Digital Commons Network^™

Evaluating The Efficacy Of Venetoclax-Based Regimens In Relapsed/Refractory Acute Leukemia: A Real-World Study From Three Chinese Oncology Centers, Wei Zhang, Liyang Huang, Ming Zhao, Rui Chen, Huiwen Liu

Muthanna Medical Journal

Background: Relapsed or refractory (R/R) acute leukemia poses a significant therapeutic challenge, with limited options and poor prognosis. Venetoclax, a BCL-2 inhibitor, has shown promise in frontline acute myeloid leukemia (AML), but its real-world utility in R/R settings remains underexplored. Objective: To evaluate the efficacy and safety of venetoclax-based regimens in adult patients with R/R acute leukemia treated in routine clinical practice across three tertiary oncology centers in China. Methods: A retrospective multicenter study was conducted on 70 patients with R/R acute leukemia (AML or ALL) treated between January 2020 and December 2023. Patients received venetoclax combined …

Integrating Molecular Insights Into Treatment Strategies: The Pi3k/Akt/Mtor Axis In Hr+ Breast Cancer Management In India, Ananya Deshmukh, Raghavendra B. Iyer, Priyanka Nair, Vivek Sharma

Muthanna Medical Journal

Background: The PI3K/AKT/mTOR pathway plays a pivotal role in endocrine resistance among hormone receptor-positive (HR+) breast cancer patients. Despite growing global access to pathway-targeted therapies, the clinical integration of molecular diagnostics in India remains limited. This study investigates the prevalence and prognostic implications of PI3K/AKT/mTOR pathway activation in HR+ breast cancer using patient-derived tumor tissue. Methods: This prospective observational study analyzed tumor samples from 60 HR+ breast cancer patients treated at a tertiary oncology center in India. PIK3CA mutation status was assessed via PCR-based genomic testing. Protein expression of p-AKT and mTOR was evaluated using immunohistochemistry. Survival data …

The Frequency Of Hla-Dr4/Dr4 Type And Interleukin-35 Level Among Type 1 Diabetes Mellitus Patients In Al-Muthanna Governorate/Iraq, Salam Allawi Hassan, Orass Madhi Shaheed

Muthanna Medical Journal

Background: The autoimmune illness recognized as (T1DM) causes weight loss, polyuria, polydipsia, and hyperglycemia along with the progressive death of β-cells. The disease primarily affects children and adolescents. The HLA genes might production a significant part in predisposing to type 1 diabetes. Interleukin-35 as a fellow of the IL-12 family that affects of immune modulation in a number of diseases, for instance (T1D), inflammatory bowel illness, Graves' illness, rheumatoid arthritis. Aim of Study: This study aimed to investigate the frequency of HLA-DR4/DR4 type in type 1 diabetes (T1D) and evaluate of interleukin-35 Level in patients compared with healthy …

Cross-Section Study Of Iron Deficiency Anemia In A Group Of Adolescents: Frequency And Contributing Factors, Murtaza Hassan Hadi, Mostafa Abdalla Abdelkareem, Nasser Ghaly Yousif

Muthanna Medical Journal

Background: Iron deficiency anemia (IDA) remains a significant global health concern, particularly among adolescents. This study investigated the prevalence and contributing factors of IDA among adolescents at Al Hussain Teaching Hospital, addressing a critical knowledge gap in the Iraqi healthcare context. Methods: A cross-sectional study was conducted on 77 adolescent patients (ages 12-18 years) from October 01, 2024, to January 30, 2025. Data collection included hemoglobin levels, serum ferritin measurements, dietary iron intake assessment, and socioeconomic status evaluation. Statistical analysis employed descriptive statistics, chi-square tests for categorical variables, and multivariate analysis to identify contributing factors. Results: The …

Therapeutic Potential Of Bone Marrow-Derived Stem Cells In The Treatment Of Ewing Sarcoma: New Approach, Nasser Ghaly Yousif, Fadhil G. Alamran, Ahmed Altimimi

Muthanna Medical Journal

Background: Ewing Sarcoma is a challenging pediatric bone cancer with limited treatment options, particularly in advanced stages. Recent research has highlighted the potential of bone marrow-derived stem cells (BMSCs) as a novel therapeutic approach due to their tumor-targeting capabilities and ability to modulate the tumor microenvironment. Objective: This study aims to explore the therapeutic potential of BMSCs in the treatment of Ewing Sarcoma, focusing on innovative strategies that leverage their unique properties to enhance treatment efficacy and patient outcomes. Methods: This study involved a comprehensive review of the literature on BMSCs and their application in cancer therapy, …

Interdisciplinary Comparison Of Verb Complementation Patterns In Selected Nigerian University Course Textbooks: Insights From Humanities And Natural Sciences, Scholastica Chinyere Amadi

Journal of English and Applied Linguistics

This paper describes the variation in the distributions and use of verb complementation types and patterns in selected academic textbooks. The theoretical framework is Chomsky’s phrase structure grammar. The data, obtained from the first chapters, titled, ‘General introduction’ and ‘Atom and its structure’ of purposively selected English Studies and Physics textbooks, comprising 473 transitive verb phrases are manually analyzed. The findings reveal that three verb complementation types, mono-transitive, intensive, and complex-transitive, vary in patterns across the two textbooks with the mono-transitive V+NP and intensive V+NP patterns being dominant in English while the complex-transitive V+PP pattern dominates in Physics. The findings …

Endovascular Management For Refractory Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (Tips) Creation, Jacob Schneider

Graduate Medical Education Research Journal

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Ventricular Tachycardia Ablation In Patients With Valvular Heart Disease, Fouad Khalil

Graduate Medical Education Research Journal

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Chronic Immunosuppression May Increase The Risk Of Coronary Artery Perforation In Patients Undergoing Cto-Pci, Mina Bhatnagar

Graduate Medical Education Research Journal

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Health Disparities Among Patients Referred To Multidisciplinary Heart Failure Clinic: A Retrospective Analysis, Garima Bhandari

Graduate Medical Education Research Journal

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Improving Diagnostic Precision In Thyroid Pathology By Synergistic Use Of Ai And Molecular Markers, Sarah Azad

Graduate Medical Education Research Journal

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Double Trouble: Coexistence Of Hodgkin And Non-Hodgkin Lymphoma With Chronic Itp And Cryptic Brain Metastasis, Durva Masih

Graduate Medical Education Research Journal

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Characterizing Prostate Cancer Stage Migration And Subsequent Treatment Implications In The Psma Pet Era, Joseph Carmicheal

Graduate Medical Education Research Journal

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Red Blood Cell Transfusion Causes Brain Inflammation In Murine Pups With Phlebotomy Induced Anemia, Pramod Shrestha

Graduate Medical Education Research Journal

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Surgical Outcomes And Decision Making For Bicuspid Aortic Valve, Adam Larsen

Graduate Medical Education Research Journal

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Langerhans Cell Histiocytosis Masquerading As Refractory Intertriginous Rash, Nicole Wozny

Graduate Medical Education Research Journal

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Survey Of Current Clinical And Imaging Practices Amongst Regional Obstetric Providers In Nebraska: A Discussion Of Future Application Of Artificial Intelligence In Fetal Echocardiography, Farhath Sulthana

Graduate Medical Education Research Journal

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Carbon Efficiency Of Natural Organic Honey-Memristor Based Neuromorphic Computing, Harshvardhan Uppaluru, Zoe Templin, Shah Zayed Riam, Feng Zhao, Jinhui Wang

Electrical and Computer Engineering Faculty Research & Creative Works

Natural organic memristors manufactured using honey have exhibited promising synaptic behavior, offering notable advantages such as environmental sustainability, low production and disposal costs, non-volatile storage capabilities, and bio/CMOS compatibility. In this paper, experimental evaluations of honey-memristor based neuromorphic systems are reported with a focus on estimating their carbon footprint. First, manufacturing and testing of honey-memristors is briefly described. To suppress variations and improve accuracy, an optimization technique - parallel memristors is applied. Experimental results indicate that this optimization method significantly improves the device performance of up to. However, it also leads to higher energy consumption and a higher carbon footprint …

Magnetic Nanoparticles: Synthesis And Applications In Life Sciences, Kishore Chand, Erick Salvador Vasquez

Chemical and Materials Engineering Faculty Publications

Magnetic nanoparticles (MNPs) are multifunctional materials with superparamagnetic properties and tunable surface chemistries, making them valuable across diverse fields, such as biomedicine, environmental remediation, and agriculture. This review examines recent advancements in MNP synthesis, encompassing chemical, physical, and environmentally friendly methods while highlighting improvements in size, morphology, and composition control that enhance application-specific performance and environmental sustainability. The review discusses various architectures, including single-core, core–shell, hybrid composites, and stimuli–responsive systems, with an emphasis on their stability, scalability, and functionalization potential. In biomedical applications, MNPs show promise in targeted drug delivery, magnetic hyperthermia, and magnetic resonance imaging contrast enhancement, where biocompatibility, …

Vitamin D3 Toxicity-Induced Hypercalcemia In Staphylococcal Arthritis: A Focus On Il-6, Ali Jabbar Abd Al-Hussain Alkawaz, Maryam Sabah Naser, Ali Jalil Obaid, Zakaria M. Al-Ghazaly

Karbala International Journal of Modern Science

Background: Vitamin D3  over-supplementation can induce toxicity through the development of hypercalcemia and may disturb immune modulation. This study examines the relationship between hypercalcemia  resulting from Vitamin D3 Overdose and serum Interleukin-6 (IL-6) levels in patients diagnosed with staphylococcal arthritis.

Methods: Forty male patients (mean age: 31 years; range: 17–45 years) were enrolled from Dec. 2024 to Feb. 2025. Twenty cases of staphylococcal arthritis were compared with twenty healthy male controls. Serum concentrations of Vitamin D3, calcium, IL-6, and other biochemical markers (urea, creatinine, ESR, WBC, and potassium) were analyzed. Staphylococcus aureus was isolated from synovial fluid and confirmed using …

Pm Irras Studies Of Organized Molecular Films At A Gold Electrode Surface, Zhang-Fei Su, Ai-Cheng Chen, Jacek Lipkowski

Journal of Electrochemistry

This feature article illustrates the potential of polarization modulation infrared reflection absorption spectroscopy (PM IRRAS) to provide molecular-level information about the structure, orientation and conformation of constituents of thin films at electrode surfaces. PM IRRAS relies on the surface selection rules stating that the p-polarized IR beam is enhanced, while the s-polarized beam is attenuated at the metal surface. The difference between p- and s-polarized beams eliminates the background of the solvent and provides IR spectra at a single electrode potential. In contrast, two other popular in situ IR spectroscopic techniques, namely, subtractively normalized interfacial Fourier transform infrared spectroscopy (SNIFTIRS) …

Bite By Bite: How Ungulate Browsing Shapes North America's Forest Future, Darius Hardalau, Vladut Stefanescu, Mindaugas Bakševičius, Michael Manton, Charles Ruffner, Gediminas Brazaitis, Georgeta Ionescu, Ovidiu Ionescu

Aspen Bibliography

Ungulate browsing represents a contemporary issue for forest development, influencing forest regeneration, composition, and management practices across the world, especially in North America. This review synthesizes findings from 101 studies conducted between 1980 and 2025 to examine patterns of herbivory damage through browsing by moose, elk, white-tailed deer, black-tailed deer, and bison. Despite regional variation, high ungulate density consistently emerges as the primary factor driving browsing intensity and ecological and economic impact, leading to decreased social acceptance of coexistence with ungulates. This review highlights the selective suppression of palatable species such as balsam fir, red oak, and white cedar, leading …

Development Of Biodegradable Mg-1zn-0.5sc Alloy & Surface Treatment Through Laser Shock Peening And Evaluation Of Microstructure & Property Correlation For Orthopedic Implants, Parameshwari R

Theses and Dissertations

Magnesium (Mg) and its alloys are of much interest as promising third-generation bio-materials for bone implant applications; however, challenges remain for the alloy's mechanical integrity and bio-corrosion behaviour. Therefore, appropriate alloying elements and surface-modification techniques are required to overcome these limitations. Zinc (Zn) and Scandium (Sc) elements were found to have good biocompatibility and biodegradability; hence, they were selected as suitable alloying elements for magnesium.

This research work aims to enhance the mechanical integrity and bio-corrosion resistance behaviour of a novel Mg-1wt% Zn-0.5wt% Sc cast alloy by laser shock peening surface treatment with multiple passes (LSP-2 Pass and LSP-3 Pass). …

Ifi16 Mediates Deacetylation Of Kshv Chromatin Via Interaction With Nurd And Sin3a Co-Repressor Complexes, Anandita Ghosh, Bala Chandran, Arunava Roy

School of Medicine Faculty Publications

IFI16 is a well-characterized nuclear innate immune DNA sensor that detects foreign dsDNA, including herpesviral genomes, to activate the inflammasome and interferon pathways. Beyond immune signaling, IFI16 also functions as an antiviral restriction factor, promoting the silencing of invading viral genes through transcriptional and epigenetic mechanisms. We recently demonstrated another role of IFI16, in which it interacts with and recruits the class I histone deacetylases, HDAC1 and 2, to the KSHV latency protein LANA, modulating its acetylation and function. In this study, we asked whether these IFI16-HDAC1/2 interactions contribute to broader epigenetic regulation of the KSHV chromatin. Our findings reveal …

Framing Messages Toward Pro-Environmental Behavior: A Self-Determination Theory Perspective, Anna A. Mendiola, Ma. Regina M. Hechanova

Journal of Management for Global Sustainability

The urgency of environmental issues has led to increased efforts to encourage pro-environmental behavior that is motivationally self-determined. On the other hand, persuasive communication has been established as having the ability to increase pro-environmental behavior significantly. Currently, there is hardly any research that links the use of persuasive communication, motivational constructs of Self-Determination Theory (SDT), and pro-environmental behavior. An experiment was conducted on 420 university students utilizing messages framed in terms of addressing needs of autonomy, competence, and relatedness, the basic constructs of SDT. The results established the differential effect of these messages on motivation and pro-environmental behavior. In contrast …

Illuminating Two Secondary Schoolteachers’ Praxes On A ‘Terrain Of Freedom:’ Lessons For Teacher Education, Paul Tarc, Nicholas Ng-A-Fook, Tasha Ausman, Catherine James

Northwest Journal of Teacher Education

This paper attunes to the stated focus of this special issue—teacher subjectivities on a terrain of freedom—to consider the qualities, possibilities and limits of teachers’ praxes and development upon this ‘terrain.’ In response to the call, we explore three critical questions: 1) Where does the teacher’s freedom lie amidst required protocols and standardization?; 2) Can teachers transcend how they have been conceived and conditioned?; and 3) How can teachers engage in transformative development? Through a "poetics of teaching," inspired by Hansen (2004), we frame teaching as a curricular and pedagogical art form that melds interdisciplinary, intellectual, aesthetic, and …

Beyond Silence: A Review- Exploring Sensory Intelligence, Perception And Adaptive Behaviour In Plants, Taranisen Panda, Nirlipta Mishra, Shaik Rahimuddin, Bikram Pradhan, Rajballav Mohanty

Journal of Bioresource Management

Plants, traditionally viewed as passive organisms, exhibit sensory and adaptive abilities that challenge conventional notions of plant biology. All organisms evolve ways to sense and interact with their surroundings, and plants, although lacking eyes, ears, or brains, perceive the world in sophisticated ways. Despite lacking a nervous system and other features typically associated with animals, plants can see, smell, hear, feel, learn, remember, and act similarly to animals. This review examines how plants perceive and respond to their environment using mechanisms analogous to vision, hearing, smell, taste, and touch, adjusting their morphology, physiology, and phenotype accordingly. Drawing from plant physiology, …

Soil Degradation Of Solvent-Cast Pha Films Produced By Bacillus Tequilensis Pwf Using Waste Polyethylene Terephthalate (Pet), Rafeya Sohail, Rida Batool, Nazia Jamil

Journal of Bioresource Management

Polyhydroxyalkanoate (PHA) aliphatic polymers however efficiently biodegradable, still pose a contradiction with the principles of green chemistry. Use of bacterial strains capable of degrading synthetic plastics for the production of biopolymers i.e., PHAs may aid in reduction of plastic pollution. Bacterial strains PWA; Bacillus subtilis (MH142143), PWF; Bacillus tequilensis (MH142145), and PWG; Bacillus safensis (MH142146) were grown on waste shredded PET and PET flakes. Highest bioconversion of PET to PHA was observed using PET flakes. Strain PWF produced 40.47 % (0.815 g/L) and 31.80 % (0.626 g/L) PHA using PET flakes and shredded PET at 48 h, respectively. Whereas highest …

Wisdom Responses To Troubled Times: Healing Through Contemplative And Somatic Approaches, David Smith, Thomas Falkenberg, Remy Y.S. Low, David Chang, Åsa Jarskog, Jason Brown, Randy Persad, Anna Rumjahn, Charles Scott, Heesoon Bai

Journal of Contemplative and Holistic Education

Humanity is facing troubled times, as witnessed by increased polarization and division that are exploding into various forms of violence. Collectively, we are facing unprecedented ecological and environmental disasters. On campuses throughout North America, and closer to home, student anxiety, depression and other mental health issues are increasingly prevalent. The academic fields of contemplative inquiry and somatic studies, which highlight holistic approaches to education, are responding to these troubled times by showing how we can accomplish presence of mind, promote healing, and embrace the physical, intellectual, emotional, social, spiritual, and ecological dimensions of wellness.

Immune Thrombocytopenic Purpura Association With Epstein-Barr Virus, Amer Aldamouk, Bachr Masri, Ali Khan, Pulkita Uppal

Graduate Medical Education Research Journal

Immune thrombocytopenia (ITP), also referred to as idiopathic thrombocytopenic purpura, is an acquired form of thrombocytopenia caused by antibodies directed against platelet glycoproteins, particularly anti-GpIIb/IIIa antibodies. Epstein-Barr virus (EBV), a herpes virus infecting a large majority of the population before adulthood, has been implicated in various immune-mediated disorders, including ITP. In this report, we present a case of a young adult female with a history of thrombocytopenia who was found to have severe thrombocytopenia attributed to chronic EBV infection. Despite initial treatment with corticosteroids and intravenous immunoglobulin (IVIG), the patient's condition necessitated second-line therapies, including rituximab and thrombopoietin receptor agonists. …