Digital Commons Network^™

From Trials To Practice: Implementing A Clinical Intervention In Community Settings, Craig A Johnston, Salim S Virani, Ashok Balasubramanyam, Christie M Ballantyne, Aanand D Naik

Faculty, Staff and Students Publications

Introduction/objectives: Diabetes increases the risk of complications, especially for vulnerable populations. Our previous randomized clinical trial (RCT), TIME (Telehealth-supported, Integrated Community Health Workers (CHWs), Medication access, group visit Education), showed the efficacy of CHW-led diabetes care. This study aimed to gather data on transitioning TIME from clinical trials to practical implementation.

Methods: We conducted a 12-month RCT at a nonprofit community clinic using the Consolidated Framework for Implementation Research (CFIR). Participants, Hispanic adults without insurance and with type 2 diabetes (N = 58; 29/arm), were randomized to TIME (intervention) or usual care (control). The intervention included monthly group visits and …

Comparative Analysis Of Aav Serotypes For Transduction Of Olfactory Sensory Neurons, Anthony M Insalaco, J P Mcginnis, Brandon T Pekarek, Joshua Ortiz-Guzman, Burak Tepe, Hu Chen, Ascent-Pd Investigators, Zhandong Liu, Benjamin R Arenkiel

Faculty, Staff and Students Publications

Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor information to the central nervous system. Unlike other sensory inputs, olfactory sensory neurons interface with the external environment and project their axons directly into the central nervous system. The use of adeno-associated viruses to target these neurons has garnered interest for applications in gene therapy, probing olfactory sensory neuron biology, and modeling disease. To date, there is no consensus on the optimal AAV serotype for efficient and selective transduction of olfactory sensory neurons

Neutrophils Unveiled In Chronic Lymphocytic Leukemia, Sheighlah Mcmanus, Priyanka Khare, Maria Teresa S Bertilaccio

Faculty, Staff and Student Publications

This review explores neutrophils' roles in chronic lymphocytic leukemia (CLL), highlighting their functions within the immune system. While neutrophils are known for fighting infections, their altered behavior in CLL significantly impacts disease progression. This review notes the reduced phagocytic abilities of neutrophils and the increased formation of neutrophil extracellular traps (NETs) in patients with CLL. It also examines the effects of CLL treatments, including chemotherapy, immunotherapy and targeted therapies, on neutrophils' count and function, stressing the need for improved strategies to manage therapy-induced immune dysfunction. This review also provides detailed information about the interactions between neutrophils and other immune elements …

Microbial Imprints On Colorectal Cancer: The Epigenetic Silencing Of Phlpp1 As A Prognostic Nexus, Xiangsheng Huang, Faraz Bishehsari

Faculty, Staff and Student Publications

No abstract provided.

Editorial: Protein Regulation By Lipids, Mikhail V Bogdanov, Elena G Govorunova

Faculty, Staff and Student Publications

No abstract provided.

Micrornas As Key Regulators Of Cancer Drug Resistance: Insights And Future Directions In Chemotherapy, Targeted-Therapy, Radiotherapy, And Immunotherapy, Michael Attathikhun, Ancuta Jurj, George A Calin

Faculty, Staff and Student Publications

Cancer therapy remains an active field of investigation, particularly in understanding and overcoming therapy resistance. Small non-coding RNAs, such as microRNAs (miRNAs), are emerging as key regulators of cancer survival, progression, proliferation, invasion, migration, and metastasis. Although many studies have linked miRNAs to cancer therapy outcomes, significant questions remain regarding their precise molecular and cellular roles in therapy resistance. Increasing evidence shows that miRNAs influence critical pathways such as apoptosis, immune evasion, and other signaling cascades. However, there have been many setbacks because of the limitations in knowledge of each specific miRNA's function. A deeper understanding of miRNA expression and …

Disulfidptosis And Its Emerging Relevance In Cancer And Immunity, Qidong Li, Shengrong Wu, Li Zhuang, Boyi Gan

Faculty, Staff and Student Publications

Disulfidptosis is a recently identified form of regulated cell death (RCD) triggered by disulfide stress when cystine uptake via solute carrier family 7 member 1 (SLC7A11) overwhelms the cell's reducing capacity. Unlike apoptosis or other "cell suicide" pathways, disulfidptosis likely represents a "cell sabotage" mechanism, defined by aberrant disulfide bonding and catastrophic actin cytoskeleton collapse. In this Perspective, we examine the paradoxical role of SLC7A11 as both a ferroptosis protector and a disulfidptosis trigger, and the mechanistic hallmarks of disulfidptosis. We highlight emerging therapeutic strategies to target disulfidptosis in cancer, including glucose transporter inhibition, redox-targeting agents, and nanomaterial-based approaches, and …

Racial And Ethnic Disparities In Longitudinal Trajectories Of Cardiovascular Risk Factors In Us Middle-Aged And Older Adults, Matthew E Dupre, Radha Dhingra, Hanzhang Xu, Scott M Lynch, Qing Yang, Cassie Ford, Michael D Green, Ying Xian, Ann Marie Navar, Eric D Peterson

Faculty, Staff and Student Publications

Background: Racial and ethnic disparities in cardiovascular disease (CVD) risk factors are well-documented. However, racial and ethnic differences in the longitudinal changes among multiple CVD risk factors are unknown.

Methods: We used prospective cohort data of U.S. adults aged ≥50 in the 2006-2016 Health and Retirement Study. Group-based multi-trajectory models characterized age-related trajectories of systolic blood pressure ([BP] mmHg), non-HDL cholesterol (mg/dL), diabetes mellitus (DM), and smoking. Racial and ethnic differences in the multi-trajectory profiles were examined using multinomial logistic regression. Karlson-Holm-Breen methods were used to assess factors contributing to these associations.

Results: Among 10,292 participants (median age: 61), approximately …

Topss: Tolerability Of Transcranial Direct Current Stimulation In Pediatric Stroke Survivors, Stuart Fraser, Anna Clearman, Melika Abrahams, Bernadette Gillick, Tia Lal, Sean Savitz, Nuray Yozbatiran

Faculty, Staff and Student Publications

Background: Transcranial direct current stimulation is a non-invasive neuromodulation technique with emerging therapeutic potential in neurodevelopmental conditions. While childhood-onset stroke survivors frequently experience long-term motor impairment, there are very few studies examining the safety and feasibility of transcranial direct current stimulation in this population.

Objective: To evaluate the safety, feasibility, and tolerability of bihemispheric transcranial direct current stimulation paired with occupational therapy in children and adolescents with chronic hemiparesis following childhood-onset arterial ischemic stroke or intracranial hemorrhage.

Methods: In this single-arm, open-label pilot study, five participants aged 6-19 years of age received five daily sessions of transcranial direct current stimulation …

Introducing Sustainable Development Goals In College Curricula: A Way Forward, Christy Ashley, Jason D. Oliver, Hillary Leonard

Markets, Globalization & Development Review

The commentary proposes a blueprint to help guide curriculum innovations, partnerships, and teaching interventions that incorporate the United Nations sustainable development goals (SDGs) into the curriculum. It suggests the utilization of AACSB’s Societal Impact Canvas with Ancona et al.’s (2007) Leadership Capabilities (Sensemaking, Relating, Visioning, Inventing) to provide a blueprint for mission-aligned SDG integration at a local level. It provides an illustrative example from the University of Rhode Island (USA), where the focus is on the Blue Economy. It aims to provide practical guidance for how a college or university can efficiently organize to gain stakeholder input that helps enhance …

“Flies Don't Make Honey": An Exploration Of Preschoolers’ Feelings And Actions Towards Nature, Kathrin Paal

School of Law, Humanities and Social Sciences Theses

The burgeoning climate crisis resulting from anthropogenically enhanced global warming has made protection, restoration and affection for the environment an increasingly urgent matter. The irresponsible use of resources and pollution has caused, and will continue to cause, disastrous impacts on habitats and ecosystems globally; we urgently need to better care for the natural environment. Children’s perceptions towards nature are formed during early experiences. There is a research gap for age-appropriate methods to understand children’s perspectives whilst conceptualising them as the experts in their own lives and meaningfully enhancing their involvement in research. The aim of this thesis is to explore …

Which Discourses Underpin Long-Term, Autistic/Non-Autistic Romantic Couples’ Understandings Of Their Relationship As They Live With And Accommodate Each Other? A Critical Discourse/Narrative Inquiry, Vivien Southall

School of Law, Humanities and Social Sciences Theses

This piece of work draws on both critical discourse and critical narrative inquiry to examine the long-term romantic relationship experiences of those in autistic/non-autistic long-term romantic relationships. Four couples participated, three heterosexual and one female same-sex couple. The participants were given the opportunity to tell their narratives in a variety of forms, through interviews, emails, stories and with photographs and mementoes as prompts. These forms inspired the way that the data was retold in the research using a variety of styles reflecting the narrative choices of the participants. Through interviews with participants individually and as a couple, over sixteen months, …

Nurturing The Event: A Trauma-Informed Psychosocial Analysis Of Conversions To Christianity And Desistance From Crime, Alex Beaumont

School of Law, Humanities and Social Sciences Theses

The aim of this thesis is to demonstrate the role prison chaplaincy and faith-based organisations play in supporting new Christian converts across HMPPS establishments. Drawing on research data from 11 in-depth narrative interviews with formerly incarcerated individuals, many of whom were long-term desisters or still in the desistance process (18 months post-release), this thesis provides a psychoanalytic interpretation of the relationship between early childhood development, traumatic events, and spiritual transformations in prison. Data was gathered using Hollway and Jefferson’s (2001) Free Association Narrative Interview Method (FANIM), which applies psychoanalytic principles to explore subjectivity beyond surface-level descriptions of self and identity. …

Experiences And Understandings Of Multiculturalism In Mainstream Primary Schools In Southwest England, Suparna Bagchi

School of Law, Humanities and Social Sciences Theses

The present study is an exploration of teachers’, parents’ and students’ experiences and understandings of multiculturalism in four mainstream primary schools situated in a predominantly White location in Southwest England. It adopts qualitative methodology under a single case study design underpinned by a sociocultural theoretical framework. Data were collected from semi-structured interviews conducted virtually with adult participants, students’ classroom activities and field notes supplemented by photographs of classroom and corridor displays. Study findings suggest strong support among participants for incorporating multicultural components in school teaching and learning. Findings also suggest varying levels of accessibility, knowledge and availability of resources around …

Bridging The Divide: How Do Lecturers In Undergraduate Sound Engineering Courses Bridge The Gap Between Industry And Education?, Daniel Tregenna

School of Law, Humanities and Social Sciences Theses

The formal study of sound engineering is a relatively modern and under-researched field within modern arts education. However, this subject has a number of features that are common across a range of subjects of a similar nature. How the lecturers who work on these courses influence students and tie them to the wider industry is potentially pivotal in an industry so intrinsically tied to the nature of interpersonal connections. Particularly where this industry simultaneously does not provide stable and sustained working partnerships. This international comparative study looks to explore the role lecturers on undergraduate sound engineering courses play in bridging …

‘At Least I Wasn't In An Inner-City Flat With A Partner I Hated’: An Auto/Biographical Study Of Reflections On Well-Being By 35-65 Year Olds In Cornwall Following The Covid-19 Pandemic, Cheralyn May

School of Law, Humanities and Social Sciences Theses

The effects of the Covid-19 pandemic on mental health have been considerably researched since its start in 2019, by researchers from a range of disciplines around the world. This sociological study (using insights from social and positive psychology) contributes to our knowledge of the pandemic by using qualitative methods – fourteen semi-structured interviews and researcher auto/biography to investigate the mental health experiences of middle-aged, single adults living in Cornwall in the UK during the pandemic. In the pandemic literature, this is an under-researched, and therefore potentially less understood, group and location. The data was analysed using a combination of the …

Reducing Marine Plastic Pollution: Critical Assessment Of The Potential To Develop A Civil Liability And Compensation Mechanism Under The Law Of The Sea Convention, Alexandra Leaton

School of Law, Humanities and Social Sciences Theses

Plastic pollution has had a detrimental global impact, particularly in the marine environment, due to its mobility, longevity, and tendency to be difficult to retrieve. The situation has worsened because of the increased production and consumption of plastics and the fact that pollution occurs throughout the entirety of plastics’ production and lifecycle. Its pathways/vectors to the marine environment are diffuse and complex. The combined environmental, social, and potential health impacts of plastics have resulted in the development of over 40 international legal and other regulatory mechanisms, although inconsistent implementation has resulted in a fragmented framework with gaps and overlaps. The …

2025 Program, Georgia Southern University

Georgia Educational Research Association Conference

2025 Schedule