“Take Eight Bits And Call Me In The Morning” Video Games, Well-Being, And The Psychology Of Nostalgia, Nicholas Bowman

Media Studies - All Scholarship

For nearly 60 years, video games have arrested the attention of players, inviting us to interact and interface with on-screen content. More than just short-term entertainment experiences, video games are part of a broader cultural milieu—they are the most profitable media entertainment sector (global revenues nearly $400 billion USD in 2023) with more than 3.5 billion players globally (Clement, 2023). Similar to other entertainment media, some video game intellectual properties have transcended generations and, in many cases, grown beyond the medium itself: common cultural touchstones include Super Mario Bros. and Sonic the Hedgehog, along with seemingly endless subcultures of devoted …

What Lawyers Could Learn From The Corporate Practice Of Medicine, Melissa D. Mortazavi

Faculty Articles

Proponents of the United States’ domestic experiments in non-lawyer ownership (NLO) of legal practice justify them in terms of increasing “access to justice.” But what if opening ownership of legal practice to investment capital only exacerbates market failures (leading to further consolidation and increased costs to clients), while also compromising professional autonomy and fiduciary duty? The legal profession must be clear-eyed about who are the real winners and losers of such a shift and avoid being blinded by wishful thinking. Prominent legal scholars have repeatedly touted NLO as a solution to the access to justice crisis. However, there is scant …

Artificial Intelligence And The Hipaa Privacy Rule: A Primer, Stacey A. Tovino

Faculty Articles

No abstract provided.

The First Amendment, Global Corporate Responsibility Standards, & The Quest For Online "Speech Nirvana", Evelyn Aswad

Faculty Articles

With large and powerful social media companies operating as worldwide speech regulators, it is unsurprising that governments have attempted to not only regulate how these companies address platform speech but also pressure them to deliver preferred speech outcomes. In 2024, the Supreme Court decided two cases addressing both themes in the U.S. context. In Moody v. NetChoice, the Court explained how legislation regulating private platform curation of usergenerated content runs afoul of First Amendment protections. And, in Murthy v. Missouri, the Court appeared to erect significant hurdles to challenging alleged governmental coercion of such platforms. These cases have left many …

Insider Trading & Unconstitutionally Complelled Speech, Steven J. Cleveland

Faculty Articles

The Supreme Court has recently weaponized the First Amendment to invalidate economic regulations. Consequently, the Court’s current analytical framework risks invalidating as unconstitutional certain speech compelled by Congress and the SEC to combat insider trading.

The government may compel speech to combat fraud, and many courts and commentators view insider trading as a fraud against the counterparty to the insider’s trade. Today, the government primarily resorts to Section 10(b) of the Securities Exchange Act of 1934 and its implementing regulations, including Rule 10b-5, to combat insider trading. Those regulations prohibit deceptive conduct and do not directly compel speech. Interestingly, in …

In Defense Of Pardons, Stephen E. Henderson

Faculty Articles

Pardons by the past two U.S. presidents—one Democratic and one Republican—have caused some to question the wisdom of executive clemency. American criminal justice is imperfect, such critics of course recognize, but here the cure might be worse than the disease. If pardons have become the playthings of would-be monarchs and tyrants, perhaps it is time to let them go. As a strong proponent of role-reversible criminal justice, I am sympathetic to this view—even in mercy, why is the decision of the single elite supplanting the will of the people? Still, I write in pardons’ defense. Not only are pardons an …

Undocumented Eldercare, Llc, Kit Johnson

Faculty Articles

Americans are aging. Within five years, 20% of the U.S. population will be over the age of 65. In the next 25 years, the number ofcitizens over the age of 80 is expected to triple.

Many older Americans, particularly the oldest, need help with daily lifeeverything from dressing and showering to cooking and cleaning. Assistance, however, is hard to come by. At-home caregivers are expensive. Institutional settings, also expensive, are routinely understaffed.

Thousands of noncitizens provide eldercare in home and institutional settings. Many of these noncitizens have work authorization pursuant to Temporary Protected Status (TPS), an immigration program that President …

High Crimes In Low Airspace: The Rise Of Drones In Cross-Border Drug Trafficking, Hannah Haight

Journal of Air Law and Commerce

Can the United States effectively regulate its airspace when criminal actors exploit it without entering traditional territorial channels? Mexican drug trafficking organizations increasingly deploy drones to deliver narcotics across the U.S.–Mexico border. These flights often occur at low altitudes, at night, and in remote areas, which renders them nearly undetectable by conventional enforcement methods. Yet, no statute squarely addresses the use of drones in cross-border drug trafficking. The Federal Aviation Administration (FAA) regulates drones under the FAA Modernization and Reform Act of 2012, but its mandate is safety, not interdiction. The result? A growing technological asymmetry: criminal cartels innovate, while …

Arh 167 Tradition And Innovation In The Art Of The West (Introductory Art History Course), Sharon L. Jordan

Open Educational Resources

In this OER section of the course Tradition and Innovation in the Arts of the West, students will be introduced to arts of different styles and time periods spanning the ancient world to the beginning of the modern era focusing mainly on the development of Western art within a global context.

Spatiotemporal Land Use Changes Dynamics Impacts On Natural Reserves In West African Dryland: Drivers, Carbon Emissions And Climate Change Implications, Issaka Abdou Razakou Kiribou, Kangbéni Dimobe, Charles Lamoussa Sanou, Sintayehu W. Dejene

All Rsif Scholars' Publications

Land use change (LUC), primarily driven by anthropogenic pressure, poses a major threat to West African drylands’ vegetation. As critical indicators of ecosystem sustainability, LUC patterns reflect how human activities alter carbon dynamics and climate vulnerability. This systematic review analyzes the spatial and temporal dynamics of LUC impacts on natural reserves. Using targeted keywords, 18 peer-reviewed articles and institutional reports were synthesized to assess LUC patterns, identify key biophysical and socio-economic drivers, and evaluate carbon and climate implications. Findings show substantial losses of natural ecosystems due to land conversion, deforestation, and soil degradation. Between 1975 and 2013, Sahelian savanna, woodland, …

Energy Efficiency In The Building Sector In Burkina Faso: Literature Review, Swot Analysis, And Recommendations, Bazam Amonet Ouoba Nebie, Abdou Lawane, Césaire Hema, Monica Siroux

All Rsif Scholars' Publications

In Burkina Faso, increasing access to electricity requires the optimized management of energy consumption in buildings and the implementation of regional and national regulations. These regulations have been implemented to promote energy efficiency in the building sector. However, they do not yet seem to have produced the expected results. Conducting a study could help identify the shortcomings related to energy efficiency and guide future research toward sustainable solutions. To date, no such study has been carried out. Therefore, this research aims to analyze the causes of these shortcomings, understand the gaps in the literature, and identify prospects for implementing energy …

Assessment Of Bio-Security Knowledge, Attitude And Hygienic Practices Among Smallholder Chicken Farmers In Southern Mozambique, Noémia André Mugabe, Jamal Kussaga, Abdulsudi Issa-Zacharia

All Rsif Scholars' Publications

The production of broiler chickens in intensive systems struggles to maintain hygiene in production, despite contributing to combating malnutrition, generating employment, and increasing family income, especially in developing countries. Using a structured questionnaire survey, a cross-sectional study was carried out among 395 smallholder farmers to evaluate their knowledge, attitudes, and practices related to farm biosecurity in urban and peri-urban areas of Mozambique and determine the factors affecting KAP (knowledge, attitude, and practice) levels. Data were analyzed using Statistical Package for Social Science (SPSS) (IBM version 27). The findings indicate that education level and training significantly influence (p < 0.001) food safety in terms of biosecurity knowledge, attitudes, and practices. Smallholders who attended food safety training exhibited positive attitudes (95.5%, mean score of 89.71 ± 10.1) in contrast to those who did not participate in training (74.8%, mean score of 79.91 ± 9.68). Additionally, washing hands with soap before and after using the toilet and wearing protective clothing during chicken husbandry were significantly associated with education level (χ² = 15.345, P = 0.018); those with informal education were 34% less likely to have a negative attitude toward food safety compared to those with high education. A significant correlation (p < 0.01) was observed between residence area, training, and biosecurity knowledge, attitude, and practice. Because smallholders lack training, hygiene expertise, and biosecurity practices on their farms, this study concluded that they pose a risk to public health and food safety. To maintain consumer health and guarantee food safety, farmers should properly dispose of waste, including dead chickens, and receive continuous training in excellent biosecurity measures on the farm

Almanet: A Hybrid Online Learning Ids For Real-Time Iot Security, Promise Ricardo Agbedanu, Shanchieh (Jay) Yang, Richard Musabe, Ignace Gatare, James Rwigema

All Rsif Scholars' Publications

Although some modern Intrusion Detection Systems (IDSs) for Internet of Things (IoT) have explored online machine learning (ML) approaches to build these IDSs, most IoT-based IDSs are designed using offline ML techniques. IDSs built with offline ML approaches cannot adapt to rapidly changing IoT network conditions. They need continuous retraining and require a lot of computational power. To address these limitations, we propose ALMANET (ALMA+NET), a hybrid intrusion detection approach combining Approximate Large Margin Algorithm (ALMA) with Stochastic Weight Averaging (SWA) and an online neural network (NET). ALMANET leverages the power of online learning, which updates models incrementally and allows …

Antibiotic Use And Antimicrobial Resistance: Knowledge, Attitudes, And Practices Among Smallholder Chicken Farmers In Southern Mozambique, Noemia Andre Mugabe, Jamal Kussaga, Abdulsudi Issa-Zacharia

All Rsif Scholars' Publications

Intensive production systems face challenges in treating individual chickens due to the large number of animals, resulting in the indiscriminate use of antibiotics as the only alternative. The use of antibiotics in poultry production has adverse effects on humans, as prolonged consumption of contaminated meat can lead to the development of antibiotic resistance in intestinal bacteria. A cross-sectional survey involving 395 smallholder farmers was conducted through face-to-face interviews to assess knowledge, attitudes, and practices (KAP) regarding antibiotic use in urban and peri-urban areas of Southern Mozambique. Data were analyzed using SPSS version 27. The findings revealed that 60% of respondents …

Clinical Application Of Chambo Tilapia Fish Skin Xenograft For Skin Tissue Regeneration: A Case Report In A Partial-Thickness Burns Pediatric Patient, Bhahat Lawlley Zimba, Dennis Mtunduwatha, David Hara, Mukondwedi Mchazime, Aaron Stima, Mwemezi Rwiza, Elingarami Sauli

All Rsif Scholars' Publications

WHO reports that burns account for more than 180,000 deaths annually with the majority of cases coming from low and middle-income countries due to limited resources in the management of burns. Currently, burns are being treated using silver sulphadiazine and gauze dressings, but this method has demonstrated to have some shortfalls. Alternative methods are being researched to find a better treatment modality with a faster healing duration. This case report describes the novel application of Chambo tilapia (Oreochromis lidole) fish skin xenograft in the treatment of partial thickness burns in a patient. The research was conducted on a 5-year-old female …

Trend Analysis Of Rainfall And Temperature In Metuge District, Northern Mozambique, Heraclito Rodrigues Comia, Fekadu Beyene Kenee, Fred Charles Nelson, Janete Mutualbo Americano, Serafino Afonso Rui Mucova

All Rsif Scholars' Publications

Climate change poses significant economic, social, political and environmental challenges, with impacts varying depending on the geographical location and adaptive capacity. This study addresses data gaps by analyzing long-term trends in rainfall and temperature in the Metuge district from 1989 to 2022. The Mann–Kendall trend test, a non-parametric method, was used to detect trends, while Sen’s slope estimator quantified the magnitude of these trends. The seasonal analysis differentiated trends between the rainy season (October to March) and the dry season (April to September). The Mann–Kendall test revealed a decrease in overall annual rainfall and dry season rainfall, with a decrease …

Smallholder Farmers’ Livelihood Vulnerability To Climate Change In Metuge District, Northern Mozambique, Heraclito Rodrigues Comia, Fekadu Beyene Kenee, Fred Charles Nelson, Serafino Afonso Rui Mucova

All Rsif Scholars' Publications

Paper • The following article is Open access

Smallholder farmers’ livelihood vulnerability to climate change in Metuge district, Northern Mozambique

Heráclito Rodrigues Comia, Fekadu Beyene Kenee, Fred Charles Nelson and Serafino Afonso Rui Mucova

Published 13 June 2025 • © 2025 The Author(s). Published by IOP Publishing Ltd Environmental Research Communications, Volume 7, Number 6Citation Heráclito Rodrigues Comia et al 2025 Environ. Res. Commun. 7 065014DOI 10.1088/2515-7620/ade123

Download Article PDF

Article metrics

438 Total downloads

Submit

Submit to this Journal

Share this article

Abstract

Introduction. Mozambique is one of the country’s most vulnerable to climate …

Identification Of Potential Vectors And Detection Of Rift Valley Fever Virus In Mosquitoes Collected Before And During The 2022 Outbreak In Rwanda, Isidore Nsengimana, Emmanuel Hakizimana, Jackie Mupfasoni, Jean Nepomuscene Hakizimana, Augustino A. Chengula, Christopher J. Kasanga, Gillian Eastwood

All Rsif Scholars' Publications

Rift Valley fever virus (RVFV) is an emerging mosquito-borne arbovirus of One Health importance that caused two large outbreaks in Rwanda in 2018 and 2022. Information on vector species with a role in RVFV eco-epidemiology in Rwanda is scarce. Here we sought to identify potential mosquito vectors of RVFV in Rwanda, their distribution and abundance, as well as their infection status. Since an outbreak of RVF occurred during the study period, data were obtained both during an interepidemic period and during the 2022 Rwanda RVF outbreak. Five districts of the eastern province of Rwanda were prospected using a combination of …

Advancing Sustainable Practices: Integrated Pedological Characterization And Suitability Assessment For Enhanced Irish Potato Production In Tsangano And Angónia Districts Of Tete Province, Mozambique., Tamara Jose Sande, Balthazar Michael Msanya, Hamisi Juma Tindwa, Alessandra Mayumi Tokura Alovisi, Johnson M. Semoka, Mawazo Shitindi

All Rsif Scholars' Publications

Irish potato (Solanum tuberosum) is a critical crop for food security and economic growth in Tsangano and Angónia Districts, Central Mozambique. Challenges like inconsistent yields and variable quality are often linked to suboptimal soil conditions, which limit production. This study aimed to classify and evaluate the suitability of soils for potato cultivation in Tete Province, where detailed soil assessments remain limited. Four pedons—TSA-P01 and TSA-P02 in Tsangano and ANGO-P01 and ANGO-P02 in Angónia—were examined for bulk density, texture, pH, organic carbon, and nutrient content using a combination of pedological methods and laboratory soil analysis. To determine each site’s potential for …

Fermentation, Handling And Claimed Therapeutic Effects Of Dhanaan: An Ethiopian Fermented Camel Milk, Tiruha Habte Karssa, Jamal B. Kussaga, Teresa Lemsaddek Lemsaddek, Jovin K. Mugula

All Rsif Scholars' Publications

Dhanaan is a spontaneously fermented camel milk that is popular in the Somali regional state of Ethiopia and plays a sig- nificant role in the livelihoods of pastoral communities. This study aimed to investigate traditional fermentation methods of dhanaan in these communities. Four districts, namely, Gursum, Shabelle, Degehabur, and Birqot, were purposively selected on the basis of camel rearing, camel milk production, and consumption. A cross-sectional survey of traditional fermentation methods, handling, utilization, and the claimed therapeutic effects of dhanaan was conducted using both open- and closed- ended questions in the districts. The traditional preparation of dhanaan involves spontaneous fermentation …

Ganglioside Gd2 Contributes To A Stem-Like Phenotype In Intrahepatic Cholangiocarcinoma, Antonella Mannini, Mirella Pastore, Alessia Giachi, Margherita Correnti, Elena Spínola Lasso, Tiziano Lottini, Benedetta Piombanti, Ignazia Tusa, Elisabetta Rovida, Cédric Coulouarn, Jesper B Andersen, Monika Lewinska, Claudia Campani, V Lokesh Battula, Bin Yuan, Massimo Aureli, Emma V Carsana, Caterina Peraldo Neia, Paola Ostano, Alessia Tani, Daniele Nosi, Anna Vanni, Laura Maggi, Luca Di Tommaso, Giuseppina Comito, Stefania Madiai, Annarosa Arcangeli, Fabio Marra, Chiara Raggi

Faculty, Staff and Student Publications

BACKGROUND & AIMS: GD2, a member of the ganglioside (GS) family (sialic acid-containing glycosphingolipids), is a potential biomarker of cancer stem cells (CSC) in several tumours. However, the possible role of GD2 and its biosynthetic enzyme, GD3 synthase (GD3S), in intrahepatic cholangiocarcinoma (iCCA) has not been explored.

METHODS: The stem-like subset of two iCCA cell lines was enriched by sphere culture (SPH) and compared to monolayer parental cells (MON). GS profiles were evaluated by chromatography, after feeding with radioactive sphingosine. Membrane GD2 expression was evaluated by FACS, and the expression of enzymes of GS biosynthesis was analysed by RT-qPCR. The …

Ft538, Ipsc-Derived Nk Cells, Enhance Aml Cell Killing When Combined With Chemotherapy, Amanda Eckstrom, Anudishi Tyagi, Sajid Mahmood, Lilly Wong, Bahram Valamehr, Adishwar Rao, Akriti Agrawal, Maryam Siddiqui, V Lokesh Battula

Faculty, Staff and Student Publications

Induced pluripotent stem cell (iPSC)-derived natural killer (NK) cells offer an opportunity for a standardized, off-the-shelf treatment with the potential to treat a wider population of acute myeloid leukaemia (AML) patients than the current standard of care. FT538 iPSC-NKs express a high-affinity, noncleavable CD16 to maximize antibody dependent cellular cytotoxicity, a CD38 knockout to improve metabolic fitness, and an IL-15/IL-15 receptor fusion preventing the need for cytokine administration, the main source of adverse effects in NK cell-based therapies. Here, we sought to evaluate the potential of FT538 iPSC-NKs as a therapy for AML through their effect on AML cell lines …

Development And Validation Of Natural Language Processing Algorithms In The National Enact Network, Yanshan Wang, Jordan Hilsman, Chenyu Li, Michele Morris, Paul M Heider, Sunyang Fu, Min Ji Kwak, Andrew Wen, Joseph R Applegate, Liwei Wang, Elmer Bernstam, Hongfang Liu, Jack Chang, Daniel R Harris, Alexandria Corbeau, Darren Henderson, John Osborne, Richard E Kennedy, Nelly-Estefanie Garduno-Rapp, Justin F Rousseau, Chao Yan, You Chen, Mayur B Patel, Tyler J Murphy, Bradley A Malin, Chan Mi Park, Jungwei W Fan, Sunghwan Sohn, Sandeep Pagali, Yifan Peng, Aman Pathak, Yonghui Wu, Zongqi Xia, Salvatore Loguercio, Steven E Reis, Shyam Visweswaran

Faculty, Staff and Student Publications

Objective: Electronic Health Record (EHR) data are critical for advancing translational research and AI technologies. The ENACT network offers access to structured EHR data across 57 CTSA hubs. However, substantial information is contained in clinical narratives, requiring natural language processing (NLP) for research. The ENACT NLP Working Group was formed to make NLP-derived clinical information accessible and queryable across the network.

Methods: We established the ENACT NLP Working Group with 13 sites selected based on criteria including clinical notes access, IT infrastructure, NLP expertise, and institutional support. We divided sites into five focus groups targeting clinical tasks within disease contexts. …

Epidemiology Of Patient Record Duplication, Onur Sahin, Audrey Zhao, Reuben Joseph Applegate, Todd R Johnson, Elmer V Bernstam

Faculty, Staff and Student Publications

Objectives: Duplicate patient records can increase costs and medical errors. We assessed the association between demographic factors, comorbidities, health care usage, and duplicate electronic health records.

Methods: We analyzed the association between duplicate patient records and multiple demographic variables (race, Hispanic ethnicity, sex, and age) as well as the Charlson Comorbidity Index (CCI), number of diagnoses, and number of health care encounters. The study population included 3,018,413 patients seen at a large urban academic medical center with at least one recorded diagnosis. Duplication of patient medical records was determined by using a previously validated enterprise Master Person Index.

Results: Unknown …

Quantitatively Assessing The Impact Of The Quality Of Snomed Ct Subtype Hierarchy On Cohort Queries, Xubing Hao, Xiaojin Li, Yan Huang, Jay Shi, Rashmie Abeysinghe, Cui Tao, Kirk Roberts, Guo-Qiang Zhang, Licong Cui

Faculty, Staff and Student Publications

Objective: SNOMED CT provides a standardized terminology for clinical concepts, allowing cohort queries over heterogeneous clinical data including Electronic Health Records (EHRs). While it is intuitive that missing and inaccurate subtype (or is-a) relations in SNOMED CT reduce the recall and precision of cohort queries, the extent of these impacts has not been formally assessed. This study fills this gap by developing quantitative metrics to measure these impacts and performing statistical analysis on their significance.

Material and methods: We used the Optum de-identified COVID-19 Electronic Health Record dataset. We defined micro-averaged and macro-averaged recall and precision metrics to assess the …

Building Patient-Facing Technology: A Redcap-Based Approach, Yuheng Shi, Eric Yang, Katie Gahn, Heidi Mason, Yun Jiang, Yang Gong

Faculty, Staff and Student Publications

This work describes the architecture design of a patient-facing technology (PFT) based on the Research Electronic Data Capture (REDCap) platform and other tools to support cancer patients in self-tracking and managing medication concerns and symptoms during transitions of care. The design is guided by the Chronic Care Model (CCM) and User-Centered Design (UCD) principles for a personalized application to inform, engage, and empower patients. We describe the evolutional details of four major versions, which represent milestones of our PFT, highlighting how specific objectives were achieved and the barriers encountered. Additionally, patient representatives were involved in the evaluation of prototypes, and …

18 Kda Translocator Protein (Tspo) Is Upregulated In Rat Brain After Peripheral Nerve Injury And Downregulated By Diroximel Fumarate, Rafael A Cazuza, Sever M Zagrai, Anamaria R Grieco, Thomas D Avery, Andrew D Abell, Hsiao-Ying Wey, Marco L Loggia, Peter M Grace

Faculty, Staff and Student Publications

Neuroimmune signaling is a key process underlying neuropathic pain. Clinical studies have demonstrated that 18 kDa translocator protein (TSPO), a putative marker of neuroinflammation, is upregulated in discrete brain regions of patients with chronic pain. However, no preclinical studies have investigated TSPO dynamics in the brain in the context of neuropathic pain and in response to analgesic treatments. We used positron emission tomography-computed tomography (PET-CT) and [18F]-PBR06 radioligand to measure TSPO levels in the brain across time after chronic constriction injury (CCI) of the sciatic nerve in both male and female rats. Up to 10 weeks post-CCI, TSPO expression was …

High-Grade B-Cell Lymphoma Not Otherwise Specified, With Diffuse Large B-Cell Lymphoma Gene Expression Signatures: Genomic Analysis And Potential Therapeutics, Waseem Lone, Alyssa Bouska, Tyler A Herek, Catalina Amador, Joo Song, Alexander M Xu, Dylan Jochum, Issa Ismail Issa, Dennis D Weisenburger, Xuan Zhang, Sharath Kumar Bhagavathi, Tayla B Heavican-Foral, Sunandini Sharma, Ab Rauf Shah, Abdul Rouf Mir, Aisha Ahmad Alkhinji, Dalia El-Gamal, Bhavana J Dave, Keenan Hartert, Jiayu Yu, Mallick Saumyaranjan, Timothy C Greiner, Julie Vose, Timothy W Mckeithan, Kai Fu, Michael Green, Chengfeng Bi, Akil Merchant, Wing C Chan, Javeed Iqbal

Faculty, Staff and Student Publications

High-grade B-cell lymphoma not otherwise specified (HGBCL, NOS) has overlapping morphological and genetic features with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL), leading to uncertainty in its diagnosis and clinical management. Using functional genomic approaches, we previously characterized HGBCL and NOS, that demonstrate gene expression profiling (GEP), and genetic signatures similar to BL. Herein, we characterize distinct HGBCL, NOS, cohort (n = 55) in adults (n = 45) and in children (n = 10), and compared the GEP, genomic DNA copy number (CN), and mutational spectrum with de novo DLBCL (n = 85) and BL (n = 52). …

Plasma Dna Methylation-Based Biomarkers For Mpnst Detection In Patients With Neurofibromatosis Type 1, Katarzyna Tomczak, Manishkumar S Patel, Angela D Bhalla, Christine B Peterson, Sharon M Landers, S Carson Callahan, Di Zhang, Justin Wong, Jace P Landry, Alexander J Lazar, J Andrew Livingston, B Ashleigh Guadagnolo, Heather G Lyu, Heather Lillemoe, Christina L Roland, Emily Z Keung, Christopher P Scally, Kelly K Hunt, Ian E Mccutcheon, John M Slopis, Jian Gu, Paul Scheet, Liang Wang, Kunal Rai, Keila E Torres

Faculty, Staff and Student Publications

Malignant peripheral nerve sheath tumor (MPNST) development is characterized by an altered DNA methylation landscape, which presents a promising area for developing MPNST-specific biomarkers for screening patients with NF1. Genome-wide DNA methylation profiling of a cohort of 13 patients with MPNST (29 samples of tumor and adjacent neurofibroma tissues) and of NF1-MPNST cell lines was performed to identify and validate candidate MPNST-specific CpG sites (CpGs). A logistic regression prediction model was constructed to select MPNST-specific CpGs distinct from adjacent neurofibromas and normal tissues. To test if hypermethylation at selected CpGs can also be detected in plasma from patients with MPNST, …

Approach To Determining Etiology Of Hypophosphatemia In A Patient With Coexisting Phosphaturic Mesenchymal Tumor And Fibrous Dysplasia, Madhuri D Patil, Sintawat Wangsiricharoen, Alexander J Lazar, Bryan Moon, John E Madewell, Michael T Collins, Theresa A Guise

Faculty, Staff and Student Publications

Dysregulated FGF23 production is a demonstrated cause of hypophosphatemia and osteomalacia. Diseases associated with these conditions include phosphaturic mesenchymal tumor (PMT) causing tumor induced osteomalacia, various forms of rickets, and fibrous dysplasia (FD). Coexistence of 2 conditions that can increase FGF23 concentrations is rare. We report a case of a 79-yr-old man who presented with rib and right flank pain. Imaging revealed bone lesions in the right iliac wing, left supra-acetabular area, and L4 vertebral body. Biopsies showed a right iliac PMT and left supra-acetabular FD. Cryoablation of both lesions resolved the phosphaturia with normalization of phosphorus level. Coexistence of …