Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 72331 - 72360 of 75740

Full-Text Articles in Entire DC Network

Bioaccumulation Of Legacy And Novel Pfas In The Environment, Hesham Taher, Rainer Lohmann Jan 2025

Bioaccumulation Of Legacy And Novel Pfas In The Environment, Hesham Taher, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

The bioaccumulation of per- and polyfluoroalkyl substances (PFAS), both legacy and novel, in the environment presents significant ecological and health risks. PFAS are a diverse group of synthetic chemicals known for their persistence and bioaccumulation, which can cause widespread environmental contamination and health risks. Strong carbon-fluorine bonds give these compounds unparalleled stability, preventing them from degrading and enabling them to endure in a range of environmental matrices, including water, soil, and biota. Legacy PFAS, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), have been extensively studied and regulated, resulting in lower concentrations in some environmental media. However, novel PFAS, …


Rebuttal To “Correspondence On ‘Scientists’ Statement On The Chemical Definition Of Pfass”, Gabriel Sigmund, Marta Venier, Marlene Ågerstrand, Ian T. Cousins, Jamie Dewitt, Miriam L. Diamond, Jennifer Field, Alex T. Ford, Shira Joudan, Stefan Van Leeuwen, Rainer Lohmann, Carla Ng, Martin Scheringer, Anna Soehl, Noriyuki Suzuki, Xenia Trier, Sara Valsecchi, Penny Vlahos, Cora J. Young, Zhanyun Wang Jan 2025

Rebuttal To “Correspondence On ‘Scientists’ Statement On The Chemical Definition Of Pfass”, Gabriel Sigmund, Marta Venier, Marlene Ågerstrand, Ian T. Cousins, Jamie Dewitt, Miriam L. Diamond, Jennifer Field, Alex T. Ford, Shira Joudan, Stefan Van Leeuwen, Rainer Lohmann, Carla Ng, Martin Scheringer, Anna Soehl, Noriyuki Suzuki, Xenia Trier, Sara Valsecchi, Penny Vlahos, Cora J. Young, Zhanyun Wang

Graduate School of Oceanography Faculty Publications

No abstract provided.


Corporate ‘Capture Strategies’ Impacting Human And Ecosystem Health, Alex T. Ford, Marlene Ågerstrand, Michael G. Bertram, Miriam L. Diamond, Rainer Lohmann, Andreas Schäffer, Martin Scheringer, Gabriel Sigmund, Anna Soehl, Maria Clara V.M. Starling, Noriyuki Suzuki, Marta Venier, Penny Vlahos Jan 2025

Corporate ‘Capture Strategies’ Impacting Human And Ecosystem Health, Alex T. Ford, Marlene Ågerstrand, Michael G. Bertram, Miriam L. Diamond, Rainer Lohmann, Andreas Schäffer, Martin Scheringer, Gabriel Sigmund, Anna Soehl, Maria Clara V.M. Starling, Noriyuki Suzuki, Marta Venier, Penny Vlahos

Graduate School of Oceanography Faculty Publications

The concept of regulatory capture has been extensively studied in academic literature, primarily within the social sciences. This phenomenon has been increasingly discussed in the environmental sciences as the impacts of regulatory capture on human and ecosystem health have become increasingly apparent. Regulatory capture is just one tactic employed by vested interests in the strategy of delaying, weakening, or abolishing policies designed to protect the public interest. Here, we define capture strategies as ‘the act of influencing individuals, organizations, or governments to prioritize corporate interests over those of human and ecosystem health’. Similar to the evolution of terms like whitewashing …


State Of The University Annual Report - 2024-2025, Office Of The President, East Tennessee State University, University Marketing And Communication, East Tennessee State University Jan 2025

State Of The University Annual Report - 2024-2025, Office Of The President, East Tennessee State University, University Marketing And Communication, East Tennessee State University

Office of the President State of the University Annual Report

No abstract provided.


Editors’ Introduction: 25th Anniversary Issue Of The Jiws, Diana J. Fox, Kimberly Chabot Davis, Priyanka Tripathi, Catherine Ndinda Jan 2025

Editors’ Introduction: 25th Anniversary Issue Of The Jiws, Diana J. Fox, Kimberly Chabot Davis, Priyanka Tripathi, Catherine Ndinda

Journal of International Women's Studies

No abstract provided.


Miss Usa Meets Feminism: A Qualitative Study Exploring Contestants’ Thoughts On Feminist Ideals, Julia Van Steenberghe, Sandra Caron Jan 2025

Miss Usa Meets Feminism: A Qualitative Study Exploring Contestants’ Thoughts On Feminist Ideals, Julia Van Steenberghe, Sandra Caron

Journal of International Women's Studies

This qualitative study explores pageant contestants’ views on feminism. A total of twelve state titleholders, aged 22-29, from the 2020 Miss USA Competition were interviewed about their motivations for participating, their own views on feminism, and their opinions about whether beauty pageants align with feminist ideals. The initial analysis of the interview transcripts revealed sixteen coding categories. A secondary analysis of these coding categories identified three overarching themes: “Pageants are Empowering,” “Swimsuit is Complicated,” and “Pageantry Has Evolved.” This study revealed that participants had many reasons for entering pageants, the least common of which related to beauty. Most …


Unveiling The Vulnerability Of Return Migration: A Feminist Embeddedness Perspective On Bangladeshi Women Workers, Faraha Nawaz, Tania Afrin Tonny Jan 2025

Unveiling The Vulnerability Of Return Migration: A Feminist Embeddedness Perspective On Bangladeshi Women Workers, Faraha Nawaz, Tania Afrin Tonny

Journal of International Women's Studies

This study explores the vulnerability of migrant workers returning to Bangladesh through the lens of van Houte and Davids’ (2008) embeddedness framework. Centering women’s narratives offers a feminist method of embeddedness, focusing on the economic, social, and psychosocial dimensions of returning migrants’ experiences. This paper addresses the vulnerabilities experienced by women upon their return, particularly those returning from the Middle East. Drawing on qualitative data from in-depth interviews with 30 Bangladeshi women domestic workers, this study identifies two primary causes for their return from the Middle East to Bangladesh: coercion by family members and coercion by employers. The findings indicate …


Migration And Work: An Intersectional Perspective On Women Workers In Brick Kilns In The Sivasagar District Of Assam, India, Kashmiri Saikia, Sikha Das Jan 2025

Migration And Work: An Intersectional Perspective On Women Workers In Brick Kilns In The Sivasagar District Of Assam, India, Kashmiri Saikia, Sikha Das

Journal of International Women's Studies

This paper is based on fieldwork regarding brick kiln workers in the Sivasagar district of Assam, located in Northeast India. Apart from family migration, women migrate alone to these brick kilns in search of work opportunities. Despite progress, evidence suggests that many women who work in brick kilns are not afforded workplace rights and are underrepresented, unregistered, and paid lesser wages compared to men workers. Many kilns are unregulated and remain outside the purview of workplace laws. Through interviews and conversations with women workers, this paper aims to understand and analyse the dynamics of gender, migration, and work in the …


Homophobic And Transphobic Bullying: Impacts On The Mental And Physical Health Of Queer Black Adolescents In Kacen Callender’S Young Adult Fiction, Uthra Devi R.K., C. Jothi, S. Rema Devi Jan 2025

Homophobic And Transphobic Bullying: Impacts On The Mental And Physical Health Of Queer Black Adolescents In Kacen Callender’S Young Adult Fiction, Uthra Devi R.K., C. Jothi, S. Rema Devi

Journal of International Women's Studies

This paper examines how homophobic bullying profoundly impacts the mental and physical health of Black queer children, with a particular focus on the rising suicide rate within this marginalized community. Analysing the representation of homophobic and transphobic bullying in Kacen Callender’s young adult fiction, this study explores the devastating impact of both verbal and nonverbal forms of abuse, including rejection, intimidation, and social isolation. These negative experiences contribute to long-term emotional distress, leading to an increased vulnerability to anxiety, depression, and suicidal ideation. Meyer’s minority stress theory is used to examine how systematic ignorance and rejection of queerness render Black …


A New Melian Dialogue: Feminist Thinkers On Security Problems Of The 21st Century, Heather Rellihan, Michael Coffey Jan 2025

A New Melian Dialogue: Feminist Thinkers On Security Problems Of The 21st Century, Heather Rellihan, Michael Coffey

Journal of International Women's Studies

This essay critically engages with two important works on feminist foreign policy— Kristina Lunz’s The Future of Foreign Policy is Feminist and Cynthia Enloe’s Twelve Feminist Lessons of War—both of which offer useful insights for the evolving field of critical security studies. The authors of this essay have divergent backgrounds—a professor of women’s, gender, and sexuality studies and a defense scholar—which reflect a central tension in feminist foreign policy between feminist principles and the paradigms and exigencies of defense policy makers. Through a constructed conversation between its authors, this essay engages the arguments of Lunz and Enloe to ask …


Recasting Gender Roles: The New Woman And The New Man In Women-Centred Contemporary Malayalam Films, Roshan B. Karimpaniyil, Shashikantha Koudur Jan 2025

Recasting Gender Roles: The New Woman And The New Man In Women-Centred Contemporary Malayalam Films, Roshan B. Karimpaniyil, Shashikantha Koudur

Journal of International Women's Studies

This article examines the representation of gender roles in select women-centred contemporary Malayalam films. It attempts to expand on the idea of the “new Indian woman” and develop a concept of the “new Indian man.” The new Indian woman is a byproduct of the cultural metamorphosis caused by liberalisation, while the new Indian man could be understood as the product of modern culture’s attempt to undermine traditional masculinity. By analysing the movies Biriyaani (2020), The Great Indian Kitchen (2021), Aanum Pennum (2021), and Sara’s (2021), as well as the short films Memories of a Machine (2016), Freedom @ Midnight (2021), …


Al-Rawabi School For Girls: The Arab Mean Girls?, Leen Masoud Jan 2025

Al-Rawabi School For Girls: The Arab Mean Girls?, Leen Masoud

Journal of International Women's Studies

Released in 2021 on Netflix and directed by Jordanian actress and director Tima Shomali, the television series Al-Rawabi School for Girls garnered international attention for its daring depiction of Jordanian girlhood and discussions of hard-hitting topics such as bullying, domestic abuse, sexual harassment, and honor killings. Despite its Jordanian context, the series engaged heavily with Hollywood tropes regarding girlhood, specifically the “mean girl” trope; the show referenced this trope so often that it began to be called “the Arab Mean Girls,” referring to the cult classic US film Mean Girls (2004). This essay critically examines the utilization of popular …


Advancing Gender-Inclusive Financial Systems: A G20 Policy Agenda For South Africa, Tinuade A. Ojo, M. E. Sotunsa, Diana J. Fox, Karen Carpenter, Leith L. Dunn Jan 2025

Advancing Gender-Inclusive Financial Systems: A G20 Policy Agenda For South Africa, Tinuade A. Ojo, M. E. Sotunsa, Diana J. Fox, Karen Carpenter, Leith L. Dunn

Journal of International Women's Studies

This policy brief calls for comprehensive reforms of South Africa’s financial systems to broaden women’s access to capital. Women’s economic empowerment is critical to inclusive and sustainable development in Africa. Despite ongoing global commitments to gender equality, systemic financial exclusion continues to marginalise women—particularly in South Africa—thereby impeding their full economic participation. Microfinance has emerged as a pivotal strategy for fostering financial inclusion among women, especially those in rural and economically disadvantaged urban areas. International models, such as the Grameen Bank, have illustrated that women from low-income backgrounds often exhibit higher loan repayment rates than their male counterparts. Institutions specifically …


Film Review: Breasts And Body Politics In B 32 Muthal 44 Vare, Aswathy A., Meenu B. Jan 2025

Film Review: Breasts And Body Politics In B 32 Muthal 44 Vare, Aswathy A., Meenu B.

Journal of International Women's Studies

No abstract provided.


Book Review: The Feminist Pacific: International Women’S Networks In Hawai’I, 1820–1940, Palak Arora, Manshi Yadav Jan 2025

Book Review: The Feminist Pacific: International Women’S Networks In Hawai’I, 1820–1940, Palak Arora, Manshi Yadav

Journal of International Women's Studies

No abstract provided.


Young Or Old, Smell The Roses In Your Practice, Michelle C. Dziurgot D.D.S. Jan 2025

Young Or Old, Smell The Roses In Your Practice, Michelle C. Dziurgot D.D.S.

The Journal of the Michigan Dental Association

This editorial reflects on the journey of becoming a dentist and the opportunity to inspire the next generation through compassionate care and education. It emphasizes the importance of fostering positive relationships with pediatric patients, using visits to showcase dentistry as a fulfilling career. By encouraging interest in the dental field among young patients and engaging with community programs, dental professionals can nurture future colleagues. The piece also acknowledges challenges, such as overcoming patient fears and misconceptions, and offers strategies for maintaining personal motivation and patient trust. Ultimately, it calls for a balance between professional dedication and personal satisfaction in dentistry.


Mda Foundation: Great Things Are Ahead For The Mda Foundation In 2025, Anne Berquist Jan 2025

Mda Foundation: Great Things Are Ahead For The Mda Foundation In 2025, Anne Berquist

The Journal of the Michigan Dental Association

The MDA Foundation expresses heartfelt gratitude to donors and volunteers who contributed to improving oral health care access and education in 2024. Efforts included funding free and reduced-cost clinics, awarding scholarships, and hosting the Mission of Mercy (MOM) free clinic in Flint. For 2025, plans include the Sparkling Smiles fundraising event during the MDA Annual Session in Detroit and laying the groundwork for next year’s MOM in Kalamazoo. The Foundation encourages applications for grants (deadline: May 1) and scholarships (applications open Aug. 1), continuing its commitment to supporting Michigan communities and dental students.


Find Your Brave Spot!, Jessica R. Bentoski D.D.S., M.S., F.A.A.P.D. Jan 2025

Find Your Brave Spot!, Jessica R. Bentoski D.D.S., M.S., F.A.A.P.D.

The Journal of the Michigan Dental Association

This introduction emphasizes the importance of overcoming fear, both in pediatric patients and within personal and professional growth. The author reflects on the rewarding experience of helping children manage dental anxiety and encourages peers to find their "brave spot" to embrace challenges and opportunities in dentistry. Highlighted articles in the issue focus on practical approaches for treating children with special needs and the importance of prenatal care for establishing a foundation for oral health. The message celebrates mentorship, leadership, and the joy of serving young patients.


General Dentists’ Education, Knowledge, Attitudes And Behavior Concerning The Effects Of Pregnant Patients’ Oral Health On Pregnancy Outcomes: A National Survey, Abad Mohammed O. Khuraybah B.D.S., M.S., James R. Boynton D.D.S., M.S., Robert F. Majewski D.D.S., M.S., Marita R. Inglehart Dr. Phil. Habil. Jan 2025

General Dentists’ Education, Knowledge, Attitudes And Behavior Concerning The Effects Of Pregnant Patients’ Oral Health On Pregnancy Outcomes: A National Survey, Abad Mohammed O. Khuraybah B.D.S., M.S., James R. Boynton D.D.S., M.S., Robert F. Majewski D.D.S., M.S., Marita R. Inglehart Dr. Phil. Habil.

The Journal of the Michigan Dental Association

Objectives: Since 1996, substantial evidence showed that pregnant patients’ oral health and pregnancy outcomes are related. The objectives were to assess general dentists’ education, knowledge, and behavior related to treating pregnant patients and how COVID-19 changed behavior related to these patients’ treatment.

Methods: 2,500 surveys were mailed to general dentists who were members of the American Dental Association; 96 letters were undeliverable and 253 surveys were completed (Response rate: 10.52%).

Results: 50.2% agreed/strongly agreed that they were well-educated in dental school about treating pregnant patients. Only 34% were satisfied with this education. The majority knew that periodontal disease was associated …


New Student Convocation, Krysten Walowski Jan 2025

New Student Convocation, Krysten Walowski

Remarks and Messages

No abstract provided.


University Of Minnesota Morris Catalog 2025-2027, University Of Minnesota-Morris Jan 2025

University Of Minnesota Morris Catalog 2025-2027, University Of Minnesota-Morris

UMM Catalog

This document serves as an official historical record for a specific period in time. The information found is subject to change without notice. Colleges and departments make changes to their degree requirements and course descriptions frequently. More information is available at catalogs.umn.edu.


Working With Physical And Virtual Manipulatives: A Systematic Review Of Affordance And Cognitive Engagement Manifested Through Implementation, Seokmin Kang, Chun-Hao Chang, Sungyeun Kim Jan 2025

Working With Physical And Virtual Manipulatives: A Systematic Review Of Affordance And Cognitive Engagement Manifested Through Implementation, Seokmin Kang, Chun-Hao Chang, Sungyeun Kim

Teaching and Learning Faculty Publications

Virtual tools are rapidly supplementing physical tools in classrooms. Although extensive research has compared the benefits of using virtual and physical manipulatives, few studies have systematically explored the learning benefits of using a physical and a virtual tool. As the major learning goal in science, technology, engineering, and mathematics (STEM) education is to help students better understand scientific and mathematical concepts and processes, this study reviewed empirical studies comparing learning performance between working with physical and virtual manipulatives published between 2000 and 2022 in Education and Psychology journals. The results revealed inconsistent patterns in learning comparison across studies even with …


On Minimizing Risk And Harm In The Use Of Psychedelics, Jules Evans, Marc Aixalà, Brian T Anderson, William Brennan, Rebecka Bremler, Joost J Breeksema, Lisa Burback, Abigail E Calder, Robin L Carhart-Harris, Katherine Cheung, Neşe Devenot, Ingmar Gorman, Jakub Greń, Peter S Hendricks, Brian Holoyda, Edward Jacobs, Joy Krecké, Daniel J Kruger, David Luke, Tomislav Majić, Amy L Mcguire, Nicky J Mehtani, David S Mathai, Kristin Nash, Tehseen Noorani, Roman Palitsky, Oliver C Robinson, Otto Simonsson, Elin Stahre, Michiel Van Elk, David B Yaden Jan 2025

On Minimizing Risk And Harm In The Use Of Psychedelics, Jules Evans, Marc Aixalà, Brian T Anderson, William Brennan, Rebecka Bremler, Joost J Breeksema, Lisa Burback, Abigail E Calder, Robin L Carhart-Harris, Katherine Cheung, Neşe Devenot, Ingmar Gorman, Jakub Greń, Peter S Hendricks, Brian Holoyda, Edward Jacobs, Joy Krecké, Daniel J Kruger, David Luke, Tomislav Majić, Amy L Mcguire, Nicky J Mehtani, David S Mathai, Kristin Nash, Tehseen Noorani, Roman Palitsky, Oliver C Robinson, Otto Simonsson, Elin Stahre, Michiel Van Elk, David B Yaden

Center for Medical Ethics and Health Policy Staff Publications

Objective: This article outlines recommendations from 30 psychedelic researchers on how to create a better psychedelic safety net.

Methods: A survey of 30 psychedelic researchers asked them to identify key critical research gaps around psychedelic harm and safety.

Results: The critical research gaps identified by the authors included defining the main types of psychedelic harm, the predictors of those harms, and the most effective way to treat those harms. They also call for better support for those experiencing post-psychedelic difficulties, including better online information, peer support groups, affordable therapy, and psychiatric consultation and medication. Finally, the authors call for better …


The Infected Diabetic Foot: Risk Factors For Re-Infection After Treatment For Diabetic Foot Osteomyelitis, Lawrence A Lavery, Mario C Reyes, Bijan Najafi, Tyler L Coye, Matthew Sideman, Michael C Siah, Arthur N Tarricone Jan 2025

The Infected Diabetic Foot: Risk Factors For Re-Infection After Treatment For Diabetic Foot Osteomyelitis, Lawrence A Lavery, Mario C Reyes, Bijan Najafi, Tyler L Coye, Matthew Sideman, Michael C Siah, Arthur N Tarricone

Center on Aging Staff Publications

Our objective was to evaluate risk factors for re-infection in patients after treatment for diabetic foot osteomyelitis (OM). We used pooled patient level data from two RTCs that evaluated patients with diabetic foot infections. We evaluated 171 patients with OM. OM was confirmed with bone culture or histopathology. Data from the 12-month follow-up were used to determine clinical outcomes. Re-infection occurred in 47 (27.5%) patients. Risk factors for re-infection were Toe Brachial Index < 0.40 (25.7% vs. 9.8%, p = 0.02), skin perfusion pressure < 40 mmHg (6.3% vs. 5.9%, p = 0.04), wound healing (55.3% vs. 75.0%, p = 0.01), time to heal (156.0, 69.5-365 vs. 91.5, 38.8-365, p = 0.001), and history of MI (14.9% vs. 3.2%, p = 0.005). During 12-month follow-up, patients with re-infections were 198.8 times more likely to require a foot related hospitalisation (81.8% vs. 0.0%, p = 0.001), 10.4 times more likely have an all-cause hospitalisation (70.2% vs. 18.5%, p = 0.001) and 9.4 times more likely to need an amputation (36.2% vs. 5.6%, p = 0.001). Patients with re-infection had a significantly longer median length of hospitalisation (20.0, 13.5-34.5 vs. 14.0, 10.0-22.0, p = 0.003) and median length of antibiotic duration (55.0, 35.0-87.0 vs. 46.0, 22.8-68.0, p = 0.03). Patients with re-infection are less likely to heal and have more foot-related hospitalizations and amputations.


The Impact Of Insurance On Adolescent Transition To Adult Care, Diane V Murrell, Cassandra J Enzler, Lauren Bretz, Beth H Garland, Albert C Hergenroeder, Christine Markham, Constance M Wiemann Jan 2025

The Impact Of Insurance On Adolescent Transition To Adult Care, Diane V Murrell, Cassandra J Enzler, Lauren Bretz, Beth H Garland, Albert C Hergenroeder, Christine Markham, Constance M Wiemann

Faculty, Staff and Student Publications

Background: This study sought to examine how adolescents and young adults with special health care needs (AYA) prepare for managing medical insurance (private and public) as an adult and the role of insurance in locating an adult provider and engaging in care.

Methods: Twenty-eight AYA aged 18-24 years with renal, inflammatory bowel, or rheumatologic diseases completed individual semi-structured interviews designed to evaluate the impact of insurance (private vs. public) on their health care transition experiences. An interdisciplinary team of coders analyzed transcripts using The Framework Method.

Results: Three themes emerged: continuum of accepting health insurance responsibility; the impact of insurance …


Single-Cell Multiome Characterizing Intercellular Communication And Intracellular Regulation Of Epithelium And Mesenchymal During Secondary Palate Development In Mice, Usama Hussein, Yulin Dai, Andi Liu, Toshiyuki Itai, Fangfang Yan, Lukas M Simon, Zhongming Zhao Jan 2025

Single-Cell Multiome Characterizing Intercellular Communication And Intracellular Regulation Of Epithelium And Mesenchymal During Secondary Palate Development In Mice, Usama Hussein, Yulin Dai, Andi Liu, Toshiyuki Itai, Fangfang Yan, Lukas M Simon, Zhongming Zhao

Faculty, Staff and Student Publications

Cell-cell communication between adjacent tissues is fundamental to orchestrating organ morphogenesis. During secondary palate development, interactions between epithelial and mesenchymal cells regulate epithelial-mesenchymal signaling, thereby controlling cell proliferation, differentiation, and tissue patterning. However, the precise molecular mechanisms underlying these interactions remain largely unexplored. In this study, we employed single-cell multiome sequencing to simultaneously profile chromatin accessibility and gene expression in 35,150 individual cells isolated from the developing mouse secondary palate at embryonic days E12.5, E13.5, E14.0, and E14.5. Our analysis revealed that intercellular signaling plays a pivotal role in directing secondary palate morphogenesis, with WNT, BMP, and PDGF pathways emerging …


Survey And Improvement Strategies For Gene Prioritization With Large Language Models, Matthew B Neeley, Guantong Qi, Guanchu Wang, Ruixiang Tang, Dongxue Mao, Chaozhong Liu, Sasidhar Pasupuleti, Bo Yuan, Fan Xia, Pengfei Liu, Zhandong Liu, Xia Hu Jan 2025

Survey And Improvement Strategies For Gene Prioritization With Large Language Models, Matthew B Neeley, Guantong Qi, Guanchu Wang, Ruixiang Tang, Dongxue Mao, Chaozhong Liu, Sasidhar Pasupuleti, Bo Yuan, Fan Xia, Pengfei Liu, Zhandong Liu, Xia Hu

Duncan NRI Faculty and Staff Publications

Motivation: Rare diseases remain difficult to diagnose due to limited patient data and genetic diversity, with many cases remaining undiagnosed despite advances in variant prioritization tools. While large language models have shown promise in medical applications, their optimal application for trustworthy and accurate gene prioritization downstream of modern prioritization tools has not been systematically evaluated.

Results: We benchmarked various language models for gene prioritization using multi-agent and Human Phenotype Ontology classification approaches to categorize patient cases by phenotype-based solvability levels. To address language model limitations in ranking large gene sets, we implemented a divide-and-conquer strategy with mini-batching and token limiting …


Talking About Suffering In The Intensive Care Unit, Brent M Kious, Judith B Vick, Peter A Ubel, Olivia Sutton, Jennifer Blumenthal-Barby, Christopher E Cox, Deepshikha Ashana Jan 2025

Talking About Suffering In The Intensive Care Unit, Brent M Kious, Judith B Vick, Peter A Ubel, Olivia Sutton, Jennifer Blumenthal-Barby, Christopher E Cox, Deepshikha Ashana

Center for Medical Ethics and Health Policy Staff Publications

Background: Some have hypothesized that talk about suffering can be used by clinicians to motivate difficult decisions, especially to argue for reducing treatment at the end of life. We examined how talk about suffering is related to decision-making for critically ill patients, by evaluating transcripts of conversations between clinicians and patients' families.

Methods: We conducted a secondary qualitative content analysis of audio-recorded family meetings from a multicenter trial conducted in the adult intensive care units of five hospitals from 2012-2017 to look at how the term "suffering" and its variants were used. A coding guide was developed by consensus-oriented discussion …


A Hybrid Cloud Data Lake Architecture Supporting The Integration Of Clinical And Genomics Data, Apollo Mcowiti, Heidi Dowst, Fei Zheng, Susan Hilsenbeck, Christopher Amos Jan 2025

A Hybrid Cloud Data Lake Architecture Supporting The Integration Of Clinical And Genomics Data, Apollo Mcowiti, Heidi Dowst, Fei Zheng, Susan Hilsenbeck, Christopher Amos

Center for Medical Ethics and Health Policy Staff Publications

Objective: Cancer centers must quickly integrate clinical genomics data from different vendors for oncology operations and research. Clinical data warehouse architectures are costly to construct and brittle, and they are not readily amenable to the rapid changes in oncology research. We introduce a cost-effective hybrid cloud Data Lake architecture for storing clinical genomic data from different vendors, aiding both clinical and research workflows.

Methods: We created a Data Lake architecture based on the zone architecture, with four layers: ingestion, storage, transformation, and interaction. The layers are implemented with a hybrid cloud architecture. Rich metadata created from patient and genomic data …


Moving Beyond Simplistic Research Design In Health Professions Education: What A One-Group Pretest-Posttest Design Will Not Prove, S Beth Bierer, Gary Beck Dallaghan, Nicole J Borges, Sam Brondfield, Cha Chi Fung, Kathryn N Huggett, Cayla R Teal, Satid Thammasitboon, Colleen Y Colbert Jan 2025

Moving Beyond Simplistic Research Design In Health Professions Education: What A One-Group Pretest-Posttest Design Will Not Prove, S Beth Bierer, Gary Beck Dallaghan, Nicole J Borges, Sam Brondfield, Cha Chi Fung, Kathryn N Huggett, Cayla R Teal, Satid Thammasitboon, Colleen Y Colbert

Center for Medical Ethics and Health Policy Staff Publications

Introduction: Educational research presents unique study design challenges. Novice researchers in health professions education (HPE) frequently misuse the one-group pretest-posttest design, highlighting the need for improved training in research design. This workshop aimed to enhance understanding of research design among novice HPE researchers, specifically addressing the inherent limitations of the one-group pretest-posttest design and offering alternative approaches.

Methods: Experienced HPE researchers developed this workshop to address common misunderstandings of research design. Leaders from the AAMC Medical Education, Scholarship, Research, and Evaluation section facilitated 60-75-minute workshops conducted at the four 2024 regional meetings hosted by the AAMC Group on Educational Affairs …