Digital Commons Network^™

Prey Size Mediates Interference Competition And Predation Dynamics In A Large Carnivore Community, Jack W. Rabe, Wesley J. Binder, Colby B. Anton, Connor J. Meyer, Matthew C. Metz, Brian J. Smith, Toni K. Ruth, Kerry M. Murphy, Joseph K. Bump, Douglas W. Smith, Daniel R. Stahler

Wildland Resources Faculty Publications

Direct competition for resources is especially fierce among predators, leading to disproportionately strong effects on fitness and functional roles. These competitive effects are exacerbated in complex predator guilds with dominance hierarchies that have clear winners and losers. The direct costs of losing these competitions are well understood, but the drivers of such interactions, and their indirect effects on prey, are not. We evaluate the drivers of interference competition for cougars, and how such competition affects cougar-prey dynamics, by leveraging 23 years of cougar predation data from Yellowstone National Park, USA. We show that the effect of prey size is context-dependent, …

Research Highlights, Shruti Jain Vij, Charu Sehgal

Indian Journal of Research in Homoeopathy

Research Highlights

Real-World Impact Of Latanoprostene Bunod Ophthalmic Solution 0.024% In Glaucoma Therapy: A Narrative Review, W. Daniel Stamer, Thomas Chiu, Da-Wen Lu, Tsing Hong Wang, Prin Rojanapongpun, Ngamkae Ruangvaravate, Youn Hye Jo, Marlene R. Moster, Murray Fingeret, Nora Lee Cothran, Jessica Steen, Ian B. Gaddie, Ömür Uçakhan-Gündüz, Wesam S. Shalaby, Cindy M. L. Hutnik

Wills Eye Hospital Papers

Latanoprostene bunod ophthalmic solution (LBN) 0.024% is a topical nitric oxide (NO)-donating prostaglandin F2α (PGF2α) analog first approved in November 2017 for reduction of intraocular pressure (IOP) in patients with ocular hypertension (OHT) or open-angle glaucoma (OAG). This narrative review describes the unique mechanism of action of LBN and summarizes available real-world data. Upon instillation, LBN is metabolized into latanoprost acid and butanediol mononitrate, which is further reduced to NO and an inactive metabolite. Latanoprost acid increases aqueous humor outflow primarily through the uveoscleral (unconventional) pathway, whereas NO increases outflow through the trabecular (conventional) pathway. Eight studies were identified: 2 …

2025-03-28 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of March 28, 2025, which includes the meeting minutes of the meeting held on February 7, 2025.

Refinement Of Megakaryocyte Lineage Commitment In Hematopoietic Stem And Progenitor Cells During Postnatal And Adult Hematopoiesis, Ryan Michael Mack

Dissertations

Mammalian hematopoiesis ensures the continuous production of specialized blood cells, yet the mechanisms that govern megakaryocyte/erythroid (MK/E) bifurcation remain incompletely understood. While HSPCs sustain all blood lineages, how transient waves of progenitors arise and adapt from fetal to adult stages is less clear. This gap in knowledge limits our capacity to precisely manipulate platelet and red blood cell outputs in both developmental and therapeutic contexts. Using refined gating strategies and various bulk- and single-cell transcriptomics, we dissected the traditional “common myeloid progenitor” and Multipotent Progenitor (MPP) compartment into multiple functionally distinct subsets (C1, C2, C3). Within C1, an ESAM⁺ fraction …

Adverse Childhood Experiences And High School Dropout: The Roles Of Student Disengagement And Social Support, Rachel D. Pounders

LSU Doctoral Dissertations

More than two million students a year leave high school without a completion credential (NCES, 2024). Students who drop out are at-risk for detrimental long-term outcomes physically, mentally and economically (Rumberger, 2020). Students with adverse childhood experiences (ACEs) are significantly more likely to have poor educational outcomes, including school dropout (Metzler et al., 2017; Pan et al., 2019). However, there is limited insight into what affects the pathway between ACEs and poor educational outcomes for students (Dupéré et al., 2019; Morrow & Villodas, 2018). Informed by prominent dropout theories with ecological foundations and the theory of stress and coping, this …

Effects Of Prebiotic Phytocompound Administration In Gestational Diabetic Dams And Its Influence On Offspring Cognitive Outcomes, Gayathri Jagadeesan, Tushar K Das, Jennifer M Mendoza, Ghalya Alrousan, Maria P Blasco-Conesa, Parimelazhagan Thangaraj, Bhanu Priya Ganesh

Faculty, Staff and Student Publications

Gestational diabetes mellitus (GD)-induced gut dysbiosis in pregnant mothers may increase the risk of cognitive impairment and neurological disorders in both the mother and offspring as they age. Restoring gut balance could improve cognitive outcomes for both. Despite advancements in GD treatment, side effects have increased, and long-term neurocognitive impacts on offspring born to GD mothers remain underexplored. This study uses a GD mouse model, inducing pancreatic dysfunction in 3-month-old pregnant C57BL/6J mice with Streptozotocin. The efficacy and mechanism of the prebiotic phytocompound green leaf extract (

Cigarette Smoke Induces Angiogenic Activation In The Cancer Field Through Dysregulation Of An Endothelial Microrna, Asawari Korde, Anuradha Ramaswamy, Seth Anderson, Lei Jin, Jian-Ge Zhang, Buqu Hu, Walter V Velasco, Lixia Diao, Jing Wang, Margaret A Pisani, Maor Sauler, Daniel J Boffa, Jonathan T Puchalski, Xiting Yan, Seyed Javad Moghaddam, Shervin S Takyar

Faculty, Staff and Student Publications

Cigarette smoke (CS) creates a "cancer field" in the lung that promotes malignant transformation. The molecular changes within this field are not fully characterized. We examined the significance of microRNA-1 (miR-1) downregulation as one of these changes. We found that tumor miR-1 levels in three non-small cell lung cancer cohorts show inverse correlations with the smoking burden. Lung MiR-1 levels follow a spatial gradient, have prognostic significance, and correlate inversely with the molecular markers of injury. In CS-exposed lungs, miR-1 is specifically downregulated in the endothelium. Exposure to CS induces angiogenesis by selectively degrading mature miR-1 via a vascular endothelial …

Assessing Cancer Therapeutic Efficacy In Vivo Using [2h7]Glucose Deuterium Metabolic Imaging, Mario C Chang, Vinay R Malut, Rohit Mahar, Anna Rushin, Marc A Mcleod, Geraldine L Pierre, Indu R Malut, Stephen J Staklinski, Max E Glanz, Mukundan Ragavan, Gaurav Sharma, Manoj Madheswaran, Arshee Badar, Aparna D Rao, Brian K Law, Michael S Kilberg, James H P Collins, Vikram D Kodibagkar, James A Bankson, Ralph J Deberardinis, Matthew E Merritt

Faculty, Staff and Student Publications

Metabolic imaging produces powerful visual assessments of organ function in vivo. Current techniques can be improved by safely increasing metabolic contrast. The gold standard, 2-[18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging, is limited by radioactive exposure and sparse assessment of metabolism beyond glucose uptake and retention. Deuterium magnetic resonance imaging (DMRI) with [6,6-2H2]glucose is nonradioactive, achieves tumor metabolic contrast, but can be improved by enriched contrast from deuterated water (HDO) based imaging. Here, we developed a DMRI protocol employing [2H7]glucose. Imaging 2H-signal and measuring HDO production in tumor-bearing mice detected differential glucose utilization across baseline tumors, tumors treated with vehicle control or …

Sitc Strategic Vision: Prevention, Premalignant Immunity, Host And Environmental Factors, Sasha E Stanton, Kristin G Anderson, Tullia C Bruno, Christian M Capitini, Mary L Disis, Jennifer Mcquade, Laszlo Radvanyi, Claire Vanpouille-Box, Jennifer Wargo, Kelly J Baines, Megan M Y Hong, Adnan Rajeh, Raymond H Kim, Phillip Awadalla, Lauren K Hughes, Saman Maleki Vareki

Faculty, Staff and Student Publications

Cancer immunotherapy has improved the survival of a subset of patients by harnessing the power of the immune system to find and destroy malignant cells. The immune system also protects the host by destroying developing premalignant and malignant tumors. Advancing our knowledge of premalignant immunity and immune changes seen in lesions that develop into invasive cancer versus those that regress offers an exciting opportunity to leverage the immune system for immune prevention and immune interception of premalignancy. Understanding the immune environment of premalignant lesions and how chronic inflammation plays a central role in the evolution of premalignancy is essential for …

Benefits Of Psychobiography Training To The Professional And Personal Development Of Psychology Graduate Students, Joseph G. Ponterotto, Dinesh Sharma, Yuki Yamazaki

The Qualitative Report

In recent decades, psychobiography has witnessed a resurgence of activity and publication across many subdisciplines in psychology internationally. One area of recent research has been to evaluate the benefits of training in psychobiography to students’ professional development as perceived by professors and mentors in psychobiography. The present study extends this recent line of research by surveying the perceived impacts of psychobiography training among doctoral students in applied psychology. Twenty-five doctoral students who completed training and research in psychobiography in a summer course over three consecutive years, responded to an open-ended (free response) survey on the impact of conducting psychobiographies on …

"The Letting Of Blood": Evolutionary Perspectives On Violence In Cormac Mccarthy’S Western Worlds, Nicholas Adam Pankewycz

Electronic Theses and Dissertations Archive

Abstract: Pankewycz, Nicholas Adam. PhD. The University of Memphis. December 2024. “the letting of blood”: Evolutionary Perspectives on Violence in Cormac McCarthy’s Western Worlds. Theron Britt PhD. Through a close analysis of Cormac McCarthy's Western oeuvre, the dissertation examines how his depiction of violence reflects fundamental aspects of human nature, suggesting that the aggressive behaviors portrayed are inherent and shaped by environmental and evolutionary pressures. McCarthy's unflinching narratives provide insight into the darker facets of humanity, depicting scenes of brutality that challenge readers to confront the pervasive nature of violence in both American history and the human species. By situating …

Notrica '26 Speaks At International Mold Conference, Grows Fermentation Business, Julia Perez

Press Releases 2020-2029

No abstract provided.

2025-03-28, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

An In Vivo Screen Identifies Nat10 As A Master Regulator Of Brain Metastasis, Jocelyn F Chen, Peng Xu, Wesley L Cai, Huacui Chen, Emily Wingrove, Xiaojian Shi, Wenxue Li, Giulia Biancon, Meiling Zhang, Amer Balabaki, Ethan D Krop, Elianna Asare, Yangyi Zhang, Mingzhu Yin, Toma Tebaldi, Jordan L Meier, Thomas F Westbrook, Stephanie Halene, Yansheng Liu, Hongying Shen, Don X Nguyen, Qin Yan

Faculty, Staff and Students Publications

Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis, the major cause of cancer-related deaths. Here, we conducted an in vivo screen for vulnerabilities of brain metastasis and identified N-acetyltransferase 10 (NAT10) as a driver of brain metastasis. Knockdown of NAT10 restrains cancer cell proliferation and migration in vitro and tumor growth and brain metastasis in vivo. The poorly characterized RNA helicase domain of NAT10 is critical for cell growth in vitro, while both RNA helicase and NAT domains are essential for primary tumor growth and brain metastasis in vivo. Mechanically, NAT10 promotes the …

An In Vivo Screen Identifies Nat10 As A Master Regulator Of Brain Metastasis, Jocelyn F Chen, Peng Xu, Wesley L Cai, Huacui Chen, Emily Wingrove, Xiaojian Shi, Wenxue Li, Giulia Biancon, Meiling Zhang, Amer Balabaki, Ethan D Krop, Elianna Asare, Yangyi Zhang, Mingzhu Yin, Toma Tebaldi, Jordan L Meier, Thomas F Westbrook, Stephanie Halene, Yansheng Liu, Hongying Shen, Don X Nguyen, Qin Yan

Faculty, Staff and Students Publications

Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis, the major cause of cancer-related deaths. Here, we conducted an in vivo screen for vulnerabilities of brain metastasis and identified N-acetyltransferase 10 (NAT10) as a driver of brain metastasis. Knockdown of NAT10 restrains cancer cell proliferation and migration in vitro and tumor growth and brain metastasis in vivo. The poorly characterized RNA helicase domain of NAT10 is critical for cell growth in vitro, while both RNA helicase and NAT domains are essential for primary tumor growth and brain metastasis in vivo. Mechanically, NAT10 promotes the …

The Emergence Of Human Primordial Germ Cell-Like Cells In Stem Cell-Derived Gastruloids, Jitesh Neupane, Gabriele Lubatti, Theresa Gross-Thebing, Mayra Luisa Ruiz Tejada Segura, Richard Butler, Sargon Gross-Thebing, Sabine Dietmann, Antonio Scialdone, M Azim Surani

2020-Current year OA Pubs

Most advances in early human postimplantation development depend on animal studies and stem cell-based embryo models. Here, we present self-organized three-dimensional human gastruloids (hGs) derived from embryonic stem cells. The transcriptome profile of day 3 hGs aligned with Carnegie stage 7 human gastrula, with cell types and differentiation trajectories consistent with human gastrulation. Notably, we observed the emergence of nascent primordial germ cell-like cells (PGCLCs), but without exogenous bone morphogenetic protein (BMP) signaling, which is essential for the PGCLC fate. A mutation in the

Studies On Cell Cycle Regulation And Ecm Modification During Tubular Organ Formation In Drosophila Embryos, Jeffrey Matthew

LSU Doctoral Dissertations

The formation of tubular organs—such as the heart and kidneys—is a complex developmental process that requires the precise coordination of tissue remodeling with dynamic changes in cellular behavior. Key processes including cell proliferation, apoptosis, and extracellular matrix (ECM) formation must be tightly synchronized with mechanisms that generate and transmit physical forces, transforming a flat epithelial sheet into a three-dimensional organ. Disruptions in the homeostasis of these processes during organogenesis can lead to congenital defects, such as pulmonary atresia and renal hypoplasia.

To investigate the mechanisms underlying epithelial morphogenesis, the Chung laboratory employs the Drosophila embryonic salivary gland (SG) as a …

Use Of Biochar And Industrial Hemp For Remediation Of Heavy-Metal-Contaminated Soil: Root Uptake And Translocations For Cd, Pb, And Zn, Sophie Sward, Kristofor R. Brye, David M. Miller, Dietrich V. Thurston

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Phytoremediation has been reported as a more energy-efficient, and therefore cost-effective, method of environmental restoration compared to traditional remediation methods for heavy-metal-contaminated soils. Biochar has been shown to have variable effects on remediation potential in heavy-metal-contaminated soils. The objective of this study was to evaluate the effects of soil contamination level (i.e., low, medium, and high), industrial hemp (Cannabis sativa L.) cultivar (i.e., ‘Carmagnola’ and ‘Jinma’), biochar rate (i.e., 0, 2, 5, and 10% by volume), and their interactions on root tissue Cd, Pb, and Zn concentrations and uptakes; whole-plant Cd, Pb, and Zn uptakes; and translocation factors after 90 …

Characterization Of Hepatic Pathology During Azoxymethane-Induced Acute Liver Failure, Shadikchhya Maya Bhattarai, Ashwin Jhawer, Gabriel Frampton, Eleonora Troyanovskaya, Sharon Demorrow, Matthew Mcmillin

Faculty, Staff and Students Publications

Background: Acute liver failure (ALF) is a loss of liver function due to a severe hepatic insult. Studies utilizing the azoxymethane (AOM) mouse model of ALF, which also generates hepatic encephalopathy, have primarily focused on development of neurological deficits. However, the molecular processes that generate liver damage have not been fully characterized. Therefore, a more comprehensive characterization of the hepatic consequences of AOM toxicity is needed to better understand this disease model.

Aim: To identify molecular pathology contributing to hepatic injury during the progression of AOM-induced ALF.

Methods: C57BL/6 mice were injected with AOM to produce ALF and hepatic encephalopathy. …

The Shorthorn: May 30, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: May 02, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: April 04, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: March 28, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: March 14, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: December 06, 1932

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

Monitoring Population Pressure In The Semiarid Zone Of Kenya, Isaac Sindiga

The Geographical Bulletin

Population pressure is a maladjustment between resources of a community and its population. This maladjustment worsens when the population increases at a faster rate than the development of the economy. The pressure leads to the deterioration of land resources and low, risky income opportunities and widespread poverty. Kenya's population growth rate of 4 percent per year is one of the highest in the world. Its populationresource relations are deteriorating and foreshadow the country's future. In the semi-arid and arid parts of the country, especially those occupied by traditional pastoral people, population pressures are particularly serious. Here, the pressures of people …

Volume 26 Complete Issue, Robert M. Ward

The Geographical Bulletin

Volume 26 Complete Issue

The Syrian Tabqa Dam: Its Development And Impact, Monib Ei-Khatib

The Geographical Bulletin

The Euphrates River has its sources in eastern Turkey's Anatolian Plateau and extends 3,000 kilometers through Syria and Iraq before it discharges into the river's delta at Shat AI-Arab in the Arabian Gulf. It is an exotic river, a center of past civilization and population, and a managed river with an extensive delta. It floods in early summer but its flooded area dries-out very quickly in the semiarid climate. The Euphrates River can maintain an annual flow throughout its course because of relatively high rainfall and snow-melt at higher elevations. Utilization of its drainage basin has been intensified from its …

Volume 27 Complete Issue, Robert M. Ward

The Geographical Bulletin

Volume 27 Complete Issue