Digital Commons Network^™

Loss Of The Lysosomal Protein Cln3 Triggers C-Abl-Dependent Yap1 Pro-Apoptotic Signaling, Neuza Domingues, Alessia Calcagni', Sofia Freire, Joana Pires, Ricardo Casqueiro, Ivan L Salazar, Niculin Joachim Herz, Tuong Huynh, Katarzyna Wieciorek, Tiago Fleming Outeiro, Henrique Girão, Ira Milosevic, Andrea Ballabio, Nuno Raimundo

Duncan NRI Faculty and Staff Publications

Batten disease is characterized by early-onset blindness, juvenile dementia and death within the second decade of life. The most common genetic cause are mutations in CLN3, encoding a lysosomal protein. Currently, no therapies targeting disease progression are available, largely because its molecular mechanisms remain poorly understood. To understand how CLN3 loss affects cellular signaling, we generated human CLN3 knock-out cells (CLN3-KO) and performed RNA-seq analysis. Our multi-dimensional analysis reveals the transcriptional regulator YAP1 as a key factor in remodeling the transcriptome in CLN3-KO cells. YAP1-mediated pro-apoptotic signaling is also increased as a consequence of CLN3 functional loss in retinal pigment …

A Narrative Review Of Dual Loyalty Conflicts In Custodial Settings And Implications For Community Practice, Michelle Suh, Marc David Robinson, Holland Kaplan

Center for Medical Ethics and Health Policy Staff Publications

Dual loyalty dilemmas are conflicts between health care professionals' obligations toward their patients and third-party interests. These conflicts are more common and starker in custodial settings, such as jails and prisons, military detention facilities, immigration detention centers, and involuntary psychiatric institutions. Despite encountering patients in custody, health care professionals (HCPs) in community settings have limited knowledge and training. In this narrative review, we examined dual loyalty conflicts faced by HCPs working in custodial settings and then applied the identified themes to community-based hospitals where HCPs care for patients in custody. We searched databases for original papers relating to patients in …

When 'More Isn't More': The Normative And Practical Case For Improving Genetic Data Infrastructure, Sofia Labrecque, Jonathan Lawson, Bronwyn Danielle Walsh, Vasiliki Rahimzadeh

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

The Effect Of An English Mother Tongue On Spanish Language Acquisition, Erin Wallace

Honors Theses

This study investigates how English influences the Spanish acquisition of English-speaking learners by analyzing written errors, background factors, and interview data. Using two linguistic classification frameworks, it identifies both the types and underlying causes of errors, revealing that gender and plural agreement issues, verb forms, word order problems, and subjunctive misuse are the most frequent difficulties. These errors primarily stem from first-language transfer, overgeneralization, and instructional gaps. The findings highlight the need for targeted practice, contrastive analysis, and greater exposure to authentic Spanish input. Despite limitations such as small sample size and incomplete interview participation, the study offers direction for …

A Story Of Life Through Death: An Osteobiography Of Two Individuals From The Late Saxon Period, Isabella Ragazzi

Honors Theses

The Anglo-Saxons were the most influential inhabitants of the British Isles in the years AD 450-1066, reigning during a time marked by much warfare, pestilence, and famine. Their impact on British history is still seen through archival materials as well as the archeological and bioarchaeological records. A recent development in the field of bioarchaeology is the osteobiography, which places skeletal analysis in context of the overall culture to create the most complete interpretation of the individual and their life history. Involving both traditional bioarchaeological evaluation and isotopic analysis, this method was applied to two Anglo-Saxon skulls donated to the University …

The Impact Of Multiple Measure Placement In Determining College Readiness On Student Perceived Readiness, Steven A. Szeszko Ii

Theses & Dissertations

The purpose of this research is to propose a qualitative grounded theory study that explores the impact of multiple measures placement on determining college readiness as perceived by students, specifically within a community college located in South Central Texas. During the COVID-19 pandemic, colleges and universities found themselves needing an alternative method to the traditional college placement testing to determine student readiness for college courses. This change impacted not only the higher education sector but also students. Therefore, this study will collect data from approximately 20 students, through the use of open-ended electronic student questionnaires and interviews, filtered for patterns …

Building Community Resilience For Disasters In The Wabash Valley, Nathan Myers

2025 Fall Reports (Terre Haute)

As part of the 2025 Indiana State University Sustainable Cities Initiative, we worked on two interconnected research projects: conducting a community needs assessment (as requested by Catholic Charities) and developing a climate-related disaster plan for the City of Terre Haute, Indiana. To complete this work, a student research team examined current statistical information for the Wabash Valley region (including Vigo, Clay, Parke, Vermillion, and Sullivan counties), as well as conducting and analyzing interviews, focus groups, and survey data to determine strengths, challenges, opportunities, and threats related to community resilience in the area. This same information, in conjunction with information from …

Israeli Hasbara And The Nba’S Palestine Exception: The Impossibility Of Capitalist “Social Justice”, Chen Chen, Anthony J. Weems, Roc Rochon, Daniel Sailofsky

Sport Management Collection

Sport is a notable site for the Israeli state in its hasbara (public diplomacy, or “explaining”) effort that seeks to normalize the conditions of ethnic cleansing, illegal settlement, and apartheid practices in historic and occupied Palestine. Against the backdrop of the genocide in Gaza and the lack of international sport sanctions against Israeli teams, this paper maps several hasbara activities/attempts featuring the National Basketball Association (NBA) in the last decade. This is a worthwhile case, not least because of the NBA’s self-branding as a socially “progressive” league composed of a primarily Black/African American athletic workforce. Two major observations are made: …

Differences In Total Daily Energy Expenditure Across Field Sports: A Narrative Review, Brenen Skalitzky, Jennifer Fields, Margaret T. Jones, Chad Kerksick, Andrew Jagim

Faculty Scholarship

Background: Differences in total daily energy expenditure (TDEE) across sports, sex, and skill level support the need for sport- and athlete-specific energy intake recommendations. The purpose of the current review was to examine TDEE and related markers of energy expenditure across field-based team sports. A secondary aim was to evaluate physical activity levels (PAL), calculated as TDEE divided by resting metabolic rate (RMR), and their utility in estimating energy needs within team sports.

Methods: The review was limited to studies that included the field-based team sports of rugby or soccer and reported energy expenditure data using doubly labeled water …

Table Of Contents - Jaepl - Volume 30, Wendy Ryden

The Journal of the Assembly for Expanded Perspectives on Learning

No abstract provided.

Front Matter - Jaepl - Volume 30, Wendy Ryden

The Journal of the Assembly for Expanded Perspectives on Learning

No abstract provided.

Full Issue Of The Journal Of The Assembly For Expanded Perspectives On Learning Volume 30, Wendy Ryden, Jonathan M. Marine

The Journal of the Assembly for Expanded Perspectives on Learning

No abstract provided.

Writing Without Peter: Reflections On Peter Elbow And His Legacy: Peter Elbow The Philosopher, Irene Papoulis

The Journal of the Assembly for Expanded Perspectives on Learning

On the occasion of Peter Elbow’s passing, we read many tributes and praises commemorating him and the foundational contributions he made to the multi-faceted field of writing studies. But as we know, even as Peter’s ideas were lauded and embraced, they were also questioned by many, including other renowned members of our profession.

“Narrative Medicine Saved My Life”: Writing Is A Verb As Well As A Noun, Marian M. Maccurdy, Sarah Robinson

The Journal of the Assembly for Expanded Perspectives on Learning

Dedicated to Professor Peter Elbow 4/14/1935 – 2/6/2025

I, Marian, began my career as a graduate student in medieval literature who had a teaching assistantship to fund her degree. As a graduate student I lived in a world that saw writing as a noun, something done and finished, not as a verb, a process that shows us a world that is as ever-changing as we are. But as a writing teacher I found myself sliding into the world that writers inhabit, and

The Giving And The Receiving: Spiritual Traditions And Teaching, Aepl Summer Conference 2025, Estes Park, Co., Bhushan Aryal, Beverly Brannon, Geri Deluca, Nate Mickelson, Laurence Musgrove, Kristin B. Rajan, Adrian Matt Zytkoskee

The Journal of the Assembly for Expanded Perspectives on Learning

Editor’s note: This past year, AEPL held its first full, in-person conference since the pandemic at our beloved Estes Park location in the Rockies. To commemorate the return of this staple event for our organization, here’s a snapshot of one of the workshops, led by immediate past AEPL Chair, Geraldine DeLuca, “Writing Our Spiritual Autobiographies,” in which DeLuca asked attendees to consider, where and how did we begin, spiritually? What sustains us now? Deluca provided three prompts by Wallace Stevens, Karen Armstrong, and Audre Lorde to aid attendees in their reflection and writing processes. These prompts appear at the end …

Review: Williams, Bronwyn T. Literacies In Times Of Disruption: Living And Learning During A Pandemic., Ashna Singh

The Journal of the Assembly for Expanded Perspectives on Learning

This review is structured around three central concepts that Williams develops throughout this book: affect, assemblages, and the connection between memory and identity. In Literacies in Times of Disruption: Living and Learning During a Pandemic, Williams focuses on the narratives of over thirty university students at the University of Louisville to examine how their literacy practices and emerging identities were influenced by physical, emotional, and structural crises.

Bringing Mindfulness Into First-Year Composition, Matt Lemas

The Journal of the Assembly for Expanded Perspectives on Learning

I first stumbled upon the relationship between mindfulness and writing sometime after college. I had been meditating for a few years—not perfectly, but enough to notice the way it softened the inner critic and procrastinator that usually accompanied me to the page.

James Moffett’S Basic Principles, Jonathan M. Marine, Stephen Lafer

The Journal of the Assembly for Expanded Perspectives on Learning

The tricky part about trying to distill James Moffett’s basic principles is that there are so many of them. In literature, the “major” poets are separated form the “minor” for a number of reasons, but one critical criteria is development; major poets have to develop across the span of their careers, either writing in new forms, or about and with new ideas or themes. Suffice to say, Moffett developed a great deal across his career, from a focus on pedagogy to a focus on spirituality and mindfulness along with increasing consideration of educational assessment and policy. Of course, I’m overgeneralizing …

Book Reviews Introduction: Is It Just Me?, Curtis Porter

The Journal of the Assembly for Expanded Perspectives on Learning

Each of the reviews in this issue of JAEPL focus on a book that was published long before this particular crisis. The books span very different academic fields and very different research methodologies. Yet each reviewer gives a glimpse of how the research behind each book emerged from lived challenges and illustrates how that research sheds light on the daily work and daily struggle that we collectively face.

Contributors: Jaepl - Volume 30, Wendy Ryden

The Journal of the Assembly for Expanded Perspectives on Learning

Contributors: JAEPL - Volume 30

Review: Cope, Emily M. Evangelical Writing In A Secular Imaginary: The Academic Writing Of Christian Undergraduates At A Public University., Kelly M. Sauskojus

The Journal of the Assembly for Expanded Perspectives on Learning

Emily Murphy Cope’s Evangelical Writing in a Secular Imaginary: The Academic Writing of Christian Undergraduates at a Public University (2024) empirically considers how evangelical students negotiate their identities in their academic writing.

Improving Data Quality In Survey Research: The Role Of Machine Learning In Handling Inconsistent Responses, Patrick Ndungutse

Information Systems and Quantitative Analysis Theses, Dissertations, and Student Creative Activity

This project aims to strengthen Gallup’s survey data preprocessing by integrating machine learning methods to detect inconsistent responses, complementing existing rule-based checks. The study benchmarks techniques such as Isolation Forest, clustering-based outlier scores, and autoencoders against current approaches to spot inconsistencies more efficiently and with reduced manual effort.

We will evaluate models using a dataset of survey responses previously flagged for inconsistency by Gallup, focusing on accuracy, coverage, and efficiency validated through expert review. The goal is to automate response classification into pass, review, or fail stages, aiming to reduce manual review time by about 25%, or 15 hours weekly, …

English Grammar Foundations, Salvatore Attardo

CHSSA Open Educational Resources (OER)

English Grammar for Undergraduate and Graduate students (Open Access)

International Panther Monthly, December 2025, University Of Northern Iowa. Office Of International Engagement.

Office of International Engagement newsletter

Contents:

--- From the Director's Desk
--- Fall 2025 with OIE
--- Student Spotlight
--- UNI's World Window
--- Did You Know?
--- Behind the Scenes
--- Find Connection at OIE
--- Get Involved

“The Goal Is To Help The Community”: Motivations And Experiences Of Diverse Families In A Special Education Parent Advocacy Program, Diana Cruz

Dissertations

The Individuals with Disabilities Education Act (IDEA, 2004) entitles parents of eligible students with disabilities to meaningful participation in their children’s educational planning. Despite this mandate, many parents encountered barriers that limited their ability to participate in special education processes. These challenges were amplified for culturally and linguistically diverse (CLD) families who often lacked the social and cultural capital needed to navigate the system (Trainor, 2010b). Culturally and linguistically diverse parents experience systemic barriers such as limited interpretation, discrimination, and cultural differences that restrict their engagement (Buren et al., 2018; Doucet, 2011; Harry, 2008; Kalyanpur et al., 2000; Sanders-Smith et …

Narrative Economics Of Sports Gambling Legalization: A Case Study Of The United States, Tyler John Hajek

Dissertations

Following the end of the Professional and Amateur Sports Protection Act in 2018, legalized sports betting has become prevalent in the United States (U.S.). Most states legalized the activities due to consumer interest and financial potential for tax revenue generation. The purpose of this study was to explore how legalized sports betting influenced tax revenues in the initial years of expanded adoption in the U.S. To address this purpose, the research questions were structured to uncover if states collectively benefited from the introduction of legalized sports betting, what states have financially benefitted from the implementation of legalized sports betting, and …

A Lineage Of Contemporary Jazz Violin, Tsu Hao Kuo

Dissertations

The development of jazz violin has always been multifaceted. Not only has it followed the evolution of jazz, but it has also established its own parallel genres. Since the swing era, the violin no longer remains a top choice for jazz musicians as opposed to early jazz musicians who often doubled on string instruments. Intriguingly, the decline of its popularity in larger ensembles did not inhibit the growth of the jazz violin. Not only did jazz violinists thrive in small jazz ensembles, but its distinct blend with other string music genres also reached styles beyond the common narrative of jazz …

Exploring The Integration Of Social And Emotional Learning In Chinese High School Music Courses, Yao Lu

Dissertations

Social and emotional learning has become increasingly important in recent years, especially after the COVID-19 pandemic. The mental health and emotional well-being of students have received unprecedented attention. However, in China, social and emotional learning is still a relatively new concept. High school students are in a critical period for self-identification and the development of values. Academic competition and peer comparisons have increased significantly, making them more in need of systematic, operational SEL support. Music, as a “natural carrier” of emotions, can externalize, identify, and regulate individual emotions, and can also cultivate empathy and relationship skills in collaborative settings such …

Reported Value Of Culturally Responsive Teaching Practices Of Virginia Agricultural Education Teachers, Natalie K. Ferand, Kendrick Spencer, Bradley Bowen

Journal of Research in Technical Careers

To address the increasing diversity in schools and the monolithic culture of teachers, researchers have called for pedagogies that reflect the diverse and pluralistic identities of students. While core academic areas have long adopted culturally relevant pedagogy, school-based agricultural education (SBAE) has lagged behind. This study aimed to determine the views of agricultural education teachers in Virginia on culturally responsive pedagogy dispositions and identify areas of professional development need. Teachers valued the differences among students and the communities in which their schools are located. However, results revealed a need for professional development in using the local community as a resource …

Online Experiential Learning In Career And Technical Education, Matthew Bornak

Journal of Research in Technical Careers

This scoping review investigates the integration of OEL into Career and Technical Education (CTE) programs. Using Arksey and O’Malley’s five-step scoping review framework, articles were identified through ERIC and Google Scholar and managed in Zotero. MAXQDA was used for coding, revealing thematic clusters related to modalities (synchronous, asynchronous, hybrid), technologies (LMS, AR/VR, simulation tools), and learner characteristics (nontraditional students, CTE-specific learning styles). The review highlights the conceptual anchors of Kolb’s Experiential Learning Theory, Carver et al.’s Experiential E-Learning Model, and Baasanjav’s online experiential design. Findings reveal that while OEL in CTE remains underexplored, it offers potential to increase accessibility, inclusivity, …