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2025

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Nantucket Eelgrass Management Plan, Kimberly Starbuck, Kristin Uiterwyk, Shannon Hogan Jul 2025

Nantucket Eelgrass Management Plan, Kimberly Starbuck, Kristin Uiterwyk, Shannon Hogan

Urban Harbors Institute Publications

Eelgrass is a critical component of our coastal ecosystem, supporting marine biodiversity, improving water quality, and helping to stabilize the shoreline. This planning effort aims to support the long-term health and sustainability of eelgrass habitats in our local waters.

Eelgrass (Zostera marina L.) is a subtidal seagrass found on both the east and west coasts of North America. Over the last 40 years, eelgrass has declined worldwide as a result of increased turbidity, algal blooms, physical disturbances, disease, and a host of other stressors. Specifically, in Massachusetts, the eelgrass population has declined approximately 50% in the last 30 …


L-Quebrachitol Modulates The Anti-Convulsant Effects Of Carbamazepine Possibly Through Voltage-Gated Sodium Channel Blocking Mechanism In Chicks: In Vivo And In Silico Studies, Asifa Asrafi, Mohammad Aslam, Ali G. Alkhathami, Md. Sakib Hossain, Imam Hossen Rakib, Md. Sakib Al Hasan, Feroz Khan Nun, Md. Faisal Amin, Muhammad Torequl Islam Jul 2025

L-Quebrachitol Modulates The Anti-Convulsant Effects Of Carbamazepine Possibly Through Voltage-Gated Sodium Channel Blocking Mechanism In Chicks: In Vivo And In Silico Studies, Asifa Asrafi, Mohammad Aslam, Ali G. Alkhathami, Md. Sakib Hossain, Imam Hossen Rakib, Md. Sakib Al Hasan, Feroz Khan Nun, Md. Faisal Amin, Muhammad Torequl Islam

School of Integrative Biological & Chemical Sciences Faculty Publications

Introduction: L-Quebrachitol (LQB), a naturally occurring bioactive compound, exhibits anti-inflammatory, anti-oxidant, anti-cancer, and anti-diabetic properties. However, its therapeutic potential in convulsant management remains largely unexplored. The objective of this study was to investigate the anticonvulsant effects of LQB in an In Vivo model and to examine its molecular interactions via In Silico docking simulations.

Methods: In the In Vivo study, pentylenetetrazol (PTZ) was administered intraperitoneally (i.p.) at 80 mg/kg to induce convulsions, and the test animals were treated orally with three doses of LQB (1, 5, and 10 mg/kg), with carbamazepine (CBZ) at 80 mg/kg as a standard drug.

Results: …


Using Radium Isotopes To Compare Nutrient Inputs Via Submarine Groundwater Discharge To Offshore Export On The West Florida Shelf, Andrew L. Lindgren Jul 2025

Using Radium Isotopes To Compare Nutrient Inputs Via Submarine Groundwater Discharge To Offshore Export On The West Florida Shelf, Andrew L. Lindgren

OES Theses and Dissertations

Radium isotopes have been used to trace submarine groundwater discharge (SGD) and associated nutrient and metal inputs into the coastal ocean. They have also been used to estimate rates of diffusive mixing and export fluxes of dissolved constituents offshore. However, use of both approaches in tandem to determine the fate of groundwater inputs after they enter the coastal ocean is still relatively unexplored. Radium isotopes and nutrients were measured in two cross-shelf cruises on the West Florida Shelf in different seasons and in quarterly sampling of offshore wells. Through 226Ra mass balance and 223Ra-derived diffusive mixing rates, inputs of nutrients …


The Relationships Between Expectancy-Value Beliefs, Communal Value Beliefs, Family Identity, And Academic Persistence Among First- And Continuing-Generation College Students, Douglas W. Snuffer Jul 2025

The Relationships Between Expectancy-Value Beliefs, Communal Value Beliefs, Family Identity, And Academic Persistence Among First- And Continuing-Generation College Students, Douglas W. Snuffer

STEMPS Theses & Dissertations

First-generation college students (students for whom neither parent has a 4-year college degree) have lower college graduation rates than their continuing-generation peers (Cahalan et al., 2021; Fry, 2021). First-generation students may experience barriers to higher education, leading to lower levels of academic achievement motivation for college. Two of these barriers may include 1) cultural mismatch (Stephens, Fryberg, et al., 2012) with colleges via communal value (a value set that emphasizes community and family over the self) and 2) a strong sense of family identity, which lends itself to perceived family obligations (Fuligni et al., 2007). To examine the relationships between …


Returning To Nature: A Virtue-Based Approach To Urban Sustainability, Liam A. L. Cormack Jul 2025

Returning To Nature: A Virtue-Based Approach To Urban Sustainability, Liam A. L. Cormack

Cities and the Environment (CATE)

This paper advocates for a pragmatic and virtue-ethics-based approach to urban sustainability initiatives that prioritizes the consideration of moral responsibility. Looking at literature on rewilding, this paper argues that the principle of ecophronesis, and the larger discipline of ecopracticology, offers a compelling framework for integrating diverse opinions on the future of conservation from different disciplines and ecological stakeholders. Ultimately, an ecophronetic approach to urban sustainability initiatives facilitates a sense of conceptual rewilding that disregards the nature-culture dualism paradigm limiting Western environmental thought and may help address the perceived alienation from nature characterized by nature-deficit disorder.


Quantifying Marine Carbon Dioxide Removal Via Alkalinity Enhancement Across Circulation Regimes Using Ecco-Darwin And 1d Models, Kay Suselj, Dustin Carroll, Daniel Whitt, Bridget Samuels, Dimitris Menemenlis, Hong Zhang, Nate Beatty, Anna Savage Jul 2025

Quantifying Marine Carbon Dioxide Removal Via Alkalinity Enhancement Across Circulation Regimes Using Ecco-Darwin And 1d Models, Kay Suselj, Dustin Carroll, Daniel Whitt, Bridget Samuels, Dimitris Menemenlis, Hong Zhang, Nate Beatty, Anna Savage

Faculty Research, Scholarly, and Creative Activity

Ocean Alkalinity Enhancement (OAE) is emerging as a viable method for removing anthropogenic (Formula presented.) emissions from the atmosphere to mitigate climate change. To achieve substantial carbon reductions, OAE would need to be deployed at scale across the global ocean. Hence, there is a need to quantify how the efficiency of OAE varies globally across a range of space-time scales in preparation for field deployments. Here we develop a marine carbon dioxide removal (mCDR) efficiency evaluation framework based on the data-assimilative ECCO-Darwin ocean biogeochemistry model, which separates and quantifies two key factors over seasonal to multi-annual timescales: (a) mCDR potential, …


Automated Assignment Grading With Large Language Models: Insights From A Bioinformatics Course, Pavlin G Poličar, Martin Špendl, Tomaž Curk, Blaž Zupan Jul 2025

Automated Assignment Grading With Large Language Models: Insights From A Bioinformatics Course, Pavlin G Poličar, Martin Špendl, Tomaž Curk, Blaž Zupan

Faculty, Staff and Students Publications

Motivation: Providing students with individualized feedback through assignments is a cornerstone of education that supports their learning and development. Studies have shown that timely, high-quality feedback plays a critical role in improving learning outcomes. However, providing personalized feedback on a large scale in classes with large numbers of students is often impractical due to the significant time and effort required. Recent advances in natural language processing and large language models (LLMs) offer a promising solution by enabling the efficient delivery of personalized feedback. These technologies can reduce the workload of course staff while improving student satisfaction and learning outcomes. Their …


Endothelium- And Fibroblast-Derived C-Type Natriuretic Peptide Prevents The Development And Progression Of Aortic Aneurysm, Aisah A Aubdool, Amie J Moyes, Cristina Perez-Ternero, Reshma S Baliga, Jaspinder Singh Sanghera, M Taaha Syed, Kareemah Jaigirdar, Anmolpreet K Panesar, Janice C Tsui, Yanming Li, Hernan G Vasquez, Ying H Shen, Scott A Lemaire, Juliette Raffort, Ziad Mallat, Hong S Lu, Alan Daugherty, Adrian J Hobbs Jul 2025

Endothelium- And Fibroblast-Derived C-Type Natriuretic Peptide Prevents The Development And Progression Of Aortic Aneurysm, Aisah A Aubdool, Amie J Moyes, Cristina Perez-Ternero, Reshma S Baliga, Jaspinder Singh Sanghera, M Taaha Syed, Kareemah Jaigirdar, Anmolpreet K Panesar, Janice C Tsui, Yanming Li, Hernan G Vasquez, Ying H Shen, Scott A Lemaire, Juliette Raffort, Ziad Mallat, Hong S Lu, Alan Daugherty, Adrian J Hobbs

Faculty, Staff and Students Publications

Background: Thoracic (TAA) and abdominal (AAA) aortic aneurysm are life-threatening diseases characterized by dilation, inflammation, and structural weakness; development of pharmacological therapies is desperately needed. CNP (C-type natriuretic peptide) plays a key role in vascular homeostasis, mediating vasodilator, anti-inflammatory, and antiatherogenic actions. Since such processes drive AA, we determined the role of endogenous CNP in offsetting pathogenesis.

Methods: Tissue from patients with AA was analyzed to determine the consequences on CNP signaling. Ascending and suprarenal aortic diameters were assessed at baseline and following Ang II (angiotensin II; 1.44 mg/kg per day) infusion in wild-type, endothelium-restricted (ecCNP-/-), fibroblast-restricted (fbCNP-/-), global CNP …


Figo Position Statement: Gamete Donations, Laurie Henry, Aris Antsaklis, Dov Feldberg, Jaideep Malhotra, Suchitra Pandit, Carlos Salazar, Alex Vidaeff, Rafal Zadykowicz, M Louise Hull, Nikhil Purandare Jul 2025

Figo Position Statement: Gamete Donations, Laurie Henry, Aris Antsaklis, Dov Feldberg, Jaideep Malhotra, Suchitra Pandit, Carlos Salazar, Alex Vidaeff, Rafal Zadykowicz, M Louise Hull, Nikhil Purandare

Faculty, Staff and Students Publications

Gamete donation has become a crucial part of Assisted Reproductive Technologies (ARTs), providing hope to individuals, including those who may have no other option for parenthood. This process comes with a wide range of ethical, medical, and legal challenges that need to be carefully addressed to protect the well-being and rights of all parties involved: donors, recipients, and offspring. Navigating these complexities requires strict ethical standards, robust regulatory frameworks, and international collaboration. By standardizing these, the field of gamete donation can continue to develop while ensuring that all parties are well informed and safeguarded. This paper explores the ethical concerns …


Inhibition Of The Gsk3Β/Nav16 Complex Suppresses Early-Stage Alzheimer’S Hyperexcitability, Timothy John Baumgartner, Manuel Silva-Pérez, Zahra Haghighijoo, Nolan Michael Dvorak, Aditya Kumar Singh, Nana Aboadwe Goode, Jully Singh, Berenice Gutierrez Grebenkova, Mate Marosi, Jessica Di Re, Leandra Koff, Wissarut Wijitrmektong, Manu Bala, Hanyue Liao, Marijn Lijffijt, Adam Thomas Szafran, Michael James Bolt, Michael A Mancini, Gregory D Cuny, Diana Shu-Lian Chow, Agenor Limon, Jeannie Chin, Fernanda Laezza Jul 2025

Inhibition Of The Gsk3Β/Nav16 Complex Suppresses Early-Stage Alzheimer’S Hyperexcitability, Timothy John Baumgartner, Manuel Silva-Pérez, Zahra Haghighijoo, Nolan Michael Dvorak, Aditya Kumar Singh, Nana Aboadwe Goode, Jully Singh, Berenice Gutierrez Grebenkova, Mate Marosi, Jessica Di Re, Leandra Koff, Wissarut Wijitrmektong, Manu Bala, Hanyue Liao, Marijn Lijffijt, Adam Thomas Szafran, Michael James Bolt, Michael A Mancini, Gregory D Cuny, Diana Shu-Lian Chow, Agenor Limon, Jeannie Chin, Fernanda Laezza

Faculty, Staff and Students Publications

Introduction: Network hyperexcitability (NH) is observed in patients with early-stage Alzheimer's disease (AD), emerging decades before cognitive decline. A key molecular determinant of NH is voltage-gated Na+ channel 1.6 (Nav1.6), which mediates action potential firing in CA1 hippocampal neurons. Ameliorating NH through inhibition of the glycogen-synthase kinase 3β (GSK3β/Nav1.6 complex may provide immediate benefits to cognition and memory and slow AD progression.

Methods: Hight-throughput virtual screening and multiple in vitro biological assays were utilized to identify compound 1063. Patch-clamp electrophysiology and electroencephalogram recordings were utilized to functionally assess 1063 in models of AD neuropathology.

Results: Building on previous studies identifying …


Cytokine Release Syndrome And Neurotoxicity Following Cd19 Car-T In B-Cell Lymphoma, Roni Shouval, Christopher Strouse, Soyoung Kim, Temitope Oloyede, Sairah Ahmed, Farrukh T Awan, Danny Luan, Veronika Bachanova, Talha Badar, Merav Bar, Pere Barba, Amer M Beitinjaneh, Amanda Cashen, Bhagirathbhai Dholaria, Mahmoud Elsawy, Siddhartha Ganguly, Praveen Ramakrishnan Geethakumari, Uri Greenbaum, Hamza Hashmi, Laquisa C Hill, Michael D Jain, Tania Jain, Partow Kebriaei, Adam S Kittai, Frederick L Locke, Premal D Lulla, Elena Mead, Joseph P Mcguirk, Alberto Mussetti, Taiga Nishihori, Amanda L Olson, Martina Pennisi, Miguel-Angel Perales, Peter A Riedell, Wael Saber, Abu-Sayeef Mirza, Margarida Magalhaes-Silverman, Elizabeth J Shpall, Mohamed Sorror, Kitsada Wudhikarn, Cameron J Turtle, Amy Moskop, Marcelo C Pasquini Jul 2025

Cytokine Release Syndrome And Neurotoxicity Following Cd19 Car-T In B-Cell Lymphoma, Roni Shouval, Christopher Strouse, Soyoung Kim, Temitope Oloyede, Sairah Ahmed, Farrukh T Awan, Danny Luan, Veronika Bachanova, Talha Badar, Merav Bar, Pere Barba, Amer M Beitinjaneh, Amanda Cashen, Bhagirathbhai Dholaria, Mahmoud Elsawy, Siddhartha Ganguly, Praveen Ramakrishnan Geethakumari, Uri Greenbaum, Hamza Hashmi, Laquisa C Hill, Michael D Jain, Tania Jain, Partow Kebriaei, Adam S Kittai, Frederick L Locke, Premal D Lulla, Elena Mead, Joseph P Mcguirk, Alberto Mussetti, Taiga Nishihori, Amanda L Olson, Martina Pennisi, Miguel-Angel Perales, Peter A Riedell, Wael Saber, Abu-Sayeef Mirza, Margarida Magalhaes-Silverman, Elizabeth J Shpall, Mohamed Sorror, Kitsada Wudhikarn, Cameron J Turtle, Amy Moskop, Marcelo C Pasquini

Faculty, Staff and Students Publications

Chimeric antigen receptor T cell (CAR-T) therapy is an effective treatment for relapsed-refractory large B-cell lymphoma (LBCL). However, toxicities, particularly cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), remain significant concerns. Analyze temporal trends, risk factors, and associations between these toxicities and their severity. In this registry study by the Center for International Blood and Marrow Transplant Research, we studied CRS and ICANS in 1916 LBCL patients treated with commercial CAR-T therapies (axicabtagene ciloleucel 74.9%, tisagenlecleucel 25.1%) between 2018 and 2020. Outcomes include development of CRS/ICANS, timing and severity according to ASTC grading, overall survival (OS). Risk …


Complete Genomic Characterization Of Global Pathogens Respiratory Syntical Virus And Human Norovirus Using Probe Based Capture Enrichment, Sravya V Bhamidipati, Anil Surathu, Hsu Chao, Daniel P Agustinho, Qin Xiang, Kavya Kottapalli, Abirami Santhanam, Zeineen Momin, Kimberly Walker, Vipin K Menon, George Weissenberger, Nathanael Emerick, Faria Mahjabeen, Qingchang Meng, Jianhong Hu, Richard Sucgang, David Henke, Fritz J Sedlazeck, Ziad M Khan, Ginger A Metcalf, Vasanthi Avadhanula, Pedro A Piedra, Sasirekha Ramani, Robert L Atmar, Mary K Estes, Joseph F Petrosino, Richard A Gibbs, Donna M Muzny, Sara Cregeen Javornik, Harsha Doddapaneni Jul 2025

Complete Genomic Characterization Of Global Pathogens Respiratory Syntical Virus And Human Norovirus Using Probe Based Capture Enrichment, Sravya V Bhamidipati, Anil Surathu, Hsu Chao, Daniel P Agustinho, Qin Xiang, Kavya Kottapalli, Abirami Santhanam, Zeineen Momin, Kimberly Walker, Vipin K Menon, George Weissenberger, Nathanael Emerick, Faria Mahjabeen, Qingchang Meng, Jianhong Hu, Richard Sucgang, David Henke, Fritz J Sedlazeck, Ziad M Khan, Ginger A Metcalf, Vasanthi Avadhanula, Pedro A Piedra, Sasirekha Ramani, Robert L Atmar, Mary K Estes, Joseph F Petrosino, Richard A Gibbs, Donna M Muzny, Sara Cregeen Javornik, Harsha Doddapaneni

Faculty, Staff and Students Publications

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in children worldwide, while human noroviruses (HuNoV) are a leading cause of epidemic and sporadic acute gastroenteritis. Generating full-length genome sequences for these viruses is crucial for understanding viral diversity and tracking emerging variants. However, obtaining high-quality sequencing data is often challenging due to viral strain variability, quality, and low titers. Here, we present a set of comprehensive oligonucleotide probe sets designed from 1,570 RSV and 1,376 HuNoV isolate sequences in GenBank. Using these probe sets and a capture enrichment sequencing workflow, 85 RSV positive nasal swab …


Baseline Cognition And Demographic, Lifestyle, And Cardiovascular Risk Factors In Us Pointer, Kathryn V Papp, Sarah Tomaszewski Farias, Marjorie Howard, Amber Thro, Tiia Ngandu, Brad Caudle, Bonnie C Sachs, Michelle Chan, Kristin R Krueger, Elizabeth R T Hartman, Athene Lee, Michele K York, Marie T Austin, Kathryn E Demos, Thomas M Holland, Xiaoyan Leng, Rema Raman, Heather M Snyder, Maria C Carrillo, Rachel A Whitmer, Mark A Espeland, Laura D Baker Jul 2025

Baseline Cognition And Demographic, Lifestyle, And Cardiovascular Risk Factors In Us Pointer, Kathryn V Papp, Sarah Tomaszewski Farias, Marjorie Howard, Amber Thro, Tiia Ngandu, Brad Caudle, Bonnie C Sachs, Michelle Chan, Kristin R Krueger, Elizabeth R T Hartman, Athene Lee, Michele K York, Marie T Austin, Kathryn E Demos, Thomas M Holland, Xiaoyan Leng, Rema Raman, Heather M Snyder, Maria C Carrillo, Rachel A Whitmer, Mark A Espeland, Laura D Baker

Faculty, Staff and Students Publications

Introduction: Validation of the primary cognitive composite and baseline cognitive characteristics are presented for the US-Study-to-Protect-Brain-Health-Through-Lifestyle-Intervention-to-Reduce-Risk (US POINTER).

Methods: US POINTER is a multicenter, randomized clinical trial of two lifestyle interventions testing cognitive benefit in older adults without significant cognitive impairment but at-risk for decline due to well-established factors. Cognition is measured using a global cognitive composite (US POINTER modified Neuropsychological Test Battery-PmNTB).

Results: The PmNTB is a valid cognitive composite, exhibiting good psychometric properties and tracking with other established outcomes. Among the 2111 enrolled participants (mean age = 68.2 years, 69% women, 31% from race and ethnic minoritized groups), …


Emergence Of Cellular Nematic Order Is A Conserved Feature Of Gastrulation In Animal Embryos, Xin Li, Robert J Huebner, Margot L K Williams, Jessica Sawyer, Mark Peifer, John B Wallingford, D Thirumalai Jul 2025

Emergence Of Cellular Nematic Order Is A Conserved Feature Of Gastrulation In Animal Embryos, Xin Li, Robert J Huebner, Margot L K Williams, Jessica Sawyer, Mark Peifer, John B Wallingford, D Thirumalai

Faculty, Staff and Students Publications

Cells undergo dramatic morphological changes during embryogenesis, yet how these changes affect the formation of ordered tissues remains elusive. Here, we show that a phase transition leading to the formation of a nematic liquid crystal state during gastrulation in the development of embryos of fish, frogs, and fruit flies occurs by a common mechanism despite substantial differences between these evolutionarily distant animals. Importantly, nematic order forms early before any discernible changes in the shapes of cells. All three species exhibit similar propagation of the nematic phase, reminiscent of nucleation and growth mechanisms. The spatial correlations in the nematic phase in …


Metabolomic Data May Support The Development Of Personalized Nutrition Approaches To Type 2 Diabetes Management, Danielle J Lee, Shragvi Balaji, Jerome I Rotter, Alexis C Wood Jul 2025

Metabolomic Data May Support The Development Of Personalized Nutrition Approaches To Type 2 Diabetes Management, Danielle J Lee, Shragvi Balaji, Jerome I Rotter, Alexis C Wood

Faculty, Staff and Students Publications

Diet is a major modifiable risk factor for type 2 diabetes (T2D), and suboptimal diets continue to contribute substantially to the population burden of T2D. Personalized nutrition proponents argue that specializing recommendations to interindividual differences in diet-health relationships will yield reductions in disease risk. However, how to personalize diet, and to whom, to reduce T2D risk remains unclear. Metabolites offer promise in this respect, as they capture (in part) dietary intake after the processes of digestion, processing, and absorption. The incorporation of metabolite data into diet-health studies therefore offers the opportunity to examine how the effects of food on the …


The Impact Of Utilizing Injectable Platelet-Rich Fibrin And Collagen Plugs For Maintaining The Tooth Extraction Socket: A Review Study, Esraa Hameed Hassan, Ali H. Abbas Alhussaini Jul 2025

The Impact Of Utilizing Injectable Platelet-Rich Fibrin And Collagen Plugs For Maintaining The Tooth Extraction Socket: A Review Study, Esraa Hameed Hassan, Ali H. Abbas Alhussaini

Al-Esraa University College Journal for Medical Sciences

Tooth extraction initiates a cascade of biological changes that result in alveolar bone resorption, compromising both the esthetic and functional outcomes of future dental rehabilitations, particularly implant placement. Socket preservation strategies have emerged as crucial interventions aimed at minimizing post-extraction ridge collapse. This review explores the synergistic effects of injectable platelet-rich fibrin (I-PRF) and collagen plugs in enhancing socket preservation outcomes. Collagen plugs serve as biocompatible scaffolds, promoting hemostasis, cellular migration, and angiogenesis, while supporting soft tissue healing and bone regeneration. Concurrently, I-PRF-an autologous, growth factor-rich biomaterial-provides a dynamic reservoir of platelets, leukocytes, and key cytokines such as Platelet-Derived Growth …


Impact Of Insulin Resistance In Pcos (Lh/Fsh) In A Group Of Woman In Baghdad City, Roua Shehab-Aldeen Ahmed, Fatima Amer Abd Aljabar, Nadia Mohammed Mahdi Al-Shakir Jul 2025

Impact Of Insulin Resistance In Pcos (Lh/Fsh) In A Group Of Woman In Baghdad City, Roua Shehab-Aldeen Ahmed, Fatima Amer Abd Aljabar, Nadia Mohammed Mahdi Al-Shakir

Al-Esraa University College Journal for Medical Sciences

Background: Polycystic ovarian syndrome is an endocrinological disorder influencing ladies, and it is the foremost common cause of menstrual unsettling influence amid the regenerative age. Polycystic ovary disorder (PCOS) is in fact a chronic form of anovulation that is usually observed besides a large spectrum of clinical symptoms and signs. Objectives: The study's main goal is to evaluate the hormonal indicators of ``PCOS'' and insulin resistance and determine how insulin resistance affects these hormones. Materials and methods: This study included 130 women, aged 19--38, who were separated into three bunches: 40 women with ``PCOs'' who were treated with metformin and …


Exploring The Role Of Hepcidin And Some Biochemical Indicators In Β-Thalassemia Major Patients With Negative And Positive Entamoeba Histolytica, Jafar Jamal Abdullah, Mohammed Mezher Hussain, Abdul Rasool Kh. Saeed Jul 2025

Exploring The Role Of Hepcidin And Some Biochemical Indicators In Β-Thalassemia Major Patients With Negative And Positive Entamoeba Histolytica, Jafar Jamal Abdullah, Mohammed Mezher Hussain, Abdul Rasool Kh. Saeed

Al-Esraa University College Journal for Medical Sciences

Thalassemia syndromes encompass a wide range of hemoglobin disorders characterized by either the absence or diminished production of normal globin chains. Hepcidin, a peptide produced by the liver with antimicrobial properties, is mainly synthesized by hepatocytes situated near the portal veins, which are responsible for transporting dietary iron, as well as by Kupffer cells. Before blood transfusions, increased erythropoietic activity leads to a reduction in hepcidin, resulting in lower hepcidin levels that enhance the absorption of dietary iron. Parasite protozoa depend on iron for their survival, as it plays a crucial role in the growth and enzymatic functions of E. …


Full Issue Jul 2025

Full Issue

Digressions: Literary & Art Journal

No abstract provided.


Crochet Fairy Batman, Sammantha Lopez-Guarin Jul 2025

Crochet Fairy Batman, Sammantha Lopez-Guarin

Digressions: Literary & Art Journal

Artist Statement

"The dark knight, the man, the legend, Batman only with a little bit of flare and a lot of style! Coming at you in all shades of pink and a tutu, he's here to help you."


The Artists Is A Sadist, Brianna Calderon Jul 2025

The Artists Is A Sadist, Brianna Calderon

Digressions: Literary & Art Journal

Artist Statement

"'The Artist Is A Sadist' explores the intersection of artistic creation, suffering, and control. As someone balancing a rigorous science curriculum, research demands, and external expectations, I grew frustrated when art was dismissed as a ‘break’ or an ‘easier’ pursuit. Cause in reality, creativity is difficult—creation is painful, even cruel, but it’s a necessary cruelty. This piece depicts a girl stabbing herself in the abdomen like a martyr while maintaining composure, ready for an audience that underestimates the discipline and depth of art. Through this work, I wanted to confront the uncomfortable truth of being a student torn …


Legacy Nutrient Transport By Overland Sheet Flow, John E. Gilley, Ryan P. Mcgehee, Kenneth M. Wacha Jul 2025

Legacy Nutrient Transport By Overland Sheet Flow, John E. Gilley, Ryan P. Mcgehee, Kenneth M. Wacha

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The transport of phosphorus (P) and nitrogen (N) from sites containing varying quantities of legacy nutrients was evaluated in this investigation. The data that were examined were collected during four previously reported field hydrologic studies performed in eastern Nebraska. Additional flow was introduced to the top of the rainfall simulation plots to replicate runoff conditions occurring along a hillslope. It was observed that both P and N delivery were influenced by runoff rate on sites where beef cattle manure or inorganic fertilizer had been applied. Legacy nutrient delivery appeared to have been influenced by the quantity of nutrients released at …


Illuminating The Role Of Vegfa And Egfr In Head And Neck Squamous Cell Carcinoma Through The Multi-Omics Data Integration, Alaa S. Alhegaili, Mohammed Alissa, Abdullah Alghamdi Jul 2025

Illuminating The Role Of Vegfa And Egfr In Head And Neck Squamous Cell Carcinoma Through The Multi-Omics Data Integration, Alaa S. Alhegaili, Mohammed Alissa, Abdullah Alghamdi

Saudi Medical Journal

Objectives: To investigate the functions of 2 crucial wound-healing genes, vascular endothelial growth factor-A (VEGFA) and epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma (HNSCC). Methods: This observational study, carried out between January and August 2024 in Saudi Arabia, involved 20 HNSCC and 10 normal oral cell lines sourced from The American type culture collection. Cell lines were cultured and gene expression was analyzed via RT-qPCR and Western blotting. Promoter methylation and mutational analyses were carried out using databases like UALCAN and cBioPortal. Functional assays, including cell proliferation, colony formation, and wound healing, were carried out …


Effectiveness Of Dupilumab In Chronic Rhinosinusitis With Nasal Polyps: A Retrospective Study Of Clinical And Imaging Outcomes, Mohammed A. Alhejaily, Musallam Kashoob, Shatha Y. Alghamdi, Muhannad A. Alomar, Yazeed A. Alomar, Rawan S. Alzayed, Amany M. Altoies, Ahmad Alroqi Jul 2025

Effectiveness Of Dupilumab In Chronic Rhinosinusitis With Nasal Polyps: A Retrospective Study Of Clinical And Imaging Outcomes, Mohammed A. Alhejaily, Musallam Kashoob, Shatha Y. Alghamdi, Muhannad A. Alomar, Yazeed A. Alomar, Rawan S. Alzayed, Amany M. Altoies, Ahmad Alroqi

Saudi Medical Journal

ABSTRACT Objectives: To evaluate dupilumab’s outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP) cases. Methods: A retrospective analysis was carried out at Dr. Sulaiman Al Habib Hospitals, Riyadh, Saudi Arabia on 145 adult CRSwNP patients treated with dupilumab between January 2020 and December 2023 following the European position paper on rhinosinusitis and nasal polyps 2020 guidelines. Primary outcomes included changes in Lund-Mackay computed tomography (CT) scores, immunoglobulin E levels, and visual analog scale (VAS) smell score over +12 months. Results: Significant improvements were noted post-treatment. Lund-Mackay CT scores decreased from 12.5 to 5.5 ( p <0.001), and VAS smell scores dropped from 10.0 to 0.0 ( p <0.001). Immunoglobulin E levels reduced from 250.5 to 63.5 ( p <0.001). After treatment, 93.3% of patients avoided sinus surgery, 78.6% reported improved asthma status, and 60% used dupilumab as monotherapy. Conclusion: This study supports dupilumab’s effectiveness in treating severe CRSwNP, showing significant improvements in CT imaging and overall medical condition over 12 months. Dupilumab reduced systemic corticosteroid use and rescue surgeries. While promising, further trials are needed to validate its use as monotherapy. Identifying those who gain most from biologic therapy is crucial.


What Approaches Can A Preschool Teacher Use To Support Their Students’ Emotional Regulation Skills?, Lydia Caldwell Jul 2025

What Approaches Can A Preschool Teacher Use To Support Their Students’ Emotional Regulation Skills?, Lydia Caldwell

School of Education and Leadership Student Capstone Projects

Emotional regulation is a foundational skill in early childhood, closely linked to social skill development, mental well-being, and long-term academic success. Throughout this paper, researcher Lydia Caldwell explores the following question: what approaches can a preschool teacher use to support their students’ emotional regulation skills? Drawing from both literature and personal classroom experiences, this project was created with the author’s profession in mind. As a special educator who works with preschool students, Caldwell sees firsthand the amount of children struggling with emotional regulation, also referred to as self-regulation. The project will result in a series of flyers which serve as …


Solid Waste Education For Fourth Grade Students In Washington County, Minnesota, Jessica Hall Jul 2025

Solid Waste Education For Fourth Grade Students In Washington County, Minnesota, Jessica Hall

School of Education and Leadership Student Capstone Projects

The topic of environmental education has grown in recent years, but this study discovered that there is a lack of education focused on solid waste. Four key themes were explored in the current literature: climate anxiety, place-based education, social-emotional learning, and behavior change. This paper is not a research study, but rather a summary of previous research with a discussion of the current situation supporting the need for, and process of, this project’s development. The guiding questions for developing this project are: How can 4th-grade students and teachers in Washington County, Minnesota, perceive the impact of solid waste education lessons …


Adult English As A Second Or Other Language Peer Oral Interaction In Online Breakout Rooms, Kathleen Moriarty Jul 2025

Adult English As A Second Or Other Language Peer Oral Interaction In Online Breakout Rooms, Kathleen Moriarty

School of Education and Leadership Student Capstone Projects

Peer interaction is essential for adult English as a Second or Other Language (ESOL) students' oral skills development. However, it is more challenging to offer peer interaction in online synchronous classes. To support new teachers who begin online teaching, the author reviewed research on peer learning and online classroom interactional competencies. Based on a foundation of second language acquisition theories and communicative teaching practices, oral skills are developed more with specific types of activities in online breakout rooms: task-based, cooperative, and collaborative activities. These activities are inherently social and motivate learners to engage in negotiation for meaning and a focus …


Middle School Science Inquiry-Based Learning On A Budget, Rosalie Olander Jul 2025

Middle School Science Inquiry-Based Learning On A Budget, Rosalie Olander

School of Education and Leadership Student Capstone Projects

This curriculum project was based on the question, “How can science educators teach middle school students while promoting quality inquiry-based learning with a minimum budget?” It was inspired by budget constraints forcing teachers to spend personal funds ($500-$750 annually) on classroom supplies. Science teachers are particularly impacted due to specialized equipment needs, and quality inquiry-based learning is often sacrificed due to cost limitations. The curriculum created as part of this project was written with the framework of Pedaste et al.'s (2015) inquiry phases, the National Research Council's (2012) A Framework for K-12 Science Education, and Wiggins and McTighe's (2011) Understanding …


Incorporating Cooperative Learning And Active Listening Skills In Secondary-Level Science Classrooms, Kaveri Kamatgi Jul 2025

Incorporating Cooperative Learning And Active Listening Skills In Secondary-Level Science Classrooms, Kaveri Kamatgi

School of Education and Leadership Student Capstone Projects

Middle school students are in a key stage of developing their social and emotional skills. Research emphasizes the importance of focusing on effective instructional strategies to support and enhance that development. In science classrooms, this means providing opportunities for cooperative learning and active listening skills, enabling students to interact and consider diverse perspectives while working in lab investigations, problem-based activities, or research projects. According to the NGSS framework for K-12 science education, students are expected to engage in scientific practices that foster scientific thinking skills. To support the development of these skills, this capstone project explored the question: How can …


Not Lost In Translation: Bridging Life Science And Language Acquisition For El Learners, Marlene Gutierrez Becerra Jul 2025

Not Lost In Translation: Bridging Life Science And Language Acquisition For El Learners, Marlene Gutierrez Becerra

School of Education and Leadership Student Capstone Projects

This project seeks to answer the question: How can science educators meet the demands of English language (EL) learners by pairing science instruction with language learning strategies? This project was developed out of the author’s own experience working with EL populations in a science setting and with the goal to provide multilingual students with language learning opportunities that also challenge them and guide them to achieving the MN State Science Standards. The author consulted research that focused on language learning strategies, culturally relevant teaching, and storytelling - based units. Using the information gathered, a website was created containing an introductory …