Digital Commons Network^™

Reducing Marine Plastic Pollution: Critical Assessment Of The Potential To Develop A Civil Liability And Compensation Mechanism Under The Law Of The Sea Convention, Alexandra Leaton

School of Law, Humanities and Social Sciences Theses

Plastic pollution has had a detrimental global impact, particularly in the marine environment, due to its mobility, longevity, and tendency to be difficult to retrieve. The situation has worsened because of the increased production and consumption of plastics and the fact that pollution occurs throughout the entirety of plastics’ production and lifecycle. Its pathways/vectors to the marine environment are diffuse and complex. The combined environmental, social, and potential health impacts of plastics have resulted in the development of over 40 international legal and other regulatory mechanisms, although inconsistent implementation has resulted in a fragmented framework with gaps and overlaps. The …

Transient Lives: Trans & Non-Binary People’S Encounters With The Harms Of Work, Siggi Auerbach

School of Law, Humanities and Social Sciences Theses

This ethnographic criminological research aimed to address several theoretical gaps in the existing literature surrounding trans people, vulnerability, and victimisation. The overarching objective of this study was to offer a revised account of the harms trans people encounter in relation to their work via a new theoretical framework which is informed by ultra-realist criminology, critical hate studies. The theoretical framework was informed by contemporary criminologies of the harms of work, as opposed to the harms the institution of work is argued to inflict upon intersectional aspects of the individual’s social identity. This thesis aimed to reconceptualise the harms trans workers …

The Collecting Habits On An Eighteenth-Century Englishman Of Discernment: Charles Rogers, Frs, Fra (1711-1784), Nicola Wakeham

School of Law, Humanities and Social Sciences Theses

Abstract The Collecting Habits of an Eighteenth-Century Englishman of Discernment: Charles Rogers FRS, FSA (1711-1784) Nicola Frances WakehamThis project aims to establish the largely forgotten collector, Charles Rogers FRS FSA (1711-1784), and his collection of prints and drawings, within the vibrant cultural and intellectual milieu of the eighteenth-century art world. Structured around three interrelated strands: Rogers’ role as a connoisseur in the eighteenth-century art world, the scope and significance of the collection itself, and his contribution to early art historical writing, the study offers a multifaceted reassessment of Rogers' place in art history.The first strand explores Rogers as an knowledgeable …

What Helps And Hinders Staff Supporting People With Intellectual Disabilities Regarding Sex And Relationships, Laurence Constable, Deanna Gallichan

School of Psychology Theses

Background Studies have suggested that staff experience multiple obstacles to providing effective support around relationships and sexuality. The literature has suggested several potential solutions yet it is not clear what impedes the implementation of these. Understanding these barriers could improve care. Methods Two focus groups were carried out with a total of 13 participants recruited from the Southwest of England. Participants were recruited from client-facing roles across care providers, education provision, and social care provision. The focus groups were analysed using reflexive thematic analysis. Findings Four themes were drawn from the data. These were ‘Fear hinders care’, ‘Care is led …

Exploring Individuals’ Experiences Of Working With Probation Who Have Personality Disorder: A Community-Based Participatory Action Research Approach., Nikki Morfey

School of Psychology Theses

Utilizing a Community-Based Participatory Action Research approach, semi-structured interviews were used to explore seven individuals’ experiences of working with Probation who self-identified as screening into the Offender Personality Disorder (OPD) Pathway. Interpretative Phenomenological Analysis (IPA) of the data resulted in the construction of six Group Experiential Themes. Findings reflect participant confusion with the Personality Disorder label in light of feeling it was imposed without discussion, speaking to their experiences of the power dynamic in the probation relationship. Participants described being reduced to a case to be managed, with no space to be seen as a person, and a gap between …

‘I Am Free, But I Am Not Free’: Nature-Based Interventions With Refugee And Asylum Seekers – An Ethnographic Action Informed Study, Louise Morgan

School of Psychology Theses

Refugees and asylum seekers (RAS) in the UK face significant barriers to well-being due to hostile immigration policies and limited mental health support. Nature-based interventions (NBIs) are emerging as culturally inclusive psychosocial support, yet RAS experiences remain underexplored. An Ethnographic Action Research (EAR) informed approach was used to examine a nature-based programme in Southwest England, developed with four lived experience co-researchers. Data was collected through five observation days, sixteen conversations, and one focus group, involving three staff facilitators and 30 RAS participants. Thematic Framework Analysis identified four themes: To Access, To Connect and Belong, To Survive, and To Be Me …

Bridging The Gap: A Mixed Methods Study Of Trainee Clinical Psychologists’ Experiences And Learning Needs For Working With Refugees, With Co-Produced Training Guidelines., Megan Stuart-Richards

School of Psychology Theses

AbstractRefugees face unique and traumatising challenges to their mental health across multiple socio-political climates. Services are providing inequitable support for refugees, which lack appreciation of transcultural conceptualisations of mental distress, amongst a backdrop of social injustice. Refugees were employed as Co-researchers to co-produce every stage of this project. Reflexive Thematic Analysis was utilised in this study to examine experiences and learning needs of 79 Trainee Clinical Psychologists (TCP’s) in their survey responses. Novel training guidelines, to be accessed via ‘supplementary materials’, were co-produced alongside scoped learning needs, which contribute to health research and practice. Four interrelated overarching themes became evident. …

Impact Of Methicillin-Resistant Staphylococcus Aureus Surveillance And Decolonization In The Nicu: The Texas Children’S Hospital Experience, Krystal Purnell, Elizabeth Tocco, Tjin Koy, Kenneth Nobleza, Duc Nguyen, Lucila Marquez

Faculty, Staff and Students Publications

OBJECTIVE: To determine the impact of screening and decolonization on methicillin-resistant

STUDY DESIGN: This is a single-center retrospective cohort study comparing patient characteristics among MRSA-colonized and MRSA-infected infants, rates of MRSA infection before and after screening with targeted decolonization, and MRSA infection among those receiving single or combined decolonization agents.

SETTING: Texas Children's Hospital Pavilion for Women is a 42-bed level three neonatal intensive care units (NICU) in Houston, TX.

PATIENTS: Neonates admitted to the NICU from 2012 to 2022 were included in analysis of MRSA colonization and infection. The gestational age ranged from 22 weeks to 42 weeks.

INTERVENTIONS: …

Increasing Premedication For Neonatal Intubation: A Quality Improvement Initiative

Faculty, Staff and Students Publications

INTRODUCTION: Endotracheal intubation is frequent in the neonatal intensive care unit (NICU) but may result in neonatal distress and instability. Premedication reduces adverse effects, such as hypoxia, bradycardia, and pain. The Specific, Measurable, Achievable, Relevant and Time-Bound aim for this project was to increase premedication use for nonemergent neonatal intubation in a specific NICU from 22% to 80% from March 2021 to May 2023.

METHODS: We use quality improvement methodology to explain our theory for improvement. Our key driver diagram depicts this initiative's aims, key drivers, and interventions to increase premedication use for neonatal intubation. We defined exclusion criteria and …

Bcg-Induced Dna Methylation Changes Improve Coronavirus Disease 2019 Vaccine Immunity Without Decreasing The Risk For Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Marisa Lozano, Seth P Lerner, Rebecca Hannigan, Tomoki Nishiguchi, Abhimanyu, Daanish Sheikh, Malik Ladki, Alexandra Portillo, Amrit Koirala, Tajhal D Patel, Zoe Spieler, Aaron B Benjamin, Maxim Lebedev, Theresa U Ofili, Robert W Hutchison, George Udeani, Lynne A Opperman, Gabriel Neal, Anna M Mandalakas, Mihai G Netea, Moshe Arditi, Pablo Avalos, Sandra L Grimm, Cristian Coarfa, Jeffrey D Cirillo, Andrew R Dinardo

Faculty, Staff and Students Publications

BACKGROUND: The BCG vaccine induces trained immunity, an epigenetic-mediated increase in innate immune responsiveness. Therefore, this clinical trial evaluated if BCG-induced trained immunity could decrease coronavirus disease 2019 (COVID-19)-related frequency or severity.

METHODS: A double-blind, placebo-controlled clinical trial of healthcare workers randomized participants to vaccination with BCG TICE or placebo (saline). Enrollment included 529 healthcare workers randomized to receive BCG or placebo. Primary analysis evaluated COVID-19 disease frequency, while secondary analysis evaluated coronavirus immunity in a subset of participants. Study enrollment ceased early in December 2020 following introduction of COVID-19-specific vaccines.

RESULTS: Study enrollment was halted early, prior to reaching …

Predictive Equation Derived From 6,497 Doubly Labelled Water Measurements Enables The Detection Of Erroneous Self-Reported Energy Intake, Zongfang Liu, Yosuke Yamada, Heliodoro Aleman-Mateo, Liam J Anderson, Lenore Arab, Issad Baddou, Linda Bandini, Kweku Bedu-Addo, Ellen E Blaak, Carlijn V C Bouten, Soren Brage, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Regina Casper, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Peter S W Davies, Prasangi Dabare, Lara R Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Melanie Gillingham, Annelies H Goris, Michael Gurven, Asmaa El Hamdouchi, Hinke H Haisma, Daniel Hoffman, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Misaka Kimura, William E Kraus, Wantanee Kriengsinyos, Rebecca Kuriyan, Robert F Kushner, Estelle V Lambert, Pulani Lanerolle, Christel L Larsson, William R Leonard, Nader Lessan, Marie Löf, Corby K Martin, Eric Matsiko, Anine C Medin, James C Morehen, James P Morton, Aviva Must, Marian L Neuhouser, Theresa A Nicklas, Christine D Nyström, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Susan B Racette, David A Raichlen, Eric Ravussin, Leanne M Redman, John J Reilly, Rebecca Reynolds, Susan B Roberts, Dulani Samaranayakem, Luis B Sardinha, Analiza M Silva, Anders M Sjödin, Marina Stamatiou, Eric Stice, Samuel S Urlacher, Ludo M Van Etten, Edgar G A H Van Mil, George Wilson, Jack A Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Srishti Sinha, Cornelia U Loechl, Amy H Luke, Herman Pontzer, Jennifer Rood, Hiroyuki Sagayama, Dale A Schoeller, Klaas R Westerterp, William W Wong, John R Speakman

Faculty, Staff and Students Publications

Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes with the total energy expenditure (TEE). In this study, we used the International Atomic Energy Agency Doubly Labeled Water Database to derive a predictive equation for TEE using 6,497 measures of TEE in individuals aged 4 to 96 years. The resultant regression equation predicts expected TEE from easily acquired variables, such as body weight, age and sex, with 95% predictive limits that can be used …

Proteomic Characterization And Comparison Of The Infective And Adult Life Stage Secretomes From Necator Americanus And Ancylostoma Ceylanicum, Mali Camberis, Graham Legros, Bin Zhan, Maria Elena Bottazzi, Ricardo T Fujiwara, Edita Ritmejeryte, Thewarach Laha, Sujittra Chaiyadet, Piyanan Taweethavonsawat, Paul J Brindley, Bethany K Bracken, Paul R Giacomin, Makedonka Mitreva, Alex Loukas

Faculty, Staff and Students Publications

More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management approaches are limited by modest drug efficacy, the costs associated with frequent mass drug administration campaigns, and the risk of reinfection and burgeoning drug resistance. Subunit vaccines based on proteins excreted and secreted (ES) by hookworms that reduce worm numbers and associated disease burden are a promising management strategy to overcome these limitations. However, studies on the ES proteomes of hookworms have mainly described proteins from the adult life stage …

Aerodigestive Sequelae And Triple Endoscopy After Congenital Tracheoesophageal Fistula Repair In Children, Kathleen E Hosek, Elton M Lambert

Faculty, Staff and Students Publications

Children post-tracheoesophageal fistula (TEF) repair may present with chronic respiratory and gastrointestinal symptoms that can affect quality of life.

OBJECTIVE: To identify factors associated with positive findings on triple endoscopy following neonatal TEF repair.

STUDY DESIGN: Case series with retrospective review of patients.

SETTING: Tertiary care center aerodigestive program.

METHODS: Children with neonatally repaired congenital TEF who had a triple endoscopy between 2011 and 2022 were reviewed. The presence of chronic cough, recurrent pulmonary infections, lipid-laden macrophages (LLM), and airway and esophageal anomalies were among the variables analyzed. Chi-square and Kruskal-Wallis univariate analysis was performed.

RESULTS: The mean age was …

Altering The Intracellular Trafficking Of Necator Americanus Gst-1 Antigen Yields Novel Hookworm Mrna Vaccine Candidates, Rakesh Adhikari, Maria Jose Villar, Jeanna R Redd, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet

Faculty, Staff and Students Publications

BACKGROUND: The antigen Na-GST-1, expressed by the hookworm Necator americanus, plays crucial biochemical roles in parasite survival. This study explores the development of mRNA vaccine candidates based on Na-GST-1, building on the success of recombinant Na-GST-1 (rNa-GST-1) protein, currently assessed as a subunit vaccine candidate, which has shown promise in preclinical and clinical studies.

METHODOLOGY/FINDINGS: By leveraging the flexible design of RNA vaccines and protein intracellular trafficking signal sequences, we developed three variants of Na-GST-1 as native (cytosolic), secretory, and plasma membrane-anchored (PM) antigens. After one immunization in mice, mRNA vaccines induced an earlier onset of antigen-specific antibodies compared to …

Impact Of Antiparasitic Therapy On Cardiovascular Outcomes In Chronic Chagas Disease A Systematic Review And Meta-Analysis, Ranjit Sah, Sangam Shah, Nelson I Agudelo Higuita, Fabio Mahamed Rassi, Michaele Francesco Corbisiero, Hannah M Kyllo, Jordan Stellern, Samantha Kaplan, Luis A Marcos, Edgar A Ramírez-García, Martin Casapia, Peter Hotez, Maria Elena Bottazzi, Shital Patel, Carlos Franco-Paredes, José Antonio Marin-Neto, Andrés F Henao-Martínez

Faculty, Staff and Students Publications

BACKGROUND: Endemic in more than 20 countries, Chagas disease affects 6.3 million people worldwide, leading to 28,000 new infections and 7700 deaths each year. Previous meta-analyses on antiparasitic treatment need updates to encompass recent studies and to assess key clinically meaningful endpoints. This study aims to evaluate the impact of antitrypanosomal therapy in preventing or reducing disease progression and mortality in chronic Chagas disease.

METHODS: We performed a systematic review and meta-analysis of studies reporting the cardiovascular outcomes of antitrypanosomal therapy in patients with chronic Chagas disease. We searched Ovid Embase, Ovid MEDLINE, Ovid Global Health, Scopus, Web of Science …

Anti-Racist And Anti-Colonial Content Within Us Global Health Curricula, James C Hudspeth, Bethany Hodge, Marideth Rus, Heather Haq

Faculty, Staff and Students Publications

There is a growing interest to address pervasive racist and colonialist practices in global health (GH). However, there is a paucity of information on anti-racist and anti-colonial (ARAC) education for GH trainees. This study aimed to identify curricular strengths and gaps in ARAC content for pediatric, family medicine and emergency medicine trainees participating in GH. We conducted a cross-sectional survey of GH programs' ARAC curricular content from May 2021 to January 2022. The survey was distributed to 148 GH program educational leaders via email. Descriptive statistics were used to describe quantitative data and comments were reviewed for common themes. The …

Exploring Implementation Strategies In Evidence-Based Open Streets Programs For Promoting Physical Activity In The Americas: A Scoping Review, Raúl D Gierbolini-Rivera, Milena Franco Silva, Lorna Fabiola Pineda, Bryan J Weiner, Byron J Powell, Ross C Brownson, Diana C Parra

2020-Current year OA Pubs

INTRODUCTION: Chronic diseases are a leading public health concern in the Americas, and physical inactivity contributes significantly to their burden. Open streets program-community initiatives that temporarily close urban streets to vehicles-promote physical activity and community engagement, demonstrating positive health and social impacts. Effective implementation depends on identifying suitable strategies and frameworks. The Expert Recommendations for Implementing Change (ERIC) taxonomy, developed for clinical/healthcare contexts, has not been widely assessed for community-based interventions such as Open Streets. Implementation strategies could lead to specific outcomes (e.g., adoption, sustainability) that differ from program outcomes (e.g., PA levels, chronic disease prevalence). This scoping review focuses …

Caregiver Determinants And Capacity For Participation In Constraint-Induced Movement Therapy, Hunter G Moore, Amy Ayala, Bhooma R Aravamuthan, Alyssa E Smith, Sharon L Ramey, Catherine R Hoyt

2020-Current year OA Pubs

AIM: Hemiplegic cerebral palsy affects 1 in every 1,100 children, making it the most common pediatric motor disability. Constraint-Induced Movement Therapy (CIMT) is an evidence-based intervention that significantly improves upper extremity function when implemented with high fidelity. Despite its effectiveness, CIMT's intensive nature-requiring daily therapy for up to twenty days-limits its availability. This study examined caregivers' perspectives on implementing and adapting home-based CIMT to identify practical solutions for improving intervention accessibility.

METHOD: Caregivers of a child who has a diagnosis associated with upper extremity motor impairment consistent with cerebral palsy were recruited from the Cerebral Palsy Center at the St. …

Adaptation Of A Digital Health Intervention For Rural Adults: Application Of The Framework For Reporting Adaptations And Modifications-Enhanced, Maura M Kepper, Callie Walsh-Bailey, Loni Parrish, Ainsley Mackenzie, Lisa M Klesges, Peg Allen, Kia L Davis, Randi Foraker, Ross C Brownson

2020-Current year OA Pubs

INTRODUCTION: Adaptation is a key aspect of implementation science; interventions frequently need adaptation to better fit their delivery contexts and intended users and recipients. As digital health interventions are rapidly developed and expanded, it is important to understand how such interventions are modified. This paper details the process of engaging end-users in adapting the PREVENT digital health intervention for rural adults and systematically reporting adaptations using the Framework for Reporting Adaptations and Modifications-Enhanced (FRAME). The secondary objective was to tailor FRAME for digital health interventions and to document potential implications for equity.

METHODS: PREVENT's adaptations were informed by two pilot …

Developing And Testing Tele-Support Psychotherapy Using Mobile Phones For Depression Among Youth In Kampala District, Uganda: Study Protocol For A Pilot Randomized Controlled Trial, Etheldreda Nakimuli-Mpungu, Jeremiah Mutinye Kwesiga, John Mark Bwanika, Davis Musinguzi, Caroline Nakanyike, Jane Iya, Sabrina Bakeera Kitaka, Benedict Akimana, Charlotte Hawkins, Patricia Cavazos, Jean B Nachega, Edward J Mills, Musisi Seggane

2020-Current year OA Pubs

INTRODUCTION: In the post-COVID-19 era, depressive disorders among youth have risen significantly, creating an urgent need for accessible, cost-effective mental health interventions. This study adapts Group Support Psychotherapy into Tele-Support Psychotherapy (TSP) via mobile phones. It aims to evaluate its feasibility, acceptability, effectiveness, and cost-efficiency in addressing mild to moderate depression among youth in central Uganda.

METHODS AND ANALYSIS: This study will use a mixed-methods approach, starting with a qualitative phase to adapt Group Support Psychotherapy into Tele-Support Psychotherapy (TSP) via mobile phones. Guided by ecological theories and the Unified Theory of Acceptance and Use of Technology (UTAUT), focus group …

Advancing Sustainability In Low-Resource Settings: Development And Validation Of A Sustainability Tool For Evidence-Based Interventions And Programs, Chisom Obiezu-Umeh, Divya S Subramaniam, Ucheoma Nwaozuru, Titilola Gbaja-Biamila, Lateef Akeem Blessing, Thembekile Shato, David Oladele, Lisa R Hirschhorn, Enbal Shacham, Hong Xian, Oliver Chukwujekwu Ezechi, Juliet Iwelunmor

2020-Current year OA Pubs

INTRODUCTION: Despite substantial research and growing evidence on effectiveness, the longer-term benefits of proven healthcare interventions and programs have not been fully explored due to challenges sustaining such efforts. Existing sustainability measures developed in high-income countries may not reflect determinants unique to the sustainability of interventions in low- and middle-income countries (LMICs), including African countries. To address this gap, our study developed a Sustainability Tool to Assess Evidence-Based Interventions and Programs (STEPS), which provides a theory-based measure that can be used to assess multilevel determinants of sustainability from the perspective of frontline health workers, service providers, or implementation practitioners.

METHODS: …

Applications Of Quantum Computing In Clinical Care, Stevan C Fairburn, Lara Jehi, Brenton T Bicknell, Beckley G Wilkes, Bharat Panuganti

2020-Current year OA Pubs

INTRODUCTION: This review examines quantum computing (QC) applications in clinical care, emphasizing advancements directly impacting patient outcomes. QC holds transformative potential in medicine, particularly through enhancing diagnostic accuracy, optimizing treatment plans, and enabling real-time decision-making.

METHODS: A systematic analysis of 35 studies published between 2015 and 2024 was conducted. The studies were evaluated for their contributions to diagnostic, therapeutic, and decision-support improvements in clinical care enabled by quantum computing technologies.

RESULTS: The analysis revealed QC's promise in improving diagnostic accuracy in medical imaging, optimizing treatments in oncology, and enhancing real-time clinical decision-making. QC-driven algorithms demonstrated potential to enhance diagnostic accuracy …

The Catalytic Tool To Assess Feasibility Of Implementing Evidence-Based Interventions For Cardiovascular Diseases In 46 Low- And Middle-Income Countries: Survey Outcomes And Tool Reliability Testing, Temitope Ojo, Hanan Yassin, Esther Sowunmi, Tania Hameed, Nessa Ryan, Joyce Gyamfi, Donna Shelley, Olugbenga Ogedegbe, Emmanuel Peprah

2020-Current year OA Pubs

BACKGROUND: Evidence-based interventions (EBI) for cardiovascular disease (CVD) in low- and middle-income countries (LMIC) may face feasibility challenges due to the inadequacy of existing instruments. To address this, researchers developed the Contextual Index of Feasibility on Early-Stage Implementation in LMIC (CATALYTIC) tool, which integrates contextual factors into the assessment of feasibility.

METHODS: The tool's items were developed through a systematic review and key informant interviews, and were later assessed for relevance and importance by 13 LMIC researchers and implementers employing a Delphi technique. The survey was then tested for usability by five individuals with CVD experience in LMIC. The CATALYTIC …

Religious Factors Predict Support For Genomic Medicine More Strongly Than Politics, Education, Or Trust: A Survey Of 4,939 Adults In The United States, James M Dubois, Eu Gene Chin, Erin D Solomon, Jenine K Harris, Peter Hill, Kari Baldwin, Lauren L Baker

2020-Current year OA Pubs

BACKGROUND: Religious affiliation and attendance at services is associated with lower levels of support for some genomic activities, such as genetic testing. However, little is known about why or how religion shapes attitudes toward genomics.

MATERIALS AND METHODS: We conducted a cross-sectional survey with 4,939 participants representative of nine religious groups in the US (including atheist and agnostic). The survey examined (a) attitudes toward diverse activities associated with genomic medicine, (b) religious beliefs and practices, (c) control variables including trust in the healthcare system and knowledge of genetics, and (d) demographics. We examined differences between groups using an Analysis of …

Dual Inhibitor Of Mdm2 And Nfat1 For Experimental Therapy Of Breast Cancer: In Vitro And In Vivo Anticancer Activities And Newly Discovered Effects On Cancer Metabolic Pathways, Abigail Alley, Meheret Tadesse, Xinshi Wang, Xia Gao, Ruiwen Zhang

Faculty, Staff and Students Publications

INTRODUCTION: The oncogene MDM2 has garnered attention not only for its role in cancer as a negative regulator of the tumor suppressor p53 but also for its p53-independent oncogenic activities. MDM2 also involves metabolic reprogramming, such as serine metabolism, respiration, mitochondrial functions, the folate cycle, and redox balance. Traditional MDM2 inhibitors blocking the protein-protein binding between MDM2 and p53 have shown limited clinical success in various stages of clinical trials, most likely due to low efficacy, drug toxicity, and drug resistance, highlighting the need for a novel, p53-independent strategy to inhibit MDM2. The present study investigated the antitumor effects of …

From Theory To Practice: Simulating Zero Trust Architecture With Python For Cybersecurity, Pankaj R. Chandre, Bhagyashree D. Shendkar, Sulochana Sagar Madachane, Nikita Kulkarni, Sayalee Deshmukh

ASEAN Journal on Science and Technology for Development

The increasing complexity and frequency of cyber threats have necessitated the adoption of advanced security models, such as Zero Trust Architecture (ZTA). ZTA runs on the tenet that no entity whether inside or outside the network should be trusted by default, in contrast to conventional perimeter-based security solutions. This paper describes a thorough method for simulating and implementing Zero Trust Architecture in Python. We examine the essential elements and procedures of ZTA, such as identity verification, access control, and continuous monitoring, through a thorough analysis and step-by-step manual. The simulation shows how ZTA works to ensure strong network security and …

Unwritten Rules And Oral Transmission In Architectural Proportion Systems: Case Study Of Bubungan Tinggi House, Huzairin. Muhammad Deddy, Dila Nadya Andini, Rudi Hartono, Anna Oktaviana, Dahliani Dahliani

ASEAN Journal on Science and Technology for Development

The proportional systems in vernacular architecture often exist without formal written codification, raising questions about their transmission across generations. Bubungan Tinggi House which is a replica of the Banjar Kingdom palace was built by Banjarese merchants and aristocrats from the 16th to the 19th centuries, showing a uniform aesthetic quality, which indicates a regularity in the proportions of its form. However, no historical written manuals detailing these proportions are known to exist. To prove the existence of regularity in the Bubungan Tinggi House proportion system, research was conducted by taking 7 Bubungan Tinggi House samples spread across South Kalimantan province, …

Editorial: A Decade Of Apasti – Advancing Regional Prosperity Through Science, Technology And Innovation, Basilios Tsikouras

ASEAN Journal on Science and Technology for Development

A decade after its establishment, APASTI has emerged as a key regional mechanism for promoting science, technology and innovation as drivers of sustainable development, resilience, and shared prosperity in Southeast Asia. This editorial highlights the contributions of APASTI to policy alignment, knowledge exchange, research visibility, and collaborative network-building across ASEAN, while also acknowledging ongoing constraints related to governance, capacity, funding disparities, and uneven regional integration. It introduces a special issue of 14 papers published in AJSTD that collectively evaluate the implementation and impact of APASTI across diverse sectors, including geohazards, energy, materials, health, infrastructure, transport, and information systems. By positioning …

Performance Evaluation And Economic Analysis Of Lithium Iron Phosphate (Lfp) And Nickel Manganese Cobalt (Nmc) Batteries In Electric Vehicles In Indonesia, Yasa Sanusi, Fatwa Tresna Radityan, Farrah Anis Fazliatul Adnan, Jong Soo Rhee, Dianta Ginting

ASEAN Journal on Science and Technology for Development

The transfer to electric vehicles (EVs) in more and more countries is a response to the increasing problems of climate change and air pollution. Electric cars solve this issue as they have zero emissions. EVs can significantly reduce carbon and air pollution, depending on the charging energy mix. In Indonesia, lithium ferro phosphate and nickel manganese cobalt are among the two most preferred types of batteries for EVs, and both have their advantages. This study evaluates the performance of these batteries in terms of power, range, charging speed, and thermal properties, using a range of battery capacities from 26.7 kWh …

Barriers Principals Face Integrating Blended Learning In Secondary Schools, Lacey Tremaine Ajibola

Electronic Theses and Dissertations

The purpose of this qualitative case study was to explore the barriers secondary principals encounter integrating instructional technology as a part of a blended learning model. Existing research investigating the barriers principals face is limited and fractured and is mostly examined from the perspective of teachers. Therefore, this study provided data on the perspective and experiences of principals as technology leaders and their perceived barriers to implementing blended learning models. The researcher aligned the research questions to the International Society for Technology in Education Standard for Educational Leaders as a conceptual framework. Interviews with 11 secondary principals from the same …