Digital Commons Network^™

The Mutational Landscape And Functional Effects Of Noncoding Ultraconserved Elements In Human Cancers, Recep Bayraktar, Yitao Tang, Mihnea P Dragomir, Cristina Ivan, Xinxin Peng, Linda Fabris, Jianhua Zhang, Alessandro Carugo, Serena Aneli, Jintan Liu, Mei-Ju M Chen, Sanjana Srinivasan, Iman Sahnoune, Emine Bayraktar, Kadir C Akdemir, Meng Chen, Pranav Narayanan, Wilson Huang, Leonie Florence Ott, Agda Karina Eterovic, Oscar Eduardo Villarreal, Mohammad Moustaf Mohammad, Michael D Peoples, Danielle M Walsh, Jon Andrew Hernandez, Margaret B Morgan, Kenna R Shaw, Jennifer S Davis, David Menter, Constantine S Tam, Paul Yeh, Sarah-Jane Dawson, Laura Z Rassenti, Thomas J Kipps, Tanja Kunej, Zeev Estrov, Simon A Joosse, Luca Pagani, Catherine Alix-Panabières, Klaus Pantel, Alessandra Ferajoli, Andrew Futreal, Ignacio I Wistuba, Milan Radovich, Scott Kopetz, Michael J Keating, Giulio F Draetta, John S Mattick, Han Liang, George A Calin

Faculty, Staff and Student Publications

The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNAs (ncUCEs), and their functional relevance in cancers remain poorly characterized. Here, we perform a systematic analysis of whole-genome and in-house targeted UCE sequencing datasets from more than 3000 patients with cancer of 13,736 UCEs and demonstrate that ncUCE somatic alterations are common. Using a multiplexed CRISPR knockout screen in colorectal cancer cells, we show that the loss of several altered ncUCEs significantly affects cell proliferation. In-depth functional studies in vitro and in vivo further reveal that specific ncUCEs can be enhancers of tumor suppressors (such as ARID1B) …

The Bacterial Microbiome Modulates The Initiation Of Brain Metastasis By Impacting The Gut-To-Brain Axis, Matteo Massara, Michelle Ballabio, Bastien Dolfi, Golnaz Morad, Vladimir Wischnewski, Eleni Lamprou, Joao Lourenco, Stéphanie Claudinot, Hector Gallart-Ayala, Rui Santalla Méndez, Annamaria Kauzlaric, Nadine Fournier, Ashish V Damania, Matthew C Wong, Julijana Ivanisevic, Nadim J Ajami, Jennifer A Wargo, Johanna A Joyce

Faculty, Staff and Student Publications

Brain metastases (BrMs) are the most common brain tumors in patients and are associated with poor prognosis. Investigating the systemic and environmental factors regulating BrM biology represents an important strategy to develop effective treatments. Toward this goal, we explored the contribution of the gut microbiome to BrM development by using in vivo breast-BrM models under germ-free conditions or antibiotic treatment. This revealed a detrimental role of gut microbiota in fostering BrM initiation. We thus evaluated the impact of antibiotics and BrM outgrowth on the gut-brain axis. We found the bacterial genus Alistipes was differentially present under antibiotic treatment and BrM …

Hurricane Irma's Impact On Mortality Among The Chronically Ill Populations In Florida, Cody Ray Thornton

Walden Dissertations and Doctoral Studies

Natural disasters pose significant risks to individuals with chronic diseases, exacerbating health disparities through disruptions in healthcare access and systemic vulnerabilities. This study investigated the association between chronic disease-related mortality occurring within 2 months of Hurricane Irma, and whether demographic variables, including age, sex, race, Hispanic ethnicity, poverty, urbanicity, and educational attainment, modified this relationship. This cross-sectional study used the social-ecological model to analyze secondary mortality data from the National Vital Statistics System. Bivariate and multivariate logistic regression revealed that deaths from chronic illnesses, occurring between September 2017 and October 2017, were 2.694 times higher, compared to the same period …

Immune Checkpoint Inhibitors Plus Debulking Surgery For Patients With Metastatic Renal Cell Carcinoma: Clinical Outcomes And Immunological Correlates Of A Prospective Pilot Trial, Sangeeta Goswami, Jianjun Gao, Sreyashi Basu, Daniel D Shapiro, Jose A Karam, Rebecca Slack Tidwell, Kamran Ahrar, Matthew T Campbell, Yu Shen, Alexandro E Trevino, Aaron T Mayer, Alexsandra B Espejo, Christian Seua, Marc D Macaluso, Yulong Chen, Wenbin Liu, Zhong He, Shalini S Yadav, Ying Wang, Priya Rao, Li Zhao, Jianhua Zhang, Sonali Jindal, Nizar M Tannir, Andrew Futreal, Linghua Wang, Padmanee Sharma

Faculty, Staff and Student Publications

Surgical removal of primary tumors reverses tumor-mediated immune suppression in pre-clinical models with metastatic disease. However, how cytoreductive surgery in the metastatic setting modulates the immune responses in patients, especially in the context of immune checkpoint therapy (ICT), is not understood. We report the first prospective, pilot, non-comparative clinical trial (NCT02210117) to evaluate the feasibility, clinical benefits, and immunologic changes of combining three different ICT-containing strategies with cytoreductive surgery or biopsy for patients with metastatic clear cell renal cell carcinoma. Primary safety endpoint of this trial has been met, with 43 patients completing cytoreductive surgery, 36 patients undergoing …

Pharmacological Interventions For Negative Symptoms In Schizophrenia: A Systematic Review Of Randomised Control Trials, Lorenzo Moccia, Francesca Bardi, Maria Benedetta Anesini, Sara Barbonetti, Georgios D Kotzalidis, Sara Rossi, Romina Caso, Flavia Grisoni, Giuseppe Mandracchia, Stella Margoni, Tommaso Callovini, Delfina Janiri, Marianna Mazza, Alessio Simonetti, Silvia Montanari, Gianna Autullo, Giovanni Camardese, Maria Pepe, Marco Di Nicola, Vassilij Di Giorgio, Fabio Conti, Gabriele Sani, On Behalf Of The Gemelli Repsy Study Group

Faculty, Staff and Students Publications

Background/Objectives: While positive symptoms of schizophrenia are often satisfactorily controlled, negative symptoms are difficult to treat, persisting despite treatment. Different strategies have been devised to deal with this problem. We aimed to review drug treatment for negative symptoms of schizophrenia in controlled trials of marketed drugs.

Methods: We searched the PubMed database and the resulting records' reference lists to identify eligible trials using schizophrenia[ti] AND "negative symptom*"[ti] as a search strategy. We determined eligibility through Delphi rounds among all authors.

Results: On 11 February 2025, we identified 1485 records on PubMed and 3 more from reference lists. Eligible were 95 …

Progression Of Otologic And Nasal Symptoms In Primary Ciliary Dyskinesia Throughout Childhood, Isabelle Dagher, Adam J Kimple, Thomas W Ferkol, Scott D Sagel, Sharon D Dell, Carlos E Milla, Lang Li, Feng-Chang Lin, Kelli M Sullivan, Maimoona A Zariwala, Michael R Knowles, Margaret Rosenfeld, Margaret W Leigh, Stephanie D Davis, Genetic Disorders Of Mucociliary Clearance Consortium

2020-Current year OA Pubs

OBJECTIVE: Primary ciliary dyskinesia (PCD) is characterized by upper and lower airway disease. Multiple studies have demonstrated the progression of pulmonary disease; however, longitudinal changes in the otologic and nasal symptoms have not been well described in patients. This study defines age-related prevalence, age of onset, and age-related trends in self-reported otologic and sinonasal comorbidities in individuals with PCD.

STUDY DESIGN: A prospective, longitudinal, multicenter, observational study spanning up to 12 years.

SETTING: Six PCD centers in North America.

METHODS: Inclusion criteria were < 19 years of age and a confirmed diagnosis of PCD based on electron microscopy and/or genetics. A standardized medical history questionnaire and physical exam were completed during each study visit. Descriptive statistics were performed for the entire cohort as well as for subgroups based on ciliary ultrastructure.

RESULTS: A total of 147 participants were followed for an average of 7.6 ± 3.2 years. Pressure …

Characterization Of Rationally Designed Crispr/Cas9-Based Dna Methyltransferases With Distinct Methyltransferase And Gene Silencing Activities In Human Cell Lines And Primary Human T Cells, Rosa Selenia Guerra-Resendez, Samantha Legoff Lydon, Alex J Ma, Guy C Bedford, Daniel R Reed, Sunghwan Kim, Erik R Terán, Tomoki Nishiguchi, Mario Escobar, Andrew R Dinardo, Isaac B Hilton

Faculty, Staff and Students Publications

Nuclease-deactivated Cas (dCas) proteins can be used to recruit epigenetic effectors, and this class of epigenetic editing technologies has revolutionized the ability to synthetically control the mammalian epigenome and transcriptome. DNA methylation is one of the most important and well-characterized epigenetic modifications in mammals, and while many different forms of dCas-based DNA methyltransferases (dCas-DNMTs) have been developed for programmable DNA methylation, these tools are frequently poorly tolerated and/or lowly expressed in mammalian cell types. Further, the use of dCas-DNMTs has largely been restricted to cell lines, which limits mechanistic insights in karyotypically normal contexts and hampers translational utility in the …

Invasion And Metastasis In Cancer: Molecular Insights And Therapeutic Targets, Yongxing Li, Fengshuo Liu, Qingjin Cai, Lijun Deng, Qin Ouyang, Xiang H-F Zhang, Ji Zheng

Faculty, Staff and Students Publications

The progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting their quality of life and survival rates. Research efforts have consistently focused on the intricate mechanisms underlying this process and the corresponding clinical management strategies. Consequently, a comprehensive understanding of the biological foundations of tumor metastasis, identification of pivotal signaling pathways, and systematic evaluation of existing and emerging therapeutic strategies are paramount to enhancing the overall diagnostic and treatment capabilities for metastatic tumors. However, current research is …

Overview Of Chromatographic Methods Of Analysis Of Penicillins In Food Matrices Of Animal Origin, Tarekegn Tadesse Unade, Gudeta Duga Geresu, Pawar A. Krishnamanjari

International Journal of Health and Allied Sciences

Penicillins are β-lactam antibiotics indicated for preventing and treating diseases in veterinary medical practice. Improper use of these antibiotics in animals may result in residues in foodstuffs such as milk, egg, and meat, which can cause unwanted effects like allergy, and development of bacterial resistance. So, it is important to regulate the use of penicillins in foodstuffs of animal origin. Regulatory bodies in different countries established maximum residue levels to be allowed in food matrices. To address the regulatory requirements, food matrices need to be investigated with proper methods of analysis. Several analytical methods were developed and validated to determine …

Exploring The Therapeutic Potential Of Barbaloin: A Wonder Constituent From Aloe Vera Plant, Akanksha Andhare, Kranti Satpute, Shoaeb Mohammad Syed

International Journal of Health and Allied Sciences

The aim of current study was to explore chemistry and therapeutic potential of barbaloin. A detailed literature review was carried out at various data bases such as PubMed, Elsevier, Springer, Wiley, Taylor & Francis, etc. The healing plant aloe emodin's main compound is barbaloin (C21H22O9), anthrone's C-glucoside. The Liliace family includes perennial succulent aloe vera. Barbaloin, a pale-yellow aloe vera powder, is a first-group glucoside of the alove emodin anthrone molecule. Barbaloin has anti-inflammatory, cathartic, antiviral, antibacterial, and antioxidant qualities that prevent cancer. Barbaloin also improves cardiovascular health, test perception, enzyme metabolism, and bioavailability. Barbaloin may help treat eczema, psoriasis, …

Exploring The Relationship Between Social Context Of Speech In Race, Gender And Autonomic Detection Of Hate Speech On Social Media, Tilak Chaturvedi, Sangeetha S R, Patteswari Duraisamy

International Journal of Health and Allied Sciences

This review studies the development on the work done on the effects of social context factors of race and gender on the automated detection of hate speech found in social media from the period of 2013 to 2023. The review initially discussed the variables of social media and social context of speech and then discussed the literature produced on the effects of race and gender on social media, hate speech and social media research, the work done on automated detection of online hate speech and then the effect of race and gender in hate speech detection. The review found that …

Nanomaterials To Transform Infection Control With Antimicrobial Solutions, Ravikumara Moodalakoppalu Yogarajachari, Charan Kumar Kachintaya, Lingaraju Honnuru Gurusiddappa, Gururaj Kudur Jayaprakash, Shankramma Kalikeri

International Journal of Health and Allied Sciences

Antimicrobial resistance (AMR) is a major global health problem. The growing number of antibiotic-resistant microbes needs the development of novel antibiotics. Nanotechnology shows potential for overcoming bacterial resistance. Nanoparticles, particularly those around 100 nm, display higher antibacterial activity by using methods that differ from traditional antibiotics. When particle size reduces, materials such as zinc and silver improve their antibacterial action. There are several techniques to evaluate nanoparticle antibacterial activity, each having merits and downsides. This study critically evaluates selected literature, identifies bactericidal mechanisms, and discusses assessment procedures, emphasizing the importance of innovative approaches to bacterial infections.

Synthesis Of Corrosion Inhibitors Based On (Thio)Urea, Orthophosphoric Acid And Formaldehyde And Their Inhibition Efficiency, Abror Nomozov, Khasan Beknazarov, Sakhomiddin Khodjamkulov, Zafar Misirov, Sarvinoz Yuldashova

Baghdad Science Journal

In this article, the optimal conditions for the synthesis of two types of oligomeric corrosion inhibitors, polymethylene diamidophosphate (PDAF-1) and polymethylene thiodiamidophosphate (PTAF-2), based on compounds such as thiourea, urea, and orthophosphoric acid containing nitrogen and phosphorus, as well as their formulas, are determined. At first, (thio)diamidophosphate - PDAF-1 brand corrosion inhibitor was synthesized using urea and orthophosphoric acid in a 2:1 mol ratio at a temperature of 135–140°C. The second type of polymethylene thiodiamidophosphate (PTAF-2) corrosion inhibitor was synthesized based on the process of condensation in an aqueous environment at a temperature of 60°C, by adding formaldehyde to this …

Synthesis, Diagnosis As Well As Biological Activity Studies Of Some Metal Ion Complexes Of Schiff Bases Derived From 4-Aminoantipyrine, Amera F. Mohammed, Israa A. Saeed, Khansaa Sh. Al-Nama

Baghdad Science Journal

Polydintate Schi base ligands L1 = orthohydroxy aniline, 4-aminoantipyrin-(N,N¯ benzilidene) and L2 = 5-Chloro- 2-hydroxyaniline,4-aminoantipyrine-(N,N¯) benzilide obtained from condensation of benzil and 4-aminoantipyrine with 2-aminophenol or 2-amino 4-chlorophenol in (1:1:1) molar ratio for each component. Ligands employed to synthesis complexes in the general molecular formula [ML1Cl]Cl and [ML2]Cl2 respectively; M=Mn(II), Co(II), Ni(II) and Zn(II). To diagnose the ligands and the complexes the following techniques were adopted: UV-Visible FTIR and 1H-NMR spectroscopies, micro elemental analyses of metal ions and carbon, hydrogen and nitrogen, molar conductivity and magnetic susceptibility. Measurements obtained from the conductivity which was done with DMSO solution indicated that …

Modification And Study Biological Activity Of Chitosan With Compounds Containing Azo Group, Ruwaidah S. Saeed, Huda A. Hassan, Muna S. Al-Rawi

Baghdad Science Journal

In the present research synthesis and study of biological activity a series of new polymers modified of chitosan with compounds containing azo group. Beginning diazonium salt produced from 3,30-dimethyl-[1,10-biphenyl]-4,40-diamine reacted with concentrated HCl acid and sodium nitrite. The coupling reaction between diazonium salt with substituted aromatic aldehyde to produce Azo derivatives (1-6). Azo Schi bases Chitosan (7-12) were synthesized by condensation of Chitosan with Azo derivatives (1-6) in ethanol with some drops of glacial acetic acid. The structural modifications of Chitosan ring (linked to a bioactive azo moiety) were expected to give new derivatives (7-12) with a diverse range of …

Synthesis Of Some New Hydrazide-Hydrazone And Heterocyclic Compounds Thiophene, Imine, Coumarin And Pyrazole Derivatives, Istabrick M. Al-Mola, Ammar H. Al-Sabawi

Baghdad Science Journal

A series of new thiophene, imine, coumarin and pyrazole derivatives X4-X16 were synthesized from N-(1-(4- (benzylsulfonyl)phenyl)ethylidene)-2-cyanoacetohydrazide X3 as a starting material with di erent reagents (tetralone, cyclopentanone, cycloheptanone, 2-hydroybenzaldehyde, 2-hydroxy-1-naphthaldehyde, CS2 and phenylisothiocyanate). The compound X3 was synthesized by the reaction of 4-(benzylsulfonyl)acetophenone with 2-cyanoacetohydrazide under reflux in ethanol. The structures of all synthesized compounds were confirmed by (FT-IR, 1H-NMR, and 13C-NMR).

Liquid Phase Extraction And Determination Of Chromium (Iii) Ion In Aqueous Solution Using Dithiocarbamate Derivative Reagent, Ivan Malik Shaker, Ahmed Fadhil Khudhair, Hayder Hamied Mihsen

Baghdad Science Journal

The new reagent N-methyl-N-((((4-bromophenyl)diazenyl)thio) carbonothioyl) aniline was made by the reaction of (sodium N-methyl-N-phenyldithiocarbamate)with 4-bromobenzenediazoniume salts. UV-Visible spectroscopy, elemental analysis, Fourier-transform infrared spectroscopy, mass spectroscopy, proton nuclear magnetic resonance spectroscopy, carbon-13 nuclear magnetic resonance spectroscopy, magnetic susceptibility measurements, and conductivity measurements to characterize the prepared compound. Using analytical and spectroscopic data, stoichiometry was calculated, and it was discovered that the complex was 1:2 (metal: ligand). The complexes’ molar conductivity was measured using dimethyl formide, and the results indicated that the produced complex was ionic. Results of elemental analysis and spectrum studies indicate that the compound has a tetrahedral structure. Cloud …

Synthesis, Antibacterial, Molecular Docking, And Ademt Studies Of New Mannich Bases Of Curcumin, Athra G. Sager, Jawad Kadhim Abaies, Ammar Ferman Abbood

Baghdad Science Journal

This study introduces an innovative approach employing N-(3-benzylureido)(methyl)-2-(6-methoxynaphthalen-2-yl)propanamide (J10) as an additive for recycled polyethylene terephthalate (PET) to produce thin film (J10-PET thin film), with a focus on their application in the removal of methylene blue (MB) and methyl orange (MO) from aqueous solutions. The study is primarily focused on unraveling the kinetics and equilibrium behaviors governing the removal of MB and MO. The investigation includes the determination of the equilibrium adsorption capacities (Q_e) of MB and MO at different temperatures (308, 323, and 333 K) and concentrations (5, 10, and 15 mg/g). Remarkably, the pseudo-second-order model is …

Green Innovation In Environmental Remediation: J10-Pet Thin Films For Efficient Removal Of Methylene Blue And Methyl Orange Contaminants, Jihan A. Mustafa, Parween H. Saleem, Huda A. Basheer

Baghdad Science Journal

This study introduces an innovative approach employing N-(3-benzylureido)(methyl)-2-(6-methoxynaphthalen-2-yl)propanamide (J10) as an additive for recycled polyethylene terephthalate (PET) to produce thin film (J10-PET thin film), with a focus on their application in the removal of methylene blue (MB) and methyl orange (MO) from aqueous solutions. The study is primarily focused on unraveling the kinetics and equilibrium behaviors governing the removal of MB and MO. The investigation includes the determination of the equilibrium adsorption capacities (Q_e) of MB and MO at different temperatures (308, 323, and 333 K) and concentrations (5, 10, and 15 mg/g). Remarkably, the pseudo-second-order model is …

Palladium (Ii) Mixed Ligand Complexes Of Benzoisothiazol-3(2h)-Dithiocarbamate (Bit-Dtc) And Tertiary Diphosphines: Synthesis, Characterization, Biological And Anticancer Studies, Nazk Mohammed Aziz

Baghdad Science Journal

[Pd(bit-dtc)₂] complex was prepared by the reaction of sodium benzoisothiazol-3(2H)-dithiocarbamate (Nabit-dtc) with sodium tetrachloropalladate(II). Treatment of [Pd(bit-dtc)₂] with one mole equivalent of Ph₂P(CH)_nPPh₂ afforded complexes of the type [Pd(bit-dtc)₂(Ph₂(CH₂)_n PPh₂)] in good yield: n = 1(dppm); n = 2 (dppe), n = 3 (dppp); n = 4 (dppb); n = (C₅H₄)₂Fe (dppf). The prepared complexes were characterized by elemental analysis, I.R., ¹H-{³¹P} and ³¹P-{¹H} NMR spectroscopy the dithiocarbamate …

Synthesis And Characterization Of New Acrylamide Derivatives And Studying Their Antibacterial Activity, Ruaa M. Dhedan, Sana H. Awaad, Suha. N. Fadhl

Baghdad Science Journal

This study aims to test the new derivatives of polymers on the biological activities of two types of bacteria work describes the synthesis of 1,3-oxazepine and self-polymerization via a cycloaddition reaction between Schiff's bases 2-methyl-N-(5-(2-methylbutanoylimino) pentylidene)but-2-enamide and succinic, maleic anhydride. The synthesized compounds were characterized by melting points, softening points, and physical properties such as swelling capacity, TGA, and FT-IR. The biological activity showed intermediate results against two bacterial isolates resistant to antibiotics.

Building Education System Resilience In Samoa: Exploring Systems, Policies And Classroom Practices, Yung Nietschke, Anna Dabrowski, Nora Warren, Michelle Arasi-Mulitalo

International Education Research

This report presents the findings of research on education system resilience in Samoa during and immediately following the COVID-19 pandemic in order to build a deeper understanding of policies and practices in place, and what lessons can be drawn to support system-wide adjustments to mitigate future school disruptions. Data included case studies of practice, student assessment data and secondary data analysis of the 2018-2021 PILNA surveys for Samoa. The study identified the policies and practices that contribute to the Samoan education system's capacity to respond and recover from crisis and the factors that can drive system resilience, including social, human …

09. Recursion Method, Gerhard Müller

Nonequilibrium Statistical Physics (2025)

Part nine of course materials for Nonequilibrium Statistical Physics (Physics 626), taught by Gerhard Müller at the University of Rhode Island. The available PDF includes both the lecture notes, additional materials, and exercises without solutions.

Gardner-Webb University Hosts Selah Week, A Time For Reflection And Renewal, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb University invites students, faculty, staff, and the surrounding community to participate in Selah Week, happening Feb. 24-28, a time dedicated to spiritual renewal and reflection. Themed “Encountering God,” this event will feature engaging worship services, student and faculty testimonies, and messages designed to inspire personal faith journeys.

The Current - Volume 35 Issue 9, Nova Southeastern University

Student Newspapers

No abstract provided.

Evaluation Of Physical And Chemical Condition Of A Group Of Waterloggedarchaeological Woods From The Yenikapı 16 Shipwreck, Sedef Hetto, Namik Kiliç, Asli Gökçe Kiliç

Turkish Journal of Earth Sciences

This study examined the physical and chemical condition of waterlogged archaeological wood (WAW) samples from the Yenikapı 16 shipwreck of plane (Platanus L.), elm (Ulmus L.), pine (Pinus L.), and fir (Abies L.), representing species with different wood properties. The maximum water content (MWC) and basic density (BD) values of 74 WAW samples from the shipwreck were calculated, and 7 of 74 samples were selected for analysis using scanning electron microscopy (SEM), X-ray fluorescence (XRF), and Fourier transform infrared spectroscopy (FTIR). The availability of samples, appropriate size, the species of the wood, and the wood’s degradation were all considered. The …

Environmental And Cultural Impacts Of The 8.2 Ka Event In Yenikapı (İstanbul/Türkiye), Ayşi̇n Konak, M. Namik Yalçin

Turkish Journal of Earth Sciences

The Neolithic lifestyle, which began in the 12th millennium BP with the emergence of villages in the core region extendingfrom Iran to central and southeastern Anatolia and Syria, began to spread to neighboring geographies, such as the Marmara region,in the 9th millennium BP. During the 8.2 ka event that occurred between 8300 and 7900 BP, cold and dry conditions prevailed in thenorthern hemisphere. During the winter months, the humidity decreased and cooling of about 6 ± 2 °C was observed. In order totest whether the 8.2 ka event was also effective in the İstanbul region, a set of inorganic geochemical …

Spectator 2025-02-20, Editors Of The Spectator

The Spectator

No abstract provided.

Self-Thickening Materials Derived From Phenylpropanoid Ene Reactions, Atanu Biswas, Huai N. Cheng, Bret Chisholm, Ryan Beni, Zengshe Liu, Karl Vermillion, Michael Appell, Kelton Forson, Omar El Seoud, Carlucio R. Alves, Roselayne F. Furtado

Chemistry Faculty Research

In this work, we report the observation of uncatalyzed ene reactions between several phenylpropanoid compounds and diethyl azodicarboxylate (DEAD). For allylbenzene, the reaction produces the ene product at molar ratios of up to 1:2 of allylbenzene to DEAD. At higher levels of DEAD, more complex reactions are observed. For the reaction between methyl eugenol and DEAD, similar ene reaction products have been found. However, the reaction of eugenol with DEAD is more complex; in addition to the ene reaction, other reactions happen at the same time. Most of the structures of the resulting products have been elucidated using NMR spectroscopy …

Ancient Mitogenomes Reveal Population Interactions With High Maternal Genetic Diversity In The Central Plains Of China During The Late Neolithic Period, Xiyan Wu, Linyi Nie, Canshuo Zhong, Lin Wang, Rongpeng Jin, Jinteng Liang, Pengxiang Liu, Fan Yang, Ke Chen, Tao Han, Baoxu Ding, Yonggan Fu

Human Biology Open Access Pre-Prints

The Central Plains of China is one of the earliest domestication hubs for broomcorn and foxtail millet. This region nurtured rich archaeological cultures and experienced extensive interactions with neighboring populations during the Neolithic period. However, limited genomic research has hindered a clear understanding of the maternal genetic structure and population expansion history in this era. Here, we report 12 complete mitochondrial genomes from individuals of the Yanzhai site population from Henan province of China during the Longshan Culture period, revealing a high level of maternal genetic diversity. The close genetic distance between these individuals and those of ancient populations from …