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2025

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Second Look Commission 2025 Annual Report, Tennessee. Commission On Children And Youth. Dec 2025

Second Look Commission 2025 Annual Report, Tennessee. Commission On Children And Youth.

Second Look Commission Annual Report

No abstract provided.


Eucommia Ulmoides Extract Attenuates Oxidative Stress And Promotes Melanogenesis Via Wnt/Β-Catenin Signaling In B16 Cells And Mice, Xiaojin Liu, Yaqian Qiu, Xiaobing Lv, Lei Chang, Tiancheng Ji, Yefan Gu, Shuyue Chen Dec 2025

Eucommia Ulmoides Extract Attenuates Oxidative Stress And Promotes Melanogenesis Via Wnt/Β-Catenin Signaling In B16 Cells And Mice, Xiaojin Liu, Yaqian Qiu, Xiaobing Lv, Lei Chang, Tiancheng Ji, Yefan Gu, Shuyue Chen

Turkish Journal of Biology

Background/aim: Oxidative stress is a major contributor to melanocyte dysfunction and hair graying by impairing key signaling pathways. Eucommia ulmoides bark extract (EUE), rich in antioxidant phytochemicals, has shown potential in combating oxidative damage. This study investigated the protective and promelanogenic effects of EUE under hydrogen peroxide (H₂O₂)-induced oxidative stress, with a focus on the Wnt/β-catenin signaling pathway. Materials and methods: An oxidative stress model was established using B16 cells and a C57BL/6 mouse hair follicle model. Results: EUE significantly improved melanocyte survival and reduced intracellular reactive oxygen species (ROS). Mechanistically, EUE activated the Wnt/β-catenin pathway, leading to upregulation of …


Effects Of Different Perfluoroalkyl Substances On Rice Morphology, Physiology, And Biochemistry, Maryam M. Alomran, Muhammad Aqeel, Noreen Khalid, Noreen Akhter, Muhammad Kashif Irshad, Suliman Mohammed Suliman Alghanem, Fahad Mohammed Alzuaibr, Saher Nawaz, Omar Mahmoud Alzoubi, Muhammad Usman Akbar, Ali Noman Dec 2025

Effects Of Different Perfluoroalkyl Substances On Rice Morphology, Physiology, And Biochemistry, Maryam M. Alomran, Muhammad Aqeel, Noreen Khalid, Noreen Akhter, Muhammad Kashif Irshad, Suliman Mohammed Suliman Alghanem, Fahad Mohammed Alzuaibr, Saher Nawaz, Omar Mahmoud Alzoubi, Muhammad Usman Akbar, Ali Noman

Turkish Journal of Agriculture and Forestry

Perfluoroalkyl substances (PFASs) are synthetic organic compounds that have not been extensively studied in natural environments. The current study aimed to explore how PFASs, including perfluorooctane sulfonic acid (PFOS), perfluorobutane sulfonate (PFBS), perfluorohexanoate (PFHxA), perfluorotetradecanoate (PFTeDA), and perfluorobutanoate (PFBA), affect rice plants and influence their metabolism. These substances had a notable impact on root and shoot growth, reducing fresh and dry weights across various treatments compared to the control. These attributes were the least affected by PFOS treatment. PFBA treatment had significant adverse effects on chlorophyll a, b, and total chlorophyll levels, followed by the effects of PFHxA and PFTeDA. …


A New Longidoridae Member, Xiphinema Brevicolle, From Citrus Orchards In Türkiye, Adem Özarslandan, Ayşenur Aslan, Lerzan Öztürk Dec 2025

A New Longidoridae Member, Xiphinema Brevicolle, From Citrus Orchards In Türkiye, Adem Özarslandan, Ayşenur Aslan, Lerzan Öztürk

Turkish Journal of Agriculture and Forestry

Individuals of the genus Xiphinema were recovered from soil samples collected during citrus surveys in south-eastern Türkiye. Morphological examination using light microscopy identified the species as X. brevicolle. The female individuals measured 2000–2050 μm in length, and displayed a slightly flattened lip region, an amphidelphic reproductive system with two well-developed branches, and a short conoid tail ending in a rounded tip. These morphometric and morphological features were consistent with those of previously described X. brevicolle specimens. For molecular confirmation, the D2–D3 segment of the 28S rDNA was amplified using the D2AD3B primer pair, and sequenced; the resulting sequence has been …


Full Issue 19.2 Dec 2025

Full Issue 19.2

Genocide Studies and Prevention: An International Journal

No abstract provided.


Arts & Literature: Cursed, Nadeem Zaman Dec 2025

Arts & Literature: Cursed, Nadeem Zaman

Genocide Studies and Prevention: An International Journal

No abstract provided.


หลักความคาดหวังอันชอบธรรมในกฎหมายปกครอง: พัฒนาการ แนวคิดเชิงเปรียบเทียบ และบทวิเคราะห์สำหรับประเทศไทย (The Principle Of Legitimate Expectations In Administrative Law: Development, Comparative Concepts, And Analysis For Thailand), Paphanphon Paphangkornphurin Dec 2025

หลักความคาดหวังอันชอบธรรมในกฎหมายปกครอง: พัฒนาการ แนวคิดเชิงเปรียบเทียบ และบทวิเคราะห์สำหรับประเทศไทย (The Principle Of Legitimate Expectations In Administrative Law: Development, Comparative Concepts, And Analysis For Thailand), Paphanphon Paphangkornphurin

Chulalongkorn University Law Journal

หลักความคาดหวังอันชอบธรรมเป็นกลไกสำคัญในระบบกฎหมายปกครองสมัยใหม่ที่มุ่งคุ้มครองความไว้วางใจของประชาชนต่อการกระทำของรัฐ บทความนี้ศึกษาพัฒนาการและสาระสำคัญของหลักการดังกล่าวในระบบกฎหมายเปรียบเทียบ ได้แก่ ระบบกฎหมายเยอรมนีที่หลักความคาดหวังอันชอบธรรมได้รับการยอมรับเป็น “หลักรัฐธรรมนูญทั่วไป” ภายใต้หลักนิติรัฐ และเชื่อมโยงกับหลักความมั่นคงแน่นอนทางกฎหมายและหลักความได้สัดส่วน ในอังกฤษหลักนี้มีจุดเริ่มต้นจากแนวคิดเรื่องความเป็นธรรมในกระบวนการก่อนขยายไปสู่การคุ้มครองผลประโยชน์เชิงเนื้อหาโดยใช้หลักการถ่วงดุลกับประโยชน์สาธารณะ ส่วนประเทศอื่น เช่น ออสเตรเลีย แคนาดา โปแลนด์ อินเดีย และฝรั่งเศส ต่างมีลักษณะการปรับใช้เฉพาะที่สะท้อนเป้าหมายร่วมกันในการจำกัดอำนาจรัฐและคุ้มครองความไว้วางใจของประชาชน สำหรับประเทศไทย ศาลปกครองไทยได้วางหลักการตีความสำคัญหลายประการทั้งการคุ้มครองเชิงเนื้อหาที่รับรองฐานะทางกฎหมายแม้คำสั่งจะถูกเพิกถอนในภายหลัง การชั่งน้ำหนักระหว่างความคาดหวังส่วนบุคคลกับประโยชน์สาธารณะ การเชื่อมโยงหลักความคาดหวังอันชอบธรรมกับหลักนิติรัฐ ข้อยกเว้นกรณีประมาทเลินเล่อร้ายแรงและการปกปิดข้อเท็จจริงที่มีสาระสำคัญ อย่างไรก็ตาม การปรับใช้ยังขาดความสม่ำเสมอในสาระสำคัญของการคุ้มครองความไว้วางใจของประชาชน บทความจึงนำเสนอแนวทางการพัฒนากฎหมายปกครองไทย ทั้งการปรับปรุงกฎหมายที่มีอยู่ให้ครอบคลุมรูปแบบความคาดหวังที่หลากหลาย การพัฒนาแนวทางการตีความของศาลที่ยอมรับการคุ้มครองทั้งในเชิงกระบวนการและเชิงเนื้อหา และการสร้างกลไกทางกฎหมายใหม่ เช่น คณะกรรมการไกล่เกลี่ยข้อพิพาท อันจะนำไปสู่การพัฒนาระบบกฎหมายปกครองไทยที่เป็นธรรม โปร่งใส และสอดคล้องกับหลักนิติรัฐอย่างแท้จริง


The Art And Science Of Healing: Reframing The Healer's Mindset For The Human-Ai Era, Jen-Hung Yang Dec 2025

The Art And Science Of Healing: Reframing The Healer's Mindset For The Human-Ai Era, Jen-Hung Yang

Journal of Medical Education

Background: AI's expansion in medicine sharpens the tension between diagnostic science and the art of healing. AI is a complex sociotechnical system. Its integration in medicine is accelerating, yet reactive and tool-driven, which offers both opportunities and risks. AI will potentially worsen depersonalization and burnout. Objectives: The aim is to develop the guiding principles of AI to strengthen the art healing in medical education. Innovations: Healer's Mindset, inspired by Gardner's Five Minds, reframes Respectful and Ethical minds as three pillars: critical validation, a humanistic core, and discerning augmentation. These principles can help AI restore medicine's essence: fostering inquiry, faculty …


Choosing Who To Be: Teaching Ethics Through Value Conflicts And Identity Reflection, Jennifer Kwon, Hsingchi Von Bergmann Dec 2025

Choosing Who To Be: Teaching Ethics Through Value Conflicts And Identity Reflection, Jennifer Kwon, Hsingchi Von Bergmann

Journal of Medical Education

Background: This study introduces a reflective learning approach that combines ethical dilemmas with axiological analysis to explore how students' value hierarchies shape their professional identity formation. Moving beyond traditional frameworks such as Principlism, this approach invites learners to examine the tensions between personal and professional values, encouraging critical reflection on how their decisions relate to multiple identities and evolving professional commitments. Methods: Two open-ended ethical dilemmas were distributed via an anonymous online survey using Qualtrics. This method was intentionally chosen to elicit narrative responses from a large cohort of students while providing space for candid reflection on complex, value-laden situations. …


Evaluating Self-Efficacy In Pharm.D. And B.S. Pharmacy Programs: A Repeated Cross-Sectional Study, Jia-An Hung, Kuan-Lin Chen, Yen-Ming Huang, Li-Jiuan Shen, Fei-Yuan Hsiao, Chia-Yi Wu, Fe-Lin Lin Wu, Chi-Chuan Yeh, Shu-Wen Lin Dec 2025

Evaluating Self-Efficacy In Pharm.D. And B.S. Pharmacy Programs: A Repeated Cross-Sectional Study, Jia-An Hung, Kuan-Lin Chen, Yen-Ming Huang, Li-Jiuan Shen, Fei-Yuan Hsiao, Chia-Yi Wu, Fe-Lin Lin Wu, Chi-Chuan Yeh, Shu-Wen Lin

Journal of Medical Education

Background: Pharmacy education in Taiwan has shifted from a four-year Bachelor of Science (B.S.) degree to a six-year Doctor of Pharmacy (Pharm.D.) degree emphasizing patient-centered competencies. This study evaluated the self-efficacy of pharmacy students at different stages of the programs. Methods: A repeated cross-sectional survey was conducted from 2017 to 2019 at a university in Taiwan. Third- to sixth-year Pharm.D. and fourth-year B.S. students completed a validated 53-item self-efficacy scale comprising five domains. Data were analyzed using ANOVA, repeated-measures ANOVA, and Kruskal–Wallis one-way analysis to evaluate differences in students' self-efficacy scores across academic years and between different programs. Results: Among …


Impact Of Flipped Classroom And Virtual Reality On Dental Students' Local Anesthesia Training, Yu-Wei Chiu, Ming-Yi Lu, Chih-Yu Peng, Yi-Tzu Chen Dec 2025

Impact Of Flipped Classroom And Virtual Reality On Dental Students' Local Anesthesia Training, Yu-Wei Chiu, Ming-Yi Lu, Chih-Yu Peng, Yi-Tzu Chen

Journal of Medical Education

Background and Objective: The goal of this study was to evaluate the impact of flipped classroom teaching and virtual reality (VR) on fourth-year dental students' comprehension of procedures and concepts in local anesthesia courses. Methods: The School of Dentistry at Chung Shan Medical University created a VR simulation that guided students through an inferior alveolar nerve block anesthesia procedure using HTC Vive headsets. Following traditional classroom lectures, students of the academic year 2022 participated in VR simulations and one-on-one practice, which was supplemented by instructional videos. Performance was assessed using a checklist, and feedback was collected via questionnaires. Results: Eighty-two …


Expanding The Horizon Of Pocus Education: Integrating Nutritional Ultrasound Into Interprofessional Critical Care Training, Shih-Ching Lo, Chien-Wei Liu, Hsing-Chun Lin Dec 2025

Expanding The Horizon Of Pocus Education: Integrating Nutritional Ultrasound Into Interprofessional Critical Care Training, Shih-Ching Lo, Chien-Wei Liu, Hsing-Chun Lin

Journal of Medical Education

No abstract provided.


Microglial Expression Of Serotonin Receptors Reveals Parallel Regulation Of 5-Ht2b And Bdnf In The Rat Hippocampus, Andrei Turkin, Maria Sidorova, Ekaterina Kurilova, Natalia Alenina, Oksana Tuchina, Friederike Klempin Dec 2025

Microglial Expression Of Serotonin Receptors Reveals Parallel Regulation Of 5-Ht2b And Bdnf In The Rat Hippocampus, Andrei Turkin, Maria Sidorova, Ekaterina Kurilova, Natalia Alenina, Oksana Tuchina, Friederike Klempin

School of Graduate Studies Faculty Publications

Growing evidence suggests that psychiatric disorders are characterized by a prolonged inflammatory state, which may influence the efficacy of compounds targeting serotonin. Serotonin is a key signaling molecule in neuroplasticity of the adult hippocampus and involved in antidepressant action. Recent in vitro studies indicate the neurotransmitter may also facilitate the response to inflammation and potentially modulate microglial function towards neuroprotection. Using Tph2−/− rats depleted of brain serotonin, we examined microglial expression of various serotonin receptors (5-HTRs) in vivo in both the hippocampus and prefrontal cortex and assessed mRNA levels of cytokines and brain-derived neurotrophic factor (BDNF). We observed age-dependent and …


Cover And Contents Dec 2025

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.


Utilization Of Phytogenic Silver Nanoparticles And Bacterial Agents For The Management Of Citrus Canker Disease, Zainab Jamil, Tariq Mukhtar, Muhammad Usman Raja, Muhammad Shahbaz, Jaya Seelan S. Seelan, Muhammed Tatar, Amjad Ali, Noor Fatima, Rahma Bejaoui, Ayşe Usanmaz Bozhüyük Dec 2025

Utilization Of Phytogenic Silver Nanoparticles And Bacterial Agents For The Management Of Citrus Canker Disease, Zainab Jamil, Tariq Mukhtar, Muhammad Usman Raja, Muhammad Shahbaz, Jaya Seelan S. Seelan, Muhammed Tatar, Amjad Ali, Noor Fatima, Rahma Bejaoui, Ayşe Usanmaz Bozhüyük

Turkish Journal of Agriculture and Forestry

Citrus is one of the most important and widely cultivated fruit crops globally. However, its productivity is increasingly threatened by various diseases, with bacterial infections being particularly the most destructive. Among these, citrus canker, caused by Xanthomonas axonopodis pv. citri (Xac), poses a significant challenge, requiring effective management strategies. Traditional approaches have shown limited success, but nanotechnology has emerged as a promising alternative for disease control. In this study, Xanthomonas spp. was isolated from two locations: Koont Farm and the National Agricultural Research Centre (NARC) citrus orchards in Islamabad, Pakistan. The isolates were identified through morpho-biochemical methods. Moreover, three Bacillus …


Effects Of Different Mixing Ratios Of Common Vetch And Oats On Forage Yield And Quality, Meli̇h Okcu, Sedat Severoğlu, İbrahi̇m Kavuncu Dec 2025

Effects Of Different Mixing Ratios Of Common Vetch And Oats On Forage Yield And Quality, Meli̇h Okcu, Sedat Severoğlu, İbrahi̇m Kavuncu

Turkish Journal of Agriculture and Forestry

This study investigates the optimal mixing ratios of common vetch (Vicia sativa L., CV) and oats (Avena sativa L., O) for enhanced forage yield and quality in the ecological conditions of Erzurum Province. The research was conducted over two growing seasons with three replications in a randomized complete block design (RCBD). Specifically, three common vetch cultivars (Gülhan, Albayrak, Kubilay) and one oat cultivar (Kupa) were evaluated by sowing as sole crops and in different ratios (25% vetch + 75% oat, 50% vetch + 50% oat, 75% vetch + 25% oat). The analyzed parameters included hay forage yield (HFY), dry matter …


Optimizing Cultivated Land Productivity Through Integrated Fertilization Strategies And Uav-Assisted Management, Kejun Wang Dec 2025

Optimizing Cultivated Land Productivity Through Integrated Fertilization Strategies And Uav-Assisted Management, Kejun Wang

Turkish Journal of Agriculture and Forestry

This study investigates the impact of long-term fertilization modes on crop health and productivity using unmanned aerial vehicle (UAV)-assisted monitoring and a Q-learning-based approach for optimized fertilization strategies. An approximate state-matching Q-learning algorithm was developed to improve the efficiency of agricultural UAVs in fertilization tasks. The spatiotemporal patterns of cultivated land productivity under different fertilization regimes were analyzed in a long-term experiment. An evaluation system for cultivated land health productivity was established. The results indicated that the Q-learning algorithm enabled UAVs to achieve efficient task completion. QLASM outperformed traditional methods on all metrics. QLASM achieved a 92% task completion rate …


The State Of The Child In Tennessee 2025, Tennessee. Commission On Children And Youth. Dec 2025

The State Of The Child In Tennessee 2025, Tennessee. Commission On Children And Youth.

The State of the Child in Tennessee

No abstract provided.


Subgroup Analyses Of The Phase 3 Focus Study Of Melphalan/Hepatic Delivery System In Patients With Unresectable Metastatic Uveal Melanoma, Jonathan S. Zager, Marlana Orloff, Pier Francesco Ferrucci, Junsung Choi, David J. Eschelman, Evan S. Glazer, Aslam Ejaz, Erika Richtig, Sebastian Ochsenreither, Sunil A. Reddy, Michael C. Lowe, Georgia M. Beasley, Anja Gesierich, Martin Gschnell, Reinhard Dummer, Ana Arance, Stephen William Fenwick, Joseph J. Sacco, Johnny John, Matthew Wheater, Christian H. Ottensmeier Dec 2025

Subgroup Analyses Of The Phase 3 Focus Study Of Melphalan/Hepatic Delivery System In Patients With Unresectable Metastatic Uveal Melanoma, Jonathan S. Zager, Marlana Orloff, Pier Francesco Ferrucci, Junsung Choi, David J. Eschelman, Evan S. Glazer, Aslam Ejaz, Erika Richtig, Sebastian Ochsenreither, Sunil A. Reddy, Michael C. Lowe, Georgia M. Beasley, Anja Gesierich, Martin Gschnell, Reinhard Dummer, Ana Arance, Stephen William Fenwick, Joseph J. Sacco, Johnny John, Matthew Wheater, Christian H. Ottensmeier

Department of Medical Oncology Faculty Papers

PURPOSE: To assess efficacy and safety in subgroups of patients treated with Melphalan/Hepatic Delivery System (melphalan/HDS), a drug/device combination for liver-directed treatment of metastatic UM (mUM) patients. Previously reported FOCUS study results indicated melphalan/HDS treatment provides a clinically meaningful response rate and favorable benefit-risk ratio in patients with unresectable mUM.

METHODS: Patients with mUM received treatment with melphalan (3.0 mg/kg ideal body weight) every 6-8 weeks for up to 6 cycles. Post hoc analyses of efficacy and safety were conducted for patient subgroups based on demographic and baseline disease characteristics.

RESULTS: 102 patients with mUM were enrolled; treatment was attempted …


Cross-Validated Probabilistic Bayesian Bert With Semantic Embedding Fusion For Robust Text Classification, Nabil M. Abdel-Aziz, Mahmoud Ibrahim, Khalid A. Eldrandaly Dec 2025

Cross-Validated Probabilistic Bayesian Bert With Semantic Embedding Fusion For Robust Text Classification, Nabil M. Abdel-Aziz, Mahmoud Ibrahim, Khalid A. Eldrandaly

Sustainable Machine Intelligence Journal

Sentiment Analysis is one of the most prominent branches of natural language processing. It deals with text classification to identify the public emotions and opinions which help businesses and political institutions make strategic decisions. This study proposes a sentiment classification model by integrating the Bayesian inference into the BERT transformer model, augmented with pre-trained GloVe embeddings. The primary objective is to refine sentiment analysis performance on IMDB movie reviews dataset by leveraging BERT's contextualized embeddings and the semantic richness of GloVe vectors, while incorporating Bayesian inference for uncertainty quantification. Using both 5-fold cross-validation and solo training, the model's performance was …


The Role Of Ai In Addressing The United Nations Sustainable Development Goals (Sdgs): A Comprehensive Survey, Walid Abdullah, Muhammad Nawaz, Basma Nasir, Muhammad Javed Ramzan Dec 2025

The Role Of Ai In Addressing The United Nations Sustainable Development Goals (Sdgs): A Comprehensive Survey, Walid Abdullah, Muhammad Nawaz, Basma Nasir, Muhammad Javed Ramzan

Sustainable Machine Intelligence Journal

Artificial Intelligence (AI) emerges as a transformative tool in addressing global challenges, particularly in achieving the United Nations Sustainable Development Goals (SDGs). This paper provides a comprehensive survey of how AI technologies contribute to addressing global challenges across social, economic, and environmental domains. By enabling advanced data analysis, predictive modeling, and automation, AI offers innovative solutions across sectors such as poverty reduction, healthcare, quality education, sustainable cities, climate action, and the protection of life on land and below water. Special attention is given to practical, real-world examples where AI enables more efficient resource management, predictive analytics, environmental monitoring, and data-driven …


Study On The Role Of Shenfu Injection In Mediating Ferroptosis Through The Akt/Gsk-3Β/Nrf2 Pathway In Yang-Deficient Chronic Heart Failure, Xiaojie Chen, Jiayun Guo, Bing Lin, Huamin Wang, Ziyu Lu, Bayi Liu Dec 2025

Study On The Role Of Shenfu Injection In Mediating Ferroptosis Through The Akt/Gsk-3Β/Nrf2 Pathway In Yang-Deficient Chronic Heart Failure, Xiaojie Chen, Jiayun Guo, Bing Lin, Huamin Wang, Ziyu Lu, Bayi Liu

Turkish Journal of Biology

Background/aim: The present study investigates the role of Shenfu injection in the treatment of yang-deficient chronic heart failure (CHF). Materials and methods: Sprague-Dawley (SD) rats were modeled for yang-deficient CHF by abdominal aortic coarctation. Echocardiography was performed to detect changes in cardiac function, and serum N-terminal B-type natriuretic peptide proteins (NT-proBNP), cardiac troponin I (cTnI), and ferroptosis-related factors were measured using ELISA kits. Pathological changes in cardiac tissues were observed through hematoxylin-eosin (HE) and Masson’ trichrome staining, cardiomyocyte apoptosis was measured by TUNEL staining, and reactive oxygen species (ROS) production was determined through dihydroethidium (DHE) staining. The expression of nuclear …


Identification Of Epigenetic Monotherapy Candidates In Taxane-Resistant Crpc, Buse Cevatemre, İpek Bulut, Ezgi̇ Karyemez, Ceyda Açilan Dec 2025

Identification Of Epigenetic Monotherapy Candidates In Taxane-Resistant Crpc, Buse Cevatemre, İpek Bulut, Ezgi̇ Karyemez, Ceyda Açilan

Turkish Journal of Biology

Background/aim: Taxane resistance remains a significant challenge in the effective treatment of castration-resistant prostate cancer (CRPC). Given the association of epigenetic regulation with chemotherapy resistance and cancer progression, this study aims to identify epigenetic vulnerabilities in two CRPC cell lines (DU145 and 22Rv1) established as resistant to two different taxanes, docetaxel (Dtx) and cabazitaxel (Cbz), using a small-molecule screening approach. Materials and methods: A small-molecule library targeting epigenetic regulators, including histone deacetylases (HDAC), histone methyltransferases, histone demethylases, bromodomain proteins, deoxyribonucleic acid methyltransferases, protein arginine deiminase, and histone acetyltransferase was utilized. Drug screening was performed on parental and taxane-resistant CRPC cell …


Mir-22 Inhibits The Proliferation, Migration, And Invasion Of Human Cd133-Positive Glioblastoma Stem Cells, Sevi̇l Köse, Özlenen Özkan, Ömer Özkan Dec 2025

Mir-22 Inhibits The Proliferation, Migration, And Invasion Of Human Cd133-Positive Glioblastoma Stem Cells, Sevi̇l Köse, Özlenen Özkan, Ömer Özkan

Turkish Journal of Biology

Background/aim: Glioblastoma multiforme (GBM) is one of the most aggressive and fatal malignancies of the central nervous system. Despite advancements in treatment strategies, effective therapies for GBM remain insufficient, necessitating further improvements. Notably, miR-22 has been found to be significantly downregulated in both glioblastoma tissues and cell lines. In this study, we aim to evaluate miR-22 expression levels in GBM (U87) and CD133-positive (CD133+) GBM stem cells (GSCs) and to investigate its effects on proliferation, colony formation, migration, invasion, and wound-healing in U87 and CD133+ U87 cells in vitro.Materials and methods: We isolated CD133+ U87 cells using magnetic-activated cell sorting …


Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng Dec 2025

Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng

Turkish Journal of Biology

Background/aim: Fibroblast Growth Factor Receptor (FGFR) gene fusions are recognized as pivotal oncogenic drivers, contributing to cancer initiation and progression across diverse malignancies. These fusions often represent significant therapeutic targets, particularly in challenging malignancies like cholangiocarcinoma. This study aimed to characterize the novel FGFR2::SHTN1 fusion, identify it as a de novo chimeric protein, and elucidate its precise oncogenic mechanism. Materials and methods: FGFR2::SHTN1 fusions were identified via cancer genomics databases and modeled using AlphaFold and HADDOCK. SHTN1 variants were expressed in Neuro-2a cells for coimmunoprecipitation, purification, and native polyacrylamide gel electrophoresis to assess oligomerization. Structural modeling included membrane embedding with …


Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak Dec 2025

Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak

Turkish Journal of Biology

Background/aim: This study aimed to investigate the phenotypic resistance and distribution of efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. isolated from dairy and meat samples. Antimicrobial resistance in foodborne bacteria increases with antibiotic exposure and biocides, particularly through efflux mechanisms. Thus, monitoring potential genetic reservoirs in the food chain is very important. Materials and methods: A total of 132 dairy and meat samples were collected for the study, and Staphylococcus spp. were isolated using Mannitol salt phenol red agar. Antimicrobial susceptibility was evaluated using the Clinical and Laboratory Standards Institute’s microdilution method. Twenty-six resistant isolates were identified by 16S …


Corrigendum To “Mir-9-5p Alleviates The Development Of Abdominal Aortic Aneurysm By Regulating The Diff Egulating The Differentiation Of Cd4+Il-10+T Cells Entiation Of Cd4+Il-10+T Cells Via Tar Via Targeting The Cr Geting The Crosstalk Between Nr Osstalk Between Nrf2 And Nf- F2 And Nf-Κb Signaling Pathways” [Turkish Journal Of Biology 49 (4) 2025 380-391], Hongfu Liu, Jinyi Zhang, Lubin Li, Benxiang Yu, Chunlei Zhang, Wenqiang Niu, Yawen Cheng, Hengyang Dong, Yukun Zhang, Xinlin Luo, Yanlian Xiong, Yueming Wang Dec 2025

Corrigendum To “Mir-9-5p Alleviates The Development Of Abdominal Aortic Aneurysm By Regulating The Diff Egulating The Differentiation Of Cd4+Il-10+T Cells Entiation Of Cd4+Il-10+T Cells Via Tar Via Targeting The Cr Geting The Crosstalk Between Nr Osstalk Between Nrf2 And Nf- F2 And Nf-Κb Signaling Pathways” [Turkish Journal Of Biology 49 (4) 2025 380-391], Hongfu Liu, Jinyi Zhang, Lubin Li, Benxiang Yu, Chunlei Zhang, Wenqiang Niu, Yawen Cheng, Hengyang Dong, Yukun Zhang, Xinlin Luo, Yanlian Xiong, Yueming Wang

Turkish Journal of Biology

This corrigendum is to address an issue regarding the manuscript’s previous publication. The authors noticed that the representative flow cytometry image for the AAA group in Figure 3B, as well as the representative Histone H3 and β-actin Western blot bands in Figure 4A, were incorrectly used in the original published version of this paper and indicated that the relevant corrections do not affect the results or the conclusions of the study.To rectify this oversight and ensure the accuracy of the published work, the correct figures are included for your reference.

Link to the original article: https://doi.org/10.55730/1300-0152.2754


นัยของพันธกรณีตามความตกลงระหว่างประเทศว่าด้วยการลงทุนต่อการทำหน้าที่ของศาลในการกำกับดูแลการอนุญาโตตุลาการทางพาณิชย์ระหว่างประเทศ (Implications Of International Investment Agreement’S Obligations On A Supervisory Function Of Domestic Courts Over International Commercial Arbitration), Chotika Wittayawarakul Dec 2025

นัยของพันธกรณีตามความตกลงระหว่างประเทศว่าด้วยการลงทุนต่อการทำหน้าที่ของศาลในการกำกับดูแลการอนุญาโตตุลาการทางพาณิชย์ระหว่างประเทศ (Implications Of International Investment Agreement’S Obligations On A Supervisory Function Of Domestic Courts Over International Commercial Arbitration), Chotika Wittayawarakul

Chulalongkorn University Law Journal

บทความวิจัยนี้ศึกษาพันธกรณีภายใต้ความตกลงระหว่างประเทศว่าด้วยการลงทุนที่เกี่ยวข้องกับการกระทำทางตุลาการ และแนวคำชี้ขาดของคณะอนุญาโตตุลาการที่ระงับข้อพิพาทระหว่างรัฐกับนักลงทุน เพื่อวิเคราะห์นัยของพันธกรณีของรัฐตามความตกลงดังกล่าวต่อการทำหน้าที่ของศาลโดยเฉพาะอย่างยิ่งในการกำกับดูแลการอนุญาโต ตุลาการทางพาณิชย์ มีหลายคดีที่นักลงทุนกล่าวหาว่าการกระทำของศาลในการกำกับดูแลการอนุญาโตตุลาการทางพาณิชย์ละเมิดพันธกรณีของรัฐตามความตกลงระหว่างประเทศว่าด้วยการลงทุน ซึ่งทำให้คณะอนุญาโตตุลาการต้องทบทวนคำพิพากษาและคำสั่งของศาลภายใน จากการศึกษาพบว่าคณะอนุญาโตตุลาการมีแนวโน้มที่จะยอมรับดุลพินิจของศาลภายใน กรณีที่ถือว่าการกระทำของศาลเป็นการละเมิดพันธกรณีตามความตกลงระหว่างประเทศว่าด้วยการลงทุนต้องเป็นกรณีที่การกระทำของศาลมีความบกพร่องอย่างร้ายแรงซึ่งพิจารณาจากมาตรฐานระหว่างประเทศ อนุสัญญาว่าด้วยการยอมรับนับถือและการบังคับตามคำชี้ขาดอนุญาโตตุลาการต่างประเทศ ค.ศ. 1958 มีบทบาทสำคัญในการพิจารณาความรับผิดของรัฐตามความตกลงระหว่างประเทศว่าด้วยการลงทุน


Strengthening Homoeopathy With Standards: The Bis Initiative, Raj K Manchanda, Kumar Vivekanand, Daisy Katarmal Dec 2025

Strengthening Homoeopathy With Standards: The Bis Initiative, Raj K Manchanda, Kumar Vivekanand, Daisy Katarmal

Indian Journal of Research in Homoeopathy

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6c Potency Of Terminalia Chebula Reveals Secondary Metabolites And Induces Apoptosis In Triple-Negative Breast Cancer Cells (Tnbcs), Apoorva Parimoo, Shama Aphale, Prajakta D. Patil, Ruchika Kaul Ghanekar Dec 2025

6c Potency Of Terminalia Chebula Reveals Secondary Metabolites And Induces Apoptosis In Triple-Negative Breast Cancer Cells (Tnbcs), Apoorva Parimoo, Shama Aphale, Prajakta D. Patil, Ruchika Kaul Ghanekar

Indian Journal of Research in Homoeopathy

Background: Breast cancer is a prevalent malignancy in women globally, and TNBCs, being ER-/PR-/Her2-, pose challenges in treatment options. Complementary and alternative medicines, including homoeopathic remedies, have gained popularity as potential anti-cancer agents to mitigate the side e ects of conventional drugs. Previously, the anticancer activity of homoeopathic potencies of Terminalia chebula (MT, 3X, 6C, and 30C) against breast cancer cell lines has been reported. Objectives: This study aimed to evaluate the mechanism of anticancer activity of 6C potency of T. chebula against the TNBC cell line, MDAMB231 and to understand the phytochemical composition of 6C potency. Methods: …