Digital Commons Network^™

Investigating Rna Dysfunction Of Inherited Neuromuscular And Neurodevelopmental Disease, Jacob H. Schroader

Electronic Theses & Dissertations (2024 - present)

ITPase deficiency is a rare but fatal, autosomal recessive enzyme deficiency involving encephalopathy, microcephaly, congenital cataracts, hypotonia, developmental delay, and dilated cardiomyopathy. Within a decade since the original description of the severe form in humans, there are huge gaps in the field regarding the underlying molecular mechanisms driving pathogenesis resulting from ITPase deficiency. Past studies have focused on characterization of the organism level ITPase-deficient phenotype, but the molecular and cellular characterization remains to be fully described. Due to the biochemical function and established biological role of the ITPase enzyme, investigation into the consequences of inosine accumulation and misincorporation into RNA …

Photoswitchable Inhibitors Of Eaat3, Karly Suhr

Electronic Theses & Dissertations (2024 - present)

Azobenzene is a photoswitchable molecule known for its high conversion yield and repeatability. The inclusion of an azobenzene moiety with a known inhibitor of your target of interest allows for greater study of function as well as potential therapies. Three derivatives were designed from azobenzene and known inhibitor of EAATs, TBOA, to synthesize photoswitchable inhibitors of EAATs. Further investigation into the function of EAATs and development of a specific inhibitor for EAAT3, an important glutamate transporter in the brain required for proper function, can then be conducted. Photoisomerization studies on the derivatives were conducted using UV/vis spectroscopy and NMR spectroscopy. …

Investigating The Perceived Masculinity And Femininity Of Nonbinary Individuals, Dante D. Sasso Jr.

Electronic Theses & Dissertations (2024 - present)

Nonbinary individuals identify outside of the typical gender binary of men and women. Existing research has not investigated how nonbinary people are perceived in terms of masculinity and femininity. We hypothesized that nonbinary individuals would be perceived as less masculine than men and less feminine than women, while also being perceived as overall more feminine than masculine. Participants viewed a researcher-generated social media profile. The primary experimental manipulation involved varying the pronouns listed in the profile biography, denoting a man (he/him), woman (she/her), or nonbinary person (they/them). Participants rated how masculine and feminine they perceived the target person to be, …

Differences In Mental Health Care Use Between Urban And Rural Populations In New York State, 2017-2022, Anna J. Papa

Electronic Theses & Dissertations (2024 - present)

Objective

This study aimed to determine whether rural New York State residents receive mental health care at the same rate as urban residents, how poverty rates in New York State relate to rurality and mental health care use, and how pre-pandemic mental health care use rates compare to 2022 use rates. The goal was not to estimate the burden of disease, nor to estimate the number of patients engaged in care in each zip code, but to highlight the potential differences in service use between urban and rural New York State Office of Mental Health clients.

Methods

A secondary analysis …

Rethinking Rural Identity: Reimagining Rural Politics, Matthew B. Kirk

Electronic Theses & Dissertations (2024 - present)

This work chiefly consists of a genealogical critique of rural identity. Tracing the development and deployment of the concepts of rurality and rural consciousness, I argue that our current depictions of rurality as “spatial other,” replete with its harmful stereotypes, stem from a misconception about the nature of power. Political theorists’ and political scientists’ appraisals of rurality suggest that the set of actions that define rural politics are a product of their relative powerlessness. Rural locales’ removal from the center of power in urban spheres means that rural politics is reduced to reactionary, violent, and conservative political thought and engagement. …

Essays On Technological Change And Scientific Research, Max Mayca

Electronic Theses & Dissertations (2024 - present)

The primary objective of economic science has long been to understand and promote growth, as it contributes to a more prosperous civilization and improves individual well-being. The core drivers of growth—capital accumulation, human capital development, and technological progress—are well-established. While capital deepening enables scaling of production, and human capital enhances labor productivity, technological and scientific advancements remain the most critical, as they continually redefine the efficiency frontier. Given this centrality, it is essential to understand how technological progress affects labor markets, how research resources should be allocated, and how technology relates to human capital formation.

The first part of this …

Stress And Resilience In Higher Education Administrators: Exploring The Role Of Mindfulness, Michael Baumgardner

Electronic Theses & Dissertations (2024 - present)

This dissertation explores stressors experienced by higher education administrators (HEAs) and examines the role of mindfulness practices in mitigating stress and fostering resilience and job satisfaction. HEAs manage essential institutional functions yet face intensifying pressures from volatile funding streams, shifting demographics, changing public perceptions, political and cultural challenges, technological disruptions, and pandemic-related change. Despite HEAs central role in sustaining higher education, limited research examines how these professionals experience stress, and even less has considered mindfulness as a potential resource for coping and resilience.

Guided by a qualitative methodological approach, this study draws on semi-structured, thick description interviews with 18 HEAs …

Essays On Health Economics, Yiran Han

Electronic Theses & Dissertations (2024 - present)

The first chapter examines relationships between physicians exposed to new drugs’ clinical trials and prescribing. Clinical trials benefit patients directly by providing novel treatments, but little is known about the indirect effects of clinical trials on physician prescribing through localized knowledge spillover. This study examines whether exposure to a clinical trial of a new drug in a physician’s local geographic area affects the physician’s propensity to prescribe the drug, i.e. a localized knowledge spillover from clinical trial sites to physician. Utilizing the Medicare Part D prescribing patterns of more than 10,000 physicians across 29 new cancer drugs approved by the …

Backgrounds And Efficiencies For Low-Energy Searches, And Improved Calibration Techniques In The Lux-Zeplin Dark Matter Experiment, Gregory M. Blockinger

Electronic Theses & Dissertations (2024 - present)

The full understanding of dark matter has eluded physicists for many years. While there is abundant astrophysical evidence across many scales, the exact nature of this matter, which comprises about 25% of the Universe’s energy density, remains unknown. Weakly Interacting Massive Particles (WIMPs) are one of the leading theoretical candidates, and numerous ex- periments have searched for their interactions. In recent decades, dual-phase Time Projection Chambers (TPCs) have become the leading technology in this search. The LUX-ZEPLIN (LZ) detector is one such xenon-based experiment, operating nearly a mile underground in the Black Hills of South Dakota at the Sanford Underground …

Y’All Means All: Pro-Choice Abortion Activism In West Texas Post-Dobbs, Hannah S. Noblewolf

Electronic Theses & Dissertations (2024 - present)

In the spring of 2021, a six-week abortion ban passed by popular vote in the city of Westerburg, Texas. It had a civil enforcement mechanism, allowing someone to collect a reward of $2,000 if they successfully sued someone they reported for “aiding and abetting” abortion. The ban, called the Westerburg Sanctuary City ordinance, was referred to as “bounty hunting.” When the ban passed it became the template for the state-level Texas Heartbeat Act, which provides a greater financial reward for a successful civil suit, with a minimum of $10,000 plus legal fees. In the face of this ban, pro-choice activists …

How Do Young Adults With Drug Use Disorder (Dud) Utilize Treatment? Exploring And Examining Lived Experiences Towards Treatment Completion In Indonesia, Dewi Kartikawatiningsih

Electronic Theses & Dissertations (2024 - present)

In Indonesia which has the highest rate of drug addiction in Southeast Asia, there is currently little knowledge about how young adults perceive the barriers faced when completing treatment or how treatment providers' perspectives influence their treatment completion. Understanding and identifying barriers to treatment completion is essential to making drug treatment more effective. The purpose of this study is to explore the perspectives and live experiences of young adults with DUD and their addiction counselors to develop a deeper understanding of treatment needs. This study interviewed 33 clients and 15 counselors from the rehabilitation center of the Badan Nasional Narkotika …

Boundary Conditions, Symmetries, And Bootstrap In 2d Conformal Field Theory, Yucong Cai

Electronic Theses & Dissertations (2024 - present)

This dissertation contains two parts of study on the Friedan states and on the conformal bootstrap with symmetries.

The Friedan states are potential physical boundary states of the free boson. However, they exhibited a continuous spectrum in the open string sector, in contrast to more standard examples. The explicit expressions for the density of states of the Friedan states is obtained. Some pathologies and possible contradictions of these states are explored. The $g$ functions of the Friedan states are shown to be infinite, suggesting an infinite number of degrees of freedom in the theory.

The modular conformal bootstrap using the …

Nola 2150, Kristopher Ferber

Electronic Theses & Dissertations (2024 - present)

Abstract

Speculative fiction often takes a dystopic approach where authors envision what will be lost from books being banned in Fahrenheit 451 to us losing our civil liberties in 1984 to most of humanity being wiped out by an engineered virus in Oryx and Crake. This creative thesis takes a more optimistic approach by the act of preservation. In this case the city of New Orleans thriving as an underwater city protected by a glass dome in the year 2150. The city’s vibrant culture remains the same despite being almost too close to comfort to marine life. This work …

Identification Of Fentanyl And Fentanyl Analogs Found In Human Urine Using Gas Chromatography-Mass Spectrometry, Adam M. Fisher

Electronic Theses & Dissertations (2024 - present)

Identification of fentanyl and its analogs in unknown samples is a frequent practice completed in forensic crime labs, as the fentanyl epidemic continues. With the continued increase in illicit drug use, crime labs are not able to keep up with the flooding of new fentanyl analogs being developed, resulting in new analogs slipping past the crime labs’ authority. This research is to start to develop a database of commonly found fentanyl analogs in New York State. Gas Chromatography-Mass Spectrometry (GC-MS) is a widely used method for the detection and identification of illicit drugs in forensic crime labs. A database that …

Pitch Identification In Musical Dyads That Vary In Harmonic Quality And Pitch Register, Edward E. Smith

Electronic Theses & Dissertations (2024 - present)

Seror and Neill (2015) found that consonant dyads are processed more fluently than dissonant dyads. Their finding suggested that this advantage in fluency accounts for the generalized preference for these chords. Recently, Eerola and Lahdelma (2021) found that the pitch register of the chord also affects consonance judgements of musical chords. This may suggest that chords in higher registers are processed less fluently than chords in the middle register. The present study combines these two studies by investigating processing fluency for musical dyads that vary in harmonic quality and pitch register. Participants were tasked with identifying whether an initially presented …

Improving Generalizability In Image Manipulation Detection, Zhenfei Zhang

Electronic Theses & Dissertations (2024 - present)

Image manipulation detection (IMD) aims to determine whether an image has been tampered with and to identify the manipulated regions. These capabilities have become increasingly important with the rapid advancement of media editing and generation technologies, such as Photoshop and generative AI methods, which underscore the need for robust tools for media authentication. Although current state-of-the-art (SoTA) methods achieve strong results on common manipulation types, such as splicing, copy-move, and removal, they often struggle to generalize to manipulation types not represented in the training data. Consequently, their real-world applicability remains limited, with performance degrading significantly in practical scenarios.

In this …

Theoretical Foundations And Applied Performance Of Periodicity-Aware Imputation: Variable Bandpass Block Bootstrap Methods For Incomplete Time Series, Asmaa Ahmad

Electronic Theses & Dissertations (2024 - present)

Time series data are prevalent across a wide range of disciplines, including health surveillance, public policy, and environmental monitoring. In the presence of underlying cyclical patterns, the integrity of time series analysis depends critically on the ability to detect, model, and impute structured missing data without compromising the temporal structure. This dissertation introduces and validates a novel imputation framework that integrates the Variable Bandpass Periodic Block Bootstrap (VBPBB) into multiple imputation procedures, improving the accuracy, robustness, and interpretability of time series models under high rates of missingness and noise. The overarching goal of this dissertation was to develop and evaluate …

Officers’ Perceptions Of Body-Worn Cameras: An Exploratory Study Of Small Police Departments In Upstate New York, Stefan A. Dela Riva

Electronic Theses & Dissertations (2024 - present)

The aim of this exploratory study is to examine how police officers perceive the impact of body-worn cameras (BWCs) on their use of discretion when communicating with members of the public. In this context, “discretion” refers to an officer’s authority to make independent judgments while enforcing the law; deciding whether to issue a warning, make an arrest, or resolve an incident informally when legality permits. To understand officers’ opinions, a cross-sectional, quantitative online survey was distributed to various police departments and sheriff’s offices in upstate New York. Participants completed a series of Likert-style survey items addressing their general views on …

Interfacing Neural Models: Biocompatibility And Fabrication Of A Flexible, Self-Folding Microelectrode Array, Fernando A. Pesantez Torres

Electronic Theses & Dissertations (2024 - present)

Neurodegenerative diseases pose a formidable challenge in modern medicine, necessitating the development of advanced research tools that can elucidate their complex pathophysiology. Recent advancements in neurodegenerative disease research have led to the development of three-dimensional (3D) neurodegenerative organoids using human induced pluripotent stem cells (hiPSCs). These organoids closely mimic human brain architecture and functionality, providing a valuable tool for understanding complex diseases. Additionally, the ability to generate and study brain organoids consistently and in large quantities holds potential for a controlled in vitro setting and high-throughput drug screening. However, these models are complex systems requiring specialized maintenance, analysis, and manipulation …

Explaining Mass Shooting Motivations: A Case Survey Analysis Of Us Mass Shootings (2006-2024), Isaiah H. Harris

Electronic Theses & Dissertations (2024 - present)

Research on the motivations behind mass shootings remains inconclusive as these events often lack a singular or explicit cause. The motivations of mass shooters are complex, shaped by the interplay of psychological, social, and ideological factors. While some attacks are clearly driven by extremist beliefs, others appear to stem from less defined forces such as depravity or sadistic intent. Existing typologies, such as Langman’s (2009) analysis of school shooters, offer valuable insight but are limited in scope. This study expands upon previous research by examining U.S. mass shootings from 2006 to 2024 to determine whether such events are more frequently …

Welfare States And Imprisonment Rates: Revisiting The Study Of Public Assistance And Punishment In The United States, Stefan Ivanov

Electronic Theses & Dissertations (2024 - present)

In the past fifty years, the United States has seen significant changes in both the criminal legal system and the welfare state. The incarceration rate surged by 475% from 1972 to 2007, driven by state-level decisions about criminal legal policy and disproportionately affecting Black Americans. Simultaneously, welfare programs became less generous, especially for those deemed “undeserving.” A long line of social science scholarship emphasizes that these two major social institutions—the welfare state and the carceral state—must be considered as complementary and alternative methods of managing marginalized groups. Quantitative research often confirms these claims, finding a durable inverse relationship between welfare …

Pathways To Disclosure And Treatment Among Individuals With An Attraction To Minors, Theodore Jackson

Electronic Theses & Dissertations (2024 - present)

Child sexual abuse prevention is a significant social concern in the United States and internationally. While there have been some successful efforts to reduce recidivism risk among individuals who have committed sexual offenses, we fall short when preventing first time offenses. Therefore, looking at ways to provide treatment to those who are more at-risk for a first offense seems like a potential solution to this problem. One such relevant risk-factor is attraction to minors. This study is a qualitative examination using Interpretive Phenomenological Analysis of how people who are attracted to minors make the decision to disclose their attraction, seek …

A Social Exchange Perspective On Attentiveness As A Resource In Newcomer Relationship Development And Assimilation, Huy Q. Le

Electronic Theses & Dissertations (2024 - present)

My dissertation investigates the role of social relationships in newcomer socialization within organizations, emphasizing the importance of extra-role conversations in building affective trust and facilitating integration. I hypothesize that while attention to work-related tasks is crucial, engaging in extra-role conversations with supervisors and co-workers fosters affective trust, a key factor in socialization. I integrate social exchange theory, proposing that attention acts as a socioemotional resource exchanged in social interactions, leading to stronger affective trust and ultimately socialization outcomes. These informal interactions help newcomers adopt organizational values and integrate into social groups. I test my hypotheses using longitudinal archival data collected …

Buoy-Based Eddy Covariance Drag Coefficient At A Near-Shore And Offshore Site, David P. Marcial

Electronic Theses & Dissertations (2024 - present)

An eddy covariance (EC) flux system was integrated onto a Navy Oceanographic Meteorological Automatic Device (NOMAD) floating lidar buoy fitted for measuring the offshore wind resource. The EC flux system consisted of two sonic anemometers and an inertial measurement unit that together provided high-frequency (10 Hz) motion-corrected wind measurements. To assess possible impacts of flow distortion, EC momentum fluxes (10 min) were calculated in gravity-aligned, natural, and planar fit (PF) coordinate frames. The buoy was anchored near the Martha’s Vineyard Coastal Observatory Air-Sea Interaction Tower (ASIT; near-shore) for validation of the buoy-based EC fluxes against the fixed tower measurements before …

Can Financial Inclusion-Based Interventions For Poverty Alleviation Build Sustainable Livelihoods? Voices From Mutual Solidarity Groups (Muso) In Haiti., Meera R. Bhat

Electronic Theses & Dissertations (2024 - present)

Scholars, policymakers, changemakers, and social workers have attempted to define, understand, and eradicate poverty. Its endurance raises the prospect that these efforts may be incomplete or faulty. This thesis will probe this concern by examining poverty and poverty alleviation programs through the lens of a holistic intervention-based framework known as the Sustainable Livelihoods Framework (SLF). The first paper introduces the SLF and uses it to undertake a conceptual analysis comparing demand and supply driven poverty alleviation interventions that are based on financial inclusion. Next it uses the SLF as a methodological tool to compare financial inclusion programs, as operationalized by …

Advancing 4h-Silicon Carbide Power Mosfets Through Three-Dimensional Technology Computer Aided Design Optimization, Skylar A. Deboer

Electronic Theses & Dissertations (2024 - present)

This research contributes to the advancement of 1.2 kV 4H-Silicon Carbide (SiC) Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs) through the development and implementation of sophisticated three-dimensional Technology Computer-Aided Design (3D TCAD) methodologies. These advanced simulation techniques enable comprehensive evaluation of innovative unit cell architectures that remain inaccessible to conventional two-dimensional (2D) TCAD approaches. By leveraging these 3D simulation capabilities, this work facilitates significant improvements in both the performance and reliability of next-generation wide-bandgap power devices.

Power devices convert electrical energy between different forms throughout the power grid making them essential in applications ranging from personal electronics, electric vehicles, renewable energy systems, industrial …

The Response Of Tropopause Phenomena To Stratospheric Variability: Rossby Wave Breaking And Tropopause Polar Vortices, Cameron R. Paquette

Electronic Theses & Dissertations (2024 - present)

Variability in the high-latitude wintertime stratospheric flow, often referred to as the stratospheric polar vortex, can precede anomalous conditions in tropospheric flow on subseasonal-to-seasonal (S2S) timescales and impact surface weather. The range of stratospheric impacts on tropospheric conditions range from shifts in the North Atlantic storm tracks, formation of cold spells, and development of extreme precipitation. Impacts of stratospheric variability are known to persist for up to 60 days, providing ample windows of opportunity in forecasting on S2S timescales. This dissertation focuses on the stratospheric impacts on tropopause-level processes, such as Rossby wave breaking (RWB) events and tropopause polar vortices …

A Systematic Review And Meta-Analysis Examining The Impact Of The First Step To Success/First Step Next Intervention: A Pbis Tier 2 Intervention For Pre-K - 3rd Grade Students, Shawna L. Belanger

Electronic Theses & Dissertations (2024 - present)

Students with or at risk for emotional and behavioral disorders often experience significant challenges that adversely affect their academic performance and overall well-being. Although the First Step to Success/First Step Next (FSS/FSN) intervention has been widely implemented as a PBIS Tier 2 intervention to support Pre-K to 3rd-grade students with challenging behaviors, research findings have been inconsistent. This systematic review and meta-analysis synthesizes the literature on the intervention’s effectiveness across studies, focusing on both social-emotional behavioral outcomes and academic performance.

Using a comprehensive search strategy, studies meeting rigorous inclusion criteria were identified, and effect sizes (Hedges’s g) were calculated to …

Intention-Setting Among Recreational Psychedelic Users: Associated Acute Effects And Changes In Well-Being, Zi Ling Fiona Low

Electronic Theses & Dissertations (2024 - present)

Psychedelic intentions play an important role in shaping acute psychedelic experiences and influencing long-term outcomes. Limited existing literature suggests that different types of intentions are linked to acute experiences and outcomes in varying ways. However, data on the types of intentions set by recreational users remain scarce, and their effects lack clarity. This study investigates intention-setting practices among recreational psychedelic users, aiming to establish a taxonomy of intentions in naturalistic use contexts and clarify user perspectives on the impact of intention-setting. We also examine how domain-specific intentions correlate with acute psychedelic effects and changes in well-being. Finally, we test a …

A Theoretical And Empirical Adaptation Of Signaling Theory For Digital Communication: Examining Organizational Brand Identity And Credibility, Victoria Barbeisch

Electronic Theses & Dissertations (2024 - present)

This dissertation adapts signaling theory for digital communication and tests its relevance in strategic communication, specifically concerning unobservable organizational traits like brand identity values. Signaling theory explains how parties with unequal information (senders/signalers and receivers) use signals to bridge knowledge gaps and influence decision-making. While rooted in biology and economics, its application in computer-mediated communication (CMC) remains limited. This research addresses this gap through two primary aims. Aim 1 presents the first comprehensive theoretical adaptation of signaling theory for digital communication, consolidating fragmented research across multiple disciplines. Aim 2 investigates the theory's relevance in strategic communication related to unobservable brand …