Digital Commons Network^™

Automated Treatment Planning Framework For Cervical Cancer In Brachytherapy, Suman Gautam

Theses and Dissertations

Brachytherapy (BT) is a critical treatment modality for cervical cancer that delivers ionizing radiation directly to the tumor using intracavitary (IC) and/or interstitial (IS) applicators. In high dose-rate (HDR) BT, a remote afterloader guides the radioactive source to specific dwell positions for defined durations, known as dwell times, allowing for a conformal dose to the tumor while minimizing exposure to surrounding organs at risk (OAR). However, due to the inherent nature of ionizing radiation, some dose to OARs is unavoidable, creating a fundamentally conflicting objective in treatment planning: maximizing tumor coverage while minimizing OAR dose. This characterizes the problem as …

Plasmon-Assisted On-Chip Integration Of Quantum Emitter For Scalable Quantum Networking, Samprity Saha

Theses and Dissertations

In recent decades, quantum theory has sparked a revolutionary outlook on our long-standing perception of information processing and communication technologies. Photon-based quantum systems, relying on single photons governed by quantum mechanics, hold immense promise for quantum networks due to their resilience against decoherence and fast propagation speeds. However, challenges persist in realizing practical quantum networks, including the need for scalable, robust, and cost-effective quantum light. To address these challenges with classical photonic concepts, this thesis focuses on a plasmon-assisted approach for on-chip integration of single-photon sources. The study aims to develop a scalable solution for integrating quantum emitters on-chip, leveraging …

How To Touch Your Bile, Aleckxi Dorhofer

Theses and Dissertations

I have been reflecting on my past decade-long struggle with anorexia and bulimia. Reinterpreting this experience through the lenses of mythology and magic, I have constructed these Stygian carcasses (from the river Styx, which serves to separate the living and the dead) using my own bodily proportions in muslin, an intermediary material which requires transformation. In this work, I utilize these forms to symbolically rot for me as my body did, performing a type of sympathetic magic (magic worked from afar on another person) on myself, extending my life and allowing all which occurs between birth and death to affect …

Hyperreality Ain’T Really Real: Postmodernity, Social Media, & Blackness, Micah White

Theses and Dissertations

This qualitative study examines the interplay between postmodernity, social media, and African American identity formation through focus group analysis and Grounded Theory methodology. The research investigates how social media’s postmodern features—fragmentation, hyperreality, commodification, and context collapse—shape identity development among African Americans, who historically navigate cultural disruption and systemic racism. Data from semi-structured interviews with two generational focus groups revealed that participants engaged in sophisticated identity curation to balance authenticity and protection in racially charged digital spaces. Key findings highlight the tension between empowerment and marginalization, as social media served as both a platform for racial affirmation and a source of …

A Multimethod Approach To Examining Racial Coping Socialization Among Black Adolescents, Rachel J. Davis

Theses and Dissertations

Experiences of racial discrimination are pervasive in the lives of Black youth and result in race-related stress. Racial coping has been found to mitigate the negative physical and mental health effects of racial discrimination; thus, it is imperative that we understand the process that Black youth undertake to navigate racialized experiences by utilizing a person-centered approach. Additionally, parents socialize their Black youth to navigate racialized experiences, indeed, previous research has investigated racial and emotion socialization as separate phenomena, however, this does not reflect the integrated nature by which racial and emotion socialization processes are interconnected during parents’ and youths’ discussions …

A Mixed Methods Study: High School Teachers’ Perspectives On Incorporating Mindful Artmaking In Their Classroom As A Mental Health Resource, Sherry A. Bosarge

Theses and Dissertations

Mental health concerns and the need for mental health resources for high school students continue to rise in Virginia. Some of the reported benefits to the current mental health services and resources offered in Virginia schools are increased academic outcomes, attendance, and positive behaviors. The reported barriers to current mental health services and resources are lack of participation, lack of training, time constraints, funding, and resources. This explanatory sequential mixed methods study examined high school teachers’ perspectives on the benefits and barriers to incorporating mindful artmaking in their classrooms as a mental health resource at a local high school. This …

Still An Athlete? An Exploration Of Athlete Identity, Body Appreciation, And Psychological Flourishing In Middle-Aged Former Collegiate Athletes, Kelly Furr

Theses and Dissertations

Collegiate athletes, upon retirement, are encouraged to develop other interests outside of sport to form a well-rounded identity. Yet middle-aged people often struggle to complete recommended strength training and exercise guidelines, and many continue to struggle with body appreciation and psychological well-being beyond adolescence and young adulthood. Using a cross-sectional survey design, 482 former NCAA athletes completed the Athlete Identity Measurement Scale (AIMS), Exercise Identity Scale (EIS), Body-Appreciation Scale (BAS-2), and Flourishing Scale (FS). The study used Structural Equation Modeling (SEM) to determine if athlete or exercise identity positively affects body appreciation and psychological flourishing through the mediating variable of …

A Mixed Method Case Study Of Leadership For Change: Authentic Transformational Leadership In A Local Baptist Church, Hui Sun

Theses and Dissertations

This convergent parallel mixed methods case study explores how a local Baptist church navigated organizational change during and after the COVID-19 pandemic through the lens of authentic and transformational leadership. Grounded in organizational leadership and open systems framework of organizational change, the study examined two primary hypotheses: (1) RBC demonstrated an authentic transformational leadership paradigm in its change processes since 2020, and (2) this paradigm significantly and positively influenced perceived leadership effectiveness.

Qualitative data were collected through semi-structured interviews with six leaders (three pastors, one minister, one staff leader, and one deacon) and 11 raters (five lay leaders, five congregants, …

Using Habituation And Affective Forecasting To Distinguish When The Passive Enjoyment Of Harm Begets The Active Pursuit Of Aggression, Drew M. Parton

Theses and Dissertations

Understanding the antecedents and impellers of aggression is key to preventing violence, and individual differences have been identified as some of the key factors of interest in the study of aggression. Antisocial personality traits such as psychopathy, Machiavellianism, Narcissism, and Sadism have received considerable focus from researchers. Among these traits, Sadism stands above them all as arguably the most malevolent of all trait constructs in psychology. Sadism shows the strongest correlations with aggression among malevolent traits and is uniquely linked to unprovoked aggression, even when it is costly. Sadism thus represents an extreme risk factor for aggression, and studying its …

Facile Synthesis Of Gold, Copper, And Silicon Nanostructures By Laser Ablation In Liquid, Nicholas Simpson

Theses and Dissertations

Metal nanoparticle (NP) synthesis is a continually evolving area of research, owing to the widespread application of NPs in fields such as catalysis, drug delivery, and biosensing. Compared to bulk metal material, NPs contain a larger proportion of surface atoms and exhibit unique optical properties, thus making them ideal for applications where maximizing surface interactions is key. Moreover, their compositions can be altered in several different ways, as evidenced by metal alloy, core/shell, supported, and defective NPs. While conventional synthesis methods are capable of producing NPs in large quantities, they often require conditions of high temperature and pressure, strong reducing …

Therapy-Induced Senescence In Cancer: Developing Senolytic-Based Combination Strategies To Delay Re-Emergence Of Triple-Negative Breast Cancer, Eesha Chakraborty

Theses and Dissertations

Therapy-induce senescence (TIS) represents a major biological outcome of many anticancer treatments and is increasingly recognized as a strategic vulnerability in triple negative breast cancer, which is a highly aggressive subtype with limited therapeutic options and frequent relapse. Here, we probed TIS as a primary cellular response that may ultimately compromise long-term outcomes using standard chemotherapeutic agents in TNBC as well as the antibody-drug conjugate sacituzumab govitecan (SG). Both chemotherapy and SG reliably induced pronounced senescence across TNBC models, yielding durable growth arrest, however, also generating a persistent reservoir of viable tumor cells capable of eventual proliferative recovery, a hallmark …

Exploring The Role Of Host Immune Responses And Bacterial Sensory Pathways In The Development Of Treponema Denticola-Mediated Periodontal Disease, Annie N. Hinson

Theses and Dissertations

Periodontitis is a chronic inflammatory disease driven by dysbiotic microbial communities and maladaptive host responses. Treponema denticola, a spirochete pathobiont, is strongly associated with disease severity. However, the molecular mechanisms underlying its interaction with host tissues and regulation of virulence remain incompletely understood. This work examines both the epithelial immune responses and bacterial transduction systems that shape T. denticola pathogenesis. Transcriptomic analysis of gingival keratinocytes revealed IL-36γ as the most highly induced cytokine following infection with T. denticola. Functional studies demonstrated that IL-36γ induction occurs in a dose- and time-dependent manner through TLR2/6 signaling, requiring the NF-κB, PI3K/Akt, and …

Identity Formation Of A Pre-Service Art Educator: An Arts-Based Approach To Data Visualization As A Means Of Understanding Personal Experience, Kelsey L. Peterson Mays

Theses and Dissertations

This research centers on the emotional experience of the author as a pre-service art educator during her student teaching semester. The research utilized art-based data collection methods and analyzed both written and visual reflections over an eight-week period of teaching art at the elementary school level. The culmination of findings is synthesized in the form of a body of four visual artworks, where each work reflects the data collected over a consecutive period of two weeks. The study investigated the causation and ramifications of certain emotions during a transitional time wherein the author existed in a liminal space between student …

Characterization Of Outer Surface Protein C Of Borreliella Role In Host Tropism, Kathryn Mf Chambers

Theses and Dissertations

The Lyme disease spirochetes, Borreliella spp., are maintained in nature through a complex enzootic cycle involving Ixodes ticks and a diverse set of reservoir hosts. The outer surface protein C (OspC) of the bacterium is an essential virulence factor required for transmission from ticks and early infection of mammals. Deletion of ospC abolishes infectivity, yet the precise molecular mechanisms underlying OspC function remain incompletely defined. In this dissertation, I examined the contribution of OspC type identity to host specificity. OspC is highly diverse, with over 30 genetically stable types described. While intra-type sequences are conserved (>95% amino acid …

Dickkopf1(Dkk1): A Novel Endogenous Ligand To Prime Nlrp3 Inflammasome Via Tlr4, Theingi Aung

Theses and Dissertations

Dickkopf1(DKK1) is a quintessential Wnt antagonist and immunomodulator in various inflammatory diseases. The underlying molecular mechanisms of DKK1-mediated immunomodulation remain elusive. Here, we identified TLR4 as a new receptor for DKK1 to activate NFκΒ pathway-mediated gene expression and pyroptosis via NLRP3 inflammasome in human and mouse macrophages.

DKK1 employed TLR4 to initiate NFκB signaling cascade via MyD88. MyD88-TAK1-NFκΒ pathway activation by DKK1 increased HIF1α, NFκB, and NLRP3 protein expression levels, leading to pyroptosis. Unlike LPS, DKK1 did not induce IRAK4 phosphorylation, while the interaction between MyD88 and IRAK4 was maintained for downstream signaling activation. DKK1 did not induce IRF3 phosphorylation …

Beliefs Related To Diagnosing Bpd And Complex Ptsd, Bailey Pascuzzi

Theses and Dissertations

There has been speculation that Borderline personality disorder (BPD) and Complex post-traumatic stress disorder (Complex PTSD) are the same disorder or represent separate disorders on a broader trauma spectrum (Frost et al., 2020; Lewis & Grenyer, 2009). BPD and Complex PTSD share several symptoms but differ in their presentation (Ford & Courtis, 2021). Because the two disorders present so similarly, it could be that clinicians have difficulty differentiating them, leading to misdiagnosis (Miller, 2014). This study examined clinicians’ diagnostic decision-making and stigma toward BPD and Complex PTSD. Participants (N = 426) completed an online survey where they diagnosed a written …

“Some Vague Utopia”: Searching For Urania, Moira L. Neve

Theses and Dissertations

Despite the global pendulum swing of gender trouble marked by the United States’ President’s declaration that there are only two sexes, activists have been rejecting assimilation (ie. defining equality as gay marriage or queer people in the military) within queer studies long before 2025. In the first half of the 20th century, a journal by the name of Urania (1916-1940), privately published and circulated to their home base in the United Kingdom and beyond, five editors (Esther Roper, Eva Gore-Booth, Jessey Wade, Dorothy Cornish, and Irene Clyde/Thomas Baty), challenged the gender binary and the resulting assumptions of heterosexual marriage. This …

(Art) Education In The Afterlife Of Massive Resistance: Constructing, Capturing, And Commodifying Racialized Disability In Virginia’S Student Assignment Practices, 1956-1966 And Present Day, Jenna E. Gabriel

Theses and Dissertations

This dissertation explores discursive functions of disability in pupil placement decisions in Massive Resistance Virginia, the relationship between disability and race that was constructed through these moves, and how these relationships surface in the reflections, perceptions, and pedagogy of a practicing art teacher, Nathan, who works at Arts High School (AHS), a Virginia specialty center high school. Under the umbrella of the Discourse Historical Approach, which relies on multiple, interdisciplinary data sources to explore how discourses evolve, I connect a robust archival analysis of historical data collected in the records of Virginia’s Pupil Placement Board (746 boxes, 1956-1966) with present-day …

Liner Notes On Black Trans Girlhood: Afrofuturist Affect & Black Popular Music As A Praxis Of Self-Fashioning, Shawn J. Williams

Theses and Dissertations

Liner Notes on Black Trans Girlhood: Afrofuturist Affect & Black Popular Music as a Praxis of Self-Fashioning interprets Black musical performance in identity-making, with a focus on how music and Black trans identity intersect and informs Black trans girlhood. As such, Black trans girls render ourselves legible, i.e. understood without shame or judgment, by constructing our identities through the music by Black women we listen and dance to, or watch and sing. These musical connections affirm the possibilities of Black femme expression. This expression of Black femininity is due to what I call an Afrofuturist affect, by which I refer …

Molecular Mechanisms Of Kynurenine-Mediated Lifespan Regulation In Yeast, Ryan E. Counterman Jobb

Theses and Dissertations

The kynurenine pathway is a highly conserved pathway that acts as the primary pathway for tryptophan catabolism and has been found to be involved in lifespan regulation across many diverse organisms. Caloric restriction (CR) is the only known dietary intervention to date that both increases the mean lifespan and the health span of multiple organisms, although the molecular mechanisms of these effects are not fully understood. There are known and sometimes contradictory relationships between the kynurenine pathway activity and the life- extending effect of CR but the crosstalk between the two is not well characterized. Understanding these relationships could lead …

Reverse Geometric Dispersion In The Beaufort Sea: Dissecting Sound Propagation At Long Ranges In Ducted Profiles, Jessica Desrochers

Open Access Dissertations

Acoustic propagation in the Arctic is evolving as surface temperatures increase and ice melts, resulting in a changing sound propagation environment. This study investigates the acoustic arrival structure in the Canada Basin and its connection to the underlying sound speed profiles. Two Seagliders were deployed in the summer of 2016 and 2017, diving in a sawtooth pattern collecting conductivity, temperature, and depth (CTD) data as part of the Canada Basin Acoustic Glider Experiment (CABAGE). These data are used to calculate sound speed profiles used to predict and understand acoustic arrival structures.

The warming of the Pacific Summer Water and surface …

Rethinking Behavior - Winter 2025, Midwest Symposium For Leadership In Behavior Disorders

ReThinking Behavior Magazine

A magazine for professionals serving children and youth with behavioral needs.

Winter 2025, Volume 8, Issue 2

United States Environmental Protection Agency Scientific Integrity Policy

Copyright, Fair Use, Scholarly Communication, etc.

US EPA SIP

Subcontracted Detention Centers: Potential Oversights In Migrant Detention Regulation And Human Rights Enforcement, Caia Marcee

Undergraduate Student Research Awards

No abstract provided.

New Threats To Campus Protest, Timothy Zick

Faculty Publications

This symposium Essay focuses on how universities responded, both initially and after the fact, to campus protests concerning the Hamas-Israel War. During those protests students and others erected encampments, held demonstrations, displayed signs, vandalized university property, and occupied buildings. Some protesters communicated anti-Semitic tropes and slogans. Although a few university leaders responded to the protests by negotiating with protest leaders, most relied on law enforcement and security to clear encampments and restore order. Since the initial protests, universities have adopted a spate of new policies that threaten campus protest. These measures include cancellation of already-permitted demonstrations, content-based speech restrictions, bans …

Restructuring Ruritania: Bankruptcy, Sovereign Debt, And The Equity Receivership, Nathan B. Oman

Faculty Publications

The traditional legal story of sovereign restructuring goes something like this: foreign governments cannot file for bankruptcy under domestic law. When faced with the need to restructure unsustainable debts, they must negotiate with each of their creditors. Since the late 1980s, private debt has been held by increasingly diverse and dispersed bondholders, making renegotiation more difficult. Defaulting debtors face two basic problems: first, they have no process analogous to the automatic stay in bankruptcy, which can pause litigation by creditors and buy time for an orderly reorganization; second, and more importantly, they have no process analogous to the cramdown provisions …

By Any Other Name: Dei Is Not What You Think It Is, Nicole Porter

Faculty Publications

In this moment, Diversity, Equity, and Inclusion (DEI) programs are hotly debated and very misunderstood. Contrary to popular belief, DEI programs do not drastically change an employer’s hiring practices. They are, to some extent, performative. In this essay, I explain what DEI really is and why a rebranding (or at least a new name) might be in order.

Hypnosis And Mindfulness Audio Recordings For Reducing Fatigue In Individuals With Multiple Sclerosis: A Randomized Controlled Study, Mark P. Jensen, Susan Robles, Michael G. Nash, Susanne May, Dwan M. Ehde, Melissa A. Day, Owen Gottlieb, Laurence I. Sugarman, Kevin N. Alschuler

Articles

Background

Fatigue is a common problem in individuals with multiple sclerosis (MS).

Objective

The objective was to evaluate the effects on fatigue of having 4 weeks of

access to audio recordings of therapeutic hypnosis (HYP) and mindfulness meditation

(MM) practices.

Methods

A total of 333 individuals with MS and fatigue were randomly assigned to

one of the three treatment conditions for 28 weeks: (1) access to therapeutic HYP audio

recordings, (2) access to MM audio recordings, or (3) no access to recordings

(treatment as usual or TAU). Fatigue impact (primary outcome) and other outcomes

were assessed at 4, 16, and …

Mirabile Dictu: The Bryn Mawr College Library Newsletter 28 (2025), Bryn Mawr College Library

Mirabile Dictu: Newsletter of the Bryn Mawr College Libraries

No abstract provided.

Identification Of Benzothiophene-Derived Inhibitors Of Flaviviruses By Targeting Rna-Dependent Rna Polymerase, Leah Liu Wang, Shazeed-Ul Karim, Aidan Hand, Ryan Brunkhorst, Mackenna Petersen, Sarah Altam, Yi Liu, Luwen Zhang, Fengwei Bai, Shi-Hua Xiang

School of Biological Sciences: Faculty Publications

Flaviviruses such as Dengue, West Nile, and Zika viruses are mosquito-borne RNA viruses that can cause serious diseases in humans. To develop effective drugs for treating these viruses’ infections, we create a new approach for developing common or shared drugs that may work for several different viral species of flaviviruses. It is based on the conserved RNA-dependent RNA polymerase (RdRp), which is the key enzyme for viral replication. We built up a common structure of RdRps (POLcon) from their consensus sequence. A conserved Triple-D structural motif was identified at the active site of POLcon that has been used for virtual …