Digital Commons Network^™

A Neutrostructural Framework For Coordinated Development Evaluation Of Land Resource Utilization And Ecological Environmental Protection, Qian Luan

Neutrosophic Sets and Systems

No abstract provided.

Hybrid Physical Education Teaching Process In Colleges: A Performance Evaluation Perspective Using The Single Valued Bipolar Pentapartitioned Neutrosophic Set, Guifang Shen

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets And Systems, Vol. 87,2025, Florentin Smarandache, Mohamed Abdel-Basset, Maikel. Leyva Vazquez

Neutrosophic Sets and Systems

No abstract provided.

Uncovering The Works By Early Modern Women Printers: An Experiment With Generative Ai, Tang (Cindy) Tian, Daniela Rovida

Journal Articles

The contributions of women to the printing trade during the hand press era have long been under- documented, leaving significant historical gaps in our understanding of early print culture. This article presents a project that uses ChatGPT-4o, a generative artificial intelligence (AI) chatbot, to help bridge those gaps by identifying, analyzing, and contextualizing the work of women printers represented in the University of Notre Dame’s rare book collections.

Front Lines: Developing A Military Medicine Honors Track, Bryan G. Beutel

Faculty and Staff Publications

No abstract provided.

Corneal Pseudomicrocysts Following Claudin-6 Antibody-Drug Conjugate Infusion, Laura Matuszewska, Caitlynn Cooper, Victoria Sattarova, Wassef Chanbour, Evan Meyer, Vania Rashidi

Student Publications

Purpose

To report a case of bilateral corneal pseudomicrocysts associated with infusions of a novel antibody-drug conjugate targeting claudin-6, called TORL-1-23.

Observations

A 47-year-old female with a history of advanced recurrent serous ovarian cancer presented to a level 1 tertiary care center with ocular irritation, redness, tearing, and light sensitivity following two infusions of TORL-1-23. Patient's past ocular history was unremarkable. The patient was enrolled in a phase 1 clinical trial for TORL-1-23, an antibody-drug conjugate (ADC). Nine days following the second infusion the patient presented to the ophthalmology clinic complaining of two weeks of bilateral eye discomfort, tearing, and …

Mucinous Cystic Neoplasms Of The Pancreas And Liver Share A Similar Dna Methylation Profile With Mucinous Ovarian Tumors, Zoe Leoni, Teodor G Calina, Tobias Janik, Elena Grafenhorst, Eliane T Taube, Christopher Cm Neumann, Baoqing Chen, Elena I Braicu, Jalid Sehouli, Thomas Malinka, Wenzel Schöning, Johann Pratschke, George A Calin, David S Klimstra, Jamal K Benhamida, Irene Esposito, Markus Möbs, David Horst, Simon Schallenberg, David Capper, Mihnea P Dragomir

Faculty, Staff and Student Publications

The origin of mucinous cystic neoplasms (MCNs) remains a major challenge in hepato-pancreato-biliary pathology. These cystic tumors are defined by their mucinous epithelium and ovarian-like stroma, with an estimated 10% risk of progression to invasive carcinoma. The origin of the ovarian-like stroma remains a subject of debate. In this study, we conducted immunohistochemical profiling, targeted DNA sequencing, and genome-wide DNA methylation analysis on a cohort of 15 pancreatic MCNs (MCN-P) and six hepatic MCNs (MCN-L). Using immunohistochemistry and targeted DNA sequencing, we unequivocally established the diagnosis of MCN. Unsupervised DNA methylation profile analysis of reference classes of pancreatic neoplasms (11 …

Designing An Electronic Patient-Reported Outcomes Information Infrastructure Supported By The Re-Aim Implementation Framework, Amy C Moreno, Angela Peek, Toshiko S Stein, Kevin R Shook, Sara M Ali, Laia Humbert-Vidan, Aileen Chen, Miriam Lango, Anna Lee, Michael Spiotto, William H Morrison, Adam S Garden, Jack Phan, Steven J Frank, Katherine Hutcheson, David I Rosenthal, Clifton D Fuller, G Brandon Gunn

Faculty, Staff and Student Publications

Objective: Patient-reported outcomes (PROs) contain valuable information that can be leveraged by providers to perform timely interventions and improve quality of life and survival. However, the implementation of electronic PROs (ePROs) remains a challenge from technical and evaluation perspectives. Our objective was to construct a robust electronic health record (EHR)-integrated ePRO information infrastructure founded on RE-AIM (reach-effectiveness-adoption-implementation-maintenance) principles.

Materials and methods: We used Epic Systems as our EHR platform to build the MD Anderson Symptom Index Head and Neck Module (MDASI-HN) for release to all patients undergoing evaluation and/or treatment in our HN Radiation Oncology clinics. RE-AIM metrics were established …

Using Extension-Based Mrna Display To Design Antibody-Like Proteinogenic Peptides For Human Pd-L1, Justin N Ong, Brian J Grindel, Scott A Rankin, Sarah H Naylon, Anupallavi Srinivasamani, Guillaume J Trusz, Xiaowen Liang, Md Nasir Uddin, Lauren Fuller, Michael Curran, Stephane P Roche, Terry T Takahashi, Richard W Roberts, Steven W Millward

Faculty, Staff and Student Publications

Many peptide drugs rely on nonproteinogenic amino acids and chemical modifications for improved activity and proteolytic stability. However, these features also make drug production expensive and challenging to scale. Here, we engineered small, linear, proteinogenic peptides that bind human programmed death-ligand 1 (hPD-L1) with high affinity and stability using mRNA display affinity maturation. The resulting peptides, SPAM2 and SPAM3, have antibody-like affinities for hPD-L1 (dissociation constants between ~250 and 300 pM) and are selective for hPD-L1. Both SPAM2 and SPAM3 compete with hPD-L1 ligands known to interact with the programmed cell death protein 1 site and are stable in human …

Mechanisms Underlying Treatment-Resistant Depression: Exploring Sex-Based Biological Differences, Francisco E R Da Silva, Atakan Yucel, Antonio P M Menezes, Ana C Ruiz, Marcela C Carbajal Tamez, Tatiana Barichello, Giselli Scaini, Joao Quevedo

Faculty, Staff and Student Publications

Treatment-resistant depression (TRD) represents a severe and complex subtype of major depressive disorder (MDD), affecting approximately 30% of patients who fail to respond adequately to multiple standard antidepressant therapies. While the pathophysiology of TRD remains incompletely understood, emerging evidence suggests that sex-based biological differences might influence its onset, progression, and treatment response. Women are disproportionately affected by depression and are more likely to experience residual symptoms and treatment resistance, potentially due to hormonal fluctuations, immune system differences, and variations in brain circuitry and neuroplasticity. This narrative explores the current literature on the mechanisms underlying TRD, with a particular emphasis on …

Peripartum Depression Pharmacotherapies Targeting Gaba-Glutamate Neurotransmission, Alan C Courtes, Louisa Smitherman, Lokesh Shahani, Jair C Soares, Laura Goetzl, Rodrigo Machado-Vieira

Faculty, Staff and Student Publications

Peripartum depression (PPD) represents a significant public health concern, affecting 10-17% of women globally. Traditional monoaminergic treatments demonstrate limited efficacy and delayed onset of action. The glutamate-GABA imbalance hypothesis provides a novel theoretical framework for understanding depression pathophysiology and developing targeted therapeutic interventions. This review examines emerging pharmacotherapeutic approaches targeting glutamatergic and GABAergic neurotransmitter systems for PPD treatment. Search criteria targeted randomized clinical trials investigating GABA-A-positive allosteric modulators (brexanolone, zuranolone, and ganaxolone) and NMDA receptor antagonists (ketamine and esketamine) in PPD patients. Brexanolone was the first neurosteroid to receive FDA approval for PPD, while zuranolone also shows promise. Ketamine and …

Spatial Colocalization And Molecular Crosstalk Of Myofibroblastic Cafs And Tumor Cells Shape Lymph Node Metastasis In Oral Squamous Cell Carcinoma, Ken Furudate, Shuya Kasai, Tadashi Yoshizawa, Yuya Sasaki, Kohei Fujikura, Shintaro Goto, Ryohei Ito, Koki Takagi, Tomoyuki Tanaka, Hiroshi Kijima, Kosei Kubota, Ken Itoh, Wataru Kobayashi, Koichi Takahashi

Faculty, Staff and Student Publications

Lymph node metastasis (LNM) is a critical prognostic factor for patients with oral squamous cell carcinoma (OSCC). Previous research has implicated the partial epithelial-to-mesenchymal transition of tumor cells and myofibroblastic cancer-associated fibroblasts (myCAFs) in the LNM process. However, the underlying molecular mechanisms remain poorly understood. Here, we conducted a comprehensive molecular analysis integrating original and publicly available OSCC data from bulk genome and transcriptome, single-cell transcriptome, and spatial transcriptome analyses. We found that myCAFs were quantitatively and functionally activated in LNM-positive samples and spatially colocalized with OSCC cells within the invasive tumor front (ITF), providing a niche that may facilitate …

The Brescia International Multidisciplinary Consensus Guidelines On The Optimal Pathology Assessment And Multidisciplinary Pathways Of Non-Pancreatic Neoplasms In And Around The Ampulla Of Vater (Peripan), Mohammad Abu Hilal, Bas A Uijterwijk, Daniël H L Lemmers, Boris V Janssen, Marc G Besselink, Denise Bianchi, Arantza Fariña, Noriyoshi Fukushima, Anthony J Gill, Seung-Mo Hong, Alyssa Krasinskas, Claudio Luchini, Laura Melocchi, Giulio Rossi, Aldo Scarpa, Olca Basturk, Deyali Chatterjee, Angela Chou, Irene Esposito, Roger Feakins, Bas Groot Koerkamp, Ralph H Hruban, Stefano La Rosa, Chanjuan Shi, Aatur Singhi, Joanne Verheij, Huamin Wang, Sergio Alfieri, Fabio Ausania, Adnan Alseidi, Marco J Bruno, Ugo Boggi, Claudio Bnà, Christos Dervenis, Massimo Falconi, Michele Ghidini, Jakob W Kist, Giovanni Marchegiani, Michele Milella, Roberto Salvia, Ajith Siriwardena, Hanneke Wilmink, Alberto Zaniboni, Shaimaa Al-Janabi, Maia Blomhoff Holm, Eva Roos, Naoki Sano, In Hye Song, Zeynep Tarcan, Gianpaolo Balzano, Isabella Frigerio, Alfredo Guglielmi, Giuseppe Malleo, Horacio Asbun, Volkan Adsay, Caroline Verbeke

Faculty, Staff and Student Publications

IMPORTANCE: The lack of multidisciplinary workflow guidelines and clear definitions and classifications for neoplasms in and around the ampulla of Vater results in inconsistencies affecting patient care and research.

OBJECTIVE: The PERIPAN international multidisciplinary consensus group aimed to standardize the multidisciplinary diagnostic workflow and achieve consensus on definitions and classifications in order to ensure proper classification and optimal diagnostic assessment and consequently to improve patient care and future research.

DESIGN: An international team of 43 experts (pathologists, surgeons, radiologists, gastroenterologists, oncologists) from 12 countries identified knowledge gaps, reviewed 37061 articles, and proposed recommendations using the Scottish Intercollegiate Guidelines Network methodology …

Lifecycles Of Cochrane Systematic Reviews (2003-2024): A Bibliographic Study, Shiyin Li, Chong Wu, Zichen Zhang, Mengli Xiao, Mohammad Hassan Murad, Lifeng Lin

Faculty, Staff and Student Publications

Background and objectives: The relevance of Cochrane systematic reviews depends on timely completion and updates. This study aimed to empirically assess the lifecycles of Cochrane reviews published from 2003 to 2024, including transitions from protocol to review, update patterns, and withdrawals.

Methods: We extracted data from Cochrane Library publications between 2003 and 2024. Each review topic was identified using a unique six-digit DOI-based ID. We recorded protocol publication, review publication, updates, and withdrawals (i.e., removed from the Cochrane Library for editorial or procedural reasons), calculating time intervals between stages and conducting subgroup analyses by review type.

Results: Of 8137 protocols, …

Comparative Pathology Boards Facilitate The Translation Of Knowledge Between Canine And Human Cancer Patients, Jessica A Beck, Christina Mazcko, Sara Belluco, Mireille Bitar, Daniel Brat, Jonathan W Bush, Rati Chkheidze, Kara N Corps, Chad Frank, Caterina Giannini, Craig Horbinski, Jason T Huse, Jennifer W Koehler, Andrew D Miller, C Ryan Miller, M Gerard O'Sullivan, Joanna J Phillips, Daniel R Rissi, Courtney R Schott, Anat Stemmer-Rachamimov, Stephen Yip, Amy K Leblanc

Faculty, Staff and Student Publications

Comparative pathology boards bring together anatomic pathologists with expertise in canine and human histology to identify shared features, including immune or TME components, tumor subtypes, or prognostic tissue biomarkers. This article summarizes feedback to improve future initiatives and enhance the translational relevance of comparative oncology for human patients.

Risk Of Second Primary Lung Cancer Among Cancer Survivors Stratified By The Site Of First Primary Cancer And The Lung Cancer Screening Eligibility Status, Sara Nofal, Edwin J Ostrin, Jianjun Zhang, Jia Wu, Paul Scheet, Mara B Antonoff, John V Heymach, Iakovos Toumazis

Faculty, Staff and Student Publications

Personal history of cancer is an independent risk factor for developing lung cancer. However, it is not considered in the current US lung cancer screening (LCS) guidelines. In this study, we assessed the risk of developing lung cancer among cancer survivors across 24 different sites of first primary cancer stratified by their LCS eligibility status. Using data from the Patient History Database at the University of Texas MD Anderson Cancer Center, we calculated and compared the cumulative incidence of second primary lung cancer, the overall and the LCS eligibility status-specific, stratified by the site of first primary cancer among cancer …

Decadal Change In Deep-Ocean Dissolved Oxygen In The North Atlantic Ocean And North Pacific Ocean, Henry A. Ruhl, Christine L. Huffard, Monique Messié, Thomas P. Connolly, Thomas Soltwedel, Frank Wenzhöfer, Rodney J. Johnson, Nicholas R. Bates, Susan Hartman, Anita Flohr, Edward W. Mawji, David M. Karl, James Potemra, Fernando Santiago-Mandujano, Tetjana Ross, Kenneth L. Smith

Faculty Research, Scholarly, and Creative Activity

Declining dissolved oxygen concentrations are documented at upper and mid ocean depths, but less is known about the deep ocean. Long time-series measurements of dissolved oxygen analyzed with Winkler titration over several decades reveal regional differences at six stations in the abyssal North Atlantic Ocean and North Pacific Ocean. A significant decline in dissolved oxygen was evident at two stations in the northeast Pacific Ocean at 4000–4200 m depth (Stations PAPA and M). A similar decreasing but insignificant trend was recorded in the Arctic region of the North Atlantic Ocean (HAUSGARTEN). However, there was no significant decrease in dissolved oxygen …

Dental Shame: A Call For Understanding And Addressing The Role Of Shame In Oral Health, Louise Folker, Luna Dolezal, Astrid Pernille Jespersen, Martha Paisi, Lyndsey Withers, Christina Worle, Esben Boeskov Øzhayat

Peninsula Medical School

This commentary highlights dental shame as a pervasive but underexplored phenomenon with significant implications for oral health and systemic inequities. It proposes dental shame as a critical lens for understanding and addressing the complex interplay between personal, social, economic, cultural and systemic factors contributing to oral health challenges. Drawing on interdisciplinary expertise, the authors collectively propose that dental shame is both a consequence and determinant of oral health issues, leading to a self-reinforcing dynamic of avoidance, withdrawal and exacerbated inequities. They identify five key aspects of oral health where dental shame warrants deeper investigation: clinical encounters, care and social services, …

Leveraging Stellar Chemistry For A Global View Into The Atmospheres Of Brown Dwarfs And Giant Exoplanets, Emily Calamari

Dissertations, Theses, and Capstone Projects

In the era of the James Webb Space Telescope (JWST), it is now possible to examine substellar mass atmospheres in unparalleled detail and precision. However, unraveling the complicated thermodynamics and chemistry in these atmospheres remains a challenge. Atmospheric retrievals are a leading data-driven technique capable of recovering an object’s fundamental parameters such as mass, radius, effective temperature, gravity, cloud structure and composition and chemical abundances. However, in directly imaged or isolated worlds, constraining and/or interpreting these fundamental parameters can be difficult, particularly as retrieval models try to parameterize the overall impact of clouds.

For my dissertation, I turned to main …

Asian American Artists, Improvisation, And Collaboration, Johnna Wu

Dissertations, Theses, and Capstone Projects

The purpose of my dissertation is to explore how contemporary Asian Americans artist-performers have formulated their identities through collaborations with the Association for the Advancement of Creative Musicians (AACM). The project addresses issues in the existing literature on this topic and provides an alternative framework of cosmopolitanism to understanding the multidimensional aspects of artistic collaborations. The dissertation examines the history of the AACM and the Asian American improvisers and reveals ideological differences among its members on how music should reflect their identities. These histories paved the way for the artist subjects of my three case studies: Miya Masaoka, Vijay Iyer, …

The Architecture Of Exclusion: Disability, Race, And The History Of New York City’S 600 Schools, Francine Almash

Dissertations, Theses, and Capstone Projects

This dissertation investigates the largely erased history of New York City’s 600 schools—segregated public schools created to house students labeled as emotionally disturbed or socially maladjusted. These institutions, operating throughout the mid-20th century, disproportionately served Black and Puerto Rican youth, many of whom were placed in these schools under vague behavioral criteria and with little to no pathway for return to general education settings.

Combining archival research, longitudinal policy analysis, historical media review, and critical race and disability studies frameworks—including DisCrit (Disability Critical Race Theory)—this project situates the 600 schools at the intersection of institutional racism and ableism. It argues …

The Effect Of Tbi On Working Memory And Anxiety In Rats, Mariola Sobolewska

Dissertations, Theses, and Capstone Projects

Traumatic Brain Injury (TBI) is a significant public health concern, often leading to cognitive and emotional impairments. This study examined the effects of TBI on working memory and anxiety-like behavior in young male Sprague-Dawley rats using the Radial Arm Maze (RAM) and Elevated Plus Maze (EPM), which are behavioral assessments. The RAM tests spatial working memory by evaluating the animal’s ability to remember and efficiently navigate multiple arms to retrieve rewards. The EPM assesses anxiety-like behavior based on the animal’s preference for open versus closed arms. The study utilized young male Sprague-Dawley rats, a well-established rodent model known for its …

Between The Buffer And The Black Box: Ed(1), Invisible Text, And Delegation In Word Processing, Kai Prenger

Dissertations, Theses, and Capstone Projects

This thesis provides a media archaeological and theoretical examination of ed(1), the Unix line editor developed by Ken Thompson at Bell Labs in 1969, arguing that its approach to "invisible text" processing established lasting patterns of human-computer collaboration that persist in contemporary digital systems. Through historical research, technical analysis, and critical interpretation, this study demonstrates how ed(1) embodied a particular epistemology of text processing that appears alien in a contemporary context, but proves insightful in the age of generative text creation.

ed(1) emerged from the unique convergence of Bell Labs' collaborative research culture, severe hardware constraints of early Unix systems, …

Online Resources For Oral Communication Courses, Sean P. Palmer

Dissertations, Theses, and Capstone Projects

Online resources focusing on oral communication skills are lacking, even as online education itself expands. While I was aware of this lack, I didn’t realize its severity until LaGuardia Community College went fully remote during the 2020 global pandemic, and I was looking for online tutoring aids for oral communication. Furthermore, the information presented online is frequently unsuitable for the purposes of online pedagogy due to its specialized and jargony mode of presentation. Also, many existing assignments involving oral communication assume public speaking as the default model, despite the growing importance of emergent digital modes of oral performance, like podcasting …

Prerogative In Common: On The Emancipatory Potential Of Radical Mutuality Amid Sovereign Decisionism, Matthew Builes

Dissertations, Theses, and Capstone Projects

In times of crisis, liberal democracies resort to authoritarian measures that undermine core democratic values. Dominant thought in the study of emergency-era law and politics appeal to a dichotomy of normal and exceptional times, to critique or justify the turn to sovereign decisionism. While this strategy seems clear-cut, the persistence of exceptional spaces and the crises that supposedly generate them challenge existing frameworks by blurring the line between norm and exception. This project explores the prospect of radical mutual aid, as a transformative response to the enduring crisis of modernity.

Detecting Sonic Hedgehog Expression In The Adult Mouse Brain Using A Gene Expression Tracer, Kendra Stephens-Jones

Dissertations, Theses, and Capstone Projects

Sonic Hedgehog (Shh) is best known for its role in development, yet evidence supports Shh signaling plays a functional role in the adult brain. Previous work demonstrated that Shh is expressed by dopamine (DA) neurons in the ventral midbrain and that loss of Shh from these neurons leads to late-onset motor and structural abnormalities resembling Parkinson’s disease. However, the extent of Shh expression and its connectivity to the striatum in the adult mouse brain remain unclear due to the lack of reliable antibodies for Shh detection. To address this gap, the present study employed Shh ^L/L and DAT-Cre^+/- mice …

Behavioral Biomarkers Of Vulnerability In The Aba Model, Nora Ozer

Dissertations, Theses, and Capstone Projects

Anorexia nervosa (AN) is a severe psychiatric disorder with the highest mortality rate among mental health conditions, yet effective biological treatments remain limited. The activity-based anorexia (ABA) paradigm, which combines food restriction with wheel access to model the hyperactivity and self-starvation cycle characteristic of AN, shows considerable individual variability in vulnerability. Understanding what predisposes certain individuals to develop the full ABA phenotype while others remain resilient could inform early intervention strategies for human AN. This study employed continuous behavioral monitoring technology to identify early predictors of vulnerability to activity-based anorexia in mice, with the goal of discovering behavioral biomarkers that …

Processing Of Diphthongs By Turkish English Bilinguals: An Erp Study, Ecem Kopuz

Dissertations, Theses, and Capstone Projects

This study examines how native phonological experience influences the brain’s response to speech sounds in Turkish-English late bilinguals and English monolinguals. We asked whether neural responses reflecting encoding of auditory information would be sensitive to language specific experience. Using event-related potentials (ERPs), and specifically, the Acoustic Change Complex (ACC) we measured neural responses to four stimuli, /u/, /ua/, /iu/, and /ia/, where vowel quality changes for three of these. A change from /u/ to /a/ or /i/ to /a/ within a syllable (as in [ua] and [ia]) represents a clear vowel quality shift. All participants were expected to show sensitivity …

Crisis Narratives And The Vicissitudes Of Haitian Foodways: A Critical Comparison Of Three Food Items, Marc S. Gabriel

Dissertations, Theses, and Capstone Projects

Polities and media external to Haiti direct a lot of narrative focus on the country being the source of its own protracted crises. This represents a powerful narrative hegemony that casts the post-colonial nation as a zone of perpetual disasters or crisis. To maintain that narrative domination over Haiti, opportunistic observers of Haiti’s media spectacles of crisis only need to atomize the country’s newest crisis or natural disaster from the history that situates it. The elision of the Haitian memory – a memory of structural adjustment programs, systematic displacement, foreign-sponsored paramilitary violence, erosion of peasant foodways and agriculture – from …

Temporal Patterns Of New Product Introductions And Ipo Value: The Importance Of Recency, Dispersion, And Asymmetry, Suyun Mah, Rebecca J. Slotegraaf, Girish Mallapragada

Research Collection Lee Kong Chian School Of Business

A firm’s innovation activity is often judged by the number and type of new products it launches, but when these products are introduced may be equally important, especially before going public. This research investigates how the temporal pattern of new product introductions (NPIs) influences a firm’s initial public offering (IPO) value. The analysis uses data from 298 firms that went public between 2006 and 2023, and focuses on three patterns of timing: recency (how recently the latest product was launched before the IPO), dispersion (the degree to which NPIs before the IPO are spread out over time), and asymmetry (how …