Digital Commons Network^™

Exploring Recruitment Strategies For Place-Based Research In Rural Areas Of Australia: A Comparative Case Study Analysis, Tracy L. Schumacher, Anna K. Jansson, Lucy Kocanda, Jennifer May Phd, Rn, Anp-Bc, Leanne J. Brown, Clare E. Collins

Publications

BACKGROUND: Recruitment of participants into research studies is commonly challenging and becomes more difficult when targeting underrepresented population groups. Recruiting individuals living in rural locations, must use appropriate strategies if the sample size is to be achieved. The aim of this case study was to explore factors associated with research capacity, and to determine their impact on recruitment strategies, including timeframe and participant recruitment outcomes.

METHODS: This case study investigated the recruitment outcomes of four rurally based research projects performed between 2016-2024. Participants were enrolled either directly by the researchers (face-to-face method [f2f]), or through General Practitioners as trusted local …

Transcription-Replication Collisions Trigger High-Fidelity Replication Reset, Katelin M Hagstrom, Alice X Wen, Jennifer A Halliday, Susan M Rosenberg, Christophe Herman

Faculty, Staff and Students Publications

Double-stranded DNA ends arise from external agents or cellular processes like transcription-replication collisions (TRCs), threatening genome stability. Here, we performed genomic CRISPRi screens to uncover DNA end formation factors in Escherichia coli. We discovered that translation-transcription decoupling causes DNA end formation through a TRC-dependent pathway, which is lethal when DNA end processing by RecBCD is disrupted, but not when recombination is disrupted. We find that TRCs cause replisome stalling followed by "rear-ending" from trailing replisomes which generates free DNA ends, rather than strand breaks. Surprisingly, these DNA ends are resolved through a process we call "replication reset", where the stalled …

Investigating The Neuronal Role Of The Proteasomal Atpase Subunit Gene Psmc5 In Neurodevelopmental Proteasomopathies, Amélie Bosc-Rosati, Tzung-Chien Hsieh, Lise Bray, Marielle Oloudé, Cory Rosenfelt, Marie Pier Scott-Boyer, Victoria Most, Tianyun Wang, Jonas J Papendorf, Charlotte De Konink, Wallid Deb, Virginie Vignard, Maja Studencka-Turski, Thomas Besnard, Anna M Hajdukowicz, Franziska G Thiel, Sophie Wolfgramm, Laëtitia Florenceau, Silvestre Cuinat, Sylvain Marsac, Yann Verrès, Audrey Dangoumau, Léa Poirier, Ingrid M Wentzensen, Annabelle Tuttle, Cara Forster, Johanna Striesow, Richard Golnik, Damara Ortiz, Laura Jenkins, Jill A Rosenfeld, Alban Ziegler, Clara Houdayer, Dominique Bonneau, Erin Torti, Amber Begtrup, Kristin G Monaghan, Sureni V Mullegama, Catharina M L Nienke Volker-Touw, Koen L I Van Gassen, Renske Oegema, Mirjam S De Pagter, Katharina Steindl, Anita Rauch, Ivan Ivanovski, Kimberly Mcdonald, Emily Boothe, Andrew Dauber, Janice Baker, Noelle Andrea V Fabie, Raphael A Bernier, Tychele N Turner, Siddharth Srivastava, Kira A Dies, Lindsay C Swanson, Carrie Costin, Alali Abdulrazak, Rebekah K Jobling, John Pappas, Rachel Rabin, Dmitriy Niyazov, Anne Chun-Hui Tsai, Karen Kovak, David B Beck, May Christine V Malicdan, David R Adams, Lynne Wolfe, Rebecca D Ganetzky, Colleen C Muraresku, Davit Babikyan, Zdeněk Sedláček, Miroslava Hančárová, Andrew T Timberlake, Hind Al Saif, Berkley Nestler, Kayla King, M J Hajianpour, Gregory Costain, D'Arcy Prendergast, Chumei Li, David Geneviève, Antonio Vitobello, Arthur Sorlin, Christophe Philippe, Tamar Harel, Ori Toker, Ataf Sabir, Derek Lim, Mark J Hamilton, Lisa J Bryson, Elaine Cleary, Sacha Weber, Trevor L Hoffman, Anna M Cueto-González, Eduardo F Tizzano, David Gómez-Andrés, Marta Codina-Solà, Athina Ververi, Efterpi Pavlidou, Alexandros Lambropoulos, Kyriakos Garganis, Marlène Rio, Jonathan Levy, Sarah J Langas, Anne M Mcrae, Mathieu K Lessard, Maria Daniela D'Agostino, Isabelle De Bie, Meret Wegler, Rami Abou Jamra, Susanne B Kamphausen, Viktoria Bothe, Lorraine Potocki, Eric Olinger, Yves Sznajer, Elsa Wiame, Michelle L Thompson, Molly C Schroeder, Catherine Gooch, Raphael A Smith, Arti Pandya, Larissa M Busch, Uwe Völker, Elke Hammer, Kristian Wende, Benjamin Cogné, Bertrand Isidor, Jens Meiler, Clémentine Ripoll, Stéphanie Bigou, Frédéric Laumonnier, Peter W Hildebrand, Evan E Eichler, Kirsty Mcwalter, Peter M Krawitz, Florence Roux-Dalvai, Ype Elgersma, Julien Marcoux, Marie-Pierre Bousquet, Arnaud Droit, Jeremie Poschmann, Andreas M Grabrucker, Francois V Bolduc, Stéphane Bézieau, Frédéric Ebstein, Elke Krüger

Faculty, Staff and Students Publications

Neurodevelopmental proteasomopathies are a group of disorders caused by variants in proteasome subunit genes, that disrupt protein homeostasis and brain development through poorly characterized mechanisms. Here, we report 26 distinct variants in PSMC5, encoding the AAA⁺ ATPase subunit PSMC5/RPT6, in individuals with syndromic neurodevelopmental conditions. Combining genetic, multi-omics and biochemical approaches across cellular models and Drosophila, we unveil the essential role of proteasomes in sustaining key cellular processes. Loss of PSMC5/RPT6 function impairs proteasome activity, leading to protein aggregation, disruption of mitochondrial homeostasis, and dysregulation of lipid metabolism and immune signaling. It also compromises synaptic balance, neuritogenesis, and neural progenitor …

Waiting Room And Hallway Care For Older Adults: A Qualitative Study With Emergency Nurses And Technicians, K Jane Muir, Anita N Chary

Faculty, Staff and Students Publications

Background: Emergency Department (ED) crowding places older ED patients at risk for adverse outcomes. Crowding often necessitates ED waiting room and hallway care, but there has been limited research on approaches to care for older adults in these settings. Frontline clinician insights can inform best practices for older adults in the context of the ongoing ED crowding crisis. Our objective was to describe the experiences of emergency nurses and technicians in providing waiting room and hallway care for older adults.

Methods: This qualitative study used individual, semi-structured interviews with a purposive sample of 20 ED nurses and technicians at a …

Multimodal Cardiac Imaging Of Immune-Mediated Complications Post Heart Transplantation: A Contemporary Review, James C Wilkinson, Marvin W Kronenberg, Chloe Carr, Malek Nayfeh, Tania Ruiz, Luke L Laws, Melissa Lou Silva, John A Wells, Leandro Slipczuk, Emily T Lippincott, John J Carr, Kaushik Amancherla, Cameron Henry, David Parra, Kelly Schlendorf, Quinn S Wells, Sean G Hughes, Jonathan Soslow

Faculty, Staff and Students Publications

Heart transplantation significantly enhances survival and quality of life for patients with end-stage heart failure. Despite advances in surgical and postoperative care, immune-mediated complications, acute graft rejection and cardiac allograft vasculopathy (CAV), remain major barriers to long-term success. Acute rejection predominantly affects early posttransplant survival, whereas CAV becomes a leading cause of mortality in later years. The gold standards for diagnosis, endomyocardial biopsy for rejection and coronary angiography for CAV, are invasive and imperfect. Noninvasive multimodality imaging is increasingly used to complement or, in selected scenarios, defer invasive testing. Echocardiography with strain detects early myocardial dysfunction when ejection fraction is …

Phase Equilibria Modeling Constraints On Channel Flow Of Metasedimentary Crust Beneath The Southeastern Tibetan Plateau, Govind Joshi, Gregory Dumond

Geosciences Faculty Publications and Presentations

Lower crust of the southeastern Tibetan Plateau includes 100 s of km2-scale zones of low resistivity at 20-40 km-depths indicating the presence of melt +/- fluid +/- graphite. These zones coincide with interconnected zones of low shear wave velocity. Data from central and southeastern Tibet support the occurrence of meta-sedimentary felsic granulites in the lower crust along a backarc-like geothermal gradient. Phase equilibria modeling of average metasedimentary pelite and greywacke bulk compositions constrained by these geophysical data explored the impact of partial melting on shear wave velocity for a range of fluid content. Low shear wave velocities beneath southeastern Tibet …

Neuropsychiatric Research Databases For People With Intellectual Disabilities And Epilepsy (Refine): A Feasibility Study Protocol, Crispin Musicha, Helen Neilens, Emily Stanyard, Victoria Allgar, Joe Lomax, Ryan Ashford, Helen Hambly, Paigan Aspinall, Emma O’Shaughnessy, Chris Rollinson, Sarah Lennard, Brendan Mclean, Anna Simpson, Pamela Bowman, Heather Angus-Leppan, Lance Watkins, Richard Laugharne, Jon Allard, Rohit Shankar

Peninsula Medical School

Introduction This project explores the feasibility of setting up a neuropsychiatric de-identified database (DiD) and a Research Register (RR) to collect, analyse, monitor and systematically report clinical data for people with intellectual disabilities (PwIDs) and epilepsy.Methods and analysis A multicentre project designed to collect de-identified data from clinical records at three adult ID specialist services in England and Wales and to develop an RR of PwID and epilepsy. Patients added to the DiD will be identified from patient clinic lists, clinic letters, in-house databases and electronic systems. Patients to be added to the RR will also be identified through attendance …

Exploring Experiences Of Mental Health Challenges In Under-Represented Young People (Aged 16–24 Years) In England: A Narrative Inquiry Protocol, Rebecca Syed Sheriff, Jason Arday, Rohit Shankar, Roisin Mooney, Louise Chandler, Helen Adams, Lili Z Nagy, Roger Farrell, Daisy Fancourt, Scott Weich, Catherine Henderson, Shaima Hassan, Joe Langley, Kamaldeep Bhui

Peninsula Medical School

Introduction Three-quarters of mental health problems start before the age of 25. However, young people are the least likely to receive mental healthcare. Some young people (such as those from ethnic minorities) are even less likely to receive mental healthcare than others. Long-term impacts of mental health problems include poorer physical health, relationships, education and employment. We aim to elicit the views, experiences and needs of diverse young people (aged 16–24 years), to better understand (1) their experiences of under-representation, mental health and coping, (2) mechanisms that shape mental health trajectories and (3) how online arts and culture might be …

Majority In Nh & Southern New England Plan To Eat Turkey For Thanksgiving, One In Six Traveling Outside Of State 11/26/2025, Unh Survey Center

All UNH Survey Center Polls

A majority of residents of New Hampshire and Southern New England (57%) plan to eat turkey for Thanksgiving this year, 28% plan to watch football, 26% plan to travel somewhere in their state, 25% plan to host friends or family from somewhere else in their state, 17% plan to travel somewhere outside of their state, 12% plan to host friends or family from outside of their state, and 9% do not plan on doing any of these things. Rhode Island residents are most likely to plan to eat turkey and watch football, Massachusetts residents are most likely to travel somewhere …

Data For Social Impact - Data Persona Worksheet, Jenrose Fitzgerald, Dan Ferris, Amelia Parnell

Center for Social Development Research

Developed in collaboration with Amelia Parnell and drawing upon the framework from Parnell's 2021 book You Are a Data Person: Strategies for Using Analytics on Campus, this worksheet facilitates exploration of data identity and the identification of data personas.

Economically Optimal Soil Sampling Density And Application Technology For Potassium Fertilizer For Soybean In The Mid-Southern Us, Bayarbat Badarch, Aurelie Poncet, Shelby Ridar, Nathan Slaton, Michael Popp

Agricultural Economics and Agribusiness Faculty Publications and Presentations

To maximize beneficial potassium (K) fertilizer use in irrigated soybean (Glycine max. (L.) Merr.) fields with spatially varying soil-test K (STK), the value of added information from more precise STK maps must be greater than the associated information collection costs. In eleven fields, we modeled the impact of soil sampling densities (SD) ranging from 2.2 samples ha-1 in the largest field (41.2 ha) to 13.59 samples ha-1 in the smallest field (7.4 ha) on STK maps with 0.4 ha grid size. The accuracy of profit-maximizing fertilizer rate prescription maps varied by SD and subsequent yield estimates using either uniform …

A Practical Framework For Integrating Basic Separation Techniques With Molecular Quantification To Extract And Monitor Antibiotic Resistance Genes In Water Samples, Amani Jereb, Celestene Adrianne Sebag, Asmaa Sadoon, Diksha Shrestha, Mary Savin, Wen Zhang, Yong Wang

Physics Faculty Publications and Presentations

Antibiotic resistance of harmful microorganisms is recognized as a serious threat to human and animal health, which is worsened by the dissemination of antibiotic resistance genes (ARGs). However, it remains challenging to identify ARGs in water samples and to distinguish intracellular (iARGs) and extracellular ARGs (eARGs). In this work, we present a feasibility study to use simple, practical methodologies to extract and distinguish ARGs in water samples using both filtration and centrifugation, followed by quantification using qPCR. Using both synthetic water samples and lake water samples, we demonstrated that the workflow reliably detected and quantified ARGs in synthetic samples. In …

Predicting The Response Of Triple Negative Breast Cancer To Neoadjuvant Systemic Therapy Via Biology-Based Modeling And Habitat Analysis, Casey E Stowers, Chengyue Wu, Clinton Yam, Jingfei Ma, Gaiane M Rauch

Faculty, Staff and Student Publications

Despite being the standard-of-care treatment, neoadjuvant therapy (NAT) attains a complete response only in approximately half of the patients with triple negative breast cancer. Thus, methods to predict and optimize patient response to NAT are needed. Previously, we employed patient-specific MRI data to calibrate a biology-based mathematical model that describes cell movement, proliferation, and death due to drug at the tumor level and cell proliferation at an image voxel level. We now extend our approach by using MRI data to group voxels into "habitats" whereby tumor cells of a habitat share the same proliferation. With this approach, we now calibrate …

Loss Of Idh1 And Idh2 Mutations During The Evolution Of Metastatic Chondrosarcoma, William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Fernanda Amary, Cristina Naceur-Lombardelli, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M Flanagan, Peter Van Loo

Faculty, Staff and Student Publications

Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.

Impact Of Atrial Fibrillation, Diabetes Mellitus, And Obesity On Outcomes With Aspirin Avoidance And Hemocompatibility With A Left Ventricular Assist Device: An Analysis From The Aries-Hm3 Trial, Nir Uriel, Ivan Netuka, Ulrich P Jorde, Francis D Pagani, Jason N Katz, Jean M Connors, Peter Ivak, Daniel Zimpfer, Yuriy Pya, Jennifer Conway, Finn Gustafsson, Sriram Nathan, Anna Mara Scandroglio, Christopher Hayward, David A D'Alessandro, Morgan Collins, Nicholas Dirckx, Mandeep R Mehra

Faculty, Staff and Student Publications

Background: The ARIES-HM3 trial demonstrated the safety and effectiveness of aspirin elimination from the antithrombotic regimen after HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. We explored the interaction of atrial fibrillation, diabetes mellitus, and obesity (AF/DM/Ob) with aspirin elimination on hemocompatibility-related adverse events at 1-year postimplant.

Methods: This prospective, double-blind, placebo-controlled trial randomized patients with an HM3 LVAD implant to receive aspirin (100 mg/d) or placebo, in addition to a vitamin K antagonist. The primary endpoint was survival free of nonsurgical (>14 days postimplant) hemocompatibility-related adverse events, including stroke, pump thrombosis, bleeding, and arterial peripheral thromboembolism at …

Cognitive Testing Of Candidate Items In A Wellbeing Measure Developed For Aboriginal And Torres Strait Islander Peoples, Alana Gall, Gail Garvey, Kate Anderson, Abbey Diaz, Kirsten Howard

Journal of the Australian Indigenous HealthInfoNet

Purpose Health and wellbeing for Aboriginal and Torres Strait Islander peoples is poorly understood, due to commonly used measures of quality of life and wellbeing not aligning with their collectivist worldviews. The need to develop a wellbeing measure, grounded in the aspects of life that Aboriginal and Torres Strait Islander people identify themselves as important, was therefore a priority. The current study aimed to cognitively assess the face and content validity of a new wellbeing measure under development for Aboriginal and Torres Strait Islander adults. Methods We employed a qualitative cross-sectional cohort design. Forty-nine unique draft wellbeing statements underwent cognitive …

Investigating Bilingual Co-Teaching In Kindergarten Classrooms In Abu Dhabi, Fatema Jamal Almahri

Thesis/ Dissertation Defenses

This study investigates the perceptions and experiences of bilingual co-teaching in a school in Abu Dhabi, focusing on how teachers coordinate and collaborate to support students’ learning in both Arabic and English. This study aims to understand how teachers view their roles, challenges, and professional needs when implementing bilingual co-teaching in KG1 and KG2 classrooms.

This study uses a qualitative design with a bilingual open-ended survey that allows teachers to express their views freely and share examples from their daily practice. Eight teachers participated: four from KG1 and four from KG2, each working as part of an Arabic–English co-teaching pair. …

Middle Level English Learners’ Engagement With Digital Multimodal Resources And Each Other, Mark Stevens

Intersections: Critical Issues in Education

Students in schools who speak multiple languages need opportunities for multimodal learning. A study was conducted to observe how middle level English Learners used multimodal (text, audio, video, imagery) resources in a Language Arts - Social Studies class. The research question was: What patterns of engagement with content, and each other, were manifest by middle level ELs while using multimodal resources in a general education history class? Qualitative case study was used to observe student work and interaction, inspect work artifacts, and interview for opinions and motivations. To learn multimodally, students (a) used approaches (whole class, small group, partner) that …

Critical Dialogue As A Decolonial Feminist Approach To Healing And Restoration In Antiracist Literacy Education, Dianne Wellington, Amy Walker

Intersections: Critical Issues in Education

Antiracist work requires healing and restorative practices to sustain meaningful change. This study examines critical dialogue as a restorative practice in literacy education, using duoethnography to explore its role in antiracist efforts. Grounded in decolonial feminist research, we frame healing as an intergenerational movement and literacy education as a catalyst for transformation. Our findings advocate for restorative literacies that challenge systemic oppression, emphasizing relational, justice-driven practices to foster resilience, transformation, and coalition-building in academia. We offer implications for how literacy education can engage lived experiences, histories, and epistemologies to support individual and collective healing.

Sustaining Momentum While Dissertating: The Journey Of Two Women Scholars, Tasha Egalite, Kristin L. Kew

Intersections: Critical Issues in Education

This paper is a narrative reflection on some reasons for earning a doctorate and writing a dissertation. We are two scholars interested in sustaining educational change and dedicated to better understanding and supporting the process and growth of students in doctoral programs. In our pláticas, we share and reflect on our own doctoral journeys, the critical issues we encountered, and the hoops we jumped through while completing our dissertations.

Table Of Contents, Mary F. Rice

Intersections: Critical Issues in Education

No abstract provided.

Moving Forward, Together, Through Critical Dialogue, Mary F. Rice

Intersections: Critical Issues in Education

No abstract provided.

How Do Emirati University Students Develop Their Academic Biliteracy? A Mixed-Method Study, Eman Kamel Rababa

Thesis/ Dissertation Defenses

Framed by Hornberger’s continua of biliteracy model, this study investigated the developmental dynamics of academic biliteracy among Emirati university students. The research employed a sequential mixed-methods design, conducted across three public universities in the UAE. In the initial qualitative phase, interview data were collected from 30 students. Informed by these findings and the extant literature, a quantitative survey was then developed and administered to a sample of 299 students from various disciplines. The qualitative data were analyzed using reflexive thematic analysis, while the quantitative data were examined using advanced statistical analyses, including structural equation modeling. Three primary themes emerged from …

Knitting A Network Of Meaningful Partnership - Implementing An Operational Structure To Drive Success For All, Ronan T. Bree

Teaching and Learning Together in Higher Education

No abstract provided.

Introduction: Building A Student Empowerment And Partnership Programme Driving Innovation And Change Across The Technological Higher Education Sector In Ireland, Carina Ginty, Moira Maguire

Teaching and Learning Together in Higher Education

No abstract provided.

Examining The Impact Of Decreased Snowpack On The Rare Frosted Elfin Butterfly’S Host Plant, Christopher Walsh

Biology Student Scholarship

In response to climate change, Earth’s increased global temperature has caused less snowfall and earlier snowmelt in spring. These changes can alter an organism’s phenology, or timing of life history events. Such shifts in phenology may lead to mismatches between interacting species, which are correlated with a decline in the populations of host plant specialists and at-risk species. The rare frosted elfin butterfly (Callophrys irus) is listed as impaired in 5 states, and critically imperiled in 14. These host plant specialists only lay eggs on small yellow wild indigo (Baptisia tinctoria) and wild lupine (Lupinus perennis). If neither plant emerges …

Current Status And Future Directions For The Use Of Artificial Intelligence In Pediatric Critical Care Nephrology, Sameer Thadani, Christopher M Horvat, Christin Silos, Bronwyn Sutherland, Kristin Dolan, Jin Chen, Ayse Akcan-Arikan, Javier A Neyra

Library Staff Publications

Artificial intelligence (AI) has the potential to significantly improve the practice of medicine. However, its application in pediatric critical care nephrology remains underdeveloped. This scoping review investigates the current state of AI/machine learning (ML) algorithms developed and implemented in the field of pediatric critical care nephrology over more than two decades (2000-2024). We identified 24 articles related to commonly encountered pathologies including acute kidney injury (AKI), electrolyte and acid-base imbalances, fluid management, and dialysis. Twenty (80%) of these articles focused on AKI (prediction and/or detection) and only two articles (4%) investigated the impact of implemented AI/ML models on clinical care …

The Influence Of Muskrats On The Biodiversity Of Wetlands, Emma Thornton

Biology Student Scholarship

Wetlands are one of the most productive ecosystems in the world and are home to various plant and animal species. The relationships between the species living in the wetlands keep the ecosystem functional as well as increasing biodiversity. Increased biodiversity of wetlands creates more resilient plant communities. Muskrats are ecosystem engineers, meaning that they alter their surroundings to change the quality and quantity of the available resources through behaviors related to their eating habits and their burrow construction. Muskrats are herbivores and consume large amounts of vegetation, which creates opportunities for more plant species by creating new ecological niches. In …

Nh Economy: Mixed Feelings But Wide Concern About High Prices 11/25/2025, Unh Survey Center

All UNH Survey Center Polls

More than three-quarters of Granite Staters say prices on everyday items have increased in the past year and a majority expect that to continue. High energy prices are also a major concern. Only one in five expect good business conditions nationally over the next year and a majority believe the country's economy is on the decline. NH residents are similarly pessimistic about their personal finances, with just over a quarter expecting to be better off in a year. However, Granite Staters' estimates of their holiday spending is higher than in previous years and more than two-thirds say they have enough …

Becoming The Stranger, Alyssa Koelewyn

Student Work

"As Christ followers called to welcome the foreigner, how do we put ourselves in the place of the stranger and embrace them?"

Posting about ­­­­­­­­empathy toward people from other cultures from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Becoming the Stranger