Digital Commons Network^™

Lncrna Mzf1 Antisense Rna 1 Promotes Mycoplasma Pneumoniae Pneumonia In Children Via Mir-16-5p, Qin Wang, Bing Han, Yanan Ji, Cuicui Zhang, Lianying Ruan, Hengrui Hao

Journal of Pediatric Infectious Diseases

Objective: To determine the expression, as well as the underlying mechanism, of lncRNA MZF1 antisense RNA 1 (MZF1-AS1) in Mycoplasma pneumoniae pneumonia (MPP). Methods: GSE179051 was analyzed for differentially expressed lncRNAs in MP infection. The levels of MZF1-AS1 were determined by quantitative Real-time PCR in children with MPP and healthy subjects. The diagnostic value of MZF1-AS1 was assessed using ROC curves. The effects of MZF1-AS1 knockdown on A549, human primary alveolar macrophages (hpAM) and human airway smooth muscle (ASM) cell function were assessed. The downstream miRNA for MZF1-AS1 was predicted and validated. Results: MZF1-AS1 was a differentially expressed lncRNA in …

The Impacts Of Fluconazole On Invasive Fungal Infection, Colonization, And Overall Mortality In Preterm Infants: An Updated Systematic Review And Meta-Analysis, Tiehui Huang, Xue Zhang, Xueqiao Lei

Journal of Pediatric Infectious Diseases

Objective: Invasive fungal infection is not uncommon in preterm infants, and fluconazole has been reported to prevent fungal infection. The impacts of fluconazole on invasive fungal infection in preterm infants can be evaluated using an updated systemic review and meta-analysis of randomized clinical trials. Methods: The log risk ratio was transformed using the risk ratio and 95% confidence interval to assess the impacts of fluconazole on fungal infection in preterm infants. After selection, eleven randomized clinical trials of 1097 preterm infants with fluconazole prophylaxis and 953 preterm infants in the control group were enrolled. The focused outcome was the risk …

Soft-Polymeric Contact Lenses Brands Evaluation According To User Preferences, Lina M. Shaker, Wan Nor Roslam Wan Isahak

AUIQ Technical Engineering Science

The development of soft-polymeric contact lenses (SPCLs) has significantly enhanced vision correction by integrating advanced polymeric materials with optimized optical properties. This study examines the impact of refractive index (RI), oxygen permeability (Dk/t), and water content (EWC%) on visual quality and ocular health, correlating material properties with user-reported experiences. A survey of 5,585 medical SPCL users revealed that 31% experienced ocular fatigue and redness, often linked to optical aberrations and replacement frequency. Notably, commercially available SPCLs exhibit RI values ranging from 1.37 to 1.43, deviating from the natural ocular tissue RI (∼1.33), which contributes to light distortions and reduced visual …

Internet Of Things In Sustainable Agriculture Systems, Ataguba E. Hillary, Ayodeji A. Okubanjo, Nurudeen. S. Lawal, Abisola A. Olayiwola

AUIQ Technical Engineering Science

The agriculture industry has evolved toward intelligent, data-driven processes due to the growing need for food worldwide, environmental sustainability, and effective resource use. A thorough analysis of smart agriculture as a game-changing element of the industry 4.0 revolution is provided in this study, with a focus on the incorporation of Internet of Things (IoT)-based technologies for sustainable farming. To optimize agricultural processes including irrigation, crop health monitoring, climate and weather tracking, animal management, and disease detection, it investigates the functions and uses of smart sensors and IoT devices. The study demonstrates how smart agriculture may meet important issues like food …

Effects Of 25-Hydroxyvitamin D₃ Supplementation As A Partial Replacement For Vitamin D₃ On Laying Performance, Egg Quality, And Bone Traits In Late-Stage Laying Hens, Morakot Nuntapaitoon, Nan Choisunirachon, Somporn Techangvamsuwan, Jiramate Jittidecha

The Thai Journal of Veterinary Medicine

The objective of this study was to assess the impact of dietary 25-hydroxy vitamin D₃ (25OHD₃) supplementation during the late laying hens on egg quality, hen performance and bone computerized tomography (CT) scanning parameters. In total, 24,862 Hy-Line Brownmax hens of 61 weeks old were randomly divided into two groups: the control group (n = 12,368) received a diet containing vitamin D₃ at 3,000 IU/kg, and the treatment group (n = 12,494) received a diet containing vitamin D3 at 1,500 IU/kg and 25OHD₃ at 1,500 IU/kg. The dietary intervention from 61 weeks of age to …

Pollution And Biodiversity Loss: A Comprehensive Review Of Impacts And Mechanisms, Great Iruoghene Edo, Agatha Ngukuran Jikah, Patrick Othuke Akpoghelie, Joseph Oghenewogaga Owheruo, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Arthur Efeoghene Athan Essaghah

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

Biodiversity plays a vital role in maintaining ecological balance and providing essential ecosystem services. However, human activities, including pollution and overexploitation, have led to significant biodiversity loss. Pollution has particularly emerged as a major threat to biodiversity, impacting various species and ecosystems worldwide. This article synthesizes evidence on pollution-driven biodiversity loss, emphasizing industrial, agricultural, and urban sources. We discuss cascading ecosystem impacts and propose mitigation strategies to inform policy making. Overall, the article highlights the importance of addressing the impact of pollution on biodiversity to ensure the preservation of our planet's ecology and the sustainability of our natural resources.

Biosynthesis Of Metallic Nanoparticles Using Plant Extracts: Mechanisms, Advances, And Sustainable Applications, Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Joseph Oghenewogaga Owheruo, Arthur Efeoghene Athan Essaghah

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

Growing concerns over the environmental and health impacts of conventional nanoparticle synthesis have driven a shift toward green, plant-based methods. This review highlights the biosynthesis of nanoparticles using plant extracts as a sustainable, economical and non-toxic alternative. Plant-derived phytochemicals such as flavonoids, phenolics, and alkaloids serve dual roles as natural reducing and stabilizing agents, enabling the production of nanoparticles typically ranging between 10 and 100 nm. Several studies have demonstrated up to 80% yield improvement when using optimized extracts from plants like Azadirachta indica and Ocimum sanctum. The review outlines recent progress, including the use of novel botanical sources, …

Especial Linkage To Poly(Vinyl Chloride) Structure To Enhance Its Characteristics, Amamer M. Redwan

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

Due to a variety of factors that motivated multiple creativities, modification of poly(vinyl chloride) chemical structure has become a flourishing area of research. The current study acts as a condensed overview of the improvements produced using various methods for adjusting the characteristics of poly(vinyl chloride) that is widely utilized. This study explains and emphasizes, through a brief discussion, the findings of the efforts made in recent decades, even if it does not address all of the issues at hand. The article covers a special linkage to the polymer chemical structure such as using heterocyclic moieties to modify poly(vinyl chloride), C–N …

Positive And Negative Parity States Of 226-236th Isotopes, Ali A. Mezban, Falih H. Al-Khudair

Karbala International Journal of Modern Science

The level scheme of the ^226-236Th nuclei is analyzed using the Interacting Boson Model (IBM-1). The ground state band (g. s.-band), beta band (β-band), gamma band (γ-band) have been described in the sd model space. To calculate the negative parity energy levels, the model space is extended to sdf by adding the f-boson (L=3). A sequence of states in energy bands up to 3.5 MeV has been obtained. The decay of negative states below 1 MeV built on an octupole vibration modes is investigated. The transition probabilities in-band and inter-band are calculated using the wave function of the …

Institutional Animal Care And Use Committees And The Challenges Of Evaluating Animal Research Proposals, John J. Pippin, Jarrod Bailey, Mark Kennedy, Debra Dubow Press, Janine Mccarthy, Ron Baron, Stephen Farghali, Elizabeth Baker, Neal D. Barnard

Non-Animal Methods and 3Rs

In the U.S. and many other countries, oversight committee approval is a common requirement for conducting research and publishing its findings. However, in evaluating whether research aims could have been achieved by methods other than the use of animals, these committees face a challenging task. In the U.S., there is no requirement that committee members have expertise in the research areas under review or in methods that could replace animal use, nor could expertise in such vast technical areas be expected. Consideration of alternatives to painful procedures is not required at all for experiments on animals not covered by the …

Transgenerational Imprints Of Sequential Herbivory Onsoybean Physiology And Fitness Traits, Insha Shaft, Rupesh Kariyat

Entomology and Plant Pathology Faculty Publications and Presentations

Sequential herbivory leads to a multitude of effects on plants, influencing processes like growth, physiology, defense, and fitness. However, whether the sequential herbivore attack can elicit any transgenerational consequences is poorly examined. In this study, we show evidence of transgenerational impacts of sequential herbivory by two chewing herbivores, fall armyworm (Spodopterafrugiperda , FAW) and soybean looper (Chrysodeixis includens , SL) on soybean (Glycine max ) progeny. Seeds from the parents subjected to different herbivore sequences (SL-FAW: initial attack by SL followed by FAW and FAW-SL: FAW followed by SL) were used for the transgenerational experiment. Our main hypothesis was that …

Introduction To Sociology: Socialization, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper offers a comprehensive examination of socialization and identity development through a comparative lens, focusing on American, Chinese, and Japanese cultures. It explores how distinct cultural values—individualism, loyalty, and cooperation—shape personal and collective identities from childhood through old age. Utilizing the life course perspective, the analysis considers how factors such as generation, socioeconomic status, race, and gender influence the trajectory of human development. The evolution of childhood is traced across historical and cultural contexts, highlighting shifting perceptions, the impact of industrialization on children's roles, and the persistent influence of class and ethnicity on access to education and well-being. …

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Seeking Into Cell-Free Therapies For Bone-Affected Lysosomal Storage Disorders, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Lysosomal storage disorders (LSDs) constitute a group of monogenic systemic diseases resulting from deficiencies in specific lysosomal enzymes that cause the intralysosomal accumulation of non- or partially degraded substrates, leading to lysosomal dysfunction. In some cases of LSDs, the bone is more severely affected, thus producing skeletal manifestations in patients. Current therapies, such as enzyme replacement therapy (ERT) and gene therapy (GT), show limited efficacy in correcting skeletal abnormalities. Increasing evidence suggests that microenvironmental disturbances also contribute significantly to disease pathogenesis. Therefore, therapeutic strategies targeting lysosomal dysfunction and microenvironmental dysregulation are needed. Mesenchymal stem-cell-derived extracellular vesicles (MSC-EVs) are emerging as …

Evaluation Of Different Resin-Based Barriers In Reducing Microleakage In Restoratively Compromised Posterior Teeth During Rubber Dam Isolation: An Ex Vivo Study, Carolina Becerra, Albert F. Mcmullen Iii, Joon Koh, Thomas E. Lallier

School of Dentistry Faculty Publications

Introduction: The rubber dam has been a standard in endodontic practice for over 140 years, providing critical isolation to prevent microbial contamination during root canal therapy. However, studies indicate that microleakage between the rubber dam and tooth structure may still occur, potentially leading to bacterial infiltration. Various resin-based barriers have been introduced to enhance isolation and minimize leakage. This study aimed to evaluate the efficacy of four resin-based barriers in reducing microleakage during endodontic procedures. Methods: Forty extracted human mandibular molars were selected, stored in distilled water, and standardized for experimental conditions. Standard endodontic access was created, and the mesiobuccal …

Fish Assemblages And Flow Regimes Upstream And Downstream Of Falcon Reservoir, Christopher J. Austin, Christopher Taylor

School of Integrative Biological & Chemical Sciences Faculty Publications

The lower Rio Grande is regulated by Falcon and Amistad dams, as well as series of smaller dams and rock weirs. Several native fish species that rely on a natural flow regime for habitat and spawning are imperiled in the region. We analyzed streamflow discharge above and below Falcon Reservoir to assess potential impacts of dam impoundment on the fishes and flow regime. Fish collections were conducted by seine, and river discharge data was provided by the International Boundaries and Water Commission. We found significant differences in fish assemblages above vs below Falcon Reservoir, and the flow regime was significantly …

Vitamin D Receptor (Vdr) And Autoimmune Diseases, Zahraa M. Al-Taee, Noor Mahommoud Naji, Zeena Hadi Obaid Alwan, Anmar M. K. Al-Maamori, Rasha Kadhim Mahdi

Hilla University College Journal For Medical Science

The vitamin_D_receptor (VDR) has great role in the regulates of expression of gene in several organs, responsive to vitamin D, after activation by physiologically active vit.D. There is strong evidence that vit.D is work in several physiological pathways, since vit.D-activating receptors and enzymes have been found in cell types that are unrelated to mineral and bone homeostasis. Many processes are affected by the so-called non-classic effects of VDR activation. These involve cell death, growth and reproduction of cells, and immune cell activity among many others. Moreover, immunity cells such as activated “CD4+ and CD8+ T cells, B cells, neutrophils, and …

Big Five Personality Traits As Predictors Of Funeral Directors’ Job Satisfaction, Teresa Busick

Walden Dissertations and Doctoral Studies

By 2037, annual deaths in the United States are expected to exceed 3.6 million, over 1 million more than in 2015. At the same time, the funeral service industry faces a serious staffing problem, with about 50% of funeral directors leaving the profession within 2 years. These combined challenges highlight the need to understand what contributes to job satisfaction and helps to retain these workers in this essential field. This quantitative correlational study examined whether the Big Five personality traits predict job satisfaction among funeral directors. Thus, the Big Five model of personality traits was used to guide the study. …

Chromatography In Analysis And Quality Control Of Oil And Gas Products: Modern Approaches And Prospects, Muborak Akramovna Mirshomilova, Natalia Evgenievna Sheina, Lala Bekirova

Technical science and innovation

Chromatography plays a key role in the analysis and quality control of oil and gas products. Modern chromatographic methods, including gas and liquid chromatography, provide high accuracy, sensitivity and speed of analysis. They allow you to identify impurities, control the composition and compliance of products with standards. The article considers innovative approaches, such as multidimensional chromatography and the use of automated systems. Development prospects are discussed, including integration with AI and digital technologies, which opens up new opportunities to improve the efficiency of quality control in the oil and gas industry. This article considers the role of chromatographic methods in …

Development And Characterization Of Pmma/Pvp Nanofiber-Loaded Bioactive Agents With Enhanced Breast Cancer Activity, Samar A. Salim, The British University In Egypt, Esraa Abdelazim, Marwa Abdel Aleem

Nanotechnology Research Centre

Breast cancer remains a leading cause of cancer-related mortality globally, driving the need for novel effective and less toxic therapeutic agents. This study explores the synthesis and characterization of bioactive compounds: 1-(4-methoxyphenyl)-N- (p-tolyl)methanimine (MPTI), N-(4-methylphenyl)benzamide (MPB), and 4-methyl-N-(p-tolyl)benzenesulfonamide (MTS), and their incorporation into a PMMA/PVP polymer matrix for potential anticancer applications. Morphological analysis of the PMMA/PVP-loaded agents via SEM depicts structural modifications in the PMMA/PVP nanofibrous matrix upon incorporation of the bioactive agents. The FTIR analysis of the synthesized compounds before and after loading into the 7PMMA:3PVP nanofibers reveals successful incorporation of MPTI, MPB, and MTS, with characteristic absorption bands …

Pan-Cancer Immune And Stromal Deconvolution Predicts Clinical Outcomes And Mutation Profiles, Bhavneet Bhinder, Verena Friedl, Sunantha Sethuraman, Davide Risso, Kami E Chiotti, R Jay Mashl, Kyle P Ellrott, Jordan A Lee, Christopher K Wong, Kofi Gyan, Aditya Deshpande, Marcin Imielinski, Rohan Bareja, Josh Stuart, Myron Peto, Katherine A Hoadley, Alexander J Lazar, Andrew D Cherniack, Jingchun Zhu, Shaolong Cao, Mark Rubin, Wenyi Wang, Oliver F Bathe, Nicolas Robine, Li Ding, Peter W Laird, Wanding Zhou, Hui Shen, Vésteinn Thorsson, Jen Jen Yeh, Matthew H Bailey, Daniel Cui Zhou, Xianlu L Peng, Mary Goldman, Yongsheng Li, Anil Korkut, Nidhi Sahni, D Neil Hayes, Michael K A Mensah, Ina Felau, Anab Kemal, Samantha Caesar-Johnson, John A Demchok, Liming Yang, Martin L Ferguson, Roy Tarnuzzer, Zhining Wang, Jean C Zenklusen, Paul Spellman, Olivier Elemento

Faculty, Staff and Student Publications

Traditional gene expression deconvolution methods assess a limited number of cell types, therefore do not capture the full complexity of the tumor microenvironment (TME). Here, we integrate nine deconvolution tools to assess 79 TME cell types in 10,592 tumors across 33 different cancer types, creating the most comprehensive analysis of the TME. In total, we found 41 patterns of immune infiltration and stroma profiles, identifying heterogeneous yet unique TME portraits for each cancer and several new findings. Our findings indicate that leukocytes play a major role in distinguishing various tumor types, and that a shared immune-rich TME cluster predicts better …

Experiences Of Managing And Living With Autoimmune Addison’S Disease In The Younger And Newly Diagnosed Adults: An Interpretative Phenomenological Analysis, Mathew Horodner

Walden Dissertations and Doctoral Studies

There is a lack of knowledge regarding the experiences of managing and living with autoimmune Addison’s disease (AD) in the younger and newly diagnosed adults. AD research usually focuses on biological or medication studies. Thus, the purpose of this qualitative study was to understand the lived experiences of the younger and newly diagnosed adults living with autoimmune AD. Consisting of the complex integration of biological, psychological, and social factors, Engel’s biopsychosocial model served as the study’s conceptual framework. I conducted this study to include the experiences of managing and living with autoimmune AD in the younger (18–35) and newly diagnosed …

Seasonal Sea Ice Characterized The Glacial Arctic-Atlantic Gateway Over The Past 750 000 Years, Monica Winsborrow, Pengyang Song, Simon Belt, Jochen Knies, Henning A. Bauch, Lukas Smik, Gerrit Lohmann

School of Geography, Earth and Environmental Sciences

The past occurrence of an extreme ~1-kilometer–thick Arctic Ocean–Nordic Seas ice shelf has been inferred from submarine landscape features and geochemical records, although fundamental aspects of its characteristics, impacts, and timing remain highly debated. Here, we challenge this pan-Arctic glaciation hypothesis by investigating two sites from the Arctic-Atlantic gateway (AAG) and the Nordic Seas. Suborbital to millennial-scale surface water bioproductivity changes provide no evidence for a continuous ice shelf in the AAG and the Nordic Seas over the past ~750,000 years. Instead, proxy data and model simulations reveal the persistent presence of seasonal sea ice cover and open water phytoplankton …

An Optimized Model For Identification Of Cerebral Palsy Using Deep Learning, Anjar Ahsan, Hassan Bin Mohammed, Abhilash Maroju, Nurhafizah Moziyana Mohd Yusop, Wan Su Emi Yusnita Wan Yusof, Najjah Salwa Abd Razak, Mohd Arif Dar

Polytechnic Journal

Cerebral palsy (CP), a neurological disorder that affects children and can occasionally result in cognitive problems as well as deficits in motor function can be caused by prenatal, perinatal, or postnatal factors. Each subtype of cerebral palsy (CP), such as spastic and non-spastic cerebral palsy, has distinct symptoms based on the location of the brain lesion and how it affects muscle tone. Individualized therapy and rehabilitation programs are necessary to treat these differences effectively. Therefore, early-stage CP categorization is crucial to ensuring timely and targeted treatment efforts. The functional magnetic resonance imaging (fMRI) of the infant's brain is a helpful …

Cortical Functional Organization In Early Childhood, Jiaxin Tu

Arts & Sciences Graduate Student Theses and Dissertations

The advent of connectivity-based methods, particularly those utilizing spontaneous BOLD signals, has significantly advanced brain mapping and deepened our understanding of the human brain's functional architecture. While prior research has explored functional organization in early childhood, most studies have focused on coarse, group-level distinctions aligned with adult literature, often within narrow age ranges. This dissertation extends these investigations by examining cortical functional organization in greater detail among healthy infants and toddlers aged 1 to 5 years. Chapter 1 employs spontaneous BOLD signals in sleeping infants and toddlers to derive a group-level functional organization at the resolution of areas and networks. …

Chaperone-Usher Pathway Pili Adhesin Conformations And Inhibitors In Urinary Tract Infections, Edward Lopatto

Arts & Sciences Graduate Student Theses and Dissertations

Antibiotic resistant bacteria are becoming increasingly difficult-to-treat resulting in increased morbidity and mortality, especially for common infections such as urinary tract infections (UTIs). Globally, UTIs afflict over 400 million people a year. Numerous different gram-negative and gram-positive bacterial species cause UTIs, including uropathogenic Escherichia coli (UPEC), Klebsiella pneumoniae, and Acinetobacter baumannii. Many of these bacterial species are listed as pathogens of urgent concern by the Center for Disease Control due to the dangerous rise and prevalence of antibiotic resistance necessitating development of new therapeutic measures. Bacteria utilize adhesin factors, such as chaperone-usher pathway (CUP) pili to gain a foothold in …

Vigorous Physical Activity As A Potential Environmental Risk Factor In Renal Medullary Carcinoma, Daniel D Shapiro, Sagar S Mukhida, Andrew W Hahn, Ayman Isahaku, Schyler M Turner, Jessica P Cheng, Pankaj K Chauhan, Susan S Thomas, Beei Chan, Zita D Lim, Nizar M Tannir, Maria Chang Swartz, Pavlos Msaouel

Faculty, Staff and Student Publications

Purpose: Renal medullary carcinoma (RMC) is a rare but aggressive kidney cancer affecting young individuals with sickle hemoglobinopathies. Prior retrospective case-control and mouse modeling studies suggest a mechanism linking vigorous intensity physical activity to increased RMC risk in individuals with sickle hemoglobinopathies. This study aimed to prospectively investigate the association between vigorous intensity exercise and RMC.

Materials and methods: This study used a validated questionnaire to prospectively assess reported physical activity in a large cohort of patients with RMC compared to the activity of individuals without RMC. Between 2022 and 2024, patients with RMC (N = 39) were prospectively surveyed …

Human Extravillous Trophoblasts Require Src-2 For Sustained Viability, Migration, And Invasion, Vineet K Maurya, Pooja Popli, Bryan C Nikolai, David M Lonard, Ramakrishna Kommagani, Bert W O'Malley, John P Lydon

Faculty, Staff and Students Publications

Defective placentation is a recognized etiology for several gestational complications that include early pregnancy loss, preeclampsia, and intrauterine growth restriction. Sustained viability, migration, and invasion are essential cellular properties for embryonic extravillous trophoblasts to execute their roles in placental development and function, while derailment of these cellular processes is linked to placental disorders. Although the cellular functions of extravillous trophoblasts are well recognized, our understanding of the pivotal molecular determinants of these functions is incomplete. Using the HTR-8/SVneo immortalized human extravillous trophoblast cell line, we report that steroid receptor coactivator-2 (SRC-2), a coregulator of transcription factor-mediated gene expression, is essential …

Mic: A Deep Learning Tool For Assigning Ions And Waters In Cryo-Em And Crystal Structures, Laura Shub, Wenjin Liu, Georgios Skiniotis, Michael J Keiser, Michael J Robertson

Faculty, Staff and Students Publications

At sufficiently high resolution, x-ray crystallography and cryogenic electron microscopy are capable of resolving small spherical map features corresponding to either water or ions. Correct classification of these sites provides crucial insight for understanding structure and function as well as guiding downstream design tasks, including structure-based drug discovery and de novo biomolecule design. However, direct identification of these sites from experimental data can prove challenging, and existing empirical approaches leveraging the local environment can only characterize limited ion types. We present a representation of chemical environments using interaction fingerprints and develop a machine learning model to predict the identity of …

Supporting Patients With Advanced Cancer And Their Spouses In Parenting Minor Children: Results Of A Randomized Controlled Trial, Kathrin Milbury, Sujin Ann-Yi, Meagan S Whisenant, Morgan Jones, Yisheng Li, Victoria Necroto, Sania D Yousuf, Mariana Chavez-Macgregor, Larrisa Meyers, Eduardo Bruera

Faculty, Staff and Student Publications

Introduction: Patients with advanced cancer and their spousal caregivers who parent minor children report unmet parenting concerns and increased psychological distress. Seeking to address these important supportive care needs, this RCT examined the feasibility, acceptability, and initial evidence for the efficacy of a novel psychosocial intervention.

Patients and methods: Patients with a metastatic solid malignancy and their spouses completed self-reported validated assessments of psychological symptoms and cancer-related parenting outcomes and were then randomized to the parent support intervention or a usual care (UC) group. Both groups were reassessed 6 and 12 weeks later. Dyads randomized to the counselor-led intervention attended …

The Human Catalyst And Extractivist Fiction: A Close Reading Of Siddhartha Sarma’S Year Of The Weeds And Pundalik N Naik’S The Upheaval, Elwin Susan John Dr

Critical Humanities

Literary narratives have been abetting the various global faces of climate crisis, ever since the disciplines of humanities and social sciences have become vocal about the Anthropocene. The discussions have been mostly centered around the discourses of capitalism, imperialism, rights and subalterity. By reading some of these foundational grips on ecological crisis, the present essay analyses literary narratives on mining and extraction in India from the standpoint of a human catalyst; which is defined as an entity that can cause a chain reaction, that may or may not result in the annihilation of the initial catalyst. The essay will begin …