Digital Commons Network^™

Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng

Turkish Journal of Biology

Background/aim: Fibroblast Growth Factor Receptor (FGFR) gene fusions are recognized as pivotal oncogenic drivers, contributing to cancer initiation and progression across diverse malignancies. These fusions often represent significant therapeutic targets, particularly in challenging malignancies like cholangiocarcinoma. This study aimed to characterize the novel FGFR2::SHTN1 fusion, identify it as a de novo chimeric protein, and elucidate its precise oncogenic mechanism. Materials and methods: FGFR2::SHTN1 fusions were identified via cancer genomics databases and modeled using AlphaFold and HADDOCK. SHTN1 variants were expressed in Neuro-2a cells for coimmunoprecipitation, purification, and native polyacrylamide gel electrophoresis to assess oligomerization. Structural modeling included membrane embedding with …

Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak

Turkish Journal of Biology

Background/aim: This study aimed to investigate the phenotypic resistance and distribution of efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. isolated from dairy and meat samples. Antimicrobial resistance in foodborne bacteria increases with antibiotic exposure and biocides, particularly through efflux mechanisms. Thus, monitoring potential genetic reservoirs in the food chain is very important. Materials and methods: A total of 132 dairy and meat samples were collected for the study, and Staphylococcus spp. were isolated using Mannitol salt phenol red agar. Antimicrobial susceptibility was evaluated using the Clinical and Laboratory Standards Institute’s microdilution method. Twenty-six resistant isolates were identified by 16S …

Corrigendum To “Mir-9-5p Alleviates The Development Of Abdominal Aortic Aneurysm By Regulating The Diff Egulating The Differentiation Of Cd4+Il-10+T Cells Entiation Of Cd4+Il-10+T Cells Via Tar Via Targeting The Cr Geting The Crosstalk Between Nr Osstalk Between Nrf2 And Nf- F2 And Nf-Κb Signaling Pathways” [Turkish Journal Of Biology 49 (4) 2025 380-391], Hongfu Liu, Jinyi Zhang, Lubin Li, Benxiang Yu, Chunlei Zhang, Wenqiang Niu, Yawen Cheng, Hengyang Dong, Yukun Zhang, Xinlin Luo, Yanlian Xiong, Yueming Wang

Turkish Journal of Biology

This corrigendum is to address an issue regarding the manuscript’s previous publication. The authors noticed that the representative flow cytometry image for the AAA group in Figure 3B, as well as the representative Histone H3 and β-actin Western blot bands in Figure 4A, were incorrectly used in the original published version of this paper and indicated that the relevant corrections do not affect the results or the conclusions of the study.To rectify this oversight and ensure the accuracy of the published work, the correct figures are included for your reference.

Link to the original article: https://doi.org/10.55730/1300-0152.2754

Physicochemical, Pharmacognostic Standardisation And Phytochemical Analyses Of The Homoeopathic Drug Justicia Adhatoda, Bibaswan Biswas, Satish Patel, Digvijay Verma, Satyajit Maity, Shilpi Singh, Paulami Majumdar, Narasimha Kumar Gv

Indian Journal of Research in Homoeopathy

Background: Justicia adhatoda (J. adhatoda), also well known as Vasaka in India is a medicinal plant chiefly used to treat respiratory ailments in traditional and alternative medical systems. Objective: This study aimed to establish the physicochemical, pharmacognostic, and phytochemical standardisation parameters of the drug. The study involved the measurement of physicochemical parameters and chemical profiling of the raw drug. The chemical characteristics of the in-house mother tincture (prepared from in-house raw drug) and commercial mother tinctures available in India were also evaluated to assess the quality of commercially available mother tinctures. Materials and Methods: The present study …

Indian Standard For Globules Used In Homoeopathy, Kumar Vivekanand, Daisy Katarmal, Indra Gaurav Saxena, Divya Taneja, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

This article aims to describe and critically examine the Indian Standard (IS 18947:2024) for globules used in Homoeopathy, outlining the technical specifications, testing methods, and significance for pharmaceutical quality assurance. The implications of the standard for manufacturers, quality control laboratories, consumers and regulatory bodies engaged in the production and evaluation of homoeopathic drugs are highlighted by presenting a consolidated view of the standard's scope and applications. This discussion underscores the continued importance of systematic standardization in ensuring the safety, consistency, and global credibility of homoeopathic medicinal products produced in India.

Research Highlights, Kusum Lata, Ekta Agrawal

Indian Journal of Research in Homoeopathy

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Guiding Principles For Teaching About Genocide And Other Difficult Pasts, Kerry E. Whigham

Genocide Studies and Prevention: An International Journal

This article outlines guiding principles for teaching “difficult pasts”—episodes of large-scale, identity-based violence such as genocide, crimes against humanity, colonialism, and enslavement—in ways that promote peace, human rights, and the prevention of future atrocities. Drawing from the fields of Holocaust and Genocide Education (HGE), Global Citizenship Education (GCED), Peace Education (PE), and Human Rights Education (HRE), it argues that instruction should move beyond the memorization of historical facts toward developing students’ socio-emotional and behavioral capacities to recognize and resist processes of othering, discrimination, and violence. The brief presents three main areas of guidance: curricular content, emphasizing conceptual understanding over rote …

Book Review: The Role Of Civil Society In Transitional Justice: The Case Of Russia, Myra Dahgaypaw

Genocide Studies and Prevention: An International Journal

This book review evaluates Selbi Durdiyeva's The Role of Civil Society in Transitional Justice: The Case of Russia as a vital contribution to genocide prevention scholarship, which is particularly timely given Russia's mass atrocity crimes in Ukraine and their connection to domestic repression. The book's theoretical innovation in challenging state-centric transitional justice paradigms through rigorous analysis of Memorial NGO, Orthodox Church activities, and revisionist groups across three decades of post-Soviet Russia is critical for the transitional justice field. It is worth highlighting Durdiyeva's unique postcolonial perspective as someone from a former Soviet territory studying the metropole, and her demonstration that …

Book Review: Research Handbook On The Punishment Of Atrocity Crimes, Bryant Lyttle

Genocide Studies and Prevention: An International Journal

No abstract provided.

Book Review: The Death In Their Eyes: What Perpetrator Images Perpetrate, Libertad Gills

Genocide Studies and Prevention: An International Journal

No abstract provided.

Concentric Macular Rings And Oct Corrugations In Foveal Hypoplasia: Proof Of Concept For An Optical Interference Mechanism, Ari August, Ralph Eagle, Tatyana Milman, Rebecca Procopio, Bruce Schnall, Jose Pulido

Wills Eye Hospital Papers

BACKGROUND: Concentric macular rings (CMR) and Henle fiber layer (HFL) corrugations, potential clinical biomarkers of foveal hypoplasia, have been observed in laser fundus photographs and optical coherence tomography (OCT) images, respectively. Some believe these findings represent true anatomical structural changes while others hypothesize that they are artifacts of interference; however, to our knowledge, no previous study has provided evidence to support either theory.

METHODS: This retrospective case series analyzed CMR and OCT corrugations in 3 patients (6 eyes) with foveal hypoplasia. Dark fringe diameters of CMR at different wavelengths (λ: red = 635, green = 532, blue = 488 nm) …

Perspectives On Implementing Environmentally Sustainable Practices In Cataract Surgeries: Interviews Of Administrative And Frontline Healthcare Workers, Daniel Parra, Brooke Sherry, Emma Pak, Lauren Taylor, Erin S. Rogers, Sarah E. Hochman, Maria De Los Angeles Ramos Cadena, Joel S. Schuman, Christina R. Prescott, Cassandra L. Thiel

Wills Eye Hospital Papers

BACKGROUND: Healthcare is responsible for 8.5% of greenhouse gas emission in the United States. Physicians are becoming increasingly concerned about the climate crisis, particularly in the field of ophthalmology where there is a growing body of literature related to sustainability. Although emissions of cataracts surgery, one of the most performed surgical procedures in the world, have been quantified, modifications to practice have yet to be made. This study aims to uplift the perspectives of a diverse set of healthcare workers on implementing environmentally sustainable practices in the cataract surgery setting.

METHODS: 16 semi-structured interviews were conducted with professionals working in …

Effect Of Stages Of Prehospital Hypertensive Crisis And Length-Of-Stay On Acute Stroke Readmission, Thomas Bob Ross Phd

Walden Dissertations and Doctoral Studies

Stroke is the second leading cause of mortality and the third leading cause of disability, affecting over 800,000 Americans annually. Traditional stroke research has focused on in-hospital settings, but not on prehospital stroke admissions, despite evidence that over 75% of acute stroke cases managed by emergency medical services involve prehospital hypertensive crises (HTN-C). HTN-C is classified into three systolic blood pressure (SBP) stages: Stage 1 (140–159 mm Hg), Stage 2 (160–179 mm Hg), and Stage 3 (≥180 mm Hg), the latter associated with organ damage. Hypertension correlates with longer hospital stays and more intensive interventions in hospitalized patients, but HTN-C …

Dental Students' Perceptions Of Patient Safety: A Cross-Sectional Study Using The Traditional Chinese Version Of The Attitudes To Patient Safety Questionnaire, Chen-Yi Lee, Ju-Hui Wu, Yu-Chih Lin, Shu-Yuan Lin

Journal of Medical Education

Objectives: This study aimed to examine the psychometric properties of the traditional Chinese version of the Attitudes to Patient Safety Questionnaire (APSQ-T) in a Taiwanese population (Study 1) and investigate dental students' perceptions of patient safety, identify their educational needs, and correlate these aspects to improve the curriculum (Study 2). Methods: Study 1 conducted a cross-sectional study using convenience sampling at a medical university in Taiwan. A total of 223 participants from the fields of dentistry, oral hygiene, nursing, and medicine were recruited to complete an anonymous survey for the validation of the APSQ-T. In Study 2, data collected from …

Reexamining The Abraham Accords: The Dynamics Of The Abraham Alliance Amid Geopolitical Uncertainly, Wahyu Dwi Pambagyo, Ali Maksum

Journal Of Middle East and Islamic Studies

Several studies have discussed the bilateral economic impact of the Abraham Accords, but few of them have thoroughly examined how this agreement has evolved into a collective security framework amid global geopolitical changes. This study attempts to fill the existing research gap by analyzing the transformation of the Abraham Accords into the Abraham Alliance using the Balance of Power theory framework developed by Stephan M. Walt. Using a qualitative approach and case study mode, this study examines secondary data from 2020 to 2025, using academic journals, government policy documents, and reliable news media as sources. This study concludes that the …

Digital Zakat And Islamic Fintech: A Bibliometric Analysis Of Global Research Trends And Collaboration Networks (2012–2025), Muhamad Dupi, Fauziyah Adzimatinur

Journal Of Middle East and Islamic Studies

This paper examines global research trends, collaborative networks, and prevailing themes in digital zakat and Islamic fintech studies published from 2012 to 2025. We retrieved a total of 194 Scopus-indexed publications using bibliometric methods on September 23, 2025, and analyzed them using VOSviewer version 1.6.20. The analysis set a minimum occurrence threshold of 5 for keywords and a minimum citation threshold of 10 for documents. The results indicate that the number of publications has been steadily rising since 2017, with the most in 2023 (42 documents). Malaysia, Indonesia, and Nigeria were the top contributors, and INCEIF University and the International …

QawāʿId Al-Fiqh On Government Energy Subsidies: Controlling Inflation Amid Economic Recovery, Nuzulul Firdaus, Nur Fatwa

Journal Of Middle East and Islamic Studies

The war between Russia and Ukraine significantly affected world life, one of which was the increase in world oil energy prices. Indonesia, in this case, which still imports a lot of energy, is also affected. The government needs to implement policies to face these global challenges, one of which is to provide subsidies for energy so that state budget funds can assist people's purchasing power for energy because if not, this will lead to an increase in the prices of goods and services so that there will be inflation. Still, on the other hand, Indonesia is also carrying out a …

A New Dioecious Bush Tomato, Solanum Nectarifolium (Solanaceae), From The Northern Tanami Desert, Northern Territory, Australia, With Reassessment Of S. Ossicruentum And A Change In The Circumscription Of S. Dioicum, Christopher T. Martine, Kym Brennan, Jason T. Cantley, Aiden Webb, Geoffrey Newton

Faculty Journal Articles

A new species of functionally dioecious bush tomato from the “Solanum dioicum + S. echinatum group” of Solanum subgenus Leptostemonum is described. Solanum nectarifolium Martine & Brennan, sp. nov., is a member of the taxonomically challenging Solanum dioicum W.Fitzg. species complex in Australia and differs from other species in the group by the presence of prominent and conspicuous extrafloral nectaries on the abaxial leaf surfaces, a tinge of purple on the new growth and young fruiting calyces, and curved prickles on young stems. Although fairly well represented in herbarium collections, this new taxon has historically been treated as a …

Development Of A High-Doppler Shift Optical Simulator To Test Femtosecond-Level Optical Time-Frequency Transfer, Matthew S. Bigelow, Kyle W. Martin, Nolan Matthews, Benjamin K. Stuhl, Richard Gonzales, Alexandre De Pinho E Braga, John Elgin, Kimberly A. Frey

Space Dynamics Laboratory Publications

We have developed an optical simulator to test real-time optical two-way time–frequency transfer at the femtosecond level capable of simulating relative motion between two linked optical clock nodes up to Mach 1.8 with no moving parts. The technique is enabled by artificially Doppler shifting femtosecond pulses from auxiliary stabilized optical frequency combs. These pulses are exchanged between the nodes to simulate the Doppler shifts observed from a changing optical path length. We can continuously scan the simulated velocity from 14 to 620 m s⁻¹ while simultaneously measuring velocity-dependent clock shifts at much higher velocities than previously recorded. This system …

What’S Happening: Nyls At The 2026 Aals Annual Meeting, Anthony W. Crowell

NYLS Community News

No abstract provided.

Konsumenckie Usługi Finansowe W Świetle Najnowszego Orzecznictwa Sądów Polskich (Wybrane Przykłady), Edyta Rutkowska-Tomaszewska, Marta Fabiszewska

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

This study contains an overview of Polish case law and aims to present selected judgments of common courts and the Supreme Court issued between 2023 and 2025 concerning the enforcement of consumer protection laws in the financial services market, in the most ‘active’ areas of recent times that are of relevance to legal practice. It presents judgments relating to four main issues, i.e. so-called free credit sanctions, unauthorised payment transactions, mortgage loans linked to foreign currencies, and loans where the interest rate mechanism is based on the WIBOR index.

Systemy Ochrony Instytucjonalnej W Sektorze Bankowym – W Świetle Rozporządzenia Crr, Rozdziału 10a Prawa Bankowego Oraz Regulacji Banków Spółdzielczych, Marta Stepniewska

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

This article is devoted to a discussion of the Institutional Protection Scheme (IPS) model, in the context of both EU and national legislation. The following sections discuss the legal and economic aspects of IPS. The largest such system in Europe – the German savings bank system – is used as the main example in the paper, while the comparative analysis also covered models from Italy, Austria and Spain.

With regard to Polish law, analyzed in detail were self-help mechanisms in the sector of cooperative banks, in operation since 2015, which represent modern solutions for the protection of solvency and liquidity …

Entire Issue Vol. 14 No. 4

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Vol 14(4)

Black Bone Mri Morphometry For Mandibular Cortical Bone Measurement In Head And Neck Cancer Patients: Prospective Method Comparison With Ct, Lisanne V Van Dijk, Juan Ventura, Kareem A Wahid, Lin L Zhu, Brigid A Mcdonald, Sara Ahmed, Keith L Sanders, Sonja M Stieb, Lance Mccoy, Christina S Sharafi, Kathryn E Preston, Natalie A West, Sarah Mirbahaeddin, Dina M El-Habashy, Travis Salzillo, Samuel Mulder, Joly Fahim, Aubryane Dearmas, Mona Arbab, Yao Ding, Jihong Wang, Bastien Rigaud, Anando Sen, Mark Chambers, Katherine A Hutcheson, Kristy K Brock, Abdallah S R Mohamed, Stephen Y Lai, Clifton D Fuller

Faculty, Staff and Student Publications

Objectives: Determine the utility of low-flip angle "black bone" magnetic resonance imaging (MRI) for cortical mandibular bone assessment compared to computed tomography (CT).

Methods: Quantification of cortical mandibular bone width was performed per Hamada et al. at 15 cross-sectional interdentium locations on pretreatment black bone MRI and CT for 15 oropharyngeal cancer patients, with interobserver analyses on a subset of three patients by 11 observers. CT and MRI measurements were compared using Bland-Altman analysis, Lin's concordance, and Deming regression; interobserver variability was assessed with absolute variance and intraclass correlation coefficient (ICC).

Results: Bland Altman and Deming regression analyses showed CT …

Sex Differences In Bile Acid Homeostasis And Excretion Underlie The Disparity In Liver Cancer Incidence Between Males And Females, Megan E Patton, Sherwin Kelekar, Lauren J Taylor, Angela E Dean, Qianying Zuo, Rhishikesh N Thakare, Sung Hwan Lee, Emily C Gentry, Morgan Panitchpakdi, Pieter Dorrestein, Yazen Alnouti, Zeynep Madak-Erdogan, Ju-Seog Lee, Milton J Finegold, Sayeepriyadarshini Anakk

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC), the common liver cancer, exhibits higher incidence in males. Here, we report that mice lacking bile acid (BA) regulators, Farnesoid X Receptor (FXR also termed NR1H4) and Small Heterodimer Partner (SHP also termed NR0B2), recapitulate the sex difference in liver cancer risk. Since few therapeutic options are available, we focused on understanding the intrinsic protection afforded to female livers. Transcriptomic analysis in control and NR1H4 and NR0B2 double knockout livers identified female-specific changes in metabolism, including amino acids, lipids, and steroids. To assess translational relevance, we examined if transcriptomic signatures obtained from this murine HCC model correlate …

Barriers To Digital Payment Adoption In Saudi Arabia: A Plithogenic Indetermhypersoft Complex Refined Modelling Approach, Mohanned H. Alharbi

Sustainable Machine Intelligence Journal

Digital payments are central to Saudi Arabia's financial modernization under Vision 2030. While infrastructure and regulations have advanced rapidly, adoption is still hindered by barriers such as security concerns, unclear costs, usability issues, and religious ambiguity. Standard analytical models often struggle to evaluate these barriers because user feedback is frequently incomplete, conflicting, or vague. To address this uncertainty, this paper proposes a new decision-making framework: the Plithogenic IndetermHyperSoft Complex Refined Neutrosophic model (PIHCRN-DPA). This model integrates advanced mathematical concepts to handle complexity. It uses refined neutrosophic sets to process degrees of truth and indeterminacy, while complex sets account for contextual …

Sustainable Framework For Performance-Based Learning Assessment Under Uncertainty: Computational Modeling, Mona Gharib, Muhammad Imran, Zaka Ur Rehman

Sustainable Machine Intelligence Journal

Evaluating performance-based learning, such as dance or performing arts education, poses significant computational challenges due to uncertainty, subjectivity, and heterogeneous evaluation data. Conventional scoring models fail to capture the coexistence of quantitative indicators (timing, attendance) and qualitative judgments (artistry, expressiveness).

This study introduces a computational neutrosophic functional framework that models ambiguity using set-valued, indeterminate representations within a rigorous analytic structure. We construct a neutrosophic function space CN(X) and a Hilbert C*-module HN for integrating evaluator signals through algebraic fusion. A strongly continuous neutrosophic operator semigroup (T(t)) is developed to model temporal …

The M-Clean Graph Of A Finite Commutative Ring, Susan F. El-Deken, Harald Fripertinger, Aya Gamal

Sustainable Machine Intelligence Journal

We study m-clean graphs of finite commutative rings R, which are a generalization of clean graphs. Their vertices are pairs of m-potent elements and units of R. These graphs can be described as Cartesian sums or co-normal products of two graphs. In particular we explore under which conditions the subgraph involving only non-zero m-potent elements is connected and we determine the degrees of its vertices. Moreover, we characterize under which conditions on two rings the corresponding m-clean graphs are isomorphic.

Detection Of Ultra-Trace Levels Of Copper In Seawater Using A Bare Gold Microwire Electrode And A Portable Digital Voltammeter, Luke M. Brosnan, Wade Lonsdale, Paul Pringle, Paul Lewtas, Samantha Ridgway, Sebastien Allard, Magdalena Wajrak

Research outputs 2022 to 2026

The accumulation of biomass on ship hulls (biofouling) can greatly decrease their fuel efficiency. Many antifouling coatings contain copper as a biocidal agent, which can be released during hull cleanings and is of particular concern when cleaning the hulls in situ (i.e., without dry docking). Previously established voltammetric methods for the detection of copper in seawater using a gold microwire electrode have been modified and adapted to a portable on-site voltammetric technique. Notable differences from previous voltammetric methods include the use of linear sweep voltammetry, analysis under atmospheric conditions, alternating the potential during the deposition period and the use of …

Caster V. Chelsea Hotel Owner, Llc

All Decisions

The Supreme Court granted the landlord's motion for summary judgment, dismissing the tenant's complaint. The tenant sued for breach of contract, seeking a leasehold in an adjacent unit, and for breach of the implied covenant of good faith and fair dealing. Both claims were dismissed due to the tenant's lack of evidentiary proof and the duplicative nature of the covenant claim. The tenant's harassment claim, based on alleged failure to repair and service disruptions, was barred by res judicata and collateral estoppel, as these issues were fully litigated as an affirmative defense in a prior non-payment action. The harassment claim …