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Articles 3901 - 3930 of 23126
Full-Text Articles in Entire DC Network
Icipe Monthly Digest – Volume 1, Issue 10, October 2025, International Centre Of Insect Physiology And Ecology (Icipe)
Icipe Monthly Digest – Volume 1, Issue 10, October 2025, International Centre Of Insect Physiology And Ecology (Icipe)
icipe Newsletters
No abstract provided.
Healthier Families And God's Creation, Ingrid Weiss Slikkers, Roberta Colwell
Healthier Families And God's Creation, Ingrid Weiss Slikkers, Roberta Colwell
Lake Union Herald
No abstract provided.
The Gamification Of Banking, Colleen Baker, Christopher K. Odinet
The Gamification Of Banking, Colleen Baker, Christopher K. Odinet
Faculty Scholarship
Gamification is coming to banking. This phenomenon is already gain-ing ground in advertising, healthcare, manufacturing, and, more recently, with the GameStop and AMC meme stock saga in securities trading. The idea behind gamification is to make transactions seem fun, playful, and even casino-like in order to elicit habit-forming, addictive-like effects with consumers. This Article argues that the rise of financial technology (“fintech”) firms and their ever-growing business relationships with incumbent financial institutions has created the necessary conditions for gamification to take hold in the banking sector. In order to explore this observation, we undertake a study of current examples of …
Traditional And Computational Canons, Eric H. Martinez
Traditional And Computational Canons, Eric H. Martinez
Faculty Scholarship
As part of the rise of modern textualism, dictionaries and linguistic canons have become a ubiquitous part of legal interpretation. One longstanding question is whether judges citing these tools sincerely attempt to follow the meaning of a text, or if their invocation is merely window-dressing for a preferred outcome. The practical significance of this question extends across all major doctrinal areas, and with the Supreme Court’s overturning of Chevron deference, its importance is only to grow, as courts are now instructed to use every tool at their disposal to resolve ambiguity when interpreting a law. This Article is the first …
Sex Worker Stigma, Morality And Ambivalent Sexism, Emily Kate Kinzel
Sex Worker Stigma, Morality And Ambivalent Sexism, Emily Kate Kinzel
Dissertations and Theses
Sex worker stigma has received limited attention in psychological research. Although stigma is often theorized to relate to moral concerns, the relationship between stigma and moral concerns has not been empirically established. This study aims to address these gaps by developing a measurement tool for attitudes towards sex workers--specifically an implicit association test (IAT)--and explore the relationships between sex worker stigma, moral concerns, and ambivalent sexism. Mock policy questions on the criminalization and punishment of sex workers were also included to approximate behavioral intentions of participants. A cross-sectional correlational study of 168 community members found evidence that both moral concerns …
A Dialetical Materialist Reading Of Language And Ideology In The Metamorphosis, Sidhanth Sethi
A Dialetical Materialist Reading Of Language And Ideology In The Metamorphosis, Sidhanth Sethi
Harriet L Wilkes Honors College Theses 2020 - Present
In this paper I use a dialectical materialist conception of ideology to analyze how it functions through language in Franz Kafka’s story The Metamorphosis. Beginning with Hegel’s account of consciousness as constituted through contradiction and its material reorientation in Marx and Engels, this project situates ideology within the social relations that shape human life. I then employ Evald Ilyenkov’s conception of material generation and Valentin Volosinov’s semiotic theory, arguing that signs constitute the material medium through which ideological meaning is produced and through which consciousness learns to misrecognize its own conditions. Using this framework, I interpret Gregor Samsa’s transformation as …
Numerical Simulations Of Highly Eccentric Systems Of Binary Neutron Stars With Spin, Victoria White
Numerical Simulations Of Highly Eccentric Systems Of Binary Neutron Stars With Spin, Victoria White
Harriet L Wilkes Honors College Theses 2020 - Present
Binary Neutron Star (BNS) mergers are among the most energetic events in the universe, producing gravitational waves, electromagnetic radiation, and heavy elements. While previous research has utilized simulations for collisions, few studies have accounted for how the spin of the stars affects mergers. This thesis contains a general overview of the topic and a research component conducted in the field of numerical relativity. High-performance computing was used to simulate BNS collisions, examining how spin affects the inspiral, merger, and post-merger phases. Computations used the Einstein Toolkit, Cactus framework, and the numerical tool developed by the FAU Relativity Group, Sgrid. The …
Productive Energy, As Determined By Arkansas Net Energy, Predicts Broiler Processing Weights, Carcass Market Value, And Gross Profit, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon
Productive Energy, As Determined By Arkansas Net Energy, Predicts Broiler Processing Weights, Carcass Market Value, And Gross Profit, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon
Poultry Science Faculty Publications and Presentations
This study assessed the sensitivity of Productive Energy (PE) to breast meat production, feed efficiency, and broiler economics, developed models for processing traits and economics, and examined economics dynamics. The experimental design involved 96 pens, 12 per block and eight blocks, with each pen within block receiving one of 12 dietary treatments for one week. Treatment diets, varying in amino acid concentrations, starch, and energy densities, were control-fed. The weights of processing body parts and net energy for gain (NEg) were determined with Dual-Energy X-Ray Absorptiometry, and fed heat production, fasting heat production (FHP), and net energy for maintenance (NEm) …
Smart Search Results For Growth And Economic Performance Comparison Of Twenty-Year-Old ... Refine Results For Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition 21 Of 94 Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon
Smart Search Results For Growth And Economic Performance Comparison Of Twenty-Year-Old ... Refine Results For Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition 21 Of 94 Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon
Poultry Science Faculty Publications and Presentations
This study determined the sensitivity of productive energy (PE; Arkansas Net Energy) to performance and body composition and developed predictive models based on PE. Chicks (2,148 day-old ones) were placed in 96 pens and assigned to one of 12 dietary treatments, including varying concentrations of total digestible amino acids (TDAA), digestible CP (dCP), digestible fat (dFat), digestible starch, and non-starch polysaccharides (NSP). Eight replications per treatment, one per block, were used, being the block consecutive groups of birds weekly starting the seven-day experimental period. In each block, birds were control fed to meet similar ME intake, placed in calorimetry chambers …
Effects Of Heat Stress And Depressed Feed Intake On The Cecal And Ileal Microbiota Of Broiler Chickens, Philip M. Campos, Elizabeth S. Greene, Monika Proszkowiec-Weglarz, Sami Dridi
Effects Of Heat Stress And Depressed Feed Intake On The Cecal And Ileal Microbiota Of Broiler Chickens, Philip M. Campos, Elizabeth S. Greene, Monika Proszkowiec-Weglarz, Sami Dridi
Poultry Science Faculty Publications and Presentations
Chronic heat stress (HS) is known to depress feed intake (FI) and growth in broiler chickens, and may alter the gut microbiota and health, however, the amplitude and duration of each (HS and depressed FI) effect on gut microbiota is still unclear. This study aimed to determine the effects of chronic and acute HS on the cecal and ileal microbiota profiles. Broilers were subjected to thermoneutral (TN, 23 degrees C) or chronic cyclic HS (CHS, 8 h/d, 35 degrees C) condition from d29-42, and one group to acute HS (AHS, 2 h, 35 degrees C) at d42. To distinguish between …
Effects Of Caprylic Acid On The Cecal Colonization Of Multidrug-Resistant Salmonella Heidelberg And The Cecal Microbiome In Broiler Chickens, Shijinaraj Manjankattil, Dhananjai Muringattu Prabhakaran, Anup Kollanoon Johny, Claire Peichel, Divek V.T. Nair, Grace Dewi, Jason Langlie, Trevor J. Gould, A. M. Donoghue
Effects Of Caprylic Acid On The Cecal Colonization Of Multidrug-Resistant Salmonella Heidelberg And The Cecal Microbiome In Broiler Chickens, Shijinaraj Manjankattil, Dhananjai Muringattu Prabhakaran, Anup Kollanoon Johny, Claire Peichel, Divek V.T. Nair, Grace Dewi, Jason Langlie, Trevor J. Gould, A. M. Donoghue
Poultry Science Faculty Publications and Presentations
This study determined the efficacy of in-feed supplementation of a medium-chain fatty acid, caprylic acid (CA), on the cecal colonization of multidrug-resistant (MDR) Salmonella Heidelberg (SH) and its effect on the cecal microbiome of commercial broilers. A total of 24, 4-week-old commercial Ross 708 chickens were randomly allocated to two replicates of four treatment groups in eight BSL2 isolators (3 birds/isolator): Negative control (NC), Positive Control (PC), Antibiotic group (AB), and caprylic acid (CA) groups. The birds received a Salmonella-free standard corn-soy-based diet, with the broilers in the AB receiving 50 g/ton bacitracin methylene disalicylate, and the CA group receiving …
The Moderating Effects Of Community Involvement On The Association Between Witnessed Community Violence And Mental Health Outcomes Among Black Adolescents, Curtisha Tamara Shacklewood
The Moderating Effects Of Community Involvement On The Association Between Witnessed Community Violence And Mental Health Outcomes Among Black Adolescents, Curtisha Tamara Shacklewood
Theses and Dissertations
Black youth and adolescents are at a disproportionately high risk for experiencing community violence exposure (CVE) and the potential influence it may have on psychological functioning. Research posits that Black youth who experience community violence are at a significantly higher risk of experiencing elevated internalizing symptoms (e.g., depression) and externalizing symptoms (e.g., delinquency). Previous research has utilized the ecological model to investigate interpersonal protective factors that potentially buffer the effects of CVE, including parental support and family characteristics. However, there is little research that explores community-level factors, such as community activities (e.g., youth activities and parental perception of collective efficacy) …
Developing A Dynamic Bilingual Space In An Early Childhood Korean Heritage Language Classroom Through Multimodal Translanguaging Pedagogy, Kyungjin Hwang
Developing A Dynamic Bilingual Space In An Early Childhood Korean Heritage Language Classroom Through Multimodal Translanguaging Pedagogy, Kyungjin Hwang
Theses and Dissertations
Drawing on translanguaging theory and multimodal literacy, this dissertation examines how a multimodal translanguaging pedagogy can create a dynamic bilingual space in a Korean heritage language classroom in the southeastern United States. Using a teacher-research design and thematic analysis of classroom video recordings and student artifacts, the study explored ten instructional modules with Korean-American children aged five to six. It first identified the core components of the pedagogy, its framework, curriculum content, and teacher strategies, and then analyzed how children flexibly used Korean and English across modes such as speaking, writing, and drawing. Findings revealed diverse translanguaging forms and functions. …
The Role Of Prelimbic Projections To The Rostromedial Tegmnetal Nucleus In Cue Discrimination, Emma Lane Carlson
The Role Of Prelimbic Projections To The Rostromedial Tegmnetal Nucleus In Cue Discrimination, Emma Lane Carlson
Theses and Dissertations
Maladaptive decision-making, such as persistent reward seeking despite negative consequences, is a hallmark of substance use disorder (SUD) and related psychiatric conditions. These behaviors are thought to arise from impairments in aversive learning and disrupted neural signaling that normally supports behavioral inhibition. The prelimbic cortex (PL) plays a critical role in encoding cue–outcome associations and exerting top-down control over behavior, while the rostromedial tegmental nucleus (RMTg) serves as a GABAergic inhibitor of midbrain dopamine neurons in response to aversive stimuli. Although both structures have been implicated in reward and avoidance processes, little is known about how direct PL-RMTg projections contribute …
Anthropomorphism In Language And Thought: The Effect Of Agentive Linguistic Framing On Readers’ Perceptions Of Ai Animacy, Dawson Petersen
Anthropomorphism In Language And Thought: The Effect Of Agentive Linguistic Framing On Readers’ Perceptions Of Ai Animacy, Dawson Petersen
Theses and Dissertations
Over the past decade, deep learning AI systems have gone from academic obscurity to near cultural centrality in the developed world. As these technologies become increasingly integrated into daily life, there is growing cause for concern about AI anthropomorphism—i.e., the perception of AIs as more human than they really are. Despite the potential risks, AI developers continue to market their technologies using agentive language that seems to be designed to encourage anthropomorphism. The current dissertation utilizes behavioral and eye-tracking methods to examine the relationship between agentive linguistic framing and AI anthropomorphism in both controlled judgments and automatic inferences. The results …
Behind The Gens: A Bioarchaeological Study Of Kinship Structure And Social Change In Iron Age Latium, Italy, Andrea Noemí Acosta Caballero
Behind The Gens: A Bioarchaeological Study Of Kinship Structure And Social Change In Iron Age Latium, Italy, Andrea Noemí Acosta Caballero
Theses and Dissertations
The cemetery of Osteria dell’Osa is the only completely published Iron Age cemetery from Latium. Its research legacy continues as dietary, mobility, and biological affinity patterns were reconstructed through carbon, nitrogen, oxygen, and strontium isotope analyses and biodistance analysis using bone and dental samples for this dissertation project. The main hypotheses tested are:
a) The diet of people buried at Osteria dell’Osa during the Iron Age likely consisted of mostly grains like wheat and barley, which may yield low carbon isotope signatures;
b) The protein consumption of the diet of people at Osteria dell’Osa was mainly composed of terrestrial protein …
Gut Microbiome Dynamics In Heart Failure And The Therapeutic Potential Of Nmeg-Cgrp, Kamryn Michael Gleason
Gut Microbiome Dynamics In Heart Failure And The Therapeutic Potential Of Nmeg-Cgrp, Kamryn Michael Gleason
Theses and Dissertations
Heart failure (HF) is increasingly recognized as a multisystem disease often linked to gut dysbiosis; however, its specific effects on gut microbial composition remain poorly understood. This study examined long-term changes in the gut microbiome in a murine HF model induced by transverse aortic constriction (TAC) and evaluated the effects of NMEG-CGRP. TAC mimics pressure overload-induced cardiac dysfunction, replicating key features of HF. CGRP, a neuropeptide with vasodilatory and cardioprotective effects, shows potential as a therapy for HF but is limited by rapid degradation. A stabilized analog, NMEG-CGRP, was used to assess its impact on cardiac and gastrointestinal health. Mice …
Multiscale Geometric Analysis In Endovascular Therapies: Ex Vivo, In Silico Approaches, Dima Hussein Ali Bani Hani
Multiscale Geometric Analysis In Endovascular Therapies: Ex Vivo, In Silico Approaches, Dima Hussein Ali Bani Hani
Theses and Dissertations
In this work, we address a persistent global challenge of vascular disease, specifically peripheral artery disease (PAD), and arteriovenous fistula (AVF) complications in patients with end-stage kidney disease (ESKD). The important role of vascular geometry in disease intervention plans and the development of endovascular therapeutic strategies (e.g., Drug-coated balloon (DCBs)) is critical in addressing these challenges.
This study evaluates the feasibility of co-delivery of paclitaxel (PTX) and valsartan (VAL) using urea-based coatings in DCB, analyzes the coating morphology and microstructural changes to improve therapeutic results. A computational finite element model was developed to complement experimental work, simulate tissue-coating interactions, compute …
Development Of A Strategy To Neutralize Ccl8 Activity And Ablate Ccl8 Cellular Targets, Bernardo Chavez
Development Of A Strategy To Neutralize Ccl8 Activity And Ablate Ccl8 Cellular Targets, Bernardo Chavez
Theses and Dissertations
The chemokine CCL8 (monocyte chemoattractant protein-2) is a versatile signaling molecule involved in tumor progression, immune cell recruitment, and therapeutic resistance. Through activation of receptors including CCR1, CCR2B, and CCR5, CCL8 promotes leukocyte trafficking, epithelial–mesenchymal transition, and the establishment of immunosuppressive tumor microenvironments. In breast cancer and inflammatory diseases, elevated CCL8 levels correlate with poor clinical outcomes, making it a promising therapeutic target.
A strategy was developed to block CCL8 activity and selectively ablate CCL8 receptor expressing cells. A neutralizing monoclonal antibody, 1G3E5, was identified from a panel of murine candidates based on high affinity CCL8 binding. Sequencing revealed two …
The Role Of Fibroblast Activation Protein On Left Ventricular Growth And Extracellular Matrix Remodeling As A Function Of Age And Pressure Overload, Amelia Marie Churillo
The Role Of Fibroblast Activation Protein On Left Ventricular Growth And Extracellular Matrix Remodeling As A Function Of Age And Pressure Overload, Amelia Marie Churillo
Theses and Dissertations
Fibroblast activation protein (FAP) is abundantly expressed in cancer associated fibroblasts and contributes to extracellular matrix (ECM) remodeling. Recent studies using imaging techniques have identified increased levels of FAP in the left ventricle (LV) of patients identified as at risk for developing heart failure. However, the role of FAP in regulated LV myocardial structure and function remains unclear. This project tested two hypotheses: First, genetic ablation of FAP would modify LV structure and function and be more pronounced with aging. Second, genetic ablation of FAP would modify LV structure and function with LV pressure overload (LVPO) accompanied by ECM remodeling.
Fue Evocations: A Culturally-Informed Performance Guide To Approaching Works For The Western Concert Flute Inspired By Traditional Japanese Flutes, Chase Michael Ketron
Fue Evocations: A Culturally-Informed Performance Guide To Approaching Works For The Western Concert Flute Inspired By Traditional Japanese Flutes, Chase Michael Ketron
Theses and Dissertations
The purpose of this document is to create a culturally-informed and aesthetically accurate performance preparation guide for Western concert flute players seeking to perform works inspired by traditional Japanese flutes, or fue, such as the shakuhachi and nohkan.1 While many pieces like these exist, there are limited resources detailing how to emulate the traditional Japanese flutes and their performance practices. The composers of these works often do well to provide notation for producing the specific sounds or effects they are trying to replicate, but these are non-standardized and thus vary from composer to composer. In addition, the traditional …
Multi-Layer Decision Making For Long-Term Autonomous Mission Based On Dual Process Theory, Shruti Jadhav
Multi-Layer Decision Making For Long-Term Autonomous Mission Based On Dual Process Theory, Shruti Jadhav
Theses and Dissertations
Unmanned aerial vehicles (UAVs) are increasingly used in precision agriculture, where extended autonomous operation is required for monitoring, intervention, and field management. However, achieving long-term autonomy remains challenging due to battery constraints, environmental uncertainty, and the need to balance exploration with event-driven tasks. To address these challenges, a multi-layer decision-making framework inspired by Dual Process Theory (DPT) is developed. The framework combines reactive return-tobase strategies, exploratory navigation, and directional bias from prior missions, with a conflict-monitoring mechanism that adapts system behavior based on real-time conditions. The approach is implemented in a simulated agricultural grid environment, demonstrating improved adaptability and coverage …
A Qualitative Study Of Middle School Teachers’ Experiences Integrating Computer Coding Into Mathematics Classrooms, George William Austin Iii
A Qualitative Study Of Middle School Teachers’ Experiences Integrating Computer Coding Into Mathematics Classrooms, George William Austin Iii
Theses and Dissertations
As computers become more accessible in schools nationwide, teachers are embracing them to impact achievement positively (Brudno, 2013; Cetin, 2016). As a result, computer coding instruction has gained attention as a strategy for providing students with skills that will serve them both pre and post-graduation (Burke & Kafai, 2013; Yadav et al., 2016; Ng, 2017). Computer coding is the process of providing instructions for a computer to follow. In 2017, the South Carolina State Board of Education approved Computer Science and Digital Literacy standards for all K-8 public schools in the state of South Carolina (South Carolina Department of Education, …
Normal Urinary Oxalate Excretion In 4-Hydroxy-2-Oxo-Glutarate Aldolase 1 (Hoga1) Deficient Mice With Agt Expression In Peroxisomes And Not In Mitochondria, Iolanda Boffa, Rosa Ferriero, Mariarosaria Cancelliere, Edoardo Nusco, Leonardo Gatticchi, Donna Palmer, Philip Ng, Pasquale Piccolo, Barbara Cellini, Kyle Wood, John Knight, Nicola Brunetti-Pierri
Normal Urinary Oxalate Excretion In 4-Hydroxy-2-Oxo-Glutarate Aldolase 1 (Hoga1) Deficient Mice With Agt Expression In Peroxisomes And Not In Mitochondria, Iolanda Boffa, Rosa Ferriero, Mariarosaria Cancelliere, Edoardo Nusco, Leonardo Gatticchi, Donna Palmer, Philip Ng, Pasquale Piccolo, Barbara Cellini, Kyle Wood, John Knight, Nicola Brunetti-Pierri
Faculty, Staff and Students Publications
Primary hyperoxaluria type 3 (PH3) is caused by mutations in Hoga1 gene. PH3 individuals develop nephrolithiasis, but the mechanism underlying hyperoxaluria is unclear and a mouse model recapitulating the human disease can provide insights into the pathogenesis of PH3. Hoga1−/− mice do not have increased urinary oxalate excretion, probably due to the murine mitochondrial alanine-glioxylate-aminotransferase (AGT) activity, which in humans is only expressed in peroxisomes. However, Hoga1−/−/Agxt−/− mice with AGT installed on peroxisome and not on mitochondria did not show increased urinary oxalate, suggesting that AGT expression in both cellular compartments is not an explanation for …
Protein Kinase Rock1 Activates Mitochondrial Fission Linking To Oxidative Stress And Muscle Atrophy, Meijun Si, Jihong Chen, Rizhen Yu, Hongchun Lin, Feng Li, Sungyun Jung, Sandhya S Thomas, Farhard R Danesh, Yanlin Wang, Hui Peng, Zhaoyong Hu
Protein Kinase Rock1 Activates Mitochondrial Fission Linking To Oxidative Stress And Muscle Atrophy, Meijun Si, Jihong Chen, Rizhen Yu, Hongchun Lin, Feng Li, Sungyun Jung, Sandhya S Thomas, Farhard R Danesh, Yanlin Wang, Hui Peng, Zhaoyong Hu
Faculty, Staff and Students Publications
Introduction: Chronic kidney disease (CKD) is associated with protein-energy wasting, characterized by a reduction in muscle mass and strength. Although mitochondrial dysfunction and oxidative stress are implicated in the pathogenesis of muscle wasting, underlying mechanisms remain unclear.
Methods: Here, we used transcriptomic analysis, metabolomics analyses, and mouse gene manipulation to investigate the effects of mitochondrial plasticity and oxidative stress on muscle wasting the subtotal nephrectomy mouse models of CKD. The mice with CKD were age- and sex-matched to sham-operated controls.
Results: Through these approaches, Rho-associated kinase ROCK1 emerged as a key molecule responsible for the observed mitochondrial fission and oxidative …
Lac-Phe Induces Hypophagia By Inhibiting Agrp Neurons In Mice, Hailan Liu, Veronica L Li, Qingzhuo Liu, Yao Liu, Cunjin Su, Hueyxian Wong, Na Yin, Hesong Liu, Xing Fang, Kristine M Mcdermott, Hueyzhong Wong, Meng Yu, Longlong Tu, Jonathan C Bean, Yongxiang Li, Mengjie Wang, Yue Deng, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Junying Han, Megan E Burt, Sanika V Jossy, Chunmei Wang, Yongjie Yang, Benjamin R Arenkiel, Dong Kong, Yang He, Jonathan Z Long, Yong Xu
Lac-Phe Induces Hypophagia By Inhibiting Agrp Neurons In Mice, Hailan Liu, Veronica L Li, Qingzhuo Liu, Yao Liu, Cunjin Su, Hueyxian Wong, Na Yin, Hesong Liu, Xing Fang, Kristine M Mcdermott, Hueyzhong Wong, Meng Yu, Longlong Tu, Jonathan C Bean, Yongxiang Li, Mengjie Wang, Yue Deng, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Junying Han, Megan E Burt, Sanika V Jossy, Chunmei Wang, Yongjie Yang, Benjamin R Arenkiel, Dong Kong, Yang He, Jonathan Z Long, Yong Xu
Faculty, Staff and Students Publications
Lactate-derived N-lactoyl-phenylalanine (Lac-Phe) was recently identified as an lactate-derived circulating metabolite that reduces feeding and obesity, but mechanisms that underlie the metabolic benefits of Lac-Phe remain unknown. Here we demonstrated that Lac-Phe directly inhibits hypothalamic neurons that express Agouti-related protein (AgRP), resulting in an indirect activation of anorexigenic neurons in the paraventricular nucleus of the hypothalamus (PVH). We also found that both AgRP inhibition and PVH activation are required to mediate Lac-Phe-induced hypophagia. Further, we show that Lac-Phe inhibits AgRP neurons via activating the ATP-sensitive potassium (KATP) channel, and inhibition of the KATP channel blunts effects of Lac-Phe to suppress …
Adeno-Associated Virus-Mediated Silencing Of Sox4 Leads To Long-Term Amelioration Of Liver Phenotypes In Mouse Models Of Alagille Syndrome, Duncan Fox, Jun Xie, Jennifer L Burwinkel, Josh M Adams, Kashish Chetal, Marzieh Keivandarian, Yaniv Faingelernt, Sanjay Subramanian, Mario F Lopez, Anna L Peters, Nathan Salomonis, Neda Zarrin-Khameh, Guangping Gao, Stacey S Huppert, Hamed Jafar-Nejad
Adeno-Associated Virus-Mediated Silencing Of Sox4 Leads To Long-Term Amelioration Of Liver Phenotypes In Mouse Models Of Alagille Syndrome, Duncan Fox, Jun Xie, Jennifer L Burwinkel, Josh M Adams, Kashish Chetal, Marzieh Keivandarian, Yaniv Faingelernt, Sanjay Subramanian, Mario F Lopez, Anna L Peters, Nathan Salomonis, Neda Zarrin-Khameh, Guangping Gao, Stacey S Huppert, Hamed Jafar-Nejad
Faculty, Staff and Students Publications
Background & aims: In patients with Alagille syndrome (ALGS), bile duct paucity often leads to severe cholestatic phenotypes for which liver transplantation remains the only definitive treatment. No Food and Drug Administration-approved mechanism-based strategies exist to enhance biliary development in ALGS or other diseases with bile duct paucity. We aimed to identify a therapeutic target to address this unmet need.
Methods: Preclinical ALGS mouse models lacking 1 copy of Jag1 with or without conditional deletion of 1 or both copies of Sox9 were used. Sox4 levels were reduced genetically or with adeno-associated virus 8 (AAV8) vectors driving a Sox4-silencing sequence. …
Alternative Polyadenylation Contributes To Fibroblast Senescence In Pulmonary Fibrosis, Jingjing Huang, Maria Jose Gacha-Garay, Yu Wang, Scott D Collum, Rene A Girard, Hydia Puente, Seung-Hee Yoo, Rahat Hussain, Jayeshkumar Patel, Manish Patel, Eric J Wagner, Hari Krishnayalamanchili, Harry Karmouty-Quintana, Zheng Chen, Tingting Mills
Alternative Polyadenylation Contributes To Fibroblast Senescence In Pulmonary Fibrosis, Jingjing Huang, Maria Jose Gacha-Garay, Yu Wang, Scott D Collum, Rene A Girard, Hydia Puente, Seung-Hee Yoo, Rahat Hussain, Jayeshkumar Patel, Manish Patel, Eric J Wagner, Hari Krishnayalamanchili, Harry Karmouty-Quintana, Zheng Chen, Tingting Mills
Faculty, Staff and Students Publications
Idiopathic pulmonary fibrosis (IPF) is a prevalent and deadly age-related disease characterized by chronic, progressive, and irreversible fibrosis. A key effector cell population in the fibroproliferative response is the fibroblasts. Fibroblast cell senescence gradually worsens during aging, and the acquisition of a senescence-associated secretory phenotype (SASP) turns senescent fibroblasts into pro-inflammatory cells. However, the mechanism promoting senescence in IPF, especially at the post-transcriptional level, is poorly understood. We recently discovered that Nudix Hydrolase 21 (NUDT21, also named CFIm25), an RNA-binding protein, plays a critical role in regulating the expression of SASP factors through alternative polyadenylation (APA). APA allows adding poly(A) …
Assessing Cognitive Abilities In Students With Hearing Loss And Specific Learning Disabilities, Pooja Gupta, Corinna V. Cole, William H. Blackwell
Assessing Cognitive Abilities In Students With Hearing Loss And Specific Learning Disabilities, Pooja Gupta, Corinna V. Cole, William H. Blackwell
Journal of Human Services: Training, Research, and Practice
This literature review synthesizes approximately 30 years of research on students from kindergarten through 12th grade with hearing impairments who are suspected of having a specific learning disability (SLD). Assessing SLDs in these students presents significant challenges, particularly when evaluating cognitive abilities using the Cattell-Horn-Carroll (CHC) theory of intelligence. This theory encompasses seven broad cognitive domains that influence academic success in reading, mathematics, and writing, including crystallized intelligence, fluid and sequential reasoning, long-term and short-term memory, visual processing, auditory processing, and processing speed. Since auditory processing is inherently affected in students with hearing impairments, this review excludes it from discussion. …
Become A Crea(I)Tive Director: Working With A.I. (Digital Illustration, Art29526-2kn, Graded Assignment, Fall 2025), Broderick Shoemaker
Become A Crea(I)Tive Director: Working With A.I. (Digital Illustration, Art29526-2kn, Graded Assignment, Fall 2025), Broderick Shoemaker
Open Educational Resources
Students choose a brand to give a visual identity overhaul. They assume the role of creative director and are tasked with using a.i. chatbots – their "workers – to create the required assets.