Digital Commons Network^™

The Patient Violence Framework, Laura Graham, Jennifer Bail

Biennial Convention (CONV)

Patient Violence against nurses is a widespread problem resulting in both emotional and physical injury to the nurse. Emergency Department (ED) nurses are at an increased risk due to the volume and variety of the patients they serve, and the general chaotic environment of the ED; however, little research has been done examining the characteristics of patients who offend and the physical environment of the ED where the event happened. The aim of this three-article dissertation was to develop a more thorough understanding of the personal attributes (endogenous) of the individual patient and external (exogenous) factors of the ED setting …

Electrochemical Sensors For In Situ Monitoring Of Reactive Species During Cold Atmospheric Plasma-Based Therapies, Jonathan Thomas, Suneel Kumar, Gagana Karkada, Julia Sutter, Kristina Pattison, Jason Rainone, Dhruv Patel, Shashank Madhavan, Fred Krebs, Francois Berthiaume, Vandana Miller, Katharina Stapelmann

Kimmel Cancer Center Faculty Papers

Cold atmospheric pressure plasma (CAP) is emerging as a clinically relevant therapy for dermatological conditions such as actinic keratosis, warts, and chronic wounds. However, these therapies lack strategies to monitor CAP delivery in situ and to ensure delivery of an effective CAP dose without unwanted toxicity. CAP acts as a therapeutic agent in these biomedical applications primarily (but not solely) through reactive oxygen and nitrogen species (RONS) generated at transiently high local concentrations. Here we demonstrate the use of bio-electrochemical sensors capable of real-time measurements of key CAP RONS: hydrogen peroxide and oxidation-reduction-potential (ORP). In in vitro scratch assays and …

Online Decision Mamba, Trenton W. Ruf

Dissertations and Theses

Online in-context reinforcement learning enhances offline-trained policies through online fine-tuning. We introduce Online Decision Mamba (ODM), an architecture that replaces the attention mechanism in Online Decision Transformers (ODT) with the Mamba module to improve long-context sequence modeling and overall RL performance. We performed in-depth evaluations on MuJoCo (OpenAI Gym) and Atari benchmarks, comparing ODM against state-of-the-art offline and online baselines—including Decision Mamba (DM) and ODT. Our results show that ODM achieves competitive or superior performance, with particularly robust gains when initial datasets lack expert demonstrations. In the Qbert Atari environment, ODM shows context-length sensitivity similar to offline DM; however, we …

In Their Own Voice: A Grounded Theory On Overcoming Internet Gaming Disorder, Jayson Carmona

Theses and Dissertations

Internet Gaming Disorder (IGD) is highly comorbid with depression, anxiety, sleep loss, lower productivity, and social isolation. The DSM-5 TR designates IGD as a condition for further study, however the ICD-11 has designed Gaming Disorder as a codified illness. While most studies look at IGD via a medical model lens focusing almost exclusively on symptomology, very little research explores the process of recovery in IGD. In this grounded theory inquiry, a theory of recovery from IGD is generated. Secondary internet data consisted of 113 posts on the subreddit /r/StopGaming on reddit.com. This resulted in 196 pages of data. Researcher used …

Commedia Accademica: An Autoethnographic Trajectory Of The Metacognitive Awakening And Critical Consciousness Development Of An Afro-Belizean American Male Math Teacher, Jason Garcia

LMU Theses and Dissertations

ABSTRACT Commedia Accademica: An Autoethnographic Trajectory of the Metacognitive Awakening and Critical Consciousness Development of an Afro-Belizean American Male Math Teacher by Jason Gregory Garcia The current autoethnography involved an epic poetic approach that sought to dismantle and disrupt an intricate network of the school-to-prison pipeline (McCarter, 2017) paradigms designed to subjugate African American male pupils in dysfunctional educational contexts. R. S. Smith (2025) stated, “Autoethnographies can use alternate forms of representation. . . . Because the study was an autoethnography, my reality, as researcher-participant, is seen through a unique window to the world” (p. 22). The literature suggests implementing …

Taking Proximate Causation Seriously: Moderating Felony Murder Injustice When The Killer Is On The Other Team, Maria T. Kolar

Seton Hall Law Review

No abstract provided.

Proceedings Of The 4th Research In High Performance Sports Colloquium (Hpsc 2025), Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

Culturally Responsive Assessment And Mtss Toolkit For Multilingual Learners, Morgan Kaltz

Masters Projects

English Learners (ELs) are often assessed using tools that fail to account for their linguistic and cultural backgrounds, leading to inaccurate conclusions about their academic abilities. This project addresses the problem of non–culturally responsive assessment by developing a framework and resources to help teachers design and implement assessments that more accurately reflect what multilingual learners know and can do. Rooted in the principles of Culturally Responsive Assessment (CRA) and aligned with the WIDA English Language Development Standards, this project supports educators in integrating language development with equitable instructional practices.

The project includes creating teacher-friendly tools, such as culturally responsive assessment …

Circulating Tumor Dna Refines Risk Stratification Of Neoadjuvant Therapy-Resistant Breast Tumors, Mark Jesus M Magbanua, Nayelis A Manon, Denise M Wolf, Samuel Rivero-Hinojosa, Ziad Ahmed, Rosalyn W Sayaman, Antony Tin, Derrick Renner, Ekaterina Kalashnikova, Lamorna Brown-Swigart, Gillian L Hirst, Christina Yau, Wen Li, Claudine Isaacs, Rebecca A Shatsky, Amy S Clark, Alexandra Zimmer, Amy L Delson, Angel Rodriguez, Minetta C Liu, Paula R Pohlmann, Laura J Esserman, Hope S Rugo, Angela Demichele, Laura Van 'T Veer

Faculty, Staff and Student Publications

Early-stage breast cancers resistant to neoadjuvant therapy (NAT), characterized by high residual cancer burden (RCB) after treatment, have an increased risk of metastatic recurrence. Here, we show that circulating tumor DNA (ctDNA) detected using a tumor-informed test (1) can improve risk stratification of patients with NAT-resistant tumors (RCB-II/RCB-III) and (2) predict response to NAT. Stratification using ctDNA status at pretreatment or post-NAT and ctDNA dynamics identified NAT-resistant tumors with a significantly decreased risk of metastatic recurrence. ctDNA clearance as early as week 3 across receptor subtypes predicted favorable responses to NAT, including immunotherapies. Interestingly, less than a fifth of patients …

Single Cell Spatial Profiling Of The Matrisome Identifies Region-Specific Adhesion And Signaling Networks In Glioblastoma, Arpan De, Santiago A Forero, Ali Pirani, John E Morales, Marisol De La Fuente-Granada, Sumod Sebastian, Jason T Huse, Leomar Y Ballester, Jeffrey S Weinberg, Frederick F Lang, Kadir C Akdemir, Joseph H Mccarty

Faculty, Staff and Student Publications

The human brain contains a milieu of extracellular matrix (ECM) components that promote normal development and physiology. ECM signaling pathways are often dysregulated in brain pathologies including the malignant cancer glioblastoma (GBM). Here, we used single-cell spatial transcriptomic platforms to map the expression of nearly 400 ECM genes in matching non-cancerous brain and GBM samples. At least four different GBM cell populations have been identified that show unique ECM expression profiles and spatial enrichment in distinct intratumor regions. Spatial mapping demonstrates largely non-overlapping expression signatures of ECM components in GBM stromal cell types, particularly in vascular endothelial cells and microglia/macrophages. …

A Review Of Bioactive Compounds Of Caesalpinia Sappan: Pre- And Post-Harvest Effect, Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly

Jurnal Kultivasi

Sappanwood (Caesalpinia sappan L.) is a shrub or small tree that thrives in tropical regions and has been widely distributed across various areas. It has long been used as a natural dye in textiles, cosmetics, and herbal beverages due to its content of various bioactive compounds. This literature review discusses the secondary metabolites in sappanwood, their health benefits, and strategies to enhance product quality through pre-harvest and post-harvest treatments. This literature review was conducted by searching for relevant journals on Google Scholar using relevant keywords. Sappanwood contains diverse secondary metabolites, including flavonoids, phenolics, anthraquinones, triterpenoids, steroids, alkaloids, and tannins, with …

Identifying Stable Parental Lines For Stripe Rust Resistance In Soft Red Winter Wheat, Ehsan Shakiba, David Moon

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Stripe rust, caused by Puccinia striiformis f. sp. tritici, continues to be a major challenge in soft red winter wheat (SRWW) production, especially in the southern United States. In this area, mild winters and wet springs frequently lead to early and severe disease outbreaks. Although many lines demonstrate resistance in a single season, that resistance often does not last across multiple years. For breeding programs, this variability makes it hard to identify truly reliable lines. In this study, we evaluated 111 SRWW breeding lines over three consecutive growing seasons (2021-2024) under artificial inoculation in field conditions in Fayetteville, Arkansas. Stripe …

A Systematic Review Of Teaching And Learning In The Context Of Arabic Diglossia, Hanada Taha Thomure, Haitham Taha, Taline Sabella, Rabab Saleh

All Works

Arabic is a diglossic language in which standard Arabic coexists with diverse spoken varieties, posing distinct challenges for language acquisition and instruction. Understanding how this context shapes bib_meiseles_1980 educational outcomes is essential for improving Arabic language teaching and learning. Following PRISMA guidelines, we searched eight education and social science databases, and relevant grey literature (1970–2021), screening 927 Arabic and English records and including 101 studies. Descriptive review synthesis identified five recurring themes: Diglossic distance, achievement gap, prestige and attitudes, policy, and exposure to Standard Arabic, including parental engagement. Recommendations relevant for educators, policymakers, and researchers include curriculum strategies include integrating …

Sustainable Polyaddition Path To Polyesters Via Catalytic Homocoupling Of Renewable Dicrotonate Monomers, Shabbir Asif, Mahsa Saeidi, Braden D. Pickle, Nicholas J. Tabbah, Michael L. Mcgraw

Chemistry & Biochemistry Faculty Publications and Presentations

The development of biorenewable polyhydroxyalkanoate (PHA) chemistry has generated interest in crotonate-based monomers as versatile building blocks. Crotonates can be obtained through the pyrolysis of PHAs, offering both a sustainable end-of-life pathway for PHAs and a renewable route to crotonate monomers. This study presents a new polyaddition-type step-growth polymerization of dicrotonates in which alkene-functionalized polyesters are synthesized using potassium tert-butoxide as a simple base catalyst. The reaction proceeds rapidly at room temperature, achieving >99% conversion within seconds and requiring no byproduct removal. The properties of the resulting polyesters can be tuned via the choice of bridging diol, and the materials …

Tgfbr2 Coordinates The Endometrial Response To Estrogen, Regulating Endometrial Hyperplasia And Fertility, Sydney E Parks, Suni Tang, Anna Catherine Unser, Ananya L Bhonsley, Eunbi M Chung, Peixin Jiang, Audrey Savolainen, Vanessa J Joseph, Dominique I Cope, Ramya P Masand, Renata Prunskaite-Hyyryläinen, Diana Monsivais

Faculty, Staff and Students Publications

Proper endometrial function is critical for establishing and maintaining healthy pregnancies, as well as preventing the pathogenesis of conditions such as endometrial hyperplasia and endometrial cancer. The TGFβ signaling pathway regulates key aspects of endometrial biology, although the direct effects of many individual receptors remain unstudied. In this study, we characterize the role of TGFβR2 within the endometrium using a progesterone receptor-cre conditional knock-out mouse model (Tgfbr2flox/flox;Pgrcre/+; “Tgfbr2 cKO”). We found that conditional deletion of TGFβR2 resulted in female infertility, endometrial hyperplasia, altered estrogen and progesterone response, and, only in bred females, reproductive tract …

Translational Ultrasound-Photoacoustic Imaging For Quantitative And Functional Cancer Diagnosis, Yixiao Lin

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cancer remains a leading cause of death worldwide, underscoring the need for imaging technologies that provide both structural and functional insights into cancer biology. Photoacoustic imaging (PAI), which detects ultrasonic signals generated by optical absorption, combines the strengths of both modalities, achieving optical contrast with ultrasonic resolution and depth. When co-registered with ultrasound (US), the hybrid US-PAI platform offers a unique combination of high-resolution anatomical and functional imaging that can improve cancer diagnosis, characterization, and treatment monitoring. This dissertation explores the clinical translation of US-PAI through innovations in imaging system design, computational analysis, and clinical validation across three major cancer …

Towards Fair Sequential Resource Allocation: Algorithmic Designs, Interventions, And Evaluations, Ashwin Kumar

McKelvey School of Engineering Graduate Student Theses & Dissertations

This thesis develops a comprehensive framework for fair sequential resource allocation in multi-agent systems where a centralized allocator coordinates actions under global feasibility constraints, while satisfying preferences of different agents. Ranging from ridesharing platforms and homelessness intervention programs to power grid management, such systems play a critical role in shaping access to essential resources. Yet, existing approaches to resource allocation often prioritize aggregate utility, leading to systematic inequities across individuals and groups, particularly in sequential settings where decisions unfold over time. To address this challenge, we introduce the Distributed Evaluation, Centralized Allocation (DECA) framework, which unifies a broad class of …

Integrating Molecular Electrochemical Insights And Device Engineering: Innovations In Organic Redox Flow Batteries, Methanol-Hydrogen Peroxide Fuel Cells, And Electrochemical Hydrogen Pumps, Kritika Sharma

McKelvey School of Engineering Graduate Student Theses & Dissertations

This dissertation presents an integrative study of molecular and device-level engineering strategies in advanced electrochemical energy technologies, addressing key challenges across organic redox flow batteries (ORFBs), direct methanol hydrogen peroxide fuel cells (DMHPFCs), and electrochemical hydrogen pumps (EHPs). First, the influence of electrolyte pH and salt anion chemistry on redox-active organic cations (BTMAP-Fc and BTMAP-Vi) is elucidated, identifying solvent reorganizational energy (λ) as a universal descriptor for optimal electrolyte selection in ORFBs. Detailed characterization reveals that low pH methanesulfonate or chloride counterions offer superior balance of kinetic and transport properties, facilitating efficient energy storage using earth-abundant elements. Second, a modified …

The Breakdown Of Neurovascular Barriers: Molecular Mechanisms Of Tight Junction Dysfunction, Sowmya Shree Gopal, Mandeep Kaur, Sophie Lanzkron, Amit K. Srivastava

Department of Medicine Faculty Papers

The central nervous system (CNS) relies on tightly regulated barriers to maintain homeostasis and protect neural tissue from blood-borne toxins, pathogens, and inflammatory mediators. Tight junctions (TJs) are critical components of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), forming selective paracellular seals that regulate molecular trafficking. These structures comprise transmembrane proteins and cytoplasmic scaffolding proteins, which anchor TJs to the actin cytoskeleton. The spatial organization and function of TJs are dynamically regulated by calcium-dependent signaling, phosphorylation events, and G-protein-mediated pathways, which govern their assembly, disassembly, and response to physiological and pathological stimuli. The integrity of TJ complexes is …

Synthesis And Characterization Of Copper Nanoparticles: A Laboratory Experiment For Undergraduate Physical Chemistry, Jonathan Batey, Deborah Okyere, Sarah York, Feng Wang, Jingy Chen

Chemistry & Biochemistry Faculty Publications and Presentations

Nonprecious metal nanoparticles have been the subject of intensive research, due to their potential applications in promoting sustainability. This integrated laboratory experiment is designed to provide undergraduate students with hands-on experience in synthesizing and characterizing nonprecious metal nanoparticles, specifically copper nanoparticles. The experiment consists of three sections, each tailored to teach a unique aspect of nanochemistry. Section 1 focuses on the air-free synthesis of copper nanoparticles using a solution-based method with an emphasis on understanding their plasmonic properties and how oxidation impacts them. Section 2 explores the quantitative analysis of copper, where students apply crystal field theory to understand the …

Accessing Cation And Anion Redox In Mixed-Valent One-Dimensional Iron-Chalcogenides, Na1.5fe1s2–Xsex(X = 0, 1, And 2), For Na-Ion Batteries, Santhoshkumar Sundaramoorthy, Milad Aghayi-Anaraki, Sutapa Bhattacharya, Amitava Choudhury

Chemistry Faculty Research & Creative Works

Sodium-ion batteries (NIBs) have attracted considerable attention as a cost-effective and sustainable alternative to lithium-ion batteries (LIBs), owing to the abundance and low cost of sodium resources. Here, we investigate previously reported mixed-valent (Fe^3+/2+) one-dimensional (1D) iron chalcogenides: Na1.5FeS2, its selenide analogue Na1.5FeSe2, and newly developed solid solution Na1.5FeSSe, focusing on their synthesis, structural characterization, and electrochemical performance in NIBs. While the full Fe²⁺sulfide version (NaFeS2) of the compound is explored in solid-state cells for its dual cation–anion redox mechanism, we reveal the effect of anion substitution on the electrochemical behavior of Na1.5FeS2–xSex(x = 0, 1, …

The Parent Caregiving Experience Of School-Aged Children With Cancer, Sofia Flowers

Biennial Convention (CONV)

In 2023, roughly 9,000 children less than 15 years of age were diagnosed with cancer in the United States. This suggests that approximately 18,000 parents were caring for a child newly diagnosed with cancer. In this informal caregiving role, parents’ roles double as both parent to their child and serving as their healthcare advocate. Studying the parent caregiving perspective can provide valuable insights for the professional health care team to guide their practice. The purpose of this project was to characterize the symptom management and caregiving experiences of parents of school-aged children diagnosed with cancer. The project was a secondary …

An Integrative Review Of Telehealth For Rural Veterans, Olivia Palczewski, Mary Clare K. Houlihan

Biennial Convention (CONV)

Introduction: Telehealth may be a sustainable healthcare delivery option for rural veterans as it allows for increased access to services and can lead to improved healthcare outcomes; however, the use of telehealth in this population is understudied.¹ Accordingly, the purpose of this integrative review was to analyze the barriers, outcomes, and effectiveness of telehealth for rural veterans. Levesque’s Patient-Centered Access to Health Care Framework guided this review as it considers supply-side and demand-side dimensions that influence how individuals access healthcare.²

Methods: A comprehensive literature search was performed in the PubMed and Scopus databases. The framework outlined in Whittemore …

Behavioral Health Interventions For Pediatric Acute Lymphoblastic Leukemia: A Scoping Review, Carolyn R. Bates, Sydney M. Gibson, Peter R. Johnson, Sarah L. Hunt, Patrick Dyjak, Courtney A. Gibson, Christina M. Sharkey, Kimberly L. Klages

Student Publications

Background: Acute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, with significant advancements in treatment leading to over 90% five-year event-free survival rates in developed countries. However, disruptions in health behaviors during treatment, such as diet, activity, and sleep, can negatively impact treatment tolerance and increase risks of late effects. This scoping review aimed to assess the breadth of existing behavioral health interventions designed to improve immediate and long-term health outcomes for children and adolescents receiving treatment for ALL.

Method: The review focused on behavioral interventions for children (ages 2-18 years) undergoing active treatment for ALL. We followed the …

To Jump Or Not To Jump: Comparing Effects Of Phenotypic Plasticity On The Visual Responses And Escape Behavior Of Locusts And Grasshoppers, Soumi Mitra, Saina Namazifard, David Mario Bellini, Alexis Leigh Sarne, Bidisha Halder, Margaret Ruth Eisenbrandt, Aliya Macknojia, Jiayi Luo, Samme Xie, Hojun Song, Chenghang Zong, Fabrizio Gabbiani, Richard Burkett Dewell

Faculty, Staff and Students Publications

Locusts exhibit remarkable phenotypic plasticity changing their appearance and behavior from solitary to gregarious when population density increases. These changes include morphological differences in the size and shape of brain regions, but little is known about plasticity within individual neurons and alterations in behavior not directly related to aggregation or swarming. We investigated looming escape behavior and the properties of a well-studied collision-detection neuron in gregarious and solitarious animals of three closely related species, the desert locust (Schistocerca gregaria), the Central American locust (S. piceifrons) and the American bird grasshopper (S. americana). For this neuron, the lobula giant movement detector …

International Consensus Guidelines For The Conduct And Reporting Of Car T-Cell Clinical Trials In Aml, Swati Naik, Richard Aplenc, Susanne H C Baumeister, Marco Becilli, Anand S Bhagwat, Challice L Bonifant, Lihua E Budde, Christopher D Chien, Kevin J Curran, Anthony F Daniyan, Alexandra Dreyzin, Rebecca A Gardner, Sara Ghorashian, Stephen Gottschalk, Laquisa C Hill, M Eric Kohler, Adam Lamble, Franco Locatelli, Maksim Mamonkin, Bilal Omer, Jae H Park, Concetta Quintarelli, Benedetta Rambaldi, Rebecca M Richards, David A Sallman, Tim Sauer, Nirali N Shah, Marion Subklewe, Corinne Summers, Sarah K Tasian, Naomi Taylor, Sarah Tettamanti, Michael R Verneris, M Paulina Velasquez, Saar I Gill

Faculty, Staff and Students Publications

Early clinical experience with the use of chimeric antigen receptor (CAR) T-cell therapies for patients with acute myeloid leukemia (AML) has been beset by high rates of toxicities and low rates of response. We convened an international workshop with the goal of bringing investigators in the field of AML-directed CAR T-cell therapy together to facilitate discussion of challenges and to brainstorm potential solutions. Based on discussions at the workshop, it was evident that (1) treating and targeting AML with CAR T cells is associated with unique clinical challenges, and (2) variability in clinical trial design, definitions of toxicities, correlative data …

Implementing The Nyu Electronic Patient Visit Assessment (Epva), Janet H Van Cleave, Abraham A Brody, Dena Schulman-Green, Kenneth S Hu, Zujun Li, Stephen B Johnson, Vincent J Major, Christopher E Lominska, Jessica R Bauman, Alexander N Hanania, Ghia V Tatlonghari, Marcely Tsikis, Brian L Egleston

Faculty, Staff and Students Publications

Background: Aggressive treatment with multimodal therapies such as surgery, chemotherapy, and radiation therapy has improved survival in head and neck cancer (HNC) but at a human cost of a substantial symptom burden and impact on quality of life. We developed the NYU Electronic Patient Visit Assessment (ePVA)© for HNC as a digital patient-reported symptom monitoring system that enables early symptom detection and real-time interventions at the point of care. With this study protocol, we aim to test the effectiveness of the ePVA in improving HNC outcomes in real-world settings and to identify implementation strategies optimizing its effectiveness.

Methods: We will …

Assessing Health Literacy In Somali Women Living In The United States With Hypertension, Tawanna Morris

Walden Dissertations and Doctoral Studies

Health literacy (HL) remains a critical public health concern, particularly among immigrant populations. This qualitative study explored how low health literacy relates to hypertension (HTN) management among Somali immigrant women. Low HL and chronic conditions such as HTN continue to affect this group disproportionately, emphasizing the need for targeted interventions. Guided by the Health Belief Model, this research examined Somali immigrant women’s perceptions of HL, how literacy levels influence hypertension management, and the barriers they encounter when managing their condition. Five Somali immigrant women who met the criteria participated in semi-structured interviews. All spoke English, were at least 18 years …

Elementary Teachers’ Perceptions Of A District Tutoring Program Focused On Improving Minoritized Students’ Proficiency, Asia M. Michael

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study is that 75% of minoritized students in Grades 3–5 are not meeting proficiency goals in math at a suburban New Jersey school district (NJSD, a pseudonym), which prompted the implementation of a high-impact tutoring program for all students. Grounded in Dewey’s theory of action, the purpose of this mixed-methods study was to explore upper elementary teachers’ perceptions of the high-impact tutoring program and its influence on minoritized students’ math proficiency at NJSD. Data were collected from 22 upper elementary teachers through an anonymous survey, including both quantitative and qualitative prompts. The quantitative …

Rare Epigenetic Alterations Are Conserved Across Hematopoietic Differentiation Stages After Mycobacterial Infection, Brandon T Tran, Pamela N Luna, Ruoqiong Cao, Duy T Le, Apoorva Thatavarty, Laure Maneix, Bailee N Kain, Scott Koh, Andre Catic, Katherine Y King

Faculty, Staff and Students Publications

Infection leads to durable cell-autonomous changes in hematopoietic stem and progenitor cells (HSPCs), resulting in production of innate immune cells with heightened immunity. The mechanisms underlying this phenomenon, termed central trained immunity, remain poorly understood. We hypothesized that infection induces histone modifications leading to changes in chromatin accessibility that are conserved during differentiation from HSPCs to myeloid progenitors and monocytes. We conducted genome-wide surveillance of histone marks H3K27ac and H3K4me3 and chromatin accessibility in hematopoietic stem cells, multipotent progenitor 3, granulocyte-monocyte progenitors, monocytes and macrophages of naïve and Mycobacterium avium infected mice. Interferon signaling pathways and related transcription factor binding …