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Contents, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Instructions For Authors, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Person-Centered Pluralism About Contract Theory, C. Scott Pryor

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Generative A.I., Virtual Child Pornography, And The First Amendment: Time To Reconsider Ashcroft V. Free Speech Coalition?, Seth Atisha

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

What’S Wrong With Inflicting Death? Evaluating Marquis’S “Future Of Value” Account, Christopher Kaczor

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

The End Is Still To Come: How The Law’S Interaction With Digital Replicas And Derivative Digital Replicas Will Shape The Future, Spencer Kweskin

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

The Case For Climate Refugee Protection, Nicole Theriot

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Loss Of Endogenous Circadian Clock Function In Mice Alters Respiratory Cycle Timing In A Time Of Day- And Sex-Specific Manner, Aaron A. Jones, Deanna M. Arble

Biological Sciences Faculty Research and Publications

Resting breathing and ventilatory chemoreflexes are regulated in a 24-hr manner by the endogenous circadian clock. However, it is unclear how circadian biology influences different phases of the breath-to-breath respiratory cycle which are predominantly controlled by pontomedullary regions of the brainstem. Here, we performed whole-body plethysmography during quiet wakefulness in young adult male and female mice lacking the core clock gene Brain and Muscle Arnt-like 1 (BMAL1) to determine the extent to which the molecular clock affects respiratory cycle timing and ventilatory airflow mechanics. Breath waveform analysis revealed that male BMAL1 knockout (KO) mice exhibit time of day-specific differences in …

Diabetes Potentiates The Emergence And Expansion Of Antibiotic Resistance, John C. Shook, Benjamin P. Darwitz, Kaleb J. Tyson, Amanda Z. Velez, Sophia K. Bridwell, Joshua B. Parsons, Sarah E. Rowe, Christopher Marshall, Brian P. Conlon, Lance R. Thurlow

Biological Sciences Faculty Research and Publications

Individuals with diabetes mellitus frequently develop severe skin and soft tissue infections (SSTIs) that are recalcitrant to antibiotic treatment. We examined how diabetes affects the emergence of antibiotic resistance in a Staphylococcus aureus SSTI. We determined that S. aureus evolves antibiotic resistance rapidly in diabetic mice, while resistance did not occur in nondiabetic mice over the course of infection. Diabetes-associated immune cell dysfunction plays a minor role in the emergence of resistance, while hyperglycemia plays a dominant role facilitating the expansion and takeover of resistant mutants in diabetic infections. Furthermore, vancomycin intermediate resistant isolates display a pronounced fitness defect in …

Editorial: Women In Antimicrobials, Resistance And Chemotherapy: 2023, Cindy Shuan Ju Teh, Krassimira R. Hristova, Ana R. Freitas

Biological Sciences Faculty Research and Publications

No abstract provided.

Continuous Monitoring Of Sterility: Bacterial Contamination And Disinfectant Performance In Dental Clinics, Nathaly Alsalloum, Tarek Aboajwa, Shuaib Alahmad, Nermin Almouhammad

International Arab Journal of Dentistry

Objectives: This study aimed to (1) evaluate contamination levels across three clinics (endodontic, extraction and surgery, and fixed prosthodontics), (2) identify the types and prevalence of bacteria, (3) estimate the effectiveness of a commercial disinfectant, and (4) determine the bacterial species most responsive to the disinfectant.

Methods: Equal surfaces (17.98 cm²) were swabbed, cultured on nutrient agar for the total aerobic microbial count before and after disinfection, and analyzed using settle plates. Bacterial identification was conducted through colony characteristics, Gram staining, and biochemical tests. Data were processed using SPSS version 26.

Results: The endodontic clinic exhibited …

The Association Of Hyperhomocysteinemia (Hhcy) With Cancer Risk: An Updated Systematic Review And Meta-Analysis Of Case-Control Studies (2013-2024), Hajar Heidari

Electronic Theses & Dissertations (2024 - present)

Abstract:

Cancer continues to be one of the leading causes of morbidity and mortality globally, influenced by a complex interplay of genetic, environmental, and nutritional factors. Among these, the metabolism of homocysteine (HCY), a sulfur-containing amino acid derived from dietary methionine, has attracted growing attention due to its involvement in one-carbon metabolism and its potential link to cancer. Elevated HCY levels, a condition known as hyperhomocysteinemia (HHCY), have been shown to disrupt crucial cellular processes such as DNA methylation and promote oxidative stress (OS)—both of which contribute to genomic instability and cancer progression. Disruptions in the folate and methionine cycles, …

Diversity, Genomics And Antimicrobial Resistance Of Coagulase-Negative Staphylococcus: A Literature Review, Kathleen Okeefe

Electronic Theses & Dissertations (2024 - present)

Members of the gram-positive bacterial genus Staphylococcus have historically been classified into coagulase-positive Staphylococcus (CoPS) and coagulase-negative Staphylococcus (CoNS). This classification is based on the ability of clotting of plasma by the coagulase enzyme, which converts fibrinogen to fibrin. CoNS species are ubiquitous commensals that frequently colonize the skin and mucosal surfaces. They are also opportunistic pathogens implicated in many human and animal infections. The evolutionary history of CoNS has generally been overlooked because of the historical lack of recognition for their clinical importance and poor taxonomic sampling. They are often perceived as being less or non-pathogenic, especially compared to …

Antibody-Induced Multicellular Behaviors Of Salmonella Typhimurium, Samantha K. Lindberg

Electronic Theses & Dissertations (2024 - present)

Salmonella enterica is a globally distributed bacterial pathogen that is commonly acquired through consumption of contaminated food and water. The enterica subspecies includes over 1500 unique subvariants, or serovars, that are classified by antigen presentation. Due to its global environmental prevalence, broad host range, and increasing pathogenicity, serovar Typhimurium is of particular concern for human and animal health, as well as food safety. Once in the gastrointestinal tract, Salmonella Typhimurium (STm) exploits host immune mechanisms, implements an arsenal of virulence factors, and outcompetes the microbiota to invade the intestinal epithelium. While STm infections are generally self-limiting and relatively mild, emerging …

A Theoretical And Empirical Adaptation Of Signaling Theory For Digital Communication: Examining Organizational Brand Identity And Credibility, Victoria Barbeisch

Electronic Theses & Dissertations (2024 - present)

This dissertation adapts signaling theory for digital communication and tests its relevance in strategic communication, specifically concerning unobservable organizational traits like brand identity values. Signaling theory explains how parties with unequal information (senders/signalers and receivers) use signals to bridge knowledge gaps and influence decision-making. While rooted in biology and economics, its application in computer-mediated communication (CMC) remains limited. This research addresses this gap through two primary aims. Aim 1 presents the first comprehensive theoretical adaptation of signaling theory for digital communication, consolidating fragmented research across multiple disciplines. Aim 2 investigates the theory's relevance in strategic communication related to unobservable brand …

Wide Band Gap Halide Perovskite, Miranda Bristol

Electronic Theses & Dissertations (2024 - present)

This thesis investigates the composition of alloyed materials required to stabilize cubic halide perovskites, aiming to offer a viable alternative to the commonly used oxides and lead-based perovskite wide band gap materials. This research aimed to identify materials that exhibit comparable or superior optoelectronic properties while minimizing geopolitical risks associated with critical materials. A wide band gap semiconductor, with a band gap larger than 2 eV, allows for more outstanding thermal and voltage stability and can absorb in the UV to the visible spectrum. The perovskite proposed in this study, CsSn_0.975Zn_0.025Cl₃, demonstrates promising potential …

Adaptive Evolution Shapes The Transmissibility Of West Nile Virus In New York State, Sean M. Bialosuknia

Electronic Theses & Dissertations (2024 - present)

Arthropod-borne viruses (arboviruses), which are maintained in nature in complex transmission cycles involving hematophagic invertebrates and their vertebrate hosts, are the cause of a significant and expanding global health burden. Defining arbovirus-host interactions is necessary if we are to understand the adaptive and epidemiological potential of arboviruses. The results presented with West Nile virus (WNV Flaviviridae: Orthoflavivirus), are a compilation of such studies. WNV is the most prevalent arboviral pathogen in the U.S. and the most geographically distributed arbovirus in the world. Despite the evolutionary potential of these RNA viruses, WNV and other arboviruses have experienced only limited …

Divided By Fear: The Influence Of Political Beliefs On The Perception Of Extremist Groups, Hannah A. Scott

Electronic Theses & Dissertations (2024 - present)

Acts of violent extremism and support for political violence have increased in the United States over the past decade. Previous studies have primarily focused on the differences in risk perception between White Supremacists and Islamic Extremists/Jihadists, neglecting other ideological movements. This study utilizes data from the fifth wave of the Chapman Survey of American Fears and employs ordinal logistic regression to compare the fear of seven different extremist groups and movements: Islamic Extremists/Jihadists, the Militia/Patriot Movement, White Supremacists, Extreme Environmentalists, Extreme Animal Rightists, Anti-Immigration Groups, and ANTIFA. The findings reveal notable differences across political parties (Democrats, Republicans, and Independents) and …

Worldbuilding A Queer Before: D&D As A Neomedievalism For A Modern Age, Brianna M. Thompson

Electronic Theses & Dissertations (2024 - present)

Dungeons & Dragons (D&D) has had countless participants and audience members in the course of its over fifty-year existence. It has also been the subject of several studies that attempt to capture its unique form of performative play. Yet, there has been a scarcity of scholarship on how D&D acts as a neomedievalism and how that can offer a queer kind of opportunity to its players, allowing them to find a place in a past that is historically inaccessible and yet endlessly in the process of being (re)imagined. Using an interweaving of archival theory with queer and performance studies, particularly …

Elucidating The Effects Of Environmental And Physiological Conditions On Stem Cell Regulation In Vivo, Nimmy John

Electronic Theses & Dissertations (2024 - present)

The Notch signaling pathway is a highly conserved intercellular signaling pathway that any dysregulation can lead to a variety of human diseases. These diseases are further exacerbated by various environmental, pathological and genetic conditions. Previous studies have shown that these conditions have been known to affect the Notch transcriptional response. However, the molecular mechanisms by which such conditions influence Notch signaling remained largely unknown. Moreover, most Notch studies have relied on in vitro systems and indirect reporters, which can miss the dynamic and contextual nature of Notch signaling. Here, we systematically analyzed the effects of these conditions with single molecule …

“A ‘Normal’ Life”: Red Dwarf, Temporality, And The Neuroqueer Absurd, Gretchen B. Graf

Electronic Theses & Dissertations (2024 - present)

The science fiction series Red Dwarf, beginning in 1988 and broadcasting sporadically over the past nearly four decades, takes place more than three million years in the future where human beings have gone extinct. All, that is, except one; the show’s central character, Dave Lister, is the last known living human being in the universe, outliving humanity by remaining in stasis during a radiation leak that killed the rest of the crew of the titular mining ship. Besides Lister, the narrative also focuses on the nonhuman beings that keep him company. Besides residing in the genre of science fiction, …

Emergent Sites Of Language Contact: Lexical Borrowing By Mexican Bilingual Speakers In Live-Streamed Tabletop Games, Ethan Sims

Electronic Theses & Dissertations (2024 - present)

The field of contact linguistics has investigated numerous sites of contact between languages and the resulting phenomena (Poplack et al.; 1988, for example); however, there remain many contact sites that have yet to be analyzed. The present dissertation views the lexical evidence of language contact between English and Spanish via the medium of live-streamed tabletop role-playing games. These games, often lacking accessible translations in languages other than English, have become a popular pastime over the last decade, which has increased the amount of contact between the two languages. Dungeons and Dragons, a roleplaying game which typically deals with fantasy elements, …

The Maritime Archaic Occupation Of The Stock Cove Site (Ckal-3), Newfoundland, Canada, Dana M. Keil

Electronic Theses & Dissertations (2024 - present)

The Stock Cove site (CkAL-3), located on the southeastern coast of Newfoundland, is an archaeologically rich multi-component site. The Maritime Archaic (ca. 8,000-3,200 BP) culture was the earliest people to inhabit the island of Newfoundland and the Stock Cove site, settling the island by at least 6,400 years ago. Their ability to maintain lithic traditions was key to their success. Finding new sources of lithic material would have been necessary and that process would have varied greatly across the island. In southeastern Newfoundland, far away from key lithic sources on the mainland, this would have been even more important as …

Phantasma, Grace Wright

Electronic Theses & Dissertations (2024 - present)

Ever since the infamous Ides of March, scholars have been debating the true psychology behind Brutus’s betrayal. The purpose of this project is to take a step back from the politicized motivations and explore the emotional, strenuous conditions of Julius Caesar’s assassination. This project will transform William Shakespeare’s Julius Caesar into a novella with its central focus on the relationship dynamics between the key figures of Caesar, Brutus, and Cassius. The intention of the novella is to not only analyze the play through a critical queer lens, but to interrogate the themes of violence and desire that surround male relationships …

Diversity Within Species: Mechanisms, Evolution And Implications In Bacterial Disease, Kathryn R. Piper

Electronic Theses & Dissertations (2024 - present)

The Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacterium Escherichia coli are ubiquitous commensal and opportunistic pathogens. In humans, S. aureus is commonly found on the skin and mucus membranes, and is known to cause infections in the skin, bloodstream and brain. E. coli is a normal part of the gut microbiota in humans and can cause intestinal and extraintestinal infections alike. S. aureus and E. coli pose global threats to public health, due to the high morbidity and mortality of invasive strains. The wide range of infections they cause in humans and other animals are exacerbated by the presence …

Utilizing Technology To Support Collaborative Problem-Solving Of K-12 Students In Stem Education: A Multivariate Multi-Level Meta-Analysis, Marzieh Dehghan-Chaleshtori

Electronic Theses & Dissertations (2024 - present)

As classrooms in the 21st -century increasingly incorporate digital tools, educators and researchers have turned their attention to the promising potential of technology in enhancing essential competencies such as collaborative problem-solving (CPS) skills (OECD, 2017). CPS skills, including joint decision-making and coordinated problem resolution, are necessary for success in both academic and real-world contexts. While many studies have investigated individual problem-solving in technology-enhanced learning environments, the collaborative dimension remains underexplored (Graesser et al. 2018b). This dissertation addresses that gap by conducting a multivariate multi-level meta-analysis to examine the overall effects of technology use on K–12 students’ CPS skills in STEM …

Self-Preservation: Autobiography As A Form Of Archivization As Seen Through The Life And Poetic Works Of John Clare, Meghan J. Slaff

Electronic Theses & Dissertations (2024 - present)

This paper will look at how the processing efforts of an archivist mirror that of an autobiographer through the shared motivation of adding to the cultural memory or textual canon of a society. For archival purposes, the typical steps of ingesting, preparing, and presenting a collection are creation, capture, arrangement/description, and pluralization. To create an autobiography, writers take the memories that have been created and experienced due to events in their lives and capture those memories via recording in the literary form known as autobiography. These autobiographers then arrange and describe their memories in a way that shows vast similarities …

Phylogenetic Analysis Of Metabolic Enzymes In Hypoxic/Anoxic Conditions In Cetaceans And Cancer, Samerna A. Masih

Electronic Theses & Dissertations (2024 - present)

Cancer cells often exhibit a Warburg-like metabolism, which includes increased fatty acid synthesis and storage that help them survive in hypoxic conditions. This shift is marked by the heightened synthesis and accumulation of fatty acids, acting as a survival mechanism in low-oxygen environments (Baumann et al., 2016). Interestingly, deep-diving whales may utilize a similar metabolic pathway to produce wax esters during their prolonged dives.

Our study focused on exploring the genetic and metabolic similarities between breast cancer cells and deep-diving whales, using computational analyses to investigate lipid metabolism genes. We looked for evolutionarily conserved variations that might reveal adaptive mechanisms …

Ribosome Hibernation In Mycobacterium Abscessus And Its Effect On Antibiotic Resistance, Ryan Treen

Electronic Theses & Dissertations (2024 - present)

Non-tuberculosis mycobacteria (NTM) represent a diverse repertoire of species, most of which are ubiquitous in the environment. Some NTM species, such as Mycobacterium abscessus, can cause life-threatening infections in people with underlying medical conditions. The clinical incidence of such infections is on the rise, posing an emerging threat to public health. M. abscessus is characterized by intrinsic and acquired antibiotic resistance, complicating treatment strategies. Most chemotherapeutic approaches for M. abscessus infection target the bacterial ribosome, necessitating a better understanding of the physiological processes which confer this resistance. Multiple mycobacterial species respond to zinc-limiting conditions by inducing remodeling and hibernation …

School Contexts And The Construction Of Literacy Practices And Identities Among Middle School Students Of Color, Eugene K. Gyekye

Electronic Theses & Dissertations (2024 - present)

This dissertation investigates how middle school students of color construct and negotiate their literacy identities within an urban public school's institutional, classroom, and online contexts. The study is situated at Oakville Middle School, a culturally and linguistically diverse setting that reflects the complexities of adolescent literacy education in contemporary urban environments. The research explores how students' literacy practices are shaped by their interactions with school structures, pedagogical approaches, peer dynamics, and digital platforms and how these experiences influence their development as literate individuals.

The study responds to the persistent challenge of educational inequity, particularly the disconnect between students' cultural identities …