Digital Commons Network^™

Atg-3 Limits Orsay Virus Infection In C. Elegans And Regulates Collagen Pathways, Gowri Kalugotla, Vivien Marmerstein, Lawrence A. Schriefer, Leran Wang, Stephanie A. Morrison, Luis Casorla Perez, Gary A. Silverman, Tim Schedl, Stephen C. Pak, Megan T. Baldridge

2020-Current year OA Pubs

Autophagy is an essential cellular process which functions to maintain homeostasis in response to stressors such as starvation or infection. Here, we report that a subset of autophagy factors including ATG-3 play an antiviral role in Orsay virus infection of Caenorhabditis elegans. Orsay virus infection does not modulate autophagic flux, and re-feeding after starvation limits Orsay virus infection and blocks autophagic flux, suggesting that the role of ATG-3 in Orsay virus susceptibility is independent of its role in maintaining autophagic flux. atg-3 mutants phenocopy rde-1 mutants, which have a defect in RNA interference (RNAi), in susceptibility to Orsay virus infection …

Sarm1 Inhibition Maintains Axonal Integrity After Rat Sciatic Nerve Transection And Repair, Ryan Sachar, Tony Y Lee, Aaron Diantonio, Christopher J Dy, Jason Wever, Jeff Milbrandt, David M Brogan

2020-Current year OA Pubs

PURPOSE: Sterile alpha and TlR motif containing-1 (SARM1) protein has been demonstrated to play a critical role in the initiation of Wallerian degeneration after nerve injury. The goal of this study was to assess whether blockade of SARM1 activity inhibits Wallerian degeneration following nerve transection, potentially promoting more rapid recovery of axonal function.

METHODS: An adeno-associated virus plasmid encoded with a dominant-negative SARM1 protein fused with green fluorescent protein to impair SARM1 function, was injected into 24 juvenile rats to create a SARM1 dominant-negative (SARM1-DN) phenotype. Twenty-four control rats were injected with a control plasmid expressing only green fluorescent protein. …

Context-Dependent Contribution Of Peptidyl Arginine Deiminase 4 (Pad4) To Neutrophil Extracellular Trap Formation And Liver Injury In Acute And Chronic Hepatotoxicant Challenge, Gina E Capece, Amish K Patel, Daniel Hu, Tayana Roychowdhury, Bianca Hazel, Jessica Kothapalli, Noah A Mac, Frederik Denorme, Robert A Campbell, Lauren G Poole

2020-Current year OA Pubs

Neutrophils play a complex role in the pathogenesis of chronic liver disease and have been linked to both liver damage and injury resolution. Recent reports propose that neutrophils drive liver injury and fibrosis through the formation of neutrophil extracellular traps (NETs). This study tests the hypothesis that the enzyme peptidyl arginine deiminase-4 (PAD4) drives NET formation and liver fibrosis in experimental chronic liver injury. Wild-type (PAD4+/+) and PAD4-deficient (PAD4-/-) mice were chronically challenged twice weekly with carbon tetrachloride (CCl4, 1 ml/kg, i.p) or vehicle (corn oil) for 6 weeks, and samples were collected 24 h after the final challenge. In …

Plan-B Activist Defense: Defending Animal-Rights Activists In Courtrooms Hostile To Political Argumentation, Hadar Aviram

Faculty Scholarship

In recent years, several animal rights activists faced criminal charges for rescuing animals from factory farms. The standard legal approach in these cases has been relying on the necessity defense, which has a long history in cases of civil disobedience and ideologically driven crime. Animal law scholarship on this topic tends to focus on explaining why the defense applies to open rescue. However, as recent trials have demonstrated, actual courtrooms in rural counties tend to be hostile to the necessity defense, and judges can and do rely on Supreme Court precedent to keep it out of the courtroom.

This Article's …

Upregulation Of Adenosine A2a Receptor In Astrocytes Is Sufficient To Trigger Hippocampal Multicellular Dysfunctions And Memory Deficits, Agathe Launay, Miranda E Orr, Et Al.

2020-Current year OA Pubs

Adenosine is an ubiquitous neuromodulator that ensures cerebral homeostasis. It exerts numerous functions through the activation of G-protein-coupled adenosine receptors (ARs), in particular A

Epigenetic And Genotoxic Effects Of Tritium In Marine Mussels: Comparing Waterborne And Metal-Associated Forms, Maria Florencia Ferreira, Andrew Turner, Mickaël Payet, Olivier Debellemaniere, Christian Grisolia, Veronique Malard, Michael N. Moore, Awadhesh N. Jha

School of Geography, Earth and Environmental Sciences

Tritium (³H), an isotope of hydrogen, is a by-product of the nuclear industry. Decommissioning and normal operations of nuclear facilities can generate tritiated stainless-steel particles (T-SSPs) that could be unintentionally released into the environment. Considering tritium's physicochemical properties and the proximity of nuclear facilities to water bodies, assessing the behaviour and potential effects of these particles in the aquatic environment is imperative. In the present study, marine mussels, Mytilus galloprovincialis, were exposed to: (a) hydrogenated, non-radioactive stainless-steel particles (H-SSPs) (10 mg L⁻¹) (b) T-SSPs (1 and 10 MBq L⁻¹) and (c) tritiated water (HTO) …

Gilbert’S Potoroo And The Fun-Guys: Co-Existing Mycophagous Mammals As Indicators Of Potentially Available Fungal Food Resources, Rebecca J. Quah, James Anthony Friend, Aaron J. Brace, Saul J. Cowen, Robert A. Davis, Harriet R. Mills, Anna J.M. Hopkins

Research outputs 2022 to 2026

Understanding resource use and availability is critical for the success of wildlife translocations, especially for species with complex diets. Mycophagous (fungus-feeding) diets are particularly challenging to study due to the difficulty in identifying fungal species, many of which remain undescribed. Environmental DNA (eDNA) metabarcoding techniques applied to scat samples, offer a promising solution to overcome the limitations of traditional dietary analysis involving microscopic identification of undigested material in scats. This allows for the detailed characterization of fungal composition in the diets of mycophagous species. Here we present results of a dietary study focused on Gilbert’s potoroo (Potorous gilbertii) that also …

The Role Of Fungal Proteases In Bioactive Peptide Production And Analytical Approaches For Tracking Their Activity, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsane Shiferaw Terefe, Michelle L. Colgrave

Research outputs 2022 to 2026

Fungal proteases catalyse site-specific peptide bond cleavage in complex protein matrices, enabling bioactive peptide (BP) release. Accurate monitoring is vital for optimising hydrolysis efficiency, minimising nonspecific proteolysis, ensuring consistent yields, and preserving peptide biofunctionality. While analytical and computational tools are well-established for non-fungal systems, their adaptation to fungal proteases remains exploratory, with no comprehensive evaluation addressing the unique challenges in this field. This review synthesises current knowledge, identifies methodological gaps, and outlines future directions for developing fungi-specific analytical pipelines and computational frameworks for BP discovery. It explores fungal protease families, their roles in intracellular peptide processing, and fungal survival strategies. …

Basal Cell Of Origin Resolves Neuroendocrine-Tuft Lineage Plasticity In Cancer, Abbie S Ireland, Ramaswamy Govindan, Et Al.

2020-Current year OA Pubs

Neuroendocrine and tuft cells are rare chemosensory epithelial lineages defined by the expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets, a feature linked to poor patient outcomes

Arousal As A Universal Embedding For Spatiotemporal Brain Dynamics, Ryan V Raut, Zachary P Rosenthal, Xiaodan Wang, Hanyang Miao, Zhanqi Zhang, Jin-Moo Lee, Marcus E Raichle, Adam Q Bauer, Steven L Brunton, Bingni W Brunton, J Nathan Kutz

2020-Current year OA Pubs

Neural activity in awake organisms shows widespread, spatiotemporally diverse correlations with behavioural and physiological measurements

Exploratory Analysis Of Prerequisites To Teaching Early Perspective Taking In Children With Autism Spectrum Disorder, Zoe Painter

Honors College Theses

The purpose of the current study was to determine the effectiveness of a behavioral intervention package for improving perspective-taking skills in children with ASD and specifically extend previous research focused on teaching the ability to identify what others are experiencing through their senses. Less complex verbal behaviors hypothesized to be prerequisites to this skill were first assessed systematically in three male children with ASD receiving ABA services in a community-based clinic, and then participants were taught to predict behavior according to the sensory experiences of others (e.g. after observing that a man sees a fly in his drink, responding the …

A Glial Circadian Gene Expression Atlas Reveals Cell-Type And Disease-Specific Reprogramming In Response To Amyloid Pathology Or Aging, Patrick W. Sheehan, Stuart B Fass, Darshan Sapkota, Sylvia Kang, Henry C Hollis, Jennifer H Lawrence, Sohui Park, Ashish Sharma, Dorothy P Schafer, Ron C Anafi, Joseph D Dougherty, John D Fryer, Erik S Musiek

2020-Current year OA Pubs

While circadian rhythm disruption may promote neurodegenerative disease, the impact of aging and neurodegenerative pathology on circadian gene expression patterns in different brain cell types remains unknown. Here we used a translating ribosome affinity purification to identify the circadian translatomes of astrocytes, microglia and bulk tissue in healthy mouse cortex and in the settings of amyloid-β plaque pathology or aging. We show that glial circadian translatomes are highly cell-type-specific and exhibit profound, context-dependent reprogramming in response to amyloid pathology or aging. Transcripts involved in glial reactivity, immunometabolism and proteostasis, as well as nearly half of all Alzheimer's disease risk genes, …

Critical Young Consumers: What Types Of Porn Do Teens Watch, And Why?, Giselle Woodley, Marc Zen, Harrison W. See, Lelia Green

Research outputs 2022 to 2026

Pornography use by teens is of growing concern to parents and communities. There is, however, often little differentiation made between the types of contents being consumed or exploration of the types of pornography teens are watching and why. This paper interrogates data collected from 49 qualitative interviews, including 19 follow-up interviews and 4× focus groups with teens. This paper explores teens’ perspectives on the types of pornography accessed by themselves and their peers, and popular categories of pornography more widely. Teens appear to view various types and genres of pornography, as do adults. Some teens prefer ‘ethical’ sources of porn, …

Can Inflammatory Indices Predict Myringosclerosis?, Neslihan Sari, Hasan Basri Savaş, Seda Uğraş, Cengiz Durucu

Saudi Medical Journal

Objectives: To examine the relationships between the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII) in myringosclerosis after ventilation tube insertion (VTI). Methods: We conducted this descriptive case-control study between March 2022 and September 2024. A total of 75 children aged 6 to 12 years with a history of VTI were enrolled. Myringosclerosis+ (n=43) included children with myringosclerosis, while Myringosclerosis- (n=32) included children without myringosclerosis. Preoperative values for NLR, PLR, and SII were collected by hematological testing and calculations. Demographic factors, prognostic risk factors and discrimination power of parameters were determined by statistical methods. Results: …

Comparative Analysis Of Autophagy And Apoptosis Pathways In Viral And Alcoholic Cirrhosis: An Immunohistochemical Study, Gunnur Demircan, Selimcan Berk, Doga Karayilan, Berkay T. Ozgur, Sema Ketenci, Ipek Elbegi, Vildan Karpuz, Melike Yavuz, Ahmet Midi, Demet Akin

Saudi Medical Journal

Objectives: To study the different cellular death mechanisms between viral cirrhosis and alcoholic cirrhosis. The research investigated autophagy and apoptosis mechanisms in hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol-induced cirrhosis. Methods: The research team analyzed biopsy samples from the liver which were obtained at Florence Nightingale Hospitals, Istanbul, Turkey. The experimental protocols were performed between February 2021 and February 2023. The study included 19 HBV, 15 HCV, 13 alcohol-related cirrhosis patients and 6 normal liver tissues. Beclin-1, Caspase-3, Bcl-2 and LC3 expressions were evaluated by immunohistochemistry. Results: Staining intensity as well as extent underwent evaluation through H-score …

The Relationship Of St6gal1 With Clinicopathological And Prognostic Factors In Breast Carcinomas, Ethem Ömeroğlu, Abdülhalim Serden Ay, Tuğba Günler, İlknur Küçükosmanoğlu, Sümeyye Kozacıoğlu

Saudi Medical Journal

Objectives: To investigate the association of β-galactoside α2-6 sialyltransferase 1 (ST6GAL1) expression with hormone receptor (HR), human epidermal growth factor receptor 2 (HER2), and other clinicopathological parameters, including histological grade, stage, lymphovascular invasion, perineural invasion, and survival in breast carcinomas (BCs). Methods: This study included 85 patients who had undergone surgery for breast cancer (BC). The associations of HR, HER2 status, and histopathologic tumor characteristics with immunohistochemical expression of ST6GAL1 were analyzed. Results: The majority (48 [56.5%]) of patients were in the T2 stage, and no association was seen between staging and ST6GAL1 ( p <0.05). Further, 44 (54.2%) patients were HR positive, and most of them exhibited high ST6GAL1 levels ( p =0.001), whereas 44 (51.8%) were HER2 negative, and most of them demonstrated low ST6GAL1 levels ( p =0.007). Ki-67 of ≥20% was observed in 55 (64.7%) and <20% in 30 (35.3%) patients. Most of those with high Ki-67 demonstrated low-grade STLGAL1 expression; however, no correlation was detected between the two values ( p =0.378). High and low ST6GAL1 expressions were observed in 39 (45.9%) and 46 (54.1%) cases, respectively. Conclusion: This research is one of the first studies to use ST6GAL1 in preoperative biopsies of patients not scheduled for neoadjuvant treatment. This study revealed highly significant associations of ST6GAL1 expression with HR, HER2, and molecular subtyping. Future studies are recommended to clarify the possible role of ST6GAL1 in resistance to HR and HER2-targeted and other chemotherapeutic agents in BCs.

Enhancing Concrete Self-Healing Using Wastewater Bacteria Impregnated In Pumice Lightweight Aggregates, Mamoun Alqedra, Kamal El Kahlout, Ahmed El Refai, Mahmoud El Hessi, Muhammad Radwan, Waleed Iky

Mansoura Engineering Journal

Self-healing concrete presents a promising solution to counter the degradation of concrete structures caused by cracks and damage. This innovative mechanism employs the concrete's capacity to autonomously repair its cracks, effectively extending the lifespan of structures and reducing maintenance costs. Particularly in regions facing water scarcity, such as the Middle East and North African countries, the utilization of wastewater holds significant importance. This study investigates the self healing abilities of wastewater bacteria infused into lightweight pumice aggregates within concrete. Wastewater contains diverse bacteria, microorganisms, and oxygen—essential components for the self-healing process. Wastewater sourced from the North Gaza Emergency Sewage Treatment …

Comparative Legal Rhetoric, Lucy Jewel

Kentucky Law Journal

No abstract provided.

The Conversation Canon, Evan C. Zoldan

Kentucky Law Journal

No abstract provided.

Trumping Tradition: Redefining The Family Farmer, Dalton Stanley

Kentucky Law Journal

No abstract provided.

From "Pata Pata" To Come Back, Africa: Miriam Makeba And Her Fight Against Apartheid, 1953-1990, Maddie Heiser

Journal of Undergraduate Research at Minnesota State University, Mankato

Perhaps one of the most notorious periods in African history was that of Apartheid – a system of racial, political, social, and economic discrimination placed upon the non-white majority of South Africa. Beginning in 1948 and lasting until the early 1990s, Apartheid marked a significant transformation in not only African liberation movements but also those happening across the globe, including the Civil Rights Movement in the United States. While the efforts to overcome Apartheid and empower the overall messages of African liberation and solidarity are well-documented, there are several methods of achieving these goals that have been unfortunately overlooked. Figures …

The Student Movement Volume 110 Issue 6: Warming Spirits Through Passion, Service, And Fellowship, Jj Nixon, Kara Shepard, Megan Constantine, Lia Glass, Corinna Bevier, Melanie Webb, Isa Demoraes, Andrew Francis, Samantha Woolford-Hunt, Joey Carrion, Moraya Truman, Madison Vath, Maya Thomas, Sophia Koh, Kaara Harris

The Student Movement V. 110 (2025-2026)

HUMANS

Faith, Friendship, and Purpose: The Spirit of Student Missions, JJ Nixon

VACD Students Experience Communication Conference, Kara Shepard

Finding Her Canvas: Joy Broderick's First-Year Experience at Andrews University, Megan Constantine

ARTS & ENTERTAINMENT

Is Bingeing the Point of Streaming?, Lia Glass

Four Fall Films to Watch This Autumn, Corinna Bevier

Reggie & Ladye Love Smith to Bring Southern Gospel to HPAC, Melanie Webb

NEWS

"Unchanging": AY Service Connects Humility and Growth in God's Word, Isa DeMoraes

Student Movement Archives a Part of Giving Tuesday Initiatives, Andrew Francis

Alumna Discusses Political Threats to Humanities During Campus Lecture Talk, Andrew Francis …

New Frontiers 2024-2025, University Of Nebraska At Kearney Division Of Research And Creative Activity

New Frontiers

New Frontiers 2025 Features:

• Sacred Sounds - Sharon Campbell
• Exploring the Quantum Frontier - EQUATE
• Building Biomedical Excellence - INBRE
• Public History with a Purpose - Will Stoutamire
• Protecting the Nation - NSRI
• Shared Solutions - KNEW

Living Property, Joseph William Singer

Seattle University Law Review

The Supreme Court has increasingly defined property rights that are per se exempt from regulation in the absence of compensation, most recently in Cedar Point Nursery v. Hassid (2021) and Tyler v. Hennepin County (2023). The Court claims that it can identify property rights that are categorically protected from regulation by reference to history, tradition, and precedent. Yet this approach is oddly ahistorical; it is inconsistent with the fact that property law changed dramatically over U.S. history, as well as varying tremendously among the states. It is also inconsistent with the historical context of the Founding era. At that time, …

Fresno’S Scribbles Bike Path: A Master Plan For Active Transportation, Holly Sowles, Uris Giron

Mineta Transportation Institute

The Fresno Scribbles Bike Path Master Plan, which represents a commitment to equitable active transportation and social infrastructure, is designed to enhance the quality of life for Fresno residents by providing safe, comfortable, and accessible biking and walking paths while promoting sustainability and fostering a sense of community. This report details the Intelligent Design Visualization Lab’s (IDVL) ongoing contribution to the Fresno City Scribbles Bike Campus initiative. This multifaceted urban intervention seeks to promote bike and pedestrian safety, enhance environmental resilience, and active transportation infrastructure through design, serving as a form of placemaking. In collaboration with the Fresno State Transportation …

Table Of Contents

Seattle University Law Review

Table of Contents

The Roots Of Credit Inequality, Andrea Freeman

Seattle University Law Review

Debt oppression began before the United States became a country. Settlers enslaved Africans and Indigenous people, treating them as property that they could buy and sell for their economic and personal benefit. When enslavement became illegal, new economic systems and laws that included sharecropping, Black Codes, and Jim Crow kept Black people in servitude. Laws that prohibited enslaved people from owning property or selling goods to white people evolved into restrictions on Black people’s occupations and market participation, both formal and informal. When Black entrepreneurs overcame these obstacles and built wealth within Black business enclaves, white people enforced their racist …

“A Plain Denial”: Reclaiming Equal Protection In American Juvenile Law, Addie C. Rolnick, David S. Tanenhaus, Justin Iverson, Danielle L. Silvestri

Seattle University Law Review

Juvenile courts are based on the premise that children are different from adults and should therefore be treated differently. Children may be treated more informally by courts, punished for different purposes, and brought before the court for different behaviors. Since In re Gault, the Supreme Court has been clear that there are limits to how different juvenile courts can be. Juveniles are entitled to many of the same procedural protections as adult criminal defendants, although the Court has preserved some procedural differences where it has determined that their benefit is outweighed by the need to preserve the informality, flexibility, …

Class Relations And The Law: A Model And Agenda For Research, Brishen Rogers

Law and Contemporary Problems

No abstract provided.

The Scarlet - Volume Civ, No. 4 (October 31, 2025), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The October 31, 2025 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.