Digital Commons Network^™

Interaction Of Cardiac Leiomodin With The Native Cardiac Thin Filament, Madison Little, Cristina M. Risi, Tania M. Larrinaga, Mason D. Summers, Tyler Nguyen, Garry E. Smith Jr., Jennifer Atherton, Carol C. Gregorio, Alla S. Kostyukova, Vitold E. Galkin

Department of Biomedical and Translational Sciences Faculty Publications

Every heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere. Therefore, the maintenance of thin filament length is crucial for myocardium function. The thin filament is comprised of an actin backbone, the regulatory troponin complex and tropomyosin that controls interactions between thick and thin filaments. Thin filament length is controlled by the tropomodulin family of proteins; tropomodulin caps pointed ends of thin filaments, and leiomodin (Lmod) promotes elongation of thin filaments by a “leaky-cap” mechanism. The broader distribution of Lmod on the thin …

Clinical Pharmacology And Medication Safety: A Remote Learning Elective Designed For Senior Medical Students, Elizabeth B. Graham, William T. Wightkin, Curt R. Bay, Uzoma S. Ikonne

Department of Biomedical and Translational Sciences Faculty Publications

In the United States, medical educators have expressed concern that an integrated and condensed pre-clerkship curriculum risks leaving gaps in student pharmacology knowledge. This study evaluates a remote-learning clinical pharmacology elective that integrates fundamental pharmacology concepts and principles of medication safety and explores how the course impacts senior medical students' self-reported readiness for residency. Clinical Pharmacology and Medication Safety is a remote elective course for senior medical students. The course integrates a review of basic pharmacology with clinical pharmacology topics through case-based learning sessions led by clinical pharmacists and physicians. To evaluate the elective's effectiveness, students in the fall and …

The Central Role For Troponin C Amino-Terminal ⍺-Helix In Vertebrate Thin Filiment Ca²⁺-Activation, Yun Shi, Lauren A. Blackwell, Ryan K. Schroy, B. Max Cleland, Cristina M. Risi, Michelle S. Parvatiyar, Jose R. Pinto, Vitold E. Galkin, P. Bryant Chase

Department of Biomedical and Translational Sciences Faculty Publications

Troponin C (TnC) is the Ca²⁺-sensing subunit of troponin that is responsible for activating thin filaments in striated muscle, and, in turn, for regulating the systolic and diastolic contractile function of cardiac muscle. The secondary structure of vertebrate TnC is mainly composed of α-helices, with nine helices named sequentially, starting from the amino terminus, from N to A–H. The N-helix is a 12-residue-long α-helix located at the extreme amino terminus of the protein and is the only helical structure that does not participate in forming Ca²⁺-binding EF-hands. Evolutionarily, the N-helix is found only in TnC from mammalian species and most …

Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells, Ashley V. Huang, Yali Kong, Kan Wang, Milton L. Brown, David Mu

Department of Biomedical and Translational Sciences Faculty Publications

Breast cancer is one of the most common cancers globally. Unfortunately, many patients with breast cancer develop resistance to chemotherapy and tumor recurrence, which is primarily driven by breast cancer stem cells (BCSCs). BCSCs behave like stem cells and can self-renew and differentiate into mature tumor cells, enabling the cancer to regrow and metastasize. Key markers like CD44 and aldehyde dehydrogenase-1 (ALDH1), along with pathways like Wingless-related integration site (Wnt), Notch, and Hedgehog, are critical to regulating this stem-like behavior of BCSCs and, thus, are being investigated as targets for various new therapies. This review summarizes marker-dependent strategies for targeting …

Eeg Spectral Analysis Of Nighttime Sleep And Daytime Mslts And Neurocognitive Evaluations In Subjects With Co-Morbid Insomnia And Osa, Yuan Shi, Yuru Nie, Fengyi Hao, Xujun Feng, Ye Zhang, Larry D. Sanford, Rong Ren, Xiangdong Tang

Department of Biomedical and Translational Sciences Faculty Publications

Background

Chronic insomnia and obstructive sleep apnea commonly co-occur. Few studies have explored the neurophysiological and neurocognitive characteristics of COMISA, which could help guide improving treatment diagnostic tools and determining novel therapeutic targets. This study aims to explore the neurophysiological and neurocognitive characteristics of COMISA using electroencephalographic (EEG) spectral analysis and subjective and objective neurocognitive measurements.

Methods

Participants were from our community recruited OSA-insomnia-COMISA cohort with 206 included for our current analysis including 74 chronic insomniacs (CIs), 55 OSA patients and 77 COMISA patients. Standard polysomnography (PSG) and multiple sleep latency tests (MSLTs) were recorded and used to obtain relative …

Codon Composition In Human Oocyters Reveals Age-Associated Defects In Mrna Decay, Pavla Brachova, Lane K. Christenson, Nehemiah S. Alvarez

Department of Biomedical and Translational Sciences Faculty Publications

Oocytes from women of advanced reproductive age exhibit diminished developmental potential, but the underlying mechanisms remain incompletely defined. Oocyte maturation depends on translational control of maternal mRNA synthesized during growth. We performed a computational analysis on human oocytes from women < 30 versus ≥40 years and observed that mRNA GC content correlates negatively with half-life in oocytes from young (< 30 yr) but positively with oocytes from aged (>40 yr) women. In young oocytes, longer mRNA half-life is associated with lower protein abundance, whereas in aged oocytes GC content correlates positively with protein abundance. During the GV-to-MII transition, codon composition stratifies stability: codons that support rapid translation (optimal) stabilize mRNA, while slow-translating codons (non-optimal) promote decay. With reproductive aging, GC-containing codons become more optimal and align with increased …

Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas

Department of Biomedical and Translational Sciences Faculty Publications

Antibiotic resistance (AR) has become a critical global health crisis, threatening the efficacy of antibiotics and increasing healthcare costs, morbidity, and mortality. The One Health approach, which emphasizes the interconnectedness of human, animal, and environmental health, is increasingly recognized as an essential framework for addressing the complex drivers of AR. This review explores the mechanisms of resistance, such as genetic mutations, horizontal gene transfer, and biofilm formation, along with contributing factors such as the overuse of antibiotics in healthcare and agriculture. We assess both traditional and emerging strategies to combat AR, including antimicrobial stewardship, the development of new antibiotics, and …

Deletion Of Chop In Beta Cell Protects Mice From Cardiovascular Complications In Type 2 Diabetes: Evidence From A Pre-Clinical Mouse Model, Balaji Srinivas, Kiran Alluri, Nour-Eddine Rhaleb, Khalid Matrougui

Department of Biomedical and Translational Sciences Faculty Publications

Introduction

Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major independent risk factor for coronary artery disease, stroke, peripheral vascular disease, and heart failure. The interrelationship between metabolic dysfunction and cardiovascular disease is complex and multifactorial, involving hyperglycemia, insulin resistance, inflammation, and oxidative stress. Evidence indicates that endoplasmic reticulum (ER) stress and induction of the unfolded protein response (UPR) contribute to metabolic dysregulation and vascular dysfunction. However, the specific role of beta cell-derived UPR mediators, particularly C/EBP homologous protein (CHOP), in coordinating this interorgan axis between …

Swinging Lever Mechanism Of Myosin Directly Shown By Time-Resolved Cryo-Em, David P. Klebl, Sean N. Mcmillan, Cristina Risi, Eva Forgacs, Betty Virok, Jennifer L. Atherton, Sarah A. Harris, Michele Stofella, Donald A. Winkelmann, Frank Sobott, Vitold E. Galkin, Peter J. Knight, Stephen P. Muench, Charlotte A. Scarfi, Howard D. White

Department of Biomedical and Translational Sciences Faculty Publications

Myosins produce force and movement in cells through interactions with F-actin¹. Generation of movement is thought to arise through actin-catalysed conversion of myosin from an ATP-generated primed (pre-powerstroke) state to a post-powerstroke state, accompanied by myosin lever swing²,³. However, the initial, primed actomyosin state has never been observed, and the mechanism by which actin catalyses myosin ATPase activity is unclear. Here, to address these issues, we performed time-resolved cryogenic electron microscopy (cryo-EM)⁴ of a myosin-5 mutant having slow hydrolysis product release⁵,⁶. Primed actomyosin was predominantly captured 10 ms after …

Phenotype Specific Nuclear Lamina Remodeling In Hipsc Derived Cardiomyocytes Bearing Tnnt2 Sarcomeric Variants, Isabella Leite Coscarella, Olalekan H. Usman, Lili Wang, Maicon Landim-Vieira, Lillian Wirstiuk, Amber N. Brown, Diego A. R. Zorio, Brian K. Washburn, Cynthia Vied, Bjorn C. Knollmann, Christopher Solís, Vitold E. Galkin, P. Bryant Chase, J. Travis Hinson, Jerome Irianto, Jose Renato Pinto

Department of Biomedical and Translational Sciences Faculty Publications

[Summary] Cardiomyocytes endure physical stress from the myocardium environment while generating their own mechanical strains. The force generated by sarcomeres is transmitted both longitudinally to adjacent sarcomeres and laterally to the cytoskeleton via intermediate filaments. This mechanical stimulus impacts other organelles, including the nucleus, thus playing a vital role in sensing and signaling nuclear adaptations. However, there is limited understanding of how changes in cardiac contractility affect nuclear mechanics. Here, we sought to investigate the effects of hyper- and hypo-contractility in nuclei of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) bearing TNNT2 pathogenic variants associated with hypertrophic (HCM) or dilated …

Women Leaders' Lived Experiences Of Bravery In Leadership, Michelle E. Bartlett

Educational Leadership & Workforce Development Faculty Publications

Purpose

The research aims to understand the stories of women leaders who have demonstrated bravery in leadership. By analyzing their lived experiences through storytelling and narratives, it seeks to shed light on the challenges and motivations behind their brave actions, contributing to a deeper understanding of bravery in leadership within gender and organizational contexts.

Design/methodology/approach

This study adopts a qualitative multiple case study approach, focusing on the autobiographical accounts of three women leaders to explore their experiences of bravery in leadership. Utilizing narrative analysis (NA), it is grounded in ethical leadership theory and narrative identity theory. The research method involves …

Coastal Empire Economic Monitor, 1st Quarter, 2025, Georgia Southern University Center For Business Analytics And Economic Research

Coastal Empire Economic Monitor

• Forward Momentum Weakening

• Savannah Metro Economy Growth Slows

• U.S. Economy Shrinks, 2025 Outlook Remains Murky

• Forecasting Index Falls

If You Charge Them, Will They Come? The Effect Of Levying Tuition Fees In International Students, Charles Mathies, Hannu Karhunen, Stephen L. Desjardins

Educational Leadership & Workforce Development Faculty Publications

In 2017, Finland began levying tuition fees on non-European Union (EU)/European Economic Area (EEA) international students. Using data from multiple Finnish government sources, we study the impact of tuition fee reform at various stages of the higher education enrollment selection process. Outcomes examined include how the policy change affects student application behavior, admissions and acceptances by institutions, and student enrollments. To identify the effects of the policy change, we employ a difference-in-differences approach using national register data and program-level tuition variations. Our findings led to three key findings: (1) the implementation of fees did not decrease the number of applications …

Towards Dynamic Learner State: Orchestrating Ai Agents And Workplace Performance Via The Model Context Protocol, Mohan Yang, Nolan Lovett, Belle Li, Zhen Hou

Educational Leadership & Workforce Development Faculty Publications

Current learning and development approaches often struggle to capture dynamic individual capabilities, particularly the skills they acquire informally every day on the job. This dynamic creates a significant gap between what traditional models think people know and their actual performance, leading to an incomplete and often outdated understanding of how ready the workforce truly is, which can hinder organizational adaptability in rapidly evolving environments. This paper proposes a novel dynamic learner-state ecosystem—an AI-driven solution designed to bridge this gap. Our approach leverages specialized AI agents, orchestrated via the Model Context Protocol (MCP), to continuously track and evolve an individual’s multi-dimensional …

[Review Of The Book Expanding Approaches To Thematic Analysis: Creative Engagements With Qualitative Data By J. R. Wolgemuth, K. W. Guyotte, & S. A. Shelton (Eds.)], Nazmun Nahar Chaitee

Educational Leadership & Workforce Development Faculty Publications

In Expanding Approaches to Thematic Analysis, editors Jennifer R. Wolgemuth, Kelly W. Guyotte, and Stephanie Anne Shelton introduce an expansive, paradigm-shifting book that reimagines thematic analysis beyond conventional coding methods. This edited volume begins with two presumptions: (1) there are multiple methods of theming data, and (2) qualitative researchers are not necessarily required to code to achieve themes. Through the convergence of various qualitative researchers and early-career scholars, this edited collection pushes thematic analysis into new epistemological territories. The 18 chapters of the book reveal new techniques, such as meditative theming, poetic analysis, and making art, underpinned by theoretical …

Quiet Resistance: Drawing On Covert Advocacy Research To Understand School Leadership Within The Current Anti-Trans Context, Alexandria Gribble, Erica Simpson, Meagan S. Richard

Educational Leadership & Workforce Development Faculty Publications

Over the last few years, there has been a surge in anti-LGBTQIA+ and, specifically, anti-transgender, nonbinary, and gender non-conforming legislation. These laws target the rights of LGBTQIA+ students in K–12 schools, leading to policies censoring gender-inclusive curricula, mandating the outing of students, and restricting transgender students’ access to sports and facilities. The rapid emergence of these bills has outpaced research on how leaders—particularly justice-centred leaders—navigate these hostile policy contexts. Existing research taking a broader lens around leaders’ justice work in schools sheds light on how leaders engage in covert advocacy within complex and constraining contexts. However, understanding how leaders resist …

Why Some Companies Weather Trade Was Better Than Others?, Di Fan, Daphne W. Yiu, Pengcheng Ma, Lin Cui

Research Collection Lee Kong Chian School Of Business

In 2018, the U.S. government levied tariffs affecting more than $250 billion of Chinese products. As a result, many American buyers began turning to alternative suppliers to avoid the significant new costs associated with purchasing from China. Recent research found that transactions between U.S. buyers and Chinese suppliers fell by more than 18% immediately following the start of the trade war. However, the study also found that not all companies were affected equally: Chinese firms that were more innovative or more socially responsible were more likely to retain their U.S. buyers, while buyers were more likely to distance themselves from …

Annual Report 2024-2025, Office Of Sponsored Programs

Annual Reports

No abstract provided.

Demographic Profiles Of San Diego And Imperial Counties, Tessa Tinkler, Eo Hanabusa, Laura Deitrick, Connelly Meschen

Nonprofit Sector Issues and Trends

The Demographic Profiles of San Diego and Imperial Counties provides a snapshot of the two counties' vulnerable populations, including low-income communities, youth, immigrants, refugees, individuals experiencing homelessness, and retirement-age adults. While these counties differ in population size by more than an order of magnitude, the backdrop of California's rising cost of living, shifting immigration policies, income and health disparities, and the projections for an increasing aging population present compounding barriers to financial stability and access to services for all ages. Comprehensive data to understand these community needs was more readily available for San Diego County than Imperial County. This report …

The Effects Of Transcranial Direct Current Stimulation During Extended Reality Exercises For Cortical, Neuromuscular, And Clinical Recovery Of Stroke Survivors, Cassio V.M. Ruas, Bruna M. Carlos, Saulo Feitosa, Márcio Vinícius Silva, Pedro Vazquez, Larissa L. Pontes, Jayne Silvestre, Sara R.M. Almeida, Alexandre F. Brandão, Gabriela Castellano

Research outputs 2022 to 2026

Background: Rehabilitation methods that include anodal transcranial direct current stimulation (atDCS) and extended reality (XR) exercises have been used to enhance neural networks and improve functional performance in stroke patients, but the neuromuscular and neurophysiological mechanisms underlying these improvements are not fully understood. The purpose of this study was to examine the effects of atDCS during XR rehabilitation exercises on cortical, neuromuscular, and clinical outcomes of stroke survivors. Methods: Nineteen chronic stroke survivors were placed into either a transcranial direct current stimulation (tDCS) or a Sham group, without significant (p > 0.73) differences in the baseline levels of disability between groups. …

Sailing Stormy Waters: Leadership And Advocacy In Uncertain Times, Janine Galeski

Faculty Scholarship

In times of uncertainty and rapid change, health care leaders face unique challenges. This article explores best practices for leadership and advocacy in healthcare across five spheres of leadership influence: personal, interpersonal, organization, community, and society. Leaders can reduce the adverse effects of uncertainty by operating within the intersection of evidence-based practice, legal compliance, and ethical decision-making. This article explores practical applications and real-world examples in all 5 spheres of leadership influence.

The Impact Of Data Privacy Concerns On User Trust In Tiktok : A Comparative Study Between The Eu And The Us., Tamta Gachechiladze

Business ETD Collections

This study investigates how data privacy concerns influence user trust in TikTok across two major regions: the European Union (EU) and the United States (US). With over one billion active users worldwide, TikTok has faced intense scrutiny due to its Chinese ownership and concerns over data governance. Using the privacy calculus theory and the Stimulus–Organism–Response (SOR) model as theoretical foundations, the research explores the relationship between privacy concerns, trust, and continued use of TikTok. A mixed-methods approach was applied, combining a literature review with primary survey data collected from 55 valid respondents aged 18–35 across different countries. Findings reveal moderate …

Scrupulosity: A Comprehensive Review Of The Research, Julie M. Painley

Antioch University Dissertations & Theses

This dissertation presents a comprehensive analysis of the current research on scrupulosity, a subtype of obsessive–compulsive disorder (OCD) characterized by intrusive thoughts and compulsive behaviors related to religious and moral concerns. The dissertation identifies key similarities and differences from OCD, and directs focus to thematically related yet unsubstantiated theoretical work in psychology that helps elucidate the core features and etiological factors of scrupulosity as differentiated from other OCD subtypes. The study addresses the critical dearth of research on scrupulosity, aiming to fill significant gaps in the literature regarding its historical context, varied presentation and prevalence in different cultural contexts, and …

Unmasking The Nexus Of Race, Ethnicity, And Health: An Intersectional Analysis Of The Epistemology Of Race In Medicine, Medical Curricula, And Health Disparities, Antoinette Leonard-Jean Charles

Antioch University Dissertations & Theses

The persistent health disparities faced by Black, Indigenous, and People of Color (BIPOC) in the United States are deeply rooted in systemic racism embedded within medical education and clinical practice. Historical acceptance of racial supremacy in the United States has shaped both the foundations and continued practices of medical education, leading to entrenched biases that affect healthcare delivery and patient outcomes. This dissertation critically examines the intersection of race, education, and health by analyzing how historical and contemporary understandings of race and ethnicity shape medical curricula, healthcare practices, and patient care. Through the integration of Critical Race Theory (CRT), Social …

Shaping Leadership: An Autoethnographic Exploration Of Inspirational Moments, Sabine Mathilde Maiberger

Antioch University Dissertations & Theses

Leadership is a complex construct shaped by the interplay of theoretical knowledge and meaningful personal experiences that define us as people. This autoethnographic exploration investigates the question: How have inspirational moments shaped the leader I am today? Understanding how personal experiences influence leaders’ development is critical to leadership studies. To address this, nine of my pivotal life moments were selected and validated through personal artifacts, such as journals and letters, ensuring analytical depth. These moments were analyzed through servant, justice-oriented, and transformational leadership theoretical lenses. The findings revealed eight key lessons: embracing vulnerability, reflective practice, trust-based leadership, advocacy, curiosity, adaptability, …

The Lived Experiences Of Trauma In Autistic Adults: A Thematic Analysis, Briana Trageser

Antioch University Dissertations & Theses

A qualitative research study focused on Autistic adults explored the lived experiences of trauma. Participants included Autistic adults who have either been professionally diagnosed with Autism Spectrum Disorder or who self-identify as Autistic. Data was collected through a survey with 12 open-ended questions. A thematic analysis revealed six themes: (a) adverse childhood experiences, (b) exposure to violence and loss, (c) difficulty relating to others, (d) complex mind and sensory experiences, (e) medical and mental health challenges, and (f) autistic identity. The themes revealed instances of Autistic people experiencing trauma in ways that differ and vary in clinical presentation from their …

Weaving Threads Of Identity: A Qualitative Study On Reconnecting Indigenous Folx, Rachael L. Fuller

Antioch University Dissertations & Theses

This research is a qualitative phenomenological inquiry into reconnecting Indigenous participants’ experiences in how they navigate and integrate their cultural heritage, identity, and intergenerational experiences to shape their present and future lives. Previous literature examines characterizing Indigeneity, navigating multiple spaces, and culture as wellness. Rooted in Tribal Critical Race Theory, semi-structured interviews were conducted with nine participants who self-identified as Indigenous. A thematic analysis highlighted six themes of reconnection: a) oppression, b) ancestors, c) belonging, d) barriers to reconnection, e) learning, and f) connection with community. This research makes a contribution to the growing Indigenous identity literature by providing an …

Mental Heath Experiences Of Transracial Adoptees Of The Global Majority (Black, Indigenous, And People Of Color - Bipoc)., Phebe Brako

Antioch University Dissertations & Theses

This qualitative hermeneutic phenomenological study explores the lived experiences of transracial adoptees of the global majority (BIPOC), focusing on their bicultural identity integration and its impact on mental health. During semi-structured interviews, nine participants shared their stories of navigating cultural and racial dynamics as adoptees in predominantly White adoptive families and communities. The findings revealed six core themes: (1) the Quest for Bicultural Identity Formation, (2) Cultural Integration and Adaptation, (3) Navigating Racial and Cultural Tensions, (4) the Role of Family in Cultural Integration, (5) the Importance of Community and Support Systems, and (6) Mental Health and Therapeutic Experiences, addressing …

A Program Evaluation Of Restorative Storytelling As Professional Development For Waldorf Teachers, David Earl Sewell Mccann

Antioch University Dissertations & Theses

Storytelling, when using the National Storytelling Network’s definition, “the interactive art of using words and actions to reveal the elements and images of a story while encouraging the listener’s imagination,” can be found in most classrooms around the world. If we agree with Walter Fisher and see stories as content with “coherence” and “fidelity” (Fisher, 1987), then much of the communication in classrooms could be considered a form of storytelling. A real question then becomes apparent: why aren’t teachers given extensive training and tools to strengthen their storytelling skills? Restorative Storytelling, a practice I developed out of my years as …

Loving-Learning-Leading-Living: A Scholarly Personal Narrative Of A Black Gay Father, Russell E. Thornhill

Antioch University Dissertations & Theses

This dissertation examines the roles, challenges, and contributions of a Black Gay father, a demographic largely absent from academic discourse. While literature explores themes of the church, LGBTQ+ identities, and social justice, there remains a critical gap addressing the lived experiences of a Black Gay father. This study fills that void by elevating narratives as community activists, family leaders, and clergy members, acknowledging their transformative impact within familial and societal structures. The methodology used is the Scholarly Personal Narrative (SPN). It allows for in-depth, reflective engagement with personal experiences in conversation with scholars while situating them within broader sociocultural, theological, …