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Articles 11641 - 11670 of 31628
Full-Text Articles in Entire DC Network
Deprivation And Threat As Predictors Of Executive Functioning And Emotion Regulation In Early Adolescence: The Protective Role Of School Support, Abigail Best De Arellano
Deprivation And Threat As Predictors Of Executive Functioning And Emotion Regulation In Early Adolescence: The Protective Role Of School Support, Abigail Best De Arellano
Theses and Dissertations
Childhood adversity (CA) impacts a large proportion of US youth with far reaching consequences for development and subsequent health outcomes (McLaughlin et al., 2012). Given the widespread impact of CA, it is imperative to understand how these exposures impact development, as well as identify opportunities for intervention. McLaughlin and Sheridan (2016) proposed the Dimensional Model of Adversity of Psychopathology (DMAP), providing a framework for understanding the heterogeneity of outcomes related to exposure to CA. DMAP emphasizes that deprivation (i.e., lack of expected cognitive or social stimulation) and environmental threat (i.e., exposure to harm or the threat of harm) impacts youth …
Exploring The Holistic Wellness Of Black Women Counselors, Shanta A. Jerideau
Exploring The Holistic Wellness Of Black Women Counselors, Shanta A. Jerideau
Theses and Dissertations
Counselor wellness is crucial for clinician longevity and ethical practice. However, there is limited literature on the holistic wellness of Black women counselors. This manuscript probes into the lived experiences of Black women counselors, particularly in relation to the sociopolitical climate and racial injustices in the United States. Utilizing Consensual Qualitative Research, we examine the experiences of 15 Black women counselors working in counselor education, private practice, and community agencies within the Southeast Region of the United States. We anticipate this approach will enhance counselor education literature and foster increased peer support.
Essential Characteristics And Perceived Needs Of Teachers And School Leaders Of Steam-Focused Elementary Schools: An Exploratory Study, Christopher Abbaleo
Essential Characteristics And Perceived Needs Of Teachers And School Leaders Of Steam-Focused Elementary Schools: An Exploratory Study, Christopher Abbaleo
Theses and Dissertations
While STEAM (science, technology, engineering, arts, and mathematics) education has traditionally been emphasized at the high school level, there is growing recognition of its importance in elementary education. This exploratory, action research multiple-case study identified the essential characteristics of two STEAM-focused elementary schools and how they are operationalized as well as the perceived needs of teachers and school leaders working within the schools. Within-case analyses and a cross-case synthesis revealed both common and distinct STEAM-focused curricular approaches, along with other commonalities such as enriching co-curricular offerings, connections to STEAM careers, professional development, teacher collaboration, visionary leadership, and networking with external …
First Detrital Zircon Provenance Data From Oligocene-Pleistocene Sediment In The Beaufort-Mackenzie Basin, Arctic Ocean, Joseph Martina
First Detrital Zircon Provenance Data From Oligocene-Pleistocene Sediment In The Beaufort-Mackenzie Basin, Arctic Ocean, Joseph Martina
Theses and Dissertations
Sediment, runoff, and nutrient input to the Arctic Ocean plays a critical role in both physical and biological processes that impact regional and global systems. The Beaufort-Mackenzie Basin, situated in the Arctic Ocean offshore northwestern Canada, contains more than 14 km of clastic strata and provides a record of erosion and sediment transport from the Cretaceous to present. Pliocene sedimentation rates within the basin jump nearly 2000% relative to underlying units, but the cause of this shift remains unknown. We used cuttings from the N. Issungnak L-86 well, focusing on the Oligocene-lower Miocene Kugmallit and Mackenzie Bay sequences and the …
Investigating The Immunomodulatory Effects Of Cdk8/19 Inhibitor Senexin631 In A Her2-Positive Breast Cancer Model, Stephen O'Rourke
Investigating The Immunomodulatory Effects Of Cdk8/19 Inhibitor Senexin631 In A Her2-Positive Breast Cancer Model, Stephen O'Rourke
Theses and Dissertations
HER2-positive (HER2⁺) breast cancer is aggressive and often develops resistance to anti-HER2 therapies. CDK8 and CDK19, transcription-associated cyclin-dependent kinases (tCDKs) in the Mediator complex, are dysregulated in HER2⁺ breast cancer, correlate with poor survival, and support transcriptional escape driving therapeutic resistance. Previous studies Previous studies in immune-deficient models demonstrated that CDK8/19 inhibition (CDK8/19i) reduces pro-tumor macrophages (M2Φs), but its role in immune-competent tumors and innate immune–mediated tumor control remains unclear. Since HER2⁺ tumors are often immunogenic and anti-HER2 therapies rely on innate immune activation, reprogramming immunosuppressive M2Φ toward an M1Φ-like phenotype could enhance antitumor immunity. We hypothesized that CDK8/19i modulates …
“Freedom Looks Different For Everyone”: Transforming Pre-Packaged Literacy Programs Through Critical Literacy, Theodore Reginald Martinez
“Freedom Looks Different For Everyone”: Transforming Pre-Packaged Literacy Programs Through Critical Literacy, Theodore Reginald Martinez
Theses and Dissertations
The Hartford Area Education Network (a pseudonym) adopted EL Education (formerly Expeditionary Learning) in response to the passage of the Right to Read Act by the Connecticut General Assembly. Multinational Magnet School, (a pseudonym) which is operated by the Hartford Area Education Network, uses EL Education for its literacy instruction in all kindergarten through fifth-grade classrooms. Module 3 of the fourth-grade sequence discusses perspectives of the American Revolution, though it minimally discusses people of color. Guided by a theoretical framework that incorporates critical pedagogy, Critical Race Theory, and decolonizing pedagogy, my qualitative action research study looked at how critical literacy …
Characterizing The Relationships Between Cranial Geometry, Brain Morphometry, And Brain Mechanical Properties Using Mr Imaging And Elastography, Jessica Restivo
Characterizing The Relationships Between Cranial Geometry, Brain Morphometry, And Brain Mechanical Properties Using Mr Imaging And Elastography, Jessica Restivo
Theses and Dissertations
Traumatic brain injury (TBI) is a global health concern, with over 69 million cases annually. TBI risk depends on subject-specific neuroanatomical variation, yet research often only considers generic finite element (FE) models, based on the geometry and material composition of a 50th percentile male head. Although highly accurate, subject-specific models require expensive magnetic resonance (MR) imaging, elastography, and time-consuming computational resources. There is a need to create subject-specific TBI models that account for subject-specific variations, without neuroimaging. This study aims to create mathematical models to predict brain morphometry (dimensions, volume) [Objective 1] and mechanical properties (shear stiffness, damping ratio, octahedral …
Investigating Mechanisms And Day-Level Factors That Influence Children’S 24-Hour Movement Behaviors, Hannah Parker
Investigating Mechanisms And Day-Level Factors That Influence Children’S 24-Hour Movement Behaviors, Hannah Parker
Theses and Dissertations
Twenty-four hour movement behaviors (i.e., physical activity (PA), screen time (ST), and sleep) are associated with health outcomes, chronic disease (obesity, type 2 diabetes), and mortality. Most literature evaluating children’s 24-hour movement behaviors has focused on static person-level demographic information such as age or biological sex. Relatively less work has examined the variable factors that change day to day, such as environment or context. The Structured Days Hypothesis (SDH) suggests that when children are in structured environments, they have healthier movement behaviors compared to less structured environments where children have more discretionary time to engage in obesogenic behaviors. Besides school/childcare, …
Understanding Community College Students’ Thoughts And Motivations Regarding Tutoring In An Undergraduate Mathematics Course, Whitney Paige Cherekos
Understanding Community College Students’ Thoughts And Motivations Regarding Tutoring In An Undergraduate Mathematics Course, Whitney Paige Cherekos
Theses and Dissertations
This mixed-methods study examines community college students’ thoughts and motivations regarding tutoring, with the aim of identifying disparities in tutoring utilization and engagement at a community college in North Carolina. The purpose of the dissertation is to evaluate tutoring effectiveness and explore students’ perceptions of tutoring. The findings of this study led to proposed solutions to reduce or eliminate the barriers that today’s community college students encounter when needing academic support.
To evaluate tutoring effectiveness, I collected quantitative data from institution registration reports, transcripts, tutoring logs, and an anonymous student survey for students enrolled in multiple sections of a single …
Beyond Entertainment: Unveiling Digital Platform Strategic Implications For International Business Growth Of Individual Entrepreneurs, Hoik Kim
Theses and Dissertations
This dissertation examines how digital identity, comprising visual, psychological, and strategic components, impacts entrepreneurial success on global digital platforms. Rather than treating identity as a static or aesthetic trait, this study conceptualizes it as a dynamic and strategic construct shaped by audience perception, algorithmic systems, and institutional environments. The research is structured into three empirical studies. The first explores how facial visibility and social media engagement affect monetization on YouTube, considering the international context. The second study empirically investigates how a biometric cue influences entrepreneurial performance on digital platforms and interprets the results through the lens of social psychological perspectives. …
In Their Own Words: How Standardization Shapes Student Learning Experiences, Jessica Cantley
In Their Own Words: How Standardization Shapes Student Learning Experiences, Jessica Cantley
Theses and Dissertations
This qualitative action research study explores how students perceive and experience standardized and elective educational environments in a rural, Title I high school in the U.S. South. Through semi-structured interviews and focus group discussions with seven diverse participants, the study investigates student-defined learning objectives, motivation and engagement across different classes, and youth perceptions of valuable learning experiences. The research is grounded in constructivism, applying feminist theory and critical race theory as lenses to challenge power dynamics and promote equality in education.
Findings confirm the problem of practice that inspired the study by revealing a contrast between students’ experiences in standardized …
The Influence Of Sex Education On Sexual Behaviors From Adolescence To Young Adulthood In South Carolina, Megan Elizabeth Austin
The Influence Of Sex Education On Sexual Behaviors From Adolescence To Young Adulthood In South Carolina, Megan Elizabeth Austin
Theses and Dissertations
Sex education in South Carolina (SC) is known to be limited, which may influence adolescent sexual behaviors, leading to a higher likelihood of lower ages of sexual initiation, more sexual partners, and more experiences of sexual violence. These behaviors are associated with many negative health outcomes.
A political content analysis of bills, laws, and educational standards provides insight to changes in political discourse around sex education from when the Comprehensive Health Education Act (CHEA) was passed in 1988 until 2024. A variable created through this analysis is used along with SC Youth Risk Behavior Survey data to assess changes in …
Seeding Science: Exploring Impacts From Interdisciplinary Project-Based Learning Experiences On Preservice Teachers Science Teaching Self-Efficacy, Kathryn Ruth Madden
Seeding Science: Exploring Impacts From Interdisciplinary Project-Based Learning Experiences On Preservice Teachers Science Teaching Self-Efficacy, Kathryn Ruth Madden
Theses and Dissertations
Early childhood and elementary education preservice teachers often report having limited firsthand experiences in constructivist, inquiry-based science instruction. This can be a factor in contributing to nervous or anxious feelings about teaching science to young learners. To address this critical problem, this study explored the impact of interdisciplinary project-based learning (PBL) experiences on preservice teachers' selfefficacy. The study extended over six weeks of the preservice teachers' science methods courses. The early childhood participants engaged in interdisciplinary PBL by designing and exploring schoolyard gardens. The elementary participants investigated the local saltmarsh ecosystem focusing on the plants and animals. The PBL experiences …
Some Likelihood-Based Methods For Clustering Functional Data, Tong Shan
Some Likelihood-Based Methods For Clustering Functional Data, Tong Shan
Theses and Dissertations
The analysis of functional data is an increasingly relevant part of statistics. The exploratory data analytic method of cluster analysis plays a very important role in different fields. Over the years, researchers have developed many clustering approaches, striving to achieve more accurate and efficient clustering. In Chapter 1, we aim to improve the accuracy of our outcome when clustering functional data. To achieve this goal, we use a predictive likelihood function which serves as an objective function to optimize in order to determine the most appropriate clusters. To optimize the objective function over the space of clustering partitions, we produce …
Saw Biosensor For The Detection Of Cyanobacteria And Cyanotoxin, Tally Bovender
Saw Biosensor For The Detection Of Cyanobacteria And Cyanotoxin, Tally Bovender
Theses and Dissertations
The growing prevalence of cyanobacterial blooms and associated cyanotoxins, such as microcystin-LR (MC-LR), presents a significant threat to water quality and public health. Conventional detection methods, including ELISA and PCR, are often time-consuming, expensive, and require trained personnel, limiting their application in field settings. Hence, a miniaturized, quick testing sensor is proposed to circumvent the current sensing challenges for real time, in-situ diagnostics of MC-LR. The proposed high-frequency ultrasonic sensor employs surface acoustic waves (SAW). The sensor was designed using a multi-physics simulation tool to understand wave propagation in the piezoelectric substrate (lithium tantalate) and optimize the design of the …
Optical And Thermal Characterization Of Vertically Conducting Β-Ga₂O₃ Diodes Grown On 4h-Sic Substrates For Short-Wavelength (<254 Nm) Detection, Muhammad Hassan Tahir
Optical And Thermal Characterization Of Vertically Conducting Β-Ga₂O₃ Diodes Grown On 4h-Sic Substrates For Short-Wavelength (<254 Nm) Detection, Muhammad Hassan Tahir
Theses and Dissertations
The advancement of compact, thermally stable, and efficient devices for deepultraviolet (DUV) detection below 254 nm is critical for solar-blind sensing, radiation monitoring, and high-power electronics. This thesis presents the growth, fabrication, and detailed optical and thermal characterization of vertically conducting β-gallium oxide (βGa₂O₃) Schottky barrier diodes (SBDs) grown on n-type 4H-Silicon Carbide (4H-SiC) substrates using metal-organic chemical vapor deposition (MOCVD).
β-Ga₂O₃ is an ultra-wide bandgap (UWBG) semiconductor (~4.8 eV) with intrinsic DUV transparency and high breakdown electric field, making it an ideal candidate for short-wavelength photodetection. However, its low thermal conductivity limits its vertical device performance. To overcome this, …
Awareness And Practice Methods For Musicians With Invisible Disabilities: Insights Gained From Playing The Flute With Ehlers-Danlos Syndrome, Jessica Pelltier
Awareness And Practice Methods For Musicians With Invisible Disabilities: Insights Gained From Playing The Flute With Ehlers-Danlos Syndrome, Jessica Pelltier
Theses and Dissertations
Ehlers-Danlos Syndrome (EDS) is a connective tissue disorder that presents significant physical and mental challenges for musicians, particularly in instrumental performance. These challenges may include chronic pain, joint instability, fatigue, anxiety, and depression. While such symptoms are associated with EDS, they are not exclusive to it and are also common among individuals with other invisible disabilities, such as fibromyalgia, postural orthostatic tachycardia syndrome (POTS), celiac disease, attention-deficit/hyperactivity disorder (ADHD), generalized anxiety disorder (GAD), and chronic fatigue syndrome (ME/CFS). This study explores the experiences of flutists with EDS and other invisible disabilities, focusing on the coping strategies and adaptations they use …
Aggressive, Adaptive, And Underestimated: From Allergy To Arboviruses, The Rise Of The Lone Star Tick, Emily Ellen Owens Pickle
Aggressive, Adaptive, And Underestimated: From Allergy To Arboviruses, The Rise Of The Lone Star Tick, Emily Ellen Owens Pickle
Theses and Dissertations
Once considered a nuisance with little medical importance, the lone star tick (Amblyomma americanum, Acari:Ixodidae) has emerged as a formidable vector driving a new era of public health threats across the United States of America. This dissertation traces the rise of the lone star tick from obscurity to infamy, exploring its expanding geographic range, unique immunologic impacts on humans, and role in the transmission of emerging tickborne viruses. Through a series of integrated studies, this work characterizes the epidemiology, immunology, and ecological context of tick-borne diseases in the southeastern U.S., with a particular focus on α-Gal syndrome (AGS), …
Multi-Task Deep Learning Approach For Segmenting And Classifying Competitive Swimming Activities Using A Single Imu, Mark Shperkin
Multi-Task Deep Learning Approach For Segmenting And Classifying Competitive Swimming Activities Using A Single Imu, Mark Shperkin
Theses and Dissertations
Competitive swimming performance analysis has traditionally relied on manual video review and multi-sensor systems, both of which are resource-intensive and impractical for everyday training use. This study investigates whether a single wrist-worn inertial measurement unit (IMU) can be used to automatically segment and classify swimming activities with high accuracy. We propose a multi-task deep learning pipeline based on the MTHARS (Multi-Task Human Activity Recognition and Segmentation) architecture introduced by Duan et al. to perform stroke classification, lap segmentation, stroke count estimation, and underwater kick count estimation. Data were collected from eleven collegiate-level swimmers wearing left-wrist-mounted IMUs, each performing five 100-yard …
Effect Of Growth Conditions On The Performance Of Vertically Conducting Beta-Ga2o3 Diodes On 4h-Sic Substrate By Mocvd, Nifat Jahan Nipa
Effect Of Growth Conditions On The Performance Of Vertically Conducting Beta-Ga2o3 Diodes On 4h-Sic Substrate By Mocvd, Nifat Jahan Nipa
Theses and Dissertations
This thesis highlights the critical influence of doping strategies, specifically co-delta doping with silicon (Si) and indium (In), on improving the structural quality and device performance of β-Ga₂O₃-based Schottky barrier diodes (SBDs). To achieve better thermal management, β-Ga₂O₃ thin film was grown on bulk 4H-SiC substrates using the Metal-Organic Chemical Vapor Deposition (MOCVD) technique, renowned for its precise control over composition, thickness and doping profile. The ultra-wide bandgap (UWBG), high critical breakdown field and low turn-on resistance of β-Ga₂O₃ make it a strong candidate for next-generation power electronics and short-wavelength detection in extreme environments. However, the presence of structural defects …
The Impact Of Adverse Childhood Experiences And Living With Hiv On Cardiovascular Health And Cardiometabolic Disorders In An African Population: An Analysis Of The Indepth Community In Rural South Africa, Samuel Gavi
Theses and Dissertations
Background: Adverse Childhood Experiences (ACEs) have been shown to be associated with cardiometabolic disorders (CMDs) and poor CVH; however, in Africa, this has not been well studied. Cardiovascular health (CVH) is an important measure of risk for cardiovascular diseases (CVD) developed by the American Heart Association (AHA). With the increasing prevalence of CVD in Africa, CVH is a potential upstream prevention approach. Africa also has the highest prevalence of HIV, and an increasing prevalence of comorbidities associated with it. Various mechanisms have been investigated to explain the relationship between CVD and chronic HIV infection. This study explores the potential relationship …
Large Lessons From A Tiny Wasp, Mark Wanner
Functional Time Transformation Model With Applications To Digital Health, Rahul Ghosal Ph.D., Marcos Matabuena, Sujit K. Ghosh
Functional Time Transformation Model With Applications To Digital Health, Rahul Ghosal Ph.D., Marcos Matabuena, Sujit K. Ghosh
Faculty Publications
The advent of wearable and sensor technologies now leads to functional predictors which are intrinsically infinite dimensional. While the existing approaches for functional data and survival outcomes lean on the well-established Cox model, the proportional hazard (PH) assumption might not always be suitable in real-world applications. Motivated by physiological signals encountered in digital medicine, we develop a more general and flexible functional time-transformation model for estimating the conditional survival function with both functional and scalar covariates. A partially functional regression model is used to directly model the survival time on the covariates through an unknown monotone transformation and …
Review Of Viri Dignitatem: Personhood, Masculinity, And Fatherhood In The Thought Of John Paul Ii, Christine Falk Dalessio
Review Of Viri Dignitatem: Personhood, Masculinity, And Fatherhood In The Thought Of John Paul Ii, Christine Falk Dalessio
Theology Faculty Research and Publications
No abstract provided.
Practicing Dentistry In The Age Of Periodontal Risk Management, Roger N. Warren D.D.S., Liana Umbrio D.D.S., Leena Palomo D.D.S., M.S.D.
Practicing Dentistry In The Age Of Periodontal Risk Management, Roger N. Warren D.D.S., Liana Umbrio D.D.S., Leena Palomo D.D.S., M.S.D.
The New York State Dental Journal
Purpose of review: To provide clinicians with knowledge of periodontal risk assessment that can be applied chairside effortlessly.
Recent findings: Detecting periodontal risk factors early may reduce the morbidity of oral and systemic diseases, as oral and systemic health can have a bidirectional relationship.
Summary: Dental professionals are equipped with evidence-based risk factors to predict and prevent the progression of periodontal disease. Implementing chairside risk assessment allows for prevention and early intervention, potentially reducing healthcare costs and promoting simpler solutions in an unpredictable economy.
To Thine Own Self Be True
The New York State Dental Journal
THE NYSDA DIVERSITY and Inclusion Task Force, charged with acknowledging and promoting the disparate components of the Association’s membership, joins in the national observance of June as Pride Month. Designated in 1999, Pride Month commemorates the contributions to life and culture made by lesbian, gay, bisexual, transgender and queer people. Among those celebrating and being celebrated this month is NYSDA member Alison Rascon, D.D.S., M.S.
Orofacial Manifestations Of Highly Active Antiretroviral Therapy (Haart) And Pre-Exposure Prophylaxis (Prep): Implications For Dental Care And Guidelines For Management, Alec Donelian, Yuedi Yu, Ezzard Rolle Dds, Alison Newgard Dds
Orofacial Manifestations Of Highly Active Antiretroviral Therapy (Haart) And Pre-Exposure Prophylaxis (Prep): Implications For Dental Care And Guidelines For Management, Alec Donelian, Yuedi Yu, Ezzard Rolle Dds, Alison Newgard Dds
The New York State Dental Journal
HAART and PrEP have demonstrated reduction of HIV-related mortality and HIV infection, respectively. A range of orofacial side effects has been associated with both HAART and PrEP. As PrEP usage has increased, there has also been an increase in sexually transmitted infections that have orofacial symptoms. As oral health-care providers, it is important that we recognize these orofacial side effects and symptoms. Further, we offer clinical recommendations for dental professionals treating patients who are on either HAART or PrEP and their associated risk factors.
Genome-Wide Association Meta-Analysis Of Human Olfactory Identification Discovers Sex-Specific And Sex-Differential Genetic Variants, Franz Förster, David Emmert, Katrin Horn, Janne Pott, Johannes Frasnelli, Mohammed Aslam Imtiaz, Konstantinos Melas, Valentina Talevi, Honglei Chen, Christoph Engel, Michele Filosi, Myriam Fornage, Martin Gögele, Markus Löffler, Thomas H Mosley, Cristian Pattaro, Peter Pramstaller, Srishti Shrestha, N Ahmad Aziz, Monique M B Breteler, Kerstin Wirkner, Markus Scholz, Christian Fuchsberger
Genome-Wide Association Meta-Analysis Of Human Olfactory Identification Discovers Sex-Specific And Sex-Differential Genetic Variants, Franz Förster, David Emmert, Katrin Horn, Janne Pott, Johannes Frasnelli, Mohammed Aslam Imtiaz, Konstantinos Melas, Valentina Talevi, Honglei Chen, Christoph Engel, Michele Filosi, Myriam Fornage, Martin Gögele, Markus Löffler, Thomas H Mosley, Cristian Pattaro, Peter Pramstaller, Srishti Shrestha, N Ahmad Aziz, Monique M B Breteler, Kerstin Wirkner, Markus Scholz, Christian Fuchsberger
Faculty, Staff and Student Publications
Smelling is a human sense, expressing strong sexual dimorphisms. We aim to improve the knowledge of the genetics of human olfactory perception by performing an exploratory genome-wide association meta-analysis of up to 21,495 individuals of European ancestry. By sex-stratified and overall analysis of the identification of twelve odours and an identification score, we discovered ten independent loci, seven of them novel, with trait-wise genome-wide significance (p < 5 × 10−8) involving five odours. Seven of these loci, including four novel ones, are also significant using a stricter study-wide significance threshold (p < 3.85 × 10−9). Loci were predominantly located within clusters of olfactory receptors. Two loci were female-specific while one was sex-differential with respective candidate genes containing androgen response elements. Two-sample Mendelian randomization was applied to search for causal relationships between sex hormones, odour identification and neurodegenerative diseases. A causal negative effect was detected for Alzheimer’s disease on the identification score. These findings deepen our understanding of the genetic basis of olfactory perception and its interaction with sex, prioritizing mechanisms for further molecular research.
Realism, Instrumentalism, And The Language Of Science Teaching: A Quantitative Study, James M. Almand
Realism, Instrumentalism, And The Language Of Science Teaching: A Quantitative Study, James M. Almand
Doctor of Education (Ed.D)
The purpose of this quantitative, non-experimental, correlational study was to investigate how science educators' epistemological orientations, specifically, their leanings toward realism or instrumentalism, influence the degree of certainty in their instructional language. The study addressed a significant gap in science education literature by empirically analyzing whether educators' philosophical beliefs about the nature of scientific knowledge predict the language they use when teaching science. Data were collected through a researcher-developed survey, the Science Educators' Epistemological Beliefs and Classroom Language Practices Survey, which measured participants' epistemological positions and linguistic tendencies across a sample of current and former science educators in the United …
Teratogenic Effects Of Serotonin Receptor 2b Disruption On The Migration And Cardiac Derivatives Of The Cardiac Neural Crest, Brian K. Wells, Gwyneth K. Garramone, Amira Mahomed, Max Ezin
Teratogenic Effects Of Serotonin Receptor 2b Disruption On The Migration And Cardiac Derivatives Of The Cardiac Neural Crest, Brian K. Wells, Gwyneth K. Garramone, Amira Mahomed, Max Ezin
Biology Faculty Works
Background: Cardiac neural crest cells (cNCCs) are critical for heart development, and their disruption can result in congenital heart defects. Serotonin (5-HT) signaling, specifically via 5-HT2B and 5-HT2C receptors, regulates diverse physiological processes, including neural crest migration. This study investigates how modulation of 5-HT2B and 5-HT2C receptor activity impacts cNCC migration and the development of their derivatives, with relevance to serotonergic drug safety during pregnancy.
Methods
Chicken embryos at HH8 were treated with 50 μL of 20 μM 1-Methylpsilocin (1-MP), an inverse agonist of 5-HT2B and agonist of 5-HT2C, and collected at HH14 to assess cNCC migration. Embryos were pre-treated …