Digital Commons Network^™

Evaluating Diagnostic And Treatment Timelines For Alk-Positive Nsclc Patients: Results From A Global Registry For Consideration In The Journal Of Clinical Lung Cancer, Swara Chindhade, Aula Alqased

Undergraduate Student Symposium

ALK-positive non-small cell lung cancer (NSCLC) is an aggressive subtype affecting younger, nonsmoking individuals. Tyrosine kinase inhibitors (TKIs) are essential treatments; however, global data on comorbidities, diagnosis, treatment, and intervals from initial medical visits to TKI treatment remain limited. This study examines symptoms, comorbidities, and treatment timelines to identify factors contributing to delays in TKI treatment. We conducted a longitudinal observational study using a global registry of ALK-positive NSCLC patients via online surveys from September 2022 to November 2024. Participants were recruited through support groups, patient newsletters, and oncologist referrals. Descriptive statistics and multivariable regression analyses evaluated the impact of …

Examining The Impact Of Volleyball-Specific Movements On Landing Using Vert Wearable Technology, Camille Fonseca

Undergraduate Student Symposium

The sport of volleyball involves constant vertical and lateral motion, as it requires players to attack, block, or serve a ball. The frequency of jumps and landings creates stress on the body, predisposing female athletes to lower extremity injuries. Additionally, volleyball-specific movements such as the slide, swing block, and 7-ball, may cause injury. The purpose of this study is to assess jumps and landings from volleyball-specific movements in female collegiate volleyball athletes using VERT wearable technology. National Collegiate Athletic Association Division II Volleyball athletes wore the VERT device collecting data on performance and workload during team practices and games including …

Exploring Dual-Language Testing And Verbal Ability Performance In Non-Native English Speakers, Jaylyn Marte, Andrea Fajardo Aguilar

Undergraduate Student Symposium

Research suggests that Spanish/English bilinguals do not perform as well as English-speaking monolinguals on tests of verbal ability. Even when born, raised, and educated in the US, Spanish/English bilinguals do not perform as well as monolinguals. The current study was designed to investigate whether: (1) Spanish/English bilingual college students improve their performance on verbal ability tests when given the opportunity to respond in either of their two languages relative to responding only in English; and (2) do they perform similar to monolinguals under dual language testing. A previous study from our laboratory used the Bilingual Verbal Ability Test (BVAT) which …

Exploring Oral Health Challenges In Pateints With Als: Practices, Barriers, And Disparities, Eden Pressley

Undergraduate Student Symposium

Proper oral health is often neglected in vulnerable populations such as persons living with ALS (plwALS) due to the myriad of physical demands and limitations of the disease.¹ Poor oral hygiene increases the risk of aspiration pneumonia, with studies demonstrating oral bacteria in the pulmonary tract of patients with pneumonia, and contributes to oral discomfort, reduced quality of life and increased caregiver burden.^4-6 Although oral hygiene represents a modifiable risk factor for pulmonary sequalae, it is not routinely addressed in the current standard of care for ALS and our knowledge of oral health in plwALS is limited. Therefore, …

Growth And Survival Of Sexually Propagated Land-Reared Brain Corals During An Intermediate Offshore Nursery Phase, Emma Horton

Undergraduate Student Symposium

Florida’s Coral Reef has degraded from significant stony coral loss due to global and local stressors, including heat stress, disease, and coastal development, leading to reduced natural coral recruitment. Assisted sexual propagation in land-based nurseries can increase the number of genetically unique corals available for restoration efforts. A grow-out phase, in which land-reared corals are placed into an offshore nursery before outplanting on the reef, is often employed to allow corals time to grow and acclimate to the ocean environment. However, research on the performance of recruits within offshore nursery settings remains limited. Here we examine the growth and survival …

Identifying Key Characteristics In Aspiring Healthcare Professionals: A Strengths And Preference Profile Analysis On Emotional Intelligence, Abbygail Salcido, Emily Young

Undergraduate Student Symposium

Topic: As undergraduate students in a pre-health path or an advisor for these students, understanding one's priorities, strengths, and motivations is crucial for self-awareness and career clarity. This understanding is pivotal in guiding students toward a fulfilling and appropriate career choice. Purpose: Our study aims to identify the characteristics of students with the potential to excel as Optometrists - a profession known for its emphasis on patient care, attention to detail, and creative intuition. In our current investigation, we assessed 125 students aspiring to become Optometrists. Each participant completed a strengths inventory and a positive psychology-based personal preference test. According …

Impact Of Hnrnp1/2 Modulation (Or Downregulation) On Alternative Exon Splicing In Wm266-4 Melanoma Cells, Chloe Brooks-Noriega

Undergraduate Student Symposium

This study aims to conduct an unbiased analysis of the modulation of heterogeneous nuclear ribonucleoproteins H1 and H2 (hnRNPH1/H2) on overall melanoma RNA expression in vitro. At present it is estimated that approximately 57,000 melanoma deaths occur worldwide each year. This prevalence, in conjunction with melanoma molecular heterogeneity and resulting difficulty in treatment, means that there is always a need for new treatment methods. A compound discovered in the lab, named 2155-14, has demonstrated selectivity in targeting melanoma cells by binding to hnRNPH1 and hnRNPH2, two closely related proteins that participate in RNA splicing. We performed Illumina RNA sequencing …

Improving Enzyme Activity And Stability Using Polymer Grafting, Chris Cherian, Victor Lu, Chanakya Prasad Valmiki, Stebin Chanasseril

Undergraduate Student Symposium

Enzymes are ideal chemical catalysts because of their selectivity and specificity. However, the use of enzymes in synthesizing new products is limited by their activity loss due to protein denaturation in a reaction mixture. The purpose of this study is to stabilize model enzymes by attaching them to polymers. Asparaginase, glucose-6-phosphate dehydrogenase and b-galactosidase are chosen for this study. These enzymes are selected because of their important functions in cancer treatment, measuring glucose levels in clinical samples, or making lactose-free dairy products. The free amine groups of N-terminus and lysine residues were chemically modified to attach these enzymes to the …

Income Disparities In Educational Institutions And The Risk Of Prediabetes In Students, Dev J. Patel, Saketh Kodavanti, Toby Cheng

Undergraduate Student Symposium

Approximately thirty-five million Americans face type 2 Diabetes: a chronic health condition that results in complications like heart disease, kidney failure, and more. Most students ages 6 to 18 spend most of their time in schools, making the funding of these institutions a major factor in their health. Identifying type 2 diabetes, defined as a blood sugar greater than 126 mg/dL, is an early biomarker of type 2 diabetes, enabling early intervention. The research question is "What is the relationship between socioeconomic inequalities in education institutions and the prevalence of type 2 diabetes amongst 6-18-year-olds?"

A descriptive systematic review of …

Investigating The Role Of Dnmt Inhibitor Cm-272 Through P21-Mediated Apoptosis In Sk-N-Sh Neuroblastoma Cells, Sruthika Talanki, Sneha Subhash

Undergraduate Student Symposium

Neuroblastoma is a pediatric malignancy originating from neural crest cells, which can manifest the disease anywhere along the sympathetic nervous system. Evidence suggests that epigenetic modifications may trigger cell cycle arrest and induce apoptosis, providing a potential therapeutic avenue for such cancers.

This study investigates whether CM-272, a DNMT-1 inhibitor, promotes histone acetylation and upregulates p21 through a p53-independent pathway, ultimately triggering cell cycle arrest and apoptosis cell death via caspase-mediated mechanisms in SK-N-SH cells. To assess the effects of CM272, we conducted qRT-PCR to evaluate the DNMT-1 gene expression levels and performed western blot analyses to examine key proteins, …

Investigating The Structural And Functional Roles Of Transcriptionally Active Rice Transposons, Eimaan Ahmad, Leelakrishna Angadala, Udhay Nallapati, Rushil Mehrotra, Braham Dhillon Ph.D.

Undergraduate Student Symposium

Transposable elements (TES) are notorious given their contributions to genome dynamics, evolution, gene structure, and regulation of gene expression. Famously once branded as 'junk DNA', TEs are now known to play significant roles in genome structure and function. Plethora of data generated from sequencing projects have advanced the study of transposons but their large size-often larger than read lengths of most sequencing platforms- has limited TE research due to limited coverages in sequenced datasets. Additionally, high copy number of TEs and high sequence similarity-often greater than 80%- between multiple copies of a TE family may lead to erroneous and misguided …

Metformin's Beneficial Usage As A Therapeutic And Cost-Effective Drug For Ovarian Cancer, Kaitlin Chao, Leelakrishna Angadala

Undergraduate Student Symposium

According to the American Cancer Society, ovarian cancer is a leading cause of gynecologic cancer related mortality in the United States, with over 20,000 new cases and 14,000 deaths annually. Despite advancements in treatment, the need for effective, accessible, and affordable therapies remains critical. Metformin, a widely prescribed drug for type 2 diabetes, has shown significant promise as a cost-effective adjunct in ovarian cancer therapy.

This literature review examines emerging evidence on metformin's anticancer properties, including its ability to inhibit ovarian cancer cell proliferation through AMPK activation, mTOR inhibition, and modulation of the tumor microenvironment. Epidemiological studies report improved survival …

Modeling The Binding Of Five Selective Serotonin Reuptake Inhibitors (Ssris) To The Human Serotonin Transporter (Hsert) To Allosteric And Central Binding Sites, Alessandra Alvarez Coke, Ivanna Mathew, Srika Saai Talanki

Undergraduate Student Symposium

Rates of depression are rising globally. A proposed physiological basis of depression is low levels of neurotransmitters, in particular serotonin. SSRIs are a form of medication that is used to treat depression disorders by inhibiting the reuptake of serotonin by Human Serotonin transporter (hSERT). Modeling the structure of hSERT allows for rational drug design, potentially improving the medications that are available to the public. The Protein Data Bank file of hSERT was retrieved (PDB ID: 5I6Z). Additional PDB files were utilized to analyze various SSRIs and their respective central and allosteric binding sites to determine the most critical portions required …

Parasites In Flight: Toxoplasma Gondii Genotypes In South Florida Birds, Ava Barrasso, Katherine Hirt, Kaitlin Whalen, Shree Diora, Adhiraj Katoch, Aansi Patel

Undergraduate Student Symposium

Toxoplasma gondii is a zoonotic parasite that significantly impacts human and wildlife health. Often associated with domestic cats, avian hosts also contribute to the parasite's persistence in global ecosystems. This research investigates the strain diversity of T. gondii found within South Florida birds. Florida is an avian biodiversity hotspot along two migratory flyways and therefore presents unique opportunities to detect novel and/or virulent genotypes that may present health risks to humans. These risks are increasing with environmental factors (e.g. urbanization and climate change) that facilitate pathogen transmission between feral and domesticated animals, and susceptible human populations. Our approach consists of …

Pecking At Protozoan Parasites: Pcr Diagnostics Of Toxoplasma Gondii In South Floridian Birds, Senia Bu, Donna Huynh, Sridevi Gundimeda, Samhita Doranala, Madeline Hsu, Valentina Cevallos

Undergraduate Student Symposium

Toxoplasma gondii is a protozoan parasite whose prevalence and transmission remain underexplored in wildlife, especially in birds. This is a crucial gap since birds can serve as pathogen reservoirs (facilitating transmission to humans and other animals) and because T. gondii’s prevalence in wildlife (e.g. birds) helps illuminate its environmental distribution. Thus, characterizing T. gondii in local avian communities can help us assess and mitigate risks to the health of humans, pets, agricultural animals, and endangered wildlife. This study investigates T. gondii prevalence in South Florida’s diverse avian species. We obtained tissue samples from >100 birds by dissecting carcasses provided …

Photodynamic Inactivation (Pdi) Of Microorganisms With Copper Meso-Pyridyl Porphyrin Isomers, Dylan Mavlyanov, Sanjana Sivaiah, Andrew Siedlecki, Rohan Reddy, Andersen Cheong

Undergraduate Student Symposium

Photodynamic Inactivation (PDI) is an antimicrobial approach, independent of antibiotic resistance, that targets pathogens utilizing light and photosensitizers in the presence of oxygen. The growing international concern for the rise in drug-resistant microorganisms has driven research to determine approaches that will keep microbes from developing further immunological adaptations. Photosensitizers are molecules activated by light that produce reactive oxygen species (ROS) lysing and causing cell death in structures of microbes and in diseased mammalian cells. The photosensitizers applied in this experiment are meso–Tetra(N–methyl–pyridyl)porphine tetrachloride isomers. Three variations of the nitrogen placement were used to understand the interactions with the bacterial cell …

Resources And Racial Identity: Differences In Women's Accumulation Of And Preference For Six Forms Of Capital, Alyssa J. Grant

Undergraduate Student Symposium

Across the world, resources are a necessity so individuals can lead a healthy and wealthy life. Research has found there are six forms of resources that can be measured (Starratt and Zambrano, 2022). However, we do not yet know the extent to which resources are related to cultures, traditions and customs and so, may differ among people with different racial and ethnic identities. This study investigated differences among accumulation of and preference for six forms of resources among women of different racial and ethnic identities. The participants included 248 women who self-reported racial and ethnic identity and completed an inventory …

Role Of Exosomes In Gulf War Illness, Chetana Movva, Lily Tehrani, Joshua Frank

Undergraduate Student Symposium

Gulf War Illness (GWI) is a multi-symptom chronic disorder affecting over 200,000 veterans deployed during the Gulf War from 1990-1991. GWI veterans deployed during the Persian Gulf War were exposed to multiple chemical warfare agents. Veterans with GWI experience chronic pain, fatigue, neurocognitive symptoms, gastrointestinal (GI) disturbances, etc. GWI-associated biomarkers have revealed a proinflammatory biomarker signature, a discovery that has recently led to research further exploring the inflammatory response within GWI patients.

Exosomes are small extracellular particles that range in diameter between 50-200 nm and have specific markers. Exosomes contain DNA, proteins, and RNA and carry this information from one …

Stalking The Forests And Swimming In The Oceans: Trophic Flexibility In Alaskan Coastal Grey Wolves, Mckenna Smith, Miranda Brohman, Gretchen Roffler, Dimitrios G. Giarikos Ph.D.

Undergraduate Student Symposium

Coastal grey wolves of Southeast Alaska (Canis lupus ligoni) are opportunistic apex predators endemic to their environments. Large terrestrial vertebrates such as deer and marine organisms such as salmon dominate their diet. Large terrestrial vertebrates such as deer and marine organisms such as salmon dominate their diet. In recent years, wolves from Gustavus have moved back and forth between the mainland coastal environment and Pleasant Island, a small island 10 kilometers offshore. Wolves initially foraged on the island deer but more recently, a group of wolves has remained full-time on the island to forage on a marine diet …

Student Perception Of Ai And Its Effect On Creativity, Jade Sanchez, Juman Hai

Undergraduate Student Symposium

With the rise of Artificial Intelligence, it is important to investigate its impact on how this will affect students. Our study aimed to see how generative artificial intelligence (AI) affects student creativity levels. We hypothesized that as students use of AI increases, their creativity levels decrease. We collected data from participants’ demographics, their scores on the Short Scale of the Creative Self, an AI usage survey, and the Alternative Use Task (AUT). The creativity survey had subscales for Creative Self-efficacy, Personal Identity, and Self-concept. We also created subscales for ethical and unethical AI usage. Our data showed that there was …

Telemedicine For Post-Stroke Rehabilitation Impact Patient Quality Of Life Compared To Traditional In-Person Therapy, Rani Mehta, Shreya Katapally

Undergraduate Student Symposium

Background: The World Health Organization (WHO) reports that stroke accounts for around 11% of all deaths globally. Stroke rehabilitation plays a crucial role in helping patients recover and regain lost function, offering the potential for improved quality of life after a stroke. Unfortunately, in-person therapy can be challenging to access due to lack of transportation, financial burden, and geographical barriers. Telemedicine offers an alternative solution, allowing patients to receive therapy at the convenience of their home.

Research Question: What are the differences in recovery outcomes over time between stroke patients receiving telemedicine-guided physical therapy and those receiving in-person physical therapy? …

The Development, Ethical Controversies, And Importance Of Xenotransplantation, Dakota Koenig

Undergraduate Student Symposium

Xenotransplantation, the use of animal organs in human patients, is one of the newest developments in allotransplantation (Chisholm-Burns, 2024). Due to genetic similarities, pig livers and hearts could be used in patients waiting for a transplant. While these organs seem like the perfect solution, the organs must still be genetically altered to be used in human patients. Scholars like Thom et al (2023) explain how specific genes must be added to or removed from the pig’s genome to make the organs suitable for human transplants. While the idea seems to be a positive way to shorten the list of those …

The Effects Of Turkesterone On Isometric Muscular Strength, Alyana Andal

Undergraduate Student Symposium

Introduction: The supplementation of Turkesterone, a phytoecdysteroid, has been suggested to have the anabolic capability to enhance muscular growth thereby increasing muscular strength. The purpose of this study was to investigate the effects of Turkesterone supplementation on the isometric muscular strength of active males and females after four weeks of daily dosage.

Methods: The sample of this randomized, double-blind, placebo-controlled trial consisted of thirty-one males (n=14) and females (n=17) who were physically active. Participants orally consumed 500 mg of turkesterone (Ajuga Extract) or a placebo (rice flour) daily for four weeks. The handgrip strength of each participant was measured (i.e., …

The Effects Of Turkesterone On Mood And Sexual Functioning, Alexandra Jimenez Gonzalez

Undergraduate Student Symposium

Introduction: Turkesterone, an ecdysteroid found in the ajuga turkestanica plant, is a naturally occurring compound used historically in Central Asia and India to treat a multitude of health conditions. Turkesterone may hold properties that could improve physical and mental performance. This study aimed to determine the impact of four-week Turkesterone supplementation on mood and sexual function.

Methods: This randomized study included 30 active participants (14 males, 16 females). The placebo group received rice flour; the treatment group received Turkesterone (500mg/day). The participants were instructed to take their respective supplements for 28 days without altering their daily activities, diet, or exercise …

The Effects Of Turkesterone On Sleep, Antonio Crisanti, Ava Lukowiak, Tobin Silver Ph.D.

Undergraduate Student Symposium

Introduction

Turkesterone is a naturally occurring compound found in the ajuga turkestanica plant, traditionally used in Central Asia and India for treating various ailments. It has been suggested that supplementation with turkesterone, a type of ecdysteroid, may also have properties that promote improvements in physical and mental performance. Thus, the purpose of this investigation was to determine if four weeks of Turkesterone (500 mg daily dose) supplementation affect sleep quality.

Methods

This randomized, double-blind, placebo-controlled trial aimed to investigate the effects of turkesterone supplementation on mood, sexual functioning, and sleep quality in 30 active individuals (14 males, 16 females). Participants …

The Effects Of Turkesterone Supplementation On Body Composition, Ava Lukowiak

Undergraduate Student Symposium

It has been proposed that turkesterone supplementation can cause an increase in muscle mass and overall improvements in body composition. Turkesterone is a phytoecdysteroid derived from plants such as common wheat (Triticum aestivum) and Vitex plants (sage and mint). The purpose of this study was to determine if turkesterone supplementation in healthy, active males and females can increase lean muscle mass. This randomized, double-blind, controlled trial consisted of thirty-one physically active males (n=14) and females (n=17). Muscle mass was determined pre-test and post-test using a dual-energy Xray absorptiometry machine (DEXA). The treatment group ingested 500 milligrams of turkesterone daily for …

The Impact Of Doula Support On Maternal Mental Health, Neonatal Outcomes, And Epidural Use: Correlation With Mental Health Inventory-5 And Apgar Scores, Katherine Dookhan, Eesha Ramisetti, Rosselyn Perez, Rhea Hede-Sakhardande

Undergraduate Student Symposium

Maternal and neonatal health disparities disproportionately affect Black and biracial women in underserved communities, with higher rates of mental health challenges and adverse neonatal outcomes. This longitudinal cohort study examines the impact of doula support on maternal mental health, neonatal outcomes, and epidural use during labor. Participants are recruited from the Urban League of Broward County and the Broward Healthy Start Coalition in Florida and divided into two groups: those receiving doula support from 16 weeks of pregnancy to one month postpartum and those receiving standard care. Outcomes are assessed using the Mental Health Inventory-5 (MHI-5) for maternal mental health, …

Training Alters Joint Power Distributions During Running In National Football League Draft Preparation Players, Jacob Haberer

Undergraduate Student Symposium

The aim of this study was to compare joint-specific contributions to total lower limb joint power during a speed run in American style football players before and after a 6-week National Football League (NFL) draft preparation camp. Fifty-two players performed one 5-second treadmill run at 5.5 – 6.5 m/s before and after camp. Speed was consistent between tests. Bilateral hip, knee, and ankle power generation (positive) and absorption (negative) were calculated from kinematics and kinetics using inverse dynamics. Negative total limb power decreased for both limbs, significantly for the left (Z = - 2.113, p = .035, r = …

Understanding The Healthcare Needs Of Lgbtq+ Adults In South Florida, Vir Patel, Emilee Tennen, Christina Bedley, Dhruv Edamadaka

Undergraduate Student Symposium

Adults over the age of 65 represent 18% of Broward County's population. Over 886,000 lesbian, gay, bisexual, transgender, or queer (LGBTQ+) individuals live in Florida, with 43,000 LGBTQ+ seniors residing in Miami-Dade, Broward, and Palm Beach Counties. Lifetime stigma, discrimination, and structural stressors impacting their social determinants of health (SDOH) engender negative long-term health outcomes, such as elevated rates of mental health and substance abuse issues, among LGBTQ+ adults. The purpose of this study is to assess the SDOH that affect LGBTQ+ adults in South Florida and their interests in community health events. 110 LGBTQ+ adults who attended either the …

Volleyball Serve Analysis Using A Wearable Electroencephalograph (Eeg) Device In Collegiate Athletes, Taylor Stockman

Undergraduate Student Symposium

The volleyball serve is a crucial skill within the sport. Service errors drastically change the momentum of the game, and understanding how to reduce these errors could create positive outcomes for players. The study will utilize the electroencephalograph (EEG) device to analyze brain activity and record the four types of brain waves: alpha, beta, theta, and delta. The added component of the self-report survey will aid in exploring individual differences of athlete’s connection between brain function and volleyball serves. The purpose of this study is to assess collegiate volleyball players brain function during volleyball serves using a wearable EEG. Participants …