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2025

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Towards An Indigenous Climate Epistemology: Bringing The Newa Literary Tradition Of The Swasthani Vrata Katha In Conversation With The Festival Tradition Of The Macchindra Nath Jatra, Shangrila Joshi Dr. Jul 2025

Towards An Indigenous Climate Epistemology: Bringing The Newa Literary Tradition Of The Swasthani Vrata Katha In Conversation With The Festival Tradition Of The Macchindra Nath Jatra, Shangrila Joshi Dr.

Critical Humanities

This paper brings into conversation two Newa cultural traditions to articulate notions of climate adaptation, resilience, and mitigation, to illustrate how ways of knowing, ways of being, and ways of governing are inherently linked. These articulations offer a framework for developing what the author calls an Indigenous Climate Epistemology. The two cultural traditions reviewed include: a 17th century Newa literary tradition that advocates for keeping oil in the ground, and that instructs ordinary people to engage in ritual acts seemingly designed to develop personal and community resilience; and a 1700 year old annual community festival designed to avert catastrophes …


The Radical Potential Of Ecopoetics: Ecological Intimacy In Forrest Gander’S Twice Alive, Thomas Storey Jul 2025

The Radical Potential Of Ecopoetics: Ecological Intimacy In Forrest Gander’S Twice Alive, Thomas Storey

Critical Humanities

Ecopoetics is a contested term, one defined by its capaciousness. Through its focus on deep ecology, it draws together the world system and the individual, the collective and the singular, and the global and the placed-based within its dialectical framework, without resolving any of these oppositions. Instead, the apparent contradictions underlying ecopoetics offer productive material for a poetic praxis that aims to foreground the complex connections that string together nature, culture, politics, and society. Forrest Gander’s Twice Alive engages with these contradictions in an attempt to foreground the intimacy of ecological thinking, and its basis in personal connections that are …


The Astrobiological Figure Of Humboldt As Pioneer In The Rock Varnish Research, Jose Jordan-Soria Jul 2025

The Astrobiological Figure Of Humboldt As Pioneer In The Rock Varnish Research, Jose Jordan-Soria

Homage to Alexander von Humboldt: Travels to and from Spain Throughout the Centuries / Homenaje a Alexander von Humboldt: Viajes hacia y desde España de todos los siglos

From Humboldt is particularly interesting -and little know- his description of mineral coatings on rocks 200 years ago, reported in his book Personal Narrative of Travels to the Equinoctial Regions of the New Continent during the years 1799-1804, co-written with Aimé Bonpland, for which is considerate the father of rock coating research. On June 5th 1799 set sail from A Coruña -Spain- to Cumaná -Venezuela- beginning five years of expedition. While they explored the Orinoco River system, in th eriver basin waterfalls, Humboldt observed the presence of dark coating depositions. He ascertained a manganese-rich accretion, reporting similar structures in other …


Harnessing Environmentally Healthy Approaches For Plastic Degradation: A Review And Future Perspectives, Marc Chojnacki Jul 2025

Harnessing Environmentally Healthy Approaches For Plastic Degradation: A Review And Future Perspectives, Marc Chojnacki

Beyond: Undergraduate Research Journal

In the face of escalating plastic pollution, innovative degradation strategies, such as enzymatic degradation, smokeless incineration technology, and biodegradable plastics, are gaining traction. This paper collates comprehensive research on these methods, assessing their environmental impact and operational feasibility. A special focus is placed on the role of technology and its capacity to spark advancements in these degradation strategies as well as to draw on specific research to understand the economic implications of these methods. At the core of this study is the exploration of potential new, inventive degradation methodologies. Through examining methods of green plastic degradation, the study aims to …


Comparison Of Autograft, Allograft, And Conduits For Peripheral Upper Extremity Nerve Repair A Critical Review Of The Current State Of Bone Grafting In Orthopaedic Surgery, Samantha Meacock Jul 2025

Comparison Of Autograft, Allograft, And Conduits For Peripheral Upper Extremity Nerve Repair A Critical Review Of The Current State Of Bone Grafting In Orthopaedic Surgery, Samantha Meacock

Bone Bulletin

Introduction

Several mechanisms of injury can cause peripheral nerve injury (PNI) and subsequent impaired quality of life with loss of motor and/or sensory function. Trauma is a common cause of injury with the most commonly injured nerves being the radial (53%), ulnar (32%), and median nerves (15%).1 The preferred treatment for PNI is reconnecting severed nerve ends anatomically with tension-free end-to-end direct nerve repair of healthy fascicles. However, if the nerve ends cannot be brought together without tension, gapping can occur, and a direct tension-less repair is not possible.5 In the case of a lengthy nerve gap, a …


Implementing A Sustainability Approach By Converting Plastic Bottle Waste From A Mischievous Substance To A Beneficial Material By Means Of Zero Residue Level Concept, Younus Mohammed Abed, Fatima Allawi, Shahad Mudhafar Ali, Salem Jawad Alhamd, Thekra Atta Ibrahim, Mohammed Nsaif Abbas Jul 2025

Implementing A Sustainability Approach By Converting Plastic Bottle Waste From A Mischievous Substance To A Beneficial Material By Means Of Zero Residue Level Concept, Younus Mohammed Abed, Fatima Allawi, Shahad Mudhafar Ali, Salem Jawad Alhamd, Thekra Atta Ibrahim, Mohammed Nsaif Abbas

Karbala International Journal of Modern Science

Plastic waste represents a serious environmental and health hazard due to its non-biodegradability and toxic leachates. This study investigates the potential conversion of plastic waste into a sustainable raw material for producing a useful substance. This investigation focuses on repurposing PET beverage bottles—a major contributor to microplastic pollution—into high-value activated carbon (AC) for water treatment, aligning with circular economy principles. The chemical preparation method for AC using phosphoric acid as an activating agent was evaluated. Results demonstrated the successful conversion of 68% of plastic waste into AC under the following conditions: pyrolysis temperature of 700°C, pyrolysis time of 7 hours, …


Late Onset Malignant Metastatic Transformation Of Benign Pheochromocytoma, Maha Zafar, Reshly Mary Rajan, Manaswini Krishnakumar, Aswanth Reddy Jul 2025

Late Onset Malignant Metastatic Transformation Of Benign Pheochromocytoma, Maha Zafar, Reshly Mary Rajan, Manaswini Krishnakumar, Aswanth Reddy

Journal of Community Hospital Internal Medicine Perspectives

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from adrenal medulla and extra-adrenal paraganglia. Metastatic pheochromocytomas, pose diagnostic and therapeutic challenges due to their atypical presentations and potential for malignant transformation years after primary tumor resection. We report a case of 61-year-old woman who presented with intermittent cough, shortness of breath, and elevated blood pressure 6 years after resection of primary adrenal pheochromocytoma. Imaging revealed bilateral pulmonary nodules, a retroperitoneal mass, and L4 vertebral involvement, raising suspicion for metastatic pheochromocytoma. Elevated serum metanephrines and normetanephrines, alongside tissue biopsy and MIBG imaging, confirmed diagnosis. Germline genetic testing did not reveal …


An Unusual Presentation Of Iga Vasculitis And Iga Nephropathy: A Case Report, Mark A. Colantonio, Nicholas Condiles, Alan P. Lim, Khaled Shawwa Jul 2025

An Unusual Presentation Of Iga Vasculitis And Iga Nephropathy: A Case Report, Mark A. Colantonio, Nicholas Condiles, Alan P. Lim, Khaled Shawwa

Journal of Community Hospital Internal Medicine Perspectives

Immunoglobulin A (IgA) nephropathy is the most common glomerulonephritis worldwide. While IgA nephropathy mainly presents with renal manifestations, systemic symptoms associated with vasculitis are uncommon. Oftentimes, creatinine is used as a serum marker for renal dysfunction; however, it may not always be sensitive, especially in patients with low muscle mass. In such cases, cystatin C may prove to be a better indicator of renal function. Here, we present a case of IgA nephropathy with a normal serum creatinine and elevated cystatin C, highlighting the utility of cystatin C in the setting of a normal creatinine and high suspicion for renal …


Pulmonary Mycobactetrium Kumamotonense With Hepatosplenic Dissemination In An Immunocompetent Patient: A Case Report And Review, Michael S. Wang, Jeremiah Chang, Tiffany Whelan, Bo Liu, Katie Fitton, Jeffrey J Grondin Jul 2025

Pulmonary Mycobactetrium Kumamotonense With Hepatosplenic Dissemination In An Immunocompetent Patient: A Case Report And Review, Michael S. Wang, Jeremiah Chang, Tiffany Whelan, Bo Liu, Katie Fitton, Jeffrey J Grondin

Journal of Community Hospital Internal Medicine Perspectives

We report a 69-year-old with a past medical history of prostate cancer and arsenic poisoning, who was incidentally found to have multiple pulmonary nodules and hepatosplenic lesions on CT imaging. He denied respiratory symptoms, but was noted to have significant weight loss. A bronchoscopy revealed mycobacterium kumamotonense on culture. He was treated presumptively for pulmonary and disseminated infection with azithromycin and ethambutol for 16 months, and 12 months of rifabutin after four months of rifampin which was discontinued due to resistance. Patient’s weight loss resolved and CT imaging appeared significantly improved.


Beautifying Our Home On The Plains, July 03, 2025, Tisa Mason Ed.D. Jul 2025

Beautifying Our Home On The Plains, July 03, 2025, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.


Correction: Turn-On Fluorescent Glucose Transport Bioprobe Enables Wash-Free Real-Time Monitoring Of Glucose Uptake Activity In Live Cells And Small Organisms, Monica S. Hensley, David Hutchings, Abdelrahman Ismail, Micaela Rayne Geborkoff, Thomas Werner, Marina Tanasova Jul 2025

Correction: Turn-On Fluorescent Glucose Transport Bioprobe Enables Wash-Free Real-Time Monitoring Of Glucose Uptake Activity In Live Cells And Small Organisms, Monica S. Hensley, David Hutchings, Abdelrahman Ismail, Micaela Rayne Geborkoff, Thomas Werner, Marina Tanasova

Michigan Tech Publications

Correction for “Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms” by Monica S. Hensley et al., RSC Chem. Biol., 2025, 6, 987–995, https://doi.org/10.1039/D4CB00239C.

The authors regret that two contributors, Micaela Rayne Geborkoff and Professor Dr Thomas Werner, were inadvertently omitted from the original author list of this article. Both individuals made significant contributions to the research reported.

Micaela Rayne Geborkoff was involved in the design, planning, and execution of the Drosophila experiments, specifically in the growth and treatment of fruit fly larvae. Professor Dr Thomas Werner provided …


Introduction To Sociology: Interaction And Social Structure, Dr. Marcia Morrison Ph.D. Jul 2025

Introduction To Sociology: Interaction And Social Structure, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the intricate interplay between micro- and macro-sociological perspectives on social interaction, identity, and structure. Through an examination of theoretical approaches such as symbolic interactionism, dramaturgy, and social exchange, it highlights how individuals construct and perform identities within complex webs of social expectations—particularly shaped by factors like race, status, and role dynamics. The discussion extends to the function of social networks in influencing opportunities, notably in the context of employment, underscoring the nuanced role of weak ties. The analysis further delves into the significance of social status, distinguishing between ascribed, achieved, master, and salient statuses, and examines …


Genome-Wide Association Study For Lung Cancer In 6531 African Americans Reveals New Susceptibility Loci, Jinyoung Byun, Younghun Han, Jiyeon Choi, Ryan Sun, Vikram R Shaw, Catherine Zhu, Xiangjun Xiao, Christine Lusk, Hoda Badr, Hyun-Sung Lee, Hee-Jin Jang, Yafang Li, Hyeyeun Lim, Erping Long, Yanhong Liu, Linda Kachuri, Kyle M Walsh, John K Wiencke, Demetrius Albanes, Stephen Lam, Adonina Tardon, Marian L Neuhouser, Matt J Barnett, Chu Chen, Stig Bojesen, Hermann Brenner, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeböller, David C Christiani, Gad Rennert, Susanne Arnold, John K Field, Sanjay Shete, Loic Le Marchand, Geoffrey Liu, Angeline S Andrew, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Fiona Taylor, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Alpa Patel, Xihong Lin, Krista A Zanetti, Curtis C Harris, Stephen Chanock, James Mckay, Ann G Schwartz, Rayjean J Hung, Christopher I Amos Jul 2025

Genome-Wide Association Study For Lung Cancer In 6531 African Americans Reveals New Susceptibility Loci, Jinyoung Byun, Younghun Han, Jiyeon Choi, Ryan Sun, Vikram R Shaw, Catherine Zhu, Xiangjun Xiao, Christine Lusk, Hoda Badr, Hyun-Sung Lee, Hee-Jin Jang, Yafang Li, Hyeyeun Lim, Erping Long, Yanhong Liu, Linda Kachuri, Kyle M Walsh, John K Wiencke, Demetrius Albanes, Stephen Lam, Adonina Tardon, Marian L Neuhouser, Matt J Barnett, Chu Chen, Stig Bojesen, Hermann Brenner, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeböller, David C Christiani, Gad Rennert, Susanne Arnold, John K Field, Sanjay Shete, Loic Le Marchand, Geoffrey Liu, Angeline S Andrew, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Fiona Taylor, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Alpa Patel, Xihong Lin, Krista A Zanetti, Curtis C Harris, Stephen Chanock, James Mckay, Ann G Schwartz, Rayjean J Hung, Christopher I Amos

Faculty, Staff and Student Publications

Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and mortality rates among different ethnic groups in the United States. Non-Hispanic African Americans had a high incidence rate of lung cancer at 55.8 per 100 000 people, as well as the highest death rate at 37.2 per 100 000 people from 2016 to 2020. While previous genome-wide association studies (GWAS) have identified over 45 susceptibility risk loci that influence lung cancer development, few GWAS have investigated the etiology of lung cancer in African Americans. To address this gap in knowledge, we conducted GWAS of lung cancer …


Effects Of Self-Monitoring On Teachers’ Behavior-Specific Praise And Students’ Behavior In A Center-Based Classroom, Samantha Walsh Jul 2025

Effects Of Self-Monitoring On Teachers’ Behavior-Specific Praise And Students’ Behavior In A Center-Based Classroom, Samantha Walsh

Theses

The current study explores the effects of self-monitoring on teachers' use of behavior-specific praise (BSP) and its impact on student behavior in a center-based classroom. Self-monitoring, a cost-effective and time-efficient intervention, has been proven effective in previous research for enhancing educator performance. However, previous studies have often combined self-monitoring with other interventions, leaving a gap in understanding its effects in isolation. This study aims to replicate the work of Justus et al. (2023) by examining the impact of self-monitoring on paraprofessionals in a center-based classroom with students aged 6-10. Using a multiple baseline design across participants, three paraprofessionals were trained …


The Trapping Of Live Neutrophils By Macrophages During Infection, Kelley N Cooper, Marina Terekhova, Barbara Potempa, Ana D'Aubeterre, Jerome Timbol, Si An Chen, Antoine Dufour, Shunying Jin, Maxim N Artyomov, Jan Potempa, Juhi Bagaitkar Jul 2025

The Trapping Of Live Neutrophils By Macrophages During Infection, Kelley N Cooper, Marina Terekhova, Barbara Potempa, Ana D'Aubeterre, Jerome Timbol, Si An Chen, Antoine Dufour, Shunying Jin, Maxim N Artyomov, Jan Potempa, Juhi Bagaitkar

2020-Current year OA Pubs

Neutrophils are highly abundant in the oral mucosal tissues, and their balanced activation and clearance are essential for immune homeostasis. Here, we demonstrate that neutrophils infected with the bacterial pathogen Porphyromonas gingivalis (Pg) are captured alive by macrophages in a manner that bypasses all known receptor-ligand interactions involved in the phagocytosis of either live or dead cells. Mechanistically, upon interaction with Pg, or its protease RgpB (gingipains), live neutrophils undergo rapid remodeling of their proteomes, generating neoepitopes. N-terminomics-based proteomic profiling identified multiple RgpB cleavage sites on several azurophilic granule proteins that are translocated to the surface of live neutrophils via …


Quantum Magnetization Exchange Through Transient Hydrogen Bond Matrix Defines Magnetic Resonance Signal Relaxation And Anisotropy In Central Nervous System, Dmitriy A Yablonskiy, Alexander L Sukstanskii Jul 2025

Quantum Magnetization Exchange Through Transient Hydrogen Bond Matrix Defines Magnetic Resonance Signal Relaxation And Anisotropy In Central Nervous System, Dmitriy A Yablonskiy, Alexander L Sukstanskii

2020-Current year OA Pubs

The integrity of cellular membranes (lipid bilayers) and myelin sheaths covering axons is a crucial feature controlling normal brain structural and functional networks. Yet, in vivo evaluation of this integrity at the nanoscale level of the cellular membranes organization is challenging. Herein we explore the dual property of biological water in Central Nervous System (CNS), as one of the major stabilizing factors of cellular membranes, and the major source of MRI signal. We introduce the Basic Transient Hydrogen Bond (THB) model of the MR signal relaxation due to the quantum spin/magnetization exchanges within the THB Matrix encompassing water molecules and …


Introduction To Sociology: The Family, Dr. Marcia Morrison Ph.D. Jul 2025

Introduction To Sociology: The Family, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the evolving landscape of modern family structures, analyzing their diverse forms, core functions, and the challenges they face within contemporary society. Drawing on recent research and theoretical frameworks, it examines the transformation of parenthood—especially single fatherhood—the shifting definitions of family and kinship, and the influence of family structure on emotional security, socialization, and reproductive roles. The discussion highlights the rise of dual-career households, increased grandparental involvement, the complexities of blended and single-parent families, as well as the growing acceptance of cohabitation and child-free couples. Special attention is given to persistent social problems, such as the cycles …


Introduction To Sociology: Sex And Gender, Dr. Marcia Morrison Ph.D. Jul 2025

Introduction To Sociology: Sex And Gender, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the complex interplay between sex and gender, focusing on how societal structures, historical contexts, and cultural norms shape gender roles and expectations. Drawing on the works of influential theorists such as Margaret Mead and researchers like Maccoby and Jacklin, the discussion distinguishes between biological sex differences and socially constructed gender distinctions. The analysis highlights the pervasive influence of gender socialization through agents such as family, peers, educational institutions, and media, which collectively reinforce stereotypes and stratify opportunities for individuals. The evolution of gender stratification is traced from the post-World War II era to the present, documenting …


Introduction To Sociology: Class And Stratification, Dr. Marcia Morrison Ph.D. Jul 2025

Introduction To Sociology: Class And Stratification, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the intricate dynamics of class, stratification, and social inequality, emphasizing the interplay of wealth, power, and prestige in shaping individual opportunities and societal outcomes. Drawing on foundational theories from Marxist and functionalist perspectives, it examines the mechanisms by which economic and social structures reinforce or challenge class divisions. The analysis extends to the evolution of American economic disparity, particularly during the transformative 1980s, and examines policies aimed at addressing poverty, such as those articulated by Sar Levitan and the implementation of the Social Security Act. Through a nuanced discussion of cultural capital, the role of …


Response Of Various Body Parts Of House Flies, Musca Domestica, To Sucrose, Panchalie B. Gunathunga, Merveille Muyizere, Bethia H. King Jul 2025

Response Of Various Body Parts Of House Flies, Musca Domestica, To Sucrose, Panchalie B. Gunathunga, Merveille Muyizere, Bethia H. King

Faculty Articles, Papers, and Other Scholarship

Insects use multiple body parts, not just their mouth, to taste. Whether a particular body part has a taste function can be determined by examining the morphology or electrophysiological response of its sensilla (sense organs) or by its behavioral response. The present study investigated taste response of each of the three pairs of tarsi, tibiae, femurs, as well as the antennae and wings, in house flies, Musca domestica L. (Diptera: Muscidae). This was done by measuring the proboscis extension response (PER), and in the case of the wings, also the grooming behavior. PER is a visible precursor to consumption. The …


Strategies For Reducing Employee Turnover In Long-Term Care, Eleanor Denise Gaines Jul 2025

Strategies For Reducing Employee Turnover In Long-Term Care, Eleanor Denise Gaines

Walden Dissertations and Doctoral Studies

High employee turnover in long-term care (LTC) facilities contributes to diminished care quality, low staff morale, and increased operational costs. LTC organizational leaders must address high turnover because it disrupts continuity of care, undermines team cohesion, and increases the burden of recruiting and training new staff. This qualitative multiple case study explored strategies used by human resource managers (HRMs) to improve staff retention and morale in LTC settings, motivated by the need to prevent workforce deterioration, enhance competitive advantage, and increase organizational profitability. Grounded in Herzberg’s two-factor theory, the purpose of the study was to identify evidence-based practices that effectively …


Pacific Rxtracts - July 2025, Pacific Rxtracts Jul 2025

Pacific Rxtracts - July 2025, Pacific Rxtracts

Pacific RxTracts

Articles:

  • First Blood Test Approved For the Diagnosis of Alzheimer’s Disease
  • Rare Withdrawal Reaction Prompts Label Update for Common Antihistamines
  • FDA Approves SUSVIMO: Shifting Diabetic Retinopathy Treatment from Monthly Injections to Continuous Therapy
  • Battle Against Resistant Hypertension
  • Two Is Better than One: Obicetrapib and Ezetimibe, a Novel Combination Pill for High Cholesterol
  • Histo-blood Group ABO System Transferase and Venous Thromboembolism Risk
  • GLP-1 Agonists and Thiazolidinedione Combination Therapy in Type 2 Diabetes
  • Dual Pathway Targeting in Type 2 Diabetes: Exploring the Synergy of GLP1- RAs and SGLT2-inhibitors
  • Two Vaccines, One Shot: Combined Immunizations Against COVID-19 and Influenza
  • Mirikizumab: A New Frontier …


Synthesis And Evaluation Of Novobiocin Analogues As Potential Inhibitors Of Polymerase Theta Polθ In Dna Damage And Repair, Mohammed Essam Albuhluli Jul 2025

Synthesis And Evaluation Of Novobiocin Analogues As Potential Inhibitors Of Polymerase Theta Polθ In Dna Damage And Repair, Mohammed Essam Albuhluli

Theses and Dissertations

Killing tumors while leaving normal cells unharmed is the goal of precision cancer therapy, a challenging feat that is enabled by targeting tumor-specific vulnerabilities [1]. Targeting Polθ potentiates PARP inhibitors (PARPi) in specifically killing homology-directed repair (HDR)-deficient tumor cells and re-sensitize PARPi resistant tumor cells [1]. The induced essentiality between Polθ and HDR-deficiency underscores the value of Polθ as a therapeutic target in the context of tumors with HDR genetic mutations [1]. The helicase-like domain (HLD) is a super family 2 (SF2)-type domain with DNA-dependent ATPase activity [1]. We previously discovered that the antibiotic NVB acts as an inhibitor of …


Metabolic Engineering Of Saccharomyces Cerevisiae For De Novo Biosynthesis Of Naringin From D-Xylose, Zhao Yifei, Li Gaoyang, Huang Luhong, Liu Juan, Xiao Zhiqiang Jul 2025

Metabolic Engineering Of Saccharomyces Cerevisiae For De Novo Biosynthesis Of Naringin From D-Xylose, Zhao Yifei, Li Gaoyang, Huang Luhong, Liu Juan, Xiao Zhiqiang

Food and Machinery

[Objective] To explore the biosynthesis method of naringin,a bioactive compound in citrus.[Methods] Engineered Saccharomyces cerevisiae strains for naringenin biosynthesis are constructed through enzyme screening,multi -copy integration,and precursor supply.Subsequently,de novo biosynthesis of naringin from D-xylose is achieved by introducing the naringin biosynthetic pathway and optimizing UDP -glucose supply.[Results]] The optimal flavonoid synthase is identified as PhCHS by screening the key enzymes of the naringenin pathway.The naringenin biosynthesis pathway is further integrated at multi -copy sites.The constructed strain Z39M2 can synthesize 36.53 mg/L naringenin.The overexpression of CAT 2,xPK-PTA pathway,and ACC 1m optimizes malonyl -CoA supply and constructs strain Z 44,with a naringenin …


Online Detection Of Citrus Sugar Content Based On Visible Near-Infrared Reflectance Spectroscopy, Li Liqiao, Gao Zongyu, Shi Ruyi, Nie Jing, Chai Jianmin, Liu Wei Jul 2025

Online Detection Of Citrus Sugar Content Based On Visible Near-Infrared Reflectance Spectroscopy, Li Liqiao, Gao Zongyu, Shi Ruyi, Nie Jing, Chai Jianmin, Liu Wei

Food and Machinery

[Objective] To lower the complexity,improve the accuracy and reduce the damage of the detection process of citrus sugar content.[Methods] An online detection device for citrus sugar content is designed based on visible near -infrared reflectance spectroscopy.With Jinniu Citrus as the research object,the modeling set and verification set are divided by sample set partitioning based on the joint x-y distance (SPXY ) classification method.The partial least square regression (PLS) modeling and detection effects after pretreatment are respectively compared and analyzed by methods including multiple scattering correction (MSC ),standard normal variation (SNV ),and SG -smoothing (SG) to determine the optimal pretreatment method.At …


Research Progress On Active Components In Fruits Of Panax Plants And Its Processing And Utilization, Kong Linghui, Chen Haining, Wang Yingxiu, Jiang Mengmeng, Li Xiangguo, Han Lianhua Jul 2025

Research Progress On Active Components In Fruits Of Panax Plants And Its Processing And Utilization, Kong Linghui, Chen Haining, Wang Yingxiu, Jiang Mengmeng, Li Xiangguo, Han Lianhua

Food and Machinery

The fruits of Panax species can serve as raw materials for functional foods and as resources for drug development.Their extracts have achieved preliminary translational applications in the fields of health food and medicine,demonstrating market potential.This article selects five Panax species commonly used in clinical practice,including P.ginseng C.A.Mey.,P.quinquefolium L.,P.notoginseng (Burk.) F.H.Chen,P.japonicus C.A.Mey.,and P.japonicus C.A.Mey.var.major (Burk.) C.Y.Wu et K.M.Feng,and systematically elaborates on the research progress regarding the bioactive components,medicinal value,and current status of development and utilization of their fruits.


Amino Acid Transporter Lat1 (Slc7a5) Promotes Metabolic Rewiring In Tnbc Progression Through The L-Trp/Qprt/Nad+ Pathway, Margot Y. Fedoroff, Lei Zhao, Shaomin Wang, Alok Bhushan, Haifeng Yang, Karen M. Bussard, Stephen C. Peiper, Jun He Jul 2025

Amino Acid Transporter Lat1 (Slc7a5) Promotes Metabolic Rewiring In Tnbc Progression Through The L-Trp/Qprt/Nad+ Pathway, Margot Y. Fedoroff, Lei Zhao, Shaomin Wang, Alok Bhushan, Haifeng Yang, Karen M. Bussard, Stephen C. Peiper, Jun He

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Cancer cells uptake excessive nutrients by expressing higher levels of glucose and/or amino acid transporters to meet their increased energy demands. L-type amino acid transporter 1 (LAT1), is regarded as a cancer-specific transporter for the uptake of large neutral amino acids such as L-tryptophan. However, the mechanism by which LAT1 rewires cellular metabolism to promote cancer progression and chemoresistance have not yet been investigated.

METHODS: The protein levels of LAT1, p-PKM2, and p-LDHA were determined in breast cancer tissue arrays by immunohistochemistry staining followed by survival analysis. The orthotopic breast cancer models in mice, syngeneic breast cancer models, and …


Parkinson Disease Signaling Pathways, Molecular Mechanisms, And Potential Therapeutic Strategies: A Comprehensive Review, Muhammad S Khan, Somayyeh Nasiripour, Jean C Bopassa Jul 2025

Parkinson Disease Signaling Pathways, Molecular Mechanisms, And Potential Therapeutic Strategies: A Comprehensive Review, Muhammad S Khan, Somayyeh Nasiripour, Jean C Bopassa

Faculty, Staff and Student Publications

Parkinson's disease (PD) is considered the second most common neurodegenerative disease worldwide; treating this disease remains quite challenging. Environmental and genetic factors may play a role in the pathophysiology of PD. α-synuclein aggregation, oxidative stress, ferroptosis, mitochondrial failure, neuroinflammation, and gut dysbiosis are among the known risk factors of PD. The pathophysiology of Parkinson's disease is complicated by the interconnections between these molecular pathways, which also present significant obstacles to treatment development. However, due to its complex mechanism and long latency, PD is difficult to diagnose and detect, which presents a barrier to treatment. In addition, the need to develop …


Direct Inhibition Of Ras Reveals The Features Of Oncogenic Signaling Driven By Ras G12 And Q61 Mutations, Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa De Stanchina, Scott W Lowe, Richard A Burkhart, Jacquelyn W Zimmerman, Rona Yaeger, Scott E Kopetz, Neal Rosen, Sandra Misale Jul 2025

Direct Inhibition Of Ras Reveals The Features Of Oncogenic Signaling Driven By Ras G12 And Q61 Mutations, Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa De Stanchina, Scott W Lowe, Richard A Burkhart, Jacquelyn W Zimmerman, Rona Yaeger, Scott E Kopetz, Neal Rosen, Sandra Misale

Faculty, Staff and Student Publications

RAS genes are frequently mutated in cancer, often at codons 12 and 61. With the recent introduction of RAS inhibitors, we can now directly investigate the effects of specific RAS mutations in cancer cells. In this study, we demonstrate that in tumors with RASG12X mutations, mutant RAS can be activated by receptor tyrosine kinases (RTK), and PI3K activation is dependent on mutant RAS. Conversely, RASQ61X mutations activate the MAPK cascade independently of RTKs, and inhibition of RASQ61X impairs MAPK pathway activation but leaves the PI3K pathway unaffected. Our characterization of these distinct features of G12X and Q61X mutations suggests that …


Organizational Culture And Work Environment As Determinats Of Teacher Motivation: A Quantitative Study In Slb, Pekalongan Regency, Nur Kholifah, Widya Kusumaningsih, Nurkolis Nurkolis Jul 2025

Organizational Culture And Work Environment As Determinats Of Teacher Motivation: A Quantitative Study In Slb, Pekalongan Regency, Nur Kholifah, Widya Kusumaningsih, Nurkolis Nurkolis

Journal of ICSAR

This study examines the influence of organizational culture and work environment on the work motivation of Special Needs School (SLB) teachers in Pekalongan Regency. Using a quantitative descriptive-correlational approach, data were collected from 103 SLB teachers through a Likert-scale questionnaire. The results show that both organizational culture and work environment have significant and positive effects on teacher motivation, both partially and simultaneously. Organizational culture contributes 46% and work environment 56% to the variation in work motivation, while together they account for 58%. The highest contributions come from intrinsic motivation and the non-physical work environment. These findings emphasize the importance of …