Digital Commons Network^™

Motivating And Retaining Alabama Band Directors: A Comparison Of Rural, Suburban, And Urban Band Directors, Brandon Jay Benson

Doctoral Dissertations and Projects

Despite existing challenges in rural, suburban, and urban communities, band directors face a lack of motivation due to burnout and insufficient resources. This study examines the motivational factors of forty-two Alabama band directors who teach in rural, suburban, and urban communities. Guided by a correlational research design, this mixed-method research study identifies motivational factors that still need to be explored to highlight the motivational factors that drive band directors to continue teaching in their current Alabama communities. This study explores the motivational factors of forty-two Alabama band directors based on their responses to a Likert-type survey and emailed interview questionnaire. …

Methods For The Discovery Of Antibodies Toward Junin Virus Utilizing Yeast Surface Display, Jonathon E. Corral

Doctoral Dissertations and Projects

The importance of this study is to perform antibody discovery as a means to derive novel preventative and therapeutic antibody countermeasures against the Junín virus, to alleviate the potential risk of a global pandemic. The purpose of this methodological study was to develop a protocol that utilizes yeast surface display to discover antibodies, from naïve human antibody libraries, that can bind the Junín Virus antigen. The methodology of yeast surface display employs the galactose-inducible GAL1 promoter to synthesize and express antibody proteins bound to the Aga2p and Aga1p and anchored to the cell wall by glycosyl phosphatidylinositol motif (GPI). The …

Brainspotting And The Strong Black Woman Schema: A Pretest–Posttest Study On Psychological Wellness, Iiesha Lasha Ricks

Doctoral Dissertations and Projects

Black women in the United States experience disproportionate health disparities resulting from the intersecting effects of racism and sexism. Although researchers widely acknowledge these disparities, they have given less attention to how race- and gender-based oppression affect mental health outcomes. Brainspotting (BSP) is a trauma-informed approach emphasizing clinician attunement and a nonjudgmental space for processing distress. While BSP has shown promise with diverse populations, few studies have specifically examined its use with adult Black American women. This quantitative pretest–posttest study investigated the efficacy of BSP in improving psychological wellness among Black women and whether endorsement of the Strong Black Woman …

The Lived Experiences Of Implementing Social-Emotional Learning Competencies In The Classroom Of Teachers In A Southern State: A Phenomenological Study, Lakenya King

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore the lived experiences of teachers in a southern state who implemented social-emotional learning (SEL) competencies in the classroom. The study was guided by Goleman's theory of emotional intelligence (EI), which focused on SEL needs and benefits. The central research question was: What are the lived experiences of teachers who implemented SEL competencies in the classrooms in a southern state? This study used a transcendental phenomenological design to gain insight into the phenomenon from 10 teachers in a public district in a southern state who implement SEL competencies in the classroom. …

The Lived Experience Of Students With Neurodevelopmental Disabilities And Smartphones For Higher Learning, Eric F. Sandstrom

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to describe the lived experiences of college students with neurodevelopmental disabilities (NDD) using smartphones for online learning during historic levels of both enrollment of students with NDDs and smartphone use in education. The guiding framework is Bandura's (1986) social cognitive theory, which explains how learning occurs in a social context that includes interpersonal, behavioral, and environmental factors. This study asks: What are the lived experiences of students with NDDs in college using smartphones for online learning? The study seeks to understand how smartphones influence students’ perceptions of disability accommodations, internal locus of control, …

Why Not Me: Increasing Black Male Participation In Church Leadership, Veronica Ojo

Doctoral Dissertations and Projects

This ethnographic qualitative study aimed to understand how the volunteerism and service of young Black males between the ages of 18 and 25, who were raised in and currently attend African American Baptist churches in the State of Georgia, are influenced by Transformational Leadership behavior. During the research, volunteerism and service were defined as those who participated or were connected to church ministries within their home church. The theory guiding this study was Burns’s (1978) transformational leadership theory as it relates to the behavior behind senior pastors’, youth ministers’, and senior church leaders’ mentorship of young Black males for leadership, …

Church Hurt: A Phenomenology Of The Lived Experience Of African American Christians, Danny Streeter

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the lived experiences of African American Christians in the Mississippi Delta who have experienced church hurt in the Black Church. The theory guiding this study was Abraham Maslow’s Hierarchy of Needs, which consists of five levels of needs: physiological, safety, love, esteem, and self-actualization. This study addressed the following research questions: How do African American Christians in the Mississippi Delta describe their experience with church hurt in the Black Church? How do African American Christians in the Mississippi Delta describe their relationship with the church after their church-hurt experience? How do …

Building Belonging: Designing A Training Program To Foster Inclusion In Children's Ministry, Amanda J. Lemieux

Doctoral Dissertations and Projects

The strategic problem aims to address how to train volunteer children’s ministry workers to feel more confident and well-equipped to handle children with diverse needs. Paul wrote in Romans that one should be accepting of all people just as Jesus accepted (Rom. 15:5-7). Humanity is created in the very image of God, the Creator. It is essential to recognize that everyone is created in God’s image and, therefore, deserves to be treated as such (Gen. 1:27). A healthy children’s ministry should ensure that all children are not only welcome within the classroom but also taught in a way that they …

Employee Commitment, Engagement, And Performance When Shifting To A Virtual Workplace, Ariyana C. Brown

Doctoral Dissertations and Projects

The COVID-19 pandemic contributed to the accelerated implementation of remote work, leading to a decline in employee attitudes toward organizational commitment and productivity following the shift to a virtual workplace. This shift has resulted in high turnover rates and difficulty achieving continued success. Previous research has focused on the impact of remote work on employee productivity but lacks data showing how to improve employee attitudes toward commitment in a remote work environment. This study used a fixed design with correlational methods to determine how employee attitudes toward commitment have been affected by the shift to a remote workplace, leading to …

The Impact Of Street Medicine Programs On Addressing Poor Health Outcomes In Unhoused Populations, Lori R. Kelley

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand the problem of poor health among unhoused populations based on the perspectives of outreach workers and shelter staff. This study was conducted in Monroe County, Indiana. The theory guiding this study was social ecological theory by Urie Bronfenbrenner. Social ecological theory was used to understand how social ecological layers impact poor health in unhoused populations. Hermeneutic phenomenology was used with purposive maximum variation sampling to gather seven study participants with lived experience of working with unhoused populations. Data collection included one-on-one interviews, observation, and documentation review. After data collection was completed, …

A Transcendental Phenomenological Study Of The Influence Of Leadership Styles On Teacher Retention In Rural Schools In South Carolina, Kayla Francena Carter

Doctoral Dissertations and Projects

This transcendental phenomenological study explored the influence of principal leadership on teacher retention in rural schools in South Carolina. Grounded in the theoretical framework of self-efficacy, the study examined how specific leadership behaviors and practices shape teachers' decisions to remain in or leave their positions. The central research question guiding this study was: How does a principal's leadership style impact teacher retention in rural areas in South Carolina? A purposeful sample of 12 certified elementary, middle, and high school teachers with at least three years of experience working in rural schools participated in the study. Data was collected through open-ended …

Play, Instruct, Lead: Investigating The Influence Observing Same-Gender Role Models Has On Leadership Development Of Collegiate Women Student-Athletes Coaching At Youth Sports Camps: A Phenomenological Study, Mercy-Nora Osei

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to describe how observing same-gender role models influenced the leadership development of collegiate women student-athletes (CWSA) when coaching at youth sports camps (YSC) at NCAA institution campuses in the United States. The theory that guided this study was Albert Bandura’s theory on social learning, as it explained the relationship between observational learning and the influence role modeling had on leadership development. The central question was: How does observing same-gender role models influence the leadership development of collegiate women student-athletes when coaching at youth sports camps? This study used a transcendental phenomenological design to …

Workplace Violence: A Paradigm Shift, Ann Marie Hutchens

Doctoral Dissertations and Projects

Workplace violence (WPV) has reached epidemic proportions. WPV poses devastating results on the healthcare industry: affecting quality of care and patient outcomes, contribute to the development of physical and psychological conditions for nurses, and reduce the healthcare teams’ level of job satisfaction and organizational commitment. The United States is already facing a nursing shortage due to baby boomers retiring and an increase chronic disease and the elder population. Although strongly prevalent, WPV is significantly underreported. It is believed that the low rate of reporting is a consequence of apathy that violence is an occupational hazard, and that nothing will change. …

Structured Project Prioritization Process In Higher Education Institutions, Maura Vidal

Doctoral Dissertations and Projects

This qualitative study explored structured project prioritization processes within higher education institutions in California to address challenges in resource allocation and alignment with strategic objectives. Guided by general systems theory and a pragmatic research paradigm, the study used a flexible research design with case studies and semi-structured interviews involving project managers, portfolio project managers, and administrators. Thematic analysis revealed three key findings: institutions faced significant challenges in prioritizing projects due to competing stakeholder interests, limited resources, and unstructured decision-making; those using structured prioritization methods, such as multi-criteria decision tools and portfolio reviews, achieved better alignment with strategic goals and reduced …

From Theology To Practice: A Faith-Based Financial Literacy Program For Church Leaders And Congregants, Jacklyn Morrison

Doctoral Dissertations and Projects

This Dissertation-in-Praxis addresses the pressing need for financial literacy within church communities by developing a faith-based financial education program tailored for Reignited Worship Center in Las Vegas, Nevada. Despite the abundance of biblical teachings on stewardship, many churches and their members experience chronic financial instability, limiting ministry effectiveness and personal well-being. The praxis project identifies a gap between theological understanding and practical financial management among African American congregants, exacerbated by systemic economic challenges and limited educational resources. Guided by biblical principles and a holistic ministry approach, this study proposes a comprehensive program integrating scriptural stewardship with practical financial tools. The …

Perceptions Of Educators Of Native American Students In Special Education And Why They Were Placed In Special Education, Megan N. Rose

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand the lived experiences of educators of Native American students related to the disproportionality of Native American students who are placed in special education in a school in the Southeastern U.S. The theory that guided this study was critical race theory and its relationship to the disproportionality of Native American students being placed in special education. The central research question that guided the study was: What are educators' experiences with the placement of Native American students in special education? The participants included eleven teachers of Native American students who were placed in …

Dance Movement For Wounded Warriors With Mental Health Diagnoses: A Phenomenology, Amelia Ann Forsmo

Doctoral Dissertations and Projects

The purpose of this phenomenological study will be to understand how dance movement can improve the psychological health of military veterans who are experiencing a mental health disorder such as posttraumatic stress disorder. The theories guiding this study are Carl Rogers’ humanistic perspective, Schlossberg’s transition theory, and the post-traumatic growth theory. A purposive sample of 12 to 15 veterans will be selected for participation in this study. Each veteran will have different military backgrounds, various battle wounds, and unique experiences with dance movement or dance movement therapy. For this reason, these perspectives allow each participant to be prioritized and heard. …

Predicting The Attitudes Towards Mathematical Modeling Of Primary Math Teachers: The Role Of Self-Efficacy And Motivation, Brenden Rawls

Doctoral Dissertations and Projects

The purpose of this non-experimental quantitative predictive correlational study was to investigate the extent to which efficacy for pedagogy in mathematics, efficacy for teaching mathematics content, effectance motivation in mathematics, years of experience, and access to statistics, data science, or mathematical modeling courses predict attitudes toward constructivist practices in mathematical modeling of Virginia primary school mathematics teachers. The goal of the research was to understand what affective characteristics support effective adoption Virginia's mathematics curriculum change. Higher levels of mathematics teacher self-efficacy have been associated with constructivist instructional practices and higher levels of student achievement. The sample included kindergarten through fifth-grade …

Nursing Home Leadership And The Connection To Fostering Quality Care In Nursing Homes, Daphne Hicks

Walden Dissertations and Doctoral Studies

Nursing homes in the U.S. state of Mayland experience a high volume of reports for abuse and neglect and are poorly ranked for responding to complaints, leading to a low overall rating. The purpose of this qualitative study was to explore leadership practices that could result in improvement in quality of care and reductions in abuse and neglect, using a needs assessment and development of a logic model as a precursor for a formative evaluation. The framework applied was Lead Self, Engage Others, Achieve Results, Development Coalitions, and Systems Transformation. Eight nursing home administrators were interviewed to collect primary data, …

A Collaborative Leadership Development Model For Classical Christian School Consortiums, Lisa Diane Smith

Doctoral Dissertations and Projects

Over 55% of young adults in the United States have experienced some form of leadership development; however, their leadership skills are not being used within the church. Nearly 60% of those who regularly attended church during their youth are distancing themselves from it (Barna, 2023). Nonetheless, the same report suggested a link between youth who were well-integrated into a youth ministry and those who stayed active in the church. This Praxis program partnered with Redeemer Classical Academy to implement a Christ-centered leadership development initiative for its high school students. The argument supporting the Praxis program indicates that grounding students' leadership …

Mbnl Loss Of Function In Smooth Muscle As A Model For Myotonic Dystrophy Associated Gastrointestinal Dysmotility, Janel A M Peterson, Jesus A Frias, Andrew N Miller, Krishnakant G Soni, Yi Zhang, Zheng Xia, John W Day, Geoffrey A Preidis, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy and severely affects multiple organ systems, including the brain, heart, skeletal muscle, and gastrointestinal (GI) tract. Despite 80% of individuals with DM1 experiencing GI dysfunction that affects their daily life, the mechanisms of GI dysmotility in DM1 remain an understudied aspect of the disease. DM1 is caused by a CTG repeat expansion in the DMPK gene that, when expressed as an expanded CUG repeat RNA, sequesters and reduces the activity of the muscleblind-like (MBNL) RNA-binding protein family. We developed a mouse line with conditional, smooth muscle-specific knockout of …

Molecular Effects Of Glucose On Mir503hg-Regulated Genes In Triple-Negative Breast Cancer, Victoria Reid, Barbara Yang, Kyle Russo, Melina J. Sedano, Ramesh Choudhari, Enrique I. Ramos, Shrikanth S. Gadad

School of Medicine Publications

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by a lack of key hormone receptors in tumor cells. As there are limited treatment options for these patients, it is crucial to understand the underlying mechanisms by which TNBC constantly evolves and evades treatments. In this regard, the pervasive nature of transcription provides a potential reservoir of transcripts, including both coding and noncoding, that TNBC leverages to sustain a proliferative advantage and support tumor growth. TNBC is affected by energy sources such as glucose, which can have a profound impact on gene expression regulation mediated by various …

Neuropathic Pain And Related Depression In Mice: The Effect Of A Terpene And A Minor Cannabinoid In Combination, Jose Rios, Mohammed Alnoud, Mohammad Hussain, Zayd Ayas, Emmanuel Franco, Justin D. Mills, Joshua Nwose, Maria Sophia Malbas, Hiram L. Garcia, Manish Kumar Tripathi, Khalid Benamar

School of Medicine Publications

Background/Objectives: Neuropathic pain is one of the most severe types of chronic pain. Although it is difficult to manage, it often co-occurs with depression. Yet, no medication addresses the neuropathic pain and depression comorbidity. Therefore, developing integrated treatment strategies that address both pain and depression is a major public health priority and an unmet need affecting millions. Methods: In this study, we investigated the effect of combining a terpene, Beta-Caryophyllene (BCP), and cannabidiol (CBD) on neuropathic pain and associated depression. We employed a chronic constriction injury (CCI) neuropathic pain model and a series of behavioral tests to evaluate …

Intracranial Injection Of Genetically Modified, Mosquito Non-Transmissible Zika Virus: Safety In Primates And Ramifications For Brain Tumor Therapy, Alec J Hirsch, Amanda De Andrade Costa, Emilie Russler-Germain, Ashwani Kesarwani, Yuping Li, Michael S Diamond, Milan G Chheda, Et Al.

2020-Current year OA Pubs

Glioblastomas (GBMs) are incurable brain tumors. Zika virus (ZIKV) has specificity in killing GBM stem cells, which drive treatment resistance. In mouse models of GBM, ZIKV also generates an anti-tumor inflammatory response and prolongs survival. To support clinical development and address safety concerns for intra-tumoral treatment, we assessed the effects of injection of an immune-sensitized ZIKV (Δ10 3'-UTR ZIKV), which cannot be transmitted by mosquitos, into non-tumor-bearing rhesus macaque brains. After injection, the primates showed no clinical signs of illness. Histologically, as expected, ZIKV infection elicited mild inflammation, which resolved within 2 weeks. No infectious virus was detected in the …

Wdfy4-Dependent Cross-Presentation Proceeds Via A Vacuolar Antigen-Processing Route, J Luke Postoak, Alyssa Koch, Sicong Shan, Ray A Ohara, Suin Jo, Jing Chen, Pritesh Desai, Feiya Ou, Magdalena Kraft, Michael S Diamond, Sunkyung Kim, Theresa L Murphy, Kenneth M Murphy

2020-Current year OA Pubs

The intracellular processing route used by type I conventional dendritic cells (cDC1) for cross-presentation of viral- or tumor-associated antigens remains controversial. One model proposes that captured antigens exit from damaged phagolysosomes and enter the cytosol, where they are processed for presentation by MHC class I molecules (MHC-I). This model relies on proteasomal degradation and TAP-dependent peptide transport into the endoplasmic reticulum (ER) for loading by the peptide loading complex (PLC). An alternative model proposes a vesicular route in which captured antigens are retained and processed within an endocytic compartment. A compelling argument favoring the cytosolic model is the dramatic loss …

Intracellular Acinetobacter Baumannii Acts As A Transient Reservoir In Lung Infection Via A "Persist And Resist" Strategy, Manon Janet-Maitre, Gisela Di Venanzio, Clay D Jackson-Litteken, Nichollas E Scott, Mario F Feldman

2020-Current year OA Pubs

Although considered primarily extracellular,

The Inferred Functional Connectome Underlying Circadian Synchronization In The Mouse Suprachiasmatic Nucleus, K L Nikhil, Bharat Singhal, Daniel Granados-Fuentes, Jr-Shin Li, István Z Kiss, Erik D Herzog

2020-Current year OA Pubs

Circadian rhythms in mammals arise from the spatiotemporal synchronization of ~20,000 neuronal clocks in the suprachiasmatic nucleus (SCN). Although anatomical, molecular, and genetic approaches have revealed diverse SCN cell types, how network-level wiring enables their synchronization remains unclear. To overcome the challenges of inferring functional connectivity from fixed tissue, we developed Mutual Information & Transfer Entropy (MITE), an information-theoretic framework to infer directed cell-cell connections with high fidelity from long-term live-cell imaging. Recording and analyzing 3,290 h of clock gene expression from 8,261 SCN neurons across 17 mice, we uncovered a highly conserved, sparse SCN network organized into two asymmetrically …

Exploiting Large Language Models For Diagnosing Autism Associated Language Disorders And Identifying Distinct Features, Chuanbo Hu, Wenqi Li, Mindi Ruan, Xiangxu Yu, Shalaka Deshpande, Lynn K Paul, Shuo Wang, Xin Li

2020-Current year OA Pubs

Diagnosing language disorders associated with autism is a complex challenge, often hampered by the subjective nature and variability of traditional assessment methods. In this study, we explored large language models (LLMs) to overcome the speed and precision obstacles by enhancing sensitivity and profiling linguistic features for autism diagnosis. This research utilizes natural language understanding capabilities of LLMs to simplify and improve the diagnostic process, focusing on identifying autism-related language patterns. We showed that the proposed method demonstrated improvements over the baseline models, with over a 10% increase in both sensitivity and positive predictive value in a zero-shot learning configuration. Combining …

Clinical Practice Variation Among Pediatric Rheumatologists Treating Kawasaki Disease: Results Of A North American Survey, Daniel Ibanez, Bianca Lang, Julia Shalen, Ali Yalcindag, Linda Wagner-Weiner, Kenneth N Schikler, Shoghik Akoghlanian, Hulya Bukulmez, Kristen Hayward, Laura Berbert, Sivia Lapidus, Andrea A Ramirez, Cagri Yildirim-Toruner

Faculty, Staff and Students Publications

Background: The best treatment for children with KD who fail to respond to the first dose of IVIG (refractory KD) is currently unknown. The purpose of this study was to determine treatment practices of pediatric rheumatologists in North America who manage IVIG-refractory KD.

Methods: A 34-item web-based survey was sent to 102 randomly selected members of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). The anonymous survey addressed the use of primary intensification as well as the treatment of IVIG-refractory KD.

Results: The response rate was 82%; 56% (all pediatric rheumatologists) completed the survey. Primary intensification was …

Holter Monitor Qt Dispersion And Qtc-Dispersion In Pediatric Long Qt Syndrome And Development Of A Diagnostic And Arrhythmia Risk Prediction Model, Hadeel Allam, Na Le Dang, Edita Karasalihovic, Nathan Miller, Lisa Roelle, William B Orr, Dustin Nash, Anthony G Pompa, Jennifer N A Silva

2020-Current year OA Pubs

BACKGROUND: Holter monitors can provide temporal QT analysis, allowing for calculation of QT dispersion and corrected QT dispersion over time. We describe the results of the QT dispersion and corrected QT dispersion over a 24-hour period in pediatric patients with long QT syndrome (LQTS), compared with a normal cohort, and develop 2 new machine learning models for diagnosis and arrhythmia risk prediction in LQTS.

METHODS: A single-center retrospective case-control study was conducted comparing patients with congenital LQTS and normal controls who underwent a clinically indicated Holter between January 2022 and May 2024. After identifying patients with cardiac events, 2 neural …