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2025

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Larval Environments Affect The Implementation Of The Sterile Insect Technique On Aedes Mosquitoes, Katherine G. Evans Jan 2025

Larval Environments Affect The Implementation Of The Sterile Insect Technique On Aedes Mosquitoes, Katherine G. Evans

Theses and Dissertations

Sterile Insect Technique (SIT) is an effective method for controlling pests and has been increasing in popularity to control Aedes mosquitoes. SIT involves inundating an area with sterilized male mosquitoes to reduce egg hatch and ultimately the number of wild adults. Previous research indicates that enacting mortality early in the larval life of Aedes mosquitoes can result in counter-productive effects, due to reduced competition among developing larvae. I hypothesize that the effectiveness of SIT at reducing adult populations is modified by densitydependent mortality and density-dependent growth among larvae. I performed two field-to-lab studies and developed an individual-based model to test …


Perceptions Of A Hypothetical Student As A Function Of Binge Eating Disorder And Gender, Erin Rose Hennessy Jan 2025

Perceptions Of A Hypothetical Student As A Function Of Binge Eating Disorder And Gender, Erin Rose Hennessy

Theses and Dissertations

Stigma toward those with binge eating disorder and a gender bias toward eating disorders can lead to misattribution of symptoms as well as a reduced likelihood of having the diagnosis of eating disorders (Currin, Schmidt, and Waller 2007). Symptoms of binge eating, such as being overweight, have different social meanings than an eating disorder that can lead to being underweight, such as anorexia (Saguy and Gruys 2010). In addition, social support has been previously found to have positive relationships with eating disorder recovery. The purpose of this study was to understand differences in people’s perceptions of targets who are overweight …


How Latine College Students Experience, Maneuver, And Navigate Within The Colonizing Notion Of Smartness, Jasmine Jetton-Gonzales Jan 2025

How Latine College Students Experience, Maneuver, And Navigate Within The Colonizing Notion Of Smartness, Jasmine Jetton-Gonzales

Theses and Dissertations

This study explores how Latine college students, particularly those who are the first in their family to attend college, navigate and maneuver within the dominating colonizing notion of smartness in academia. Rooted in an Anglo-centric educational framework, the American education system often marginalizes Latine students by devaluing their cultural and linguistic knowledge while upholding Eurocentric standards of intelligence. Using a qualitative critical research approach, this study employs testimonios to examine the lived experiences of Latine college graduates in Illinois. Findings reveal that Latine students frequently encounter systemic barriers that challenge their academic identity, including racialized perceptions of intelligence, institutionalized deficit …


Fueling The Fire! How Black Students Make Sense Of Their Experiences With Youth Development Programs And Their Roles In Post-Secondary Transition And Success, Erica Austin Jan 2025

Fueling The Fire! How Black Students Make Sense Of Their Experiences With Youth Development Programs And Their Roles In Post-Secondary Transition And Success, Erica Austin

Theses and Dissertations

In this dissertation, I used a phenomenological research design to explore how Black students make sense of their experiences with Youth Development Programs (YDPs)and how the program components contributed to their transition and success in postsecondary education. An analysis of the interview data gathered from ten black students through the lens of Social Identity Theory revealed three themes: (a) YDPs help students feel prepared and supported by equipping them with essential academic and life skills, mentorship, and leadership opportunities; (b) Representation within YDPs fosters self-efficacy and aspiration, as mentors and role models who share students’ cultural backgrounds inspire confidence and …


Reframing Equity Gaps: A Descriptive Analysis Of Reported Spending For Underrepresented Minorities At Illinois Community Colleges, Terrance Marshall Bond Jan 2025

Reframing Equity Gaps: A Descriptive Analysis Of Reported Spending For Underrepresented Minorities At Illinois Community Colleges, Terrance Marshall Bond

Theses and Dissertations

This quantitative descriptive analysis investigates reported institutional spending and associated equity gaps for underrepresented minority (URM) students in Illinois community colleges from FY2017-FY2021. Guided by Critical Sensemaking (CSM) theory, the study examines correlations between targeted expenditures and enrollment and completion outcomes for Black and Latinx undergraduate students. Utilizing data from Illinois Community College Board (ICCB) Underrepresented Groups (URG) reports, this research identifies patterns in institutional financial commitments toward equity initiatives, analyzing their relationship to enrollment and completion disparities. Key findings reveal substantial variability in institutional spending directed toward underrepresented minorities, despite statewide mandates and strategic goals focused on reducing equity …


Scrolling For Two: An Exploration Of Pregnant Women's Social Support And Information Seeking Behaviors Using Technology During The Covid-19 Pandemic, Sarah Knowlton Jan 2025

Scrolling For Two: An Exploration Of Pregnant Women's Social Support And Information Seeking Behaviors Using Technology During The Covid-19 Pandemic, Sarah Knowlton

Theses and Dissertations

Pregnant women faced additional challenges in accessing reliable support and pregnancy- related information, leading to increased distress during the COVID-19 pandemic. Quarantine measures limited doctor’s appointments and isolated pregnant women from their families, which meant that meaningful connections and convenient information was important.

The purpose of this study is to explore the implications of COVID-19 social distancing on pregnant women, with a focus on three questions: 1) what digital technologies did pregnant women use for support and information seeking purposes during the pandemic? 2) how did pregnant women use technology to seek social support during the pandemic? 3) how did …


The Tender Flesh: Dwelling In Soft Wounds And Visceral Bodies, Madelyn Irene Turner-Havens Jan 2025

The Tender Flesh: Dwelling In Soft Wounds And Visceral Bodies, Madelyn Irene Turner-Havens

Theses and Dissertations

Within my painting process, I explore bodily interiority and exteriority in relation to the surface of painting, evoking a discomforting sense of corporeal (dis)embodiment, where haunted flesh becomes palpable. Indexing conversations with the body into the painting is a way to understand my body and create an experience of what happens when language fails to capture the complexity of sensation. Painting becomes a mediation with the canvas, a constant discovery of what can give shape to the intangible: how it feels when my skin folds into itself, bodily urges, and the soft texture of fatty tissue.

I let the parts …


“My Pain Was Never More Valuable Than His Potential”: A Rhetorical Thematic Analysis Of Gaslighting Within Sexual Abuse Cases, Makayla Roller Jan 2025

“My Pain Was Never More Valuable Than His Potential”: A Rhetorical Thematic Analysis Of Gaslighting Within Sexual Abuse Cases, Makayla Roller

Theses and Dissertations

This thesis examines gaslighting within three prominent sexual abuse cases—Harvey Weinstein, Matt Lauer, and Larry Nassar—uncovered during the #MeToo movement, to better understand the rhetorical function of gaslighting. Using a combination of rhetorical thematic analysis, critical discourse analysis, a feminist lens, and a gaslighting schema, this study identifies the rhetorical tactics, gendered discourse, and power-laden discourse deployed to gaslight victims and the public. I argue that gaslighting must be examined through a rhetorical lens, as discourse is the mechanism through which gaslighting operates, shaping perceptions of truth, credibility, and power. By highlighting how language is weaponized to deny, distort, and …


A New Theater For Age-Old Social Patterns: An Exploratory Study Of Interpersonal Dynamics And The Overlay Of Gender Within Ai Companionship, Miriam Wolff Jan 2025

A New Theater For Age-Old Social Patterns: An Exploratory Study Of Interpersonal Dynamics And The Overlay Of Gender Within Ai Companionship, Miriam Wolff

Theses and Dissertations

The emergence of artificial intelligence (AI) companions fundamentally shifts the landscape of interpersonal communication, introducing artificial entities as relational partners rather than mere facilitators of human-to-human interaction. This exploratory study examines the interplay of machine gendering, self-disclosure, perceived partner responsiveness (PPR), and interpersonal satisfaction within human-AI interactions. Participants engaged in conversations with gendered AI companions through the program Replika, completed structured surveys, and participated in qualitative interviews. Findings indicate that users' willingness to self-disclose was influenced by their perceptions of AI responsiveness, while gendered characteristics of AI significantly shaped user expectations and communication patterns. Specifically, users often attributed distinct personality …


Enhancing Climate Change Awareness In Children Through Augmented Reality: A Study On Educational Engagement., Jubair Islam Jan 2025

Enhancing Climate Change Awareness In Children Through Augmented Reality: A Study On Educational Engagement., Jubair Islam

Theses and Dissertations

As the need to address climate change becomes more urgent, introducing children to environmental conservation has become increasingly important. This thesis explores how augmented reality (AR) technology can turn traditional storytelling into an exciting and educational experience to help children learn about climate change. Sam and Mia’s Earth-Saving Adventure, a 10-page graphic storybook enhanced with AR, allows children aged 3-10 to interact with the story through animations and sound effects that respond to their choices. Developed using Adobe Aero, the book creates an immersive and fun way for children to engage with environmental topics.

The study uses a combination of …


From Unprepared To On Track: Closing The Kindergarten Readiness Gap By Using A Team-Based Approach To Implement A Multi-Tiered System Of Supports (Mtss) Framework With Fidelity, Erica Filipiak Jan 2025

From Unprepared To On Track: Closing The Kindergarten Readiness Gap By Using A Team-Based Approach To Implement A Multi-Tiered System Of Supports (Mtss) Framework With Fidelity, Erica Filipiak

Theses and Dissertations

We live in a world where preschool and even kindergarten are optional years in schooling, only perpetuating the problem of incoming kindergartener students systemically lacking foundational skills necessary to successfully begin their academic careers. Access to quality preschool is an equity problem that needs to be discussed and researched. Preparing a student to enter kindergarten with the appropriate foundational academic skills does not just set them up for kindergarten success, but also for success in future grade levels. Therefore, a co-design team focused a problem of practice at an elementary school to provide the kindergarten teacher with additional support by …


Boys Build, Girls Glam: An Examination Of Adult Language Use In Informal Steam Education Settings, Alexandra Horton Jan 2025

Boys Build, Girls Glam: An Examination Of Adult Language Use In Informal Steam Education Settings, Alexandra Horton

Theses and Dissertations

Research on STEAM education has primarily focused on formal education settings such as schools, with more research needed in informal or non-traditional education settings. As children frequently engage with informal and non-traditional education settings, it is important to understand how we can transmit information in these settings to bolster and further the learning process and increase engagement. STEAM fields have been plagued by racial and gender inequities that have led to these groups being marginalized and excluded (Blair et al., 2017; Eaton et al., 2020; Martin, 2018; Martin & Phillips, 2019; Miller et al., 2018; Newall et al., 2018, Sheffield …


The Experiences Of Black Male Dei Administrators At Historically White Institutions, Kwame R. Patterson Jr Jan 2025

The Experiences Of Black Male Dei Administrators At Historically White Institutions, Kwame R. Patterson Jr

Theses and Dissertations

This study examined the lived experiences of Black male Diversity, Equity, and Inclusion (DEI) administrators at Historically White Institutions (HWIs) in higher education. Drawing from Critical Race Theory (CRT) and the Campus Racial Climate Model, this research utilized a qualitative narrative inquiry to understand how Black male DEI administrators experience and navigate their roles, as well as the support systems they rely on to overcome barriers encountered at HWIs. I conducted interviews with 11 Black male DEI administrators from various HWIs. Three major themes emerged from the analysis: (1) Limited Legacy: What am I here for?, which highlights the unique …


Intersectionality And The Canon Of Romanticism, Serenah Minasian Jan 2025

Intersectionality And The Canon Of Romanticism, Serenah Minasian

Theses and Dissertations

This dissertation discusses the origins of the canon and the place it has in British Romanticism studies both past and present. This research begins unpacking what has already been done in this sector of study and takes it steps further by the use of Crenshaw’s “intersectionality” theory. The “Introduction” unpacks past scholarly work and its role in the present studies and how we must move beyond the past. “Chapter I” serves as a historical breakdown of the canon’s role and impact in both literary studies and Romanticism studies in specific. “Chapter II” provides an in depth analysis of two major …


Utilizing Information Technology And Hands-On Learning Practices To Improve Student Learning Outcomes In A High Failure Rate Introductory Programming Course, Todd Edward Thomas Jan 2025

Utilizing Information Technology And Hands-On Learning Practices To Improve Student Learning Outcomes In A High Failure Rate Introductory Programming Course, Todd Edward Thomas

Theses and Dissertations

The purpose of this study was to introduce and examine the impact that two interventions have on a high failure rate introductory programing course: a pedagogical approach of introducing Live Coding instruction technique to the in-person lecture portion, and a technological approach of introducing remote collaboration software (VS Code Liveshare) to the online lab portion. This study used convergent parallel mixed methods approach for both data collection and analysis; utilizing four data collection methods: 1) online survey questionnaires 2) in-depth interviews 3) in class observations and 4) quantifiable data collection (ie., student demographic, IT experience, GPA data). The Live Coding …


A Care-Focused Characterization Of Beginning Elementary Preservice Teachers’ Visions Of Mathematics Instruction, Alicia Marie Erwin Jan 2025

A Care-Focused Characterization Of Beginning Elementary Preservice Teachers’ Visions Of Mathematics Instruction, Alicia Marie Erwin

Theses and Dissertations

In this dissertation study, I sought to understand how elementary preservice teachers (EPTs) envisioned mathematics instruction at the beginning of their university program and what factors they identified as contributing to those visions. I conducted semi-structured interviews with 32 EPTs who had recently finished their first mathematics content course in their university program. I then connected theories of teacher care to characterize their visions of mathematical instruction.

Through my data analysis, I identified five themes that represented components of the EPTs’ beginning visions of mathematics instruction: Driver of the Math Task, Focus of the Math Task, Student Sharing, Classroom Environment, …


Breaching The Screen: A Digital Technofeminist Methodology For Virtual And Augmented Realities, Frank Macarthy Jan 2025

Breaching The Screen: A Digital Technofeminist Methodology For Virtual And Augmented Realities, Frank Macarthy

Theses and Dissertations

This dissertation provides a methodological framework that seeks to further scholarly and pedagogical inquiry at the intersections of feminist rhetorical studies, digital rhetoric, and cultural studies. More specifically, drawing upon theories of technofeminism (relationships among technology and feminism) and cyberfeminism (relationships among the internet and feminism), this dissertation proposes a digital technofeminist methodology to study the complex relationships between virtual, augmented, and mixed reality technologies, bodies, and rhetoric. This framework aims to help digital rhetoric scholar-teachers to critically investigate digital technologies that blur the distinction between virtuality, material bodies, and realities.

Building on digital rhetoric and technofeminist scholarship, this dissertation …


Exploring How Political Affiliations Influence Trust In Ai Applications, Md Imran Ahsan Jan 2025

Exploring How Political Affiliations Influence Trust In Ai Applications, Md Imran Ahsan

Theses and Dissertations

This paper examines the impact of partisanship on public trust in the utilization of Artificial Intelligence (AI) by private and public institutions. This study utilizes data from the “Artificial Intelligence: American Attitudes and Trends” survey (Zhang & Dafoe, 2019). Survey-weighted OLS regression models are employed to examine the variations in trust levels across different private and public institutions. This study hypothesizes that H1: Compared to Republicans, Democrats will report higher levels of confidence in public institutions to develop AI in the best interests of the public. H2: Compared to Democrats, Republicans will report higher levels of confidence in private institutions …


Immigration Identity And Policy Choices: Exploring How Immigration Status Shapes Public Attitudes Toward Immigration Policy, Ali Ahmad Jan 2025

Immigration Identity And Policy Choices: Exploring How Immigration Status Shapes Public Attitudes Toward Immigration Policy, Ali Ahmad

Theses and Dissertations

This study explores how immigration background influences public attitudes toward immigration policy. The study employs social identity theory and assimilation theory, which elucidate how group affiliation and generational proximity influence political attitudes. Drawing on these theories, the study hypothesizes that individuals with closer ancestor migration ties are more likely to show higher levels of support for favorable policies for immigrants compared to those who have more distant ancestor migration ties. Utilizing the 2020 Cooperative Election Study (CES) data, the analysis incorporates key demographic and ideological variables as control variables, such as education, gender, age, and family income. The study found …


High Throughput, Solid Sample Analysis With Cone-Based Mass Spectrometric Ionization Sources, Emily J. Wiggins Jan 2025

High Throughput, Solid Sample Analysis With Cone-Based Mass Spectrometric Ionization Sources, Emily J. Wiggins

Theses and Dissertations

The widespread presence of environmental and consumer-product contaminants (e.g. trace metals, opium alkaloids) has underscored the need for rapid, reliable, and high-throughput analytical techniques that are capable of handling complex solid samples. While traditional mass spectrometric (MS) methods tend to have high sensitivity and accuracy, they often require labor-intensive and time-consuming sample preparation steps that limit throughput and field applicability. This thesis investigates the use of 3D-Printed Cone Spray Ionization-Mass Spectrometry (3D-PCSI-MS) as an ambient ionization technique for the direct screening of contaminants from solid matrices, eliminating the need for traditional sample preparation and allowing for real-time analysis.

In …


"The Toughest Job You'll Ever Love": Identity Creation, Compartmentalization, And Belonging Among Queer Peace Corps Volunteers, Laura N. Keeran Jan 2025

"The Toughest Job You'll Ever Love": Identity Creation, Compartmentalization, And Belonging Among Queer Peace Corps Volunteers, Laura N. Keeran

Theses and Dissertations

The Peace Corps advertises that it accepts anyone, no matter their gender identity or sexual orientation; however, recruiters and staff ask volunteers to go back into the closet for their twenty-seven months of service due to the Peace Corps’ safety concerns about their volunteers being out in their host countries. Queer Peace Corps Volunteers (PCVs) answer the call to serve, accepting that it means they will need to keep their queer identities concealed for two years and three months. I conducted ethnographic interviews with ten people who have served or are currently serving in the Peace Corps and identify under …


Warriors Of Faith Vs Passive Men: Gender Binarism And Performance In Evangelical Christian Masculinity, Alexander Koch Jan 2025

Warriors Of Faith Vs Passive Men: Gender Binarism And Performance In Evangelical Christian Masculinity, Alexander Koch

Theses and Dissertations

My thesis examines communications and reflections of self (gendered and religious) in Midwest Evangelical Christian men. The focus was on how these groups perform their gender and religion with each other, and the tactics that were used to reinforce an acceptable notion of masculinity. Drawing upon literature on gender and masculinity studies, feminist philosophy, and hierarchical systems, my project aimed to analyze acceptable gender performance pushed by patriarchal gender norms and evangelical Christian groups. I incorporated multiple settings in my ethnographic study across the Midwest. Methods included semi-structured interviews and participant-observation of men’s conferences and Christian men’s groups, while reflecting …


More Than Players, More Than Coaches: Institutional Agents And Youth Development In Urban And Suburban Minority-Majority Neighborhoods, Rainah N. Folk Jan 2025

More Than Players, More Than Coaches: Institutional Agents And Youth Development In Urban And Suburban Minority-Majority Neighborhoods, Rainah N. Folk

Theses and Dissertations

Institutional agents play a crucial role in shaping youth development. While the institutional agent framework is well established in postsecondary research, less is known about its role during mid-adolescence. Using relational ethnography and responsive interviewing, this study compares an urban and a suburban high school in minority-majority neighborhoods in Cook County, Illinois, to explore how development is influenced through relationships between sport coaches and high school athletes. Athletes in both contexts face significant challenges tied to neighborhood conditions and socioeconomic status. In response, coaches form deeply caring and supportive relationships, though their roles diverge in ways shaped by their urban …


How Gps Communicate The Urgent Suspected Cancer Referral Pathway To Patients: A Qualitative Study Of Gp-Patient Consultations, Jessica Russell, Laura Boswell, Athena Ip, Jenny Harris, Hardeep Singh, Ashley Nd Meyer, Traber D Giardina, Afsana Bhuiya, Katriina L Whitaker, Georgia B Black Jan 2025

How Gps Communicate The Urgent Suspected Cancer Referral Pathway To Patients: A Qualitative Study Of Gp-Patient Consultations, Jessica Russell, Laura Boswell, Athena Ip, Jenny Harris, Hardeep Singh, Ashley Nd Meyer, Traber D Giardina, Afsana Bhuiya, Katriina L Whitaker, Georgia B Black

Faculty, Staff and Students Publications

Background: The UK National Institute for Health and Care (NICE) recommends that GPs inform patients referred onto the urgent suspected cancer (USC) pathway about what to expect from the service. However, there is a lack of evidence on patient experience and information needs at the point of referral. It is a challenge for GPs to communicate the reasons for referral and provide reassurance.

Aim: To examine how GPs communicate a potential cancer diagnosis and USC referral in practice.

Design & setting: This is a secondary analysis of a dataset of 23 audio-recorded GP-patient consultations, selected from a larger dataset of …


Comparative Analysis Of Imaging Modalities For Surveillance On Outcomes In Patients With Hepatocellular Carcinoma, Ahmed El Sabagh, Islam Mohamed, Mazen Elsheikh, Megha Bhongade, Eunji Jo, Susan G Hilsenbeck, Fasiha Kanwal, Prasun K Jalal Jan 2025

Comparative Analysis Of Imaging Modalities For Surveillance On Outcomes In Patients With Hepatocellular Carcinoma, Ahmed El Sabagh, Islam Mohamed, Mazen Elsheikh, Megha Bhongade, Eunji Jo, Susan G Hilsenbeck, Fasiha Kanwal, Prasun K Jalal

Faculty, Staff and Students Publications

Background and aims: The American Association for the Study of Liver Diseases recommends regular surveillance with ultrasonography (US) and alpha-feto protein every 6 months for patients at high risk of hepatocellular carcinoma (HCC). However, US is considered to be less effective than cross-sectional imaging modalities like computed tomography and magnetic resonance imaging for detecting early HCC. Limited data exist on the overall survival and receipt of curative treatment for patients undergoing surveillance with different imaging modalities.

Methods: We retrospectively reviewed patients (n = 1954) diagnosed with HCC between January 2011 and June 2021. Patients who developed HCC while on strict …


Association Between Hemoglobin A1c And Pediatric Asthma Control, Hewlett Pham, Rachelle Koehl, Han Woo, Tianshi David Wu, Anna Yue Qiu, Emily P Brigham, Nadia N Hansel, Meredith C Mccormack Jan 2025

Association Between Hemoglobin A1c And Pediatric Asthma Control, Hewlett Pham, Rachelle Koehl, Han Woo, Tianshi David Wu, Anna Yue Qiu, Emily P Brigham, Nadia N Hansel, Meredith C Mccormack

Faculty, Staff and Students Publications

Purpose: To examine the relationship between Hemoglobin A1c (HbA1c) and asthma outcomes in an urban cohort of children with asthma.

Methods: The AIRWEIGHS Study was a randomized controlled clinical trial of an air cleaner intervention testing the hypothesis that overweight/obese children would experience greater improvement in asthma control compared to normal weight children. The study enrolled 164 children with asthma from Baltimore, MD and assessed HbA1c levels and asthma outcomes during clinic visits at baseline and three months. HbA1c levels were analyzed as a continuous measure and categorized as either normal (< 5.7%) or consistent with pre-diabetes (≥5.7%). Asthma outcomes included standardized questionnaires, spirometry, and fractional exhaled nitric oxide (FeNO). Generalized Estimating Equation (GEE) regression models were used to analyze the association between the HbA1c and asthma outcomes.

Results: Participants included 164 children with an average …


External Validation Of A Novel Cancer-Associated Venous Thromboembolism Risk Assessment Score In A Safety-Net Hospital, Karlynn N Dulberger, Jennifer La, Ang Li, Saran Lotfollahzadeh, Asha Jose, Nhan V Do, Mary T Brophy, J Michael Gaziano, Katya Ravid, Vipul C Chitalia, Nathanael R Fillmore Jan 2025

External Validation Of A Novel Cancer-Associated Venous Thromboembolism Risk Assessment Score In A Safety-Net Hospital, Karlynn N Dulberger, Jennifer La, Ang Li, Saran Lotfollahzadeh, Asha Jose, Nhan V Do, Mary T Brophy, J Michael Gaziano, Katya Ravid, Vipul C Chitalia, Nathanael R Fillmore

Faculty, Staff and Students Publications

Background: Cancer-associated thrombosis (CAT) is a leading cause of death in patients diagnosed with cancer. However, pharmacologic thromboprophylaxis use in cancer patients must be carefully evaluated due to a 2-fold increased risk of experiencing a major bleeding event within this population. The electronic health record CAT (EHR-CAT) risk assessment model (RAM) was recently developed, and reports improved performance over the widely used Khorana score. Extensive RAM external validation is crucial to determine accuracy across diverse patient populations prior to clinical utilization.

Objectives: To externally validate EHR-CAT using data from 2103 patients with cancer at the Boston Medical Center (BMC), New …


Evaluation Of Real-World Evidence To Assess Effectiveness Outcomes Of Janus Kinase Inhibitors For Rheumatoid Arthritis: A Systematic Review Of Us Studies, Chandler Gandy, Shadi Bazzazzadehgan, Sebastian Bruera, Yinan Huang Jan 2025

Evaluation Of Real-World Evidence To Assess Effectiveness Outcomes Of Janus Kinase Inhibitors For Rheumatoid Arthritis: A Systematic Review Of Us Studies, Chandler Gandy, Shadi Bazzazzadehgan, Sebastian Bruera, Yinan Huang

Faculty, Staff and Students Publications

Objective: This review summarized the real-world effectiveness outcomes of Janus kinase inhibitors (JAKi) for rheumatoid arthritis (RA) based on observational studies.

Methods: A systematic review followed PRISMA guidelines, with searches conducted in PubMed, Embase, and CINAHL from each database's inception to June 2, 2023. Studies were included if they evaluated real-world effectiveness outcomes of JAKi for US RA patients. Search terms included "RA", "JAKi", and "real-world". All citations were imported into COVIDENCE platform. Two reviewers independently performed title/abstract screening and full-text eligibility. For each article, study characteristics and effectiveness measures focusing on treatment pattern, clinical response, and patient-reported outcomes (PROs) …


Baseline Predictors For 28-Day Covid-19 Severity And Mortality Among Hospitalized Patients: Results From The Impacc Study, Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M Becker, Alison D Augustine, Al Ozonoff, Leying Guan, Steven H Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R Langelier, Holden Maecker, Seunghee Kim, Ruth R Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E Bosinger, Ofer Levy, Hanno Steen, Lindsey B Rosen, Lindsey R Baden, Esther Melamed, Lauren I R Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Joanna Schaenman, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S Calfee, David J Erle, Impacc Network, Lucy F Robinson, Charles B Cairns, Elias K Haddad, Mary Ann Comunale Jan 2025

Baseline Predictors For 28-Day Covid-19 Severity And Mortality Among Hospitalized Patients: Results From The Impacc Study, Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M Becker, Alison D Augustine, Al Ozonoff, Leying Guan, Steven H Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R Langelier, Holden Maecker, Seunghee Kim, Ruth R Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E Bosinger, Ofer Levy, Hanno Steen, Lindsey B Rosen, Lindsey R Baden, Esther Melamed, Lauren I R Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Joanna Schaenman, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S Calfee, David J Erle, Impacc Network, Lucy F Robinson, Charles B Cairns, Elias K Haddad, Mary Ann Comunale

Faculty, Staff and Students Publications

Introduction: The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demographic, blood cytometry, serum receptor-binding domain (RBD) antibody titers, metabolomics, targeted proteomics, nasal metagenomics, Olink, nasal viral load, autoantibody, SARS-CoV-2 antibody titers, and nasal and peripheral blood mononuclear cell (PBMC) transcriptomics data from patients hospitalized with COVID-19. The aim of this study is to select baseline biomarkers and build predictive models for 28-day in-hospital COVID-19 severity and mortality with most predictive variables while prioritizing routinely collected variables.

Methods: We analyzed 1102 …


Utility Of Microbial Cell-Free Dna Sequencing In The Diagnosis Of Mycobacterial Infections In A Quaternary Care Center, Fernando H Centeno, Todd Lasco, Ahmed M Hamdi, Mayar Al Mohajer Jan 2025

Utility Of Microbial Cell-Free Dna Sequencing In The Diagnosis Of Mycobacterial Infections In A Quaternary Care Center, Fernando H Centeno, Todd Lasco, Ahmed M Hamdi, Mayar Al Mohajer

Faculty, Staff and Students Publications

We examine the performance of microbial cell-free DNA (mcfDNA) next-generation sequencing (NGS) testing on patients admitted to a quaternary care hospital in Houston, Texas. The test was 75.0% sensitive and 97.8% specific for all mycobacterial infections. mcfDNA NGS results led to adjustments in antimicrobial therapy for seven of nine patients with positive results.