Digital Commons Network^™

Entecavir Long-Term Treatment In Nucleoside/Nucleotide-Naïve Young Children With Perinatally-Acquired Hbeag-Positive Chronic Hepatitis: A Single Center Study, Hanan Fouad, Magda Sabry, Hany Abd Elaziz, Mohamed Rabea, Shaimaa El Abrak

Journal of Pediatric Infectious Diseases

Objective: We aimed to estimate Entecavir's long-term on-treatment safety and efficacy in young children with HBeAg-positive chronic hepatitis, who acquired perinatally Methods: This is an observational study of 14 nucleoside/nucleotide-naïve children with HBeAg-positive chronic hepatitis who were candidates for Entecavir. Treatment eligibility included persistent elevation of alanine aminotransferase (ALT) for at least 6 months, high HBV viremia, and moderate to severe hepatic inflammation and/or fibrosis. Results: Participants received Entecavir for up to 5 years (2-5). Their ages at baseline were 5.1 ± 1.6 years (range, 3-8), and they had an equal gender distribution. None had coinfection with hepatitis C or …

Pakistan’S Experience With The Imf, 2000–2004, Ishrat Husain Dr.

Faculty Research - Talks, Speeches, & Discourse

Pakistan’s relationship with the IMF during the 2000 – 2004 period was quite unique and distinctive. Unlike the earlier eight agreements that were concluded with the IMF during 1988-99 and were never implemented beyond the first tranche release it was only in this period that two successive agreements – a nine month Stand-by Arrangement (SBA) in the year 2000 followed by a three year Poverty Reduction and Growth Facility (PRGF) were successfully completed. All the sixteen reviews by IMF staff were completed and eleven successive tranches were drawn on time without any extension or interruption. The last two tranches were …

A Twisting Trail To Diagnosis: Unraveling Morvan’S Syndrome In Caspr2-Associated Autoimmune Encephalitis, Yashfeen M

Journal Of Indian Physician Associates

This case snippet describes the diagnostic journey and clinical management of a 72-year-old gentleman who presented with progressive cognitive decline, involuntary myoclonus, and severe insomnia. Through a detailed clinical workup, including electromyography and antibody testing, he was diagnosed with Contactin-Associated Protein-Like 2 (CASPR2) antibody-associated autoimmune encephalitis manifesting as Morvan’s syndrome, a rare but reversible neuroimmunological disorder. Prompt initiation of immunotherapy led to gradual improvement, underscoring the value of clinical suspicion, multidisciplinary care, and early intervention. This case serves as a reminder to consider autoimmune etiologies in atypical neuropsychiatric presentations, especially in elderly patients.

A Vision With A Business: Kerista Commune’S Utopian Capitalism, Annelise Vought

Communal Societies

No abstract provided.

Far Out West: A Utopian Comic Adventure, Cheryl Coulthard

Communal Societies

No abstract provided.

Ucc Minutes Oct 10, 2025, Undergraduate Curriculum Council

Undergraduate Currirculum Committee Minutes

No abstract provided.

Glucagon-Like Peptide 1 Receptor Agonists And The Clinical Outcomes Of Inflammatory Bowel Disease: A Systematic Review And Meta-Analysis, Ahmed B. Bayoumy, Lindsay M. Clarke, Parakkal Deepak, Aakash Desai, Priya Sehgal, Uri Gorelik, Haggai Bar-Yoseph, Marie Villumsen, Chris J. J. Mulder, Dirk J. Stenvers, Maarten E. Tushuizen, Nanne K. H. De Boer

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Prior studies showed worse outcomes in obese inflammatory bowel disease (IBD) patients, especially those related to hospitalizations, surgery, and steroid-free remission. Glucagon-like peptide-1 receptor agonists (GLP1-RAs) have demonstrated significant metabolic benefits for patients with type 2 diabetes mellitus (T2DM) and obesity. Hence, GLP1-RAs may improve clinical outcomes in patients with IBD, especially those with obesity. The objective was to systematically evaluate the impact of GLP1-RAs on clinical outcomes in patients with IBD.

METHODS: A comprehensive literature search was performed using the databases PubMed, Embase, Web of Science, and Cochrane Library from inception to March 15, 2025. Studies reporting outcomes …

Evaluation Of An In Situ Forming Composite Hydrogel Based On Gelatin–Sodium Alginate– Polyethylene Oxide For Biomedical Applications: Effect Of Incorporated Sophora Japonica On Hydrogel Performance, Samar A. Salim

Nanotechnology Research Centre

Hydrogels are ideal candidates for biomedical applications such as wound healing, tissue engineering, and bone regeneration due to their porosity and similarity to the extracellular matrix of humans. A gelatin/ sodium alginate (SA) hydrogel with the inclusion of polyethylene oxide (PEO) was utilized to achieve enhanced mechanical strength. Hydrogels were prepared at different ratios of polymer solutions to select the hydrogel that exhibited an optimal gelation time. Sophora japonica, a plant leaf extract (SJLE) rich in flavonoids and isoflavonoids, was added to the hydrogel to enhance tissue repair. The developed hydrogels were extensively characterized for their morphology, porosity, and swelling …

Development And Validation Of Clinical Screening Systems For Cushing Disease In The United States, Jorge E. Salcedo-Sifuentes, Sonal Mehta, Carter M. Suryadevara, Marvin Bergsneider, Kevin C. J. Yuen, Paul A. Gardner, Julie M. Silverstein, Albert H. Kim, James J. Evans, Garni Barkhoudarian, Juan C. Fernandez-Miranda, William T. Couldwell, Robert C. Rennert, Varun R. Kshettry, Kyle C. Wu, Carolina Benjamin, Gabriel Zada, Michael R. Chicoine, Jamie J. Van Gompel, Michael P. Catalino, Michael Karsy, Adam Mamelak, Ildiko Torok, Trevor Low, Won Kim, Donato R. Pacione, Nidhi Agrawal

Department of Neurosurgery Faculty Papers

PURPOSE: Clinical screening systems (CSSs) for Cushing syndrome (CS) validated in Europe have not been evaluated for CS or Cushing disease (CD) in the United States (US). We aimed to evaluate existing CSSs in US patients and develop two new symptom-based CSSs to identify patients with high pre-test probability of disease warranting referral for definitive biochemical workup-one for broad CS screening and one specifically for CD.

METHODS: Data were obtained from the Registry of Adenomas of the Pituitary and Related Disorders (RAPID)-comprising 615 patients who underwent transnasal transsphenoidal resection for CD at one of 11 US pituitary centers, the Centers …

Board Of Trustees Agenda, Oct. 10 2025, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

2017 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2016 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2015 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2013 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2012 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2011 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2010 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2009 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2008 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2007 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2005 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Peer-Led Multicomponent Lifestyle Intervention Improves Function And Physical Activity In Older Veterans With Dysmobility, B Friedman, J Giffuni, E Dennis, R Patel, J Rekant, O Addison

International Journal of Exercise Science: Conference Proceedings

a

Effect Of Dietary Intake On Exercise Performance In Collegiate Rowers, J Garay, S Vettamvelil, M Voss

International Journal of Exercise Science: Conference Proceedings

a

Age-Varying Associations Between Disrupted Circadian Rest-Activity Rhythms And Frailty Among 7,236 U.S. Adults, J Kim, J Kenyon, J Geller, E Park, J Lee, D Kirkman, L Sargent, Y Kim

International Journal of Exercise Science: Conference Proceedings

a

The Impact Of A Baseball Season On Body Composition In Ncaa Division Ii Baseball Pitchers, C Saker, B Snyder, B Finn, S Davis Facsm, Darrin Lenhart, S Muford

International Journal of Exercise Science: Conference Proceedings

a

Agreement Between Self-Reported And Accelerometer Derived Sleep Durations, M Alidadi, T Barreira, K Harmon, Y Moon, M Armstrong

International Journal of Exercise Science: Conference Proceedings

a

Holy Cross Magazine, Vol. 59, No. 3, Fall 2025, College Of The Holy Cross

Holy Cross Magazine

Frank Kartheiser ’72 is Comfortable With Your Discomfort
The community organizer and co-founder of the Mustard Seed soup kitchen and food pantry has been feeding the poor and clothing the hungry of Worcester for more than 50 years. His greatest dream is that it closes, yet the need continues to grow.
Story by Marybeth Reilly-McGreen ’89
Photography by Caroline Axvig

The Catholic Church’s Best Kept Secret
Rooted in Scripture and the Church's understanding of human dignity, Catholic Social Teaching helps people live out their faith in the world.
Story by Marybeth Reilly-McGreen ’89
Photography by Michael Ivins

Working to Get …

Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo

Faculty Publications

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, thus, there is an urgent need to develop more effective therapeutic options for this dismal condition. Tumor-infiltrating lymphocytes (TILs) are associated with improved response to immune checkpoint blockade in HCC, but their low abundance in most cases limits their therapeutic efficacy. Here, we demonstrate, in mice, that low-dose intratumoral immunovirotherapy with the trivalent measles, mumps, and rubella vaccine (MMR) induces superior tumor-growth delay and extended host survival compared to individually administered vaccines for measles, mumps, or rubella viruses. Further, our results show that MMR therapy synergizes with PD-1 and …

Ai In Adipose Imaging: Revolutionizing Visceral Adipose Tissue, Ectopic Fat, And Cardiovascular Risk Assessment, Sneha R. Kandi, Sanjay Rajagopalan, Ian J. Neeland

Faculty Scholarship

Purpose of Review: This review explores the role of artificial intelligence (AI) in visceral adipose tissue (VAT) and ectopic fat imaging. It aims to evaluate how AI may be used to enhance the efficiency and accuracy of cardiovascular disease (CVD) risk assessment. It addresses key questions regarding AI’s capabilities in risk prediction, segmentation, and integration with large volume data for CVD risk assessment. Recent Findings: Recent studies demonstrate that AI, powered by deep learning models, significantly improve VAT and ectopic fat segmentation. AI can also be used to facilitate early detection of cardiometabolic risks and allows integration of imaging with …

Artificial Intelligence And Energy Democracy, Heather E. Payne, Joel B. Eisen

San Diego Law Review

Artificial intelligence (AI) is quickly transforming many professional activities, and the electric grid has already started to see adverse impacts from its use, such as the burgeoning demand for electricity from data centers. This Article acknowledges these impacts, but also demonstrates that AI can be put to beneficial use on the grid. It proposes and describes a specific use of AI: assisting citizen intervenors in public utility commission (PUC) proceedings, who currently face barriers to participation due to the technical complexity and confidentiality imposed by monopoly utilities. The Article describes how AI can assist intervenors to overcome the barriers to …