Digital Commons Network^™

Effects Of Interventions For The Prevention And Management Of Maternal Anemia In The Advent Of The Covid-19 Pandemic: Systematic Review And Meta-Analysis, John Kyalo Muthuka Dr., Diana Kageni Mbari-Fondo, Francis Muchiri Wambura, Kelly Oluoch, Japheth Mativo Nzioki, Nabaweesi Rosemary Dr

Faculty Publications

No abstract provided.

“Were The Creation Days Twenty-Four-Hour Days Or Indefinite Periods Of Time?”, Jiri Moskala

Faculty Publications

No abstract provided.

Using Generative Models For Data Augmentation In Medical Imaging, Nilesh Kumar

Theses

Obtaining large amounts of labelled data in medical imaging is hindered by issues like privacy and cost, therefore limiting the gains that can be achieved from Deep Neural Networks (DNNs). A lot of work has shown data augmentation to be an effective strategy for expanding training data leading to more robust models. However, the lack of data is not always uniform across datasets e.g., some classes in a dataset may be underrepresented. This is particularly problematic because the overall good performance of a model on a dataset can easily mask the under-performance of underrepresented classes or instances. Naively employing data …

Rondo: A Minimal Single Page Application For Digital Exhibits, Nick Szydlowski

Faculty Research, Scholarly, and Creative Activity

Minimal computing is a promising conceptual framework for digital humanities infrastructure, but the static site architecture most commonly associated with minimal computing can present a steep learning curve, particularly in a workshop or classroom context. This article introduces Rondo, a new minimal framework for digital exhibits which requires no software installation or command line interaction. Rondo differentiates itself from static site tools by adopting a single page application architecture with data stored in a Google Sheet, but it includes tools to disconnect from Google Sheets and create a static site with no external dependencies. Rondo’s reliance on Google Sheets reflects …

Bridging Sql Mastery And Career Confidence For Undergraduate Students Through Simulated Job Interviews, Dailin Zheng, Yu Chen, Leslie J. Albert

Faculty Research, Scholarly, and Creative Activity

Employers increasingly prioritize candidates who can solve real-world Structured Query Language (SQL) problems, particularly during technical interviews. However, many undergraduate students feel underprepared for these interviews because they have not engaged in the deep learning needed to apply SQL concepts confidently. Additionally, students often fail to recognize the career relevance of SQL skills. This Teaching Tip introduces an immersive SQL lesson designed to bridge the gap between conceptual learning and practical application. The lesson includes a mock SQL technical interview, where students apply their knowledge to solve real-world business problems, class discussions on SQL-related careers, and a post-interview debrief to …

Is There A Future For The Missiological Study Of Worldview?, Paulo Oliveira

Faculty Publications

No abstract provided.

"17 Going On 23": Sentencing Young People To Life In Canada, Debra Parkes

All Faculty Publications

This paper analyzes reported Canadian cases from 2008 to 2022 in which young people were sentenced for murder. It shows that, at least in these reported decisions, sentencing young people as adults for murder is not rare. The Crown routinely seeks life sentences for young people and the court orders them in the vast majority of cases in which they are sought. Life sentences for young people have become normalized and expected in murder cases, rather than exceptional. This paper delves into the case law to get a better picture of why and how this is happening.

Old Habits Die Hard: Precedent, Psychology, And The Admissibility Of Forensic Evidence, Sara Gordon

All Faculty Publications

Forensic evidence, long considered a cornerstone of criminal justice, has faced increasing scrutiny as recent studies and reports expose significant flaws in its scientific foundation. Techniques such as latent fingerprint analysis, microscopic hair comparison, and ballistics matching, which had been widely accepted for decades, are now being challenged for their lack of empirical validation. Reports by the National Research Council and the President’s Council of Advisors on Science and Technology have highlighted the deficiencies in these forensic methods, calling into question their reliability and the weight they are given in courtrooms. Yet despite the growing acknowledgement of widespread issues affecting …

Streaming, Copyright And Creators: A Canadian Perspective, Graham Reynolds

All Faculty Publications

This paper will provide an introduction to streaming and copyright in Canada. It will proceed in five parts. Following this introduction, Part 2 of this paper will define streaming, discuss some of the benefits that flow from the widespread use of streaming services, and outline the extent to which streaming technologies are in use in Canada today. In so doing, this paper will distinguish between three types of streaming services: streaming services that secure authorization from rights-holders before making content available; streaming services that rely on technological measures or liability exemptions in order to host content in a non-infringing manner; …

Binding Rights: Contractual Federalism And The Right To Housing In Canada, Alexandra Flynn

All Faculty Publications

Canada’s housing crisis continues to deepen, exacerbated by constitutional fragmentation and intergovernmental reluctance to implement human rights-based housing policy. While the federal National Housing Strategy Act recognizes housing as a human right, its application is limited and its legal force is limited to the federal level, leaving provinces and municipalities unbound. This article argues that contract law – particularly conditional funding agreements between the federal government and subnational actors – can serve as a pragmatic and legally coherent mechanism to bind municipalities to housing obligations, including the recognition of housing as a human right. Drawing on the Canada Health Act …

Evaluation Of Methotrexate Pharmacogenomic Variation To Predict Acute Neurotoxicity In Children With Acute Lymphoblastic Leukemia, Rachel D Harris, Olga A Taylor, M Monica Gramatges, Amy E Hughes, Mark Zobeck, Sandi Pruitt, M Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Ashley Choi, Yuu Ohno, Melissa A Richard, Alanna C Morrison, Han Chen, Bing Yu, Philip J Lupo, Karen Rabin, Michael E Scheurer, Austin L Brown

Faculty, Staff and Students Publications

BACKGROUND: Methotrexate is an important component of curative therapy in childhood acute lymphoblastic leukemia (ALL), but the role of genetic variation influencing methotrexate clearance and transport in toxicity susceptibility in children with ALL is not well established. Therefore, we evaluated the association between suspected methotrexate pharmacogenomic variants and methotrexate-related neurotoxicity.

METHODS: This study included children (aged 2-20 years) diagnosed with ALL (2005-2019) at six treatment centers in the southwest United States. Clinical information was abstracted from medical records. Suspected neurotoxic events occurring within 21 days of intravenous and/or intrathecal methotrexate delivered between the end of induction and start of maintenance …

Mutations In Retinal Cyclic Nucleotide-Gated Channels Identified In Familial Cases Of Inherited Retinal Dystrophies From Pakistan, Zainab Akhtar, Kiran Afshan, Yumei Li, Sumaira Altaf, Aleesha Asghar, Ume Sughra, Wajid Ali Khan, Haiba Kaul, Rui Chen, Sabika Firasat

Faculty, Staff and Students Publications

Purpose: Cyclic nucleotide-gated (CNG) channels are ligand-gated ion channels that transduce light signals into electrical signals in the retinal photoreceptors. Pathogenic variants in CNG channel genes are reported to cause inherited retinal dystrophies (IRDs). The current study used targeted panel sequencing to describe the mutational spectrum of CNG channel genes in familial cases of IRDs from eight consanguineous Pakistani families.

Methods: The current study included consanguineous Pakistani families with at least two affected members. DNA was extracted from whole blood samples by the phenol-chloroform method. Two affected members from each family were initially analyzed using targeted panel sequencing of 344 …

Nanoparticle Contrast-Enhanced Computed Tomography Of Sporadic Aortic Aneurysm And Dissection: Effect Of Nanoparticle Size And Contrast Agent Dose, Laxman Devkota, Chen Zhang, Deborah Vela, Poonam Sarkar, Prajwal Bhandari, Zbigniew Starosolski, Renuka Menon, Dianna M Milewicz, Ying H Shen, Scott A Lemaire, Ketan B Ghaghada

Faculty, Staff and Students Publications

Background: Aortopathies, such as aortic aneurysm and dissection (AAD), are associated with enhanced aortic wall permeability and endothelial dysfunction. We previously demonstrated that nanoparticle contrast-enhanced computed tomography (nCECT), which detects enhanced aortic wall permeability, could enable non-invasive detection of early AAD before its progresses to fatal aortic rupture. This study investigated the effect of nanoparticle contrast agent (NPCA) size and dose on detection of aortopathy by nCECT.

Methods: In vivo studies were performed in a mouse model of sporadic AAD induced by challenging animals with high fat diet (5 weeks) and angiotensin II infusion (last one week). The effects …

Structural Dynamics And Binding Of Caenorhabditis Elegans Lifespan-Extending Lipid Binding Protein-3 To Polyunsaturated Fatty Acids, André R Cuevas, Matthew C Tillman, Meng C Wang, Eric A Ortlund

Faculty, Staff and Students Publications

Intracellular lipid binding proteins (iLBPs) play crucial roles in lipid transport and cellular metabolism across the animal kingdom. Recently, a fat‐to‐neuron axis was described in Caenorhabditis elegans, in which lysosomal activity in the fat liberates polyunsaturated fatty acids (PUFAs) that signal to neurons and extend lifespan with durable fecundity. In this study, we investigate the structure and binding mechanisms of a lifespan‐extending lipid chaperone, lipid binding protein‐3 (LBP‐3), which shuttles dihomo‐γ‐linolenic (DGLA) acid from intestinal fat to neurons. We present the first high‐resolution crystal structure of LBP‐3, which reveals a classic iLBP fold with an unexpected and unique homodimeric …

Incidence And Outcomes Of Hospitalized Acute Ischemic Stroke Patients With Subsequent St-Segment-Elevation Myocardial Infarction, Arhum Mahmood, Song Peng Ang, Yusuf Kamran Qadeer, Hafeez Ul Hassan Virk, Jonathan Alan Tangsrivimol, Iqra Riaz, Zhen Wang, Mahboob Alam, Markus Strauss, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Background: Patients admitted with acute ischemic stroke (AIS) may experience accompanying acute ST-Segment myocardial infarction after AIS. The cardiovascular risks, incidence, complications, and outcomes of acute STEMI in patients hospitalized with AIS remains underexplored.

Methods: We evaluated 2,804,819 patients that presented with AIS who were listed in the National Inpatient Sample from 2016 to 2021. AIS and STEMI were defined according to the ICD-10 Diagnostic Codes. Patients with Non-STEMI were excluded. The risk of specific complications and outcomes were expressed as percentages. Multivariable logistic regression analysis was used to examine the association of STEMI with a primary outcome of mortality …

Testosterone Plus Lifestyle Therapy Improves Skeletal Muscle Glycolysis In Older Men With Obesity And Hypogonadism, Viola Viola, Marlene Aguilar, Maria Liza Duremdes Nava, Alessandra Celli, Reina Armamento-Villareal, Yoann Barnouin, Nicola Napoli, Nagireeddy Putluri, Clifford Qualls, Dennis T Villareal

Faculty, Staff and Students Publications

Objective: Weight loss in older men with obesity and hypogonadism accelerates musculoskeletal decline, yet the underlying metabolic mechanisms remain unclear. Testosterone replacement therapy (TRT), when added to lifestyle therapy (LT), mitigates this decline, but its metabolic basis has not been defined. We examined skeletal muscle metabolomic adaptations to LT with or without TRT, focusing on glycolysis, the pentose phosphate pathway (PPP), the tricarboxylic acid (TCA) cycle, and carnitine metabolism to identify dominant pathways of metabolic adaptation.

Design: Randomized, double-blind, placebo-controlled trial (LITROS).

Methods: Eighty-three men aged 65 years or older with obesity (BMI ≥30 kg/m2), hypogonadism (testosterone < 10.4 nmol/L), and frailty (Physical Performance Test score ≤31) were randomized to 26 weeks of LT plus TRT (LT+TRT) or LT plus placebo (LT+Pbo). A metabolomic substudy was performed in 44 participants, who underwent serial biopsies of the vastus lateralis for targeted LC-MS/MS analysis of intermediates in glycolysis, PPP, TCA cycle, and carnitine metabolism.

Results: Among the …

Clues To Transcription/Replication Collision-Induced Dna Damage: It Was Rnap, In The Chromosome, With The Fork, Matthew B Cooke, Christophe Herman, Priya Sivaramakrishnan

Faculty, Staff and Students Publications

DNA replication and RNA transcription processes compete for the same DNA template and, thus, frequently collide. These transcription-replication collisions are thought to lead to genomic instability, which places a selective pressure on organisms to avoid them. Here, we review the predisposing causes, molecular mechanisms, and downstream consequences of transcription-replication collisions (TRCs) with a strong emphasis on prokaryotic model systems, before contrasting prokaryotic findings with cases in eukaryotic systems. Current research points to genomic structure as the primary determinant of steady-state TRC levels and RNA polymerase regulation as the primary inducer of excess TRCs. We review the proposed mechanisms of TRC-induced …

Folate Receptor Β Performs An Immune Checkpoint Function In Activated Macrophages, Fenghua Zhang, Md Yusuf Al-Amin, Sagar Utturkar, Rina Jiang, Gregory Cresswell, Rami Alfar, Ian Ophaug-Johansen, Gabriel Bachman, Madduri Srinivasarao, Richard Finnell, Amaya Puig-Kröger, Timothy Ratliff, Philip S Low

Faculty, Staff and Students Publications

Monocytes and macrophages are sentinels of the immune system that distinguish themselves from other cells by expressing the beta isoform of the folate receptor (FRβ). Because FRβ does not bind folate until the monocyte/macrophage is exposed to immunosuppressive cytokines, the question naturally arose whether FRβ might also perform an immune-related function. To examine this matter, we compared the properties of wild type (WT) and FRβ knockout mice. We observe that FRβ knockout (KO) mice display autoimmune symptoms that can include alopecia, enlarged spleens, and dermatitis, despite having normal cellular folate levels. We further demonstrate that syngeneic tumors (TRAMP C2, MC38) …

The Enigmatic Pianist Arthur Friedheim: A Revised Biography And Study Of His Training, Performing, Writings, Teaching And Editions, Nicholas Mark Williams

Theses: Doctorates and Masters

Arthur Friedheim (1859–1932) was one of the most notable pianists of the late nineteenth century, best remembered as a devoted pupil and disciple of Franz Liszt (1811–1886). Following Friedheim’s Leipzig debut in 1884, Liszt predicted that his young pupil “would yet become the greatest piano virtuoso of the age.” During his lifetime, Friedheim would be compared with such pianistic giants as Carl Tausig (1841–1871), Moriz Rosenthal (1862–1946) and Ferruccio Busoni (1866–1924). Yet his posthumous reception, based on a few surviving recordings and a small number of written sources, has tended to cast doubt on his importance. Some critics disparagingly dismissed …

Optimal Bag Valve Mask Ventilation Efficacy Of Smart Bag Ventilation Compared To Traditional Adult And Paediatric Bag Valve Ventilation During Cardiopulmonary Resuscitation, Ian Dawson

Theses: Doctorates and Masters

Background: Out-of-Hospital Cardiac Arrest (OHCA) is one of the world’s leading causes of mortality. Survival rates are low, ranging from 3.1–20.4% internationally. The most effective oxygenation method for patients during pre-hospital cardiac arrest is ventilating using a self- inflating Bag-Valve-Mask (BVM). Yet, extensive research has identified a lack of compliance with ventilator guidelines during OHCA cardiopulmonary resuscitation (CPR). As a result, clinicians often ventilate patients too aggressively using the BVM, delivering breaths excessively higher than the International Liaison Committee on Resuscitation (ILCOR) recommended rate of 10 breaths per minute (BPM). Hyperventilation can lead to complications such as aspiration, barotrauma, and …

Athlete Monitoring And Training Modification Decision-Making: Insights From High-Level Endurance Sports Coaches, Wouter Piet Timmerman

Theses: Doctorates and Masters

Athlete monitoring technology has proliferated in the last decades. However, much of what is known about athlete monitoring tends to come from unpublished personal experiences and anecdotal information. In the last decade, considerable athlete monitoring research has been conducted, leading to multiple reviews and consensus statements mainly on athlete monitoring tools and methods. Recognising that athlete monitoring is a human-driven process, typically with the coach as the decision-maker, it is imperative to study coaches given their extensive knowledge and expertise. The overall aim of the thesis was to gain insights into why and how high-level endurance sports coaches use athlete …

Ethno-Psychometry: The Measurement Of Personality In Mexico, Rolando Diaz-Loving

Online Readings in Psychology and Culture

Following in the tradition of ethno-psychological research proposed by Diaz-Guerrero (1986, 1989, 1993, 1994, 1995), this manuscript delineates the process toward obtaining statistically and conceptually valid and reliable personality measures, that at the same time are also culturally relevant and sensitive to the Mexican culture. The methods and construct development for the creation of multidimensional measures of achievement orientation, empathy, locus of control, assertiveness, masculinity, femininity, and self-concept are presented. Further information on the specific characteristics of measures, their construct and convergent, divergent, and predictive validity can be found in Diaz-Loving (2019).

Investigation Of Under-Frequency Load Shedding Prevention Of Isolated Medium-Sized Power Systems Using Energy Storage, Dilan Indoopa Manamperi

Theses: Doctorates and Masters

Due to the rapid uptake of distributed photovoltaic generation, the visible load to transmission operators in distribution feeders is reducing. Traditional load-shedding schemes are facing challenges due to this low-load situation. The required amount of load reduction cannot be achieved with the same load-shedding scheme as before. In some situations, with reverse power flows, load shedding can further increase the generation reduction. On the other hand, increased Rate of Change of Frequency (RoCoF) due to low inertia can result in false activation of under-frequency load shedding (UFLS) relays. These challenges can cause a serious problem with the power system security. …

Machine Learning For Computer-Aided Diagnostics From Complex Medical Images, Afsah Saleem

Theses: Doctorates and Masters

Machine learning has significantly transformed medical image analysis in the current age of artificial intelligence offering vast potential in improving disease diagnosis and management. Cardiovascular diseases (CVDs) are among the leading cause of global mortality, emphasizing the need for early detection for effective intervention and prevention. Abdominal Aortic Calcification (AAC) is an early indicator and contributor to Atherosclerotic Cardiovascular Diseases (ASCVDs) and is commonly assessed through imaging modalities such as computed tomography (CT), X-rays, and Dual-energy X-ray Absorptiometry (DXA). Among these, lateral spine DXA scans, commonly used for osteoporosis screening, offer a cost-effective and low-radiation opportunity for opportunistic CVD risk …

Modelling The Impacts Of Recreational Catch-And-Release Variability On Fish Stock Dynamics, Brett Crisafulli

Theses: Doctorates and Masters

Recreational fisheries often lack sufficient data for robust stock assessments, and post-release mortality (PRM) of discarded fish, particularly demersal species, poses a significant threat to sustainability. Because demersal fish often experience higher PRM (often due to barotrauma and stress), the substantial global interest in their recreational fisheries (e.g., Australia, Gulf of Mexico, Western Baltic Sea) raises conservation concerns. This study employs three distinct modelling approaches, applied to four reef-dwelling demersal species, to support effective recreational fisheries management by addressing data uncertainty, unintended consequences of management changes, and PRM effects. Specifically, this thesis (1) evaluates variability in average weights of recreationally-caught …

Early, Standardised, And Precise Treatment Of Copd Exacerbations And Covid-19, Sanjay Ramakrishnan

Theses: Doctorates and Masters

Background: Background Chronic Obstructive Pulmonary Disease (COPD) is a common chronic condition causing significant morbidity and mortality. Patients with COPD report sudden episodes of deteriorating respiratory symptoms called exacerbations, often presumed to be precipitated by infections. COPD is in the top 5 causes of death globally. COPD exacerbations drive a large proportion of these deaths. Despite this, there is no standardised model of care for the sickest patients who need hospitalisations for exacerbations. Meanwhile, treatment for COPD exacerbations continues to be guided by symptoms, instead of underlying biology. Most patients are treated with unnecessary and harmful systemic corticosteroids. During the …

Family Members’ Experiences Of Post-Cardiac Surgery Delirium In The Intensive Care Unit: A Narrative Inquiry, Amber Coral Mclean

Theses: Doctorates and Masters

Aim: This study explores delirium in the intensive care unit (ICU) following cardiac surgery from the perspective of family members.

Background: Delirium is a common complication affecting 28-52% of people following cardiac surgery in the ICU, which can lead to distress for both the person and their family members. While research has been conducted on clinical outcomes of family involvement in delirium care, there is a lack of understanding of how delirium impacts the family members themselves. This study seeks to provide detailed narrative accounts of families’ experience of witnessing delirium in their loved one following cardiac surgery in the …

Numerical Methodologies For The Analysis Of Horizontal-Axis Floating Offshore Wind Turbines (F-Hawts): A State-Of-The-Art Review, Naghmeh Akbari Zadeh, Peter Ryan, David M. Kennedy, Fergal O’Rourke

Research Outputs: 2025-Present

In recent decades, wind turbine installations have become a popular option to meet the world’s growing demand for energy. Both onshore and offshore wind turbines form pivotal components of the electricity sector. Onshore wind energy is now a mature technology, with significant experience gained by wind farm developers and operators over the last couple of decades. However, as a more recent enterprise, the offshore wind industry still requires significantly more development before the technologies and operations reach maturity. To date, floating platforms at sea have been utilised extensively for the oil and gas industry. While a lot of the expertise …

Factors Associated With Contraceptive Discontinuation Among Women In The U.S., Moradi Aljadani

Electronic Theses and Dissertations 2020 - Present

Background: Contraceptive discontinuation is a significant public health concern in the United States, contributing to unintended pregnancies and associated health, social, and economic consequences. Despite the availability of a wide range of contraceptive methods, many women discontinue use prematurely due to a variety of personal, social, cultural, and systemic factors. However, limited research has comprehensively examined these factors at the national level, particularly within a theoretical framework that captures the multidimensional influences on contraceptive decision-making. Objective: This study aimed to assess the factors associated with contraceptive method discontinuation among women in the U.S, guided by Ray’s Theory f …

“Thank You For Hearing Me”: Listening To Stories Of Linguicism, Caroline Asher Webb

Electronic Theses and Dissertations 2020 - Present

This dissertation examines the effects of linguicism on nonnative speakers of English who are currently studying in higher education in the United States or other English-dominant countries. Linguicism, also called linguistic discrimination, others and discriminates against people based on their oral or written language use. Rooted in master narratives of Standard English, monolingualism, and the native speaker, linguicism, unlike other forms of discrimination, such as gender or racial discrimination, is subtle and unmarked, thus permeating the consciousness of even the most well-intentioned of people.

Using a Critical Race Theory framework, the present study utilized a storytelling methodology to gather first-hand …