Digital Commons Network^™

Trace Level Identifications Of N-Ethylnicotinamide In Racing Horses Associated With A Vitamin B3 Supplement: Case Reports And Analysis, Clara Fenger, Kimberly Brewer, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Nikethamide, N,N-diethyl-3-pyridinecarboxamide (Coramine®) is a central nervous system stimulant at one time used therapeutically in human medicine but no longer marketed in the US. Nikethamide is classified a Drug Class 1, Penalty Class A substance by the Association of Racing Commissioners International (ARCI) and as a Horseracing Integrity and Safety Authority (HISA) SO or banned Stimulant that lacks FDA approval. Identifications of Nikethamide or its metabolite N-Ethylnicotinamide in racing samples can result in significant penalties in horse racing. Nikethamide is rapidly metabolized to N-Ethylnicotinamide, which remains detectable in plasma and urine leading to its use as a regulatory “marker” of …

What Shapes Environmental Identity: Insights From Highly Environmentally Literate Students, Marušić-Jablanović Milica, Zorica Stanišić, Jelena Stanišić, Dragana Gundogan, Tom Marcinkowski

Mathematics and System Engineering Faculty Publications

The paper aimed to describe features of the environmental identity of primary school students (age 13-14) in Serbia, as well as the experiences they find most influential in shaping their environmental identity. Specifically, students from the two best-performing classes (N=34), based on their scores on environmental literacy assessment responded to an open-ended questionnaire regarding their relationship with nature and the most important experiences shaping this relationship, in both private and school contexts. The students offered evidence of features of their environmental identity in terms of: environmental affect-sensitivity, environmental concern, moral reasoning, as well as pro-environmental behavior as its correlate. Both …

Combination Of Hsp90 Inhibitors And Hsp70 Inducers Prevent Hydrochloric Acid-Induced Pulmonary Fibrosis In Rabbits, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Dan E. Austin Jr., Len E. Murray, John D. Catravas

Bioelectrics Publications

Combined therapies with Heat Shock Protein 90 (HSP90) inhibitors and Heat Shock Protein 70 (HSP70) inducers are gaining significant interest in cancer and cardiovascular research. Here, we tested the hypothesis that HSP90 inhibitors and HSP70 inducers, together, can block the development of pulmonary fibrosis. We exposed New Zealand White Rabbits to hydrochloric acid (HCl, 0.1 N, 1.5 mL/kg), one of the top five chemicals most commonly involved in accidental exposures and inhalation injuries worldwide, and treated animals with either the orally available HSP90 inhibitor TAS-116 (1.7 mg/kg 5x/week) or TAS-116 combined with the HSP70 inducer, geranylgeranyl acetone (GGA, 50 mg/kg, …

Potentiation Of Gelonin Cytotoxicity By Pulsed Electric Fields, Olga N. Pakhomova, Eleni Zivla, Giedre Silkuniene, Mantas Silkunas, Andrei G. Pakhomov

Bioelectrics Publications

Gelonin is a ribosome-inactivating protein with extreme intracellular toxicity but poor permeation into cells. Targeted disruption of cell membranes to facilitate gelonin entry is explored for cancer and tissue ablation. We demonstrate a hundreds- to thousands-fold enhancement of gelonin cytotoxicity by pulsed electric fields in the T24, U-87, and CT26 cell lines. The effective gelonin concentration to kill 50% of cells (EC₅₀) after electroporation ranged from <1 nM to about 100 nM. For intact cells, the EC₅₀ was unattainable even at the highest gelonin concentration of 1000 nM, which reduced cell survival by only 5–15%. For isoeffective electroporation treatments using 300 ns, 9 µs, and 100 µs pulses, longer pulses were more efficient at lowering gelonin EC₅₀. Increasing the electric field strength of 8, 100 µs pulses from 0.65 to 1.25 kV/cm reduced gelonin EC₅₀ from 128 nM to 0.72 nM. Conversely, the presence of 100 nM gelonin enabled a more than 20-fold reduction in the number of pulses required for equivalent cell killing. Pulsed electric field-mediated delivery of gelonin shows promise for hyperplasia ablation at concentrations sufficiently low to minimize or avoid systemic toxicity.

The Ptp4a3 Inhibitor Kvx-053 Reduces Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Virulence, Inflammation, And Development Of Acute Lung Injury In K18-Hace2 Mice, Ruben M. L. Colunga-Biancatelli, Pavel A. Solopov, Caitlin M. Woodson, Irving Coy Allen, Ivan Akhrymuk, Maryna Akhrymuk, Brittany N. Heath, Hannah M. Ivester, Tierney Day, Dan E. Austin, Kylene Kehn-Hall, John S. Lazo, Elizabeth R. Sharlow, John D. Catravas

Bioelectrics Publications

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global health crisis, marked by high transmissibility and virulence. Despite widespread vaccination efforts, effective treatments for COVID-19, particularly for severe cases leading to Acute Respiratory Distress Syndrome (ARDS), remain limited. This study investigates the efficacy of KVX-053, a protein tyrosine phosphatase type IVA (PTP4A3) small molecule inhibitor, in modulating SARS-CoV-2-induced inflammation and lung injury using in vitro cell models and in vivo K18-hACE2 transgenic mice. KVX-053 reduced in vitro pro-inflammatory cytokine expression, including TNFα, CXCL10, and CXCL11, without impacting viral replication or cell viability. K18-hACE2 mice treated with KVX-053 demonstrated …

Place-Based Learning Practices: A Diptych Case Study Of Human And More-Than-Human Relationality At The Tribal And Western Academic Institutional Interface, Karley M. Rojas-Vienneau

Cal Poly Humboldt theses and projects

The ‘Place-Based Learning Practices Project’ is a graduate project under the Native American Studies Department Rou Dalagurr Food Sovereignty Lab and Traditional Ecological Knowledges Institute (FSL). Making contributions at the intersection of Western academia and Indigenous science, it imagines and realizes content, policies, and protocols surrounding two case studies and the larger cal poly humboldt (cph) institution which respect, honor, and uplift Indigenous sovereignty and resurgence in partnership with the Blue Lake Rancheria Tribe and the greater regional tribal community. Encompassing two projects internal and external to the institution, I aim to address the construction of controlled and protective environments …

Jaguar (Panthera Onca) Population Status And Conservation Needs In Panama Revealed Using Spatial Density And Occupancy Models., Rebeca E. Becdach

Cal Poly Humboldt theses and projects

Jaguars (Panthera onca) are key predators and the largest felid in the Americas. The species is listed as near threatened globally due to habitat loss, fragmentation, and human persecution. Their population decline can negatively affect the structure and functioning of the ecosystems they inhabit. Conservation efforts for jaguars and their habitat require understanding jaguar populations and how they are impacted by human presence across their range. This information is lacking in Panama, a critical portion of the Jaguar range. Panama forms a narrow land bridge connecting Central and South America, integral to wildlife movement, including jaguars, across both …

Anabolic Properties Of The Progestin Altrenogest And Its Regulation As An Environmental Substance In Horse Racing – Review And Analysis, Andreas F. Lehner, Levent Dirikolu, Sarah Jacob, Kimberly Brewer, Abelardo Morales Briceñoe, Robert Holland, George Maylin, Clara Fenger, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Altrenogest is a progestogen substance used in equine medicine for the synchronization of ovulation during the spring breeding season and the control of estrus in mares. It accomplishes its actions by down-regulation of endometrial progesterone receptors and repression of estrogen receptor transcriptional activation. However, various groups have also measured androgen receptor binding activity for altrenogest in vitro; these findings combined with androgenic and anabolic properties roughly 1/20 in potency of testosterone and its structural similarity to the anabolic steroid trenbolone have created concerns among racing authorities of altrenogest’s potential abilities to alter the outcome of equine athletic performance, even though …

State Constitutional Development And The Criminal Procedure Revolution, Quinn Yeargain

Georgia Law Review

Questions about which rights, liberties, and guarantees are included in the U.S. Constitution’s protections, and how they are protected, have long produced animated debate among scholars, judges, and advocates. Yet, while today’s debates may seem familiar, they take place at a perilous time in our country’s trajectory. We are six decades removed from the Warren Court’s criminal procedure revolution, and just a few years into the Roberts Court’s full-throated embrace of originalist jurisprudence. Whether many of the protections we have come to know and recognize from the Warren Court—the exclusionary rule, Miranda warnings, and Gideon’s mandate—are subjected to re-evaluation …

Csbs Statements, V26, 2025, University Of Northern Iowa. College Of Social And Behavioral Sciences.

CSBS Statements

Contents:

From the Dean --- 3
Shaping Tomorrow --- 4
Helping Students Cross the Finish Line --- 10
Beyond the Uniform --- 12
Finding the Right Fit --- 14
From Patient to Colleague --- 16
Diplomacy in Action --- 18
College News --- 20
Panther Spotlights --- 24
Annual Giving --- 26
Class Notes --- 39

Loss Of Lgl1 Increases Expression Of C-Jun And Dcx In The Svz And Rms Of The Mouse Brain, Madison Leigh Gutierrez

Cal Poly Humboldt theses and projects

Glioblastoma (GBM), the most aggressive and treatment-resistant subtype of glioma, accounts for the majority of brain tumor–related mortality. A defining feature of GBM is its ability to invade healthy brain tissue through extensive cell migration, which severely limits the effectiveness of surgical and pharmacological treatments. Increasing evidence suggests that GBM cells activate gene programs known to drive normal neural stem and progenitor cell (NSPC) migration; however, the precise molecular mechanisms shared between NSPCs and GBM cells remain poorly understood. Lethal (2) giant larvae 1 (Lgl1), a conserved cortical cytoskeletal protein, has emerged as a key regulator of polarity and migration. …

Human Perception Of Ai Capabilities At Classifying Perturbed Roadway Signs, Katherine R. Garcia, Jing Chen, Yanru Xiao, Scott Mishler, Cong Wang, Bin Hu

Psychology Faculty Publications

Artificial Intelligence (AI) is crucial to numerous functions required for driving automation systems, including the computer vision techniques used to detect the roadway environment and make real-time decisions. However, the images used as inputs to the AI system may be maliciously perturbed, or manipulated, causing the AI system to make an incorrect classification. In this study, we examined humans’ perception of the AI’s computer vision capability of classifying various road sign images, including the original images, images with two different types of malicious attacks, and images that are scrambled randomly at the pixel level. Our results showed that participants rated …

Full Issue

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

No abstract provided.

Second Shift, Eve, Nick Fife

Inscape

Nick Fife is a Deaf Studies major at UVU. They feel too much too often, so they sometimes dance it out or try to put it all on paper. Nick has a particular fondness for science fiction and calico and gray tabby cats (though a bowl of Thai curry is always welcome).

Full Issue, Cinthya Ammerman Muñoz, Paul Michael L. Atienza

Humboldt Journal of Social Relations

Full issue of Humboldt Journal of Social Relations Volume 47, Place-Based Digital Inquiry

Cint Summer Lecture Series: Investigational Devices, Abby Keeley

Human Research Protection Program (HRPP) Education

No abstract provided.

The Failures Of The Biologics Price Competition And Innovation Act, Nick Corwin

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

2025-2035 Piscataqua Region Comprehensive Conservation And Management Plan, Piscataqua Region Estuaries Partnership (Prep)

PREP Reports & Publications

No abstract provided.

Bio-Inspired Sutures: Localizing Damage By Isolating Strain Energy, Diana A. Chen, Melissa M. Gibbons

School of Engineering: Faculty Scholarship

This study draws upon bio-inspiration from anatomical sutures found in hard structures, such as turtle shells, to explore if impact energy can be dissipated through geometric parameterization rather than relying on energy-absorbing materials. While previous finite element analysis studies identified optimal dovetail suture geometries for maximizing the global stiffness and toughness of archway structures, this paper explores how different suture geometries might optimize localization effects through segmentation to isolate damage caused by the propagation of strain energy. We compare the global toughness of each suture geometry to its scaling factor, defined as the ratio of strain energy in the center …

Annual Report Of The Officers Of The Town Of Campton, New Hampshire For The Fiscal Year Ending December 31, 2024, Campton Town Representatives

Campton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Justice Requires The Freedom To Play, Heavenly Possum

Seattle Journal for Social Justice

No abstract provided.

Pd Supporting Cs And Math Integration: Implications Of Teacher Interest And Confidence For Workshop Design, K. Ann Renninger, Ruth C. Elias , '20, Mariko J. Kamiya , '19, Jennifer N. Paige , '22, Raymond A. Youngblood , '21

Educational Studies Faculty Works

Background and Context: Integrating computer science (CS) and math in classrooms is an increasingly recognized way for schools to address national CS mandates. There is a need to understand how professional development (PD) can support teachers to integrate. Objective: We examined math teachers’ interest, and confidence, in math, CS, and student learning, in relation to their participation in professional development (PD) designed to support them to integrate CS with math in their classrooms. Method: We used mixed-methods to study participants in entry-level hybrid PD, and a sub-group of those participants who took the workshop a second time. Findings: Results showed …

2024 Annual Report Town Of Springfield, New Hampshire, Springfield Town Representatives

Springfield, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Budget Oversight Policy 1st Quarter Budget Review Fy 2025-26, Csusb Budget Office

University Budget Office records

No abstract provided.

The Sustainability Of The Outdoor Recreation Industry: Studied Through Mountaineering In Teton County, Wy, Samantha Olstein

Student Research and Publications

No abstract provided.

Listening To Cursive: The Roles Of Regional Identity And Folk Beliefs In Perceptual Cue-Weighting, Stella Takvoryan

Theses and Dissertations--Linguistics

Listeners use knowledge acquired from experiences to weight phonetic-level cues to phonological contrasts. Phonetic knowledge is imbued with expectations about the contexts in which cues covary, speakers of a variety, and identity categories or constructs, so it can be challenging to distinguish expectations about variation from expectations about speakers. This study aims to explore the extent that expectations about iconic vowel quality variation in Southern American Englishes can drive cue-weighting. Listeners categorized stimuli with vowel qualities synthesized from an [ɛ]-[eɪ] continuum from a Southern and a non-Southern talker, with duration manipulated in tandem. Half of the participants saw a label …

The Effect Of Fructose Metabolism On Hepatic De Novo Lipogenesis And Adipose Tissue Insulin Resistance, Taghreed Ibrahim Fadhul

Theses and Dissertations--Nutritional Sciences

There is a worldwide epidemic of obesity and metabolic dysfunction. The root cause of obesity is driven by a positive energy balance, which is a consequence of increased caloric intake and decreased energy expenditure. Energy intake is the more dominant force, as increasing energy expenditure is a time-consuming and labor-intensive process. The caloric surplus can be mainly accounted for by increased consumption of high-fat and high-sugar diets. While the risks associated with fat consumption are well-documented, the impact of sugar intake is less understood.

Fructose is a simple sugar widely consumed in modern diets. Its intake has been associated with …

Spermidine And Polyamine Blockade As Key Mediators Of Intestinal Epithelial Cell Functions, Madison Lynn Flory

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Frequently, alterations in the composition of the gut microbiota and its metabolites are linked with intestinal diseases, including inflammatory bowel disease and colorectal cancer. However, the direct connections between alterations in the microbiome and disease states often remain elusive. Prior research has identified increases in both polyamines, which are a class of microbial metabolite, and in the abundance of bacteria that can produce polyamines, in a murine colorectal cancer model. Understanding the significance of the interaction between these microbial metabolites and intestinal epithelial cells (IECs) will provide new and expanded evidence of the importance of the gut microbiome in colorectal …

Common Law Executive Privilege(S), Jonathan Shaub

Law Faculty Scholarly Articles

There are few Supreme Court cases that enjoy as much widespread support as the unanimous decision in United States v. Nixon. The recent pitched battles between Congress and the executive branch have made apparent the vast disagreement between the two branches over access to information. But that disagreement does not extend to Nixon, the unquestioned jurisprudential foundation for the doctrine of executive privilege. Closer inspection shows, however, that this foundation is not a stable one, but one constructed from unnecessary, ill-considered dicta.

As this Article demonstrates, Nixon conflated the constitutional question about one branch’s power vis-à-vis another branch with an …

Visual Legal Rhetoric In The Age Of Generative Ai And Deepfakes: Renaissance Or Dark Ages?, Michael D. Murray

Law Faculty Scholarly Articles

The paradoxical development of visual generative AI tools, such as OpenAI’s DALL-E 3, Midjourney, and Stable Diffusion, simultaneously signals a renaissance and a potential dark age in visual rhetoric and communication. On the one hand, these tools democratize the creation of visual content, empowering attorneys and others to become artists and illustrators of their legal communications without needing to learn how to draw. These AI systems can simplify complex legal concepts, bridge language barriers, and enhance advocacy. But on the other hand, the proliferation of deepfakes presents significant challenges for visual rhetoric. Deepfakes can quickly and easily create realistic but …