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The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher

Theses and Dissertations

Metabolic-associated fatty liver disease (MAFLD) represents an increasing global health challenge, with cholesterol-associated steatohepatitis (CASH) emerging as a distinct pathological entity warranting investigation. While CASH demonstrates unique features compared to traditional triglyceride-driven steatohepatitis, its underlying molecular mechanisms remain poorly understood. This study investigates a novel regulatory axis involving DPPA2 Upstream Binding RNA (DUBR), miR-210-5p, and retinol saturase (RETSAT). 170 patient samples revealed progressive axis dysregulation in disease states, with RETSAT emerging as a highly accurate diagnostic marker (AUC=1.000). Using novel in vitro models of MASH and CASH, we demonstrated that miR-210-5p modulation significantly affects lipid accumulation and cellular phenotype, with …

Emotional Eating Behaviors And Parental Feeding Practices In Three-Year-Old Children And Their Association With Body Composition One Year Later, Keely Wright, Kenia Rivera, Elysia Poggi Davis

Undergraduate Theses, Capstones, and Recitals

Emotional eating – eating in response to negative emotions regardless of hunger – is an obesogenic trait that often develops in childhood and remains a habit through adulthood. Greater emotional eating is associated with a higher body mass index (BMI; kg/m2) in 7-12-year-old children (Webber et al., 2009). However, few studies have examined the relations between emotional eating and weight gain in preschool-aged children. Moreover, there is limited research on parental feeding practices and weight gain in preschool-aged children. The current work investigated the association of emotional eating behaviors during an emotional eating task in three-year-old children with change in …

Intrapersonal And Interpersonal Factors Of Participation In Physical Activity And Resistance Training In Adolescent Girls: A Narrative Review, Ben Banse-Fay

University Honors Theses

Low rates of participation in physical activity and resistance training among adolescent girls are a concern due to increased health and injury risks. Adolescent girls participate in physical activity and resistance training at a lower rate than boys, which may explain higher rates of injury. Research examining physical activity of adolescent girls often utilizes an ecological framework, identifying intrapersonal, interpersonal, and environmental factors. Of these ecological levels, intrapersonal and interpersonal factors are modifiable without large costs.

Therefore, this review aimed to identify and summarize recent research that explores the intrapersonal and interpersonal factors associated with participation in physical activity and …

Analyzing Human - Nonhuman Primate Conflict Mitigation Techniques In Mto Wa Mbu, Northern Tanzania, Lil Adams

Undergraduate Theses, Capstones, and Recitals

Human-wildlife conflict is a widespread challenge faced by those living in regular contact with wildlife that can have profound impacts on livelihood outcomes for humans, wildlife, and their shared environment (Barua et al., 2013; Blackie, 2023). Human – non-human primate conflict is particularly crucial due to primates’ high capacity to live among human populations (Chapman & Chapman, 1990; Alberts & Altmann, 2006; Reader et al., 2011; Sinha & Vijayakrishnan, 2017), and is currently on the rise due to increasing contact between human and non-human primates (Hockings, 2016; Uddin et al., 2020). To characterize and analyze techniques currently being used to …

K-Means Clustering Optimization Of Toddler Malnutrition Status Using Elbow Method, Femmi Widyawati, Ahmad Yahya Dawod, Heru Agus Santoso

Journal of Informatics and Web Engineering

The problem of nutritional status is still a major challenge in the health sector in developing countries, including Indonesia. Malnutrition in toddlers can have serious long-term impacts on children's growth and development, including increased risk of disease, impaired cognitive function, and low productivity in the future. To overcome this problem, an in-depth analysis is needed to determine the distribution of nutritional status of toddlers in one of the provincial capitals in Indonesia, which can be used as a basis for planning more effective interventions. This study uses the K-Means algorithm to classify areas based on the prevalence of malnutrition in …

Editorial: Augmented Intelligence For Enabling Knowledge-Driven Decision Making, Heru Agus Santoso

Journal of Informatics and Web Engineering

More flexible and cooperative decision-making processes are required as a result of society's digital transformation. The role of augmented intelligence, that is the synergistic fusion of artificial intelligence and human judgment in facilitating knowledge-driven strategies across various domains is examined in this thematic issue. The integration of business intelligence and software engineering, which forms the foundation for creating intelligent, scalable, and explicable systems, is essential to this investigation. The six chosen papers in this issue show how machine learning techniques can be used to mine and model both structured (such as health records indicators) and unstructured (such as product reviews, …

Generative Ai-Based Meal Recommender System, Zheng Bin Ter, Palanichamy Naveen, J. Jayapradha

Journal of Informatics and Web Engineering

Maintaining a balanced diet is essential for overall well-being, yet many individuals face challenges in meal planning due to time constraints, limited nutritional knowledge, and difficulty aligning meals with personal dietary needs. Traditional meal recommender systems often rely on predefined plans or collaborative filtering techniques, limiting their adaptability and personalization. This study presents a generative AI-based Meal Recommender System utilizing Variational Autoencoders (VAEs) to generate personalized and nutritionally balanced meal plans. The system processes user inputs, such as dietary preferences, nutritional goals, and ingredient availability, to provide tailored recommendations. VAEs effectively uncover hidden dietary patterns and nutritional relationships within complex …

Bargaining And Ballplayers: The Practical Implications Of Minor League Baseball's Cba And What It Means For The Ncaa, Bobby Bramhall

Florida Entertainment and Sports Law Review

A commentary on the work place struggles of MiLB and how Collective Bargaining Agreement changed that. With this change how will it affect another athletic league, like the NCAA.

Evaluating The Cost-Effectiveness Of Atezolizumab-Bevacizumab In Advanced Hepatocellular Carcinoma: Insights From Taiwan, Tsung-Wei Chang, Wei-Chiao Chang, Wan-Hsuan Chou, Wei-Pin Chang, Chun-Nan Kuo

Journal of Food and Drug Analysis

Following the observed significant improvements in overall survival and progression-free survival in clinical trials, the combination of atezolizumab and bevacizumab has been recommended as a first-line therapy for patients with unresectable hepatocellular carcinoma. Despite its clinical benefits, the high cost associated with this treatment poses a substantial challenge in routine practice in Taiwan. This study aims to assess the cost-effectiveness of atezolizumab plus bevacizumab in comparison to sorafenib monotherapy. This study utilized partitioned survival analysis and extrapolated survival over a 20-year horizon to conduct a cost-effectiveness analysis from the perspective of the National Health Insurance Administration. Efficacy and utility data …

Integrating Network Analysis And Experimental Validation To Reveal The Ferroptosis-Associated Mechanism Of Velvet Antler In The Treatment Of Chronic Atrophic Gastritis, Quan Liao, Zhenzhen Guo, Chenchun Ding, Renjie Zuo, Guoyan Liu

Journal of Food and Drug Analysis

Chronic atrophic gastritis (CAG) is precancerosis with limited treatment options. This study investigated the therapeutic effects of velvet antler (VA), a traditional natural medicine, on CAG, with a focus on ferroptosis. In vivo experiments demonstrated the efficacy of VA in alleviating CAG, and network pharmacology analysis revealed its involvement in related terms, including inflammation, oxidative stress, and cell proliferation. Analyses further confirmed the modulation of ferroptosis by VA, particularly via the Keap1-Nrf2/HO-1/GPX4 pathway. In vitro assays supported these findings, demonstrating the ability of VA to reduce methylnitronitrosoguanidine-induced inflammation, oxidative stress, and ferroptosis in GES-1. This study provides a basis for …

Jiao San Xian Granule Containing Prebiotic Alleviate Functional Dyspepsia By Regulating Intestinal Flora And The Secretion Of Inflammatory Response, Huimin Pei, Mengyuan Zhao, Hongyue Wang, Xindi Zhang, Caihong Shi, Xiangrong Zhang

Journal of Food and Drug Analysis

Jiao Sanxian (JSX) consists of three traditional Chinese medicine including charred hawthorn, malt and Liu Shen Qu, they are also from Chinese medicine homologous food. It is commonly used to relieve functional dyspepsia (FD). The present study aims to explore the mechanism of JSX (granule), with the addition of prebiotics for the treatment of FD using mice model. The network pharmacology and molecular docking were used to forecast therapeutic targets for JSX. Based on the protein-protein interaction (PPI) results, thirteen targets exhibited strong interactions with each other. The results of network pharmacology and molecular docking revealed therapeutic activity of JSX …

Regulatory Framework And Challenges For Live Biotherapeutic Products In Taiwan, Shirley Pan, Jia-Chuan Hsu, Kuo-Teng Hung, Ching-Jung Ho

Journal of Food and Drug Analysis

Products containing live microorganisms may be classified as food or drugs depending on their intended use; live biotherapeutic products (LBPs) with therapeutic claims are defined as medicinal products containing live bacteria or yeasts intended to prevent or treat disease. Based on their characteristics, LBPs are classified as biological drugs and must be registered as biological drugs before they can enter the Taiwanese market. As research into the microbiota and its role in health and disease continues to advance, LBPs are expected to play an increasingly important role in medicine and biotechnology. With the growing popularity of microbial applications in recent …

Aspergillosis: A Comprehensive Review Of Pathogenesis, Drug Resistance, And Emerging Therapeutics, Amanpreet Singh, Jeewanjot Singh, Sandeep Kumar

Journal of Food and Drug Analysis

Aspergillosis stands as a primary opportunistic fungal infection which mainly results from Aspergillus fumigatus events that have gained more importance because of its multiple infection patterns and developing antifungal resistance. Healthcare providers identify two main ends of the aspergillosis spectrum which include allergic responses and invasive systemic infections that affect mainly immunocompromised subjects. This review presents a detailed summary for understanding the epidemiology of aspergillosis along with its risk factors as well as pathogenesis and host immune response and diagnostic difficulties. The analysis puts significant weight on increasing azole and echinocandin resistance that has become worse because of agricultural and …

Predictive Model For Hemoglobin Levels Using Multiple Linear Regression, Dien Gusta Anggraini Nursal, Muhammad Daffa Atthariq Winata, Nohan Arum Romadlona, Noura Rizki, Sabillah Nasitoh, Muhammad Sakhi Baretta

Journal of Health Research

Background: Anemia is a condition in which the number of red blood cells or hemoglobin (Hb) levels fall below normal, limiting the ability of blood to transport oxygen effectively. This study aimed to develop a predictive model for Hb levels by identifying significant risk factors.

Method: This observational analytic study was conducted among 103 randomly selected students of Bung Hatta University in Padang, Indonesia. Data were collected with a questionnaire and a hemoglobin test between April to May 2024. Pearson’s correlation analysis and multiple linear regression were performed in this study.

Results: Bivariate analysis showed significant correlations between Hb levels …

Relationships Between Perceptions And Breastfeeding Preparation Behaviors Among Mothers Of Preterm Infants Received Donor Human Milk, Roykrong Kheawlamyong, Jiraporn Punyoo, Tipawan Daramas

Journal of Health Research

Background: Donor human milk (DHM) is a vital nutritional alternative for preterm infants when mothers experience insufficient milk supply during the early postpartum period. However, supporting mothers in producing their own milk remains essential, as it provides specific immunological nutrients for infant health. This study aimed to investigate the relationship between perception factors within the Health Belief Model (HBM) and breastfeeding preparation behaviors among mothers of preterm infants receiving DHM.

Methods: A descriptive correlational study was employed to examine the relationship between perception factors—including perceived susceptibility to and severity of illness, perceived benefits, perceived barriers, and perceived self-efficacy—and breastfeeding preparation …

Determination Of Six Human Milk Oligosaccharides In Infant Formula Milk Powder By Ion Chromatography, Zhang Jiaqi, Li Yunxuan, Wang Lulu, Zhang Shuifeng, Pan Xiangjie, Shi Yuanxu, Que Liming

Food and Machinery

［Objective］ To establish an ion chromatography method for the simultaneous determination of six human milk oligosaccharides (HMOs ) in infant formula powder.［Methods］ The samples were enzymatically hydrolyzed using fructanase.Gradient elution was performed with a mobile phase consisting of water,0.5 mol/L sodium hydroxide,and 0.3 mol/L sodium acetate.Separation was carried out on a Thermo Fisher CarboPac ™ PA1 Analytical Column,and detection was performed using ion chromatography with pulsed amperometric detection.［Results］ In milk powder,2'-fucosyllactose (2'-FL),3-fucosyllactose (3-FL),and lacto -N-tetraose (LNT ) showed good linearity within the range of 1~100 mg/L,while lacto -N-neotetraose (LNnT ),3'-sialyllactose (3'-SL),and 6'-sialyllactose (6'-SL) exhibited good linearity in the range of …

Design And Test Of Flat Grinding Type Germ-Remained Rice Milling Machine, Ren Hongchen, Xu Aidi, Sun Binghua, Jin Dehai, Li Jing, Sun Daming, Yan Jingfeng

Food and Machinery

［Objective］ To address the challenges of retaining the germ in rice with remained germ,balancing nutrition,sensory qualities,and palatability.［Methods］ A technical design proposal for a flat grinding type germ -remained rice milling machine is introduced,which combines active grinding with a flat grinding belt and passive grinding with a flexible blade group.The milling process involves rolling and grinding the rice grains on a flat surface to achieve precise,layer -by-layer grinding.The approach employs multiple flexible processing stages combined with appropriate grinding to ensure a high germ -remained rate and good whiteness of the rice.Northeast China -produced japonica rice is used as the test material,with …

Effect Of Processing Aids On The Quality Of Microwave Foam-Dried Locust Honey, Hao Bingting, Wang Yingqiang, Shi Xixiong, Zhao Hongxia

Food and Machinery

［Objective］ To investigate the effect of various processing aids on the quality of locust honey dried by microwave -assisted foam drying technology.［Methods］ Six processing aids,including egg white powder,soy protein isolate,maltodextrin,β-cyclodextrin,soluble starch,and sodium carboxymethyl cellulose,were selected to study their effects on foaming properties,moisture content,hygroscopicity,color,solubility,and sensory scores of honey.A regression model for honey quality control was established through response surface optimization experiments.［Results］ The foam expansion and foam stability of egg white powder were better than those of soy protein isolate.The hygroscopicity of maltodextrin and egg white powder was better than that of other processing aids,and hygroscopicity decreased with increasing aid concentration.When maltodextrin …

Optimization Of Decolorization Process And Its Effect On Flavor Of Sardine Fish Head Protein Peptide, Wang Zhengming, Tao Ningping, Wei Wencong, Wang Fengqiujie

Food and Machinery

［Objective］ To improve the color and flavor of enzymatically prepared sardine fish head protein peptide (SFHP ).［Methods］ The optimal absorption wavelength of the SFHP solution was determined using a spectrophotometer.The effects of three decolorizing agents,including their dosage,decolorization time,and temperature,on the decolorization efficiency of SFHP were investigated.A plate -and-frame filtration pilot -scale test was conducted to validate the decolorizing and filtration -enhancing effects of the decolorizing agents.Flavor profiles before and after decolorization were analyzed using an electronic nose (E-nose ) and electronic tongue (E-tongue ).［Results］ The optimal absorption wavelength of the SFHP solution was 220 nm.The optimal decolorization conditions were determined …

Research Progress On Deep Eutectic Solvents In Extraction Of Polysaccharides From Edible Mushrooms, Pei Longying, Liu Wei, Wang Sidan, Wang Xiaoyu, Zhou Yuting, Xie Chaoying

Food and Machinery

Polysaccharides in edible mushrooms possess biological activities such as immunomodulation,antioxidant effects,anticancer properties,and regulation of intestinal microbiota.Deep eutectic solvent (DES ) extraction has gained attention as a novel method for polysaccharide extraction.This article outlines the composition,synthesis methods,and important properties of DES,summarizes and discusses research on polysaccharide extraction from edible mushrooms using DES in China and abroad,and further explores the limitations of the DES extraction method.

Research Progress On Extraction And Biological Activity Of Corn Silk Polysaccharides, Xu Xiuying, Wen Liankui, He Yang, Yu Lei

Food and Machinery

Corn silk,the dried style and stigma of corn,is a traditional Chinese herbal medicine and functional food ingredient.Polysaccharides,one of the main bioactive components of corn silk,exhibit hypoglycemic,hypolipidemic,antibacterial,and anti -inflammatory effects.This article reviews the extraction methods and biological activities of corn silk polysaccharides,summarizing the process parameters,advantages,and disadvantages of different extraction methods,as well as the biological activities and mechanisms of action of corn silk polysaccharides,which are current research hotspots.

Research Progress On Quality Enhancement Of Rice Bread, Guo Tian, Huo Jian, Cheng Hao, Yi Cuiping

Food and Machinery

Owing to the low allergenicity and high digestibility,rice bread has become an important alternative product to traditional wheat bread.However,the molecular characteristics of rice make it challenging for rice to form a continuous viscoelastic network akin to gluten.Consequently,the gas retention efficiency of rice dough is substantially diminished,resulting in quality degradation problems in rice bread,such as inadequate flavor,textural hardening,crumbling,and easy staling.To this end,both domestic and international scholars have examined the variations in the moisture content,texture,color,and flavor of rice bread.Meanwhile,various strategies for quality enhancement are summarized,including the selection and pretreatment of raw materials,exogenous improvement,sourdough fermentation technology,frozen dough techniques,and innovative baking technology.Finally,an experimental reference …

Research Progress On The Protective Effect And Mechanism Of Inulin Against Liver Injury, Yun Hang, Guo Yifan, Wang Peiwen, Xu Yanrui

Food and Machinery

Liver injury is caused by one or more factors acting on the liver,damaging liver cells and resulting in pathological changes in the liver,as well as elevated serum transaminases.In severe cases,it may lead to liver failure and hepatic encephalopathy.Inulin is a common dietary fiber with various biological activities,including anti -inflammatory,antioxidant,anti -cancer properties,and the regulation of gut microbiota.These biological activities are closely related to the protection of liver health.This article reviews the protective effects of inulin against various types of liver injury,summarizes the mechanisms underlying its protective effects on the liver,and looks forward to future research directions.

Effect Of Electric Steamer Steaming Parameters On The Cooking Quality Of Eggplant, Zhao Wenyu, Xu Yanshun, Li Yujing, Fang Kun, Yao Qing, He Xiaoyan

Food and Machinery

［Objective］ To evaluate the cooking quality of food based on its color characteristics.［Methods］ Using heating curves,color measurements,and anthocyanin content as evaluation indexes,the effect of steaming power,anaerobic environment,surface temperature change of eggplant,and steaming volume on the color of eggplant was investigated.［Results］ Eggplants steamed in a steamer pot had significantly better color compared to those steamed in a steam oven.The steaming power,volume,anaerobic environment,and surface temperature of the eggplant all affected its color and anthocyanin loss rate.As the steaming power increased and the steaming volume decreased,the anthocyanin loss rate decreased.The lowest anthocyanin loss rate of 44.27% occurred when the steaming power was 2 …

Effects Of Repeated Freezing-Thawing On Physicochemical Properties And Quality Of Freshwater Silver Carp Bladder, Huang Darong, Feng Rui, Zhong Biluan, Tian Jianxin, Liang Jiehua, Zhang Yu

Food and Machinery

［Objective］ To investigate the effects of different freezing and thawing cycles on the physicochemical properties and quality of silver carp fish bladder.［Methods］ Fresh silver carp fish bladder was used as the research material.The trends of water retention,color difference,textural properties,basic nutrient content,and microstructure of the fish bladder were analyzed under different freezing -thawing cycles.［Results］ As the number of freeze -thaw cycles increased,the cooking swelling rate,brightness value,yellowness value,hardness,cohesion,adhesiveness,collagen content,and total protein content of the silver carp fish bladder all decreased significantly (P<0.05),with reductions of 45.52%,10.90%,48.99%,47.45%,13.56%,58.04%,10.54%,and 4.57%,respectively.The decreases in moisture,fat,and ash content were relatively low.The thawing loss rate and color redness value both increased significantly (P<0.05),by 4.80% and 140.72%,respectively.The microstructure of the silver carp fish bladder gradually deteriorated and broke down during the repeated freezing -thawing process.［Conclusion］ Based on the quality deterioration during the comprehensive freezing -thawing process,limiting the freezing -thawing cycles to no more than five can effectively preserve the characteristics and quality of the silver carp fish bladder.

In Vitro Digestion Characteristics Of Steam-Exploded Oats And Their Effects On Obesity Induced By High-Fat Diet In Mice, Wang Jing, Kuang Chuyu, Xia Zhihui, Cai Jiaru, Wang Xufeng, Luo Kaiyun

Food and Machinery

［Objective］ To investigate the effects of steam explosion pretreatment on the microstructure of oats,the content of β-glucan,the digestion characteristics of starch,and its effect on obesity in mice fed a high -fat diet.［Methods］ The effects of steam explosion treatment under different pressures (0.3,0.5 MPa ) and time (30,60,90 s) on the microstructure of oats and the composition of β-glucan are investigated,and the obesity inhibitory effect of steam -exploded oats in a simulated high -fat diet environment is studied.［Results］ Steam explosion can destroy the ordered structure of the oat cell wall,increase the content of slowly digestible starch,the content and dissolution rate of …

Effects Of Heat Moist Treatment On Γ-Aminobutyric Acid Accumulation , Polyphenol Content , And Antioxidant Activity Of Red Kidney Beans, Zhang Siqi, Zhou Sumei, Hou Dianzhi, Cui Yajun, Wang Li

Food and Machinery

［Objective］ To investigate the effect of heat moist treatment on the γ-aminobutyric acid (GABA ) content of different varieties of red kidney beans and to screen out the red kidney bean varieties with the strongest GABA accumulation capacity.At the same time,the changes in phenolic content and antioxidant activity of red kidney beans after heat moist treatment are investigated.［Methods］ This paper determines the GABA content in red kidney beans before and after heat moist treatment by high performance liquid chromatography (HPLC ) and conducts correlation analyses of GABA accumulation with free amino acid content and GABA key metabolic enzyme activities in …

Thermal Rheological Properties Of Heat-Moisture Modified And Its Application In Multigrain Cookies, Thi Huyen Trang, Li Xianghong, Miao Jinxu, Wang Faxiang, Liu Yongle, Li Shuang

Food and Machinery

［Objective］ To develop low -burden,high -nutrient functional baked foods.［Methods］ A single -factor experimental design is employed,with rapid visco analyzer,rheometer,and differential scanning calorimeter to analyze the physicochemical properties of heat -moisture modified wheat flour.The cookie formula is optimized based on sensory evaluation.［Results］ Heat -moisture treatment significantly enhances the pasting stability and resistant starch content of wheat flour.The optimal auxiliary ingredient formula is 50 g of heat-moisture modified wheat flour,20 g of oat flour,10 g of mung bean flour,and 6 g of resistant dextrin powder.Compared with the control group,the cookies made from the experimental formula show a significantly lower digestibility,with a glycemic …

Research Progress On Methods For Evaluating The Effect Of Milk Desensitization, Xu Chenyu, Lu Dingqiang, Wang Qian, Li Ming, Wu Wenling, Song Qingwei

Food and Machinery

Food allergies are becoming an increasingly serious issue,and milk,as one of the major allergens,severely affects the daily lives of individuals with allergies.This article reviews the recent research progress on methods for assessing the desensitization of milk allergenicity from the perspectives of protein structural changes,IgE/IgG binding capacity,animal sensitization models,in vitro digestion models,and cell degranulation assays.It also looks forward to the future directions of research on methods for evaluating the effectiveness of milk desensitization.

Extraction Of Cereal Polyphenols And Their Application In Aquatic Products, Wen Shuyao, Yao Yile, Ye Linlin, Deng Na, Zhang Bo, Li Hui, Wang Jianhui

Food and Machinery

Cereal polyphenols mainly exist in free or bound states,including two major categories:phenolic acids and flavonoids.Their contents are affected by factors including cereal varieties,germination conditions,processing methods,and storage conditions.The extraction methods of cereal polyphenols are mainly acid,alkali,enzymatic hydrolysis,and supercritical fluid extraction methods.This paper reviews factors affecting the cereal polyphenol types,extraction methods,contents,and titers.Additionally,this paper looks forward to their application in aquatic product preservation.