Digital Commons Network^™

Assessing How Early Vs. Late Exercise Influences Whole Body Glucose Tolerance And Insulin Signaling Pathways In Quadriceps During Social Jetlag, Ariana Khzarjyan, Austin Cooper, Paula Martinez, Joshua Corpuz, Srushti Wagh, Elias Malek, Todd Schrubb

Undergraduate Research Symposium Posters

BACKGROUND: Circadian rhythms regulate our physiological and metabolic processes throughout a 24-hour cycle. Disruptions to this rhythm with modern lifestyles creates irregular patterns. One of the most common forms of circadian rhythm disruptions amongst humans happens during the weekends, when people tend to stay up later and sleep in later compared to weekdays. This phenomenon is referred to as social jetlag (SJL).

PURPOSE: To determine whether timed exercise (early vs. late) can reduce the negative effects of social jetlag in mice. More specifically, determining whether exercise conducted in the early or late active phase of mice will impact the effects …

Pragmatic Textualism, Brian G. Slocum, Kevin Tobia

Duke Law Journal

Traditional textualism instructs judges to adhere to a statute's linguistic meaning and reject as irrelevant its interpretive consequences. Justice Scalia famously contrasted his restrained textualist judge with "Mr. Fix-It," a judge who inappropriately weighs consequences. Today, however, textualists increasingly embrace consequentialist reasoning. This Article documents this undertheorized shift and the emerging textualist efforts to justify it, including Justices Kavanaugh and Barrett's arguments for nonliteralism and judicial sensitivity to context. This Article critiques these efforts: Modern textualist theory lacks a compelling explanation for its newfound reliance on interpretive consequences.

Next, we offer a novel theory of the linguistic role for interpretive …

An Examination Of Disparities In Adhd Diagnosis Between Men And Women, Julia Holloway

University Honors Theses

Attention Deficit Hyperactivity Disorder has become an increasingly popular area of study over the last decade. The rise in cases over the same period likely explains this trend, as does ADHD’s status as one of the most commonly encountered neurodevelopmental disorders. While much of this research has served as an invaluable asset to both practitioners and patients there are still blind spots which have yet to be addressed by the existing body of research. This progress in our understanding of ADHD has gone far in illuminating the biases which have set the precedent for treatment and diagnosis, however, widespread understanding …

Art And Critical Thinking, Audrey Nixon

University Honors Theses

The voice of art molds and dictates norms and behaviors of society. Art eases people into sitting with discomfort or alternate ideas of the world. I work with mixed-media collage to respond and react to culture and the current American political climate. Through the act of expressing and working through thoughts and emotions, art teaches people how to process, it teaches histories of resistance, and empathy. Artists have the ability to engage their audience to critically think about what is happening in our world. By channeling expression and passion, art can help people make necessary connections about concepts that lead …

“Ready, Set, Prepared!” Promoting Household Emergency Preparedness Of Older Adults, Lavonne M. Adams, Charleen Mcneill, William Ellery Samuels, Tara Heagele

Biennial Convention (CONV)

Abstract Text: Introduction Older adults are at-risk for injury, illness, or death following a disaster or public health emergency, especially if they have chronic health conditions or other functional needs. Understanding their unique perspectives may inform education efforts to improve their household emergency preparedness (HEP) and safety.

Purpose This study investigated self-reported levels of HEP among community-dwelling older adults, exploring feasibility and effectiveness of offering group education virtually and in-person. It built on previous studies of the Nurses Taking on Readiness Measures intervention that examined short-term effectiveness of one-on-one HEP education.

Methods The design was a non-randomized before-after feasibility study …

Graphic Narratives On The Us-Mexico Border: Educational Tools To Improve Health Literacy, Sarah Y. Jimenez, Jacob Martinez, Melissa Wholeben

Biennial Convention (CONV)

Purpose: Using graphic medicine narratives to disseminate health information has emerged as an innovative teaching strategy. Graphic medicine draws on interdisciplinary expertise to communicate complex health information through vibrant imagery and relatable character dialogue using comics or animation. This presentation will discuss three research projects in which graphic narratives were developed in English and Spanish and used to enhance health knowledge among individuals, families, and healthcare providers living on the U.S.-Mexico border. Health topics addressed included brain health promotion, self-care techniques for dementia caregivers, HPV vaccine uptake and cancer prevention, and trauma-informed care strategies for emergency department nurses. This presentation …

Understanding The U.S. Maternal Healthcare System At The Intersection Of Asian American Birth Outcomes And The Model Minority Stereotype: A Literature Review, Sophia Hevel

University Honors Theses

This thesis aims to explore the maternal healthcare system in the United States as it pertains to Asian American birthing people, the ways in which their racial, ethnic, and cultural identities are interacted with within the U.S. Healthcare system, and subsequently the detrimental effects of the medical system's devaluation of culturally specific birthing and postpartum practices have on Asian American birthing experiences. This will be accomplished through an exploration of the United States' maternal healthcare system, or rather, its crisis; how Asian Americans navigate a system that has not been structured to support their specific needs; and lastly, a discussion …

Risk Factors For Unexpected Death In Patients Identified By A Communication And Resolution Program, Peter Lodato, Neal D. Goldstein, Alexandra M, Mapp, Adebayo Gbadebo, David A. Paul

Department of Pediatrics Faculty Papers

Many patients experience unexpected harm while receiving healthcare, with a lasting impact on patients, families, and caregivers. Communication and Resolution Programs are being adopted with increased frequency, as a more systematic, transparent, and equitable approach to these unexpected outcomes. The aim of this study was to identify whether demographic factors played a role in identifying patients with unexpected death, as managed in our CRP. This nested case-controlled compared 236 patients who experienced an unanticipated death with 2,360 controls who died expectedly over a 10-year period. Patients with unexpected death were more likely to be Black (AOR 2.18 95% CI 1.01-4.68), …

Who Was It Truly For?: Bernard Bragg, David Hays, And National Theatre Of The Deaf, Eni Buckhanan

Honors Theses

National Theatre of the Deaf is known for being the first professional sign language theatre company in the United States; however, the complexities of its origins and founders are rarely examined. This thesis explores the relationship between Deaf performer and educator Bernard Bragg and hearing set designer David Hays, along with what was prioritized in the creation of the company, and the aftereffects of these choices on the National Theatre of the Deaf and their Deaf and hearing audiences.

Bragg and Hays began correspondence in 1966, as they developed plans for what would become the National Theatre of the Deaf. …

Exploring Private And Governmental Interest In Bitcoin, Mina Khadem

Undergraduate Theses, Capstones, and Recitals

Regardless of one’s opinion, Bitcoin’s presence in the global economy is growing. However, Bitcoin’s emerging role and its implications are greatly under-researched, particularly in the context of government interest in Bitcoin. Nonetheless, increased private investment in Bitcoin and increased government interest in formally incorporating Bitcoin into existing economic systems, suggest a new development within the global economy that must be investigated. Through qualitative text analysis of pro-Bitcoin narratives presented in digital media platforms and official government policies and public statements, this thesis explores how private and government interest in Bitcoin is explained and framed within these contexts. This study finds …

Bridging Worlds: Cultivating Cultural Intelligence For Transformative English Classrooms, Alvaro R. Larrea Salazar

Senior Honors Theses

This project explores the integration of the Cultural Intelligence (CQ) framework in the secondary English classroom to enhance inclusivity and classroom dynamics. It argues that by understanding and adapting to diverse cultural contexts, teachers can create a more inclusive and welcoming environment, improve teacher-student relationships, and facilitate more effective classroom management. Through a focus on lesson planning, discussion, and overall instruction, this thesis aims to show how CQ can enrich literature studies and foster cultural awareness among students. Drawing on existing research, it demonstrates that a high CQ in educators is linked to transformational leadership and positive student outcomes, ultimately …

Considerations And Guidelines For Clinical Training And Professional Practice In The Area Of Psychotherapy Termination, Elyssa L. Jampolsky

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Treatment termination occurs, invariably, in every psychotherapy relationship. Closing the therapy relationship is often a complex process and requires targeted training for psychotherapists to terminate treatment competently and in a way that preserves gains made and fosters continued client growth. Discontinuation of psychotherapy services requires practitioners to apply ethical knowledge, clinical expertise, and relational boundaries. Further, the nuances of forced, end-of-year termination in clinical training environments necessitates targeted supervision and explicit guidelines. Surprisingly, termination practices are underemphasized in training programs and in the literature. The current paper will review the extant literature related to psychotherapy termination broadly as well as …

Non-Invasive Infection Detection Framework: Smartphone-Based Hematologic And Thermal Biomarker Monitoring, Nafi Us Sabbir Sabith

Dissertations (1934 -)

Infectious diseases remain one of the leading global causes of illness and death in both community and hospital settings. Infections lead to lasting health issues, such as life-threatening chronic conditions or even cancer. Early detection is crucial for timely intervention, such as isolation and treatment. Hematology originated from the Greek word haima, meaning blood. It is a unique discipline in medicine that involves the study of blood and its contents. White blood cells (WBC) are at the forefront of the body’s immune system. WBCs are categorized into five main subtypes: neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Monitoring the total WBC …

Interview No. 1814, Virginia Prebot

Combined Interviews

Virginia Prebot, a veteran now studying at the University of Texas at El Paso, illustrates how language shapes daily life and preserves memory across generations. Born in Riverside, California, to two Mexican immigrant parents, she grew up in a world where Spanish was the grounding force of her home, her school, and her community.

Welcoming us into the quiet of her home, with her dogs resting nearby, Virginia invited us into her story. She spoke of childhood moments on the playground and her time in English as a Second Language (ESL), recalling how Spanish remained constant through every stage of …

Institutional Mobility Intentions And Job Satisfaction Of Model Minority University Faculties In The United States, Maki Kato

Journal of Comparative & International Higher Education

The purpose of this study is to quantitatively understand the institutional mobility intentions and job satisfaction of Asian Female Foreign Faculties (AFFFs) working in colleges and universities in the United States (U.S.) to supplement previous qualitative research focusing on their experiences and perceptions. This study uses 2012–2020 data from the Collaborative on Academic Careers in Higher Education’s (COACHE) Faculty Job Satisfaction Survey. The results show that among both, AFFFs and other foreign faculties, the intention to move from one’s current university is uncertain. AFFFs’ job satisfaction, including their interactions with other faculties, is lower than that of white U.S. …

An Investigation Of International Students’ Satisfaction With Their University Experience Using An Expectation Confirmation Theory Lens, Mehraz Sarker, Jonathan Worae, Jason D. Edgerton

Journal of Comparative & International Higher Education

This study examines how various challenges and support systems influence international students’ satisfaction, as reflected in their intention to recommend their university. Using the Expectation Confirmation Theory (ECT), it examines whether students’ initial expectations moderate the relationships between challenges and satisfaction, and between institutional support and satisfaction. Analysis of survey data (N = 712) indicates that the majority of international students report satisfaction with their university experience. Ordinal logistic regression analyses reveal that perceived institutional support and higher initial expectations are associated with increased likelihood of recommending the university. Conversely, academic and discrimination challenges are associated with decreased likelihood of …

Cultivating A Sense Of Community: International Students Navigating Community Engaged Learning Opportunities In Line With Their Social Goals, Katherine Lyon, Nicole Malette

Journal of Comparative & International Higher Education

International students often envision their time studying abroad with particular academic, professional, social, linguistic, and identity-related goals in mind (Fong, 2011; Jones, 2013; Montgomery & McDowell, 2009; Page, 2019; Page & Chahboun, 2019). Post-secondary institutions can provide resources and opportunities to help this heterogeneous group of students bring their vision into fruition. One such opportunity is community engaged learning (CEL), which has been shown to help students expand their social and academic abilities as they make contributions to an organization (Arnold, 2019; Greenberg, London & McKay, 2020; Mayer et al., 2019). Through in-depth interviews with 25 new international students who …

Characterizing Global Dermatologic Engagement And Needs: A Cross-Sectional Study From 83 Countries, Alexis G. Strahan, Christine Li, Maud Guérin, Tom Allison, Gene Colón, Jehireh Peraza-Williams, Olyvia Zarchin, Morvarid Zehtab, Ann M. Pacheco, Jadesola Akinwuntan, Shivani Jain, Marlous L. Grijsen, Wendemagegn Enbiale, Wingfield Rehmus, L. Claire Fuller, Karolyn Wanat, Esther E. Freeman

School of Medicine Faculty Publications

No abstract provided.

Museums In Public Libraries: An Ethnographic Case Study Of The Blair-Caldwell African American Research Library, Yadira Y. Quintero

Electronic Theses and Dissertations

Access to information is a human right, and this thesis explores the benefits and challenges of integrating museums into public libraries by conducting an ethnographic case study of the Blair-Caldwell African American Research Library. The study's findings highlight the complexities of integration. The biggest benefit is the increased access to museum collections, information, and resources. However, challenges arise from the lack of cohesion within the museum and library disciplines, as well as strained community relations. Engaging the community is crucial for successful collaboration, emphasizing the importance of a bottom-up approach that allows for active participation. Integrating museums into public libraries …

Doughnut Economics And Strong Sustainability: Rethinking The Role Of Financial Investment, Isabelle Pierotti

Electronic Theses and Dissertations

This thesis investigates how private investment could align doughnut economic framework. Doughnut economics is a strong sustainability economic framework where the economy operates within planetary boundaries while ensuring social equity. Theories of sustainable development, weak sustainability, and strong sustainability are discussed to provide theoretical context for doughnut economics and mainstream economics. The analysis concludes that conventional, profit maximizing private investment does not support a doughnut economics system by supporting the depletion of natural resources and exacerbating social issues. Sustainable mainstream investment also fails to support a doughnut framework. Lastly, while impact investment is theoretically committed to social and financial returns, …

An Auto-Criticism: Exploration Of Professional Development For Secondary Science Educators, Mellissa Ann Pfaff

Electronic Theses and Dissertations

This auto-criticism investigates the benefits of experiential professional development for science educators by examining the reflective journey of one teacher-researcher—me—through multiple immersive learning experiences. Using narrative journaling and qualitative analysis, this study captures the influence of these experiences on my identity, instructional design, and ability to create experiential learning opportunities for students.

Rather than approaching professional development as a checklist of strategies, this research seeks to illuminate how deeply engaged, hands-on learning can transform teaching from routine delivery to embodied practice. Thematic coding revealed shifts in curriculum planning, increased responsiveness to student inquiry, and renewed clarity around the purpose of …

Capacity, Allocation And Update Dynamics Of Human Memory Systems, Shaoying Wang

Electronic Theses and Dissertations

Information is encoded and stored in three types of memory: sensory memory (SM), short-term memory (STM), and long-term memory (LTM). SM has a large capacity but retains information for only a brief period. When information transfers to STM, only a limited amount can be stored. Information in STM can then be transferred to LTM, which has a much larger capacity and longer retention time. STM is often conceptualized as working memory (WM) to highlight its role in active information processing. Due to the limited capacity of STM, it is commonly believed that STM serves as the bottleneck for information processing. …

Archaeological Predictive Meta-Modeling In Pre-Columbian Mexico, Peter Stamm

Electronic Theses and Dissertations

Archaeological Predictive Modeling stands firmly as an important tool for Archaeologists to predict undiscovered sites from civilizations all across the globe. While powerful, this methodology is not without its own set of qualms. Striking a balance between pure a data-driven approach while also observing leading expert theories can be a complicated task. Going further, deciding on the specific domain of features to emphasize or overlook can be a challenge within itself, as one misstep can drastically change the output of model, sometimes for the worst. In addition, creating models that can expose their reasoning process can be rather difficult to …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

The Time-Dependent Association Between Irritable Bowel Syndrome And All-Cause And Cause-Specific Mortality In The Nih-Aarp Cohort Study, Shreela V Sharma, Qing Lan, Maki Inoue-Choi, Baharak Moshiree, Paul Albert, Rashmi Sinha, Emily Vogtmann

Faculty, Staff and Student Publications

Introduction: Evidence on the association between irritable bowel syndrome (IBS) and mortality is conflicting. In this study, we estimated the association between IBS and all-cause and cause-specific mortality in the NIH-AARP Diet and Health Study.

Methods: IBS diagnoses between 1994 and 2008 were identified from Medicare claims data, and mortality outcomes through 2019 were obtained through linkage to the National Death Index. Using multivariable Cox proportional hazards regression models, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality within partitioned follow-up time categories (>2-5, >5-8, >8-11, >11-14, >14-17, and >17 years) with adjustment …

Deletion Of Fibro-Adipogenic Progenitors-Specific Follistatin Impairs Muscle Function And Accelerates Skeletal Muscle Atrophy In Obese Mice, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki Miwa, Takumi Era, Martin M Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe

Faculty, Staff and Students Publications

Background: Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury. The mechanism by which fibro-adipogenic progenitors (FAPs)-specific follistatin influences muscle homeostasis in obese mice remains unknown. Therefore, we investigated the physiological role of follistatin in PDGFRα-positive FAPs in the regulation of muscle homeostasis and exercise in obese mice.

Methods: A PDGFRα-specific follistatin knockout (follistatin KO) mouse model was generated using PDGFRα-GFP-CreERT2 (PDGFRα-GCE) and follistatinflox/flox mice. These mice were fed a 60% high-fat diet (HFD) for 20 weeks, followed …

Multi-Parametric Profiling Of Il-7-Augmented Gd2cart Products In A Phase 1 Clinical Trial, Lukas Ehlen, Stephan Schlickeiser, Samira Picht, Lena Peter, Marco Mai, Candise L Tat, Jacqueline Keye, Desiree Kunkel, Frank Lin, Cliona M Rooney, Bilal Omer, Michael Schmueck-Henneresse

Faculty, Staff and Students Publications

CAR T cell (CART) therapy holds promise for cancer treatment, but heterogeneity among products limits clinical effectiveness, making systematic profiling essential to identify predictors of success. Recently, a phase 1 clinical trial investigated whether a constitutively active IL-7 receptor (C7R) could safely improve the function and persistence of GD2-directed CARTs (GD2.CARTs) in pediatric patients with high-grade CNS tumors. We analyzed infusion products from trial participants using a custom-designed 33-color full spectrum flow cytometry (FSFC) panel combined with an image-based tumor killing assay to characterize CART products and evaluate the impact of C7R on GD2.CART performance. Patient-specific variations in T cell …

Diras3-Derived Cyclic Peptides Disrupt Kras-Raf Interaction And Kras Nanoclustering, Suppressing Kras-Driven Pancreatic And Ovarian Tumors, Margie N Sutton, Jing Wang, Amarachi O Osuji, Nefeli Batistatou, Hailing Yang, Weiqun Mao, Zhi Tan, Geneviève M C Gasmi-Seabrook, Junchen Liu, John F Hancock, Christopher B Marshall, Joshua A Kritzer, Mitsuhiko Ikura, Robert C Bast, Steven W Millward, Zhen Lu

Faculty, Staff and Students Publications

Mutations in KRAS drive 88% of pancreatic ductal adenocarcinomas (PDAC) and up to 40% of low-grade serous ovarian cancers (LGSOC), making KRAS a long-standing therapeutic target. We previously showed that DIRAS3 binds RAS, forming heterodimers that disrupt RAS clustering and downstream MAPK signaling. Building on this, we developed conformationally constrained DIRAS3-derived peptides using two cyclization strategies and characterized them by NMR and biolayer interferometry. These cyclic peptides attenuate the interaction between KRAS and the BRAF RAS-binding domain, penetrate cells efficiently, and inhibit KRAS nanoclustering on the inner leaflet of the plasma membrane. Functionally, they reduce cell viability and suppress PDAC …

Alteration Of Gut Microbial Ecology By The Direct Activation Of The Brain: Inverse Gut-Microbiome-Brain Dynamics, Mikhail Y Kochukov, Shelly A Buffington, Sean W Dooling, Benjamin R Arenkiel, Mauro Costa-Mattioli

Faculty, Staff and Students Publications

The gut-microbiome-brain axis is a bidirectional communication system influencing host physiology and overall fitness. While "bottom-up" effects-where gut microbes influence brain function and behavior-are well established, direct evidence for "top-down" modulation-where the brain shapes the gut microbial ecology-remains elusive. Here, we show that the selective expression of the bacterial ion channel mNaChBac in glutamatergic lateral habenula (LHb) neurons increases their bursting activity and leads to endophentypes associated with depression. Importantly, this chronic activation leads to changes in the gut microbiome composition over time, as reflected by shifts in alpha-diversity and alterations in specific microbial taxa. These findings provide direct evidence …

Identifying Compounds To Treat Opiate Use Disorder By Leveraging Multi-Omic Data Integration And Multiple Drug Repurposing Databases, Melyssa S Minto, Logain Elnimeiry, Ravi Mathur, Matthew Schu, Bryan C Quach, Javan Carter, Tracy Nolen, Nathan Vandergrift, Thomas R Kosten, Eric Otto Johnson, Bradley T Webb

Faculty, Staff and Students Publications

Genes influencing opioid use disorder (OUD) biology have been identified via genome-wide association studies (GWAS), gene expression, and network analyses. These discoveries provide opportunities to identifying existing compounds targeting these genes for drug repurposing studies. However, systematically integrating discovery results and identifying relevant available pharmacotherapies for OUD repurposing studies is challenging. To address this, we've constructed a framework that uses existing results and drug databases to identify candidate pharmacotherapies. For this study, two independent OUD related meta-analyses were used including a GWAS and a differential gene expression (DGE) study of post-mortem human brain. Protein-Protein Interaction (PPI) sub-networks enriched for GWAS …