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2025

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Adaptive Fusion Neural Networks For Sparse-Angle X-Ray 3d Reconstruction, Shaoyong Hong, Bo Yang, Yan Chen, Hao Quan, Shan Liu, Minyi Tang, Jiawei Tian Jan 2025

Adaptive Fusion Neural Networks For Sparse-Angle X-Ray 3d Reconstruction, Shaoyong Hong, Bo Yang, Yan Chen, Hao Quan, Shan Liu, Minyi Tang, Jiawei Tian

Electrical & Computer Engineering Faculty Publications

3D medical image reconstruction has significantly enhanced diagnostic accuracy, yet the reliance on densely sampled projection data remains a major limitation in clinical practice. Sparse-angle X-ray imaging, though safer and faster, poses challenges for accurate volumetric reconstruction due to limited spatial information. This study proposes a 3D reconstruction neural network based on adaptive weight fusion (AdapFusionNet) to achieve high-quality 3D medical image reconstruction from sparse-angle X-ray images. To address the issue of spatial inconsistency in multi-angle image reconstruction, an innovative adaptive fusion module was designed to score initial reconstruction results during the inference stage and perform weighted fusion, thereby improving …


Analyzing Visual Attention In Virtual Crime Scene Investigations Using Eye-Tracking And Vr: Insights For Cognitive Modeling, Wen-Chao Yang, Chih-Hung Shih, Jiajun Jiang, Sergio Pallas Enguita, Chung-Hao Chen Jan 2025

Analyzing Visual Attention In Virtual Crime Scene Investigations Using Eye-Tracking And Vr: Insights For Cognitive Modeling, Wen-Chao Yang, Chih-Hung Shih, Jiajun Jiang, Sergio Pallas Enguita, Chung-Hao Chen

Electrical & Computer Engineering Faculty Publications

Understanding human perceptual strategies in high-stakes environments, such as crime scene investigations, is essential for developing cognitive models that reflect expert decision-making. This study presents an immersive experimental framework that utilizes virtual reality (VR) and eye-tracking technologies to capture and analyze visual attention during simulated forensic tasks. A 360° panoramic crime scene, constructed using the Nikon KeyMission 360 camera, was integrated into a VR system with HTC Vive and Tobii Pro eye-tracking components. A total of 46 undergraduate students aged 19 to 24–23, from the National University of Singapore in Singapore and 23 from the Central Police University in Taiwan—participated …


Potential Of Lidar And Hyperspectral Sensing For Overcoming Challenges In Current Maritime Ballast Tank Corrosion Inspection, Sergio Pallas Enguita, Jiajun Jiang, Chung-Hao Chen, Samuel Kovacic, Richard Lebel Jan 2025

Potential Of Lidar And Hyperspectral Sensing For Overcoming Challenges In Current Maritime Ballast Tank Corrosion Inspection, Sergio Pallas Enguita, Jiajun Jiang, Chung-Hao Chen, Samuel Kovacic, Richard Lebel

Electrical & Computer Engineering Faculty Publications

Corrosion in maritime ballast tanks is a major driver of maintenance costs and operational risks for maritime assets. Inspections are hampered by complex geometries, hazardous conditions, and the limitations of conventional methods, particularly visual assessment, which struggles with subjectivity, accessibility, and early detection, especially under coatings. This paper critically examines these challenges and explores the potential of Light Detection and Ranging (LiDAR) and Hyperspectral Imaging (HSI) to form the basis of improved inspection approaches. We discuss LiDAR’s utility for accurate 3D mapping and providing a spatial framework and HSI’s potential for objective material identification and surface characterization based on spectral …


A Method For Ultrasound Servo Tracking For Puncture Needle, Shitong Ye, Bo Yang, Hao Quan, Shan Liu, Minyu Tang, Jiawei Tian Jan 2025

A Method For Ultrasound Servo Tracking For Puncture Needle, Shitong Ye, Bo Yang, Hao Quan, Shan Liu, Minyu Tang, Jiawei Tian

Electrical & Computer Engineering Faculty Publications

Computer-aided surgical navigation technology helps and guides doctors to complete the operation smoothly, which simulates the whole surgical environment with computer technology, and then visualizes the whole operation link in three dimensions. At present, common image-guided surgical techniques such as computed tomography (CT) and X-ray imaging (X-ray) will cause radiation damage to the human body during the imaging process. To address this, we propose a novel Extended Kalman filter-based model that tracks the puncture needle-point using an ultrasound probe. To address the limitations of Kalman filtering methods based on position and velocity, our method of Kalman filtering uses the position …


A Customized Large Single-Piece Bifrontal Implant For Post-Craniectomy Defect Reconstruction: A Case Study, Omid Ghaderzadeh, Ehsan Amirbeyk, Seyed Roholah Ghodsi, Zahra Namazi, Lobat Tayebi Jan 2025

A Customized Large Single-Piece Bifrontal Implant For Post-Craniectomy Defect Reconstruction: A Case Study, Omid Ghaderzadeh, Ehsan Amirbeyk, Seyed Roholah Ghodsi, Zahra Namazi, Lobat Tayebi

Electrical & Computer Engineering Faculty Publications

Background: Large bifrontal defects pose unique reconstruction challenges due to their complex curvature and mechanical requirements. This case demonstrated how computer-aided design/manufacturing (CAD/CAM) enabled precise single-piece polymethyl methacrylate (PMMA) implant fabrication, thereby overcoming traditional limitations. Case presentation: A 25-year-old male who had undergone bifrontal decompressive craniectomy suffered a severe traumatic brain injury. The autologous bone flap had been temporarily stored in a subcutaneous fat area of the abdomen for 3 months to preserve its viability. A secondary cranioplasty was then performed using titanium miniplates and self-tapping screws for final fixation. After 2 years, the patient developed empyema and a brain …


Leveraging Large Language Models To Create Learner Personas For Training Design, N. Lovett, M. Yang, K. Herman, B. Li, M. Sosonkina, W. Purwanto, P. Jiang, M. H. Wu Jan 2025

Leveraging Large Language Models To Create Learner Personas For Training Design, N. Lovett, M. Yang, K. Herman, B. Li, M. Sosonkina, W. Purwanto, P. Jiang, M. H. Wu

Electrical & Computer Engineering Faculty Publications

This case examines the innovative use of Large Language Models (LLMs) to generate learner personas for developing learner-centered cybersecurity training materials when direct access to initial learner data is not available. The team developed a nine-stage iterative process for creating and refining AI-generated personas to address this constraint, integrating ethical review, stakeholder feedback, and action research principles. The process expanded upon Kouprie and Visser’s (2009) empathic design framework to ensure cultural responsiveness and mitigate potential biases in LLM outputs. Through multiple refinement cycles, initial generic personas evolved into detailed, context-rich archetypes which informed the development of effective and context-responsive training …


A Proximal Policy Optimization-Based Controller For Enhanced Power Sharing In Microgrids, Seyedmohammad Hasheminasab, Armin Lotfy, Mohamad Alzayed, Hicham Chaoui Jan 2025

A Proximal Policy Optimization-Based Controller For Enhanced Power Sharing In Microgrids, Seyedmohammad Hasheminasab, Armin Lotfy, Mohamad Alzayed, Hicham Chaoui

Electrical & Computer Engineering Faculty Publications

This paper introduces a Proximal Policy Optimization (PPO)-based virtual impedance (VI) controller to enhance both power sharing and system response under disturbances in inverter-interfaced microgrids. Traditional droop control methods often face challenges due to variations in feeder impedance, which degrade performance. The proposed controller continuously updates its policy based on changes in the operating environment. The control problem is modeled as a Markov Decision Process (MDP), in which the state and action spaces are explicitly defined, and a carefully designed reward function, satisfying system criteria and constraints, guides the learning process toward achieving the desired transient and steady-state performance. By …


Development Of 2d Microfluidics Surface With Low-Frequency Electric Fields For Cell Separation Applications, Madushan Wickramasinghe, Dharmakeerthi Nawarathna Jan 2025

Development Of 2d Microfluidics Surface With Low-Frequency Electric Fields For Cell Separation Applications, Madushan Wickramasinghe, Dharmakeerthi Nawarathna

Electrical & Computer Engineering Faculty Publications

Cell separation techniques are widely used in many biomedical and clinical applications for the development of screening, diagnosis and therapeutic tests. Current 3D microfluidics-based cell separation methods have limited applications in part due to low throughput and technical complexity. To address these critical needs, we have developed a 2D microfluidics surface which is the miniaturized version of a 3D microfluids cell separation device. Using low-frequency electric fields (1–10 Vpp and 1 kHz–20 MHz), we have first studied dielectrophoresis, AC electro-osmosis and capillary flow within a sessile drop, and finally utilized the results to develop the 2D cell separation surface. Our …


A Novel Intelligent Thermal Feedback Framework For Electric Motor Protection In Embedded Robotic Systems, Mohamed Shili, Salah Hammedi, Hicham Chaoui, Khaled Nouri Jan 2025

A Novel Intelligent Thermal Feedback Framework For Electric Motor Protection In Embedded Robotic Systems, Mohamed Shili, Salah Hammedi, Hicham Chaoui, Khaled Nouri

Electrical & Computer Engineering Faculty Publications

As robotic systems advance in autonomy and sophistication while being used in uncertain environments, the challenge of building reliable and robust electric motors that are embedded into robotic systems has never been a more important engineering problem. Thermal distress caused by extended operation or excessive loading can negatively affect a motor’s performance and efficiency and lead to catastrophic hardware failure. This paper proposes a novel intelligent control framework that includes real-time thermal feedback for hybrid electric motors that are embedded into robotic systems. The framework relies on adaptive control techniques and lightweight machine learning techniques to estimate internal motor temperatures …


Energy-Aware Sensor Fusion Architecture For Autonomous Channel Robot Navigation In Constrained Environments, Mohamed Shili, Hicham Chaoui, Khaled Nouri Jan 2025

Energy-Aware Sensor Fusion Architecture For Autonomous Channel Robot Navigation In Constrained Environments, Mohamed Shili, Hicham Chaoui, Khaled Nouri

Electrical & Computer Engineering Faculty Publications

Navigating autonomous robots in confined channels is inherently challenging due to limited space, dynamic obstacles, and energy constraints. Existing sensor fusion strategies often consume excessive power because all sensors remain active regardless of environmental conditions. This paper presents an energy-aware adaptive sensor fusion framework for channel robots that deploys RGB cameras, laser range finders, and IMU sensors according to environmental complexity. Sensor data are fused using an adaptive Extended Kalman Filter (EKF), which selectively integrates multi-sensor information to maintain high navigation accuracy while minimizing energy consumption. An energy management module dynamically adjusts sensor activation and computational load, enabling significant reductions …


Streamer Discharge Modeling For Plasma-Assisted Combustion, Stuart Reyes, Shirshak Kumar Dhali Jan 2025

Streamer Discharge Modeling For Plasma-Assisted Combustion, Stuart Reyes, Shirshak Kumar Dhali

Electrical & Computer Engineering Faculty Publications

Some of the popular and successful atmospheric pressure fuel/air plasma-assisted combustion methods use repetitive ns pulsed discharges and dielectric-barrier discharges. The transient phase in such discharges is dominated by transport under strong space charge from ionization fronts, which is best characterized by the streamer model. The role of the nonthermal plasma in such discharges is to produce radicals, which accelerates the chemical conversion reaction leading to temperature rise and ignition. Therefore, the characterization of the streamer and its energy partitioning is essential to develop a predictive model. We examine the important characteristics of streamers that influence combustion and develop some …


A Worker's Struggle, Sakan Binte Imran, Shadman Mahmood Khan Pathan Jan 2025

A Worker's Struggle, Sakan Binte Imran, Shadman Mahmood Khan Pathan

Electrical & Computer Engineering Faculty Publications

[Introduction] The casualty department at Sir Salimullah Medical College Mitford Hospital was crowded, as it always was. The air smelled of antiseptics, and hurried footsteps echoed through the narrow corridors. It was another day of internship, and I had just finished checking on a patient when a nurse called me over.

“There’s a new case in Trauma. Factory worker. Severe hand injury.”

I hurried over and found a man sitting on the examination table. His face was pale, and his forehead was glistening with sweat. His right hand was wrapped in a blood-soaked cloth. His left hand trembled as he …


Enhancing Cyber Situational Awareness Through Dynamic Adaptive Symbology: The Dass Framework, Nicholas Macrino, Sergio Pallas Enguita, Chung-Hao Chen Jan 2025

Enhancing Cyber Situational Awareness Through Dynamic Adaptive Symbology: The Dass Framework, Nicholas Macrino, Sergio Pallas Enguita, Chung-Hao Chen

Electrical & Computer Engineering Faculty Publications

The static nature of traditional military symbology, such as MIL-STD-2525D, hinders effective real-time threat detection and response in modern cybersecurity operations. This research introduces the Dynamic Adaptive Symbol System (DASS), a novel framework enhancing cyber situational awareness in military and enterprise environments. The DASS addresses static symbology limitations by employing a modular Python 3.10 architecture that uses machine learning-driven threat detection to dynamically adapt symbol visualization based on threat severity and context. Empirical testing assessed the DASS against a MIL-STD-2525D baseline using active cybersecurity professionals. Results show that the DASS significantly improves threat identification rates by 30% and reduces response …


Ai-Based Steganography Method To Enhance The Information Security Of Hidden Messages In Digital Images, Nhi Do Ngoc Huynh, Jiajun Jiang, Chung-Hao Chen, Wen-Chao Yang Jan 2025

Ai-Based Steganography Method To Enhance The Information Security Of Hidden Messages In Digital Images, Nhi Do Ngoc Huynh, Jiajun Jiang, Chung-Hao Chen, Wen-Chao Yang

Electrical & Computer Engineering Faculty Publications

With the increasing sophistication of Artificial Intelligence (AI), traditional digital steganography methods face a growing risk of being detected and compromised. Adversarial attacks, in particular, pose a significant threat to the security and robustness of hidden information. To address these challenges, this paper proposes a novel AI-based steganography framework designed to enhance the security of concealed messages within digital images. Our approach introduces a multi-stage embedding process that utilizes a sequence of encoder models, including a base encoder, a residual encoder, and a dense encoder, to create a more complex and secure hiding environment. To further improve robustness, we integrate …


Automating The Amino Acid Identification In Elliptical Dichroism Spectrometer With Machine Learning, Ridhanya Sree Balamurugan, Yusuf Asad, Tommy Gao, Dharmakeerthi Nawarathna, Umamaheswara Rao Tida, Dali Sun Jan 2025

Automating The Amino Acid Identification In Elliptical Dichroism Spectrometer With Machine Learning, Ridhanya Sree Balamurugan, Yusuf Asad, Tommy Gao, Dharmakeerthi Nawarathna, Umamaheswara Rao Tida, Dali Sun

Electrical & Computer Engineering Faculty Publications

Amino acid identification is crucial across various scientific disciplines, including biochemistry, pharmaceutical research, and medical diagnostics. However, traditional methods such as mass spectrometry require extensive sample preparation and are time-consuming, complex and costly. Therefore, this study presents a pioneering Machine Learning (ML) approach for automatic amino acid identification by utilizing the unique absorption profiles from an Elliptical Dichroism (ED) spectrometer. Advanced data preprocessing techniques and ML algorithms to learn patterns from the absorption profiles that distinguish different amino acids were investigated to prove the feasibility of this approach. The results show that ML can potentially revolutionize the amino acid analysis …


Optimizing Ai Language Models: A Study Of Chatgpt-4 Vs. Chatgpt-4o, Md Nurul Absar Siddiky, Muhammad Enayetur Rahman, Md Fayaz Bin Hossen, Muhammad Rezaur Rahman, Md. Shahadat Jaman Jan 2025

Optimizing Ai Language Models: A Study Of Chatgpt-4 Vs. Chatgpt-4o, Md Nurul Absar Siddiky, Muhammad Enayetur Rahman, Md Fayaz Bin Hossen, Muhammad Rezaur Rahman, Md. Shahadat Jaman

Electrical & Computer Engineering Faculty Publications

This paper presents a comparative analysis of OpenAI's GPT-4 and its optimized variant, GPT-4o, focusing on their architectural differences, performance, and real-world applications. GPT-4, built upon the Transformer architecture, has set new standards in natural language processing (NLP) with its capacity to generate coherent and contextually relevant text across a wide range of tasks. However, its computational demands, requiring substantial hardware resources, make it less accessible for smaller organizations and real-time applications. In contrast, GPT-4o addresses these challenges by incorporating optimizations such as model compression, parameter pruning, and memory-efficient computation, allowing it to deliver similar performance with significantly lower computational …


T3-Ciders: Fostering A Community Of Practice In Ci-And Data Enabled Cybersecurity Research Through A Train-The-Trainer Program, Wirawan Purwanto, Mohan Yang, Peng Jiang, Masha Sosonkina Jan 2025

T3-Ciders: Fostering A Community Of Practice In Ci-And Data Enabled Cybersecurity Research Through A Train-The-Trainer Program, Wirawan Purwanto, Mohan Yang, Peng Jiang, Masha Sosonkina

Electrical & Computer Engineering Faculty Publications

We present a training program named T³-CIDERS, the Train- The-Trainer approach to fostering cyberinfrastructure (CI)- and Data-Enabled Research in CyberSecurity. T³-CIDERS is a train-the-trainer program for advanced cyberinfrastructure (CI) skills that is designed to be synergistic with research, teaching, and learning activities in cybersecurity and cyber-related disciplines. The participants, termed 'future trainers' (FTs), are trained in effective instructional design and CI hands-on materials from DeapSECURE, developed in a previous CyberTraining program. T³-CIDERS aims to enhance cybersecurity research and education through broader adoption of advanced CI techniques such as artificial intelligence, big data, parallel programming, and platforms like high-performance computing (HPC) …


Separating The Impacts Of A Corrosion Inhibitor From Copper Corrosion Products On Antibiotic Resistance In Drinking Water, Veronika Folvarska, Maya Adelgren, Emily Lou Lamartina, Ryan J. Newton, Yin Wang, Patrick J. Mcnamara Jan 2025

Separating The Impacts Of A Corrosion Inhibitor From Copper Corrosion Products On Antibiotic Resistance In Drinking Water, Veronika Folvarska, Maya Adelgren, Emily Lou Lamartina, Ryan J. Newton, Yin Wang, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Antibiotic resistance is a growing threat to public health, and environmental factors, including metals in drinking water distribution systems, are increasingly recognized as contributors to the spread of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). Zinc orthophosphate, a common corrosion inhibitor, and copper corrosion products (CuO and Cu2O) are frequently present in drinking water systems. While each has been shown to increase ARB and ARGs individually, their combined effects remain unknown. The objective of this study was to evaluate the combined impact of copper corrosion products and the corrosion inhibitor zinc orthophosphate on antibiotic resistance. Two …


The Forms Of Representation: How To Be A Kantian Realist, Willem A. Devries Jan 2025

The Forms Of Representation: How To Be A Kantian Realist, Willem A. Devries

Faculty Publications

Sellars argued that Kant did not make certain distinctions concerning space and time, and because of this adopted his transcendental idealism. Once these distinctions are made, the path to realism remains open. Sellars' argument is not entirely clear. This essay attempts to clarify the argument, showing why Sellars believed he could remain a scientific realist while also adopting a Kantian style epistemology.


Growing Organizational Marketing, Publicity, And Outreach Strategies With Intention, Elizabeth R. Fowler, Wendy G. Pothier, Donald Dow Jan 2025

Growing Organizational Marketing, Publicity, And Outreach Strategies With Intention, Elizabeth R. Fowler, Wendy G. Pothier, Donald Dow

Faculty Publications

Marketing is a necessary function of academic libraries but is frequently deprioritized in library job descriptions and organizational structures. This article serves as a case study of how one library worked to formalize marketing efforts by moving from ad hoc committee-based work to structured positions guided by an organizational marketing plan. Sharing examples over time to show the impact of marketing efforts, the authors detail the process of creating an outline for a marketing plan, as well as new initiatives that developed through the process.


Chatbot Assessment: Best Practices For Artificial Intelligence In The Library, Michelle Ehrenpreis, John P. Delooper Jan 2025

Chatbot Assessment: Best Practices For Artificial Intelligence In The Library, Michelle Ehrenpreis, John P. Delooper

Publications and Research

In November 2019, the Leonard Lief Library implemented Ivy.ai, a proprietary chatbot on its website. This implementation was the first academic library installation of a vendor-supplied chatbot to be discussed in the professional literature. This chatbot functioned as a new tool that assisted users seeking information from the library website. User questions provided insight to the authors about the kinds of topics students searched for via the library website. In April 2023, the chatbot’s vendor began using OpenAI’s ChatGPT Application Programming Interface (API) to improve the chatbot’s functionality. This change, from a rules-based chatbot system to a transformer model, enhanced …


Multiplicity, Belonging, And Free Speech In Us Higher Education: Thriving Through Current Crises, Naomi Zack Jan 2025

Multiplicity, Belonging, And Free Speech In Us Higher Education: Thriving Through Current Crises, Naomi Zack

Publications and Research

New realities in U.S. higher education present a multifaceted crisis for students, faculty, administrators, and society at large. This book provides incisive diagnoses of pressing problems and prescriptions to reinstate and support U.S. higher education as an intellectually and ethically valuable institution.


Civic Participation And Meaning In Life: Similarities And Differences Across Diverse Youth, Yue Ni, G. John Geldhof, Richard A. Settersten, Shauna L. Tominey Jan 2025

Civic Participation And Meaning In Life: Similarities And Differences Across Diverse Youth, Yue Ni, G. John Geldhof, Richard A. Settersten, Shauna L. Tominey

Psychology Faculty Publications and Presentations

Civic engagement is an important component of youth thriving, but prior research—focused primarily on political engagement—has found a “civic engagement gap” between youth with marginalized identities and those with privileged social identities. Research is needed to understand youth involvement in other civic activities, patterns of disparities, and any implications of these differences for youth well-being. In this study, we examined differences in community service activities, political activities, and expressive activities and their relationships with meaning in life 2 years later across 11 groups of 1,088 adolescents defined by intersections of race/ethnicity, socioeconomic status, and nativity. Findings reveal great diversity in …


A Case Of Navigating Autism And Atypical Rashes In Dermatology Practice., Benjamin S Kahn, Kathleen Ward, Nedyalko Ivanov, Marcus Goodman Jan 2025

A Case Of Navigating Autism And Atypical Rashes In Dermatology Practice., Benjamin S Kahn, Kathleen Ward, Nedyalko Ivanov, Marcus Goodman

PCOM Scholarly Works

A 4-year-old nonverbal autistic female presented to the clinic with a 3-month history of a persistent, inflamed papular rash, which was violaceous to skin-toned, verrucous, and dome-shaped with crateriform ulcerations on an erythematous base localized in the perianal region. A dermatologic condition with these characteristics, location, and demographic warrants a thorough workup, physical exam, and broad differential diagnosis. The clinical appearance of these lesions can mimic many cutaneous conditions in this age group and requires careful attention for potential signs of abuse. As demonstrated in our case, with a comprehensive patient history, a biopsy, and a culture of the lesions, …


Increased Myo/Nog Cell Presence And Phagocytic Activity In Retinal Degeneration: Insights From A Mouse Model, Diana Crowley, Samantha Murad, Courtney Helm, Rachel Souza, Sarah Coughlan, Scott Serpico, Eric Sugarman, Kyle Marguiles, Brian Heist, Kathryn D. Mitchell, Christopher K. Sutera, Mark Martin, Carlos Font, Mary Woodruff, E-Jine Tsai, Rushil Brahmbhatt, Paul Lecker, Grzegorz Gorski, John Benalcazar, Serena Young, Abey Martin, Lindsay Gugerty, Jacquelyn Gerhart, Mindy George-Weinstein, Arturo Bravo Nuevo Jan 2025

Increased Myo/Nog Cell Presence And Phagocytic Activity In Retinal Degeneration: Insights From A Mouse Model, Diana Crowley, Samantha Murad, Courtney Helm, Rachel Souza, Sarah Coughlan, Scott Serpico, Eric Sugarman, Kyle Marguiles, Brian Heist, Kathryn D. Mitchell, Christopher K. Sutera, Mark Martin, Carlos Font, Mary Woodruff, E-Jine Tsai, Rushil Brahmbhatt, Paul Lecker, Grzegorz Gorski, John Benalcazar, Serena Young, Abey Martin, Lindsay Gugerty, Jacquelyn Gerhart, Mindy George-Weinstein, Arturo Bravo Nuevo

PCOM Scholarly Works

Myo/Nog cells play a pivotal role in ocular development and demonstrate a rapid response to stress and injury. This study investigates their behavior and distribution in a murine model of retinitis pigmentosa, specifically in C3H/HeJ mice, which exhibit photoreceptor degeneration due to a homozygous mutation in the Pde6brd1 gene. Retinal samples from C3H/HeJ and C57BL/6J mice were analyzed at postnatal weeks 2.5 to 6 using hematoxylin and eosin staining, immunofluorescence for brain-specific angiogenesis inhibitor 1 (BAI1) expressed in Myo/Nog cells, and TUNEL labeling for apoptotic cell detection. The results demonstrated a progressive thinning of the outer nuclear layer (ONL) in …


Infections With Chlamydia Pneumoniae And Sars-Cov-2 And Alzheimer's Disease Pathogenesis, Alexa Romanella, Maegan Mccall, Rachel Corwin, Alaha Abdul Faruq, Emily Lingo, Sanya Bhambhani, Christine J. Hammond, Brian J. Balin Jan 2025

Infections With Chlamydia Pneumoniae And Sars-Cov-2 And Alzheimer's Disease Pathogenesis, Alexa Romanella, Maegan Mccall, Rachel Corwin, Alaha Abdul Faruq, Emily Lingo, Sanya Bhambhani, Christine J. Hammond, Brian J. Balin

PCOM Scholarly Works

INTRODUCTION: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the world, but our understanding of causation is still lacking. A current evidence-based hypothesis proposes that certain infectious agents initiate the neurodegeneration consistent with AD. Two infectious agents correlated to AD pathogenesis are Chlamydia pneumoniae (Cpn), a respiratory obligate intracellular bacterium, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus responsible for the COVID-19 pandemic. Both organisms may predispose susceptible populations to disease manifestations, such as AD.

METHODS: This review focused on peer-reviewed original research and review articles evaluating the potential association of Cpn and SARS-CoV-2 with AD. …


Rebuttal: Reduced Oxidative Capacity Of Skeletal Muscle Is Not An Inevitable Consequence Of Adult Ageing, Ian R. Lanza, Christopher W. Sundberg, Jane A. Kent Jan 2025

Rebuttal: Reduced Oxidative Capacity Of Skeletal Muscle Is Not An Inevitable Consequence Of Adult Ageing, Ian R. Lanza, Christopher W. Sundberg, Jane A. Kent

Physical Therapy Faculty Research and Publications

We thank Drs Marcinek and Ferrucci for their perspective on the inevitability of age-related declines in skeletal muscle oxidative capacity (Marcinek & Ferrucci, 2025). We agree that mitochondria have numerous roles in the cell beyond provision of chemical energy, many of which may be altered by ageing, but our focus in this debate is entirely on its role in energy production.


Perspectives Of Midwives And Nurse Practitioners In Kentucky On Exercise Counseling During Pregnancy: A Qualitative Study, Madhawa Perera, Taniya S. Nagpal, Maire M. Blankenship, Dano Tolusso, Jordyn Cox, Dilini Prashadika, Mark Schafer, Rachel A. Tinius Jan 2025

Perspectives Of Midwives And Nurse Practitioners In Kentucky On Exercise Counseling During Pregnancy: A Qualitative Study, Madhawa Perera, Taniya S. Nagpal, Maire M. Blankenship, Dano Tolusso, Jordyn Cox, Dilini Prashadika, Mark Schafer, Rachel A. Tinius

Physical Therapy Faculty Research and Publications

Introduction

Healthcare professionals are in an optimal position to deliver exercise information to pregnant women, yet previous research suggests this seldom happens. Midwives and nurse practitioners, who may have more time with pregnant women, are particularly well suited for this role.

Objectives

This qualitative study examined the exercise advice and counseling provided by midwives and nurse practitioners in Kentucky, focusing on the barriers they face.

Methods

Twenty-one midwives and nurse practitioners were recruited until the sample size reached saturation. A survey with open-ended questions was distributed to potential participants in regional hospitals, universities, and professional associations. The framework method was …


Age-Related Differences In Eye Movements And The Association With Archimedes Spiral Tracing Performance In Young And Older Adults, Brittany Heintz Walters, Wendy E. Huddleston, Kristian M. O'Connor, Jinsung Wang, Marie K. Hoeger Bement, Kevin G. Keenan Jan 2025

Age-Related Differences In Eye Movements And The Association With Archimedes Spiral Tracing Performance In Young And Older Adults, Brittany Heintz Walters, Wendy E. Huddleston, Kristian M. O'Connor, Jinsung Wang, Marie K. Hoeger Bement, Kevin G. Keenan

Physical Therapy Faculty Research and Publications

Age-related hand motor impairments may critically depend on visual information though few studies have examined eye movements during tasks of hand function in older adults. The purpose of this study was to assess eye movements and their association with performance while tracing on a touchscreen in young and older adults. Eye movements of 21 young (age 20–38 years; 12 females, 9 males) and 20 older (65–85 years; 10 females, 10 males) adults were recorded while performing an Archimedes spiral tracing task, a common clinical assessment sensitive to age-associated impairments in hand function. Participants traced an Archimedes spiral template on a …


Reduced Oxidative Capacity Of Skeletal Muscle Is Not An Inevitable Consequence Of Adult Ageing, Ian R. Lanza, Christopher W. Sundberg, Jane A. Kent Jan 2025

Reduced Oxidative Capacity Of Skeletal Muscle Is Not An Inevitable Consequence Of Adult Ageing, Ian R. Lanza, Christopher W. Sundberg, Jane A. Kent

Physical Therapy Faculty Research and Publications

Skeletal muscles support posture and locomotion, thermoregulation, cardiorespiratory function, metabolic health and other important aspects of life. Muscles generate chemical energy by synthesizing ATP through the creatine kinase reaction, glycolysis, and oxidative phosphorylation (oxphos), the latter of which produces the majority of ATP in the cell. Oxidative phosphorylation occurs in the mitochondrion, which is structured as a reticulum located near the ATPases responsible for powering the cross-bridge cycle, calcium pumps and membrane homeostasis (Glancy et al., 2015). Energy production in mitochondria is accomplished by coupling the oxidation of reducing equivalents (NADH, FADH2) in the electron transport chain (ETC) …