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Middle Level English Learners’ Engagement With Digital Multimodal Resources And Each Other, Mark Stevens
Middle Level English Learners’ Engagement With Digital Multimodal Resources And Each Other, Mark Stevens
Intersections: Critical Issues in Education
Students in schools who speak multiple languages need opportunities for multimodal learning. A study was conducted to observe how middle level English Learners used multimodal (text, audio, video, imagery) resources in a Language Arts - Social Studies class. The research question was: What patterns of engagement with content, and each other, were manifest by middle level ELs while using multimodal resources in a general education history class? Qualitative case study was used to observe student work and interaction, inspect work artifacts, and interview for opinions and motivations. To learn multimodally, students (a) used approaches (whole class, small group, partner) that …
Pet-Aware Navigation Using Aggregated And Verified Point-Of-Interest Data, Kshitij Suresh Gaikar, Pushkar Mittal
Pet-Aware Navigation Using Aggregated And Verified Point-Of-Interest Data, Kshitij Suresh Gaikar, Pushkar Mittal
Defensive Publications Series
Digital mapping applications may lack integrated data on pet policies for points of interest (POIs), which can lead users to consult fragmented and potentially inaccurate external sources when planning travel with pets. A system and method are described for integrating pet-compatibility data into a navigation application. The system can utilize a multi-source data engine to aggregate and harmonize information from sources such as crowdsourced user reports, third-party data providers, and artificial intelligence analysis of public web data. A harmonization framework may use confidence scoring and a rules engine to resolve data conflicts and verify the pet policies of POIs, such …
Recent Advances In The Synthesis And Pharmacological Profiling Of Pyrazolo[1,5-A]Pyrimidine Derivatives, Wesam S. Shehab, Seham Abdel-Shafi, Mostafa I. Abdelglil, Sabry Shehata
Recent Advances In The Synthesis And Pharmacological Profiling Of Pyrazolo[1,5-A]Pyrimidine Derivatives, Wesam S. Shehab, Seham Abdel-Shafi, Mostafa I. Abdelglil, Sabry Shehata
Al-Farahidi Biomedical Journal
An important class of fused heterocyclic compounds, pyrazolo[1,5-a] pyrimidines have a variety of biological activities, such as anticancer, antimicrobial (antibacterial, antifungal, and antiviral), and enzyme-inhibitory effects. Additionally, it improves the body’s antioxidants and lowers the risk of diabetes. The synthesis and reactivity of distinct pyrazolopyrimidine derivatives using various cyclization and condensation techniques are the main topics of this study. To comprehend these compounds’ function in biological activity, their structural characteristics were thoroughly examined. The chemical pathways, reaction circumstances, and structural alterations that affect their pharmacological potential were highlighted. Pyrazolo[1,5-a] pyrimidines and their derivatives have potential uses in medicinal chemistry—particularly in …
Faculty Senate Agenda December 1, 2025, Utah State University
Faculty Senate Agenda December 1, 2025, Utah State University
Faculty Senate & Faculty Senate Executive Committee
- 3:00 Call to Order
- Approval of Minutes - November 3, 2025
- 3:05 University Business
- 3:20 Faculty Senate Business
- 3:30 Information
- EPC Report - November 6, 2025
- 3:45 Report
- Honors Program Annual Report
- USUSA Annual Report
- Faculty Evaluation Committee
- Academic Freedom and Tenure
- 4:10 Old Business
- 4:15 New Business
- Faculty Forum
- Adjourn: 4:30 pm
The Influence Of Muskrats On The Biodiversity Of Wetlands, Emma Thornton
The Influence Of Muskrats On The Biodiversity Of Wetlands, Emma Thornton
Biology Student Scholarship
Wetlands are one of the most productive ecosystems in the world and are home to various plant and animal species. The relationships between the species living in the wetlands keep the ecosystem functional as well as increasing biodiversity. Increased biodiversity of wetlands creates more resilient plant communities. Muskrats are ecosystem engineers, meaning that they alter their surroundings to change the quality and quantity of the available resources through behaviors related to their eating habits and their burrow construction. Muskrats are herbivores and consume large amounts of vegetation, which creates opportunities for more plant species by creating new ecological niches. In …
Divorcees’ Experiences Of Hubristic Pride In Communication In Previous Marital Relationships, Amanda Harms
Divorcees’ Experiences Of Hubristic Pride In Communication In Previous Marital Relationships, Amanda Harms
Walden Dissertations and Doctoral Studies
Poor communication practices have significantly strained marital relationships, contributing to increased divorce rates in the United States. As a self-conscious emotion, hubristic pride often leads to poor communication, which in turn exacerbates marital discord and contributes to the breakdown of families. The purpose of this basic qualitative study was to explore how divorcees perceive the impact of hubristic pride on communication in their previous marriages. The theoretical framework underpinning this study was Homans’s social exchange theory. Data were obtained from eight divorced participants not actively involved in ongoing custody proceedings through semistructured interviews and analyzed using Saldaña’s descriptive coding methodology. …
Grey Wolf Optimization Of Pi Controller For Power Management In Wind Farms: A Novel Approach, Anis Feddaoui, Lotfi Farah, Abdelouahab Benretem, Mohammed Abdeldjalil Djehaf
Grey Wolf Optimization Of Pi Controller For Power Management In Wind Farms: A Novel Approach, Anis Feddaoui, Lotfi Farah, Abdelouahab Benretem, Mohammed Abdeldjalil Djehaf
Turkish Journal of Electrical Engineering and Computer Sciences
This study proposes a novel power management strategy for wind farms using a grey wolf optimization (GWO)-based PI controller. The method aims to enhance active and reactive power control in systems employing dou bly fed induction generators. Three control strategies are evaluated—namely, a classical frequency-domain PI controller, an Artificial Neural Network (ANN)-based controller, and the proposed GWO-based PI controller—the last of which represents the main contribution. The classical PI and ANN controllers are included strictly for comparative bench marking. MATLAB simulations demonstrate that the GWO-beased PI controller offers superior dynamic performance, particularly in settling time and overshoot reduction. A power …
Stra8 Links Neuronal Activity To Inhibitory Circuit Protection In The Adult Mouse Brain., Ming Huang, Shuwen Yue, Xiaoyu Zhang, Lan Wu, Jay L. Vivian, Zi-Jun Wang, Ning Wang
Stra8 Links Neuronal Activity To Inhibitory Circuit Protection In The Adult Mouse Brain., Ming Huang, Shuwen Yue, Xiaoyu Zhang, Lan Wu, Jay L. Vivian, Zi-Jun Wang, Ning Wang
Manuscripts, Articles, Book Chapters and Other Papers
While neuronal activity is essential for brain function, it also poses threats to neuronal integrity. Here, we show that activity-induced expression of stimulated by retinoic acid gene 8 (Stra8) protects neurons from degeneration. Previously considered germline specific, Stra8 is expressed in the adult mouse brain and is induced by neuronal activity via calcium influx and N-methyl-D-aspartate (NMDA) receptor signaling. Neuron-specific Stra8 knockout mice display hallmark features of neurodegeneration, including DNA damage, impaired proteostasis, inflammation, nuclear envelope erosion, reduced dendritic plasticity, memory deficits, and heightened excitotoxic vulnerability. Electrophysiological studies reveal disrupted inhibitory circuit function. Mechanistically, Stra8 binds regulatory regions of neuromodulator …
Trade Dependency And Resilience: An Analysis Of Egypt’S Wheat Import Dynamics During The Russia-Ukraine War, Maha Elhini, Jomana M. Eiisa, Rasha Hammam
Trade Dependency And Resilience: An Analysis Of Egypt’S Wheat Import Dynamics During The Russia-Ukraine War, Maha Elhini, Jomana M. Eiisa, Rasha Hammam
Economics
Purpose
Provided that Egypt is the world’s largest wheat importer, the conflict between its primary suppliers presents significant challenges to its trade stability and food security. This paper aims to investigate the impacts of the Russia–Ukraine (RU) war on Egypt’s trade dynamics, with a particular focus on wheat imports over the period 1995–2023.
Design/methodology/approach
The study uses the Fully Modified Ordinary Least Squares (FMOLS) model to estimate the relationship between macroeconomic variables and Egypt’s trade performance, as well as agricultural determinants and wheat import dynamics.
Findings
The empirical results show that Egypt’s GDP growth rate and its exchange rate have …
Improving Dynamic Balance And Gait Adaptation With Ischemic Conditioning Post-Stroke, Stephanie Christine Wolfe
Improving Dynamic Balance And Gait Adaptation With Ischemic Conditioning Post-Stroke, Stephanie Christine Wolfe
Dissertations (1934 -)
The purpose of this dissertation was to quantify the benefits of ischemic conditioning on reactive balance responses and gait adaptation during treadmill walking in chronic stroke survivors. Reactive balance and gait adaptations are believed to be limited in this population. Ischemic conditioning is an emerging adjunct to physical therapy that improves motor function post-stroke via improvements in strength, voluntary muscle activation, walking speed, and fatigability. Here, we quantified how ischemic conditioning could impact performance of a more complex task: altering gait to meet various perturbing conditions. Specifically, we quantified mediolateral margin of stability in response to lateral cable pulls (both …
Volume 13, Number 1, 2023, Volume 13, Number 1, 2023
Volume 13, Number 1, 2023, Volume 13, Number 1, 2023
Perspectives in the Arts and Humanities Asia
No abstract provided.
Three Translations, Soledad S. Reyes
Three Translations, Soledad S. Reyes
Perspectives in the Arts and Humanities Asia
No abstract provided.
Ilang Retrospektibo At Pagpapalawig Sa Kaisipang Reyes Hinggil Sa Aralín At Pagtuturo Ng Kulturang Popular Ngayon, Louie Jon A. Sánchez
Ilang Retrospektibo At Pagpapalawig Sa Kaisipang Reyes Hinggil Sa Aralín At Pagtuturo Ng Kulturang Popular Ngayon, Louie Jon A. Sánchez
Perspectives in the Arts and Humanities Asia
Layon ng sanaysay na ito na maghain ng retrospektibo o, wika nga ni Soledad S. Reyes, “balik-tanaw” sa dalawa niyang sanaysay na matatagpuang pampinid sa Pagbasa ng Panitikan at Kulturang Popular: Piling Sanaysay, 1976–1996 (1997) at sa pinatnugutan niyang teksbuk na Katha (1992) para sa Pamantasang Ateneo de Manila noong dekada 1990. Ang mga ito ay mahalagang pagtatala at pagninilay ng pangunahing iskolar ng kulturang popular sa Filipinas hinggil sa kaniyang mga kaisipan sa aralín at pagtuturo ng kulturang popular. Sa mga akda ring nabanggit, pinahahalagahan niya ang animasyon ng saliksik hinggil sa kulturang popular sa pedagohiya o pagkasangkapan sa …
Rapid Epigenetic Response To Salinity Stress In An Invasive Mussel, Mytilus Galloprovincialis, Andrzej Furman, Açelya Eren, İbrahi̇m Raşi̇t Bi̇lgi̇n, Hati̇ce Aygün Karaçay
Rapid Epigenetic Response To Salinity Stress In An Invasive Mussel, Mytilus Galloprovincialis, Andrzej Furman, Açelya Eren, İbrahi̇m Raşi̇t Bi̇lgi̇n, Hati̇ce Aygün Karaçay
Turkish Journal of Zoology
The Mediterranean blue mussel (Mytilus galloprovincialis) is a well-known invasive species recognized for its remarkable ability to tolerate a wide range of environmental conditions. Here, we investigated DNA methylation changes in M. galloprovincialis exposed to a rapid water salinity decrease. Methylation profiles in M. galloprovincialis were recorded before salinity stress was applied (at 35‰), and then at 3, 9 and 24 h following the stress (at 25‰). We monitored these changes using the methylation-sensitive amplification polymorphism (MSAP) method. Methylation levels continued to vary over the 24 h period following stress exposure, indicating that the underlying physiological processes may have changed …
Phylogenetics Of Cyrtodactylus In West Nusa Tenggara: A New Distribution Record Of Cyrtodactylus Jatnai From Lombok Island And A Cryptic Species From Sumbawa Island, Sandra Rafika Devi, Rury Eprilurahman, Tuty Arisuryanti, Yuliadi Zamroni, Imran Sadewo, Windi Edriyanti, Maulana Faiz Ilham Kholiq, Evelyn Elvira
Phylogenetics Of Cyrtodactylus In West Nusa Tenggara: A New Distribution Record Of Cyrtodactylus Jatnai From Lombok Island And A Cryptic Species From Sumbawa Island, Sandra Rafika Devi, Rury Eprilurahman, Tuty Arisuryanti, Yuliadi Zamroni, Imran Sadewo, Windi Edriyanti, Maulana Faiz Ilham Kholiq, Evelyn Elvira
Turkish Journal of Zoology
Cyrtodactylus is one of the most diverse vertebrates of the Gekkonidae family, first described by Gray in 1827 and widely distributed in Asia, Northern Australia, and the Pacific Islands including Wallacea. The biodiversity in West Nusa Tenggara—a region in Wallacea—has been underestimated despite high fauna endemicity. Conservation strategies are needed to maintain the stability of Cyrtodactylus populations in their habitat. Therefore, this study aims to enhance the understanding of cryptic species and potential new distribution records of the genus Cyrtodactylus in West Nusa Tenggara. Molecular character identification was carried out by isolating the ND2 gene in liver tissue using polymerase …
Bathyal Gastropod (Mollusca) Species From The Turkish Levantine And Aegean Seas, Bi̇lal Öztürk
Bathyal Gastropod (Mollusca) Species From The Turkish Levantine And Aegean Seas, Bi̇lal Öztürk
Turkish Journal of Zoology
This study assigns 35 gastropod specimens and 23 shells collected from two sites on the Turkish Levantine and Aegean coasts at depths of 432 and 702 m, respectively, to 13 species. Among the species identified, Alvania subsoluta (Aradas, 1847), Protatlanta souleyeti (Smith, 1888), Pagodula echinata (Kiener, 1839), Pleurotomella gibbera Bouchet & Warén, 1980, Ringicula gianninii Nordsieck, 1974 and Diaphana marshalli (Sykes, 1904) are new records for the Turkish molluscan fauna; Anatoma aspera (Philippi, 1844) and Acteon monterosatoi Dautzenberg, 1889 are new records for the Levantine coast of Türkiye; and Crenilabium exile (Jeffreys, 1870) is a new record for the Turkish …
Spartan Daily, November 25, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, November 25, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, 2025
Volume 165, Issue 39
Targeting The Hepatic Circadian Clock Concomitant With Tyrosine Kinase Inhibition Reverses Late-Stage Hepatocellular Carcinoma, Baharan Fekry, Savera Aggarwal, Rachel Van Drunen, Rafael Bravo, Andy Escalante, Constance Atkins, Sheng Pan, Zheng Chen, Kai Sun, David R Hall, Mamoun Younes, Kristin Eckel-Mahan
Targeting The Hepatic Circadian Clock Concomitant With Tyrosine Kinase Inhibition Reverses Late-Stage Hepatocellular Carcinoma, Baharan Fekry, Savera Aggarwal, Rachel Van Drunen, Rafael Bravo, Andy Escalante, Constance Atkins, Sheng Pan, Zheng Chen, Kai Sun, David R Hall, Mamoun Younes, Kristin Eckel-Mahan
Faculty, Staff and Student Publications
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths. Most patients present at advanced stages, and the effectiveness of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors is constrained by limited patient response. A subset of HCC shows elevated expression of the promoter 2 ("P2")-driven hepatocyte nuclear factor 4 alpha (HNF4α) isoform, which directly transcriptionally represses the circadian brain and muscle ARNT-like protein 1 (BMAL1) transcription factor. This subtype of HCC is robustly inhibited by the plant-based flavonoid nobiletin (NOB), a circadian-fortifying compound. Using patient-matched human HCC and serum, we show that BMAL1-deficient HCC shows exaggerated carnitine palmitoyl transferase …
The Effects Of Montelukast Sodium On Some Biological And Biochemical Aspects, Dna Damage In Drosophila Melanogaster Adults, Ci̇hat Çeli̇k
The Effects Of Montelukast Sodium On Some Biological And Biochemical Aspects, Dna Damage In Drosophila Melanogaster Adults, Ci̇hat Çeli̇k
Turkish Journal of Zoology
Montelukast sodium (MS) is a leukotriene receptor antagonist and used clinically as an antiasthma agent. MS has been hypothesized to have adverse effects in insects. To test this hypothesis, MS was added to the artificial diet of the fruit fly Drosophila melanogaster Meigen (Diptera: Drosophilidae) at different concentrations (1200, 1600, 2000, and 2400 mg/L) under laboratory conditions. The effects of MS on the survival rate and development time of D. melanogaster, as well as its effects on malondialdehyde (MDA) levels and cytochrome P450 monooxygenase (CYP450) enzyme activity in adults were investigated. The genotoxic effect of MS in whole adults was …
Ecotoxicological Assessment Of A Sunscreen-Derived Pollutant, Benzophenone-2, On Freshwater Fish (Labeo Rohita), Mina Jamil, Sajid Abdullah, Maham Riaz, Sana Aziz
Ecotoxicological Assessment Of A Sunscreen-Derived Pollutant, Benzophenone-2, On Freshwater Fish (Labeo Rohita), Mina Jamil, Sajid Abdullah, Maham Riaz, Sana Aziz
Turkish Journal of Zoology
Ultraviolet filters (UVFs) are constituents of skincare products that protect skin against UV ray damage, such as suntan, sunburn, and skin tumors. Due to their ability to biotransform, UVFs are considered emerging pollutants. Benzophenone-2 (BP-2), with a yellowish crystalline appearance, is one of the widely used UVFs in skincare products. It enters the aquatic environment by washing off the skin during swimming and recreational activities and becomes hazardous to aquatic life due to its lipophilicity and bioaccumulative potential. This study was designed to evaluate the acute and chronic toxicity of BP-2 for the freshwater fish Labeo rohita. For acute toxicity, …
Morphological Variability And Systematics Of Ponto-Caspian Cladocerans Of The Genus Cercopagis Sars, 1897 (Branchiopoda: Onychopoda: Cercopagidae), Larisa F. Litvinchuk, Spartak N. Litvinchuk
Morphological Variability And Systematics Of Ponto-Caspian Cladocerans Of The Genus Cercopagis Sars, 1897 (Branchiopoda: Onychopoda: Cercopagidae), Larisa F. Litvinchuk, Spartak N. Litvinchuk
Turkish Journal of Zoology
In recent decades, significant changes have occurred in the composition of zooplankton, especially in the Ponto-Caspian Basin. An important component of zooplankton in this region is cladocerans of the genus Cercopagis. However, the introduction of invasive species means that many species of this genus have probably become extinct. Because their disappearance molecular study of these organisms is no longer possible. Therefore, a comparative analysis of morphological variability has become more important. We studied the morphological variability of all 12 currently known species of the genus. Samples from the Caspian, Azov, Black, and Baltic Seas were analyzed. The number of species …
The Current Of Anxieties: Ghosts And Capital For The Liminal Bride In Hiroko Oyamada’S The Hole, Maliha Kabir
The Current Of Anxieties: Ghosts And Capital For The Liminal Bride In Hiroko Oyamada’S The Hole, Maliha Kabir
Electronic Theses and Dissertations 2020 - Present
This thesis offers a reading of Hiroko Oyamada’s The Hole as discourse surrounding modern neoliberalism’s dissolution and transformation of boundaries between socio-political domains, such as the public/private, and its consequent effects on individual subjectivity and interpersonal relationships. Within the novella’s depictions of the mundane, I also seek to argue that Oyamada’s employment of the liminal, through distortions of space and time, is used to depict the precarity of marginalization as an always present force due to the pervasiveness of capitalism, but purposefully hidden to maintain security in illusion.
Mitochondrial Iron Transport Via Mfrn1 Is Required For Erythroid Cell Cycle Progression, Mark Perfetto, Aidan Danoff, Muhammad Ishfaq, Heidi Monroe, Aiden Mohideen, Meilin Chen, Jesus Tejero, Amber N Stratman, Satoshi Okawa, Yvette Y Yien
Mitochondrial Iron Transport Via Mfrn1 Is Required For Erythroid Cell Cycle Progression, Mark Perfetto, Aidan Danoff, Muhammad Ishfaq, Heidi Monroe, Aiden Mohideen, Meilin Chen, Jesus Tejero, Amber N Stratman, Satoshi Okawa, Yvette Y Yien
2020-Current year OA Pubs
Iron metabolism drives key erythropoietic processes, including hemoglobinization, survival, and proliferation. Here, we developed in vivo methods to interrogate how iron regulates erythropoiesis and report that mitochondrial iron transport via mitoferrin-1 (MFRN1) is essential for erythroid cell cycle progression. mfrn1 embryos had severely decreased erythroid cell number caused by cell cycle arrest at G2/M. They had enlarged nuclei, suggesting a mitotic defect. Iron supplementation rescued the cell cycle defect, implicating mitochondrial iron deficiency as its cause. In contrast, fpn1 mutants, anemic from systemic iron deficiency, had less severe decreases in erythroid mitochondrial iron than mfrn1 mutants and no proliferative defects. …
Preserve The Harvest: Canning Goat Meat At Home, Callie Adams, Andrea Schmutz
Preserve The Harvest: Canning Goat Meat At Home, Callie Adams, Andrea Schmutz
All Current Publications
Due to its lean composition and nutritional profile similar to those of other tested meats, goat is well-suited for pressure canning. Follow USDA and Utah State University (USU) Extension altitude guidelines. This fact sheet provides guidelines for selecting high-quality meat, using proper equipment, and adhering to tested methods. Home canners can safely preserve goat meat and enjoy its benefits year-round.
Nivolumab Plus Ipilimumab Induce Hyper-Progression In Renal Medullary Carcinoma: Results Of A Phase Ii Trial And Preclinical Evidence, Melinda Soeung, Xinmiao Yan, Ciro Zanca, Jing Qian, Menuka Karki, Fei Duan, Hania Khan, Li Zhang, David H Peng, Mariah Williams, Rong He, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca S Tidwell, Pankaj K Chauhan, Courtney N Le, Truong N A Lam, Nirjar Bhattacharya, Rutvi Shah, I-Lin Ho, Jason P Gay, Caroline C Carrillo, Ningping Feng, Kang Le, Guang Gao, Teresa L Perry, Faika Mseeh, Yongying Jiang, Quanyun A Xu, Niki Marie Zacharias, Rahul A Sheth, Tharakeswara K Bathala, Priya Rao, Najat C Daw, Durga N Tripathi, Cheryl L Walker, Mohammad M Mohammad, Jianhua Zhang, Guangchun Han, Yanshuo Chu, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya Jadhav, Wenhua Lang, Claudio A Arrechedera, Leticia Campos Clemente, Edwin R Parra, Hsinyi Lu, Cara L Haymaker, Ignacio I Wistuba, Andrew Futreal, Andrea Viale, Michael J Soth, Philip Jones, Joseph R Marszalek, Timothy Heffernan, Giulio F Draetta, Nizar M Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel
Nivolumab Plus Ipilimumab Induce Hyper-Progression In Renal Medullary Carcinoma: Results Of A Phase Ii Trial And Preclinical Evidence, Melinda Soeung, Xinmiao Yan, Ciro Zanca, Jing Qian, Menuka Karki, Fei Duan, Hania Khan, Li Zhang, David H Peng, Mariah Williams, Rong He, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca S Tidwell, Pankaj K Chauhan, Courtney N Le, Truong N A Lam, Nirjar Bhattacharya, Rutvi Shah, I-Lin Ho, Jason P Gay, Caroline C Carrillo, Ningping Feng, Kang Le, Guang Gao, Teresa L Perry, Faika Mseeh, Yongying Jiang, Quanyun A Xu, Niki Marie Zacharias, Rahul A Sheth, Tharakeswara K Bathala, Priya Rao, Najat C Daw, Durga N Tripathi, Cheryl L Walker, Mohammad M Mohammad, Jianhua Zhang, Guangchun Han, Yanshuo Chu, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya Jadhav, Wenhua Lang, Claudio A Arrechedera, Leticia Campos Clemente, Edwin R Parra, Hsinyi Lu, Cara L Haymaker, Ignacio I Wistuba, Andrew Futreal, Andrea Viale, Michael J Soth, Philip Jones, Joseph R Marszalek, Timothy Heffernan, Giulio F Draetta, Nizar M Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel
Faculty, Staff and Students Publications
Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here we report the results of a phase II clinical trial (NCT03274258) of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in patients with RMC, with objective response rate as primary outcome. Enrollment was halted for futility at a prespecified interim analysis as all 10 treated patients experienced rapid disease progression. 5/10 met radiological criteria for hyperprogression and median progression-free survival (secondary outcome) was 1.38 months (95% confidence interval: 1.28, 1.60). In a post-hoc single-cell RNA sequencing analysis, data from patients with RMC before and after nivolumab plus ipilimumab treatment indicated that …
Deep Learning Reveals How Cells Pull, Buckle, And Navigate Fibrous Environments, Abinash Padhi, Arka Daw, Atharva Agashe, Medha Sawhney, Maahi M Talukder, Mehran M H Pour, Mohammad Jafari, Guy M Genin, Farid Alisafaei, Sohan Kale, Anuj Karpatne, Amrinder S Nain
Deep Learning Reveals How Cells Pull, Buckle, And Navigate Fibrous Environments, Abinash Padhi, Arka Daw, Atharva Agashe, Medha Sawhney, Maahi M Talukder, Mehran M H Pour, Mohammad Jafari, Guy M Genin, Farid Alisafaei, Sohan Kale, Anuj Karpatne, Amrinder S Nain
2020-Current year OA Pubs
Cells in tissues navigate fibrous environments fundamentally differently than they do on flat substrates, but the establishment of cell forces in physiological fibrous settings remains poorly understood. Although factors such as the stiffness of the extracellular matrix (ECM) are known to drive behaviors, including cell motility on flat nonfibrous substrates, the interplay between fiber architecture and stiffness in fibrous ECM is not known. Here, we find that in fibrous environments, the directionality of mechanical forces overrides ECM stiffness as the primary regulator of contractility in migrating cells. Using an approach combining phase microscopy with deep learning to map forces in …
Uc-1196 Verocity: A Reactive Combat Framework, Brendan Moore
Uc-1196 Verocity: A Reactive Combat Framework, Brendan Moore
C-Day Computing Showcase
Verocity is a Minecraft plugin designed for fast-paced, visceral combat, where interactivity and FUN take center stage. The complex mathematics and system design required to build this plugin push the limits of standard Minecraft development, providing a reactive framework for advanced combat interactions. New Actions and Combat Features: Enhanced Basic Attacks – Smooth, responsive, and satisfying to chain together. Throwable Items – Every item can be thrown. Swords lodge into enemies on impact, ready to be recovered. Dashing – Lunge to swords stuck in the ground or at enemies to pull them out while tactically repositioning. Umbral Blade – Command …
Gc-1162 Present Panic Game, Adetunji Adegeye, Kendrick Bryant, Catherine Ayeronwi
Gc-1162 Present Panic Game, Adetunji Adegeye, Kendrick Bryant, Catherine Ayeronwi
C-Day Computing Showcase
Present Panic is a festive top-down 2D arcade game where players control an elf inside Santa’s workshop and must collect presents while avoiding Christmas-themed enemies. During Sprint 2 in our SWE class, our team transitioned from a functional prototype to a fully developed Beta, expanding assets, implementing UI systems, building levels, and integrating polished game mechanics following the MDA framework. We developed new artwork, sound effects, animations, and user interface elements including a main menu, HUD, pause menu, and scene transitions. A survey and both manual and automated testing were prepared to gather user feedback. This Beta version forms the …