Digital Commons Network^™

Occupational Therapy’S Role In Working With Children With Complex Medical Needs, Maci Layne Bakken

Occupational Therapy Capstones

Background: Children with medical complexity (CMC) spend a lot of time in various medical facilities due to their conditions. One of the medical facilities available to families in the Midwest is a respite and hospice home for medically complex children. There are only three other homes like this in the United States. Due to symptoms of their conditions, functional limitations in skill development, and decreased opportunities to engage in the occupation of play, these children can experience occupational deprivation and decreased quality of life. At this specific respite and hospice home, there are many volunteers who sacrifice their time to …

Lung Uptake Of Two Spect Markers Identifies Sensitivity To Hyperoxia-Induced Acute Respiratory Distress Syndrome In Rats, Anne V. Clough, Taheri Pardis, Guru P. Sharma, Ming Zhao, Elizabeth R. Jacobs, Said H. Audi

Biomedical Engineering Faculty Research and Publications

Introduction: Exposure of adult rats to hyperoxia is a well-established model of human Acute Respiratory Distress Syndrome (ARDS). Although rats exposed to 100% O₂ display clinical evidence of lung injury after ∼40 h and death by 72 h, rats exposed to 60% O₂ for up to 7 days show little sign of injury. However, when subsequently exposed to hyperoxia, these pre-exposed rats become more susceptible to ARDS. The objective of this study is to evaluate the ability of imaging biomarkers to track this hyperoxia susceptibility and to elucidate underlying mechanisms.

Methods: Sprague-Dawley rats were exposed to either room …

Scoping Review Of Machine Learning Techniques In Marker-Based Clinical Gait Analysis, Kevin N. Dibbern, Maddalena G. Krzak, Alejandro Olivas, Mark V. Albert, Joseph J. Krzak, Karen M. Kruger

Biomedical Engineering Faculty Research and Publications

The recent proliferation of novel machine learning techniques in quantitative marker-based 3D gait analysis (3DGA) has shown promise for improving interpretations of clinical gait analysis. The objective of this study was to characterize the state of the literature on using machine learning in the analysis of marker-based 3D gait analysis to provide clinical insights that may be used to improve clinical analysis and care. Methods: A scoping review of the literature was conducted using the PubMed and Web of Science databases. Search terms from eight relevant articles were identified by the authors and added to by experts in clinical gait …

Whole Body Angular Momentum Characterizes Reactive Balance Adaptations And Perturbation Intensity, Mitchell D. Adam, Delaney Mcelvain, T. George Hornby, Allison S. Hyngstrom, Brian D. Schmit

Physical Therapy Faculty Research and Publications

Identifying measures which accurately quantify reactive balance adaptation during walking is essential to understand how emerging perturbation-based gait paradigms impact stability over the course of an intervention. These perturbation paradigms have shown promise in reducing falls for numerous clinical populations, however tracking progress in objective terms throughout an intervention remains challenging. Whole body angular momentum (H) may be particularly suited to detect subtle adaptations in the reactive balance response and is applicable within numerous perturbation environments. We assessed the ability of young healthy adults to adapt to varying intensities of discrete, unexpected, treadmill-based perturbations directed mediolaterally, anteriorly, and posteriorly during …

Age-Related Differences In Eye Movements And The Association With Archimedes Spiral Tracing Performance In Young And Older Adults, Brittany Heintz Walters, Wendy E. Huddleston, Kristian M. O'Connor, Jinsung Wang, Marie K. Hoeger Bement, Kevin G. Keenan

Physical Therapy Faculty Research and Publications

Age-related hand motor impairments may critically depend on visual information though few studies have examined eye movements during tasks of hand function in older adults. The purpose of this study was to assess eye movements and their association with performance while tracing on a touchscreen in young and older adults. Eye movements of 21 young (age 20–38 years; 12 females, 9 males) and 20 older (65–85 years; 10 females, 10 males) adults were recorded while performing an Archimedes spiral tracing task, a common clinical assessment sensitive to age-associated impairments in hand function. Participants traced an Archimedes spiral template on a …

Ai-Generated Messaging For Life Events Using Structured Prompts: A Comparative Study Of Gpt With Human Experts And Machine Learning, Christopher Lynch, Erik Jensen, Ross Gore, Virginia Zamponi, Kevin O'Brien, Brandon Feldhaus, Katherine Smith, Joseph Martínez, Madison H. Munro, Timur E. Ozkose, Tugce B. Gundogdu, Ann Marie Reinhold, Hamdi Kavak, Barry Ezell

VMASC Publications

Large Language Models (LLMs) play an increasingly integrated and pivotal role in generating diverse types of texts, such as social media messages, emails, narratives, and technical reports, among other textual communication forms. As AI-generated messaging filters into human communication, a systematic exploration of their effectiveness for mimicking human-like communication of life events is needed. In this study, we employ a zero-shot structured narrative prompt to generate 24,000 life event messages for birth, death, hiring, and firing events using OpenAI's GPT-4. From this dataset, we manually classify 2880 messages and evaluate their validity in conveying these life events through the form …

Physical Ablative Methods And Cancer Cell Death: Implications For Immunity And Therapies, Alessandra Rossi, Claudia Muratori

Bioelectrics Publications

Surgery has traditionally been a cornerstone in cancer treatment, yet its feasibility can be limited by factors such as tumor location and patient health conditions. When surgery is not viable, thermal and pulsed electric field (PEF)-based ablation technologies offer valuable alternatives. Emerging evidence suggests that these approaches not only target tumors effectively but also stimulate antitumor immune responses. In this review, we begin by examining the distinctive features of hyperthermic treatments (radiofrequency and microwave ablation), cryoablation, and PEF-technologies. Subsequently, we discuss the mechanisms of cell death, stress responses, and release of danger signals triggered by these diverse ablation technologies. Finally, …

Curing The Cancer Pledge: Three Legal Reforms To Support Employees With Cancer, Hannah R. Weiser, Elizabeth Brown

Lewis & Clark Law Review

The 2023 Super Bowl featured a short film about the #WorkingWithCancer Pledge, a business initiative supporting employees with cancer, to over 100 million viewers. This film highlighted the struggles of a disease that affects a shocking 50% of individuals. It also underscored the need for a broader and more impactful approach ensuring that people with cancer have as full and equitable opportunities to work as other employees. While cancer in the workplace is increasingly common, misconceptions and stigma surrounding cancer exacerbate the gaps in legal protections for both employees with cancer and their employers. Employees with cancer need better legal …

Abundance And Other Food Fixations, Margot J. Pollans

University of Colorado Law Review

No abstract provided.

Between A Rock And A Hard Place: Army Judge Advocates, Zach Cohen

University of Colorado Law Review

No abstract provided.

Medicalization Of Education: Applied Behavioral Analysis In Colorado's Schools, Zachary Quaratella

University of Colorado Law Review

No abstract provided.

Artificial Intelligence And Constitutional Interpretation, Andrew Coan, Harry Surden

University of Colorado Law Review

No abstract provided.

Algorithmic Bias And Accountability: The Double B(L)Ind For Marginalized Job Applicants, Chris Chambers Goodman

University of Colorado Law Review

No abstract provided.

Cultivating Hope: A Future With Ethics Towards People And Places, Vanessa Ann Racehorse

University of Colorado Law Review

No abstract provided.

Abandoned Mines, Abandoned Treaties: The Federal Government's Failure To Remediate Abandoned Uranium Mines On The Navajo Nation, Nadine Padilla

University of Colorado Law Review

No abstract provided.

Great Salt Lake And The Future Of Environmental Law, Brigham Daniels, Elisabeth Parker, Karigan Börk, Andrew P. Follett, Danny Dudley

University of Colorado Law Review

No abstract provided.

Forget It, Florida. It's Chinatown: The Return Of Immigrrant Land Laws In America, Hannah Corcoran

University of Colorado Law Review

No abstract provided.

The Cost Of Pfas Cleanup In Waterways: Who Pays And How, Sarah E. Mische

University of Colorado Law Review

No abstract provided.

Rights As Remedies: Using Latin American Legal Channels To Halt U.S. Border Externalization, Natalie Lerner

Lewis & Clark Law Review

The first Trump Administration saw intense border crackdowns and a ramping up of restrictions on asylum. While some of these policies shifted under President Biden, many were recreated under new names. The second Trump Administration has functionally closed the border and deported asylum seekers to third countries such as Costa Rica and Panama, leaning heavily on Latin American countries to accept expelled migrants. As U.S. courts fail to preserve asylum law domestically, international law, as integrated into the constitutions of Latin American countries, can provide a valuable litigation tool to block those countries from participating in the U.S. border externalization …

Retirement (In)Security: A Closer Look Into The United States' Retirement Crisis, Josepheen Strauss

Lewis & Clark Law Review

The retirement system in the United States is typically thought to consist of Social Security, pension plans, and personal savings. Despite the availability of various methods to save money, Americans are struggling more than ever to adequately prepare for retirement. This Note examines the current structure of the retirement system in the United States and the shortcomings of the system as it stands today. This Note proposes changes that re-envision the United States’ current retirement system to allow Americans to maximize their retirement savings during their time in the work force, with the hopes of allowing retirees to start their …

The Identity Factor, Jessica Feinberg

University of Colorado Law Review

No abstract provided.

Red Flag Officers, Rachel Moran

University of Colorado Law Review

No abstract provided.

The Hub-And-Spoke Model: How Everyone Can Get In On The Action In Colorado, Sebastian Blitt

University of Colorado Law Review

No abstract provided.

Cumulative Effects Of H+ And PI On Force And Power Of Skeletal Muscle Fibres From Young And Older Adults, Christopher W. Sundberg, Laura E. Teigen, Sandra K. Hunter, Robert H. Fitts

Biological Sciences Faculty Research and Publications

The cellular causes of the age-related loss in power output and increased fatigability are unresolved. We previously observed that the depressive effects of hydrogen (H+) (pH 6.2) and inorganic phosphate (Pi) (30 mm) did not differ in muscle fibres from young and older men. However, the effects may have been saturated in the severe fatigue-mimicking condition, potentially masking age differences in the sensitivity of the cross-bridge to these metabolites. Thus, we compared the contractile mechanics of muscle fibres from the vastus lateralis of 13 young (20–32 years, seven women) and 12 older adults (70–90 years, six women) in conditions mimicking …

Case Report: Disseminated Herpes Simplex Virus Complicated By Hemophagocytic Lymphohistiocytosis In A Neonate, Nicholas Tadros, Nihal Godiwala

School of Medicine Faculty Publications

Neonatal herpes simplex virus (HSV) infection carries a high mortality rate due to its potential to cause disseminated disease involving multiple organ systems, which can rapidly progress to shock and death if not promptly treated. In rare cases, neonates may mount an uncontrolled inflammatory response leading to hemophagocytic lymphohistiocytosis (HLH), a severe hyperinflammatory syndrome. We present a case of neonatal HSV infection complicated by HLH, highlighting the challenges of managing both conditions concurrently. Our therapeutic approach demonstrated a reduction in systemic inflammation and viral load; however, despite these efforts, the patient developed multiorgan failure and ultimately died from the initial …

A Non-Toxic Analgesic Elicits Cell-Specific Genomic And Epigenomic Modulation By Targeting The Pag Brain Region, Hernan A. Bazan, Brian L. Giles, Surjyadipta Bhattacharjee, Scott Edwards, Nicolas G. Bazan

School of Medicine Faculty Publications

Acetaminophen (ApAP) is widely used for pain management, but overuse or overdose leads to hepatotoxicity, making it the leading cause of acute liver failure globally. There is an urgent need for safer pain medications, as other non-opioid analgesics like non-steroidal anti-inflammatory drugs (NSAIDs) are nephrotoxic. We have identified SRP-001 as a safer, non-hepatotoxic, novel analgesic that overcomes ApAP's limitations by avoiding NAPQI formation and preserving hepatic tight junctions. Using coupled RNA and ATAC sequencing, from the periaqueductal gray (PAG) midbrain region, we compared the genetic and epigenetic signatures of SRP-001 and ApAP treatments following complete Freund's adjuvant (CFA)-induced inflammatory pain …

Penderitaan Tanpa Ukuran: Mengapa Kuhap Harus Segera Mengatur Kerugian Imateriil?, Setiani Budi Utami, Mardian Putra Frans

Jurnal Hukum & Pembangunan

Law enforcement must ensure that the justice process operates in accordance with the principles of true justice. The criminal justice system in Indonesia emerged as a response to public dissatisfaction with the performance of law enforcement agencies that overly emphasized formal law and order alone, without regard for human dignity. The preamble of the Criminal Procedure Code (KUHAP) affirms that this system aims to protect human dignity, thus substantive justice must be prioritized. In this context, human rights, particularly the protection of crime victims, become crucial. However, in practice, victims are often marginalized, especially regarding compensation for immaterial damages that …

An Assessment Of Vegetable Production Constraints, Trait Preferences And Willingness To Adopt Sustainable Intensification Options In Kenya And Uganda, Rose N. Okoma, Evanson R. Omuse, Daniel M. Mutyambai, Dennis Beesigamukama, Marius F. Murongo, Sevgan Subramanian, Frank Chidawanyika

All Peer-Reviewed Publications

Global food production systems are under pressure due to population increase, limited farmland, biotic and abiotic constrains, and ongoing climate change. Sustainable intensification is needed to increase agricultural productivity with minimal adverse environmental and social impacts. Vegetable-integrated push pull (VIPP) technology coupled with black soldier fly (BSF) frass offer such opportunities to smallholder farmers. However, farmers’ vegetable preferences and willingness to adopt these innovations remain unknown and are variable across various geographic scales. Focus group discussions (FGDs) and in-person interviews with smallholder farmers were conducted to assess vegetable production constraints and select vegetables to be integrated into VIPP coupled with …

Immunohistochemical Assessment Of Ki-67 In Oral Lichen Planus, Ibrahem Gamal, Mahmoud Fathy El-Sherbeny, Sherif Yousef El Nagdy, Nadia Abbas Ibrahim El-Sissy

Mansoura Journal of Dentistry

Objective: The purpose of the current study was to assess cell proliferation by analyzing the expression of Ki-67 in 30 cases of oral lichen planus (OLP). Material and methods: 30 archival paraffin blocks of OLP were examined for Ki-67 expression using immunohistochemical staining. Normal oral mucosa served as a control. After carefully examining the tissue samples, the number of positive cells was counted in order to semi-quantitatively characterize the expression pattern. Scores ranging from 1 to 3 were assigned to nuclear immunostaining for Ki-67 proliferation. SPSS-13 program was used for the statistical analysis, and p

Immunohistochemical Evaluation Of Cd10 In Ameloblastoma And Dentigerous Cyst, Mennatalla M. Abougamila, Mona M. A. Ibrahim, Lawahez El. M. Ismail

Mansoura Journal of Dentistry

Objectives: Expression of CD10 in Ameloblastoma and Dentigerous cyst via immunohistochemistry. Material and methods: The current work was carried out on thirty-one tissues embedded in paraffin and treated with formalin of Ameloblastoma and fourteen cases of Dentigerous cyst (DC) were taken from the Faculty of Dentistry's Oral Pathology Department's archives, Mansoura University. Immunohistochemical reagents: Cluster of differentiation (CD10) (Autostainer Link 48) Clone 56C6 Ready-to-use monoclonal mouse antibody. The area percentage of stained cells from five randomly selected fields was examined under ×400 magnification in order to determine the tissue immunoreactivity for CD10. Results: In the present study, we revealed a …