Digital Commons Network^™

Super-Fast, Super-Early: High-Frequency Oscillations May Be A Prelude To Alzheimer's Dementia In Down Syndrome, Manuel Silva-Pérez, Jeannie Chin

Faculty, Staff and Students Publications

Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, promising biomarkers of epileptogenicity, such as high-frequency oscillations (HFOs >250 Hz), have not been studied. This study is the first to use wideband polysomnography in DS to investigate if HFOs occurred and preceded AD dementia and LOMEDS. Methods: Wideband (0.1 to 500 Hz, 2048 Hz) polysomnography was performed using the international 10–20 system. HFOs were automatically detected during slow-wave sleep, followed by manual review. Results: Fourteen individuals with DS and five age-matched euploid …

Toward A Roadmap For Addressing Today's Health Dilemma-The 101-Statement Consensus Report, Katharina C. Wirnitzer, Mohamad Motevalli, Derrick R. Tanous, Clemens Drenowatz, Maximilian Moser, Holger Cramer, Thomas Rosemann, Karl-Heinz Wagner, Andreas Michalsen, Beat Knechtle, Zlatko Fras, Merel Ritskes-Hoitinga, Adilson Marques, Natasa Fidler Mis, Fatima C. Stanford, Christian Schubert, Nandu Goswami, Claus Leitzmann, Per Morten Fredriksen, Gerhard Ruedl, Doris Wilflingseder, Rodrigo A. Lima, Christian Kessler, Michael Jeitler, Naim A. Khan, Hassan Joulaei, Maryam Fatemi, Andrew Knight, Karl W. Kratky, Kara K. Palmer

School of Health Professions

Importance: In recent decades there has been an expansion in the quantity and quality of scientific findings and guidelines on different health topics to promote individual and public health status. Reports also indicate that there has been a simultaneous increase in the financial burden of disease, including trillions spent on healthcare resources by governments worldwide (predominantly in developing countries) to address health concerns. At the same time, personal health behavior is well-known as efficient and cost-free, holding four times the potential to prevent early death compared to health care. Despite this knowledge, data show that the increasing prevalence of unhealthy …

Revealing The Nervous System Requirements Of Alzheimer Disease Risk Genes In Drosophila, Jennifer M Deger, Shabab B Hannan, Mingxue Gu, Colleen E Strohlein, Lindsey D Goodman, Sasidhar Pasupuleti, Zahid Shaik, Liwen Ma, Yarong Li, Jiayang Li, Morgan C Stephens, Michal Tyrlík, Zhandong Liu, Ismael Al-Ramahi, Juan Botas, Chad A Shaw, Oguz Kanca, Hugo J Bellen, Joshua M Shulman

Faculty, Staff and Students Publications

Most Alzheimer disease (AD) susceptibility genes have poorly understood roles in the central nervous system (CNS). To address this gap, we systematically characterized 100 conserved candidate AD risk genes using a cross-species strategy in the fruit fly, Drosophila melanogaster. Genes were prioritized based primarily on human functional genomic evidence. We generated custom loss-of-function alleles for each of the conserved fly orthologs. Most of the genes are expressed in the adult brain, including 24 neuron- and 13 glia-specific expression patterns. Overall, we identify 50 candidate AD risk gene homologs with requirements for CNS structure or function, including 18 whose loss of …

Comparing Isocitrate Dehydrogenase Inhibitors With Procarbazine, Lomustine, And Vincristine Chemotherapy For Oligodendrogliomas, Gerardo Duran, Diego Pichardo-Rojas, Ahmed Hashim Ali, Peter Passias, Angela Downes, Wilson Z Ray, Gregory J Zipfel, Hakeem J Shakir, Andrew Bauer, Andrew Jea, Ian F Dunn, Jeffrey A Zuccato, Christopher S Graffeo, M Burhan Janjua

2020-Current year OA Pubs

The abstract has been submitted for presentation to the AANS 2026 meeting being held in San Antonio, TX, USA.

Brain Metabolic-Functional (De)Coupling From Health To Glioma Dysfunction, G Vallini, G Baron, E Silvestri, T Volpi, A G Vlassenko, M S Goyal, A Chiuso, D Cecchin, M Corbetta, A Bertoldo

2020-Current year OA Pubs

The interplay between brain metabolism and function supports the brain's adaptive capacity in cognitively demanding processes. Prior work has linked glucose metabolism to resting-state fMRI activity, but often overlooks both hemodynamic confounders in the BOLD signal and the brain's dynamic nature. To address this, we employed a novel effective connectivity decomposition, separating symmetric partial covariance, capturing "true" statistical dependencies between regions, from antisymmetric differential covariance, reflecting directional brain flow. In 42 healthy subjects, we show that partial covariance corresponds to metabolic connectivity across regions, while node directionality relates to standardized uptake value ratio, a proxy for local glucose consumption. We …

2017 Rocky Mountain National Park Research Conference, United States Department Of Interior

Rocky Mountain National Park

The work highlighted by this conference addresses key issues, including climate change, the spread of exotic plants, large scale restoration needs, environmental contaminants and disease, a need for greater relevancy to youth, and inadequate capacity to keep pace with growing visitation. The NPS Director's Order "Resource Stewardship for the 21st Century" directs park managers to steward resources for continuous change that is not yet fully understood. This challenge makes research, learning, and engagement at local to global scales more important than ever. The magnitude of issues and opportunities currently facing park managers is reflected in the breadth and depth of …

People And Nature And The Mountaintop, Ruth M. Alexander, Catherine Moore

Rocky Mountain National Park

A Resource and Impact Study of Longs Peak in Rocky Mountain National Park

Adamson, Stan; Alexander, James; Aspinall, Wayne; Bird, Isabella; Blaurock, Carl; Bossier, Floyd; Browser, David; Butler, William; Canfield, David; Carr, Ethan; Chapin, Frederick; Charles, Eliot; Clark, Gerald; Collier, Betty; Collier, Robert; Crouch, Dee; Daske, Larry; Davis, Earl; Disney, James; Diver, Van; Eubanks, Bill; Goss, Wayne; Grove, Jim; Hartzog, George; Herkinham, Norman; Holubar, Roy; Hurley, George; Jardine, Ray; Johnson, Dale; Johnson, Lydon Baynes; Kamps, Bob; Kezlan, Richard; Kiener, Walter; Kor, Layton; Lamb, Elkanah; Mclaughlin, John; Mills, Enos; Moomaw, Jack; Muir, John; Nesbit, Norman; Nugent, Jim;

Mountaineering In The Rocky Mountain National Park, Roger Toll, Robert Sterling Yard

Rocky Mountain National Park

Mountaineering in the Rocky Mountain National Park: Including a Map of the Park Circa 1917 and Various Photos

Olmstead, Frederick; Porter, Elliot; Powell, John Wesley; Rearick, Dave; Roosevelt, Teddy; Salaun, Milton; Shoup, Oliver; Stettner, Joe; Stettner, Paul; Toll, Roger; Ullman, James Ramsey; Vasille, Agnes Wolcott; Walker, Kris; Wallace, George; Wharton, John; Wirth, Conrad; Zimmerman, Weerner; Rocky Mountain National Park; Steads ranch; Steads Hotel; Estes Park; Cave of the Winds; Trail Ridge Road; MacGregor Ranch; Grand Lake; Long's Peak; Continental Divide; Boulderfield Hotel; High Trail Map; Wild Basin; Tahosa valley; Vale of Elkanah; Long's Peak Hotel;

Rocky Mountain National Park: Historical Background Data, Ross Holland Jr.

Rocky Mountain National Park

A study undertaken to furnish historical background information Rocky Mountain National Park for master planning. Includes photographs and a map.

Adams, Henry; Adams, Jane; Baker, William; Bird, Isabella; Bryan, William Jennings; Byers, William; Chubbock, Clarence; Churchill, Hiram; Colfax, Schuler; Cudahy, Edward; Darrow, Clarence; Dickinson, Anna; Estes, Joel; Estes, Milton; Evans, Griffith; Fall, Albert; Farrell, Ned; Garman, Samuel; Gaskill, L. D. C.; Godsmark, Joseph; Hague, Arnold; Hayden, F. V.; Howard, J. E.; Huges, Charles Evans; King, Clarence; Lamb, E. J.; March, M. E.; Mather, Stephen; McKelvey, Russell; Mills, Enos; Moomaw, Jack; Nichols, George; Nugent. James; Powell, John Wesley; Rigdon, John; Roosevelt, …

Rocky Mountain Administrative History, United States Department Of Interior

Rocky Mountain National Park

This study contains the administrative history of Rocky Mountain National Park from its creation in 1915 to 1965, fifty years. It is divided thematically into 13 chapters and a conclusion.

Trowbridge, Charles; Way, Claude; Toll, Roger; Rogers, Edmund; Allen, Thomas; Canfield, David; Miller, George; Doer, John; Lloyd, James; Hanks, Allyn; Liles, Granville; Novak, Fredrick; Thompson, Theodore; Dunning, Jimmy; Long, Stephen H; Dodge, Henry; Freemont, John; Vasquez, Louis; Sublette, Andrew; Estes, Joel; Estes, Milton; Teller, Henry M; Hollenbeck, Michael; Byers, William; Griffith; MacGregor, Alexander; Ferguson, Horace; James, W. E; Sanborn, B. D.; Stanley, F.O.; Wescott, Joseph L.; Proctor, Alexander; Proctor, Tirzah; …

Supporting Volunteerism In Virginia’S Free & Charitable Clinics, Rebecca Butler

Virginia Dental Journal

No abstract provided.

Virginia Board Of Dentistry Notes September 10, 2021, Ursula Klostemyer Dds, Ph.D.

Virginia Dental Journal

No abstract provided.

Nonmaleficence And Optimism, A. Garrett Gouldin

Virginia Dental Journal

No abstract provided.

Election Day Candidates For Governor Share Plans For Oral Health Policy

Virginia Dental Journal

No abstract provided.

Advocacyis It Dead In Virginia, Bruce Hutchison Dds

Virginia Dental Journal

No abstract provided.

New Member Campaign Highlights Safe Prescribing Procedures

Virginia Dental Journal

No abstract provided.

Is Your Practice Growing As Much As You Think It Should Be, Theresa Stenger

Virginia Dental Journal

No abstract provided.

Be A Media Star Interview Best Practices For Dental Health Experts, Cameron Mcpherson

Virginia Dental Journal

No abstract provided.

Through The Looking Glass, Sarah Glass Dds

Virginia Dental Journal

No abstract provided.

Dental Insurance - Is It Helping Or Holding Dentists Back, Gary Takacs

Virginia Dental Journal

No abstract provided.

2022 Annual Special Group Health Insurance Open Enrollment For Small Employers, Melanie Nowak

Virginia Dental Journal

No abstract provided.

A Year In Review, Frank Iuorno Jr., Dds

Virginia Dental Journal

No abstract provided.

Sea Change, Richard F. Roadcap Dds

Virginia Dental Journal

No abstract provided.

Va Dent J October, November And December 2021

Virginia Dental Journal

No abstract provided.

Rapid Ascent: Rocky Mountain National Park In The Great Acceleration: 1945-Present, Max Boxwell

Rocky Mountain National Park

A Master's Thesis asserting that wat-time technologies cheap fossil fuels, and a culture of techno-optimism—epitomized by the Mission 66 development program—helped foster a “Great Acceleration” of human alterations of Earth’s natural systems.

Abbey, Edward; Beau, Lucas; Braudel, Fernand; Carhart, Arthur; Collins, Kay; Condon, David; Contor, Robert; Crutzen, Paul; Fry, John; Guse, Neal; Hirt, Paul; Hughes, George; Keizer, Garret; Knous, Robert; Love, John Arthur; Menning, Edgar; Mills, Enos; Mooney, David; Noland, Jerry; Olson, Sigurd; Philpott, William; Redman, Mayme; Stoemer, Eugene; Sutter, Paul; Wirth, Conrad; Zalasiewicz, Jan; Leopold, Aldo; Rocky Mountain National Park; Rocky Mountains; Great Acceleration; Anthropocene; Spindletop; Tennessee Valley Authority; …

Gamification Of A Bimanual Coordination Task, Robby Johnson, Caeden Kidd, Johnathan Oestringer, Jaylin Pigeon, Brandon Woolman

Infinite Loop

Video games are a promising future for research and development. A new way to measure motor skills is to use robots to test individuals. This technology is incredible and has helped the medical field, but there must be a way to allow individuals to use this technology in a similar and affordable manner. Space Trash is a game that was developed with the intent to gamify the object hit detection that is used in the Kin Arm Robot with the intent to see if a person will show signs of Alzheimer’s. The goal is to not only be able to …

Navigating The Graduate Student Experience: Grit, Growth, And Persistence, Magdalen Kramer, Mitchell Buerkle, Heather Arlen, Ali Gravelle, Eli Bruess

The Journal of Advancing Education Practice

Graduate students navigate challenges in higher education with determination and tenacity. Postgraduate studies are enticing for career and personal advancement, but with an attrition rate of 12 – 26%, even the best students fail. The expectation and pressure to maintain high academic standards are often daunting. Many graduate students battle with emotional health and feelings of isolation, work-life balance, asynchronous learning, and other invisible factors, but still manage to find motivation to persist. We used personal experiences, information, and insight from our Winona State University leadership communication class to examine potential difficulties graduate students face. We backed our findings with …

Educating The Whole Child: The Essential Role Of School-Based Mental Health Partnerships In Student Success, Kellye Palmer

The Journal of Advancing Education Practice

Schools are uniquely positioned to serve as gateways for mental health access, yet many educational systems continue to treat mental wellness as secondary to academic instruction. This paper argues that school-based mental health partnerships are as essential to student success as physical education or standardized assessment. Drawing from the author’s experience coordinating behavioral health services within Baltimore County Public Schools, the discussion highlights how integrated partnerships between schools and clinicians reduce barriers to care, improve collaboration among educators and families, and foster early intervention. The paper also addresses the risks of unrecognized mental health needs being misidentified as behavioral or …

Listening To Families: A Perspective On Practice For Reframing Chronic Absenteeism Through Parent Voice, Anthony S. Felder

The Journal of Advancing Education Practice

Chronic absenteeism remains a critical issue in U.S. schools, particularly in urban communities disproportionately affected by poverty, trauma, and systemic inequities. Traditional attendance interventions often disregard the lived experiences of families, resulting in strategies that lack empathy and effectiveness. This perspective article draws on qualitative findings from parent focus groups conducted in a high-need urban district to emphasize what families believe schools should do to better support consistent attendance. Key themes highlight the necessity for practical resource support and two-way, trust-based communication between schools and families. Grounded in both practitioner experience and current research, this article presents actionable recommendations for …

Robert E. Howard: The Life And Times Of A Texas Author, Brandy Winn

Journal of Texas History

No abstract provided.