Digital Commons Network^™

Study On The Role Of Shenfu Injection In Mediating Ferroptosis Through The Akt/Gsk-3Β/Nrf2 Pathway In Yang-Deficient Chronic Heart Failure, Xiaojie Chen, Jiayun Guo, Bing Lin, Huamin Wang, Ziyu Lu, Bayi Liu

Turkish Journal of Biology

Background/aim: The present study investigates the role of Shenfu injection in the treatment of yang-deficient chronic heart failure (CHF). Materials and methods: Sprague-Dawley (SD) rats were modeled for yang-deficient CHF by abdominal aortic coarctation. Echocardiography was performed to detect changes in cardiac function, and serum N-terminal B-type natriuretic peptide proteins (NT-proBNP), cardiac troponin I (cTnI), and ferroptosis-related factors were measured using ELISA kits. Pathological changes in cardiac tissues were observed through hematoxylin-eosin (HE) and Masson’ trichrome staining, cardiomyocyte apoptosis was measured by TUNEL staining, and reactive oxygen species (ROS) production was determined through dihydroethidium (DHE) staining. The expression of nuclear …

Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng

Turkish Journal of Biology

Background/aim: Fibroblast Growth Factor Receptor (FGFR) gene fusions are recognized as pivotal oncogenic drivers, contributing to cancer initiation and progression across diverse malignancies. These fusions often represent significant therapeutic targets, particularly in challenging malignancies like cholangiocarcinoma. This study aimed to characterize the novel FGFR2::SHTN1 fusion, identify it as a de novo chimeric protein, and elucidate its precise oncogenic mechanism. Materials and methods: FGFR2::SHTN1 fusions were identified via cancer genomics databases and modeled using AlphaFold and HADDOCK. SHTN1 variants were expressed in Neuro-2a cells for coimmunoprecipitation, purification, and native polyacrylamide gel electrophoresis to assess oligomerization. Structural modeling included membrane embedding with …

Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak

Turkish Journal of Biology

Background/aim: This study aimed to investigate the phenotypic resistance and distribution of efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. isolated from dairy and meat samples. Antimicrobial resistance in foodborne bacteria increases with antibiotic exposure and biocides, particularly through efflux mechanisms. Thus, monitoring potential genetic reservoirs in the food chain is very important. Materials and methods: A total of 132 dairy and meat samples were collected for the study, and Staphylococcus spp. were isolated using Mannitol salt phenol red agar. Antimicrobial susceptibility was evaluated using the Clinical and Laboratory Standards Institute’s microdilution method. Twenty-six resistant isolates were identified by 16S …

นัยของพันธกรณีตามความตกลงระหว่างประเทศว่าด้วยการลงทุนต่อการทำหน้าที่ของศาลในการกำกับดูแลการอนุญาโตตุลาการทางพาณิชย์ระหว่างประเทศ (Implications Of International Investment Agreement’S Obligations On A Supervisory Function Of Domestic Courts Over International Commercial Arbitration), Chotika Wittayawarakul

Chulalongkorn University Law Journal

บทความวิจัยนี้ศึกษาพันธกรณีภายใต้ความตกลงระหว่างประเทศว่าด้วยการลงทุนที่เกี่ยวข้องกับการกระทำทางตุลาการ และแนวคำชี้ขาดของคณะอนุญาโตตุลาการที่ระงับข้อพิพาทระหว่างรัฐกับนักลงทุน เพื่อวิเคราะห์นัยของพันธกรณีของรัฐตามความตกลงดังกล่าวต่อการทำหน้าที่ของศาลโดยเฉพาะอย่างยิ่งในการกำกับดูแลการอนุญาโต ตุลาการทางพาณิชย์ มีหลายคดีที่นักลงทุนกล่าวหาว่าการกระทำของศาลในการกำกับดูแลการอนุญาโตตุลาการทางพาณิชย์ละเมิดพันธกรณีของรัฐตามความตกลงระหว่างประเทศว่าด้วยการลงทุน ซึ่งทำให้คณะอนุญาโตตุลาการต้องทบทวนคำพิพากษาและคำสั่งของศาลภายใน จากการศึกษาพบว่าคณะอนุญาโตตุลาการมีแนวโน้มที่จะยอมรับดุลพินิจของศาลภายใน กรณีที่ถือว่าการกระทำของศาลเป็นการละเมิดพันธกรณีตามความตกลงระหว่างประเทศว่าด้วยการลงทุนต้องเป็นกรณีที่การกระทำของศาลมีความบกพร่องอย่างร้ายแรงซึ่งพิจารณาจากมาตรฐานระหว่างประเทศ อนุสัญญาว่าด้วยการยอมรับนับถือและการบังคับตามคำชี้ขาดอนุญาโตตุลาการต่างประเทศ ค.ศ. 1958 มีบทบาทสำคัญในการพิจารณาความรับผิดของรัฐตามความตกลงระหว่างประเทศว่าด้วยการลงทุน

Strengthening Homoeopathy With Standards: The Bis Initiative, Raj K Manchanda, Kumar Vivekanand, Daisy Katarmal

Indian Journal of Research in Homoeopathy

NA

Buchanan Named Aatf Teacher Of The Year, Communications And Marketing

Campus News Archive

No abstract provided.

Many Hands Make Stronger Work: Building Cross-Institutional Undergraduate Research Experiences Using Universal Design For Learning, Stephen Podowitz, Abigail Graham, Madison E. Greene, Sarah R. Johnson, Katherine Leonard, Margaret Vander Sys, Mariel A. Pfeifer

College of Life Sciences Faculty Papers

Designing an undergraduate research experience in which all team members can meaningfully contribute and experience growth can be challenging, especially for virtual teams working across institutions. For two years, the authors worked remotely as a team that included several undergraduate researchers in a highly involved research project. Through the partnership, the two principal investigators on the project were able to involve more undergraduates in research than they could individually, using a mentoring model that drew on Universal Design for Learning (UDL) principles to ensure students had opportunities for intellectual involvement in the research process. By working as an integrated team, …

Research Highlights, Kusum Lata, Ekta Agrawal

Indian Journal of Research in Homoeopathy

NA

Guiding Principles For Teaching About Genocide And Other Difficult Pasts, Kerry E. Whigham

Genocide Studies and Prevention: An International Journal

This article outlines guiding principles for teaching “difficult pasts”—episodes of large-scale, identity-based violence such as genocide, crimes against humanity, colonialism, and enslavement—in ways that promote peace, human rights, and the prevention of future atrocities. Drawing from the fields of Holocaust and Genocide Education (HGE), Global Citizenship Education (GCED), Peace Education (PE), and Human Rights Education (HRE), it argues that instruction should move beyond the memorization of historical facts toward developing students’ socio-emotional and behavioral capacities to recognize and resist processes of othering, discrimination, and violence. The brief presents three main areas of guidance: curricular content, emphasizing conceptual understanding over rote …

Arts & Literature: Impotent Witness: A Tale Of Two Genocides, And Counting, Lisa M. Simeone

Genocide Studies and Prevention: An International Journal

This essay draws on memory, ethnography, and theory to consider a scholar’s personal and political responsibility as witness.

Perspectives On Implementing Environmentally Sustainable Practices In Cataract Surgeries: Interviews Of Administrative And Frontline Healthcare Workers, Daniel Parra, Brooke Sherry, Emma Pak, Lauren Taylor, Erin S. Rogers, Sarah E. Hochman, Maria De Los Angeles Ramos Cadena, Joel S. Schuman, Christina R. Prescott, Cassandra L. Thiel

Wills Eye Hospital Papers

BACKGROUND: Healthcare is responsible for 8.5% of greenhouse gas emission in the United States. Physicians are becoming increasingly concerned about the climate crisis, particularly in the field of ophthalmology where there is a growing body of literature related to sustainability. Although emissions of cataracts surgery, one of the most performed surgical procedures in the world, have been quantified, modifications to practice have yet to be made. This study aims to uplift the perspectives of a diverse set of healthcare workers on implementing environmentally sustainable practices in the cataract surgery setting.

METHODS: 16 semi-structured interviews were conducted with professionals working in …

Dental Students' Perceptions Of Patient Safety: A Cross-Sectional Study Using The Traditional Chinese Version Of The Attitudes To Patient Safety Questionnaire, Chen-Yi Lee, Ju-Hui Wu, Yu-Chih Lin, Shu-Yuan Lin

Journal of Medical Education

Objectives: This study aimed to examine the psychometric properties of the traditional Chinese version of the Attitudes to Patient Safety Questionnaire (APSQ-T) in a Taiwanese population (Study 1) and investigate dental students' perceptions of patient safety, identify their educational needs, and correlate these aspects to improve the curriculum (Study 2). Methods: Study 1 conducted a cross-sectional study using convenience sampling at a medical university in Taiwan. A total of 223 participants from the fields of dentistry, oral hygiene, nursing, and medicine were recruited to complete an anonymous survey for the validation of the APSQ-T. In Study 2, data collected from …

Digital Zakat And Islamic Fintech: A Bibliometric Analysis Of Global Research Trends And Collaboration Networks (2012–2025), Muhamad Dupi, Fauziyah Adzimatinur

Journal Of Middle East and Islamic Studies

This paper examines global research trends, collaborative networks, and prevailing themes in digital zakat and Islamic fintech studies published from 2012 to 2025. We retrieved a total of 194 Scopus-indexed publications using bibliometric methods on September 23, 2025, and analyzed them using VOSviewer version 1.6.20. The analysis set a minimum occurrence threshold of 5 for keywords and a minimum citation threshold of 10 for documents. The results indicate that the number of publications has been steadily rising since 2017, with the most in 2023 (42 documents). Malaysia, Indonesia, and Nigeria were the top contributors, and INCEIF University and the International …

Development Of A High-Doppler Shift Optical Simulator To Test Femtosecond-Level Optical Time-Frequency Transfer, Matthew S. Bigelow, Kyle W. Martin, Nolan Matthews, Benjamin K. Stuhl, Richard Gonzales, Alexandre De Pinho E Braga, John Elgin, Kimberly A. Frey

Space Dynamics Laboratory Publications

We have developed an optical simulator to test real-time optical two-way time–frequency transfer at the femtosecond level capable of simulating relative motion between two linked optical clock nodes up to Mach 1.8 with no moving parts. The technique is enabled by artificially Doppler shifting femtosecond pulses from auxiliary stabilized optical frequency combs. These pulses are exchanged between the nodes to simulate the Doppler shifts observed from a changing optical path length. We can continuously scan the simulated velocity from 14 to 620 m s⁻¹ while simultaneously measuring velocity-dependent clock shifts at much higher velocities than previously recorded. This system …

Barriers To Digital Payment Adoption In Saudi Arabia: A Plithogenic Indetermhypersoft Complex Refined Modelling Approach, Mohanned H. Alharbi

Sustainable Machine Intelligence Journal

Digital payments are central to Saudi Arabia's financial modernization under Vision 2030. While infrastructure and regulations have advanced rapidly, adoption is still hindered by barriers such as security concerns, unclear costs, usability issues, and religious ambiguity. Standard analytical models often struggle to evaluate these barriers because user feedback is frequently incomplete, conflicting, or vague. To address this uncertainty, this paper proposes a new decision-making framework: the Plithogenic IndetermHyperSoft Complex Refined Neutrosophic model (PIHCRN-DPA). This model integrates advanced mathematical concepts to handle complexity. It uses refined neutrosophic sets to process degrees of truth and indeterminacy, while complex sets account for contextual …

The M-Clean Graph Of A Finite Commutative Ring, Susan F. El-Deken, Harald Fripertinger, Aya Gamal

Sustainable Machine Intelligence Journal

We study m-clean graphs of finite commutative rings R, which are a generalization of clean graphs. Their vertices are pairs of m-potent elements and units of R. These graphs can be described as Cartesian sums or co-normal products of two graphs. In particular we explore under which conditions the subgraph involving only non-zero m-potent elements is connected and we determine the degrees of its vertices. Moreover, we characterize under which conditions on two rings the corresponding m-clean graphs are isomorphic.

Agentic Ai In 6g Wireless Security: Methods, Applications, And Challenges, Zekra Sakr, Mona Mohamed

Sustainable Machine Intelligence Journal

The move from 5G to 6G networks brings new opportunities but also major challenges, especially in security. Static machine learning and deep learning models are two examples of traditional AI techniques that frequently fail because they are unable to adequately adapt to rapidly evolving threats or provide a clear explanation for their choices. Agentic AI presents an achievable strategy to enhance the security, adaptability, and reliability of 6G systems through its capacity for perception, reasoning, and autonomous action. In this study, we present a comprehensive evaluation of 6G cybersecurity in relation to agentic AI. We evaluate current research, point out …

Batf2 Is A Glutamine-Responsive Tumour Suppressor Required For Type-I Interferon-Dependent Anti-Tumour Immunity, Wang Gong, Hülya F Taner, Yuesong Wu, Yumin He, Xingwu Zhou, Zaiye Li, Xin Hu, Charisse Ursin, Kala Chand Debnath, Kohei Okuyama, Qiang Hu, Christopher R Donnelly, Felipe Nör, Chamila D Perera, Emily Bellile, Arash Yunesi, Zhiqian Zhai, Mei Zhao, Wanqing Cheng, Zackary R Fitzsimonds, Luke Broses, Jiaqian Li, Shadmehr Demehri, Deepak Nagrath, Gregory T Wolf, Andrew G Sikora, Yanbao Yu, Haitao Wen, Lei Wei, Steven B Chinn, Jeffrey N Myers, Shizuo Akira, Yuying Xie, James J Moon, Yu Leo Lei

Faculty, Staff and Student Publications

Recent evidence highlights the significance of a new type of tumour suppressors, which are not frequently mutated but inhibited by metabolic cues in cancers. Here, we identify BATF2 as a tumour suppressor whose expression is epigenetically silenced by glutamine in Head and Neck Squamous Cell Carcinomas (HNSCC). BATF2 correlates with type-I interferon and Th1 signatures in human HNSCC, with correlation coefficients even stronger than those of the positive control, STING. The phosphorylation of BATF2 at serine 227 promotes the oligomerization of STING. BATF2 deficiency or high glutamine levels result in higher oxygen consumption rates and metabolic profiles unfavorable for …

Identifying Research Priorities For Post-Collision Care In The United Kingdom: Protocol For A Road Injury Priority Setting Partnership, Tim Nutbeam, Caroline Leech, Claire E Baker, Elizabeth Box, Lauren R Rodgers, Kerry Dungay, Louise Johnson, Brian Lee, Marilyn Macqueen, Rob Fenwick, Ian Marritt, Ian Dunbar, Ed B.G. Barnard

Peninsula Medical School

Background: Road traffic injury remains a significant global health challenge, causing over 1.2 million deaths and tens of millions of non-fatal injuries each year. In the United Kingdom (UK), more than 1,600 people died and nearly 30,000 sustained serious injuries on the roads in 2024. While improvements in vehicle design, road infrastructure, emergency response, and road user behaviour have contributed to a sustained reduction in road deaths over recent decades, outcomes for those injured remain variable, and post-collision care has received comparatively less research attention. The Road Injury Chain of Survival framework identifies five interdependent stages where timely, coordinated interventions …

Communication Factors Influencing Smallholder Farmers' Adoption Of Climate Change Adaptation Measures In Kenya’S Embu County, Olive Wanjiru Ndwiga, Dominic Mutambu, Daniel Manguriu, Monicah Mucheru-Muna

Journal of Environmental Science and Sustainable Development

Climate change in Kenya has severely impacted the agricultural sector, affecting food security. It is crucial to enhance farmers’ adaptive capacity to cope with these threats. Effective communication of climate variation risks and coping measures is essential to improve farmers' adaptive capacity. Nevertheless, the adoption of adaptation measures remains low. This is because the influence of communication factors remains underexplored. Therefore, this study focuses on exploring the communication factors affecting the adoption of climate variation adaptation measures in Embu County. The study was conducted in 2023 and 2024 and analysed using the Statistical Package for Social Sciences (SPSS) software. The …

The Concise Guide To Pharmacology 2025/26: Catalytic Receptors, Stephen P. H. Alexander, Doriano Fabbro, Chloe J. Peach, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Laura Kilpatrick, Doris Koesling, Michaela Kuhn, Birgit Leitinger, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of …

Decolonizing Knowledge As Epistemic Justice: Key Conceptual Tendencies From The Global South, Richard Sambaiga

Tanzania Journal of Sociology

The project of decolonising knowledge has gained renewed prominence as scholars confront enduring epistemic injustices and structural inequalities embedded in global systems of knowledge production. Situated within long-standing anticolonial and postcolonial intellectual struggles, this article interrogates key conceptual dilemmas that continue to shape contemporary debates on decoloniality. Adopting a commentary orientation, it examines what it means to decolonise knowledge by engaging the historical foundations of decolonial thought alongside contemporary critiques that expose the persistence of epistemic hierarchies within modern academic institutions. The article argues that, without conceptual clarity, the decolonial project risks becoming analytically misguided and politically misdirected, potentially reproducing …

Theorizing ‘Magwangala’ As An Unorthodox Livelihood In Geita, Tanzania, Albert Tibaijuka

Tanzania Journal of Sociology

The increasing contestation of Magwangala as a livelihood in Geita, Tanzania, invokes a scholarly desire to further the constitution of the term beyond its traditional constructs. Following the present framing of magwangala as a disruptive, hazardous, contentious, and risky engagement; including the sanctions against it and the disparaging remarks upsurging the oppression of its actors, an attempt to advance its comprehension is of paramount importance. Given the nature of Magwangala business and the evident ramifications, its contestation is inevitable and unlikely to yield a uniform understanding. This paper, therefore, draws from the grueling life experiences endured by magwangala dealers in …

Patient And Systemic Barriers To Cancer Care: Implications For Delayed Prostate Cancer Detection In Tanzania, Jane Senga John

Tanzania Journal of Sociology

Prostate cancer is a leading cause of cancer-related mortality among men in Tanzania, with most cases diagnosed at advanced stages. This study explores the interplay of patient-level and systemic barriers that contribute to delayed prostate cancer detection within a tertiary hospital context. Conducted at Bugando Medical Centre in Mwanza, the research employed in-depth interviews with 25 purposefully selected participants, including patients, oncologists, spouses and traditional healers. Thematic analysis was used and guided by Paul Farmer’s structural violence model and Courtenay’s theory of gender and health to interpret how cultural, economic, and structural factors shape health-seeking behaviours. Findings reveal that delays …

Electrochemical Characterization And Modulation Of Biological Processes, Yue-Qi Li, Wei-Hua Huang, De-Chen Jiang, Bao-Hong Liu, Bin Su, Yang Tian, Jing-Juan Xu, Ping Yu, Feng Zhao, Huang-Xian Ju, Jing-Hong Li

Journal of Electrochemistry

Electrochemical processes lie at the core of biological function, governing energy transduction, metabolic flux, and molecular signaling. Recent advances in electrochemical science now allow these processes to be probed and controlled with unprecedented spatial, temporal, and chemical resolution. In this review, we present an integrated framework that progresses from fundamental mechanisms to analytical technologies and functional modulation. We begin by outlining electron transfer pathways in mitochondrial respiration, microbial extracellular electron transfer, and DNA- and protein-based charge conduction, followed by the principles of photon-electron conversion in photosynthesis and the central role of redox equilibrium in coordinating cellular responses. We then highlight …

Empirical Analysis Of Machine Learning Models For Predicting Equipment Failures Using Iot Sensor Data, Yusuf Shodiyevich Avazov

Chemical Technology, Control and Management

This article examines the problem of detecting and predicting industrial equipment faults using IoT sensor data through machine learning techniques. Sensor readings such as temperature, vibration, pressure, voltage, and current, as well as FFT-based features, were statistically analyzed. Class imbalance and low signal informativeness were identified as key factors limiting model accuracy. Results obtained from Logistic Regression, Random Forest, and XGBoost models were comparatively evaluated, showing that when ROC-AUC values remain around 0.5, distinguishing fault and non-fault states becomes challenging. Correlation and feature-importance analyses confirmed the absence of strong dominant indicators. The findings highlight the need to improve sensor architecture …

Analog Systems Of Physical Quantities And Their Graph Models In Determining The Parameters Of Mechatronic Modules, Temurbek Omonboevich Rakhimov, Elmira Eshmurod Qizi Raxmanova, Guzal Khujaniyazova

Chemical Technology, Control and Management

This article is dedicated to the analogy systems of physical quantities and their graph models in determining the parameters of mechatronic modules. It presents the general sets and fundamental laws of analogy systems of physical quantities and their elements for determining the parameters of mechatronic modules. Based on the general sets and fundamental laws of analogy systems of physical quantities and their elements, principles have been developed for mechatronic modules with a heterogeneous structure consisting of electrical, magnetic, and mechanical parts. In these modules, the field as a form of matter exists, forming the basis for developing mathematical models to …

Models And Algorithms Of Control Mechanisms In Information Exchange Processes, Madina M. Fozilova, Dilshoda N. Uchqunova

Chemical Technology, Control and Management

In modern digital systems, efficient and reliable information exchange is essential for the stability of corporate systems. Traditional data management models struggle to detect and eliminate invalid, incomplete data at early stages, resulting in reduced accuracy and system inefficiency. This article proposes an advanced framework for controlling information exchange processes through the development of a Verification and Filtering algorithm. The algorithm operates within a multi-layered conceptual model that includes data input, control, validation, optimization, and decision layers. Acting as the core component, the Verification and Filtering algorithm distinguishes valid from invalid records in real time, ensuring data integrity before storage. …

Mechanical Improvements And Control Implementation On A Biomimetic Quadruped Model, Matthew Jack Lutz

Dissertations and Theses

Robotic development started billions of years after earth first began biological prototyping. While the evolutionary process in animals is quite different from robotic prototyping, it still remains no surprise that animals remain more agile, more efficient, and more adaptable than even the most advanced engineered robots to date, simply due to the sheer length of their improvement process. While bridging this improvement gap between deficits in robots and the abilities of animals is difficult, a specific subfield of robotics engineering has attempted to do so using biomimetic robotics. At Portland State, the Agile and Adaptive Robotics Lab (AARL) studies these …

Interdisciplinary Full-Mouth Rehabilitation Addressing Midline Shift And Gingival Discrepancies Through Crown Lengthening And Root Reshaping Procedures: A Case Report, Ghida Lawand, Roudy Khayat, Stephanie Khalaf, Tamara Rebeiz, Hani Tohme

International Arab Journal of Dentistry

This report describes a minimally invasive approach to address midline deviation and gingival discrepancies in a 50-year-old patient seeking rapid aesthetic results. Treatment included prosthetic crown lengthening, selective root modification, and biologic shaping to correct a 3 mm midline shift. Digital smile design and CAD/CAM technology guided the fabrication of zirconia restorations, achieving improved midline alignment, gingival harmony, and smile aesthetics with high patient satisfaction. This technique provides an efficient alternative for complex aesthetic cases.