Digital Commons Network^™

Meeting Highlights The 4th Marie Skłodowska-Curie Symposium On Cancer Research And Care: Mechanisms Of Support For Regional & International Collaborations, Pawel Kalinski, Kathleen M Kokolus, Indu Ahluwalia, Mihaela Balu, Łukasz Balwicki, Brygida Baran, Loretta Beine, Mikhail Berezin, Ioana Berindan-Neagoe, Andriy Beznosenko, Blanka Borowiec, Szabolcs Bozsányi, Jonathan Bramson, Brian Czerniecki, Rūta Everatt, Wojciech Fendler, Peter Forsyth, Jeffrey E Gershenwald, Maciej Goniewicz, Khurshid Guru, Andrew Hyland, Smitha James, Iva Kirac, Pawel Koczkodaj, Leszek Kotula, Maciej Łuba, Iwona Ługowska, Elizabeth Luke, Cristian Lungulescu, Sandro Matosevic, Kaushal Nanavati, Michael Nemeth, Karolina Nowak, Katia Noyes, Mark Parascandola, Waldemar Priebe, Piotr Rutkowski, Mukund Seshadri, Christine E Sheffer, Ioana-Miruna Stanciu, Joanna Stanson, Telisa Stewart, Edita Sužiedėlienė, Kęstutis Sužiedėlis, Iryna Tanasiichuk, Anda M Vlad, Wei-Zen Wei, Dylan Williams, Malgorzata Wojtowicz, Tomasz Zdrojewski

Faculty, Staff and Student Publications

The Marie Skłodowska-Curie Symposia on Cancer Research and Care (MSCS-CRC) promote collaborations between cancer researchers and care providers in the United States, Canada and Central and Eastern European Countries (CEEC) to accelerate the development of new cancer therapies, new strategies for early detection and prevention, and improve cancer care and the quality of life for patients and their families. The 4th MSCS-CRC (September 25-27, 2024, Buffalo, New York) brought together 147 participants from the US, Canada, Croatia, Czechia, Lithuania, Poland, Romania and Ukraine, and involved representatives of the US Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI) …

Comparison Of Deep Learning Schemes In Grading Non-Alcoholic Fatty Liver Disease Using B-Mode Ultrasound Hepatorenal Window Images With Liver Biopsy As The Gold Standard, Petros Drazinos, Ilias Gatos, Paraskevi F Katsakiori, Stavros Tsantis, Efstratios Syrmas, Stavros Spiliopoulos, Dimitris Karnabatidis, Ioannis Theotokas, Pavlos Zoumpoulis, John D Hazle, George C Kagadis

Faculty, Staff and Student Publications

Background/introduction: To evaluate the performance of pre-trained deep learning schemes (DLS) in hepatic steatosis (HS) grading of Non-Alcoholic Fatty Liver Disease (NAFLD) patients, using as input B-mode US images containing right kidney (RK) cortex and liver parenchyma (LP) areas indicated by an expert radiologist.

Methods: A total of 112 consecutively enrolled, biopsy-validated NAFLD patients underwent a regular abdominal B-mode US examination. For each patient, a radiologist obtained a B-mode US image containing RK cortex and LP and marked a point between the RK and LP, around which a window was automatically cropped. The cropped image dataset was augmented using up-sampling, …

Cord Blood-Derived Ink T Cells As A Platform For Allogeneic Car T Cell Therapy, Maison Grefe, Abel Trujillo-Ocampo, Jelita Clinton, Hong He, Ling Yu, Dan Li, Qing Ma, Elizabeth J Shpall, Jeffrey J Molldrem, Jin S Im

Faculty, Staff and Student Publications

CD1d-restricted invariant Natural Killer (iNK) T cells are a suitable candidate for allogeneic Chimeric Antigen Receptor (CAR) T cell therapy as they do not cause graft-versus-host disease (GvHD) due to the monomorphic nature of CD1d proteins. However, the phenotypic and functional heterogeneity of iNK T cells from adult donors (AD) may lead to the inconstant CAR-iNK T cell products. Cord blood-derived (CB) iNK T cells, in contrast, exhibit inter-donor homogeneity in phenotype including uniform CD4 expression and are enriched in memory iNK T cell populations. Thus, we evaluated the preclinical therapeutic potential of iNK T cells derived from cord blood …

Stat3 Inhibition In Combination With Cd47 Blockade Inhibits Osteosarcoma Lung Metastasis, Pradeep Shrestha, Rejeena Shrestha, You Zhou, Rafal Zielinski, Waldemar Priebe, Eugenie S Kleinerman

Faculty, Staff and Student Publications

Background: New therapies are urgently needed for patients with osteosarcoma (OS). STAT3 and CD47 are potential therapeutic target in OS. Here we investigated the therapeutic activity of the orally bioavailable STAT3 inhibitor, WP1066, and anti-CD47 antibody using OS mouse models.

Methods: Cytotoxic effect of WP1066 against OS cell lines and its immunomodulatory effects were evaluated in vitro. Experimental metastasis and orthotopic syngeneic mouse models were used to investigate the therapeutic efficacy of WP1066 and anti-CD47 antibody. Further flow cytometric analysis was performed.

Results: STAT3 was constitutively activated in multiple human and mouse OS cell lines. WP1066 suppressed STAT3 activation …

Evaluation Of Quantum Contouring Algorithms For Treatment Planning On Mr Abdominal Images, Rachel Glenn, Tucker Netherton, Adrian Celaya, Mohamed Eltaher, Beatrice Riviere, Eugene J Koay, David Fuentes

Faculty, Staff and Student Publications

Introduction: Quantum computing is increasingly being investigated for integration into medical radiology and healthcare applications worldwide. Given its potential to enhance clinical care and medical research, there is growing interest in evaluating its practical applications in clinical workflows.

Methods: We developed an evaluation of quantum computing-based auto-contouring methods to introduce medical physicists to this emerging technology. We implemented existing quantum algorithms as prototypes tailored for specific quantum hardware, focusing on their application to auto-contouring in medical imaging. The evaluation was performed using a medical resonance imaging (MRI) abdominal dataset, comprising 102 patient scans.

Results: The quantum algorithms were applied to …

Predicting Sinonasal Inverted Papilloma Attachment Using Machine Learning: Current Lessons And Future Directions, Sean P Mckee, Xiaomin Liang, William C Yao, Brady Anderson, Jumah G Ahmad, David Z Allen, Salman Hasan, Andy J Chua, Chinmay Mokashi, Samia Islam, Amber U Luong, Martin J Citardi, Luca Giancardo

Faculty, Staff and Student Publications

Background: Hyperostosis is a common radiographic feature of inverted papilloma (IP) tumor origin on computed tomography (CT). Herein, we developed a machine learning (ML) model capable of analyzing CT images and identifying IP attachment sites.

Methods: A retrospective review of patients treated for IP at our institution was performed. The tumor attachment site was manually segmented on CT scans by the operating surgeon. We used a nnU-Net model, a state-of-the-art deep learning-based segmentation algorithm that automatically configures image preprocessing, network architecture, training, and post-processing to identify the IP attachment site. The model was trained and evaluated using a 5-fold cross …

Current Practices In Implementing The Occupational Therapy Doctoral Capstone Needs Assessment: A National Survey, Laurie D. Stelter, Kaitlyn Cremer, Lou Rutigliano, Leslye Morris, Lima Ghulmi, Ana Allegretti

Occupational Therapy Faculty Publications

Entry-level occupational therapy doctorate (OTD) programs navigate curricular decisions related to designing, implementing, and refining doctoral capstone processes. One of the complex requirements is the doctoral capstone needs assessment (DCNA) which each student completes prior to the implementation of the doctoral capstone project. The researchers aimed to contribute to the specificity of DCNA-related understanding, informing quality decision-making, via a national, cross-sectional survey of current DCNA practices. Purposive sampling resulted in a 24.3% (n=54) response rate of mostly Doctoral Capstone Coordinators (DCCs; 98.1%) representing programs across doctoral capstone experience levels. The timing of DCNA processes trended toward the latter half of …

Is Laughter The Best Medicine? Analyzing The Role Of Gallows Humor In Nursing Education, Favour Onichabor-Connell

Honors College Theses

Gallows humor is a coping mechanism used by healthcare professionals to manage stress and emotional burden. Understanding its role in nursing education can help educators and students navigate the complexities of the profession. This study examined its significance through a literature review and a survey of nursing students and educators. The literature review included 15 peer-reviewed articles from databases like GALILEO, CINAHL, PubMed, and Scopus, highlighting both its benefits and ethical concerns. Findings suggest gallows humor is commonly used for stress management and is generally viewed as beneficial for learning and emotional resilience. However, concerns were raised about its potential …

Analysis Of The Microbiome Of Amblyomma Americanum In The Statesboro Region, Ella Zierdt, Lorenza Beati, Mary Humphrey, Saviour Dralabu

Honors College Theses

The lone star tick, Amblyomma americanum, is the most common tick in Georgia. It is mainly known as an Ehrlichia spp. vector, but its microbiome can be diverse, depending on geography, developmental stage, and season. Little is known about bacterial diversity in ticks from the southeastern U.S. A Nanopore MinION sequencer was used for a preliminary analysis of the bacterial microbiome in A. americanum from the Statesboro region. DNA was extracted from 39 nymphs, 35 males, and 39 females. DNA samples were pooled by month of collection and life stage/sex, amplified with barcoded 16SrDNA primers, and sequenced. Approx. 77% …

Embodied Mythology Of Rhetoric: The Dialectic Of The Gender Binary Logos, Isaac A. Lacap

Honors College Theses

Gender is often described as a social construct. This description usually contrasts social construction with other unchanging, unambiguous concepts. Through Chiara Bottici's analysis, I argue the concept of myth breaks us from this dichotomy. By understanding myth as the persistent creation of significance through narratives, we no longer leave myth to the ambit of untruth and unreality. Instead, we see myths as a way to direct people’s actions by giving them a way to see the world. By integrating Bottici with Merleau-Ponty's phenomenology, I argue the significance of myth occurs through embodiment by organizing gestures. These gestures form a system …

Comparing The Patient Shielding Practices For Healthcare Facilities In Southeast Georgia, Genesis Horton

Honors College Theses

Since the discovery of X-rays in 1895, research has consistently been conducted on their capabilities and limitations in healthcare. One primary focus of interest is patient shielding, especially regarding radiation protection and patient safety. Introduced in the mid-1900s, patient shielding has been practiced to protect the gonads, the thyroid, and other radiosensitive body parts. This research project investigated common shielding protocols implemented in healthcare facilities, specifically within Southeast Georgia. This study utilized anonymized in-person interviews with local imaging departments regarding their procedures and protocols for patient shielding. Results from these interviews have been analyzed and compared to shielding best practices …

Are Blow Flies (Diptera: Calliphoridae) Active Nocturnally In South Georgia?, Breana R. Manning

Honors College Theses

Medicolegal forensic entomology uses insect colonization of remains to estimate minimum post-mortem intervals (mPMI). Blow flies (Diptera: Calliphoridae) are among the earliest colonizers, yet their nocturnal activity remains poorly understood. This study aimed to determine whether blow flies are active at night and whether artificial light influences their behavior. Using baited bottle traps in both artificially lit and unlit environments near Georgia Southern University, flies were collected over two trials in fall 2024. Of the 1,843 blow flies collected, only six were captured at night (0.003%), suggesting minimal nocturnal activity. Lucilia coeruleiviridis preferred unlit environments. In contrast, Cochliomyia macellaria was …

Exploring Anterior Cruciate Ligament Tears: Causes, Reconstruction, And Outcomes, Holly L. Bollinger

Honors College Theses

The anterior cruciate ligament (ACL) is a critical structure in knee stability, and its injury can significantly impair athletic performance and daily functionality. The ACL plays a vital role in stabilizing the knee joint, preventing excessive forward movement of the tibia relative to the femur and aiding in rotational control. ACL tears are commonly associated with sports and physical activities that involve sudden stops, pivots, or changes in direction. These injuries can lead to knee instability, impaired function, and long-term complications. Despite the prevalence of ACL tears, there remains a lack of consensus on the multifactorial causes, optimal reconstruction techniques, …

Ankle Dorsiflexion Range Of Motion And Its Association With Semi-Professional Female Soccer Player's Overall Performance, Lily G. Nolan

Honors College Theses

Lower extremity injury screening is a common tool in soccer due to the changes of direction, jumping, landing, and cutting maneuvers players must exhibit. Talocrural dorsiflexion range of motion (DFROM), vertical jump (VJ) and unilateral hop tests are used to assess ankle and knee injury risk. Further, DFROM asymmetries may present a higher risk than reduced DFROM alone. It is unknown how DFROM asymmetries affect these tests. Thus, the purpose of this study was to examine the relationship between DFROM and hop and VJ performance, and to examine the differences between those with and without DFROM asymmetries. The current results …

English Language Learners In The Classroom: Perspectives And Teaching Approaches Using Art Integration, Kimberly M. Rodriguez

Honors College Theses

Art is a sensory language. In language learning, visual literacy is an essential factor in developing interlanguage. Art can interchange cultural understanding and promote social learning. The research gathered is based on the perspectives of teachers in the neighboring schools located in Georgia. The purpose of this paper is to examine how teachers can support language learning using visual literacy. Teachers are asked to participate in an interview to record their experiences in language learning. In the completion of the data collected, the analysis gives a deeper understanding of how to improve accommodating language learners in the classroom using visual …

Impact Of Expert Witness Gendered Appearance And Emotion On Perceptions Of Credibility And Verdicts, Audrey Molter

Honors College Theses

Past research has highlighted biases in how individuals are perceived based on their gender and expressed emotions. The current study assessed how the perceived femininity or masculinity of expert witnesses impact credibility and verdicts in a jury decision making task. Additionally, it investigated how the presence or absence of emotional expression, specifically, anger versus neutral presentations, affects the perception of expert credibility and verdict outcomes. One hundred and eighteen undergraduate participants assumed the role of jurors in a criminal trial involving ambiguous evidence, with the expert witness serving as the primary source of testimony for the defense. Four versions of …

Exploring The Effects Of Resource Salience On Perceptions Of Social Support And Belongingness In Undergraduate Students, Arya C. Johnson, Karen Z. Naufel

Honors College Theses

In recent years, mental health has been a rising concern among college students (Worsley et al., 2022). One method to mitigate stress and raise levels of mental health is social support, which is support derived from relationships or the environment (Zee & Bolger, 2019). Social support presents in different forms, such as visible social support, or support directly given to and acknowledged by the recipient, and invisible social support, or support indirectly given to and unacknowledged by the recipient. Another method to mitigate stress is belongingness, which is the feeling that one is an intrinsic part of their environment (Hagerty …

The Role Of Horizontal Gene Transfer In Antibiotic Resistance Amidst Prevalent Community And Healthcare-Associated Mrsa Rates, Gabrielle Nascimento

Honors College Theses

In recent decades, cases of community-acquired MRSA (CA-MRSA) and healthcare-associated MRSA (HA-MRSA) have been on the rise. The ability of antibiotic resistance to transfer between microorganisms greatly expands its threat to the effective treatment and containment of bacterial infections. The mecA gene is found on a mobile cassette within the Staphylococcal cell and encodes for PBP2a, an alternate version of penicillin-binding protein (PBP) with less binding affinity for β-lactam antibiotics, increasing resistance to the effects of antibiotics. The goal of this research is to investigate the horizontal transfer of the mecA gene between various Staphylococcus species as well as to …

Exploring Lgbtq+ Competency In Healthcare, Jordan Whiteman

Honors College Theses

Marginalized groups such as the LGBTQ+ community are known to face healthcare disparities that negatively affect their process of navigating healthcare systems. This project explores the perceived lack of representation and understanding of the LGBTQ+ community within healthcare settings, exposing the deficits in knowledge for unique challenges and inequalities these patients may face. By viewing the literature, a myriad of complications faced by LGBTQ+ people in clinical settings can be identified. They possess a generalized feeling of mistrust towards the healthcare system. Healthcare staff overall describe low confidence with caring for this demographic. Heteronormativity’s presence in the field of healthcare …

I Prophesy Disaster: Adapting Musical Storytelling To Fashion, Adam Snedden

Honors College Theses

Fashion is an artistic medium, where garments communicate ideas to any potential viewers by using visual imagery and relying on our cultural expectations. At the level of haute couture design, these visuals grow more elaborate and dramatic. With this project, I wanted to accomplish the goal of adapting a song, the gothic-inspired progressive rock epic A Plague of Lighthouse Keepers, into a single couture-style look. Getting as many details of the song as possible to be apparent in an overcoat, shirt, and pants was a challenging task that required extensive use of embroidery and attention to detail. Additionally, this look …

Evaluation Of Therapist Modeling To Decrease Latency To Exercise Initiation, Darci L. Davis, Kayla Randall

Honors College Theses

Patients recovering from traumatic brain injury (TBI) or other adverse health events (e.g., hip surgery) often require physical therapy (PT) to restore baseline function. However, individuals with mild cognitive impairment (MCI) or dementia may have difficulty engaging in therapy due to deficits in attention, imitation skills, and motor performance. Enhancing participation in this population is essential for achieving functional recovery and return to baseline status. This study aimed to determine whether systematic model prompting could decrease latency to compliance and increase the level of completion of therapeutic exercises in short-term rehabilitation settings. A multiple-baseline single-case design with time-lagged and staggered …

Puzzling Our Way Into Computational Thinking, David J. Mulder

Faculty Work Comprehensive List

This unplugged activity is a brief, practical introduction to computational thinking that uses an accessible and decidedly low-tech approach: solving a jigsaw puzzle. The skills needed to collaboratively solve a jigsaw puzzle illustrate the key concepts of computational thinking in a straightforward way that makes the basics of decomposition, pattern recognition, abstraction, and algorithmic thinking come to life. The learning representation included here was taught as part of a professional development workshop for PK-12 teachers but could easily be adapted to use with learners from upper elementary grades through middle school, high school, or university.

Navigating The Growing Prospects And Growing Pains Of Managed Aquifer Recharge, Dave Owen, Helen Dahlke, Andrew Fisher, Ellen Bruno, Michael Kiparsky

Faculty Scholarship

Increasing water demands and declining groundwater levels have led to rising interest in managed aquifer recharge. That interest is growing in the United States—the focus of this article—and elsewhere. Increasing interest makes sense; managed aquifer recharge can reduce water-supply challenges and provide environmental benefits, sometimes with lower costs than alternative water-management approaches. But managed aquifer recharge also faces growing pains, which will make it difficult for projects to scale up and may limit the benefits provided by those projects that do go forward. Some of the problems arise from the challenges of finding physically suitable locations for managed aquifer recharge; …

Minimax Under Pressure: The Case Of Tennis, Ben Depoorter, Simon Jantschgi, Ivan Lendl, Miha Mlakar, Heinrich N. Nax

Faculty Scholarship

A series of articles has tested von Neumann’s minimax theory against behavioral evidence based on field data from professional sports. The evidence has been viewed and collectively cited as positive evidence that elite athletes in their familiar sports contexts mix well and behave in line with minimax. In this paper, based on open state-of-the-art tennis data and analytics, we shall uncover new and significant evidence against minimax at the very top of the game, where previously, such results had not been obtained. The kinds of behavioral deviations from minimax that we find become apparent, because we enrich the test strategy …

Legislatively Erased: The Failure Of Privacy Legislation To Protect People Connected To The Criminal Legal System, Kate Weisburd, Chaz Arnett

Faculty Scholarship

No abstract provided.

The Ninth Circuit’S Nod To Anti-Vaccine Advocates, Richard H. Hughes Iv, Dorit R. Reiss

Faculty Scholarship

On June 7, 2024, a three-judge panel of the Ninth Circuit issued a decision that, while it did not go as far as anti-vaccine activists claimed, clearly drew on anti-vaccine tropes, and suggested a retreat from important public health precedents.

This Article explains the decision and the way in which it can undermine public health law. In short, the decision is problematic in two ways. First, it accepts claims that are untrue on their face. By ignoring the evidence and facts provided by public health authorities and experts, the opinion demonstrates further erosion of the high deference to expertise embodied …

Cdc As A Debunker: The Limits Of Government In Countering Misinformation, Dorit R. Reiss

Faculty Scholarship

This Article argues that even in the best of times, government agencies are not well suited to debunking misinformation and suggests as alternatives a role for government in providing accurate information, a potential role for government in providing grants for debunking, and a more central role for private institutions in supporting debunking. It uses, as a case study, the Centers for Disease Control and Prevention (CDC)’s response to vaccine misinformation, focusing on issues the CDC has been addressing since before the COVID-19 pandemic, to highlight that the problem goes beyond the challenges of responding fast and accurately to the uncertainties …

Taking The Name Brown In Vain: Separate But Equal, Brown And The Harvard Case, Matthew Coles

Faculty Scholarship

Bad history in legal opinions is understandable, if most of the time not excusable. Bad legal analysis in Supreme Court opinions is not. Judges are not trained historians. They are trained lawyers. They should know how to do law. This essay is about bad lawyering at the Court. Specifically, this essay is about the shoddy misuse of Brown v. Board of Education, the canonical case in which the Supreme Court finally began to use the 14th Amendment to protect Black people, in Students for Fair Admissions v. Harvard.

Water And The Western City, Dave Owen

Faculty Scholarship

No abstract provided.

A Decolonial And Liberation Lens To Social Justice Research: Upholding Promises For Diverse, Inclusive, And Equitable Psychological Science, Luz M. Garcini, Aldo Barrita, German Cadenas, Melanie M. Domenech Rodriguez, Thania Galvan, Alfonso Mercado, Oswaldo Moreno, Manuel Paris, Oscar F. Rojas Perez, Michelle Silva, Amanda Venta

Psychological Science Faculty Publications

In the face of harmful disparities and inequities, it is crucial for researchers to critically reflect on methodologies and research practices that can dismantle systems of oppression, accommodate pluralistic realities, and facilitate opportunities for all communities to thrive. Historically, knowledge production for the sciences has followed a colonial and colonizing approach that continues to silence and decontextualize the lived experiences of people of color. This article acknowledges the harm to people of color communities in the name of research and draws from decolonial and liberation frameworks to advance research practices and psychological science toward equity and social justice. In this …