year period. This result contrasts with those from historical studies in eastern and central North America, where beaver populations at the turn of the century had probably been much lower than in Glacier National Park.

Probing The Stability Of Designed Protein, Axel Irianni, Shuvo Chakraborty, Maral Afshinpour

SDSU Data Science Symposium

Naturally occurring proteins have evolved to perform specific biochemical functions, and their amino acid sequences are optimized for those functions rather than for stability. Enhancing protein stability without compromising its function is highly desirable for biotechnological applications, such as vaccine design. Computational protein design algorithms offer a solution by making targeted amino acid changes to the native protein sequence, potentially enhancing stability without the need for the lengthy, labor-intensive, and costly experimental processes typically involved in stabilizing proteins. There are various categories of computational protein design algorithms, and it remains unclear which approach is the most effective. In this study, …

Filters For Forecasting Crop Health: Analyzing And Projecting The Temporal Evolution Of Landsat Ndvi Data Using Dynamic Linear Models And The Kalman Filter, Kamal Albousafi, Hossein Moradi, Jung-Han Kimn

SDSU Data Science Symposium

Accurately forecasting food availability is a critical task. One approach involves utilizing remote sensing data, such as satellite images, to observe the health of crop fields using different Vegetation Indices (VI). The Normalized Difference Vegetation Index (NDVI) provides a sound metric to track the “greenness” of crops over time. In this research, we develop statistical models that capture the dynamics of NDVI time series data to make better predictions of its future values. The median NDVI of the pixels of a farm located in Edmunds County, South Dakota, is obtained using imagery from the Landsat 5 and Landsat 8 satellites, …

Erau Admissions, Eric Wilson

ERAU SMART@ER Educators Conference

Admissions provides insightful information about the process of accepting and admitting students to ERAU as well as opportunities for students to apply for scholarships and awards.

Erau Admissions, Eric Wilson

ERAU SMART@ER Educators Conference

Admissions provides insightful information about the process of accepting and admitting students to ERAU as well as opportunities for students to apply for scholarships and awards. Session repeated on Friday at 10:00.

2025 Sdsu Data Science Symposium Abstracts, South Dakota State University

SDSU Data Science Symposium

Abstracts for keynotes, invited sessions, and posters for the 2025 SDSU Data Symposium.

The Application And Innovation Of Casgevy On Sickle Cell Disease, Emily Tackett, Le Thien Truc Pham, Hannah Salamie, Arin Wade, Allison Provenzale, Alexander Defranco, Ashley Jacob, Brianna Lu, Joshua Honaker, Amy Stockert

Pharmacy and Wellness Review

Casgevy, sickle cell anemia, SCA, sickle cell disease, SCD, CRISPR/Cas9, hydroxyurea, hemoglobin, Hb, l-glutamine, voxelotor, Crizanlizumab, Lyfgenia, stem cells, genetics, pharmacogenetics, pharmacogenomics

Epr Imaging Workshop: From Theory And Practice To Applications, Arthur H. Heiss, Ralph T. Weber, Sandra S. Eaton, Gareth R. Eaton

TeachEPR Submissions

Methods of imaging and insights from imaging are described. Practical aspects of sample type and dimensions are described.

Workshop presented at the 27th International EPR Symposium, sponsored by Bruker BioSpin EPR Division and the University of Denver, in Denver, Colorado on August 1, 2004.

The Beacon, February 7, 2025, Beacon Staff

The Beacon, 2024-2025

Unsung Hero: Dr. Doug Anderson; County coffee shop showdown; Flipturn's album highlights vocal range; "Mufasa" deemed a crime against the original; Senior spotlight: double major Elliana Zerr; Dr. Bates leads youth program launch in Kenya; Beacon staff highlights and changes; Local brews and fresh reviews; Practical benefits of studying abroad; Archives hero at NW; The greatest romance story; Living a monastic life; The big game: Predictions from NW staff; Softball off to a great start to 2025 season; Students enjoy winter intramurals at NW; DeepSeek: a new AI competitor; Orange City to host RAGBRAI;

Cis-Regulation And Evolution Of Genes Involved In Immunity, Changxu Fan

Arts & Sciences Electronic Theses and Dissertations

The mammalian genome contains ~20,000 genes. Some of these genes are essential for the cellular processes of most, if not all, cells, and are therefore expressed across a variety of cell types. Other genes, however, are involved in specialized processes such as defense against pathogens. These immunity-related genes are often only expressed in immune cells that require them to function. My dissertation addresses how the expression of immunity-related genes is regulated, with the rationale that such knowledge will inform the development of therapies to turn on/off immune genes, as a way of activating/inhibiting the effector functions of immune cells, which …

Workshop On The Epr Of Aqueous Samples, Gareth R. Eaton

TeachEPR Submissions

The problem with water and other materials that absorb microwave energy are described. Dielectric properties are described as a function of frequency.

Workshop presented at the 25th International EPR Symposium on July 28, 2002.

Design And Application Of Molecularly Imprinted Polymers For The Detection Of Bpa, Pfoa, And Caffeine, Finbarr Buckley

Theses

Molecular Imprinted Polymers (MIPs) are polymer based solid phase extraction (SPE)recognition systems. MIPs were formulated using Acrylic Acid (AA) and Ethylene glycoldimethacrylate (EGDMA) to selectively target the following compounds Bisphenol A (BPA),Perfluorooctanoic acid (PFOA) and caffeine. This study presents novel MIPs for each targetqualitatively analysed with Raman Spectroscopy with Surface Enhanced Raman Spectroscopy(SERS) substrates. SERS can greatly enhance Raman signals allowing for detection of lowconcentration solutions. BPA, a possible carcinogen and hormone disruptor, is a very commonreagent in manufacturing as is known to leech into environmental and consumer products.PFOA, a constituent of polyfluoroalkyl substances (PFAS), can cause kidney and thyroiddisease, …

Evaluating Maternal Drug Use Disparities, Risk Factors And Outcomes In Northeast Arkansas: A Pre, During, And Post-Covid-19 Pandemic Analysis., Enrique Gomez Pomar, Johnna Berryhill, Sudeepa Bhattacharyya

Pediatrics Faculty Publications

INTRODUCTION: The use of addictive substances remains a major health problem in the U.S. An increase in drug overdose and mortality was observed during the COVID-19 pandemic, especially in underserved populations. This surge also impacted pregnant women especially with the use of marijuana (THC) and opioids.

METHODS: Retrospective study analyzing mother-infant dyads with reported Meconium Drug Screen (MDS) results, from January 2018 through April 2023 at a reference hospital serving an urban and rural area of Arkansas. Due to the absence of universal screening, the prevalence of drug use was variable during the study period. An adjusted monthly positive rate …

2025-02-07 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of February 7, 2025, which includes the meeting minutes of the meeting held on November 15, 2024.

The Ai-Robotic Prescription: Legal Liability When An Autonomous Ai Robot Is Your Medical Provider, Erika Sophia Grossbard

University of Miami Business Law Review

As AI-driven healthcare accelerates, lawmakers must race against time to establish vital regulations, striving to protect patient safety in an era of increasingly autonomous medical devices. The real challenges arise when an automated AI medical device harms a patient during medical care, and the law has yet to clarify how liability should be allocated among its stakeholders. Currently, semi-autonomous robots are diagnosing medical conditions and performing surgeries. Eventually, autonomous AI medical providers will enter the market, capable of making independent medical decisions and providing treatment. These autonomous robots will function more like medical practitioners rather than merely as assistive tools …

Electro-Oxidative Deoxyfluorination Of Arenes With Net3·3hf, En Chih Liu, Sabrina M. Reich, Mayank Tanwar, Matthew Neurock, Long Luo, Melanie S. Sanford

Chemistry Faculty Research & Creative Works

This report describes the design, development, and optimization of an electrochemical deoxyfluorination of arenes using a tetrafluoropyridine-derived leaving group. NEt₃·3HF serves as the fluoride source, and the reactions are conducted using either constant potential or constant current electrolysis in an undivided electrochemical cell. Mechanistic studies support a net oxidative pathway, in which initial single-electron oxidation generates a radical cation intermediate that is trapped by fluoride. The resulting radical undergoes a second oxidation reaction, followed by the loss of the leaving group to yield the fluoroarene product.

The Ethical Governance Of Artificial Intelligence: Using The Ai Integrative Risk-Based (Airb) Model To Achieve Compliance Risk Management, Miriam Weismann

University of Miami Business Law Review

While undeniably powerful, artificial intelligence algorithms also pose significant risks. The ethical, legal, social, and scientific implications of various AI models can be profound, as demonstrated by the subprime mortgage crisis. This crisis, worsened by the unregulated use of derivative algorithms, is a stark reminder of the pivotal role of individual accountability, ethical responsibility, and regulation in preventing future “catastrophic harm.”1 This Article ventures into the uncharted territory of AI ethical governance and aims to advance AI scholarship and address the unresolved issue of ethical compliance management in AI. Employing a risk-based assessment tool is critical for developing regulatory and …