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Articles 1081 - 1110 of 88451
Full-Text Articles in Entire DC Network
Association Of Abo Blood Groups With Dengue Fever And Its Severity: A Study In Surabaya, Indonesia, Sulistiawati Sulistiawati, Linda Dewanti, Ronald Pratama Adiwinoto, Raissa Manika Purwaningtias, Bilqis Inayatillah, Jan Nouwen
Association Of Abo Blood Groups With Dengue Fever And Its Severity: A Study In Surabaya, Indonesia, Sulistiawati Sulistiawati, Linda Dewanti, Ronald Pratama Adiwinoto, Raissa Manika Purwaningtias, Bilqis Inayatillah, Jan Nouwen
Journal of Health Research
Background: Indonesia, a dengue-endemic country, has high morbidity and mortality rates. Dengue infection manifestations vary from asymptomatic to mild to severe. One of the risk factors for infection that plays a role in this severity is blood type. A better understanding of the risk factors for dengue infection is required to prevent and control it.
Methods: This analytical observational cross-sectional study was conducted at three hospitals in Surabaya from March to May 2013. Consecutive sampling included 95 patients aged >12 years with confirmed dengue infection (IgM/IgG positive) and without comorbid severe illness. Data were collected using questionnaires, interviews, and checklists, …
Artificial Intelligence Powered System For Dynamic And Personalized Interactive Learning From Video Content, Prameela Kavya Thummuru, Aravind Reddy Ayuluri
Artificial Intelligence Powered System For Dynamic And Personalized Interactive Learning From Video Content, Prameela Kavya Thummuru, Aravind Reddy Ayuluri
Defensive Publications Series
Educational video content may result in passive consumption and suboptimal knowledge retention by viewers of the video content who most often are children. Existing interactive viewing solutions may be limited by pre-scripted questions, a lack of personalization for individual or multiple viewers, and/or an inability to adapt content across viewing sessions. Described herein is the use of an artificial intelligence (AI) model to enhance video-based learning. The AI model analyzes video transcripts to intelligently identify optimal moments in the video content for interaction with the video based on pedagogical principles and viewer profiles. Breakpoints are inserted in the video content …
Mental Health First Aid Certification's Impact On Filipino Nurses' Ability To Increase Personal Help-Seeking Behaviors, Self-Awareness Of Health Changes, And Improved Self-Connection, Maria Elena Holguin, Brenda Marshall, Faith Atte, Katherine J. Roberts
Mental Health First Aid Certification's Impact On Filipino Nurses' Ability To Increase Personal Help-Seeking Behaviors, Self-Awareness Of Health Changes, And Improved Self-Connection, Maria Elena Holguin, Brenda Marshall, Faith Atte, Katherine J. Roberts
School of Nursing Faculty Scholarship and Creative Works
Background
Post COVID-19, almost 50% of nurses reported severe depression, and over 30% moderate to severe anxiety. Nurses from minority racial and ethnic backgrounds, including Filipino nurses, accounted for more than 54% of COVID-related deaths, despite comprising only 24.1% of the nursing workforce. Filipino nurses, making up only 1% of the U.S. population, comprise 4.5 % of the nursing workforce and face significant barriers to seeking mental health services, including stigma, a sense of shame, and adherence to cultural values that view mental illness as unacceptable.
Aim
To assess the impact of Mental Health First Aid (MHFA) certification among Filipino …
Absolute Extraction: Utilizing Rural Critical Criminology To Examine Appalachia’S Toxic Dependence On Extractive Industries, Andrew Kennedy
Absolute Extraction: Utilizing Rural Critical Criminology To Examine Appalachia’S Toxic Dependence On Extractive Industries, Andrew Kennedy
The Mid-Southern Journal of Criminal Justice
Brought forth by common rhetoric, Appalachia is often viewed as the closest space to that of an empyrean domain. Separated from the sleepless city, its allure rests in its created identity of a quiet, green escape from the city, which offers serenity on all fronts. Although Appalachia can fulfill this profile, such an ascension ignores the burning yellow grass below. The purpose of this paper is to examine the history of the destruction of Appalachia through the lens of extractive industries and the region’s designation as a sacrifice zone. Through the application of rural critical criminology, this paper holds that …
Welcome From The Editors: Criminal Justice Systems Helping Communities: Provision Of Resources And Experience For Positive Change, Cassandra B. Whyte Dr., Stephen Young
Welcome From The Editors: Criminal Justice Systems Helping Communities: Provision Of Resources And Experience For Positive Change, Cassandra B. Whyte Dr., Stephen Young
The Mid-Southern Journal of Criminal Justice
No abstract provided.
Reducing Rates Of Child Abuse And Neglect: An Analysis Of Three Potential Solutions, Lauren C. Heil
Reducing Rates Of Child Abuse And Neglect: An Analysis Of Three Potential Solutions, Lauren C. Heil
The Mid-Southern Journal of Criminal Justice
Child abuse and neglect are prevalent problems, affecting an estimated one million children worldwide each year. The purpose of this paper is to evaluate and analyze three potential solutions to reduce the rates of child abuse and neglect. The three programs that were suggested were: improving overall access to healthcare, therapy and counseling, and other support services for children and families who need them, implementing more Nurse-Family Partnerships across the United States for first time mothers with visits from a registered nurse, and increasing parent’s access to economic resources and improving families overall financial security. These programs were researched extensively, …
The Controlled Substances Act: A Menagerie Of Arbitrary Regulation And Failure Of Purpose, Dylan Andrus
The Controlled Substances Act: A Menagerie Of Arbitrary Regulation And Failure Of Purpose, Dylan Andrus
The Mid-Southern Journal of Criminal Justice
The Controlled Substances Act (CSA) is the primary regulatory and criminal legislation surrounding drugs in the United States. Passed in the 1970s, the CSA established the drug classification scheduling system we use today. Despite being over 50 years old today, the CSA has not achieved its goal of eliminating or even significantly reducing drug use and offenses. This paper conducts an analysis of the CSA's legislative intent versus its actual results through reviews of measures such as incarceration rates, inconsistent regulation, and disproportionate racial effects to argue that the Controlled Substances Act has failed in its mission while causing significant …
Bridging The Gap Between Substance Use Treatment Barriers In Rural Areas, Dakota Baker
Bridging The Gap Between Substance Use Treatment Barriers In Rural Areas, Dakota Baker
The Mid-Southern Journal of Criminal Justice
The purpose of this paper is to examine the continued concern about substance abuse/misuse and limited access to treatment in rural areas. Rural areas lack the adequate treatment needed to combat substance use disorder (SUD), mainly due to the lack of sufficient providers trained to identify, treat, and support those dealing with SUD. Additional barriers such as the high cost of treatment, stigma surrounding substance use disorders, geographical barriers, and the criminalization of substance abuse are other barriers that will be discussed in this paper (Griffin & Botvin, 2010; Hargons et al., 2023; Khazaee-Pool et al., 2024; National Center for …
Lost In Translation: How Health Literacy Impacts Pharmaceutical Transactions From Healthcare Professionals To Patients, Grace Nwaege
Lost In Translation: How Health Literacy Impacts Pharmaceutical Transactions From Healthcare Professionals To Patients, Grace Nwaege
2025 Fall Honors Capstones Projects - Archive
Health literacy is a core element of public health, involving the ability to access, understand, evaluate, and use information to maintain well-being. In the United States, it aligns with an average reading level of about an eighth grader, which continues to decline over time. As pharmacists serve as the final point of contact in most outpatient settings, their ability to communicate effectively at this literacy level is crucial. This study examines how pharmacies address this challenge using qualitative methods, including health literacy assessments of patient consent forms and stakeholder interviews with pharmacy technicians about resource use. Findings show materials higher …
Teachers' Perspectives On Humane Education Implementation, Rebecca Ann Bartaway
Teachers' Perspectives On Humane Education Implementation, Rebecca Ann Bartaway
Walden Dissertations and Doctoral Studies
Humane education (HE) encompasses multiple concepts, including animal ethics, ecological environment, and social justice. The problem prompting this study was that individuals who have graduated from a higher education HE program face challenges in successfully integrating HE into their K–12 classrooms. Grounded by Weil's solutionary approach to HE, the purpose of this basic qualitative study was to explore the teaching experiences of individuals who graduated from a higher education HE program and successfully integrated HE into their classrooms. Participants were purposefully sampled from a small population of educators who completed a U.S. degree or certificate program in HE and successfully …
Leadership Strategies For Capturing And Transferring The Knowledge Of Experienced Workers In Canadian Higher Education Organizations, Dean Allan Bulloch
Leadership Strategies For Capturing And Transferring The Knowledge Of Experienced Workers In Canadian Higher Education Organizations, Dean Allan Bulloch
Walden Dissertations and Doctoral Studies
Higher education institutions face a risk of knowledge loss when they fail to implement strategies for transferring knowledge from experienced to less experienced employees. Canadian higher education managers are particularly concerned about the adverse impact of losing explicit and valuable tacit knowledge. Grounded in the socialization, externalization, combination, and internalization model, this qualitative pragmatic inquiry study identified and explored successful strategies employed by eight Canadian higher education managers to capture and transfer knowledge from experienced employees, thereby sustaining performance. Data were collected through semistructured interviews and a review of public documents, including strategic plans, annual reports, and accountability statements. Through …
Intersectionality, Epistemic Injustice, And Silencing: The Operationalization And Reification Of Intersectionality In Academic Research And Institutional Practices, Emery Lockwood
Theses - ALL
Intersectionality is a powerful analytic tool that can be used to better understand the role that oppression plays in society and how it shapes the way people affected by multiple systems of oppression interact with society. Recently, the unit of analysis for intersectionality has started to shift from intersecting systems of oppression to overlapping identities, which has changed intersectionality from being a tool used to analyze systemic oppression to individual’s experiences. This work explores the implications this shift has on academic research and the practice of several disciplines. Using a lens of epistemic injustice through theories of hermeneutical bastardization (Drury, …
Longitudinal Association Between Sleep Disturbance And Disordered Eating In Adolescents: The Mediating Role Of Emotion Dysregulation, Antonia Louise Hamilton
Longitudinal Association Between Sleep Disturbance And Disordered Eating In Adolescents: The Mediating Role Of Emotion Dysregulation, Antonia Louise Hamilton
Theses - ALL
Accruing evidence suggests a significant relationship between sleep disturbances and disordered eating. Early adolescence is a period of heightened vulnerability for sleep disturbances and disordered eating. However, the longitudinal relationship between sleep disturbance and disordered eating remains unclear in early adolescent samples. The current study aims to examine if sleep disturbance longitudinally predicts disordered eating in early adolescents three years later, how the odds of having clinically significant disordered eating change per each unit increase in sleep disturbance, and if emotion dysregulation mediates these relationships. It is hypothesized that baseline sleep disturbance will predict greater disordered eating at follow-up, and …
Novel Origin Of Sperm Heteromorphism In The Drosophilidae, Karan Bhatt
Novel Origin Of Sperm Heteromorphism In The Drosophilidae, Karan Bhatt
Theses - ALL
Sperm heteromorphism, the production of two or more discrete sperm types or morphs within a single testis, occurs in diverse taxa. This phenomenon is believed to represent a division of labor by male gametes, with only one morph (the "eusperm") participating in fertilization and the other morph(s) specialized to perform some other (typically unknown) function within the female reproductive tract. One of the most intensively investigated systems is the Drosophila obscura species group, for which sperm heteromorphism evolved once in the common ancestor to the group, with all examined descendent species exhibiting sperm length heteromorphism. The absence of additional sperm …
Investigating The "Tend-And-Befriend" Stress Response As A Risk Factor For Sexual Victimization Among College Women, Emily Kathleen Presutti
Investigating The "Tend-And-Befriend" Stress Response As A Risk Factor For Sexual Victimization Among College Women, Emily Kathleen Presutti
Theses - ALL
Sexual victimization of college women is a significant public health concern on U.S. college campuses. Traditional research on the human stress response has focused on the "fight-or-flight" model, which may not adequately capture female-typical responses in stress-inducing situations. Using a mixed-methods design, we sought to determine whether the "tend-and-befriend" stress response serves as a potential correlate of sexual victimization among college women and examine whether it contributes additional variance beyond established correlates of sexual victimization such as alcohol use, history of sexual victimization, and involvement in campus party culture. The study was conducted in two phases. In Phase I, 128 …
Comparing The Antibacterial Efficiency Of Chitosan And Dextran As Nanocomposites Against Escherichia Coli, Saja Sachit, Alaa Al-Taie
Comparing The Antibacterial Efficiency Of Chitosan And Dextran As Nanocomposites Against Escherichia Coli, Saja Sachit, Alaa Al-Taie
Baghdad Science Journal
Nanoparticles (NPs) are widely used in many different fields and applications. In this study, Silver (Ag) NPs and Titanium dioxide (TiO2) NPs were generated using the laser ablation method by using Q-switched Nd: YAG laser. In addition, Chitosan (CS) and Dextran nanopolymers were chosen to prepare the nanocomposites by combining the two types of nanopolymers with the generated NPs in different ratios to obtain the samples: CS and Dextran as a control, CS-Ag, CS-TiO2, CS Ag-TiO2, Dextran-Ag, Dextran-TiO2, and Dextran Ag-TiO2. Several tests were carried out on these nanocomposites such …
Biosynthesis Of Silver Nanoparticles From Halophilic Green Algae (Dunaliella Viridis) Extract And It Is Antibacterial Activity, Payman Omer Salih, Trifa Kamal Jalal, Hoshyar Abdullah Azeez
Biosynthesis Of Silver Nanoparticles From Halophilic Green Algae (Dunaliella Viridis) Extract And It Is Antibacterial Activity, Payman Omer Salih, Trifa Kamal Jalal, Hoshyar Abdullah Azeez
Baghdad Science Journal
Biological synthesis of nanoparticles is a new area of nanotechnology that has advantages in terms of cost and the environment compared to chemical or physical synthesis methods. The current work is carried out to synthesize silver nanoparticles (AgNPs) utilizing green algae (Dunaliella viridis Teodoresco 1905) extract as a reducing and capping agent and to evaluate the antibacterial efficacy of AgNPs. The. The measures of UV-V spectroscopy, XRD, TEM, SEM-EDSand FTIR were used to characterize the synthesized silver nanoparticles. Additionally, agar well diffusion and minimum inhibitory concentration (MIC) methods were used for antibacterial activity. The plasmon absorbance of AgNPs was …
Policies Of Pain: Neoliberal Rhetorics Of The Opioid Epidemic In Culture And Policy, Gina Arlene Stinnett
Policies Of Pain: Neoliberal Rhetorics Of The Opioid Epidemic In Culture And Policy, Gina Arlene Stinnett
Dissertations - ALL
This dissertation outlines and examines the Neoliberal rhetorics of choice and responsibility, and how these rhetorics are utilized in policy and culture related to the Opioid Epidemic in the United States. Through this examination of neoliberal rhetorics in policy and culture, I unpack the circular influence these two have on each other—i.e., cultural assumptions inform policy decisions, and established policy can slowly influence cultural assumptions. The key area in which these two influence each other is through rhetoric, therefore I argue that in addition to an economic and cultural structure, neoliberalism is a rhetorical structure—it shapes our society specifically through …
The Aurora Survey: Robust Helium Abundances At High Redshift Reveal A Subpopulation Of Helium-Enhanced Galaxies In The Early Universe, Danielle A. Berg, Ryan L. Sanders, Alice E. Shapley, Michael W. Topping, Naveen A. Reddy, Evan D. Skillman, Erik Aver, Fergus Cullen, Callum T. Donnan, James S. Dunlop, Tucker Jones, Ali Ahmad Khostovan, Derek J. Mcleod, Desika Narayanan, Pascal A. Oesch, Anthony J. Pahl, Max Pettini, N. M. Förster Schreiber, Daniel P. Stark
The Aurora Survey: Robust Helium Abundances At High Redshift Reveal A Subpopulation Of Helium-Enhanced Galaxies In The Early Universe, Danielle A. Berg, Ryan L. Sanders, Alice E. Shapley, Michael W. Topping, Naveen A. Reddy, Evan D. Skillman, Erik Aver, Fergus Cullen, Callum T. Donnan, James S. Dunlop, Tucker Jones, Ali Ahmad Khostovan, Derek J. Mcleod, Desika Narayanan, Pascal A. Oesch, Anthony J. Pahl, Max Pettini, N. M. Förster Schreiber, Daniel P. Stark
Physics Faculty Scholarship
We present the first robust helium (He) abundance measurements in star-forming galaxies at redshifts 1.6 ≲ z ≲ 3.3 using deep, moderate-resolution JWST/NIRSpec spectroscopy from the AURORA survey. We establish a high-z He sample consisting of 20 galaxies with multiple high-signal-to-noise-ratio (>5σ) He i emission-line detections, including the critical near-infrared λ10833 line. This is the first study at high redshift leveraging λ10833 to break degeneracies between temperature, electron density, optical depth, and He+/H+, enabling reliable He abundance determinations in the early Universe. We use a custom Markov Chain Monte Carlo framework incorporating direct-method electron …
Surgical Treatment Of Post-Traumatic Elbow Stiffness In Pediatric Patients: A Systematic Review And Meta-Analysis, Roya Khorram, Areeb Ahmad, Reza Vafadar, Ronald Joseph Shamus, Surena Namdari, G. Russell Huffman, Amir R. Kachooei
Surgical Treatment Of Post-Traumatic Elbow Stiffness In Pediatric Patients: A Systematic Review And Meta-Analysis, Roya Khorram, Areeb Ahmad, Reza Vafadar, Ronald Joseph Shamus, Surena Namdari, G. Russell Huffman, Amir R. Kachooei
Rothman Institute Papers
BACKGROUND: Post-traumatic elbow stiffness (PTES) has been reported in up to 21% of pediatric patients following elbow fractures and can profoundly compromise a child's function, and independence. The primary surgical approaches include open and arthroscopic arthrolysis, both of which have demonstrated improvements in range of motion (ROM) and functional scores. This systematic review and meta-analysis aims to compare the effectiveness, ROM, and complication rates between open and arthroscopic release in pediatric patients with PTES.
METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were utilized to conduct a systematic review and meta-analysis on surgical treatment for PTES. Comprehensive …
Espacios De Cambio: Evaluating Community-Based Art Therapy Within The Latinx Community, Bennie Guzman
Espacios De Cambio: Evaluating Community-Based Art Therapy Within The Latinx Community, Bennie Guzman
Theses - ALL
This research presented in this graduate thesis explores the social-emotional benefits of community-based approaches of art therapy within the Latinx community. The literature contextualizes the socio-historical experiences of the Latinx community and presents an argument for the use of a community-based approach of art therapy. This study evaluates the social-emotional benefits of the “Arts as Mindfulness” program, an initiative created by the author in collaboration with La Casita Cultural Center at Syracuse University. Methods of data collection include creative reflections and a focus group with program participants. The research conducted data analysis using a hermeneutic phenomenological approach. Themes that arose …
Assessing The Gender Differences In Mental Health Access And The Intersectionality Of Depression, Anxiety, Stress Between Black Men And Black Women During Covid-19, Turquoise Ef'e Pipes
Assessing The Gender Differences In Mental Health Access And The Intersectionality Of Depression, Anxiety, Stress Between Black Men And Black Women During Covid-19, Turquoise Ef'e Pipes
Walden Dissertations and Doctoral Studies
The COVID-19 pandemic, which emerged in the past five years, has had a particularly severe impact on well-being, mental health, and access to care for Black communities. Therefore, the purpose of this quantitative study, grounded in intersectionality theory was to assess gender differences between Black women and Black men confronted with depression, anxiety, stress symptoms and mental health access during the crisis of COVID-19, which has been under researched within this demographic. The study sample included participants from various cities across the United States who lived through the COVID-19 pandemic from March 2020 to March 2023 (n= 104). A MANOVA …
Virtually Present In The Vastness: Vr’S Pathway To Awe And Appreciation, David Paul Peters
Virtually Present In The Vastness: Vr’S Pathway To Awe And Appreciation, David Paul Peters
Dissertations - ALL
This dissertation explores how spatial presence in Virtual Reality (VR) creates awe and appreciation through the role of perceived vastness. 92 participants played a custom-built VR game (VR Nature Photographer) in three environments designed to be low, medium, and high in vastness. A repeated-measures design measured spatial presence, vastness, awe, and appreciation across conditions. Results showed higher vastness increased all four outcomes, with awe and vastness having the largest effect sizes and presence and appreciation medium sized. Mediation analyses showed perceived vastness fully mediated the effect of spatial presence on awe in all vastness conditions and partially mediated its effect …
Building Bridges: Industrial Trade Unions In A Changing Climate, Nicole Möller
Building Bridges: Industrial Trade Unions In A Changing Climate, Nicole Möller
Dissertations - ALL
This dissertation examines how German industrial trade unions and workers in the automobile and coal industries navigate the profound challenges of the green transition. Workers’ experiences are situated within a broader political-economic context shaped partly by market-led decarbonization efforts, welfare retrenchment/austerity, erosion of progressive institutions in society, and global competition, as well as a global restructuring of value accumulation. The analysis critically engages with unions’ current responses to a market-led transition and their implications for labor’s future. The dissertation develops its argument across three empirical chapters. Chapter 2 investigates workplace-level changes in coal mining and automobile production, analyzing how workers …
Effects Of Π-Rich Solvents And Nickel And Cobalt Dopants On The Synthesis And Properties Of Cesium Lead Halide Nanocrystals, Tsung-Hsing Chiang
Effects Of Π-Rich Solvents And Nickel And Cobalt Dopants On The Synthesis And Properties Of Cesium Lead Halide Nanocrystals, Tsung-Hsing Chiang
Dissertations - ALL
Colloidal semiconductor nanocrystals feature unique properties like quantum confinement, tunable band gaps, and high surface-to-volume ratio; and have been proven as prominent materials in applications such as light-emitting diodes, sensors, lasers, solar cells, etc. Optoelectronic properties of semiconductor nanocrystals are highly associated with their sizes, morphologies, and compositions. Understanding the growth mechanism can lead to the ability to control the size, morphology, and composition of nanocrystals. In this thesis, growth and b-site doping of perovskite, cesium lead halide (CsPbX3), nanocrystals are discussed. Solvent effects in the growth of cesium lead bromide were first investigated from the aspect of plumbates in …
Robust Security Assurance In Cyber-Physical Systems: From Attack Diagnosis To Attack Resilience, Zifan Wang
Robust Security Assurance In Cyber-Physical Systems: From Attack Diagnosis To Attack Resilience, Zifan Wang
Dissertations - ALL
Cyber-Physical Systems (CPS) have become integral to critical infrastructure, from autonomous vehicles to industrial control systems. However, their increased connectivity and sophistication introduce new vulnerabilities, making security a paramount concern. This dissertation presents a comprehensive pipeline for enhancing CPS security, focusing on accurate diagnosis of trustworthy time frames and subsystems, followed by system resilience measures to restore safe states. The foundation of system resilience lies in an advanced checkpointing protocol for real-time multi-process systems. A novel three-step approach uniquely addresses both logical and timing correctness, which are crucial for modern CPS applications. By partitioning processes into directed acyclic graphs, implementing …
Essays On Housing Choices, Neighborhood Quality, And Urban Blight, Samuel Saltmarsh
Essays On Housing Choices, Neighborhood Quality, And Urban Blight, Samuel Saltmarsh
Dissertations - ALL
This dissertation contains two chapters related to housing choices of low-income families, neighborhood quality, and the remediation of urban blight. The first chapter examines the effectiveness of Detroit's 2014–2022 residential demolition program in addressing neighborhood blight and vacancy in a shrinking city context. Using a stylized model of durable housing with downward price frictions, I combine parcel-level data on vacancies, blight, and demolitions to estimate the causal effects of demolition exposure on vacancy rates for non-demolished, single-family homes. Employing a difference-in-differences design, I find that the program as a whole did not reduce vacancies, and instead slightly increased them by …
Feasibility Of Exercise And Mindfulness Intervention For Improving Psychological Symptoms In Female University Students With Smartphone Addiction: A Pilot Study, Huange Liu, Kim Geok Soh, Shamsulariffin Samsudin, Suriyan Somphong, Ranintya Meikahani, Nugroho Puji Santoso
Feasibility Of Exercise And Mindfulness Intervention For Improving Psychological Symptoms In Female University Students With Smartphone Addiction: A Pilot Study, Huange Liu, Kim Geok Soh, Shamsulariffin Samsudin, Suriyan Somphong, Ranintya Meikahani, Nugroho Puji Santoso
Modern Sport
The prevalent use of smartphones has raised significant concerns regarding smartphone addiction among university students. This addiction can lead to a range of psychological problems, which may ultimately affect their academic performance and overall well-being. Engaging in exercise has been linked to improved mental well-being, mainly by regulating endorphin levels, which can help reduce feelings of anxiety and depression. Mindfulness-based interventions (MBIs) have become effective strategies for tackling different psychological challenges. Evidence indicates that mindfulness practices can significantly decrease stress, anxiety, and depression levels. Combining exercise with mindfulness (EM) techniques can boost their overall effectiveness and provide additional mental health …
Exploring The Chemical And Biological Foundations Of Protein Lipidation Through Functional And Computational Studies, Andrea Sprague-Getsy
Exploring The Chemical And Biological Foundations Of Protein Lipidation Through Functional And Computational Studies, Andrea Sprague-Getsy
Dissertations - ALL
Post-translational modifications (PTMs) are essential for the diversification of the human proteome. Prenylation is a PTM defined by the addition of a 15-carbon or 20 carbon isoprenoid group by FTase and GGTase-I, respectively, onto a cysteine near the C-terminus of proteins. This modification is the first step within the prenylation pathway where proteolysis and carboxymethylation occur afterwards, aiding in proteins localization to the cellular membrane. These prenyltransferases canonically recognize a “CaaX” box motif which has been determined through biochemical and structural studies. Recently, sequences following the C(x)3X and Cxx patterns have been shown to be prenylated as well as an …
On Detecting Change-Points Of A Segmented Logistic Regression Model, Jingwen Li
On Detecting Change-Points Of A Segmented Logistic Regression Model, Jingwen Li
Dissertations - ALL
This dissertation investigates the problem of change-point detection in segmented logistic regression models, where the total number of change-points is unknown. We consider both unconstrained models, which allow discontinuities at change-points, and constrained models, which impose continuity across change-points. The central challenge is to determine the number of change-points and to accurately estimate their locations, while ensuring valid statistical inference for the associated regression coefficients. We begin by introducing a set of regularity assumptions that underlie the theoretical analysis throughout this work. For a given number of change-points, we present algorithms to estimate their locations and obtain the maximum likelihood …