Digital Commons Network^™

Long-Term Outcomes And Treatment Patterns In Waldenström Macroglobulinemia Patients Who Discontinue Bruton Tyrosine Kinase Inhibitor (Btki) Therapy, Karan L Chohan, Lorenzo Gensini, Sherif Seif, Xiaowen Sun, Lei Feng, Melody R Becnel, Mahmoud M Gaballa, Hans C Lee, Oren Pasvolsky, Krina K Patel, J Christine Ye, Donna M Weber, Robert Z Orlowski, Sheeba K Thomas

Faculty, Staff and Student Publications

No abstract provided.

Cdk2 Inhibition Enhances Cdk4/6 Inhibitor Antitumor Activity In Comprehensive Breast Cancer Pdx Model Screen, Nealia C House, Maxine M Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, Linjie Luo, Ningping Feng, Christopher A Bristow, Timothy A Yap, Khandan Keyomarsi, Joseph R Marszalek, Scott Ribich, Mikael L Rinne, Lakshmi B Muthuswamy, Kerrie L Faia

Faculty, Staff and Student Publications

Aberrant cyclin-dependent kinase 2 (CDK2) activity is implicated as a resistance mechanism to CDK4/6 inhibitors (CDK4/6i) in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Using preclinical patient-derived xenograft models, the CDK2i + CDK4/6i combination was active broadly across CDK4/6i-resistant and -naïve HR+ and triple-negative breast cancer models. A novel, weighted mRNA expression signature involving CCND1, CCNE1, RB1, and CDKN2A (p16) predicted response to combined inhibition of CDK2 and CDK4/6. Addition of endocrine therapy significantly enhanced antitumor activity in HR+ models, providing preclinical proof-of-concept for the broad antitumor activity of the triple combination. Early clinical data demonstrated …

The Nature And Distribution Of Road Sediment Contaminants In The Greater Las Vegas, Nevada Area, K. J. Gokey, M. Gillis, Kenneth L. Brown, N. Renkes, C. L. Mcleod, M.P.S. Krekeler

Geology and Environmental Geoscience Faculty Publications

Road sediment is an underutilized medium in the investigation of environmental pollution, yet it serves as both a source and sink for a wide array of pollutants. In urban areas especially, contaminants present within road sediment have the potential to pose human health risks depending on the abundance, chemical, and physical nature of these contaminants as well as the duration (i.e. acute or chronic) of exposure. Las Vegas, Nevada is currently one of the fastest growing urban areas in the United States and is therefore a prime location for the investigation of potential environmental contaminants and pollutants in road sediment. …

Unsaturated Fatty Acid Oil-Based Microdroplets: A Promising Novel Class Of Microdroplets, Ramiz S. Alejilat

Seton Hall University Dissertations and Theses (ETDs)

Droplet-based microfluidics has rapidly advanced numerous fields, including chemistry, biology, materials science, medicine, food science, and cosmetics. In these systems, fluorocarbon oil combined with fluorinated surfactants is the preferred medium for fluid encapsulation, offering exceptional stability and biocompatibility essential for sensitive biological and chemical processes. However, growing concerns about the environmental and biological risks associated with fluorinated chemicals have prompted a search for alternatives.

This study is the first to explore the use of unsaturated fatty acids derived from emu oil for microdroplet formation. We characterized droplet formation based on flow rates and the presence non-fluorinated surfactant at a certain …

Fall 2025 Student Scholar Symposium Abstract Volume, Chapman University Center For Undergraduate Excellence

Student Scholar Symposium Abstracts and Posters

No abstract provided.

Tracking Wellness: A Semester Long Analysis Of Daily Habits And Lifestyle Choices, Elsa Garcia-Nguyen

Student Scholar Symposium Abstracts and Posters

Throughout the course of a semester, personal data was collected and analyzed to better understand how daily habits influence physiological and behavioral patterns. Data was recorded each day across multiple variables including caffeine intake, TikTok screen time, amount of sleep, amount of steps, distance traveled, allergy medicine adherence, cooking dinner or eating out, energy level, mediation practice, and amount of time studying. The purpose of this project was to explore how these daily lifestyle choices may relate to overall physical and mental well-being. By consistently tracking these behaviors, a dataset was created that captures patterns in daily habits and routines …

Computational Molecular Docking Of Fluorinated Morphine Derivatives For Improved Pain Management, Mirabella Romano, Emily Chen

Student Scholar Symposium Abstracts and Posters

The opioid epidemic impacts 60 million people worldwide every year. Morphine, a commonly prescribed opioid, binds to the μ-opioid receptor (MOR) in the body via protonation of its tertiary amino group and the MOR. An unfortunate side effect of this binding process is its non-selectivity in both peripheral and central tissues. While activation within inflamed peripheral tissues results in pain relief, activation within central tissues results in the unwanted and addictive side effects of opioids. Because there is a discrepancy in pH between healthy (central) and inflamed (peripheral) tissue, selective binding within the inflamed tissues could provide pain relief without …

Understanding Daily Habits Affect On Mood: A Semester-Long Wellness Analysis, Alexis Caitlin Sweeney

Student Scholar Symposium Abstracts and Posters

This research aims to track and assess lifestyle and personal health behaviors over a semester in order to gain a better understanding of how daily routines impact overall well-being. Ten variables are being monitored, including weight, caffeine intake, sleep duration, napping, exercise frequency, homework hours, Instagram screen time, vitamin use, practicing miles, and mood evaluations on a 5-point scale. I intend to identify trends and relationships between these factors through consistent data collection throughout the semester, such as the effects of sleep and caffeine on mood, motivation, and productivity.

As a student-athlete and health science major, this initiative gives me …

Loneliness And Support For Political Violence Within The United States, Kellen Downey

Student Scholar Symposium Abstracts and Posters

Although loneliness is a growing public health issue in the United States, its political effects remain understudied. This paper seeks to understand the relationship between loneliness and the support of political violence by utilizing the Chapman Survey of American Fears (CSAF Wave 11). This survey, which is a component of the 2025 Chapman Survey of American Fears, includes the three-item UCLA Loneliness Scale, as well as two separate items specifically measuring political violence. Using a national survey (N=1,015), I address the following questions: (1) Are lonely individuals more likely to support violence on political grounds? (2) Does strongly identifying with …

2026 Favorite Foods Festival Participation Packet For Rockingham And Strafford Counties, Caitlin Wollack

UNH Cooperative Extension

No abstract provided.

2025-12-03 Seattle U College Of Nursing Celebrates Ninety Years Of Care And Collaboration, Leila Bunker, Alice Makarenko

The Spectator Online

No abstract provided.

2025-12-03 Letter To The Editor: Student Letter To Su Administration Regarding Interim President, Seattle University

The Spectator Online

No abstract provided.

2025-12-03 Newly Defined Professional’ Degrees Threaten Future Graduate School Loans, Kean Mathis

The Spectator Online

No abstract provided.

Anti-Imperialism & Neo-Colonialism, The Philosophical Discussion Group

The Philosopher's Stone

• Anti-Imperialism & Neo-Colonialism

Teaching Dental Public Health Using A Socially Accountable Approach, Anastasios Plessas, Martha Paisi, Nilufar Ahmed, Zoe Brookes, Robert Witton

Peninsula Dental School

Traditional approaches to dental public health education across Europe remain dominated by lecture-based learning which often fail to cultivate critical reflection on inequities, privilege, and the broader social determinants of oral health. Social accountability has been recognized as core competency for dental graduates, requiring dental professionals to align professional practice with the health needs of communities. Community-engaged education is a promising pedagogical model that situates learning within real-world contexts, fosters empathy, cultural competence, and advocacy skills, and strengthens professional identity formation. This paper discusses the Peninsula Dental School’s innovative model, which integrates community engagement, reflective practice, and interprofessional education within …

Alzheimer's Medications And Polypharmacy Management In Advanced Dementia And Hospice Care, Rana Senlik, Robert Martin

Advocate GME

No abstract provided.

The Perspectives And Experiences Of Prospective Parents Declining Diagnostic Prenatal Genome Sequencing In Continuing Pregnancies With Fetal Structural Anomalies, Lisa S Weingarten, Allison Rosenbaum, Jessica De Voest, Stephanie Galloway, Jessica L Giordano, Samantha Stover, Lauren E Westerfield, Grant Bonesteele, Kelly L Gilmore, Leandra Tolusso, Beatrix Wong, A Theresa Wittman, Daniel T Swarr, Nancy Leslie, Anthony Johnson, Ignatia B Van Den Veyver, Neeta L Vora, Rebecca G Clifton, Aaron B Caughey, Ronald J Wapner, Wendy K Chung

Duncan NRI Faculty and Staff Publications

Objective: This study evaluates an understudied perspective: the experiences of prospective parents who decline prenatal genome sequencing (pGS) for continuing pregnancies with fetal structural anomalies.

Method: We recruited a total cohort of 300 parents of 150 pregnancies who declined pGS, including 33 individuals who underwent an invasive procedure. These parents were invited to participate in a semi-structured interview between 1 and 15 months post-partum. We used Thematic Analysis to code and analyze interviews.

Results: We interviewed 22 parents of 16 pregnancies. Reasons for declining testing included risks of invasive procedures (n = 19, 86%), lack of prenatally actionable findings (n …

Medicaid Funding And Health-Related Social Needs: A Policy Analysis, Passion Ilea

Dissertations and Theses

The U.S. has disproportionately high health care spending compared to other high-income nations and comparatively poor health outcomes. The Centers for Medicare and Medicaid Services (CMS) have recently increased emphasis on addressing Medicaid member social needs. CMS believes addressing health-related social needs (HRSN) may reduce costs and improve health outcomes for Medicaid members. CMS has begun to test theories regarding the impact of member HRSN on health care by designing federal mechanisms to address HRSN, such as in lieu of services and settings-funded services, and by encouraging state Medicaid programs to develop their own approaches, such as Flexible Services. Information …

A Distinct Pp2a Subunit Regulates Local Protein Phosphorylation At The Axon Initial Segment, Andrew P Anderson, Sanghyun Kim, Allison J Melton, Xiaoyun Ding, Wei Zhang, Alexander B Saltzman, Anna Malovannaya, Matthew N Rasband, Yudong Gao

Faculty, Staff and Students Publications

Protein phosphorylation plays a crucial role in regulating the cytoskeletal and membrane proteins at the axon initial segment (AIS). However, our knowledge of AIS-specific kinases and phosphatases is very limited. Here, we report the identification of a protein phosphatase 2A (PP2A) B55 regulatory subunit enriched at the AIS in mice: Ppp2r2c. Our results demonstrate that PP2A-B55 subunits exhibit substantial heterogeneity in their subcellular localization and function. Notably, the Ppp2r2c subunit is selectively concentrated at the AIS, and this enrichment is driven by its unique structure. Utilizing a microelectrode array system (MEA), we show that Ppp2r2c modulates neuronal activity during in …

Unconventional Binding Of Calmodulin To Chk2 Kinase Inhibits Catalytic Activity, Christopher R Horne, Tingting Wang, Samuel N Young, Toby A Dite, Hunter G Nyvall, Sushant Suresh, Katherine A Davies, Abner Gonzalez Castro, Vineet Vaibhav, Lucy J Mather, Laura F Dagley, Matthew J Belousoff, Gerard Manning, Anthony R Means, John E Burke, Janni Petersen, John W Scott, James M Murphy

Faculty, Staff and Students Publications

Calmodulin (CaM) serves an essential role in eukaryotic cells as a Ca2+ sensor. Ca2+ binding leads to conformation changes in CaM that enable engagement of a repertoire of enzymes and the regulation of their catalytic activities. Classically, Ca2+-CaM binds to an inhibitory pseudosubstrate sequence C-terminal to the kinase domain in members of the Ca2+-CaM-dependent protein kinase (CAMK) family and relieves inhibition to promote catalytic activity. Here, we report an unexpected mechanism by which CaM can bind CHK2 kinase to inhibit its kinase activity. Using biochemical, biophysical and structural mass spectrometry, we identify a direct interaction of Ca2+-CaM with the CHK2 …

Restoration Of Sfrp3 Preserves The Neural Stem Cell Pool And Spatial Discrimination Ability In A Mouse Model Of Alzheimer's Disease, Chia-Hsuan Fu, Jin Park, Umberto Tosi, Francisco A Blanco, Manuel Silva-Pérez, Kavitha Muralidharan, Jason C You, Minjung Lee, Gabriel S Stephens, Xiaohong Zhang, Yi Zheng, Helen Scharfman, Kimberley F Tolias, Jeannie Chin

Faculty, Staff and Students Publications

Individuals with Alzheimer's disease (AD) have an increased incidence of seizures, which worsen cognitive decline. Using a transgenic mouse model of AD neuropathology that exhibits spontaneous seizures, we previously found that seizure activity stimulates and accelerates depletion of the hippocampal neural stem cell (NSC) pool, which was associated with deficits in neurogenesis-dependent spatial discrimination. However, the precise molecular mechanisms that drive seizure-induced activation and depletion of NSCs are unclear. Here, using mice of both sexes, we performed RNA-sequencing on the hippocampal dentate gyrus and identified differentially expressed regulators of neurogenesis in the Wnt signaling pathway that regulates many aspects of …

Investigating Dysfunctional Cognition Change As A Putative Mechanism Of Cbt For Youth Anxiety, Ocd And Ptsd: Protocol For An Individual Participant Data Meta-Analysis, Ivana Buric, Anke Klein, Ronald M Rapee, Brooke Levis, Philip C Kendall, Eric A Storch, Lynn Mobach

Faculty, Staff and Students Publications

Introduction: Anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are common in children and adolescents and can lead to significant impairment. Cognitive behavioural therapy (CBT) with exposure is the first-line treatment, yet approximately half of treated youth do not achieve full remission. Dysfunctional cognitions-negative automatic thoughts, maladaptive beliefs and distorted interpretations-are considered key targets of CBT, but evidence in youth is mixed and underpowered. This study will examine whether change in dysfunctional cognitions mediates treatment outcome in anxiety, OCD and PTSD symptoms and whether this association varies across individual characteristics.

Methods and analysis: An individual participant data meta-analysis …

Resolving The Mysteries Of Brain Clearance And Immune Surveillance, Jonathan Kipnis, Et Al.

2020-Current year OA Pubs

Recent advances are transforming our understanding of brain fluid dynamics, highlighting cerebrospinal fluid (CSF) flow as a key process in brain waste clearance. While debates persist regarding its anatomical pathways and regulatory mechanisms, certain core principles have become widely accepted. CSF influx occurs primarily along periarterial spaces, solute clearance follows multiple routes, and glymphatic and meningeal lymphatic systems are functionally connected. Brain clearance is influenced by vascular pulsation, neural activity, and sleep. Immune cells at brain-border niches both monitor solute efflux and modulate flow, linking brain clearance to neuroimmune interactions. A deeper understanding of brain clearance could unlock new therapeutic …

Operationalizing Passive Sensors Into Scalable, Reproducible, Neurobehavioral Digital Markers For Alzheimer's Disease: Lessons Learned Over 10 Years, Ganesh M Babulal, Matthew Blake, Chen Chen, Yiqi Zhu, Subrata Pal, David C Brown

2020-Current year OA Pubs

No abstract provided.

Artificial Intelligence In Higher Education: Opportunities And Challenges, Maytha Al-Ali, Adam Marks, Jasur Umirzokov, Noura Metawa

Iraqi Journal for Computer Science and Mathematics

While AI is often presented as a panacea for the challenges facing higher education, there is limited empirical evidence supporting its effectiveness in improving student learning and institutional performance. This gap between expectation and reality emphasizes the need for rigorous research, realistic goal-setting, and careful planning to ensure that AI technologies deliver on their promises in higher education. This study contrasts the potential utilization of AI technologies in Higher Education from the literature, against actual utilization in universities. The study also investigates the key barriers of AI implementation in higher education. This study uses a mixed-research methods approach, including case …

Cost-Benefit Analysis Program Percontohan Pengendalian Rabies Berbasis One Health Di Wilayah Sanur, Denpasar Selatan, Marheni Ni Wayan, Sutarsa I Nyoman, Made Subrata

Jurnal Ekonomi Kesehatan Indonesia

Rabies continues to pose a significant public health challenge in Bali Province, Indonesia. The Dharma Program, a rabies control initiative based on the One Health approach, has been implemented in multiple areas of the province. Sustaining and expanding this program requires an economic evaluation that compares the cost burden of rabies under scenarios with and without program implementation. This study was conducted in two pilot villages: Sanur Kaja (SKJ) and Sanur Kauh (SKH). Cost data were obtained from activity reports, published literature, and structured interviews with program managers. Benefit values were estimated using scenario modeling, which included treatment costs, post-exposure …

Analisis Perbedaan Biaya Satuan Sectio Caesarea Tanpa Penyulit Dengan Tarif Ina-Cbgs Di Rumah Sakit Swasta Tipe D (X) Di Ternate Tahun 2022, Ummu Hani Mars, Prastuti Soewondo

Jurnal Ekonomi Kesehatan Indonesia

Cesarean section unit cost is an important component for hospital’s management to implement strategic efficiency steps in the future, especially for Rumah Sakit X which 90% of patients are Jaminan Kesehatan Nasional’s participant. Geographically, this hospital is one of hospitals which serve delivery and labor services in Ternate Island that can accommodate references from nearby islands. This resulting in high caesarean section rate, 55 % of all deliveries. The low JKN rate for caesarean section forced management to know the detailed cost component, so the efficiency strategies and the continuity of hospital services could be more increased. This research through …

Analisis Perbandingan Biaya Dan Penggunaan Obat Antara Pasien Bpjs Kesehatan Dan Non-Bpjs Kesehatan Periode Januari-Desember 2022 Di Klinik Pratama X Kota Bandung, Phebe Ariella Wilis, Tjokorde Istri Armina Padmasawitri, Syifa Fitrah Qanaah

Jurnal Ekonomi Kesehatan Indonesia

Primary healthcare facilities may have two sources of drug funding: capitation funds for drugs prescribed to patients under the Social Security Administering Agency (BPJS Kesehatan), and out-of-pocket payments from non-BPJS Kesehatan patients. Analyzing drug utilization patterns and financing is essential to ensure the efficient use of these funding sources. This study aims to analyze drug costs and utilization among BPJS Kesehatan patients compared to non-BPJS Kesehatan patients at Primary Clinic X in Bandung City from January to December 2022.This study used a retrospective cross-sectional design with data collected from electronic medical records and pharmacy transactions. Descriptive analysis was employed to …

Technology Use In Elementary Music Education: A Scoping Review, David T. Casali

Journal of the Association for Technology in Music Instruction

The purpose of this scoping review was to look at how music technology has been used in the elementary music classroom from 2020 to April 2025. Uses of technology were organized using the Substitution, Augmentation, Modification, and Redefinition (SAMR) model (Puentedura, 2006). Only articles that both described how technology was used and what the learning process looked like were included. A total of 26 articles met the criteria for inclusion. Multiple uses of technology across the four levels of the SAMR were represented from 14 different countries. An article from each of the four SAMR levels is described in depth …

Effects Of Ghost Energy Drink On Muscle Strength, Psychomotor Vigilance, And Mood., Jason M. Curtis, Jose J. Rojas, Flavia F. Pereira, Cassandra Evans, Elizabeth Espocito, Alyana Andal Andal, Gavin Poulshock, Hena Thakkar, Taila De Castro, Alexandra Jimenez, Antonio Cristanti, Antonella V. Schwarz, Juan Carlos Santana, Jose Antonio

Journal for Sports Neuroscience

Abstract

Background: This study aimed to evaluate the effects of a commercially available energy drink (Ghost®) compared to a caffeine-matched control on measures of mental and physical performance.

Methods: In a randomized, double-blind design, 62 participants were assigned to receive either the energy drink (Ghost®) or a caffeine-matched control (200 mg caffeine). Assessments were conducted at baseline and approximately 45 minutes post-ingestion, including the Psychomotor Vigilance Test (PVT), CNS Tap Test, handgrip strength, and the Profile of Mood States (POMS).

Results: Participant demographics are presented in Table 1. No significant between-group differences were observed for any performance measures. Both groups …