Digital Commons Network^™

The Big Four [Accounting] Law Firms: It's Past Time For The Practice Of Law To Get In The Game, Edward S. Adams, John H. Matheson

Articles

New legal services models like ABSs and accommodations like UPL waivers provide multiple positive outcomes. These business structures increase access to legal services, particularly for low and middle-income individuals who are currently priced out of them. By allowing these services to be conducted by nonlawyers, the current supply gap could be closed or completely eliminated. Also, the increased pressure on law firms from corporations and ABSs promotes free market competition. Law firms will be forced to either find a way to differentiate their expertise and services or face a serious threat due to the rejection of the traditional billable hour …

The Ole Miss, University Of Mississippi

The Ole Miss (1897-)

The Ole Miss Annual, 2025

Prisons Are A Public Health Crisis: Alabama Paves The Way, Rae Peeples , '25

Senior Theses, Projects, and Awards

No abstract provided.

Sickle Cell Disease Nursing Education: A Mixed Methods Program Evaluation, Lauren Brooke Clemons

Theses and Dissertations (ETD)

INTRODUCTION AND BACKGROUND: Sickle cell disease (SCD) is a common disorder of the hemoglobin and affects more than 100,000 people in the United States and millions worldwide. In response to a drastic lack of available education a group of SCD experts developed the Sickle Cell Boot Camp to Promote Nursing Excellence Train the Trainer. This initiative provided the first opportunity for nurses worldwide to gain knowledge and skills curated by the leading experts in a safe and interactive environment. By adapting the program to a train the trainer modality, education materials are provided to the attendees, and they are encouraged …

Cholesterol Modulation Of Bk Currents And Cerebral Artery Diameter Via Channel-Forming Alpha-Subunit, Elizabeth Schneider

Theses and Dissertations (ETD)

Voltage- and calcium-gated, large conductance potassium channels (BK; MaxiK) are ubiquitously expressed and subsequently mediate numerous physiological processes. Cholesterol is consumed in high amounts with the diet and accumulates in cellular membranes when plasma levels become elevated. Cholesterol is a known inhibitor of BK channels and is suspected of contribution to many pathophysiological issues via its interaction with these channels. However, the molecular mechanisms that drive cholesterol inhibition of BK channels remain largely unexplored. This dissertation hypothesized that cholesterol inhibits BK currents via binding to specific amino acid(s) of the channel-forming alpha subunit, and involving distinct modifications of channel gating. …

Sars-Cov-2 Variants Of Concern: Biological Implications Of Immunogenicity And Comorbidity, Jacob Nichols

Theses and Dissertations (ETD)

When coronavirus disease 2019 (COVID-19) emerged in human populations in late 2019, there was nothing known about the virus, SARS-CoV-2, besides that it had a high degree of similarity to severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). The prior published research on these viruses set a strong foundation for the research approaches needed to quickly stand-up medical countermeasures for treatment of COVID-19. However, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) soon revealed a high propensity to evolve new variants that could engage host cell receptors with greater affinity and escape host immunity. With each wave …

Integrative Approaches In Colorectal Cancer: Prognostic Biomarkers And Ai-Driven Hypothesis Generation For Early Diagnosis And Drug Resistance, Heliang Yin

Theses and Dissertations (ETD)

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with early diagnosis being critical for improving patient outcomes. This study addresses two key aspects of CRC research: understanding its etiology and prognostic biomarkers and exploring the role of artificial intelligence (AI) in generating hypotheses for early diagnosis. In the first project, we analyzed prognostic biomarkers in CRC, revealing a significant negative correlation between TP53 and CD56 mutations, which have opposing effects on patient survival. TP53, a tumor suppressor gene, is frequently mutated in CRC, while CD56, a glycoprotein involved in cell adhesion, may act as a cancer enhancer. …

Synthesis And Design Of Clpp Activators As Novel Antibiotics, Schyler Odum

Theses and Dissertations (ETD)

Purpose. Design and synthesize novel compounds to treat Staphylococcus aureus infections by targeting the dysregulation of the Casein Protease P, ClpP. Methods. Utilize established chemical methods to synthesize ureadepsipeptides, small-molecule ClpP activators, and ureadepsipeptide hybrids. Assess their effectiveness by using minimum inhibitory concentration assays and in vitro biochemical assays for ClpP activation. Explore their potential as antibiotics through mitochondrial toxicity tests, glucose/galactose assays, and biophysical measurements related to metabolism and clearance, including thermal shift and surface plasmon resonance assays. Results. Synthesized and tested 33 novel compounds, comprising a total of 80 synthetic steps. Conclusion. The three-part conclusion from the dissertation …

Characterization Of Novel Hantaviruses In Paraguay, Ifebuche Nnamani

Theses and Dissertations (ETD)

The genus Orthohantavirus, is a group of tripartite, negative-sense RNA viruses of which some members are the etiologic agents for hemorrhagic fever with renal syndrome (HFRS) or orthohantavirus cardiopulmonary syndrome (HCPS) in the Old and New Worlds, respectively. Sampling of wild rodents for these viruses has increased our knowledge of their host range and continues to lead to the discovery of new orthohantaviruses species and strains. HFRS and HPS have case fatality rates of up to 15% and 40%, respectively. And in some years, morbidity rates of up to 100,000 cases can be reached, globally. The epidemiological evidence of human-to-human …

Utilization Of Model-Based Approaches To Maximize Efficacy Of Antibiotics For The Treatment Of Mycobacterium Abscessus Pulmonary Infection, Hyunseo Park

Theses and Dissertations (ETD)

Prevalence and incidence of Mycobacterium abscessus (Mab) pulmonary infections have increased and been recognized as a major cause of mortality, particularly in certain patient populations, such as cystic fibrosis (CF) patients. Due to the intrinsic multidrug resistance mechanisms and biofilm (BF) formation properties of Mab, effective treatment remains challenging, as these factors significantly diminish the antibacterial activity of drugs. Current treatment guidelines recommend prolonged therapy, generally more than 12 months with a multidrug combination of at least four agents. However, no optimal combination, regimen, or treatment duration has been universally established for Mab pulmonary infections (Mab-PI). Therefore, the selective and …

Protein Kinase D1 In Myeloid Cells Promotes Disease Progression And Severity In S. Rectivirgula Induced Hypersensitivity Pneumonitis, John David Snyder

Theses and Dissertations (ETD)

Introduction: Hypersensitivity pneumonitis (HP) is an inflammation driven interstitial lung disease characterized by inflammation of the interstitium, bronchioles, and alveoli of the lung that leads to granuloma formation. Myeloid lineage immune cells play a critical role in the early and late stages of the disease, and this activity is mediated through toll-like receptors (TLRs) expressed by these cells. Protein kinase D1 (PKD1) has previously been identified as a critical signaling molecule in the TLR signaling pathways of all TLR family members except for TLR3. Our previous research found that activation of protein kinase D1 (PKD1) in the lungs following exposures …

Incorporating Social Determinants Of Health Into A Screening Tool Using Machine Learning To Predict Lung Cancer Diagnosis Among High Risk Patients, Bianca Jackson

Theses and Dissertations (ETD)

This research aims to assess the impact of incorporating social determinants of health (SDoH) into prediction screening models for predicting lung cancer among high risk-patients. Lung cancer is typically diagnosed at a later stage when surival and health outcomes are poor. Screening guidelines are currently in place; however, patients at high risk can be missed. There is a need for short-term predictions, to better identify patients at an earlier stage. SDoH features, such as socioeconomic satus, can provide social context that improves identification of patients who might have otherwise been overlooked. The proposed framework includes developing an early detection tool …

Cook Martin Poulson, P.C. V. Daniel G. Smith, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Reply Brief of Appellant
/="/"> On appeal from the Second Judicial Court, Weber County,
/="/"> Honorable Cristina Ortega, District Court No. 220903740

Hay Comida En La Casa: Study On Food Inaccessibility In Nyc, Crystal A. Secaira , '25

Senior Theses, Projects, and Awards

No abstract provided.

Teachers’ Perspectives On Behavioral Classroom Expectations Of Students With Emotional And Behavioral Disorders, Jennifer E. Brewer

Theses and Dissertations

The problem addressed in this study was that adolescents with emotional and behavior disorders (EBD) were failing in general education courses. The purpose was to investigate how teachers’ perceptions and biases influenced EBD students. Participants included five teachers (two special education teachers and three general education teachers) from each of Grades 6, 7, and 8 recruited from social media. The study was guided by the case study research design, and the interview instrument was the Indepth Interview Protocol. Data analysis was guided by a coding system that facilitated searching the interview responses for themes.

Research Question 1 queried about forms …

Teacher Perception On The Implementation Of A Culturally Responsive Ela Curriculum, Erica Tate Dial

Theses and Dissertations

While the principles of culturally responsive and culturally relevant teaching hold transformative potential, they can only be fully realized if educators are genuinely equipped and empowered to implement them. This qualitative study examined teacher perceptions of an English Language Arts curriculum through the lens of culturally relevant and culturally responsive teaching. A diverse group of teachers, varying in experience, age, gender, and race, were interviewed to gather a range of perspectives on the implementation of this curriculum. The study focused on addressing the following research questions: 1. What are teachers’ perceptions of culturally responsive and culturally relevant instruction and academic …

Operationalizing Intersectionality Analysis For Urban Agriculture In Quito, Ecuador, Laine N. Young

Theses and Dissertations (Comprehensive)

This thesis outlines the results of a case study in Quito, Ecuador with the municipally led participatory urban agriculture project, AGRUPAR, an internationally recognized project that promotes women’s empowerment, traditional knowledge, agroecology, and livelihoods. It works to improve the lives of those experiencing high levels of poverty in Quito. This dissertation applies an intersectional analysis to urban agriculture research to enhance attention to power relations, social justice, and equity within its scholarly and practical realms. Intersectionality is an understanding that people have unique experiences of oppression based on their unique social location (what intersecting social categories they belong to) and …

The Perceived Frequency And Effects Of Multilingual Communication In Youth And Adolescent Soccer, Simao M. Araujo

Theses and Dissertations (Comprehensive)

In professional soccer, the topic of multilingual communication has been widely researched; however, there appears to be a gap in the literature concerning how multilingual use is perceived by athletes and coaches at the youth and adolescent level of the sport. In the present study, male soccer athletes ages 10 to 18 years old and their coaches completed a questionnaire in which they rated both perceived frequency of use and perceived effects of using multilingual communication in youth and adolescent soccer. Specifically, these questionnaires elicited quantitative information regarding categories such as tactical advantages, words of encouragement, general expressions, and group …

Special-Purpose Governments, Conor Clarke, Henry Hansmann

Scholarship@WashULaw

When one thinks of government, what comes to mind are familiar general-purpose entities like states, counties, and cities. But more than half of the 90,000 governments in the United States are strikingly different: They are “special-purpose” governments that do one thing, such as supply water, fight fire, or pick up the trash. These entities have expanded far more rapidly than any other form of government. Yet they remain understudied, and they present at least two puzzles. First, special-purpose governments are difficult to distinguish from entities that are typically regarded as business organizations—such as consumer cooperatives—and thus underscore the nebulous border …

Venturing Into Health, Rachel Sachs

Scholarship@WashULaw

In recent years, the landscape of venture capital (VC) investment in healthcare technologies has been altered by the introduction of new types of VC firms: those that have emerged from hospital systems and health insurers. However, the legal literature has not yet analyzed these new VC firms, the role they may play in healthcare innovation, and how innovation law and policy ought to consider their involvement. Hospital system and health insurer VC firms operate very differently than do traditional VC firms, even those that have historically developed healthcare specializations. Instead of simply investing capital into start-up firms, hospital system and …

A New Framework For Drug Pricing Law And Policy, Rachel Sachs

Scholarship@WashULaw

Scholars and policymakers have expressed concern about the impact of high prescription drug costs on patients and healthcare budgets. This Article presents a new theoretical framework for evaluating both the problem to be addressed by drug pricing reforms as well as the efficacy of potential solutions. In seeking to solve “the drug pricing problem,” our legal system has given primacy to competition rather than regulation to drive down drug prices. This Article disaggregates the broader concept of “the drug pricing problem” into four steps, each of which must be addressed and each of which elevates different institutional actors to key …

Algorithmic Governance And Nondiscrimination Rights In The Workplace, Pauline Kim

Scholarship@WashULaw

This chapter analyzes existing legal responses to the problem of discriminatory algorithms in the workplace. As firms increasingly rely on algorithms or automated decision systems, a type of artificial intelligence, to manage their workforces, concerns have grown that these tools can systematically exclude historically disadvantaged groups. One response is to rely on traditional anti-discrimination law. These laws clearly prohibit certain forms of algorithmic discrimination; however, the complex, opaque nature of algorithms makes identifying and proving discriminatory harms challenging. Another response looks to broader frameworks of data protection and algorithmic regulation to protect against workplace discrimination. These initiatives are promising, but …

Measuring Income And Income Inequality, Conor Clarke, Wojciech Kopczuk

Scholarship@WashULaw

Income inequality is important, but attempts to measure it arrive at strikingly different conclusions. Why? We use recent disputes over measuring United States income inequality to return to first principles about both the income concept and inequality measurement. We emphasize two broad points. First, no measure of the income distribution is truly comprehensive, or could attempt to be comprehensive without making controversial choices. We document the practical and conceptual problems that the standard ideal—comprehensive Haig-Simons income—raises. Second, much of the controversy in this area turns on the many tradeoffs between starting with individual tax data versus more expansive income concepts. …

Defending Battered Survivors With Brain Injuries: An Educational Guide For Advocates In North Carolina, Kelly Newcomb

Campbell Law Review

In the 1980s, the concept of "Battered Woman Syndrome" (BWS) was introduced into U.S. courtrooms, typically as a defense in homicide cases where survivors of intimate partner violence (IPV) killed their abusers. Traditional BWS theories largely center around psychological not physiological impacts of IPV Since then, researchers have begun to recognize the prevalence of brain injuries (BIs) in IPV survivors.

While most BI research centers around male subjects, emerging studies suggest that the effects of BI may be especially severe in women IPV survivors due to anatomical, hormonal, psychological, and socio-economic factors. These developments may support decreased culpability for female …

Child Abuse By Serious Emotional Damage: An Invitation For Repulsive Arguments, George Sparks Bennett

Campbell Law Review

The purpose of this Comment is to call attention to the need to eliminate the definition of "serious emotional damage" as defined in North Carolina General Statutes section 7B-101(1)(e). This Comment uses a recent case from the North Carolina Court of Appeals and the ensuing denial of a petition for discretionary review by the Supreme Court to highlight how the statute invites parents to argue, in matters as sensitive and awful as child abuse, that the emotional damage inflicted upon a child is not severe enough. This Comment discusses the procedural processes for investigating instances of reported child abuse and …

Affirming Independent Judgment: The End Of Agency Deference In North Carolina, Jake Parker

Campbell Law Review

In the summer of 2024, the Supreme Court of the United States overturned the Chevron doctrine, which required federal courts to defer to agency interpretations of ambiguous statutes. While the debate about agency deference in federal litigation generated significant attention in the legal community and from media outlets, the use of agency deference in state courts has received relatively little fanfare. This Article examines how the concept of agency deference entered North Carolina's administrative law jurisprudence and the North Carolina Supreme Court's recent efforts to reject the use of deference in the state's courts. This Article supports the court's project …

Tides Of Power: Coastal Conservation Association V. State And The Clash Of Environmental Rights, Legislative Authority, And Judicial Limits In North Carolina, Dylan Long

Campbell Law Review

Environmental policy in North Carolina has primarily been within the discretion of the General Assembly. There has been little judicial determination as to what duty, if any, the state has in maintaining its natural resources for public use. North Carolina courts have provided limited judicial input on the General Assembly’s minimum, constitutionally required duty to protect the state’s natural resources. The courts’ sparse decisions have been inconsistent on what the legislature’s minimal obligations are. A recent and ongoing case has brought this issue to a head. The courts will soon be required to rule on the merits of this issue, …

Incitement, Enthusiasm, And The Dangers Of Negligent Protest, John D. Inazu

Scholarship@WashULaw

This Article explores the murky line between protected speech and assembly on the one hand, and harmful incitement on the other. On the occasion of the 100th anniversary of Oliver Wendell Holmes’s dissent in Gitlow v. New York, it explores Holmes’s famous dictum that “every idea is an incitement” as a conceptual starting point. By analyzing the relational and temporal dynamics between speaker and listener, the Article highlights how meaning and effect are often shaped by the listener’s agency and other circumstances beyond the control of the speaker. Two contemporary cases illustrate these dynamics. The first is the Fifth Circuit …

Ai Ethics, Law, And Policy, Pauline Kim, Ryan Durrie

Scholarship@WashULaw

AI technologies promise many benefits, but they can also have significant negative impacts on human health, safety, well-being, and fundamental rights. This chapter explores the different governance tools that have been considered for guiding developments in AI in socially beneficial ways, examining the relevance of ethics, law, and policy. Each of these approaches offer tools to address these concerns; however, each has limitations, and none provides a complete solution in itself. Statements of ethical principles can articulate high-level values and goals to guide behavior but are usually quite vague and difficult to operationalize. They also lack any enforcement mechanism. In …

Lessons Learned From The Trump Rule Of Law Stress Test: Beware Bad Faith Actors, Brian Z. Tamanaha

Scholarship@WashULaw

The second Trump Administration has engaged in a vast swath of actions that press against the outer boundaries of legality. These actions provide a unique opportunity to identify potential vulnerabilities and expose how the rule of law can be undermined. While I will elucidate well-known points along the way, my primary aim is to bring out aspects of the rule of law that usually go unnoticed or under the radar. After setting out basic aspects of the rule of law, I cover three topics: 1) adhering to the truth, 2) pretextual arguments, and 3) flooding the field with actions and …