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Correlates Of Suicide And Temporal Variations In Subjects With Suicide Attempt, Bandna Gupta, Prashant Choudhary, Adarsh Tripathi, Anil Nischal, Manu Agarwal

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Suicide Attempt is a self-inflicted, potentially injurious behavior with a nonfatal outcome for which there was evidence of intent to die. Life changes could act as a stressor causing enhanced susceptibility for suicidal risk. Suicide is a complex public health problem due to interactive social, cultural, biological and psychological risk factors.

AIM:

To study suicide intent and it's association stressful life events in subjects with suicide attempt.

MATERIAL AND METHODS:

The study was cross-sectional, non-interventional study which included 102 patients. Semi-structured Performa including socio-demographic and clinical history details, Presumptive Stressful Life Events Scale (PSLES) [Singh

et al

., 1984] …

Utility Of C4d Deposits In Native Renal Diseases And Relation With Disease Progression, Sucheta Yadav, Atin Singhai, Suresh Babu, Vijay Kumar Singh, Anupam Wakhlu, Satyendra Sonkar, Bhupendra Pal Singh, Chanchal Rana

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

C4D is a well-known biomarker of complement cascade. The utility of C4D in identification of antibody-mediated rejection has been known since its incorporation in Banff classification in 2003. Recently, many researchers have turned their attention to C4D deposition in native renal diseases. The present study was done at our tertiary care center to adjudge the significance of C4D deposits in native renal diseases across Indian cohort of patients.

MATERIALS AND METHODS:

A retrospective study was done on fifty cases of native renal diseases and followed up at 6 months. C4D immunohistochemical analysis was performed on formalin-fixed paraffin-embedded renal tissue …

Design, Synthesis, And Biological Evaluation Of Novel Diclofenac Analogs As Promising Anti-Inflammatory Agents, Manjula K. Chikkamath, Girish A. Hampannavar, Mahesh B. Palkar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesics and antipyretics in the treatment of pain, fever, and rheumatoid arthritis. Major side effect with treatment of NSAIDs is gastric irritation. 1,3,4-thiadiazole is an imperative scaffold since several of these derivatives are known to be associated with multiple biological activities such as anti-inflammatory, antibacterial, anti-cancer, anti-tubercular, and immunosuppressive. Literature survey reveals that certain compounds bearing this nucleus possess significant anti-inflammatory activity with reduced ulcerogenic effect.

MATERIALS AND METHODS:

In the present research work, we have synthesized thirteen 2-(2-[2,6-dichlorophenylamino] phenyl) acetohydrazide derivatives (4a–4m) and four 2,6-dichloro-

N

-(2-[6-phenylimidazo[2,1-b][1,3,4]thiadiazol-yl] methyl] phenyl) benzenamine …

Excessive Gestational Weight Retention And Weight Gain In Postpartum Perception Of Women, Thilagavathy Ganapathy

Indian Journal of Health Sciences and Biomedical Research KLEU

CONTEXT:

Childbearing women are the second victims for significant gestational weight retention and weight gain during reproductive years. There may be unique reasons to weight management in this period.

AIM:

To explore what women perceive as reasons for their excessive gestational weight retention and weight gain in the postpartum period.

METHODS:

By purposive sampling,

n

= 200 low-risk postnatal women less than a year of postpartum were recruited and their perceived reasons for excessive gestational weight retention and weight gain in the postpartum period were assessed.

RESULTS:

Participants perceived lowered physical activity, sedentary lifestyle behavior, lack of knowledge, misconceptions that …

Do Noise Stress Impact To Addiction?, Sundareswaran Lognathan, Arbind Kumar Choudhary, Kuppusamy Mahesh Kumar

Indian Journal of Health Sciences and Biomedical Research KLEU

Numerous studies have illustrated the impact of stress on addiction, its development, relapse vulnerability, and the dopamine mechanism. However, various studies on noise exposures as a stressor had been done, which could alter the hypothalamic–pituitary–adrenal (HPA) axis. Noise exposure harmful effect and changes in the individual's health was at least consideration and were less noticed. This review elucidates the facts and consequences of noise exposure toward mesolimbic dopamine circuitry perceptible in addiction. Further, this review generates greater attention and awareness among people toward noise exposure influence on addiction and its relation with dopamine. The noise stress may act as a …

A Rare Variety Of Pulmonary Blastoma A Case Report And Review Of Literature, L. Purnima Devi, Umesh Das, Rintu Marak, Jyoti Prasad Kalita, Yookarin Khongla, Baphirayne Wankhar, Ibanylla Meggsi Pala Rymbai

Indian Journal of Health Sciences and Biomedical Research KLEU

Pulmonary blastoma (PB) is a very rare primary lung neoplasm. Morphologically, they mimic fetal lung tissue before 4 months gestation. As monophasic variety is extremely rare, we have reported here a case of monophasic PB in a young adult patient who came with cough and hemoptysis for 4 months. On computed tomography scan of the chest, findings showed left upper lobe mass with few specks of calcification within the lesion. The patient underwent left upper lobectomy. The diagnosis was confirmed through histopathological examination with immunohistochemical evaluation. Because of its extreme rarity, we report this case with special interest to help …

Gnathic Osteosarcoma An Analysis Of A Single-Institutional Experience, Adebayo Aremu Ibikunle, Abdurrazaq Olanrewaju Taiwo, Ramat Oyebunmi Braimah, Kabir Abdullahi, Michael Adeyemi, Malami A. Usman

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Osteosarcoma is an aggressive primary bone malignancy characterized by osteoid formation. It typically affects long bones, rarely affecting the jaws. OS of the jaws accounts has an estimated incidence of 0.7 per million. Reports of gnathic osteosarcoma from sub-Saharan Africa are few and to the best of our knowledge there is none from Northwestern Nigeria. This study aims to present our experience with gnathic osteosarcoma in our center.

MATERIALS AND METHODS:

A review of the records of patients managed on account of histologically diagnosed gnathic osteosarcoma at the Department of Dental and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, …

A Community-Based Study On Nasal Carriage Of Staphylococcus Aureus Among Healthy Schoolchildren And Its Antimicrobial Susceptibility Pattern, Ranjeeta, Sumati A. Hogade

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Invasive infections from

Staphylococcus aureus

are increasingly being encountered in healthy children. Nasal colonization of

S. aureus

is associated with increased risk for acquiring invasive disease. The objective of this study was to determine the prevalence and risk factors for

S. aureus

nasal colonization among a healthy pediatric population and to determine antibiotic susceptibilities of the

S. aureus

isolates.

MATERIALS AND METHODS:

Using a cross-sectional study design, a total of 468 children of age group 5–16 years from 15 different schools of urban Belgaum (Belagavi) located under Ramnagar Urban Health Centre of KLE University's Jawaharlal Nehru Medical College, India, …

A Study On Safe Driving Performance Using Biofeedback Therapy Among Drivers In Delhi, Neelima Chakrabarty, Kumar Sumit, Kamini Gupta

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Biofeedback therapy is essential for releasing the stress, gain awareness, and to control over psychophysiological processes. The current study deals with the impact of biofeedback therapy on drivers by comparing the performances of drivers on “Decision Time” (DT) test before and after the use of biofeedback therapy.

METHODOLOGY:

For this study, as a special case 40 drivers from special protection group were selected for administering the decision time (DT) from “Vienna Test System” before and after applying biofeedback therapy with respiratory training.

RESULTS:

The results of this study reveal the beneficial effects of biofeedback in reducing negative effects, thereby …

Probiotic Use In The Management Of Hypertension A New Era Of Therapeutic Management, Swapnil Purushottam Borse, Devendra Pratap Singh, Dilawar Upadhyay, Vipin Sharma, Manish A. Nivsarkar

Indian Journal of Health Sciences and Biomedical Research KLEU

Hypertension (HTN) has become a common chronic medical condition which affects ≥20% of adult population worldwide. HTN is assumed to be a major contributing factor for increasing complication of metabolic syndrome by adding one or more comorbidities such as heart disease, stroke, chronic renal failure, myocardial infarction, blindness, and dementia. HTN is also considered as a lifestyle disorder, and there are mainly two types of HTN, namely primary and secondary. Primary HTN is about 90%–95% of all cases of HTN and it is defined as high blood pressure due to genetic factors and nonspecific lifestyle, while secondary HTN is due …

Global Research Trends Of Literature In Sugar-Sweetened Beverages 2000–2016, Waleed M. Sweileh, Ansam F. Sawalha, Samah W. Al-Jabi, Saed H. Zyoud, Adham S. Abutaha

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Sugar-sweetened beverages (SSBs) are commonly used. The objective of this study was to analyze the quantity and quality of published literature on SSBs and present the results in a bibliometric format.

METHODOLOGY:

Scopus database was used to retrieve documents from 2000 to 2015. Annual growth of publications, collaborations, geographic distribution, visualization and mapping of collaboration, author analysis, and top-cited articles will be presented and discussed.

RESULTS:

The total number of worldwide publications on SSBs was 3345, published in 27 subject areas. More than half (58.30%) of the SSB publications were within the area of medicine. The number of publications …

To Evaluate The Effect Of Probiotics On The Prevalence Of Oral Candida Organisms In Denture Wearers An, Deepali Jagadeesh Rane, Ramesh Nayakar, Sheetal Harakuni, Raghunath Patil

Indian Journal of Health Sciences and Biomedical Research KLEU

STATEMENT OF PROBLEM:

Candida

species are the major human fungal pathogens that cause both mucosal and deep-tissue infections. Fungal infections have been successfully treated by systemic antifungal agents for a very long time. The toxicity of available antifungals and resistance to these drugs are a concern; thus, the use of probiotics has emerged as an alternative therapeutic technique for treating

Candida

infections.

PURPOSE:

The purpose of this study was to evaluate the effect of probiotics on the prevalence of oral

Candida

organisms in denture wearers with different age groups.

MATERIALS AND METHODS:

Sixty completely edentulous denture wearers were divided into …

Necessity To Invest In Research And Development Activities To Combat The Threat Of Antimicrobial Resistance World Health Organization, Saurabh Rambiharilal Shrivastava, Prateek Saurabh Shrivastava, Jegadeesh Ramasamy

Indian Journal of Health Sciences and Biomedical Research KLEU

No abstract provided.

A Study To Evaluate Cardiovascular Responses By Using Treadmill And Ergometer Bicycle Exercise In Young Adults, Alok Kumar Yadav, Jayasheela G. Bagi

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND AND OBJECTIVE:

Exercise is inevitable to keep good health status, advised for health promotion, diagnosis of diseases, and rehabilitation. Different types of exercise are performed as exercise tolerance, but tolerance is not same for every individual. Thus, the objective of this study is to evaluate the cardiovascular responses for three different intensities of exercise using treadmill and bicycle ergometer at fixed heart rate (HR) value in young healthy adults.

METHODS:

After obtaining the ethical clearance from the Institutional Ethical Committee, a total of 130 participants were screened and 48 randomly selected male and female individuals with age group of …

Two-Dimensional-Quantitative Structure-Activity Relationship Studies Of A Novel Series Of Diaryl Furanone Derivatives An Approach To Design Selective And Effective Cyclooxygenase-2 Inhibitors, Manjula K. Chikkamath, Pratibha M. Huded, Swetha S. Kokatnur, Akshata S. Menasinakai, Mahesh B. Palkar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Over a decade, a large number of selective cyclooxygenase-2 (COX-2) inhibitors with diverse chemical characteristics have been designed but only a few have emerged as drugs.

MATERIALS AND METHODS:

In the present study, two-dimensional-quantitative structure-activity relationship (2D-QSAR) studies were performed on a set of 43 novel derivatives of diaryl furanone using V-Life Molecular Design Suite (MDS 3.5) QSAR plus module using multiple linear regression (MLR) and Partial Least Square (PLS) regression methods against a COX-2 enzyme.

RESULTS AND DISCUSSION:

PLS method has displayed a very significant prediction results. QSAR model was generated by a training set of 33 molecules …

Comparison Of Vitamin “C” Levels In Naturally Ripened And Artificially Ripened Mangoes, Jayashree Neelakantha Majagi, Vanishree Basavraj Jabannavar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Fruits are very good sources of micronutrients. In the present era, eating fruits is questionable due to hazardous effects of artificial ripener usage on fruits. Ascorbic acid (C

6

H

8

O

6

), a major antioxidant water-soluble vitamin, acts as a reducing agent for many metabolic reactions as a coenzyme. Since it is heat-labile, fruits remain as a prime source as they are eaten uncooked. Mangoes, Banana, and Papaya are the most commonly subjected fruits for artificial ripening. However, artificial ripeners such as ethephon and calcium carbide have antinutritional and hazardous effects on health. This study analyzed the …

Expression Of Estrogen Receptor, Progesterone Receptor, And Human Epidermal Growth Factor Receptor Type 2/Neu In Surface Epithelial Ovarian Tumors And Its Clinicohistopathological Correlation, Neeta Verma, Madhu Kumar, Mala Sagar, Suresh Babu, Atin Singhai, Nisha Singh, Sujata Dev, Vijay Kumar

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Ovarian cancers represent the 4

th

most frequent type of cancers among females and are the most common cause of death from gynecological cancers in the world.

AIMS AND OBJECTIVES:

The aim is to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2/neu) immunohistochemical markers in surface epithelial ovarian tumors and its clinicopathological correlation with CA-125 level, histological type, grading of tumors, and prognosis of ovarian tumors.

MATERIALS AND METHODS:

This study included 48 cases of surface epithelial ovarian tumors including serous, mucinous, and adenocarcinoma Not Otherwise Specified (NOS). After grossing …

Review Of Selected Herbal Phytoconstituents For Potential Melanoma Treatment, Bhaskar Kallappa Kurangi, Sunil Satyappa Jalalpure

Indian Journal of Health Sciences and Biomedical Research KLEU

Malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. The current chemotherapies have a relatively low success rate due to the development of multidrug resistance and side effects. Hence, there is need of discovering new compounds that are safe and more effective against melanoma to improve the efficiency and to lower the treatment cost for cancer care. Melanoma chemoprevention with natural herbal phytoconstituents is an emerging strategy to prevent, cure, or treat melanoma. This review summarizes the latest research in melanoma chemoprevention and treatment using the herbal phytoconstituents. Relevant mechanisms involved in the pharmacological …

Effect Of, Aryaa A. Ankalikar, A. H. M. Viswanathswamy

Indian Journal of Health Sciences and Biomedical Research KLEU

Context:

Phytochemical investigations of hydroalcoholic extracts of

Vitex trifolia

Linn and

Solanum nigrum

Linn suggest the presence of flavonoids, terpenoids, and steroids and have been traditionally claimed to be useful in the treatment of inflammation, fever, edema, and tuberculosis.

Aim:

In the present study, hydroalcoholic extract of the plants was evaluated for its free radical scavenging capacity against hydroxyl, hydrogen peroxide, and nitric oxide radicals, and it's

in vitro

anti-inflammatory potential.

Materials and Methods:

Hydroalcoholic extracts of

V. trifolia

L. and

S. nigrum

L. were studied at different concentrations for their scavenging ability against free radicals and their ability to …

A Cross-Sectional Study Of P53 Expression In Patients With Squamous Cell Carcinoma Cervix A Hospital-Based Study, Niharika Singh, Hema Bannur

Indian Journal of Health Sciences and Biomedical Research KLEU

Context:

Cervical cancer is the second most common cancer in women in India and the fourth most common cancer in women worldwide. The p53 is a tumor suppressor gene. Overexpression of p53 is detected by immunohistochemistry (IHC) and it indicates a worsened prognosis in some malignancies.

Aims:

The present study was undertaken to assess the expression of p53 by IHC in normal cervical epithelium and squamous cell carcinoma (SCC) cervix. The role of p53 as a potential biomarker by correlating p53 expression with clinico-pathological parameters was also studied.

Settings and Design:

Cross-sectional study.

Subjects and Methods:

A total of 50 …

Comparative Evaluation Of The Effect Of Commercially Available Two Different Forms Of Denture Cleansers On Denture Biofilm In Diabetic And Nondiabetic Individuals An, Heena Sharma, Raghunath Patil, Jyoti M. Nagmoti

Indian Journal of Health Sciences and Biomedical Research KLEU

Statement of Problem:

Denture cleansers are known to decrease the microbial counts in denture wearers. In certain medical conditions such as in diabetes, achieving reduction in microbial count and maintaining proper denture hygiene is difficult. Denture cleansers are used as an aid in maintaining denture hygiene in such patients. A number of tablets, pastes, and powders are available for cleaning dentures. Although the comparison of chemical methods and brushing is relatively common, their difference in diabetic denture biofilm and nondiabetic denture biofilm has not been previously described.

Purpose:

The purpose of this study was to investigate the effect of commercially …

“Evaluation Of Wound Healing And Bone Regeneration Using Autologous Platelet-Rich Plasma And Platelet-Rich Fibrin Postextractions” A Comparative Study, Niyati Satish Balse, Shridhar Baliga

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

It has already been established in the past that platelets play a major role in wound healing. Platelet- rich plasma (PRP) and Platelet- rich fibrin (PRF) are autologous concentrates of platelets in a relatively small volume of plasma and they enable delivery of growth factors in increased amounts to surgical sites to promote wound healing.

Aims and Objectives:

This study focuses on comparing the two platelet concentrates – platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) as graft materials in extraction sockets and their efficacy in wound healing and bone regeneration.

Materials and Methods:

Sixty patients requiring extraction of unilateral …

Effect Of Storage And Temperature On Two Biochemical Analytes (Creatinine And Urea) In Pooled Serum Samples Stored At -20°C, Nilesha Vilas Vernekar, Vanishree Basavraj Jabannavar

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Creatinine and urea are nonprotein nitrogenous compounds which are eliminated from the body. Creatinine is a word obtained from a Greek term "Kreas" meaning flesh. An anhydrous form of creatine is creatinine. Around 0.5% of total muscle weight constitutes creatine. Muscle, brain, blood, etc., are the tissues, in which creatinine is present as high-energy compound, phosphocreatine, and creatine as free compound. Optimal storage of serum specimens in biobanks for long time for multicenter reference interval studies remains to be determined. Hence, in this context, the present study was undertaken to determine the effect of storage time and temperature on …

Correlation Of Serum Albumin With Ischemia Modified Albumin In Acute Stroke Patients With Or Without Diabetes Mellitus, Jayaraj G. Gudi, Anil Malleshappa, Karkal Ravishankar Naik

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Stroke is the leading cause of mortality and morbidity worldwide. Diabetes mellitus (DM) is most commonly associated with the acute stroke. Abnormalities in serum albumin are known to occur in acute stroke patients. Ischemia-modified albumin (IMA) is a novel marker of acute stroke and hence, it is important to know the factors affecting IMA estimation. The objective of this study was to find out the correlation between serum albumin and IMA in acute stroke with or without DM.

Subjects and Methods:

This cross-sectional study comprised sixty acute stroke patients (thirty with DM, thirty without DM) and thirty healthy controls. …

Cardioprotective Effect Of, M. Santosh Kumar, Viswanatha Swamy Mallinathaiah Agadi Hiremath

Indian Journal of Health Sciences and Biomedical Research KLEU

Objective:

The present study was designed to evaluate the cardioprotective potential of

Acorus calamus

(AC) on doxorubicin (DOX)-induced myocardial toxicity.

Materials and Methods:

Albino Wistar rats were used in this study. DOX was administered intraperitoneally in six equal injections (each containing 2.5 mg/kg DOX at 48 h interval) to a total cumulative dose of 15 mg/kg over 2 weeks to produce cardiotoxicity. Control and treated group animals were used for the estimation of lipid and cardiac biomarkers. Animals were sacrificed and heart tissue was used for the assay of glutathione (GSH), malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD) and …

Evaluation Of Salivary Nitric Oxide Levels In Caries-Free Children And Children With Early Childhood Caries An, Harsha Gope Assudani, Shivayogi M. Hugar, Anuradha Patil, Suma H. P. Sogi, Neha S. Dhariwal, Prachi Thakkar

Indian Journal of Health Sciences and Biomedical Research KLEU

Background and Objectives:

Early childhood caries (ECC) is one of the most prevalent diseases of childhood. Pediatric dentists must make conscious efforts to prevent this condition for optimal oral health. Normal salivary function is considered critical for the maintenance of a healthy oral cavity. Saliva provides an easily available, noninvasive medium for the diagnosis of wide range of diseases and clinical conditions. The objective of the present study was to estimate and compare salivary nitric oxide (NO) levels in caries-free children and children with ECC.

Methodology:

The children were divided into two groups. Group I comprised thirty caries-free children and …

Comparative Evaluation Of The Most Reliable Posterior Reference Point Of Camper′S Plane In Relation With Hamular Notch-Incisive Papilla Plane With Change In Gender Of Edentulous Subjects A Cephalometric Study, Kirandeep Kaur, Santosh Y. Nelogi, Raghunath Patil

Indian Journal of Health Sciences and Biomedical Research KLEU

Statement of the Problem:

Camper's plane is widely used to orient occlusal plane in edentulous patients, but the most reliable posterior reference point of Camper's plane is controversial.

Purpose:

The purpose of this study was to evaluate the most reliable posterior reference point of Camper's plane in relation with hamular notch-incisive papilla (HIP) plane with change in gender of edentulous subjects.

Materials and Methods:

The study was performed on 20 males and 20 females in the age group of 50-65 years. The conventional method of primary and secondary impression making was followed. The deepest point of the right hamular notch …

Evaluation Of Anticonvulsant Activity Of Polyherbal Formulation Based On Ayurvedic Formulation, Arka Ghosh, Ashish Mishra, Ankit Seth, Santosh Kumar Maurya

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

The aim of the present study was to develop a polyherbal formulation for epilepsy. Present polyherbal formulation (PHF) (containing

Operculina turpethum

(L.) Silva Manso,

Mimosa pudica

L.,

Uraria picta

(Jacq.) DC.,

Cajanus cajan

(L.) Millsp, and

Lawsonia inermis

L.) is based on an ayurvedic formulation "

Brihad Panchagavya Ghrita

" indicated for epilepsy.

Materials and Methods:

To establish the scientific basis of mechanism, we examined the effects of methanolic extract of PHF (100, 200, and 400 mg/kg, p.o.) on maximal electric shock (MES), pentylenetetrazol (PTZ), and isoniazid (INH)-induced convulsions as well as gamma-aminobutyric acid (GABA)-glutamate level in the brain …

Role Of, Bhrigu Kumar Das, Basavaraj C. Koti, Pramod C. Gadad

Indian Journal of Health Sciences and Biomedical Research KLEU

Objective:

This study aims to evaluate the role of

Lycopersicon

esculentum

in diethylnitrosamine (DEN)-induced and phenobarbital (PB)-promoted hepatocellular carcinoma.

Materials and Methods:

The hepatocarcinogenesis was induced in male Wistar albino rats by DEN (single injection, 200 mg/kg, i.p

.

); 2 weeks later, 0.05% w/v of PB was administered through drinking water for 16 weeks. The treatment group rats received a similar dosage as above along with enzymatic extract of

L.

esculentum

(250 mg/kg body weight p.o.) at 3

rd

week onward. The carcinogenesis was evaluated by estimating biochemical markers such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase …

An Overview On Sildenafil And Female Infertility, Jyoti M. Benni, Paragouda A. Patil

Indian Journal of Health Sciences and Biomedical Research KLEU

Endometrial thickness (EM) is one of the strongest predictors of implantation rate and ongoing pregnancy success rate. The endometrial growth is dependent on the uterine blood flow and angiogenesis. Recently, some reports discussed the possible beneficial effects of sildenafil citrate on EM. Sildenafil citrate leads to smooth muscle relaxation and vasodilation. Because of these biological properties, it is a potential candidate for female infertility, especially in the management of thin endometrium, which leads to low implantation and pregnancy rates. An updated electronic search was performed through PUBMED, MEDLINE, and COCHRANE and focused on peer-reviewed, randomized controlled trials, and observational cohort …