Digital Commons Network^™

Employee Perception Of Manager Listening Behaviors And The Impacts On The Supervisor-Subordinate Relationship, Esther Song

Theses and Dissertations

Strong communications skills are one of the most coveted capabilities in the workplace today. Within two-way communication, listening is often overlooked as a critical skill. While there have been many theories and skill-based training around listening, it is difficult to find a consistent, global definition to listening. This lack of definition makes is challenging to assess what “good” listening skill entails. Moreover, this lack of definition creates a gap in understanding effective measures for listening in the workplace, particularly in assessing the supervisor/subordinate relationship. This study focused on understanding listening in the workplace. In particular, this study looked at employee …

Training And Resource Manual: Integrating And Exploring Language And Cultural Competencies For Trainees And Supervisors, Patricia Rayas-Tabares

Theses and Dissertations

This dissertation explored the scholarly literature and extracted important themes regarding the training and development of bilingual psychology trainees. The first theme was the language challenges bilingual trainees face due to their proficiency in Spanish when delivering services to Latinx limited English-speaking or monolingual Spanish-speaking clients when the trainee has received little or no training in Spanish. The second theme was bilingual supervision. When the trainee was matched with a supervisor who was not from the same culture or proficient in Spanish, many challenges occurred for the trainee and the supervisor. The final theme was about the trainee’s experience. Bilingual …

Upskilling California’S Public Health: An Assessment Of An Online Data Science Program, Michelle Ruiz

Theses and Dissertations

The COVID-19 pandemic exposed critical gaps in public health workforce data capabilities, prompting increased investment in data science training. This instrumental case study examined the effectiveness of University of California, Berkeley School of Public Health's online data science training program, developed in partnership with the California Department of Public Health to strengthen the state's public health workforce. The study analyzed program artifacts collected between October 2023 and September 2024, including Course Analytics Reports documenting enrollment patterns and Course Evaluation Reports structured according to considering the first two levels of Kirkpatrick's Four-Level Training Evaluation Model (1994). Analysis of nine courses revealed …

The Impact Of Covid-19 On Autistic Youth Mental Health, Chase Keyler

Theses and Dissertations

This systematic literature review explores the experiences of autistic youth during the COVID-19 pandemic and their ongoing adjustment in a post-pandemic world. It focuses on three primary concerns: the impact of the COVID-19 pandemic on ASD youth’s mental health, the factors influencing their adjustment during and after lockdown, and post-pandemic recommendations for clinicians and stakeholders. A comprehensive electronic literature search was conducted across six databases within the EBSCOhost platform. Study selection consisted of three phases: an initial screening (title and keywords), a partial review (title, keywords, and abstract), and a full- text analysis. The results of this systematic review indicate …

Mental Silence For Emotional Intelligence Development, Mina N. Nandwani

Theses and Dissertations

While emotional intelligence is considered key for effective leadership, and perhaps the most vital competency for current and emerging leaders to cultivate, there appears to be uncertainty on how to develop it. This study examined how the practice of Sahaja Yoga Meditation (SYM) influences the development of emotional intelligence and contributes to the advancement of global leadership capacities, addressing a gap in the current literature. The conceptual frameworks of SYM, Daniel Goleman’s Emotional Intelligence Model, and the literature on global leadership, particularly Jeffrey Sachs’ Ages of Globalization, guided the research question. By implementing a qualitative phenomenological research approach, ten long-time …

Student Success, Suicide Rates: A Correlational Study Of Pressures On, And Expectations For High School Students In The United States, Matthew Baham

Theses and Dissertations

Suicide among high school students has become a growing health crisis, with mental health issues such as anxiety, depression, and suicidal ideation increasing at an alarming rate. The purpose of this quantitative research is to explore the correlation between high school graduation requirements, pressures associated with college applications, and rising suicide rates among high school aged students in grades 9 through 12. With the increase in academic demands, standardized tests, extracurricular activities and a competitive college admissions process, has created an enormously high-pressure environment in high school education. These stressors are shown to have an intense impact on high school …

Resilience And Stress: Trauma, Grit, Resilience And Perceived Organizational Support In First Responders, Paige Gallas Parker

Theses and Dissertations

First responders comprise an underserved and under-researched population, despite consensus that their work involves exposure to potentially traumatic events. Inconsistent definitions of “first responder” and unclear prevalence rates of posttraumatic stress symptoms (PTSS) limit efforts to assess and promote resilience. This study examined the relationships between grit, resilience, perceived organizational support, and trauma symptoms in a sample of 234 first responders (69% firefighters, 29% lifeguards) employed by a large West Coast fire department. Measures included a demographics questionnaire, the Professional Exposure to Traumatic Events (PETE), the Posttraumatic Stress Disorder Checklist (PCL-5), the Connor-Davidson Resilience Scale (CD-RISC-10), the Short Grit Scale …

Educating Outdoors: A Qualitative Case Study On School Readiness Development In A Nature-Based Preschool, Lauren Lefevre

Theses and Dissertations

Play is widely considered one of the most crucial activities for healthy early childhood development, yet many current early childhood education (ECE) programs prioritize academics at the expense of this critical activity. Despite this focus on math and literacy skills, a significant number of children arrive at kindergarten unable to demonstrate proper school readiness. Nature-based early childhood education (NbECE) is a growing alternative education option that prioritizes risky play, loose parts play, and nature play, potentially providing children with countless opportunities for school-readiness development through play. Guided by the biophilia hypothesis (Wilson, 1984), which suggests that humans are innately drawn …

Evaluating The Clinical Effectiveness Of Psychodynamic Psychotherapy: A Systematic Review Of Outcome Studies, Gregory Bendau

Theses and Dissertations

The present review systematically examined current outcome studies on psychodynamic psychotherapy to build a comprehensive understanding of its overall effectiveness. The review synthesizes 43 outcome studies, including randomized controlled trials (n = 26) and quasi-experimental designs (n = 17), across diverse durations, settings, and clinical presentations. The review included quantitative, peer-reviewed studies written in English and published between 2015 and 2024 that measured the treatment outcomes of psychodynamic psychotherapy. Results showed that 41 studies (95%) reported significant symptom improvements for psychological conditions and disorders, including mood, personality, anxiety, somatic symptom, trauma, eating, mixed disorders, and general psychological distress. Effect sizes …

Generative Ai's Impact On Student's Motivation And Well-Being In Online Graduate Programs: A Phenomenological Study Through Self-Determination Theory, Sohee Linda Lee

Theses and Dissertations

While higher education has increasingly embraced emerging technologies, limited research explores how adult learners at the graduate level navigate AI-driven feedback, content generation, and learning supports, particularly within online programs that require self-regulation and advanced academic rigor. To address this gap, this qualitative, phenomenological study examined how graduate students enrolled in online degree programs experience and interpret the use of generative AI (GenAI) tools, such as ChatGPT, in their coursework. Drawing on Self-Determination Theory (SDT), this study focused on how the use of GenAI tools may influence students’ perceptions on autonomy (volition and choice in tasks), competence (confidence in academic …

Empowered Creation: Investigating Business Acumen And Technological Engagement Among Female Artists As Creative Entrepreneurs, Heggins-Jackson Tracey

Theses and Dissertations

The most powerful vehicle for communication and change is art. Creative endeavors have served humanity as a source of motivation and inspiration, as agents for shaping meaning and, most importantly, evoking empathy. Unfortunately, women in the arts face significant challenges due to deeply entrenched stereotypes, social expectations, societal norms, and gender-related misinformation, which result in destructive narratives. Paradoxically, this marginalized population possesses the skills and insights needed to address disparities through authentic narrative dissemination. Research indicates a limited focus on the contributions and pathways of women in the creative arts industry as entrepreneurs, explicitly highlighting their genuine needs conveyed through …

Latina Physician Assistants In Clinical Leadership Roles: Motivations, Challenges, And Insights, Ana Ruiz-Peña

Theses and Dissertations

Despite the rapidly growing Latino population in the United States, only a few of them are physicians, physician assistants (PAs), or nurses. This limited representation becomes smaller with Latina PAs in clinical leadership roles, leading to a health disparity that could negatively impact the health care of the Latino community. To gain a deeper understanding of this issue, the researcher conducted a phenomenological qualitative study examining the lived experiences of Latina PAs in clinical leadership roles, focusing on their motivations, challenges, and strategies for overcoming these barriers. The study was theoretically grounded in theories related to culture, gender, and socioeconomic …

Leveling The Playing Field: A Phenomenological Study Advocating For Diversity In Nba And Wnba Sports Organization Leadership, Alejandra Jimenez

Theses and Dissertations

Through phenomenological research, a global leadership and change initiative is outlined for US-based sports organizations. The sports organizations are the National Basketball Association (NBA) and their extended female league, the Women’s National Basketball Association (WNBA). Both organizations recruit international players, attract global fans, and enhance current diversity policies to promote underrepresented women and people of color in leadership. The NBA and WNBA public human resources and diversity policies provide underrepresented leadership rates and efforts for questionnaire data sets and qualitative interviews. Nationally, these major sports organizations should further develop policies and practices to increase Diversity, Equity, Inclusion, and Belonging (DEI&B) …

Developing A Gpt-Based Virtual Training System For Medical Undergraduates' History Taking In Stroke Rehabilitation, Chao-Yu Hsu, Ching-Lin Hsieh, Jeng-Cheng Wu, Wen-Hsuan Hou

Rehabilitation Practice and Science

Background: Effective history taking in stroke rehabilitation requires comprehensive assessment skills, yet opportunities for medical undergraduates to practice such skills remain limited. Virtual patients (VPs), especially those powered by large language models (LLMs), offer a promising solution. This study aimed to develop and evaluate a GPT-based virtual training system for functional assessments in stroke rehabilitation history taking.

Methods: A mixed-methods design was employed in which VPs were modeled on a clinical stroke case and 10 core domains of functional assessments in stroke rehabilitation were integrated. A virtual examiner (VE) module provided automated scoring and feedback. Phase 1 evaluated the reliability …

Building Diversity Into The Philosophy And Methodology Of Economics With Stratification Economics, Merve Burnazoglu, John B. Davis

Economics Faculty Research and Publications

Mainstream economics ignores who produces it and what it is about because its average man, Homo economicus ontological entry-point obscures social differences between people. Philosophy and Methodology of Economics that assumes this ontological entry point generally limits itself to epistemological analysis, and this means it fails to make diversity a fundamental concern. Taking diversity seriously entails being clear about one's ontological assumptions, and this requires being clear about the normative scope of one's analysis. This calls for giving up a value-neutral methodological reasoning and adopting a value-explicit methodological posture. To illustrate, we describe how Stratification economics with its social groups …

2024-2025 Annual Report, Heyman Center On Corporate Governance

Heyman Center Annual Reports

The Heyman Center FY25 Report highlights the Samuel & Ronnie Heyman Center on Corporate Governance at Cardozo School of Law, detailing its 2024–2025 programs in business and corporate law. It showcases events with leading scholars and practitioners, a wide curriculum with clinics and specialized programs, the selective Heyman Scholars Program, and the leadership of Executive Director Fabian Eichentopf alongside faculty directors and affiliated professors, emphasizing the Center’s role in shaping ethical business attorneys and future leaders.

Leaving It All Behind: A Storied Experience, Brandi Sheree Wynne Winfrey

UNF Graduate Theses and Dissertations

Diversity, equity, and inclusion (DEI) professionals are experiencing an unprecedented time as conservative politicians and legislators work to dismantle DEI in higher education. In 2022, Florida became one of the first states to introduce and enact anti-DEI legislation. Few studies have examined or investigated the lived experiences of DEI professionals currently living in the midst of this experience. The purpose of this narrative inquiry was to capture and restory the lived experiences of DEI professionals employed at public Florida universities during the introduction and enactment of anti-DEI legislation. Five co-composers contributed their stories of experience as data to this narrative …

High-Grade B-Cell Lymphoma Not Otherwise Specified, With Diffuse Large B-Cell Lymphoma Gene Expression Signatures: Genomic Analysis And Potential Therapeutics, Waseem Lone, Alyssa Bouska, Tyler A Herek, Catalina Amador, Joo Song, Dylan Jochum, Dennis D Weisenburger, Xuan Zhang, Sharath Kumar Bhagavathi, Tayla B Heavican-Foral, Sunandini Sharma, Ab Rauf Shah, Abdul Rouf Mir, Aisha Ahmad Alkhinji, Dalia El-Gamal, Bhavana J Dave, Keenan Hartert, Jiayu Yu, Mallick Saumyaranjan, Timothy C Greiner, Julie Vose, Timothy W Mckeithan, Kai Fu, Michael Green, Chengfeng Bi, Akil Merchant, Wing C Chan, Javeed Iqbal

Faculty, Staff and Student Publications

High-grade B-cell lymphoma not otherwise specified (HGBCL, NOS) has overlapping morphological and genetic features with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL), leading to uncertainty in its diagnosis and clinical management. Using functional genomic approaches, we previously characterized HGBCL and NOS, that demonstrate gene expression profiling (GEP), and genetic signatures similar to BL. Herein, we characterize distinct HGBCL, NOS, cohort (n = 55) in adults (n = 45) and in children (n = 10), and compared the GEP, genomic DNA copy number (CN), and mutational spectrum with de novo DLBCL (n = 85) and BL (n = 52). …

The Role Of Speech And Language Therapists (Slts) In International Stroke Teams: A Systematic Review, Marina Charalambous, John E Pierce, Georgia Pastou, Erasmia Kola, Sean I Savitz

Faculty, Staff and Student Publications

Background: Current published guidelines suggest that speech and language therapists (SLTs) should be part of stroke teams, but their involvement and roles according to country income are unknown.

Aims: This review aims to (1) investigate the level of involvement of SLTs in acute stroke management, rehabilitation, and long-term care, and (2) examine whether the roles and contributions of SLTs in stroke care vary according to a country's income level.

Methods: A systematic review methodology was conducted by an expert librarian and three independent researchers based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. This systematic review …

International Multicenter Retrospective Study From The Ultra-Rare Sarcoma Working Group On Low-Grade Fibromyxoid Sarcoma, Sclerosing Epithelioid Fibrosarcoma, And Hybrid Forms: Outcome Of Primary Localized Disease, Claudia Giani, Abdulazeez Salawu, Silva Ljevar, Ryan A Denu, Andrea Napolitano, Elizabeth A Connolly, Daniel D Wong, Roberto Scanferla, Evan Rosenbaum, Jyoti Bajpai, Zola Chia-Chen Li, Susie Bae, Lorenzo D'Ambrosio, Steve Bialick, Andrew J Wagner, Alexander T J Lee, Hanna Koseła-Paterczyk, Giacomo G Baldi, Antonella Brunello, Yeh Chen Lee, Herbert H Loong, Sosipatros Boikos, Fernando Campos, Carlo M Cicala, Robert G Maki, Nadia Hindi, Costanza Figura, Shahd S Almohsen, Sheyaskumar Patel, Robin L Jones, Toni Ibrahim, Rooshdiya Karim, Akira Kawai, Richard Carey-Smith, Richard Boyle, Silvia M Taverna, Alexander J Lazar, Elizabeth G Demicco, Judith V M G Bovee, Angelo P Dei Tos, Christopher Fletcher, Daniel Baumhoer, Marta Sbaraglia, Inga-Marie Schaefer, Rosalba Miceli, Alessandro Gronchi, Silvia Stacchiotti

Faculty, Staff and Student Publications

The aim of the study was to report the outcome of primary localized low-grade fibromyxoid sarcoma (LGFMS), sclerosing epithelioid fibrosarcoma (SEF), and hybrid LGFMS/SEF (H-LGFMS/SEF). Patients with primary localized LGFMS, SEF, or H-LGFMS/SEF, surgically treated with curative intent from January 2000 to September 2022, were enrolled from 14 countries and 27 institutions. Pathologic inclusion criteria were predefined by expert pathologists. The primary endpoint was overall survival (OS). Secondary endpoints were crude cumulative incidence (CCI) of local recurrence (LR), CCI of distant metastases (DM), and post-metastases OS (p-OS). Two hundred ninety-four patients (239 LGFMS, 32 SEF, and 23 H-LGFMS/SEF) were identified. …

Quantile Regression Based Method For Characterizing Risk-Specific Behavioral Patterns In Relation To Longitudinal Left-Censored Biomarker Data Collected From Heterogeneous Populations, Minjae Lee, Belinda M Reininger, Kelley Pettee Gabriel, Nalini Ranjit, Larkin L Strong

Faculty, Staff and Student Publications

There are many studies aimed at promoting positive lifestyle behaviors to reduce lifetime risk of cancer and related diseases. However, assessing these modifiable behaviors through statistical modeling is challenging because of the multidimensionality of interrelated measurements that may dramatically differ between at-risk individuals. Taking into account this heterogeneity while considering the multidimensionality of behavior changes is fundamental to tailoring interventions to their needs. Biomarkers that identify high-risk individuals may help validate proximal measures, but the number of validated methods that link biomarkers to multiple behavioral measurements by determining their dynamic relations with disease risks is limited to just a few, …

Plain Language Summary: An Analysis Of The Safety Of Futibatinib Treatment In People With Different Types Of Cancer, Funda Meric-Bernstam, Antoine Hollebecque, Junji Furuse, Do-Youn Oh, John A Bridgewater, Nanae Hangai, Lipika Goyal

Faculty, Staff and Student Publications

What is this summary about?: Researchers combined information from three separate phase 1 and 2 clinical trials, including over 400 people who had one of 33 different cancer types and who all received futibatinib in their clinical trial. This type of study is called a pooled analysis. Futibatinib is taken orally (by mouth) as a tablet and works by reducing the activity of a group of proteins called fibroblast growth factor receptors (FGFRs). FGFRs drive the growth of some cancers, especially cancer cells with changes in FGFR genes that make the proteins more active. Researchers wanted to look at how …

Psychometric Properties And Meaningful Change Thresholds For The Qol-E Instrument In Patients With Myelodysplastic Neoplasms, Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Giuseppe A Palumbo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G Pelligra

Faculty, Staff and Student Publications

peripheral blood cytopenias, and an increased risk of progression to acute myeloid leukemia. One of the main treatment goals is improving quality of life (QoL), particularly for patients with lower-risk MDS (LR-MDS) who may live longer with compromised QoL. The QOL-E© is a patient-reported outcome (PRO) measure specifically developed to address the lack of a health-related QoL questionnaire for patients with MDS. The objective of this study was to evaluate the psychometric performance of the QOL-E in patients with LR-MDS.

Methods: Data from four clinical trials in MDS (MEDALIST, DARB-MDS, EQoL-MDS, and RevMDS trials) were used to assess construct validity, …

Ntrk Fusion-Positive Thyroid Carcinoma: From Diagnosis To Targeted Therapy, Vicente R Marczyk, Sasan Fazeli, Ramona Dadu, Naifa L Busaidy, Priyanka Iyer, Steven I Sherman, Sayed Mohsen Hosseini, Michelle D Williams, Salmaan Ahmed, Mark J Routbort, Raja Luthra, Sinchita Roy-Chowdhuri, Francis Anthony San Lucas, Keyur P Patel, David S Hong, Mark Zafereo, Jennifer R Wang, Anastasios Maniakas, Steven G Waguespack, Maria E Cabanillas

Faculty, Staff and Student Publications

Purpose: Neurotrophic tropomyosin receptor kinase (NTRK) fusions may act as an oncogenic driver in thyroid carcinomas. Given their low frequency, clinical, pathological, and molecular data on these patients and their responses to targeted therapies are limited.

Methods: This is an observational retrospective study conducted at a single high-volume cancer center in the United States. Data were retrospectively collected from medical records.

Results: We included 65 patients (37 adult, 28 pediatric) with an NTRK fusion-positive thyroid carcinoma (24 NTRK1, 41 NTRK3), of which 54 were papillary thyroid carcinomas (PTC), four poorly differentiated thyroid carcinomas (PDTC), and seven …

Innovative Approaches In Precision Radiation Oncology: Advanced Imaging Technologies And Challenges Which Shape The Future Of Radiation Therapy, Yue Yan, Daniel A Alexander, Bryan P Bednarz, Lawrence F Bronk, Huixiao Chen, Bin Han, Yuting Li, Ngoc Nguyen, Natasha Mulenga, Natalie N Viscariello, Yuenan Wang, Joseph Weygand, Yana Zlateva, Fada Guan

Faculty, Staff and Student Publications

Radiation oncology is undergoing a transformative shift toward precision medicine through unprecedented advances in imaging technologies that enable increasingly personalized and adaptive cancer treatment. This comprehensive review synthesizes the underlying physical principles, current clinical applications, technical challenges, and quality assurance requirements across the complete spectrum of emerging imaging-guided radiation therapy approaches. We examine magnetic resonance-guided radiotherapy systems that enable daily soft-tissue visualization and online plan adaptation, positron emission tomography-guided platforms that allow real-time tracking of metabolically active tumor regions, advanced cone beam computed tomography systems supporting rapid adaptive workflows through artificial intelligence-enhanced image generation, and novel applications including Cherenkov radiation …

Consensus Guidelines For Delineation Of Clinical Target Volumes For Intensity Modulated Radiation Therapy For Intact Cervical Cancer: An Update, Emma C Fields, Walter R Bosch, Kevin V Albuquerque, Rohini Bhatia, Junzo Chino, Beth Erickson, David Gaffney, Scott Glaser, Kathy Han, Lara Hathout, I-Chow Hsu, Naresh Jegadeesh, Jenna Kahn, Elizabeth Kidd, Ann Klopp, Eric Leung, Lilie Lin, Michelle Ludwig, Tianjun Ma, Loren Mell, Jyoti Mayadev, Ivy Petersen, Lorraine Portelance, Dominique Rash, Neil Taunk, Akila Viswanathan, Aaron Wolfson, Catheryn Yashar, Anamaria Yeung, Emi Yoshida, Christine M Fisher

Faculty, Staff and Student Publications

Purpose: Accurate target delineation is essential when using intensity modulated radiation therapy for intact cervical cancer. In 2011, the Radiation Therapy Oncology Group published a consensus guideline using magnetic resonance imaging (MRI). The current project expands on the previous atlas by including computed tomography (CT)-based contours, contours with MRI and positron emission tomography (PET) registrations, the addition of common and complex scenarios, and incorporating information on simulation and treatment planning techniques.

Methods and materials: Twenty-eight experts in gynecologic radiation oncology contoured 3 cases, first on a noncontrast CT simulation scan and then with registered diagnostic scans. The cases included (1) …

Cord Blood-Derived Ink T Cells As A Platform For Allogeneic Car T Cell Therapy, Maison Grefe, Abel Trujillo-Ocampo, Jelita Clinton, Hong He, Ling Yu, Qing Ma, Jeffrey J Molldrem, Jin S Im

Faculty, Staff and Student Publications

CD1d-restricted invariant Natural Killer (iNK) T cells are a suitable candidate for allogeneic Chimeric Antigen Receptor (CAR) T cell therapy as they do not cause graft-versus-host disease (GvHD) due to the monomorphic nature of CD1d proteins. However, the phenotypic and functional heterogeneity of iNK T cells from adult donors (AD) may lead to the inconstant CAR-iNK T cell products. Cord blood-derived (CB) iNK T cells, in contrast, exhibit inter-donor homogeneity in phenotype including uniform CD4 expression and are enriched in memory iNK T cell populations. Thus, we evaluated the preclinical therapeutic potential of iNK T cells derived from cord blood …

Bismuth-Infused Perivascular Wrap Facilitates Delivery Of Mesenchymal Stem Cells And Attenuation Of Neointimal Hyperplasia In Rat Arteriovenous Fistulas, Allan John R Barcena, Joy Vanessa D Perez, Marvin R Bernardino, Jossana A Damasco, Erin Marie D San Valentin, Benjamin Martin, Francisco M Heralde, Natalie Fowlkes, Richard R Bouchard, Jizhong Cheng, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

BACKGROUND: Mesenchymal stem cells (MSCs) have emerged as novel therapies for supporting arteriovenous fistula (AVF) maturation, and bioresorbable polymeric scaffolds have enabled sustained MSC delivery into maturing AVFs. However, the radiolucency of biopolymeric wraps prevents in vivo monitoring of their integrity and location, hindering long-term preclinical investigations.

METHODS: We infused bismuth nanoparticles (BiNPs) into polycaprolactone (PCL) to fabricate an electrospun perivascular wrap capable of MSC delivery and conducive to longitudinal monitoring using conventional imaging. We tested the wraps' effects on the attenuation of markers of neointimal hyperplasia (i.e., endothelial dysfunction, hypoxia, and inflammation), the leading cause of AVF failure, in …

Burden Of Seasonal Human Coronavirus Infections In Hematopoietic Cell Transplant Recipients, Fareed Khawaja, Terri Lynn Shigle, Layale Yaghi, May Daher, Jeremy L Ramdial, Ying Jiang

Faculty, Staff and Student Publications

Background: Community respiratory viruses, such as seasonal human coronavirus (HCoV), commonly infect hematopoietic cell transplant (HCT) recipients. Recognizing the risk factors and outcomes of HCoV infections in HCT recipients is essential for the future development of potentially lifesaving therapeutics.

Methods: We performed a retrospective review of all HCoV-infected HCT recipients from September 1, 2015 to August 31, 2017, at our institution. Patients were classified with upper respiratory tract infection (URI) or lower respiratory infection (LRI) based on predefined definitions for respiratory viral infections in HCT recipients. Patient data were collected to identify risk factors for HCoV LRI, and to calculate …

Partial Agonism In Heteromeric Gluk2/Gluk5 Kainate Receptor, Nabina Paudyal, Anindita Das, Elisa Carrillo, Vladimir Berka, Vasanthi Jayaraman

Faculty, Staff and Student Publications

Kainate receptors are a subtype of ionotropic glutamate receptors that form transmembrane channels upon binding glutamate. Here, we have investigated the mechanism of partial agonism in heteromeric GluK2/K5 receptors, where the GluK2 and GluK5 subunits have distinct agonist binding profiles. Using single-molecule Förster resonance energy transfer, we found that at the bi-lobed agonist-binding domain, the partial agonist AMPA-bound receptor occupied intermediate cleft closure conformational states at the GluK2 cleft, compared to the more open cleft conformations in apo form and more closed cleft conformations in the full agonist glutamate-bound form. In contrast, there is no significant difference in cleft closure …