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Faculty Senate Meeting Agenda And Minutes, March 31, 2025 Mar 2025

Faculty Senate Meeting Agenda And Minutes, March 31, 2025

Faculty Senate Minutes and Agendas

Agenda and minutes from the Wright State University Faculty Senate Meeting held on, March 31, 2025.


Kedudukan Hukum Anak Bawaan Dalam Perkara Kepemilikan Hak Atas Tanah Dalam Perkawinan Campuran (Studi Putusan Nomor 280/Pdt.G/2021/Pn Btm), Rana Mahirah Mar 2025

Kedudukan Hukum Anak Bawaan Dalam Perkara Kepemilikan Hak Atas Tanah Dalam Perkawinan Campuran (Studi Putusan Nomor 280/Pdt.G/2021/Pn Btm), Rana Mahirah

Indonesian Notary

Pengurusan harta warisan yang melibatkan anak kandung dan pasangan kedua menimbulkan berbagai macam celah hukum jika tidak dilaksanakan sesuai dengan ketentuan yang berlaku, terutama jika perkawinan kedua tersebut merupakan perkawinan campuran yang harus lebih diperhatikan lagi ketentuan ketentuannya terkait harta dan bendanya yang dapat menimbulkan sengketa di kemudian hari. Penelitian ini membahas tentang kedudukan anak bawaan dalam perkawinan kedua orang tuanya dan peran dan tanggung jawab terhadap notaris dalam melakukan pengurusan harta waris, dengan mengangkat kasus dalam Putusan Nomor 280/Pdt.G/2021/PN Btm. Penelitian ini menerapkan metode penelitian doktrinal dengan tipe penelitian eksplanatoris. Hasil penelitian menunjukkan bahwa anak bawaan dari perkawinan sebelumnya …


Bird Richness As A Mediator Between Greenspace And Mental Health Relationships, Sihao Chena, Huaqing Wang, Wenyan Xu Mar 2025

Bird Richness As A Mediator Between Greenspace And Mental Health Relationships, Sihao Chena, Huaqing Wang, Wenyan Xu

Landscape Architecture and Environmental Planning Faculty Publications

Neighborhood greenspaces are widely known to benefit bird diversity and human mental health. However, whether bird richness mediates the relationship between greenspace and mental health is unknown. We ascertain such mediation effects in 294 census tracts in Los Angeles City. We obtained greenspace data from one-meter resolution satellite imagery, bird species data from eBird citizen science datasets, and prevalence of poor mental health from the US Centers for Disease Control and Prevention. Mediation analysis combined with spatial error models was used to assess the mediating effects while controlling for geographic, demographic, and socio-economic factors. We found that the higher greenspace …


The Medicine From Nature; Finding The Antibacterial Power Of Essential Oils, Josi Maness, Seoyeon Kim, Eric T. Gillock Mar 2025

The Medicine From Nature; Finding The Antibacterial Power Of Essential Oils, Josi Maness, Seoyeon Kim, Eric T. Gillock

SACAD: Scholarly Activities

Essential oils are known to have pharmaceutical effects such as anti-inflammatory, antioxidant, and anticarcinogenic properties. These days, there are various types of essential oils that are commonly used for coughing or to promote good sleep.

We prepared 19 different essential oils to find the essential oil that has the most antibiotic properties by putting drops of oil on a soy agar plate with Serratia marcescens. As a result, cinnamon cassia essential oil was most effective, and five of them didn't have antibiotic properties.

We also tested with six different types of antibiotics, and as a result, only three of them …


The Impact Of Anthropogenic Infrastructure On Avian Reproductive Success: A Study Of House Wrens In Proximity To Highways, Nana-Esi Irie Hanson, Medhavi Ambardar Mar 2025

The Impact Of Anthropogenic Infrastructure On Avian Reproductive Success: A Study Of House Wrens In Proximity To Highways, Nana-Esi Irie Hanson, Medhavi Ambardar

SACAD: Scholarly Activities

Road infrastructure has multifaceted effects on bird populations, influencing various aspects of their ecology and behaviour. I investigated the impact of road infrastructure, particularly highways, on the reproductive success of House Wrens (Troglodytes aedon) in a rural area. I compared the reproductive success of House Wrens in sites close to a major highway (Sternberg Museum Nature Trail) with sites located farther away (along Big Creek) in Hays, KS. I hypothesized that House Wrens near highways would exhibit lower reproductive success. I recorded metrics of reproductive success, traffic volumes, and noise levels. House wrens at the Big Creek site had higher …


Hubungan Heart Rate Variability Dengan Global Longitudinal Strain Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Jakarta, Dwi Rendra Hadi, Lusiani Rusdi, Tri Juli Edi Tarigan, Arif Mansjoer Mar 2025

Hubungan Heart Rate Variability Dengan Global Longitudinal Strain Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Jakarta, Dwi Rendra Hadi, Lusiani Rusdi, Tri Juli Edi Tarigan, Arif Mansjoer

Jurnal Penyakit Dalam Indonesia

Introduction. Diabetes mellitus (DM) remains a major global health issue due to its direct consequences and complications, particularly cardiovascular complications. These complications are influenced by autonomic neuropathy, which can be assessed by Heart Rate Variability (HRV). Autonomic dysfunction is thought to impair heart function, which can potentially be predicted early by observing Global Longitudinal Strain (GLS). The relationship between HRV and GLS has not been extensively studied. Therefore, this study aimed to identify the relationship between HRV and GLS.

Methods. A cross-sectional study with a population of adult type 2 DM patients residing in Jakarta in December 2020. …


Women’S Health Considerations In Traumatic Brain Injury, Sindhoori Nalla Mar 2025

Women’S Health Considerations In Traumatic Brain Injury, Sindhoori Nalla

Department of Rehabilitation Medicine Faculty Papers

Purpose of Review: Biological sex differences are an important factor to consider when treating TBI, as there can be a disproportionate manifestation of symptoms and recovery process when comparing females to males. Historically, these differences have not been well studied, and there is still much to be understood as to why these differences exist. Recent Findings: A number of factors are thought to contribute to disparities with women who have a TBI, including lack of well-designed research studies focused on women, hormonal fluctuations at the time of and as a result of a TBI, psychosocial comorbidities, and societal norms/expectations. While …


Numaswitch, A Novel Biochemical Platform For Efficient Peptide And Protein Production, Christian Schwarz, Roxann Guerrette, Bach-Ngan Wetzel Mar 2025

Numaswitch, A Novel Biochemical Platform For Efficient Peptide And Protein Production, Christian Schwarz, Roxann Guerrette, Bach-Ngan Wetzel

Microbial Engineering III (MEIII)

Please click Additional Files below to see the full abstract


From Civic Duties To Democratic Mandates: The Theoretical Framework Of Mill And Tocqueville On Compulsory Voting In The U.S., Olivia Claire Luttrell Mar 2025

From Civic Duties To Democratic Mandates: The Theoretical Framework Of Mill And Tocqueville On Compulsory Voting In The U.S., Olivia Claire Luttrell

Undergraduate Honors Theses

This thesis examines the treatment of jury duty and voting in the United States through the philosophical framework of John Stuart Mill and Alexis de Tocqueville. While jury duty is legally mandated, voting remains optional, despite both civic responsibilities being foundational to democratic participation. This research explores the historical, theoretical, and practical implications of voting becoming compulsory in the United States, as it is in other democratic nations. The analysis includes a comparative case study of the impact of Australia’s mandatory voting to evaluate whether it could become compulsory in the U.S. Both philosophers offer insightful knowledge on the role …


Crispr-Induced Mutagenesis Of Arabidopsis Thaliana Gene Apetala3, Hazel Frans, Tara Phelps-Durr Mar 2025

Crispr-Induced Mutagenesis Of Arabidopsis Thaliana Gene Apetala3, Hazel Frans, Tara Phelps-Durr

SACAD: Scholarly Activities

This project aims to create CRISPR-CAS9 mutations in the APETELA3 (AP3) gene of the model plant Arabidopsis thaliana. AP3 is a class B gene critical to the petal and stamen development of Arabidopsis flowers. AP3 is defined in a MADS domain, which binds directly to DNA and may be responsible for the expression of the CaRG-box genes. AP3 works in conjunction with PISTILLATA (PI), AGAMOUS (AG), APETALA1 (AP1), and SEPALLATA (SEP) genes to specify the development in the second and third whorls of the flower. While several alleles of AP3 already exist, these alleles are strong alleles that knockout gene …


Operating Fund Budget/ Expenditure Summary Report 2024-25, Csusb Budget Office Mar 2025

Operating Fund Budget/ Expenditure Summary Report 2024-25, Csusb Budget Office

University Budget Office records

No abstract provided.


Assessment Of Nurses’ Knowledge Of Multiple Sclerosis In Morocco, Rachid Lotfi, Hind Bel Amgharia, Mourad Chikhaoui, Abdeslam El Kardoudi, Fatiha Chigr Mar 2025

Assessment Of Nurses’ Knowledge Of Multiple Sclerosis In Morocco, Rachid Lotfi, Hind Bel Amgharia, Mourad Chikhaoui, Abdeslam El Kardoudi, Fatiha Chigr

Jurnal Keperawatan Indonesia

Nurses are essential in early detection, education, symptom management, treatment administration, and care coordination for patients with multiple sclerosis (MS). This role requires both theoretical and practical knowledge. This study evaluates the knowledge level among nurses regarding multiple sclerosis in Morocco. We conducted this cross- sectional study on 326 nurses in Morocco using a purposive sampling method, which involves selecting nursing specialties that have direct contact with patients with MS, aiming to target the most relevant professionals for the study. The data are collected using an anonymous questionnaire distributed individually to participants. We opted for multi- variable logistic regression models …


Bi-Level Energy Dispatch Optimisation For Peak Load Shaving In Microgrids With Battery Storage, Mohd Fakhizan Romlie, Abid Ali, Gm Shafiullah Mar 2025

Bi-Level Energy Dispatch Optimisation For Peak Load Shaving In Microgrids With Battery Storage, Mohd Fakhizan Romlie, Abid Ali, Gm Shafiullah

Platform: A Journal of Engineering

Peak load periods in electrical networks result in significant power losses, straining generation capacity, and increasing operational costs. Strategically optimising electricity supply from battery storage-based distributed generation (DG) during these peak times can mitigate these losses and enhance grid efficiency through peak load shaving (PLS). However, electrical loads vary throughout the day and night. Thus, identifying peak and off-peak loads would be the most challenging task to complete before scheduling operations for batteries. This study presents a bi-level energy optimisation framework to identify the peak and off-peak loads and plan the energy dispatching operations for battery storage. The bi-level energy …


Practices In Single Ventricle Repairs: Insights From Computational Fluid Dynamics On Cavopulmonary Connections – A Scoping Review, Olivia K. Osuch Mar 2025

Practices In Single Ventricle Repairs: Insights From Computational Fluid Dynamics On Cavopulmonary Connections – A Scoping Review, Olivia K. Osuch

Student Works

Abstract: Single-ventricle congenital heart defects require complex surgical strategies, with computation fluid dynamics (CFD) playing a growing role in optimizing cavopulmonary connections. This scoping review examines CFD-derived insights into power loss, hepatic flow distribution (HFD), and wall shear stress (WSS) across different Fontan geometries.

Methods: A search of available peer-reviewed literature (1995-2024) identified studies using CFD models to analyze hemodynamic performance in second and third-stage single-ventricle repairs. Studies were categorized based on surgical stage, anatomical variations, modeling assumptions, and key outcomes such as power loss, HFD, and WSS.

Results: Of 30 included studies, 28 analyzed power loss, 24 evaluated HFD, …


Optimizing Transcription Efficiency Through Mutations In The T7 Rna Polymerase, Claire N. Novak Mar 2025

Optimizing Transcription Efficiency Through Mutations In The T7 Rna Polymerase, Claire N. Novak

Honors Program: Senior Projects (Public)

The production of RNA is vital for many commercial and research purposes, with one of the more notable reasons being vaccine production. The RNA polymerase, derived from T7 bacteriophage, is commonly used for RNA production due to its ability to produce full-length RNA transcripts. However, researchers have faced limitations in optimizing this polymerase. For example, the polymerase generates heterogeneous RNA products that require additional purification steps during RNA production. Here, we selected three amino acid point substitutions based on a recent publication from Moderna that showed increased RNA purity compared to the wild type T7 RNA polymerase sequence. We created …


The Effects Of Interpretation On Children Of Immigrants, Crystal Carrillo Mar 2025

The Effects Of Interpretation On Children Of Immigrants, Crystal Carrillo

Honors Program: Senior Projects (Public)

Translation focuses on converting written text from one language to another with accuracy and cultural nuance, while interpretation involves real-time verbal communication, requiring quick comprehension and delivery, often in high-pressure settings like conferences or medical appointments. This essay also explores the experiences of bilingual children who have interpreted for family members in healthcare settings. It investigates the emotional and psychological burden that arises from this role, particularly when individuals are required to interpret complex medical information, traumatic histories, or sensitive diagnoses. The findings reveal that informal family interpreters often face significant stress, social pressure, and potential emotional harm, impacting their …


Understanding The Barriers To Exclusive Breastfeeding Among Urban Indonesian Mothers, Irmawati Irmawati, Mohammad Zen Rahfiludin, Zefan Adiputra Golo, Adhani Windari, Malihah Ramadhani Rum, Risky Kusuma Hartono Mar 2025

Understanding The Barriers To Exclusive Breastfeeding Among Urban Indonesian Mothers, Irmawati Irmawati, Mohammad Zen Rahfiludin, Zefan Adiputra Golo, Adhani Windari, Malihah Ramadhani Rum, Risky Kusuma Hartono

Media Kesehatan Masyarakat Indonesia

Despite WHO recommendations advocating for Exclusive Breastfeeding (EBF) for the initial six months, EBF rates remain low in many countries, including Indonesia. This study identifies psychosocial, socioeconomic, and demographic factors influencing EBF practices in Semarang City. Methods: A quasi-experimental design involved 157 participants (98 mother-infant pairs and 49 peers) recruited from various public health centres from December 2023 to June 2024. The Kaplan-Meier survival curve, in conjunction with the log-rank test, was employed to assess the disparities in survival and the observed practices of EBF. The determinants of EBF duration were found using the cox proportional hazard ratio. Results: The …


Painting Rich Six-Dimensional Pictures Using Polarized Fluorescence Microscopy, Matthew D. Lew Mar 2025

Painting Rich Six-Dimensional Pictures Using Polarized Fluorescence Microscopy, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

No abstract provided.


Liver Tet1 Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease, Hongze Chen, Muhammad Azhar Nisar, Joud Mulla, Xinjian Li, Kevin Cao, Shaolei Lu, Katsuya Nagaoka, Shang Wu, Peng Sheng Ting, Tung Sung Tseng, Hui Yi Lin, Xiao Ming Yin, Wenke Feng, Zhijin Wu, Zhixiang Cheng, William Mueller, Amalia Bay, Layla Schechner, Xuewei Bai, Chiung Kuei Huang Mar 2025

Liver Tet1 Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease, Hongze Chen, Muhammad Azhar Nisar, Joud Mulla, Xinjian Li, Kevin Cao, Shaolei Lu, Katsuya Nagaoka, Shang Wu, Peng Sheng Ting, Tung Sung Tseng, Hui Yi Lin, Xiao Ming Yin, Wenke Feng, Zhijin Wu, Zhixiang Cheng, William Mueller, Amalia Bay, Layla Schechner, Xuewei Bai, Chiung Kuei Huang

School of Public Health Faculty Publications

Global hepatic DNA methylation change has been linked to human patients with metabolic dysfunction-associated steatotic liver disease (MASLD). DNA demethylation is regulated by the TET family proteins, whose enzymatic activities require 2-oxoglutarate (2-OG) and iron that both are elevated in human MASLD patients. We aimed to investigate liver TET1 in MASLD progression. Depleting TET1 using two different strategies substantially alleviated MASLD progression. Knockout (KO) of TET1 slightly improved diet induced obesity and glucose homeostasis. Intriguingly, hepatic cholesterols, triglycerides, and CD36 were significantly decreased upon TET1 depletion. Consistently, liver specific TET1 KO led to improvement of MASLD progression. Mechanistically, TET1 promoted …


The Prillwitz Mammoth: Taxonomy, Sex, Age, & Delayed Skeletal Maturation Of A Geologically Young Mammoth, Anna Rybachek Mar 2025

The Prillwitz Mammoth: Taxonomy, Sex, Age, & Delayed Skeletal Maturation Of A Geologically Young Mammoth, Anna Rybachek

Honors Theses

The Prillwitz mammoth, a nearly complete mammoth skeleton found in Southwest Michigan in 1962, is one of the geologically youngest mammoths from North America (AMS C-14 date: 11,300 ± 100 BP). Bones are well preserved; some long bones show post-mortem flaking, scratches, or grooves of unknown origin. All long-bone epiphyses remain unfused except the distal humerus, suggesting it was < 28 years old at death. In contrast, the skull and mandible preserve M3s and m3s, respectively, that are in mid-wear, indicating an Asian Elephant Year dental age of ~45-50 years. Long bone size and inferred shoulder height are consistent with the size of a large woolly mammoth (Mammuthus primigenius) or small to mid-sized Columbian mammoth (Mammuthus columbi), but dental evidence is most consistent with M. columbi.

Pelvic dimensions suggest it is a male. The ≥ 17-year mismatch between age inferred from tooth progression and wear (~45 Asian Elephant Years) and age inferred from epiphyseal fusion (< ~28 Asian EY if male) may indicate either substantially accelerated dental progression or delayed skeletal maturation for this mammoth; we deem the latter more likely. Based on modern analogs, delayed maturation could have been due to severe malnutrition, hormonal imbalance, illness, or genetic factors. Given the geologically young age of the Prillwitz mammoth (likely near the time of mammoth extinction), we speculate that delayed skeletal maturation may have been attributed to environmental stressors near the end of the Pleistocene. Further work is warranted on very late mammoths.


Development And Validation Of A New Formula To Predict Standard Pancreas Volume In Chinese Adults Using Body Surface Area, Domenech Asbun Mar 2025

Development And Validation Of A New Formula To Predict Standard Pancreas Volume In Chinese Adults Using Body Surface Area, Domenech Asbun

All Publications

Background: Changes in pancreas volume have been reported in many disorders. In clinical practice, pre-disease total pancreas volume (TPV) is often unavailable for patients with pancreatic pathologies (e.g., tumors, cysts, or pancreatitis), as prior imaging may not exist or may reflect abnormal volumes. While three-dimensional (3D) computed tomography (CT) reconstruction provides accurate TPV measurements, its utility is limited in these scenarios, necessitating a predictive formula. However, no widely clinically accepted standard pancreas volume (SPV) formula currently exists. This study aims to develop an SPV prediction formula based on 3D CT reconstruction and the characteristics of Chinese adults.

Methods: The TPV …


The Impact Of Art In Medicine Training And Its Effectiveness On Professionalism And Interpersonal Skills: A Prospective Study., Maria Musri, Atif Nehvi, Shireen Chacko, Glenn Eiger, Nazanin Moghbeli Mar 2025

The Impact Of Art In Medicine Training And Its Effectiveness On Professionalism And Interpersonal Skills: A Prospective Study., Maria Musri, Atif Nehvi, Shireen Chacko, Glenn Eiger, Nazanin Moghbeli

Einstein Health Papers

INTRODUCTION: Internal Medicine residents in The United States of America (USA) need to demonstrate competency in the Accreditation Council for Graduate Medical Education (ACGME) core areas to meet training requirements. Two of these core competencies are professionalism and interpersonal/communication skills. Medical humanities can positively influence trainee development by cultivating these skills. There is limited literature on the use of art-based programs to enhance communication and professionalism skills among residents aside from the original FRAME workshop. We have designed a six-part series called "Using Art for Professionalism and Communication Skills in Medical Education" (UAPCMedEd) that implements visual arts training strategies to …


Lonza Leadership Visits Unh's Tissue Culture Lab, Keith Testa Mar 2025

Lonza Leadership Visits Unh's Tissue Culture Lab, Keith Testa

UNH Today Archive

No abstract provided.


Reweighting Configurations Generated By Transferable, Machine Learned Models For Protein Sidechain Backmapping, Jacob Monroe Mar 2025

Reweighting Configurations Generated By Transferable, Machine Learned Models For Protein Sidechain Backmapping, Jacob Monroe

Chemical Engineering Faculty Publications and Presentations

Multiscale modeling requires the linking of models at different levels of detail, with the goal of gaining accelerations from lower fidelity models while recovering fine details from higher resolution models. Communication across resolutions is particularly important in modeling soft matter, where tight couplings exist between molecular-level details and mesoscale structures. While multiscale modeling of biomolecules has become a critical component in exploring their structure and self-assembly, backmapping from coarse-grained to fine-grained, or atomistic, representations presents a challenge, despite recent advances through machine learning. A major hurdle, especially for strategies utilizing machine learning, is that backmappings can only approximately recover the …


Quo Vadis Hak Atas Kesehatan Reproduksi: Analisis Rekonstruksi Pengaturan Aborsi Di Indonesia (Perbandingan Hukum Indonesia Dengan Perancis), Dian Kencana Putri, Erna Dyah Kusumawati Mar 2025

Quo Vadis Hak Atas Kesehatan Reproduksi: Analisis Rekonstruksi Pengaturan Aborsi Di Indonesia (Perbandingan Hukum Indonesia Dengan Perancis), Dian Kencana Putri, Erna Dyah Kusumawati

Jurnal Hukum & Pembangunan

Pembatasan akses aborsi di Indonesia menyebabkan banyak perempuan dengan kehamilan tidak diinginkan terpaksa berhadapan dengan hukum. Pembatasan aborsi yang mengakibatkan kriminalisasi ini dapat menyebabkan dilema moral bagi banyak perempuan yang mengalami kehamilan tidak diinginkan. Padahal aborsi berpotensi terjadi pada setiap perempuan berusia produktif di Indonesia. Aborsi di Indonesia merupakan tindakan ilegal dan aborsi hanya dapat dilakukan dalam dua kondisi saja, yakni kedaruratan medis dan kehamilan yang disebabkan perkosaan. Artikel ini menganalisa bagaimana sebenarnya substansi aborsi dapat dimasukkan pada kategori hak kesehatan reproduksi perempuan dan mengapa negara Indonesia perlu mengubah kebijakan dan hukum mengenai aborsi. Untuk melihat seberapa pentingnya negara harus …


Unveiling The Transformative Power Of Unsupervised Machine Learning Through Clustering, Vishnu S. Pendyala Mar 2025

Unveiling The Transformative Power Of Unsupervised Machine Learning Through Clustering, Vishnu S. Pendyala

Open Educational Resources

Clustering methods demonstrated their transformative potential across various industries through image segmentation, anomaly detection, bioinformatics, and customer segmentation. The presentation explores these techniques in unsupervised machine learning, focusing on foundational clustering algorithms such as K-means, Hierarchical Clustering, and DBSCAN. Through an in-depth analysis of their underlying principles and computational intricacies, the presentation highlights how these methods have evolved to address complex, high-dimensional data problems. The presentation provides insights into how K-means remains a versatile tool for partitioning data in linear spaces. It delves into Hierarchical Clustering's unique approach to building dendrograms and capturing multi-scale data relationships, and how DBSCAN's density-based …


Evaluation Of Gfap And Ptau Protein Expression In Male And Female Cci Mouse Models, Sara Wallace Mar 2025

Evaluation Of Gfap And Ptau Protein Expression In Male And Female Cci Mouse Models, Sara Wallace

Honors Program: Senior Projects (Public)

Traumatic Brain Injury (TBI) is a serious public health concern that leads to the death or disability of thousands of individuals in the US annually. Progression of TBI involves primary damage from the initial, mechanical injury and secondary damage, from nonmechanical, pathological dysfunction. The secondary damage mechanisms can be better understood, diagnosed, and treated through the quantification of TBI biomarkers. The two biomarkers of interest in this study are pTau and GFAP. The male and female mouse models showed similar significant increase in GFAP following injury, as well as a general lack of increase in pTau expression following the injury. …


Tucatinib And Trastuzumab In Her2-Mutated Metastatic Breast Cancer: A Phase 2 Basket Trial., Okines Afc, G Curigliano, N Mizuno, Oh Dy, A Rorive, H Soliman, S Takahashi, T Bekaii-Saab, Burkard Me, Chung Ky, Debruyne Pr, Fox Jr, V Gambardella, Pohlmann Pr Mar 2025

Tucatinib And Trastuzumab In Her2-Mutated Metastatic Breast Cancer: A Phase 2 Basket Trial., Okines Afc, G Curigliano, N Mizuno, Oh Dy, A Rorive, H Soliman, S Takahashi, T Bekaii-Saab, Burkard Me, Chung Ky, Debruyne Pr, Fox Jr, V Gambardella, Pohlmann Pr

School of Nursing and Midwifery

Human epidermal growth factor receptor 2 (HER2, also known as ERBB2) signaling promotes cell growth and differentiation, and is overexpressed in several tumor types, including breast, gastric and colorectal cancer. HER2-targeted therapies have shown clinical activity against these tumor types, resulting in regulatory approvals. However, the efficacy of HER2 therapies in tumors with HER2 mutations has not been widely investigated. SGNTUC-019 is an open-label, phase 2 basket study evaluating tucatinib, a HER2-targeted tyrosine kinase inhibitor, in combination with trastuzumab in patients with HER2-altered solid tumors. The study included a cohort of 31 heavily pretreated female patients with HER2-mutated metastatic breast …


Galectin-1 Inhibition As A Strategy For Malignant Peripheral Nerve Sheath Tumor Treatment, Hsiao-Chi Wang, Keila E Torres, Roger Xia, Marcio H Malogolowkin, Ssu-Wei Hsu, Ching-Hsien Chen, Tsung-Chieh Shih Mar 2025

Galectin-1 Inhibition As A Strategy For Malignant Peripheral Nerve Sheath Tumor Treatment, Hsiao-Chi Wang, Keila E Torres, Roger Xia, Marcio H Malogolowkin, Ssu-Wei Hsu, Ching-Hsien Chen, Tsung-Chieh Shih

Faculty, Staff and Student Publications

Neurofibromatosis type 1 (NF1) is an inherited disorder that predisposes individuals to malignant peripheral nerve sheath tumors (MPNSTs), a highly aggressive sarcoma with limited treatment options and poor prognosis. This study explores the potential of targeting the interaction between Galectin-1 and Ras as a novel therapeutic strategy for MPNSTs. Through molecular docking, we identified critical residues involved in the Galectin-1 and H-Ras interaction. We developed LLS30, a compound designed to target this Ras-binding pocket on Galectin-1, and tested its efficacy. LLS30 effectively disrupted the Galectin-1/Ras interaction, causing Ras delocalization from the plasma membrane and inhibiting Ras signaling. In vitro experiments …


Lanthorn, Vol. 59, No. 14, March 31, 2025, Grand Valley State University Mar 2025

Lanthorn, Vol. 59, No. 14, March 31, 2025, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.