Digital Commons Network^™

An Innovative Hdm Model For Assessing Renewable Heat Energy Resources In Utility Energy Systems, Mark Alan Ryan

Dissertations and Theses

Renewable Heat Energy projects exhibit numerous unique, complex, and often conflicting characteristics, including varying project sizes, diverse energy resources, stakeholder demands, and significant challenges in energy conversion applications. Traditionally, cash flow analysis and return on investment are the most widely recognized metrics for evaluating remote energy projects. However, numerous quantitative and qualitative factors influence the overall performance and success of Renewable Heat Energy System (RHES) projects. A comprehensive approach using advanced tools is essential for assessing the factors and criteria that significantly impact these projects.

This research investigates the key quantitative and qualitative factors that contribute to the successful implementation …

Yap-Induced Glycolysis Drives Fibroinflammation And Disrupts Fibroblast Fidelity, Chang-Ru Tsai, Lin Liu, Yi Zhao, Jong H Kim, Paulo Czarnewski, Rich Gang Li, Fansen Meng, Mingjie Zheng, Jeffrey Steimle, Xiaolei Zhao, Francisco Grisanti, Zheng Sun, Jun Wang, Md Abul Hassan Samee, Xiao Li, James F Martin

Faculty, Staff and Students Publications

Background: Separation of the pulmonic and systemic circulation is essential for terrestrial life, and mammals have evolved distinct cardiac chambers with specialized structures and functions. Transcriptomics profiling revealed cellular heterogeneity between heart chambers. However, the mechanisms underlying chamber-specific transcriptomic and metabolic differences-and their functional significance-remain poorly understood. The Hippo/YAP (yes-associated protein) pathway is a conserved signaling network that regulates diverse cellular processes. The Hippo kinases inhibit YAP in cardiac fibroblasts (CF) to restrict fibrosis and inflammation. Nonetheless, how YAP regulates the metabolic microenvironment during homeostasis and fibroinflammation remains unclear.

Methods: We investigated YAP and glycolysis activity in the 4 cardiac …

Pitx2 Dosage-Dependent Changes In Pacemaker Cell State Underlie Sinus Node Dysfunction And Atrial Arrhythmias, Lieve E Van Der Maarel, M Ridwane Mungroo, Otto J Mulleners, Mathilde R Rivaud, Arie O Verkerk, Karel Van Duijvenboden, Freek H T Tiel Groenestege, Jeffrey D Steimle, Lianne Fokkert, Corrie De Gier-De Vries, Mischa Klerk, Arie R Boender, James F Martin, Bjarke Jensen, Gerard J J Boink, Harsha D Devalla, Vincent M Christoffels

Faculty, Staff and Students Publications

Physiologically relevant increases in transcription factor dosage and their role in development and disease remain largely unexplored. Genomic deletions upstream of the Paired-like homeodomain transcription factor gene (PITX2), identified in patients with sinus node dysfunction and atrial fibrillation and modeled in mice (delB), rewire the local epigenetic landscape, increasing PITX2 expression. Here, we demonstrate that pacemaker cardiomyocytes in the embryonic delB sinus node ectopically express PITX2 at physiological dosages in a heterogeneous pattern. The prenatal delB sinus node forms discrete subdomains showing PITX2 dosage-dependent mild or severe loss of pacemaker cardiomyocyte identity. Respective subdomain sizes and severity of sinus node …

Dinaciclib Improves Treatment Response In Chemoresistant Hepatoblastoma, Brian T Hickner, Andres F Espinoza, Rohit K Srivastava, Roma H Patel, Priyanka Rao, Nicholas A O'Brien, Kalyani R Patel, Andrew A Badachhape, Abhishek Kona, Dolores H López-Terrada, Sarah E Woodfield, Sanjeev A Vasudevan

Faculty, Staff and Students Publications

Chemoresistant hepatoblastoma (HB) is associated with poor outcomes. Cyclin-dependent kinases (CDKs) are potential therapeutic targets because of their critical role in cell growth and chemoresistance. To evaluate the efficacy of CDK inhibition, HB cell lines were treated with dinaciclib and evaluated with cytotoxic, cell-death reversal, and immunoblotting assays. A HB patient-derived xenograft (PDX) model was treated with placebo, vincristine + irinotecan (VI), dinaciclib, or VI + dinaciclib to evaluate tumor growth and response to therapy. We found that dinaciclib had a marked effect on HB cell viability, induced PARP cleavage, and decreased CDK9 protein expression in vitro. Overexpression of CDK9 …

A Mouse Model Of Lipoatrophy Reveals Relationships Between Beige Fat Appearance And Female Fertility, Elizabeth S Anaya, William Dion, Pradip K Saha, Aaron R Cox, Evelyn De Groot, Avery A Ahmed, Jessica B Felix, Bokai Zhu, Stephanie A Pangas, Sean M Hartig

Faculty, Staff and Students Publications

White adipose tissue (WAT) performs vital metabolic and endocrine functions, but roles in female reproduction remain understudied and poorly understood. Here, we report that female mice experiencing progressive lipoatrophy after knockout of Ubc9 in adipocytes (Ubc9fKO) displayed disrupted estrous cycles, reduced ovarian reserve, and subfertility. During aging, female Ubc9fKO mice lose subcutaneous WAT more quickly than their male counterparts and weigh less than littermate controls. Subcutaneous WAT excised from female Ubc9fKO mice strongly enriched for thermogenesis genes generally associated with metabolic benefits. Female Ubc9fKO mice exhibited hypermetabolism and accumulated thermogenic, Uncoupling Protein 1-expressing beige fat cells in residual subcutaneous WAT …

A Comprehensive Study Of C-Kit-Expressing Amacrine Cells In The Mammalian Retina, Zheng Jiang, Wen Shen

Faculty, Staff and Students Publications

Amacrine cells assemble complex circuits in the inner retina, where they integrate, modulate, and relay spatial and temporal information to retinal ganglion cells. Nevertheless, their organization and functional diversity are still not fully understood. In this study, we identify a distinct group of amacrine cells that express the stem cell factor receptor-c-Kit. Using combined techniques of anti-CD117 (c-Kit) immunolabeling, confocal imaging, and computational algorithms, we characterize the morphological features and spatial distribution of the c-Kit-expressing amacrine cells. Our results show that c-Kit-expressing amacrine cells are GABA-positive neurons with medium to wide dendritic fields that stratify within the specific strata in …

The Power Of Positive Lesbian Representation In Television: How It Affects The Well-Being And Identity Formation Of Lgbtq+ Adults, Brittany Berry

University Honors Theses

To date, there are no studies which explore the effects that positively represented Black and lesbian characters in television have on LGBTQ viewers. Exposure to LGBTQ characters has the potential to validate LGBTQ identities and improve well-being. A comprehensive literature review and quantitative analysis using Żerebecki et. al.'s codebook reveals there are simply not enough characters depicted to provide such research. In an attempt to demonstrate the qualities possessed by positively portrayed Black, lesbian characters, this study analyses Taissa Turner from the hit series Yellowjackets available on the streaming network Paramount+.

Human Evil (In The Weird), Lucas Ethridge

University Honors Theses

This paper examines a trending doom in speculative fiction: the post-human age. Many modern works have started to look past human civilization as humans surrender all hope and faith in a climate-doomed world. Honing in on core concepts in Weird fiction, this paper explores human merit through Old and New Weird. A good part spends time establishing the canon, looking at similar patterns across age, philosophy, war and genre. The chief question asks if humankind was ever worth saving.

Synergistic Potential Of Sipuleucel-T In Enhancing Immunotherapy For Metastatic Castration-Resistant Prostate Cancer, Kavita Rawat, Varnika Punia, Parker Mathews, Sara Mccoy, Wilbur Song, Muhammad A Saeed, Russell K Pachynski

2020-Current year OA Pubs

Clinical trials of immunotherapy in metastatic castration-resistant prostate cancer (mCRPC) have largely been unsuccessful despite promising preclinical studies and proven efficacy in other solid tumors. These disappointing clinical outcomes have been attributed to an immunosuppressive tumor microenvironment, a relative lack of infiltrating immune effector cells, and tumor-related and host-related factors, which collectively render prostate cancer a relatively immunologically "cold" tumor. Sipuleucel-T (Provenge), an autologous cellular immunotherapy, induces an immune response targeted against prostatic acid phosphatase. It received approval from the US Food and Drug Administration in 2010, marking the first immunotherapy to show an overall survival benefit in patients with …

Patient-Centered Televisit For Chronic Obstructive Pulmonary Disease Discharge Transitions: User-Centered Design Study, Joanna Abraham, Alicia Meng, Nicolas Caravelli, Leah Traeger, May Nguyen, Vineet Arora, Valerie G Press

2020-Current year OA Pubs

BACKGROUND: Chronic obstructive pulmonary disease (COPD) affects approximately 16 million Americans and often results in avoidable readmissions due, in part, to medication errors and lack of education. Telehealth interventions can support medication reconciliation and inhaler education following hospital discharge for patients with COPD.

OBJECTIVE: This study aimed to design and prototype TELE-TOC (Telehealth Education: Leveraging Electronic Transitions of Care), a post-discharge, in-home, televisit intervention, and to map its workflow to ensure integration into the routine discharge care transition process for patients with COPD.

METHODS: A user-centered design approach across 3 phases was followed to develop and prototype TELE-TOC. Participants included …

Chemical Profile Of Earthworm Flour With Kasgot Media Enriched With Cow Blood And Date Pulp, Ikrima Ahdavia, Imra Atun Helmi, Hidayati Nufus, Muhammad Farid, Ahmad Sjahriza

Chimica et Natura Acta

Fish meal is used as an ideal protein source for feed with a high level of digestibility but its limited and costly. This study explores earthworm flour as an alternative protein source, cultivated in kasgot (maggot residue) media enriched with organic waste. The novelty of this research lies in using maggot residue as the living medium for earthworms, enhancing the nutritional value of the earthworm flour, making it more beneficial and suitable as an additive protein feed ingredient. The kasgot medium was formulated by mixing boiled cow blood with date pulp fermented with EM4 probiotics in three different ratios: 2:1 …

School And District Leaders’ Understanding Of Technology Organizations’ Cyber Business Practices, Jayejaye Johnson

Journal of Educational Research and Practice

Educational technology (EdTech) interoperability throughout cyberspace provides the financial opportunity to collect and sell student privacy information in digital learning environments, challenging school leaders to govern schools and keep children safe. School leaders provide the resources, funding, planning, decision making, and administration for EdTech cybersecurity practices and policies, yet little is known about what public school leaders understand. A quantitative study was designed using primary data collected from an online survey. Four research questions guided this study: What are the differences in cybersecurity practices and policy response scores (1) between male and female school leaders; (2) among leaders with different …

Child Assent Practices In Research: Improving Ethics, Decision-Making, And Inclusivity, David C. Coker, Ketaki Inamdar, Daniel F. Mccleary, Lesley Cottrell

Journal of Educational Research and Practice

The following article addresses a conundrum: What if child assent in research were a fully informed, stand-alone process that empowered all children to discuss meaningfully, negotiate, and decide how and what the research experience would look like? Past research and practices suggest that child assent, when children (youths to 17-year-olds who have not been emancipated) agree to participate in research before, during, and after parents’ or guardians’ consent, is rife with problems that minimize informed participation and prize procedural ethics over true understanding of the processes and autonomous decision-making. Academic articles often lack details, as length requirements and brevity preclude …

Create @ State 2011, Arkansas State University - Jonesboro

Create@State

The proceedings book for 2011

Enhancing Archives And Records Management In Low-Resourced Organizations Through Experiential Learning, Jinfang Niu

Journal of Contemporary Archival Studies

Master’s students in Archives and Records Management could help low-resourced organizations address their Archives and Records Management needs while gaining practical experience. Archives and Records Management education programs could facilitate this mutually beneficial relationship by offering internships and service-learning courses. This paper analyzes the strengths and limitations of these two experiential learning mechanisms and discusses solutions to overcome the limitations. It argues that service-learning is especially suitable for addressing the Archives and Records Management needs of low-resourced organizations and proposes a service-learning model for that purpose.

The Relationship Between Emotional Intelligence And The Practices Of Servant Leadership In The Kingdom Of Saudi Arabia, Rajeh Bati Fahad Almasradi

UB Journal for Humanities

The current study aimed to identify the relationship between emotional intelligence and servant leadership practices among health sector employees in the Asir region in the Kingdom of Saudi Arabia. Emotional intelligence was studied as an independent variable and servant leadership as a dependent variable. This study also investigates the relationship between emotional intelligence and the four dimensions of servant leadership: (conceptual skills/empowerment, emotional processing and care for others, and community development. The descriptive analytical approach was used, and the questionnaire tool was applied to collect data from the study population. A random sample representative of the study population was selected. …

Exploring The Intricate Relationship Between Automation And Performance In The Saudi Public Sector., Saleh Hamed Alharbi

UB Journal for Humanities

Office automation immensely enhances the working environment. Widespread technological revolution shapes Human Resource Management (HRM) practice. The most important factor in decision-making is the information on which the decision is based. Detailed and accurate information prevents erroneous decisions. This study explores the impact of the automation of HR processes on organizational performance in the public sector. Three hundred and sixteen (316) employees from the University of Tabuk participated in the study. The study used smart Partial Least Squares–Structural Equation Model (smart PLS-SEM) to estimate the relationships between constructs. The results reveal that office automation has a direct impact on organizational …

Exploring The Impact Of Talent Management Strategies On Improving Healthcare Service: A Case Study On King Faisal Medical Complex In Taif, Wejdan Mabrook Abdullah Al-Otaibi, Osama Abdelmonge Yousef Akola, Sami Ahmed Saleh Alghamdi

UB Journal for Humanities

The current study aims to identify the role of talent management in improving the service of healthcare service. To achieve the objectives of the study, the researchers relied on the descriptive analytical approach. A questionnaire was administrated employees at King Faisal Medical Complex (KFMC) in Taif - Kingdom of Saudi Arabia. The researchers received back 230 responses. Results show that the respondents agreed highly on the imperative role of talent management, with an average score of 76.96%. There was a positive correlation was (r=0.4835), between the dimensions of talent management and the improvement of the healthcare service. The results also …

Program Book 2025, Kari Harris

Arkansas Liberal Arts and Humanities Day

The program book for the inaugural Arkansas Liberal Arts and Humanities Day held on November 13th, 2025 in the Arkansas State Capitol building in Little Rock.

Creating Your Own Way, Sharline G. Vanpelt

Arkansas Liberal Arts and Humanities Day

Trompe L’oeil is a term in Art History often associated with creating a painting so realistic that it tricks the viewer into believing it is real. Producing a Trompe L’oeil required extensive training in art academies, and historically, ownership of such works was limited to wealthy or upper-class individuals, as the craft was highly valued and expensive. This notion is present in today’s art world and raises questions about who can access and own art, and whether fine art is accessible to the public.

This context informs my demonstration, which explores new technologies in painting and sculpture that enable material-based …

The Families Of St. Mary Abbots Church, Kensington, Middlesex, England, Darrah S. Thompson

Arkansas Liberal Arts and Humanities Day

ABSTRACT:

This case study represents the lives of families who resided in the area surrounding St. Mary Abbots Church, located in Kensington, Middlesex, England, in the early nineteenth century. By analyzing baptismal records and the geographical landscape of Kensington Parish, everyday lives are traced through the social and economic impact of London's industrialization and urbanization. With a slight glimpse into the possible family bonds and health impacts on each family, a clarified picture is painted of the trials that adults and children experienced during this period. The shift from rural villages to suburban communities incorporates steep class divisions while simultaneously …

A Cord Of Three Strands Is Not Quickly Broken, Laura L. Hennings

Arkansas Liberal Arts and Humanities Day

Throughout the twentieth century, women's activism in Arkansas existed on a spectrum. From sweeping, state-wide movements to incremental shifts in local policy, many women united across racial lines and socioeconomic differences to bring about positive change for all Arkansans. Thousands of unnamed rural women worked directly and indirectly with public figures such as Adolphine Fletcher Terry and Daisy Bates to improve access to healthcare, education, and a better quality of life. For these women in Arkansas, I argue that the intersectional nature of their activism is precisely the reason for their greater successes.

The Public Duty Doctrine & State Governmental Tort Liability: A Brief History And A Solution For The Current Paradigm, Cooper Harrison

University of Memphis Law Review

In the early morning hours of Friday, September 2, 2022, a young woman named Eliza Fletcher was jogging down Central Avenue in Memphis, Tennessee when a man violently abducted her.2 Shortly after the abduction, the Memphis Police Department issued a city-wide watch for Mrs. Fletcher, volunteers searched wooded areas around town, and news outlets broadcasted the few known details of her abduction.3 Mrs. Fletcher disappeared near the University of Memphis Campus just a few hundred feet from a local private school, providing police with a cache of surveillance footage that helped them quickly pinpoint a suspect.4 On September 3, just …

Sexual Orientation, Rank, And Status, Duane Rudolph

University of Memphis Law Review

Dignity retains its ancient focus on rank and status. This Article, therefore, rejects the idea that we now live in the age of equal dignity, meaning equal rank and status for everyone. Rank underscores numbering, placement, and position in a predetermined hierarchy, and status underscores the power and privileges associated with each rank. Rank permits human beings to identify their preassigned location in the hierarchy, and status justifies assertions of rank since status governs the ancestral privileges, powers, and responsibilities attached to each rank. The Article relies on two constitutional cases, one before “dignity” and the other after. In 1986, …

Empowering The People Of The Developing World

Vision and mission statements

No abstract provided.

Importance Of Nature In A Technological World, Cameron Cooley

Philomathean

No abstract provided.

The Indiana Statesman, December 4, 2025, Indiana State University

Student Newspaper

Finals Week Schedule; The Pocket Galleries: one day only; Honors Students present research during Study Week

'The Rest Is Silence': Reframing Stasis As Integral To Creative Practice, Corinna Di Niro, Pablo Muslera

Staff Scholarship - Australia & Dubai

This duoethnographic study examines the relationship between motion and stasis in creative practice through the lens of two creative educators working in postgraduate and undergraduate Creative Industries. Drawing on our combined experiences as practitioners and educators at SAE University College, we explore how creative blockages can be reframed as productive rather than problematic, challenging dominant productivity paradigms in contemporary creative industries and education. Through structured dialogic exchange, we investigate three interconnected themes: the rhythmic nature of creative practice, the pedagogical value of embracing productive stasis, and the tension between institutional timelines and creative development. We consider how encouraging SAE creative …

All Of Us Live In Texas, But Our Friends Hang Their Hats In New Zealand, Augusta Arata, Irene L. Flores, Angel Castillo, Robert Hoilman, Donald D. Sanders Ii

Sociology and Anthropology Student Research - Archive

Cultural similarities and differences between New Zealand and Texas through an anthropological perspective. The zine focuses on cuisine, sports, consumerism, and lifestyle choices.

Staff Education For Enhancing Providers’ Knowledge Of Long Acting Injectables (Lais) Antipsychotics In The Outpatient Mental Health Clinic, Belinda Okoruwa

Walden Dissertations and Doctoral Studies

This doctoral study is a quality-improvement educational program in an outpatient mental health clinic designed to address the underutilization of long-acting injectable (LAI) antipsychotics due to gaps in providers’ knowledge. The project question centered on whether structured education on LAIs antipsychotics increases providers’ knowledge in an outpatient mental health setting. The purpose of this project is to increase LAI antipsychotic utilization by educating providers about the advantages, safety, and appropriate administration to promote consistent implementation. In this project, I used a single-group pre/post design including six participants, incorporating a 12-item questionnaire and 5-point Likert scale questions (Not at all/Somewhat/Very Much). …