Digital Commons Network^™

Rest For Self-Care: Improving Student Nurses’ Health, Karen Higgins, Janice E. Hawkins, Ingrid Mahoney, Jamela M. Martin, Beth Tremblay, Lynn L. Wiles

Creating Healthy Work Environments (CHWE)

The Essentials for nursing education prioritize improving students’ health and resilience. In this presentation, we describe how nursing students used the REST mnemonic to create self-care plans. At the end of the semester, students reported increased engagement in self-care activities and a new awareness of the need for self-care.

Detailed abstract attached.

Defining Endotypes Of Bronchopulmonary Dysplasia In Preterm Infants To Improve Precision-Based Therapies., Megha Sharma, Gangaram Akangire, Noah H. Hillman, Winston M. Manimtim, Mark Ivan Attard, Venkatesh Sampath

Manuscripts, Articles, Book Chapters and Other Papers

Bronchopulmonary dysplasia (BPD) remains a debilitating disease in premature infants. The chronic pathogenesis of BPD with complex prenatal and postnatal programming challenges attempts at precisely defining or treating disease. While existing BPD definitions categorize disease severity, a lack of consideration of disease heterogeneity and endotypes has contributed to the failure of clinical trials to improve BPD outcomes. Recent studies have used advanced lung imaging techniques, echocardiography, and lung function tests to identify airway, parenchymal, and vascular BPD endotypes. These endotypes carry different prognoses and require endotype-specific treatment strategies to optimize infant outcomes. In this Review, we focus on the pathogenic …

Rtx-303, An Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates Parp Inhibitors In Brca Mutant Tumors, Gurushankar Chandramouly, William Fried, John Gordon, Douglas Ralph, Channita Keuk, Sangeeta Kumari, Mercy Ramanjulu, William Auerbacher, Leonid Minakhin, Taylor Tredinnick, Bernadette Tiberi, George Morton, Robert Betsch, Kathy Q. Cai, Umeshkumar M Vekariya, Mrityunjay Tyagi, Tomasz Skorski, Sergey Karakashev, Neil Johnson, Wayne E. Childers, Xiaojiang S. Chen, Richard T. Pomerantz

Department of Biochemistry and Molecular Biology Faculty Papers

DNA polymerase θ (Polθ) is a polymerase-helicase fusion protein that is synthetically lethal with homologous recombination (HR) factors, such as BRCA1/2, and confers resistance to PARP inhibitors (PARPi) and other genotoxic cancer therapies. Previously developed Polθ polymerase (Polθ-pol) inhibitors (Polθi) exhibited limited pharmacological activity and metabolic stability, warranting the development of a Polθi with improved drug-like properties. Here, we developed RTx-303, a selective allosteric small-molecule Polθ-pol inhibitor that exhibits 5.1 nM IC50, 88% oral bioavailability, and a prolonged half-life along with its equipotent metabolite. X-ray crystallography highlights the development of a solvent-exposed side-chain that is essential for the optimal drug-like …

The Genome Sequence Of The Hemlock Woolly Adelgid, Adelges Tsugae Annand 1924, Bryan M.T. Brunet, Dustin T. Dial, Gaelen R. Burke, Carol D. Von Dohlen, Julia Douglas Freitas, Haley Sanderson, Afiya R. Chida, Samantha J. Jones, Fergal J. Martin, Leanne Haggerty, Stephen W. Scherer, Ioannis Ragoussis, Steven J.M. Jones, Robert G. Foottit, Nathan P. Havill

Biology Faculty Publications

The genome of the hemlock woolly adelgid (Adelges tsugae) is presented in 10 chromosomal pseudomolecules along with 132 unplaced scaffolds for a combined length of 216.56 Mb. The genome is highly contiguous with an N50 of 20.54 Mb and its longest scaffold 37.41 Mb in length. The assembly recovered 97.7% of benchmarked universal single-copy Hemiptera orthologs (BUSCO) with an overall completion score of 98.6%. On the basis of chromosomal synteny with other aphid genomes, the hemlock woolly adelgid’s genome is composed of eight autosomes and two sex (X) chromosomes. Annotation of the assembly identified 11,800 coding genes, 1,930 …

Mir147 Promotes Mucosal Integrity And Healing In Intestinal Inflammation, Agnieszka K Czopik, Arash Dabiri, Chia-Hao Tung, Victoria Vaughn, Xiangsheng Huang, Jinlian Wang, Hui Li, Nicolas F Moreno, Natalia V Piwko, Katherine Figarella, Hongfang Liu, Zhongming Zhao, Xiaoyi Yuan, Holger K Eltzschig

Faculty, Staff and Student Publications

The intestinal mucosal epithelium forms a barrier between luminal contents and the body. MicroRNAs (miRNAs) regulate mucosal homeostasis by controlling inflammatory responses and structural integrity. Here, we discovered a protective role for miR147 in intestinal inflammation using a miR147tdTomato reporter mouse. miR147 was enriched in the intestines, with the highest expression in the colonic epithelial cells at the luminal surface, with prominent expression in differentiated enterocytes. Mice with general or intestinal epithelial deletion of miR147 showed increased intestinal inflammation and diminished mucosal healing during colitis. RNA sequencing of miR147-deficient cells showed dysregulated immune signaling, with upregulated proinflammatory cytokine pathways and …

2025-10-22 Message From The President, Morehead State University. Office Of The President.

Staff Congress Records

A message sent by the Office of the President to the campus community on October 22, 2025, regarding upcoming events on campus, homecoming, Board of Regents meeting, academic and personnel calendars, and congratulatory remarks.

On The Ecological Impact Of Prehistoric Hunter-Gatherers In Europe: Early Holocene (Mesolithic) And Last Interglacial (Neanderthal) Foragers Compared, Anastasia Nikulina, Anhelina Zapolska, Maria Antonia Serge, Didier M. Roche, Florence Mazier, Marco Davoli, Elena A. Pearce, Jens Christian Svenning, Dave Van Wees, Ralph Fyfe, Katharine Macdonald, Wil Roebroeks, Fulco Scherjon

School of Geography, Earth and Environmental Sciences

Recent studies have highlighted evidence of human impact on landscapes dating back to the Late Pleistocene–long before the advent of agriculture. Quantifying the extent of vegetation transformations by hunter-gatherers remains a major research challenge. We address this challenge by comparing climate-based potential natural vegetation cover with pollen-based vegetation reconstructions for the Last Interglacial and the Early Holocene. Differences between these datasets suggest that climate alone cannot fully explain the pollen-based vegetation patterns in Europe during these periods. To explore this issue, we used an upgraded version of the HUMan impact on LANDscapes (HUMLAND) agent-based model (ABM), combined with a genetic …

Spectrum, Volume 55, Issue 6, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Ongoing Government Shutdown Reaches Week Four -- West Campus Welcomes “The Evans Family Atrium” -- Step by Step: The Walk to End Alzheimer’s -- Navigating AI in the Classroom -- Is Sports Betting Impacting College Students? -- Pioneers’ Basketball Ready for Season Return

Myocardial Protection By Acidic Amino Acids And Natural Dipeptides: Potential For An Underused Resource, N. King

School of Biomedical Sciences

Stopping then restarting the blood flow to the heart can cause ischaemia reperfusion (IR) injury. This can happen during revascularisation following a myocardial infarction and during on pump cardiac surgery using cardioplegic arrest. Despite extensive studies to identify cardioprotective interventions, the myocardium continues to sustain significant injury. Therefore, there is a need to identify agents that can be used during IR. This review focuses on the potential cardioprotective role for acidic amino acids and natural dipeptides using evidence from experimental studies and clinical trials with particular emphasis on their membrane transport. Acidic amino acids are present at high concentration in …

The Effects Of Combined Fasting And Exercise On Inflammatory Cytokine Concentrations In Healthy Adults: A Randomized Crossover Study, Landon S. Deru, Austin F. Duersch, Spencer C. Cleverly, Hunter D. Chamberlain, Elizabeth Z. Gipson, Parker G. Graves, Cameron G. Jacobsen, Larry A. Tucker, Bruce W. Bailey

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 1252-1268, 2025. https://doi.org/10.70252/APHT9483 The object was to assess the effects of adding exercise to a 36-hour fast on the inflammatory cytokines IL-6, TNF-α, and MCP-1. The study was a randomized crossover design with counterbalanced conditions in community members living near a single academic institution. Participants included twenty healthy adults (11 male). The intervention consisted of two 36-h water-only fasts, one of which was initiated with a bout of treadmill exercise. Venous blood was taken at baseline, 12-h, 24-h, and 36-h of fasting. Area under the curve and timepoint analyses were computed. The area under …

Incidence And Risk Factors Of Metabolic Syndrome In Track And Field Throwing Athletes, Taylor Browning, Samuel Headley, Elizabeth M. Mullin, Margaret T. Jones, Andrew R. Jagim, Jennifer Fields

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 1199-1211, 2025. https://doi.org/10.70252/HOKT7948 Track and field (T&F) throwers are a prominent subgroup of athletes that may be at risk for the development of Metabolic Syndrome (MetSyn) and other cardiometabolic disease conditions. However, limited research exists examining the prevalence of MetSyn in these athletes. Therefore, the purpose of this study was to examine the incidence of MetSyn and associated risk factors in collegiate throwers. Collegiate Division I men (n=17) and women (n=4) T&F throwers participated in a single day of lab assessments, which included anthropometrics, body composition, blood pressure, a venous blood draw, and aerobic …

Upper Extremity Asymmetries In Collegiate Tennis Players Compared To An Athletic Control Of Runners, Elizabeth A. Cafferty, Dale R. Wagner, Brennan J. Thompson

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 1151-1165, 2025. https://doi.org/10.70252/MDRK9289 Previous research on limb asymmetries of athletes participating in dominant-sided sports lacks an athletic control group. This study aimed to determine the magnitude of upper limb asymmetries in dominant-sided athletes (tennis players) compared to nondominant-sided athletes (cross-country runners). Men and women university athletes (10 tennis, 11 cross-country) participated. Dual-energy x-ray absorptiometry (DXA) was used to measure bone mineral content (BMC), bone mineral density (BMD), and lean mass (LM) of the whole body, upper extremities, and forearms. Circumference measurements were taken at mid-biceps and widest part of the forearms. Bony breadth of …

An Example Analysis For A Gender-Inclusive Approach In Sport And Exercise Science Research Using Fitbit Outcomes From The All Of Us Research Program Dataset, James W. Navalta, Dustin W. Davis, Jafra D. Thomas, Whitley J. Stone

International Journal of Exercise Science

International Journal of Exercise Science 18(1): 1133-1141, 2025. https://doi.org/10.70252/HRNQ4501 Prevalence studies with wearable devices are used to understand disparities in health-related physical activity behaviors and whether interventions are efficacious. However, studies have been limited to a binary definition of sex. This example analysis aimed to demonstrate how researchers can investigate differences in data beyond the sex-gender binary. Using a cross-sectional analysis of the All of Us Research Program dataset, participants' self-identified gender was categorized into Cisgender Female (n = 10,401), Additional Options (n = 27), Non-binary (n = 84), Transgender (n = 17), and Cisgender Male …

Ethnic Differences In Health-Related Quality Of Life, Physical Activity, And Health Locus Of Control, Kimberly Feiler

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1072-1085, 2025. https://doi.org/10.70252/STUM6367 This research aimed to better understand the differences in health-related quality of life (HRQoL: general health, physical functioning), physical activity (PA), and health locus of control (HLOC: internal, external-chance, external-powerful others, God) among various ethnic groups. The study’s sample included 185 individuals, 22 - 81 years of age, who were attending or employed by one of three religiously-affiliated higher education institutions during the 2020-2021 academic year. Participants voluntarily answered questions about their ethnic identity, HRQoL, PA level, and HLOC. To analyze the interaction of HRQoL, PA, and HLOC, a multiple regression …

Purple Tomatoes Boost Nutrition Crop Value And Create New Opportunities For United States (U.S) Agriculture, Tariq Alam

Agronomic Crops

The agricultural landscape in the United States is continually evolving, with growers and the tomato industry seeking innovative ways to meet consumer demands while enhancing profitability. The introduction of both bioengineered and classically bred anthocyanins-enriched purple tomatoes presents a unique opportunity for U.S. growers to cultivate a high-value crop that appeals to niche markets and commands premium pricing. Bioengineered purple tomatoes achieve high anthocyanin levels through the introduction of snapdragon transcription factors, while classically bred 'Indigo Rose' purple tomatoes are developed via classical breeding methods, providing an alternative for consumers who prefer traditionally bred products. Specifically, the purple tomato holds …

Dairy And Food Science Student Newsletter, October 21, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

2025 October 21 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Myfoodrx: A Personalized Food-As-Medicine Mhealth Application For Food-Insecure Adults With Chronic Conditions, Jay Hiteshkumar Jariwala

USF Tampa Graduate Theses and Dissertations

Food insecurity (FI) remains a persistent public health challenge in the United States, disproportionately affecting underserved populations and contributing to higher rates of chronic conditions such as diabetes, hypertension, and obesity. Traditional Food-as-Medicine programs have emerged as promising interventions, but often follow a generalized, non-personalized approach that limits long-term effectiveness, especially among diverse, high-risk communities. This thesis presents MyFoodRx, a personalized mobile health (mHealth) application designed to address the intersection of food insecurity and chronic disease through tailored nutritional guidance, real-time pantry integration, and adaptive educational content.

Developed through a User-Centered Design (UCD) process, MyFoodRx leverages a modular client–server architecture, …

Marigold-Silver Nanoparticles (Agnps) Complex: Characterization, Therapeutic Potential, And Future Approaches For Lung Injury Via Antioxidant And Anti-Inflammatory Effects, Navdeep Kaur

USF Tampa Graduate Theses and Dissertations

Chronic respiratory diseases (CRDs) and other lung conditions are a key cause of the problems facing global health, as they greatly increase morbidity, death, and the financial burden. In order to achieve the third Sustainable Development Goal of the United Nations, which is to reduce premature mortality from non-communicable illnesses by one-third by 2030, updated epidemiological statistics are crucial for directing prevention, control, and treatment measures. One of the major reasons of illness and death globally is chronic obstructive pulmonary disease (COPD). Lung damage and the emergence of CRDs, such as asthma, emphysema, COPD, and other respiratory disorders, are largely …

A Global Overview Of Anatomical Science Education And Its Present And Future Role In Biomedical Curricula, Michael Hortsch, Virginia Claudia Carneiro Girão-Carmona, Ana Caroline Rocha De Melo Leite, Ilias P. Nikas, Margaret K. Gatumu, Nii Koney Kwaku Koney, Benjamin Arko-Boham, Doris George Yohannan, Aswathy Maria Oommen, Yan Li, Jian Yang, Alexandra F. Trollope, Amanda J. Meyer, Sonya E. Van Nuland

School of Medicine Faculty Publications

The four main anatomical sciences, gross anatomy, histology, neuroanatomy, and embryology, are fundamental subjects for most health professionals and biomedical students. Usually taught as part of preclinical basic science training, the anatomical sciences provide a structural understanding of human or animal bodies at both macroscopic and microscopic levels. This overview characterizes how the anatomical sciences are currently taught around the globe, highlighting similarities, differences, and recent curricular transformations that were partially in response to the COVID-19 pandemic. Globally, educators of the anatomical sciences navigate similar pressures, including expectations of curricular integration and reduced time for anatomical teaching. Student-centered teaching approaches …

Naturalizing Motherhood: Neoliberal Femininity And The Re-Traditionalization Of Gender In Turkey, Canan Tanir

Sociology Faculty Publications

The recent trends in the social construction of “good mothering” through “naturalism” have become remarkably definitive in Turkey in the last decade. This study presents data from in-depth interviews with naturalist mothers in Istanbul demonstrating four operative mechanisms in their narratives with regard to their conception of gender. Practices of naturalist motherhood depart from systemic criticism and opposition to the ongoing neoliberal conservatization process in Turkey. However, at the same time, they are congruent with the normalization of a patriarchal gender order in this context. I propose that addressing this controversy is contingent on problematizing the focus on choice and …

Towards Mitigation Of Hallucination For Llm-Empowered Agents: Progressive Generalization Bound Exploration And Watchdog Monitor, Siyuan Liu, Wenjing Liu, Zhiwei Xu, Xin Wang, Bo Chen, Tao Li

Michigan Tech Publications

Empowered by large language models (LLMs), intelligent agents have become a popular paradigm for interacting with open environments to facilitate AI deployment. However, hallucinations generated by LLMs - where outputs are inconsistent with facts - pose a significant challenge, undermining the credibility of intelligent agents. Only if hallucinations can be mitigated, the intelligent agents can be used in real-world without any catastrophic risk. Therefore, effective detection and mitigation of hallucinations are crucial to ensure the dependability of agents. Unfortunately, the related approaches either depend on white-box access to LLMs or fail to accurately identify hallucinations. To address the challenge posed …

Utilizing An Evidence-Based Educational Intervention To Assess Health Care Provider Knowledge And Confidence Of Weight Management Strategies In A Primary Care Setting, Fanny Ngwa Shu

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project aimed to address a clinical gap in primary care by enhancing provider and staff knowledge and confidence in delivering weight management counseling. Despite the high prevalence of overweight and obesity, many healthcare providers feel inadequately prepared to initiate weight-related discussions due to factors such as limited training, cultural barriers, and a lack of understanding of social determinants of health (SDOH) that influence patient behaviors. This gap in care can hinder the effective management of chronic conditions like diabetes, hypertension, and cardiovascular disease. The practice-focused question guiding this project was: Can an educational session …

Spartan Daily, October 21, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 25

Research Progress On The Effect Of Grafting Technology On Disease Resistance And Stress Resistance Of Watermelon, Xuena Liu, Shikai La, Chang Chen, Ainong Shi, Mingjiao Wang, Yingying Zhang, Jinghuai Guo, Lingdi Dong

Horticulture Faculty Publications and Presentations

Grafting is an effective horticultural technique that significantly enhances disease resistance and stress tolerance in watermelon. This review systematically summarizes the types of rootstocks used in watermelon grafting and analyzes the effects of grafting on plant responses to biotic stresses, such as viral and fungal pathogens, root-knot nematodes infections, and abiotic stresses, including drought, temperature extremes, and salinity. Furthermore, it discusses the changes in fruit quality and explores the underlying mechanisms associated with graft-induced resistance. By synthesizing recent research advances, this review aims to offer valuable insights and practical references for improving resistance and promoting sustainable production in cucurbit and …

Adoption Of Blockchain Technology In Beverage Supply Chains: Drivers, Benefits, And Challenges In The Coca-Cola And Bodyarmor Sport Water Recall Case, Alexander Adams Jr., Nima Molavi

Communications of the IIMA

The beverage industry faces growing scrutiny as demands for transparency and accountability intensify. In today’s digital landscape, companies must prioritize enhanced traceability to ensure product safety, comply with regulations, maintain consumer trust, and safeguard brand reputation. This research investigates blockchain technology as a potential solution to these challenges, emphasizing its capacity to decentralize data, improve traceability, and accelerate response times during safety recalls.

The study traces the evolution of food safety regulations and analyzes current traceability practices and technological innovations within the beverage sector. Using the Coca-Cola and BODYARMOR Sport Water recall as a case study, this study examines drivers, …

Leucaena - A Permanent Dry Season Forage In Australia, J H. Wildin

IGC Proceedings (1977-2023)

Leucaena (Leucaena Jeucocephala) can play an important role in alleviating the general low pasture quality during the dry season. Extensive commercial use of leucaena for cattle grazing commenced in central Queensland in 1980 when the grazing management of this tree legume was modified to suit Australian beef producers. Plantings increased from 30 ha in 1979 to 3000 ha in central Queensland by February 1985. This rapid expansion can be attributed to beef producers being more aware ofleucaena management and benefits based on several commercial successes. Mimosine toxicity has not been a problem when cattle have access to tree …

Effect Of Some Agronomic Practices On Productivity And Nutritive Analysis Of Aquatic Grass Echinochloa Stagnina, K M. Ghobrial, M A. Gabra, M A. Noreldin, M A. Salem

IGC Proceedings (1977-2023)

Results indicated that the higher green, dry and protein yields increased with increasing plant density up to 105,000 plant per feddan that were fertilized with 45 kg N/fed. The average of the obtained green, dry and protein yields were 14.16, 4.24 and 0.30 ton/fed. respectively. The nutritive analysis on DM basis was 7.13 % crude protein (CP), 2.12% ether extract (EE), 31.56% crude fidre (CF), 47.97% nitrogen free extract (NFE) and 11.22% ash. The calculated starch value (SV) as a feed unit was 1.34 ton/feddan.

The Role Of Temperature Pastures Species In Beef Farming In The Humaid Sub-Tropics Of South America, Y E. Kawabe, E Hayashi

IGC Proceedings (1977-2023)

Attempts were made to identify and solve the problems which a beef farming operation in the humid sub-tropics of South America was facing. A total of 370ha of pasture at C.A.O.S.A. was established using temperate species, Lolium perenne, L. multiflorum, Trifolium repens, T. subterraneum and Medicago sativa, both to establish new and also to improve existing tropical pasture in order to overcome: 1. Cool season feed shortage., 2. Low nutritional value of tropical grasses. A rotational grazing system was introduced and the yield and feed value analysis showed a substantial increase in cool season feed while the …

The Effect Of Row Width And Intrarow Spacing On The Productivity And Nutritional Quality Of Silage Corn, Y Kishida, S Uchida

IGC Proceedings (1977-2023)

This study was conducted to determine the effect of planting density on silage corn production and silage quality. Dent corn cv. Pioneer 3424 was planted at different or the same densities by changing row width or intrarow spacing or the both. The dry matter yield and silage quality were determined at different stages of ripening and the results are summarized as follows: When intrarow spacing was changed (under different intrarow spacings), the rate of increase of dry matter per plant was high at the low and intermediate planting densities and the dry matter yield per 10 are was high at …