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2025

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Reponse Du Paturage Naturel A La Fertilization Azotee Sur Sol Basaltique En Adamaqua Camerounais, E Pamo, S Yonkeu Mar 2025

Reponse Du Paturage Naturel A La Fertilization Azotee Sur Sol Basaltique En Adamaqua Camerounais, E Pamo, S Yonkeu

IGC Proceedings (1977-2023)

Les paturages demeurent et demeureront encore pendant longtemps la principale source d'alimentation des ruminants en Afrique. Cependant, au Cameroun en general et dans le plateau de l'Adamaoua, berceau de l'elevage en particulier, la baisse de leur production inquiete de plus en plus les pastoralistes. Aussi s'avere-t-il necessaire de trouver Jes moyens permettant de ren­verser cette tendance et d'ameliorer cette situation. S'il est certain que des etudes (Yonkeu et al. 1985; Yonkeu et al., 1986; Pamo et al., 1989) ont ete menees sur la reponse des fourrages cultives a la fertilisation dans l'Adamaoua, tres peu de travaux a ce jour ont …


Some Nitrogen Forms And Micronutrients In Silage Maize Leaves As Affected By Nk Fertilization And Liming, C.L F. Carranca, M A. Castelo Branco Mar 2025

Some Nitrogen Forms And Micronutrients In Silage Maize Leaves As Affected By Nk Fertilization And Liming, C.L F. Carranca, M A. Castelo Branco

IGC Proceedings (1977-2023)

The nutritive value of a forage depends on the quality which, in time, is dependent on protein, sugar, cellulose, fat and min­eral elements content. The existence of deficiencies may limit the maximum yield and also the quality. Several experiments have been carried out in order to study the effect of liming and NK fertilization on the nutrients uptake by silage maize and yields.


The Diagnosis Of Grassland Mineral Nutrient Status Through Herbage Analysis, J Salette, Lydie Huche Mar 2025

The Diagnosis Of Grassland Mineral Nutrient Status Through Herbage Analysis, J Salette, Lydie Huche

IGC Proceedings (1977-2023)

It appears more and more clearly that soil analysis is not sufficient to give a good approximation of the mineral status of grassland soils. In perennial crops leaf analysis and empirical critical levels are widely utilized. This grassland approach emphasizes the good results which can be obtained for nitro­gen, potassium, phosphorus not from leaf but from the whole herbage plant analysis. This paper deals with pure grass stands.


Modelling Nutrient Uptake By A Grass Sward: Long Term Studies Over Several Years, J Salette, Lydie Huche Mar 2025

Modelling Nutrient Uptake By A Grass Sward: Long Term Studies Over Several Years, J Salette, Lydie Huche

IGC Proceedings (1977-2023)

Many experiments were conducted to assess the short term effects of fertilization management on nitrogen and mineral uptake of cut or grazed swards. One important work was performed to model the grass nutrition status during a regrowth (Salette, 1982; Salette et al., 1983; Salette et al., 1989), but for both a theoretical and practical point of view it is of great interest to evaluate the evolution of N and mineral uptake throughout all the years of a pasture life. This paper gives an analysis of nitrogen and mineral uptake dynamics during sev­eral years and proposes a model for sward N …


Modelling Nitrogen And Mineral Nutrient Uptake By A Grass Sward: Short Term Studies During The Sward Growth, J Salette, Lydie Huche, G Lemaire Mar 2025

Modelling Nitrogen And Mineral Nutrient Uptake By A Grass Sward: Short Term Studies During The Sward Growth, J Salette, Lydie Huche, G Lemaire

IGC Proceedings (1977-2023)

In a previous work, the evolution of nitrogen and mineral content during the grass regrowth between two successive defoliations have been studied and modelled (Salette and Lemaire, 1981; Salette, 1982; Salette et al., 1982). This paper gives a generalization of the growth dilution and uptake model for nutrient minerals.


Measuring Perceived Stress Levels And Physiological Variables In Undergraduate College Students: A Quasi-Experimental Study, Sarah J. Milner Mar 2025

Measuring Perceived Stress Levels And Physiological Variables In Undergraduate College Students: A Quasi-Experimental Study, Sarah J. Milner

The Interactive Journal of Global Leadership and Learning

This study aimed to analyze changes in perceived stress and physiological variables in undergraduate students over one semester. A quasi-experimental study was conducted using non-random convenience sampling with 30 undergraduate students enrolled in an Introduction to Stress Management class at a small, regional institution in the upper Midwest in the fall of 2022.

Data collection included the use of the Perceived Stress Scale (i.e., PSS-10) and stress physiological variables (e.g., heart rate, breathing pattern, respiration rate). Participants were surveyed three times using pre-, mid-, and post-treatment assessments but ultimately, participants’ pre- and post-treatment surveys were compared. Both descriptive statistics and …


Investigating Racial Attitudes In Higher Education Student Affairs Professionals Using The Color-Blind Racial Attitudes Scale (Cobras), Cindy Boe Mar 2025

Investigating Racial Attitudes In Higher Education Student Affairs Professionals Using The Color-Blind Racial Attitudes Scale (Cobras), Cindy Boe

The Interactive Journal of Global Leadership and Learning

Abstract

While the literature has documented the existence of colorblind racism in college students and faculty members, data about student affairs professionals (SAPs) are not yet clear. The purpose of this quasi-experimental interventional single group research was to assess SAPs using the Color-Blind Racial Attitudes Scale (CoBRAS) to investigate whether colorblind racism is present within the culture of the student affairs profession. A pretest involved survey questions about Diversity, Equity and Inclusion (DEI) statements and actions within higher education and reactions to quotations from public figures about race and society. Following a brief self-reflection about racial identity and related access …


Unh Research Shows Nerve Cells Move Backward To Reposition Contributing To Brain Evolution, Robbin Ray Mar 2025

Unh Research Shows Nerve Cells Move Backward To Reposition Contributing To Brain Evolution, Robbin Ray

Media Relations

No abstract provided.


The Antelope, University Of Nebraska At Kearney Mar 2025

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.


Floodfriend, Lauren Watson Mar 2025

Floodfriend, Lauren Watson

College of Computing and Digital Media Dissertations

Floodfriend is a two-dimensional puzzle-platformer game with two main characters that are trying to navigate their way out of a cave system. The player controls both the human and the monster of the duo: the hiker responds to direct arrow key input, while the monster can only be persuaded by using the hiker’s flashlight to swim and climb to otherwise inaccessible areas. The game is equal parts a simulation and a toy, encouraging the player to try different methods of interaction to garner the results they want to see. From a design perspective, the game is centered on the push …


Ex Libris, Spring 2025, West Virginia University Libraries Mar 2025

Ex Libris, Spring 2025, West Virginia University Libraries

Ex Libris: The WVU Libraries Magazine

The West Virginia University Libraries magazine, Ex Libris, is produced and printed through the support of library donors.

AOTUS SPENDS DAY WITH WVRHC The Archivist of the United States visited WVU Morgantown for a series of visits and tours, and chatted with WVU Libraries in an exclusive Q & A interview.

RISING TO MEET RESEARCH NEEDS WVU Libraries and the WVU Research Office are empowering University researchers, paving the way to advances in research and science.

CENTERING STUDENT SUCCESS AMIDST CHANGE The hybrid introduction to Library Research course isn't your average college course. WVU librarians are innovating to make information …


Worldwide Innovative Network (Win) Consortium In Personalized Cancer Medicine: Bringing Next-Generation Precision Oncology To Patients., Wafik S El-Deiry, Catherine Bresson, Fanny Wunder, Benedito A Carneiro, Don S Dizon, Jeremy L Warner, Stephanie L Graff, Christopher G Azzoli, Eric T Wong, Liang Cheng, Sendurai A Mani, Howard P Safran, Casey Williams, Tobias Meissner, Benjamin Solomon, Eitan Rubin, Angel Porgador, Guy Berchem, Pierre Saintigny, Amir Onn, Jair Bar, Raanan Berger, Manon Gantenbein, Zhen Chen, Cristiano De Pádua Souza, Rui Manuel Vieira Reis, Marina Sekacheva, Andrés Cervantes, William L Dahut, Christina M Annunziata, Kerri Gober, Khaled M Musallam, Humaid O Al-Shamsi, Ibrahim Abu-Gheida, Ramon Salazar, Sewanti Limaye, Adel T Aref, Roger R Reddel, Mohammed Ussama Al Homsi, Abdul Rouf, Said Dermime, Jassim Al Suwaidi, Catalin Vlad, Rares Buiga, Amal Al Omari, Hikmat Abdel-Razeq, Luis F Oñate-Ocaña, Finn Cilius Nielsen, Leah C. Graham, Jens Rueter, Anthony M Joshua, Eugenia Girda, Steven Libutti, Gregory Riedlinger, Mohammed E Salem, Carol J Farhangfar, Ruben A Mesa, Bishoy M Faltas, Olivier Elemento, C S Pramesh, Manju Sengar, Satoru Aoyama, Sadakatsu Ikeda, Ioana Berindan-Neagoe, Himabindu Gaddipati, Mandar Kulkarni, Elisabeth Auzias, Maria Gerogianni, Nicolas Wolikow, Simon Istolainen, Pessie Schlafrig, Naftali Z Frankel, Amanda R Ferraro, Jim Palma, Alejandro Piris Gimenez, Alberto Hernando-Calvo, Enriqueta Felip, Apostolia M Tsimberidou, Roy S Herbst, Josep Tabernero, Richard L Schilsky, Jia Liu, Yves Lussier, Jacques Raynaud, Gerald Batist, Shai Magidi, Razelle Kurzrock Mar 2025

Worldwide Innovative Network (Win) Consortium In Personalized Cancer Medicine: Bringing Next-Generation Precision Oncology To Patients., Wafik S El-Deiry, Catherine Bresson, Fanny Wunder, Benedito A Carneiro, Don S Dizon, Jeremy L Warner, Stephanie L Graff, Christopher G Azzoli, Eric T Wong, Liang Cheng, Sendurai A Mani, Howard P Safran, Casey Williams, Tobias Meissner, Benjamin Solomon, Eitan Rubin, Angel Porgador, Guy Berchem, Pierre Saintigny, Amir Onn, Jair Bar, Raanan Berger, Manon Gantenbein, Zhen Chen, Cristiano De Pádua Souza, Rui Manuel Vieira Reis, Marina Sekacheva, Andrés Cervantes, William L Dahut, Christina M Annunziata, Kerri Gober, Khaled M Musallam, Humaid O Al-Shamsi, Ibrahim Abu-Gheida, Ramon Salazar, Sewanti Limaye, Adel T Aref, Roger R Reddel, Mohammed Ussama Al Homsi, Abdul Rouf, Said Dermime, Jassim Al Suwaidi, Catalin Vlad, Rares Buiga, Amal Al Omari, Hikmat Abdel-Razeq, Luis F Oñate-Ocaña, Finn Cilius Nielsen, Leah C. Graham, Jens Rueter, Anthony M Joshua, Eugenia Girda, Steven Libutti, Gregory Riedlinger, Mohammed E Salem, Carol J Farhangfar, Ruben A Mesa, Bishoy M Faltas, Olivier Elemento, C S Pramesh, Manju Sengar, Satoru Aoyama, Sadakatsu Ikeda, Ioana Berindan-Neagoe, Himabindu Gaddipati, Mandar Kulkarni, Elisabeth Auzias, Maria Gerogianni, Nicolas Wolikow, Simon Istolainen, Pessie Schlafrig, Naftali Z Frankel, Amanda R Ferraro, Jim Palma, Alejandro Piris Gimenez, Alberto Hernando-Calvo, Enriqueta Felip, Apostolia M Tsimberidou, Roy S Herbst, Josep Tabernero, Richard L Schilsky, Jia Liu, Yves Lussier, Jacques Raynaud, Gerald Batist, Shai Magidi, Razelle Kurzrock

Faculty Research 2025

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology. The Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine founded by Drs. John Mendelsohn and Thomas Tursz provided a vision for innovation, collaboration and global impact in precision oncology. Through pursuit of transcriptomic signatures, artificial intelligence (AI) algorithms, global precision cancer medicine clinical trials and input from an international Molecular Tumor …


Influence Of Inselbergs On Bat Diversity In Afrotropical Ecosystems, Amanda Lee Grunwald Mar 2025

Influence Of Inselbergs On Bat Diversity In Afrotropical Ecosystems, Amanda Lee Grunwald

Dissertations and Theses

Humans are altering biological communities on local to global scales, driving profound changes in biodiversity and ecosystem functioning. However, significant gaps and biases in biodiversity data hinder our understanding of ecosystem interactions, making it challenging to develop effective, data-driven policies to protect remaining biodiversity. Bats, the second most species-rich groups of mammals, have a global distribution, and perform a broad array of vital ecosystem functions. Their diversity peaks in the tropics, where they often constitute more than 50% of mammal species diversity. The Afrotropics host substantial bat diversity, yet have historically been perceived as having lower species richness compared to …


The Bg News March 12, 2025, Bowling Green State University Mar 2025

The Bg News March 12, 2025, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. March 12, 2025. Volume 104-Issue 20.


Paternal Origin Of Yi People In Southwestern China: Insights From Phylogeographics Of Founder Lineage, Shi-Jie Xie, Jia-Ni Lu, Hui Li, Xian-Peng Zhang, Lan-Hai Wei Mar 2025

Paternal Origin Of Yi People In Southwestern China: Insights From Phylogeographics Of Founder Lineage, Shi-Jie Xie, Jia-Ni Lu, Hui Li, Xian-Peng Zhang, Lan-Hai Wei

Human Biology Open Access Pre-Prints

The Yi people in southwestern China are renowned for their unique history, social structure, and customs. However, due to extensive genetic admixture during their formative period, the early origin and evolutionary trajectory of the Yi people remain unclear. In this study, we identified four paternal founder lineages of Yi people and generated a highly revised phylogenetic tree for these four lineages with sixty-six sequences. Furthermore, the geographic distribution of four lineages within China was summarized, based on 465 individuals identified among 60,009 Chinese males. The divergence topology indicated that among all Tibeto-Burman-speaking populations, the Naxi, Bai, and Burmese populations exhibit …


Synthesis Of A Series Of Rare-Earth-Based Multi-Anion Chalcogenide Iodides Re3Si2SeXS8-XI (Re = La, Ce, Pr, And Nd) Using The Flux-Assisted Boron-Chalcogen Mixture Method, Gopabandhu Panigrahi, Habiba Binte Kashem, Gregory Morrison, Hans Conrad Zur Loye Mar 2025

Synthesis Of A Series Of Rare-Earth-Based Multi-Anion Chalcogenide Iodides Re3Si2SeXS8-XI (Re = La, Ce, Pr, And Nd) Using The Flux-Assisted Boron-Chalcogen Mixture Method, Gopabandhu Panigrahi, Habiba Binte Kashem, Gregory Morrison, Hans Conrad Zur Loye

Faculty Publications

Single crystals and polycrystalline powders of rare earth mixed chalcogenide iodides La3Si2Se1.21S6.79I, Ce3Si2Se1.39S6.61I, Pr3Si2Se1.22S6.78I, and Nd3Si2Se1.18S6.82I were prepared using the reactive flux-assisted boron-chalcogen mixture (BCM) method at 850 °C. All compounds crystallized in the monoclinic crystal system, space group C2/c (space group number 15). The series adopts the La3Si2O8Cl structure type, containing isolated SiQ4 tetrahedra connected by REQ8 (RE = La, Ce, Pr and Nd) polyhedra; this arrangement creates tunnels that are filled by I atoms. The partial substitution of S by Se was carried out to modulate the optical properties. Phase pure samples and uniform solid solutions were obtained …


General Biology 2 Laboratory Manual: In Person Edition, Dmitry Y. Brogun, Azure N. Faucette, Farshad Tamari, Kristin Polizzotto Mar 2025

General Biology 2 Laboratory Manual: In Person Edition, Dmitry Y. Brogun, Azure N. Faucette, Farshad Tamari, Kristin Polizzotto

Open Educational Resources

The completed project is an in-person teaching version of the General Biology II OER (Open Educational Resource) lab manual. This lab manual was initially written by the four of us during the pandemic when all courses were online, but it is now has been adapted for in-person lab activities. We also ensured it aligns with UDL (Universal Design for Learning) and accessibility principles. This adaptation aims to make the lab manual suitable for traditional classroom settings while incorporating diverse teaching practices to accommodate diverse learners.


Respiratory Muscle Training Reduces Painful Swallowing And Opioid Use During Radiation Therapy For Head And Neck Cancer: A Matched Pair Analysis, Andrew D. Ray, Chi-Chen Hong, Nicolas F. Schlecht, Han Yu, Kristopher Attwood, Kent L. Nastiuk, Bryan A. Spinelli, Ann Marie Flores, Hillary Jacobson, Julia Fulfaro, M. Jeffrey Mador, Austin J. Iovoli, Mark K. Farrugia, Anurag K. Singh Mar 2025

Respiratory Muscle Training Reduces Painful Swallowing And Opioid Use During Radiation Therapy For Head And Neck Cancer: A Matched Pair Analysis, Andrew D. Ray, Chi-Chen Hong, Nicolas F. Schlecht, Han Yu, Kristopher Attwood, Kent L. Nastiuk, Bryan A. Spinelli, Ann Marie Flores, Hillary Jacobson, Julia Fulfaro, M. Jeffrey Mador, Austin J. Iovoli, Mark K. Farrugia, Anurag K. Singh

Department of Physical Therapy Faculty Papers

BACKGROUND: Patients with head and neck cancer (HNC) receiving radiation therapy (RT) are at increased risk for symptoms of oral mucositis (OM), opioid use, and declines in physical function, outcomes that contribute to increased morbidity and mortality. The study objective was to determine the effects of respiratory muscle training (RMT) on OM and opioid use, as well as functional performance in patients with HNC receiving RT with or without concurrent chemotherapy (CCRT).

METHODS: Patients aged ≥ 18 years of age with stage I to IV HNC being treated with RT or CCRT receiving a home-based respiratory muscle training (RMT) (n …


Commodity Thermoplastic Elastomer-Enabled Templated Synthesis Of Large-Pore Ordered Mesoporous Materials, Anthony Griffin, Parker Frame, Yizhi Xiang, Zhe Qiang Mar 2025

Commodity Thermoplastic Elastomer-Enabled Templated Synthesis Of Large-Pore Ordered Mesoporous Materials, Anthony Griffin, Parker Frame, Yizhi Xiang, Zhe Qiang

Faculty Publications

Fabrication of ordered mesoporous materials (OMMs) has predominantly relied on templating-based methods. However, these methods are constrained by several limitations, especially the limited pore sizes attainable with commercially available surfactants used as structure-directing agents. To unlock the full potential of the OMMs, it is essential to develop synthetic strategies that facilitate the production of large-pore OMMs using scalable processes and cost-effective precursors. This work demonstrates the use of thermoplastic elastomer (TPE)-derived carbon replicas for synthesizing ordered mesoporous silica (OMS) and metal oxides (OMMOs) via precursor infiltration and template removal. The nanostructural evolution of the resulting inorganic materials was systematically investigated. …


The Binding Of Cu2+ To Lipid Membranes Is Not Substantially Influenced By Electrostatic Screening, Christopher M. Reynolds, Olivia C. Fiebig, Alexa Marroquin, Andrew J. Glaid, Kushaal Chokhany, Ryan G. Zdenek, Maria Laura Da Cruz Garcia, Paul S. Cremer Mar 2025

The Binding Of Cu2+ To Lipid Membranes Is Not Substantially Influenced By Electrostatic Screening, Christopher M. Reynolds, Olivia C. Fiebig, Alexa Marroquin, Andrew J. Glaid, Kushaal Chokhany, Ryan G. Zdenek, Maria Laura Da Cruz Garcia, Paul S. Cremer

Chemistry: Faculty Publications

Gouy-Chapman theory predicts that salt screening and modulating the interfacial charge density should strongly influence the apparent dissociation constant, Kd,app, between Cu2+ and negatively charged phosphatidylserine (PS) lipids in supported lipid bilayers (SLBs). Specifically, Kd,app would be expected to increase (weaken binding) by a factor of 40 when 100 mM NaCl is introduced into the solution because of electrostatic screening between the membrane and Cu2+ cations. Surprisingly, however, fluorescence quenching measurements demonstrate that Kd,app increases by less than a factor of 2 when increasing the salt concentration in the presence of standard buffers, such as tris(hydroxymethyl)aminomethane (Tris). Moreover, …


Breaking Binaries: Gender Non-Conforming Lesbians And The Undercurrent Of Biopower On Dating Apps, Lily M. Connolly Mar 2025

Breaking Binaries: Gender Non-Conforming Lesbians And The Undercurrent Of Biopower On Dating Apps, Lily M. Connolly

USF Tampa Graduate Theses and Dissertations

This study examines how gender nonconforming lesbians experience and navigate algorithmic constraints, commodification, and self-expression on dating apps. Drawing on Michel Foucault’s concept of biopower, this study analyzes focus group discussions to argue that dating apps encode and enforce traditional gender norms. However, rather than acting solely as sites of constraint, dating apps also provide spaces where gender nonconforming lesbians creatively resist these limitations and subvert platform design to assert their politicized queer identities. This research highlights how biopower operates within digital dating platforms while also illuminating the subversive strategies users employ to reclaim agency. By situating gender nonconforming lesbian …


Cost-Effective Active Laser Scanning System For Depth-Aware Deep-Learning-Based Instance Segmentation In Poultry Processing, Pouya Sohrabipour, Chaitanya Kumar Reddy Pallerla, Amirreza Davar, Siavash Mahmoudi, Philip Crandall, Wan Shou, Yu She, Dongyi Wang Mar 2025

Cost-Effective Active Laser Scanning System For Depth-Aware Deep-Learning-Based Instance Segmentation In Poultry Processing, Pouya Sohrabipour, Chaitanya Kumar Reddy Pallerla, Amirreza Davar, Siavash Mahmoudi, Philip Crandall, Wan Shou, Yu She, Dongyi Wang

School of Industrial Engineering Faculty Publications

The poultry industry plays a pivotal role in global agriculture, with poultry serving as a major source of protein and contributing significantly to economic growth. However, the sector faces challenges associated with labor-intensive tasks that are repetitive and physically demanding. Automation has emerged as a critical solution to enhance operational efficiency and improve working conditions. Specifically, robotic manipulation and handling of objects is becoming ubiquitous in factories. However, challenges exist to precisely identify and guide a robot to handle a pile of objects with similar textures and colors. This paper focuses on the development of a vision system for a …


Impact Of Changes In Gestational Diabetes Mellitus Diagnostic Criteria During The Covid-19 Pandemic, Jessica Neville, Kelly Foley, Seán Lacey, Antoinette Tuthill, Oratile Kgosidialwa, Mairead O’Riordan, Fiona O’Halloran, Seán J. Costelloe Mar 2025

Impact Of Changes In Gestational Diabetes Mellitus Diagnostic Criteria During The Covid-19 Pandemic, Jessica Neville, Kelly Foley, Seán Lacey, Antoinette Tuthill, Oratile Kgosidialwa, Mairead O’Riordan, Fiona O’Halloran, Seán J. Costelloe

Department of Biological Sciences Publications

Background/Aims

During the COVID-19 pandemic, the Health Service Executive (HSE) and Royal College of Obstetricians and Gynaecologists (RCOG) recommended fasting and random plasma glucose (FPG/RPG) alongside glycated haemoglobin (HbA1c) to replace the oral glucose tolerance test (OGTT) for diagnosing Gestational Diabetes Mellitus (GDM).

Methods

The study compared testing patterns and diagnostic rates for GDM before and after implementing the RCOG guidelines (01/05/2020) in pregnancies beginning 01/11/2018 to 31/03/2021. Trends were inspected using Cochrane-Armitage tests. Differences between General Practice (GP) and Secondary Care (SCare) were assessed by chi-square analysis. A significance level of p <  0.05 was used for all analyses. Information on maternal and pregnancy characteristics was accessed where available.

Results

Data indicated a significant reduction in …


Redefining The Limits Of Functional Continuity In The Early Evolution Of P-Loop Ntpases, Andrey O. Demkiv, Saacnicteh Toledo-Patiño, Encarnación Medina-Carmona, Andrej Berg, Gaspar P. Pinto, Antonietta Parracino, Jose M. Sanchez-Ruiz, Alvan C. Hengge, Paola Laurino, Liam M. Longo, Shina Caroline Lynn Kamerlin Mar 2025

Redefining The Limits Of Functional Continuity In The Early Evolution Of P-Loop Ntpases, Andrey O. Demkiv, Saacnicteh Toledo-Patiño, Encarnación Medina-Carmona, Andrej Berg, Gaspar P. Pinto, Antonietta Parracino, Jose M. Sanchez-Ruiz, Alvan C. Hengge, Paola Laurino, Liam M. Longo, Shina Caroline Lynn Kamerlin

Chemistry and Biochemistry Faculty Publications

At the heart of many nucleoside triphosphatases is a conserved phosphate-binding sequence motif. A current model of early enzyme evolution proposes that this six to eight residue motif could have sparked the emergence of the very first nucleoside triphosphatases—a striking example of evolutionary continuity from simple beginnings, if true. To test this provocative model, seven disembodied Walker A-derived peptides were extensively computationally characterized. Although dynamic flickers of nest-like conformations were observed, significant structural similarity between the situated peptide and its disembodied counterpart was not detected. Simulations suggest that phosphate binding is nonspecific, with a preference for GTP over orthophosphate. Control …


Associations Of Sociodemographic, Clinical Factors And Hla-B Alleles With Enthesitis And Peripheral Arthritis In Patients With Ankylosing Spondylitis, Benjamin Sornrung Naovarat, Lianne Gensler, Michael Ward, Mark Hwang, Amirali Tahanan, Mohammad Hossein Rahbar, Mariko Ishimori, Minjae Lee, Matthew A Brown, Michael H Weisman, John D Reveille Mar 2025

Associations Of Sociodemographic, Clinical Factors And Hla-B Alleles With Enthesitis And Peripheral Arthritis In Patients With Ankylosing Spondylitis, Benjamin Sornrung Naovarat, Lianne Gensler, Michael Ward, Mark Hwang, Amirali Tahanan, Mohammad Hossein Rahbar, Mariko Ishimori, Minjae Lee, Matthew A Brown, Michael H Weisman, John D Reveille

Faculty, Staff and Student Publications

Objectives: Factors associated with peripheral arthritis and enthesitis, especially Achilles tendonitis and plantar fasciitis, were examined in a longitudinal cohort of 1075 patients with ankylosing spondylitis (AS) (also known as radiographic axial spondyloarthritis).

Methods: Patients were derived from the Prospective Study of Outcomes in Ankylosing Spondylitis cohort. Disease activity and functional indices, as well as physical examination and medications used, were measured at every study visit. Univariable and multivariable analyses of the association of peripheral arthritis and enthesitis with clinical, sociodemographic factors were performed. Human leucocyte antigen (HLA)-B alleles were analysed by single-stranded conformational polymorphism analysis.

Results: Those with peripheral …


2025-03-12 Breaking News On Break: Seattle U Considers Academic Schedule Change, Dylan Berman Mar 2025

2025-03-12 Breaking News On Break: Seattle U Considers Academic Schedule Change, Dylan Berman

The Spectator Online

No abstract provided.


2025-03-12 Seattle U Shoppers Respond To Eggstra Costs, Naja Johnson Mar 2025

2025-03-12 Seattle U Shoppers Respond To Eggstra Costs, Naja Johnson

The Spectator Online

No abstract provided.


Spartan Daily, March 12, 2025, San Jose State University, School Of Journalism And Mass Communications Mar 2025

Spartan Daily, March 12, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 21


Control Of Clostridioides Difficile Virulence And Physiology By The Flagellin Homeostasis Checkpoint Flic-Fliw-Csra In The Absence Of Motility, Duolong Zhu, Katherine J Wozniak, Firas Midani, Shaohui Wang, Xingmin Sun, Robert A Britton Mar 2025

Control Of Clostridioides Difficile Virulence And Physiology By The Flagellin Homeostasis Checkpoint Flic-Fliw-Csra In The Absence Of Motility, Duolong Zhu, Katherine J Wozniak, Firas Midani, Shaohui Wang, Xingmin Sun, Robert A Britton

Faculty, Staff and Students Publications

Mutations affecting Clostridioides difficile flagellin (FliC) have been shown to be hypervirulent in animal models and display increased toxin production and alterations in central metabolism. The regulation of flagellin levels in bacteria is governed by a tripartite regulatory network involving fliC, fliW, and csrA, which creates a feedback system to regulate flagella production. Through genomic analysis of C. difficile clade 5 strains (non-motile), we identified they have jettisoned many of the genes required for flagellum biosynthesis yet retain the major flagellin gene fliC and regulatory gene fliW. We therefore investigated the roles of fliC, fliW …


Overexpression And Biophysical And Functional Characterization Of A Recombinant Fgf21, Phuc Phan, Jason Hoang, Thallapuranam Krishnaswamy Suresh Kumar Mar 2025

Overexpression And Biophysical And Functional Characterization Of A Recombinant Fgf21, Phuc Phan, Jason Hoang, Thallapuranam Krishnaswamy Suresh Kumar

Chemistry & Biochemistry Faculty Publications and Presentations

Fibroblast growth factor 21 (FGF21) is an endocrine FGF that plays a vital role in regulating essential metabolic pathways. FGF21 increases glucose uptake by cells, promotes fatty acid oxidation, reduces blood glucose levels, and alleviates metabolic diseases. However, detailed studies on its stability and biophysical characteristics have not been reported. Herein, we present the overexpression, biophysical characterization, and metabolic activity of a soluble recombinant FGF21 (rFGF21). The far-UV circular dichroism spectra of rFGF21 show a negative trough at 215 nm, indicating that the protein's backbone predominantly adopts a 13 sheet conformation. rFGF21 shows intrinsic tyrosine fluorescence at 305 nm. Thermal …